@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Z_NR2B3_RXRGB: (2016-04-07 )
MDTHDTYLHLHSSPLNSSPSQPPVMSSMVGHPSVISSSRPLPSPMSTLGSSMNGLPSPYSVITPSLSSPSISLPSTPSMGFNTLNSPQMNSLSMNGNEDIKPPPGLAPLGNMSSYQCTSPGSLSKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDIKECLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKEKSDTEVETTSRFNEDMPVDKILDAELSVEPKTETYTESSPSNSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSITVKDGILLGTGLHVHRSSAHSAGVGSIFNRVLTELVSKMKDMQMDKTELGCLRAIVLFNPDAKGLSNSLEVEALREKVYASLETYTKQKYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQIT
Atome Classification :
(73 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240....----...250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDTH
D
T
Y
L
H
L
HSSPLNSSPSQPP
V
M
S
S
MVGHPSVISSSRPLPS
P
M
S
T
L
G
S
SMNGLPSPY
S
V
ITPSLSSPSISLPSTPSMGFNTLNSPQM
N
S
LSMNGNEDIKPPPGLAPLGNMS
S
Y
QCTSPG
S
L
S
K
H
I
C
A
ICGDRSSGKHY
G
V
Y
SCE
G
C
K
G
F
F
K
R
T
I
R
K
DL
T
Y
T
C
R
D
I
K
E
C
L
I
D
K
R
QR
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
MG
M
K
R
E
A
V
Q
E
E
R
Q
RGKEKSDTEVETTSRFNEDMP
V
D
K
ILDAELSVEPKTETYTESS----PSNSTND
P
V
T
N
I
C
H
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
RIPHFSDLPLDD
Q
V
I
L
L
RAGWN
E
L
L
I
A
SFSH
R
S
I
T
V
KD
G
I
L
L
G
T
G
L
H
V
HRSSAHSA
G
V
G
S
I
F
N
R
V
L
T
E
L
V
S
K
M
K
D
MQM
D
K
T
E
L
G
C
L
R
A
I
V
L
FNPDAKGLSNS
L
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
T
Y
T
KQKYPDQ
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
IGDT
P
I
D
T
F
L
M
E
M
LEAPHQIT
2
PsiBlast_PDB
90.94
74%
-118
- C3 -
3E00
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
--------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
----------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
1
PsiBlast_PDB
89.86
74%
-118
- C3 -
3DZU
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
--------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
----------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
61
PsiBlast_CBE
85.34
87%
-108
- C3 -
1XVP
1
RXRA_HUMAN
C:
[1-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
Q
M
T
10
PsiBlast_PDB
85.02
87%
-118
- C3 -
1MZN
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
---------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
31
PsiBlast_CBE
84.78
87%
-118
- C3 -
1MZN
1
RXRA_HUMAN
E:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
---------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
73
PsiBlast_CBE
84.55
87%
-122
- C3 -
4PP3
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
74
PsiBlast_CBE
84.37
87%
-123
- C3 -
4POJ
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
58
PsiBlast_CBE
84.37
87%
-112
- C3 -
1FM9
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
46
PsiBlast_CBE
84.34
88%
-122
- C3 -
1XDK
1
RXRA_MOUSE
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
-----------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
13
PsiBlast_PDB
84.33
87%
-123
- C3 -
2P1V
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
49
PsiBlast_CBE
84.21
87%
-126
- C3 -
3OZJ
1
RXRA_HUMAN
C:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
55
PsiBlast_CBE
84.14
87%
-112
- C3 -
1K74
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
32
PsiBlast_CBE
84.12
87%
-122
- C3 -
1MZN
1
RXRA_HUMAN
C:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
16
PsiBlast_PDB
84.07
87%
-120
- C3 -
2ZY0
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
79
PsiBlast_CBE
83.98
87%
-124
- C3 -
4K4J
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
30
PsiBlast_CBE
83.86
87%
-121
- C3 -
1MZN
1
RXRA_HUMAN
G:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
63
PsiBlast_CBE
83.85
87%
-106
- C3 -
1XV9
1
RXRA_HUMAN
C:
[1-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
76
PsiBlast_CBE
83.79
87%
-121
- C3 -
4M8H
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
29
PsiBlast_CBE
83.79
87%
-119
- C3 -
2ZY0
1
RXRA_HUMAN
C:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
22
PsiBlast_CBE
83.74
87%
-127
- C3 -
3R5M
1
RXRA_HUMAN
C:
[6-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
14
PsiBlast_PDB
83.69
87%
-124
- C3 -
3FUG
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
8
PsiBlast_PDB
83.65
87%
-122
- C3 -
1MV9
1
RXRA_HUMAN
A:
[7-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
Q
--
84
PsiBlast_CBE
83.60
82%
-129
- C3 -
1UHL
1
A:
[1-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
P
V
D
R
I
L
E
A
E
L
A
V
E
Q
----------------
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
12
PsiBlast_PDB
83.58
87%
-127
- C3 -
2P1U
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
65
PsiBlast_CBE
83.56
87%
-120
- C3 -
4RME
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
50
PsiBlast_CBE
83.49
87%
-121
- C3 -
3OZJ
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
9
PsiBlast_PDB
83.47
87%
-122
- C3 -
1MVC
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
41
PsiBlast_CBE
83.46
87%
-125
- C3 -
3E94
1
RXRA_HUMAN
A:
[11-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
5
PsiBlast_PDB
83.46
87%
-123
- C3 -
4OC7
1
RXRA_HUMAN
A:
[21-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
45
PsiBlast_CBE
83.39
88%
-123
- C3 -
1XDK
1
RXRA_MOUSE
E:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
-----------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
75
PsiBlast_CBE
83.35
87%
-125
- C3 -
4POH
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
112
HHSearch
83.31
88%
-126
- C3 -
2P1T
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
72
PsiBlast_CBE
83.27
87%
-123
- C3 -
4PP5
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
23
PsiBlast_CBE
83.19
87%
-119
- C3 -
3R5M
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
64
PsiBlast_CBE
83.16
87%
-106
- C3 -
1XV9
1
RXRA_HUMAN
A:
[1-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
11
PsiBlast_PDB
83.14
87%
-126
- C3 -
2P1T
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
59
PsiBlast_CBE
83.13
87%
-113
- C3 -
1FM6
1
RXRA_HUMAN
U:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
82
PsiBlast_CBE
83.09
87%
-128
- C3 -
3PCU
1
RXRA_HUMAN
A:
[1-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
60
PsiBlast_CBE
83.09
87%
-111
- C3 -
1FM6
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
80
PsiBlast_CBE
83.08
87%
-121
- C3 -
3OAP
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
77
PsiBlast_CBE
83.05
87%
-125
- C3 -
4M8E
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
78
PsiBlast_CBE
83.03
87%
-120
- C3 -
4K6I
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
71
PsiBlast_CBE
83.03
87%
-124
- C3 -
4RFW
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
62
PsiBlast_CBE
82.95
87%
-108
- C3 -
1XVP
1
RXRA_HUMAN
A:
[1-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
70
PsiBlast_CBE
82.92
87%
-119
- C3 -
4RMC
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
42
PsiBlast_CBE
82.82
87%
-122
- C3 -
3UVV
1
RXRA_HUMAN
B:
[7-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
---------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
40
PsiBlast_CBE
82.76
87%
-126
- C3 -
3KWY
1
RXRA_HUMAN
A:
[11-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
--
I
D
T
F
L
M
E
M
L
E
A
P
----
15
PsiBlast_PDB
82.72
87%
-124
- C3 -
2ZXZ
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
44
PsiBlast_CBE
82.30
87%
-122
- C3 -
1RDT
1
RXRA_HUMAN
A:
[8-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
81
PsiBlast_CBE
81.11
87%
-120
- C3 -
1DKF
1
RXRA_MOUSE
A:
[3-233]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
-----------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
A
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
47
PsiBlast_CBE
80.40
87%
-114
- C3 -
1FBY
1
RXRA_HUMAN
B:
[6-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
48
PsiBlast_CBE
80.10
87%
-111
- C3 -
1FBY
1
RXRA_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
85
PsiBlast_CBE
79.96
80%
-110
- C3 -
1XIU
1
RXR_BIOGL
B:
[3-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
D
M
P
V
E
Q
I
L
E
A
E
L
A
V
D
P
K
I
D
T
Y
I
D
A
Q
---------
K
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
T
E
L
P
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
G
F
S
H
R
S
I
M
A
K
D
G
I
L
L
A
T
G
L
H
V
H
R
S
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
V
V
L
F
N
P
D
A
K
G
L
T
A
V
Q
E
V
E
Q
L
R
E
K
V
Y
A
S
L
E
E
Y
T
K
S
R
Y
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
Q
P
I
D
T
F
L
M
E
M
L
E
N
P
----
56
PsiBlast_CBE
79.55
87%
-116
- C3 -
1G5Y
1
RXRA_HUMAN
C:
[7-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
83
PsiBlast_CBE
79.14
87%
-107
- C3 -
3H0A
1
A:
[1-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
89
PsiBlast_CBE
79.07
83%
-128
- C3 -
1H9U
1
RXRB_HUMAN
C:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
91
PsiBlast_CBE
78.92
83%
-130
- C3 -
1H9U
1
RXRB_HUMAN
A:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
43
PsiBlast_CBE
78.56
87%
-107
- C3 -
3FC6
1
RXRA_HUMAN
C:
[7-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
-------------
D
T
F
L
M
E
M
L
E
A
-----
38
PsiBlast_CBE
78.47
87%
-124
- C3 -
4N5G
1
?
C:
[13-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
--------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
88
PsiBlast_CBE
78.41
83%
-126
- C3 -
1H9U
1
D:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
57
PsiBlast_CBE
78.33
87%
-108
- C3 -
1G5Y
1
RXRA_HUMAN
B:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
MGLN
P
S
-
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---
7
PsiBlast_PDB
77.74
87%
-109
- C3 -
3A9E
1
RXRA_MOUSE
A:
[3-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
K
---------------
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
90
PsiBlast_CBE
77.58
83%
-127
- C3 -
1H9U
1
RXRB_HUMAN
B:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
86
PsiBlast_CBE
77.33
80%
-114
- C3 -
1XIU
1
RXR_BIOGL
A:
[4-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
M
P
V
E
Q
I
L
E
A
E
L
A
V
D
P
K
I
D
T
Y
I
D
A
Q
---------
K
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
T
E
L
P
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
G
F
S
H
R
S
I
M
A
K
D
G
I
L
L
A
T
G
L
H
V
H
R
S
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
V
V
L
F
N
P
D
A
K
G
L
T
A
V
Q
E
V
E
Q
L
R
E
K
V
Y
A
S
L
E
E
Y
T
K
S
R
Y
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
Q
P
I
D
T
F
L
M
E
M
L
E
------
25
PsiBlast_CBE
75.71
87%
-115
- C3 -
3R2A
1
RXRA_HUMAN
C:
[6-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
---------
20
PsiBlast_PDB
75.22
87%
-109
- C3 -
3R2A
1
RXRA_HUMAN
A:
[4-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
---------
35
PsiBlast_CBE
75.14
87%
-128
- C3 -
4N8R
1
?
B:
[43-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
34
PsiBlast_CBE
74.97
87%
-129
- C3 -
4N8R
1
?
C:
[44-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
33
PsiBlast_CBE
73.85
87%
-128
- C3 -
4N8R
1
?
D:
[45-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---
37
PsiBlast_CBE
73.21
87%
-127
- C3 -
4N5G
1
?
D:
[45-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
39
PsiBlast_CBE
73.15
87%
-127
- C3 -
4N5G
1
RXRA_HUMAN
A:
[45-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
92
PsiBlast_CBE
73.06
73%
-132
- C3 -
4OZT
1
?
U:
[1-193]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
A
N
I
C
Q
A
T
N
S
Q
L
Y
Q
L
V
E
W
A
K
H
I
P
H
F
S
S
L
P
I
E
D
Q
V
L
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
V
E
V
R
D
G
I
V
L
G
A
G
I
T
V
H
R
N
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
N
M
D
R
T
E
L
G
S
L
R
S
I
I
L
F
N
P
E
V
R
G
L
K
S
G
Q
E
V
E
L
L
R
E
K
V
Y
A
A
L
E
E
Y
T
R
V
T
R
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
I
P
I
D
T
F
L
M
D
M
L
G
S
-----
36
PsiBlast_CBE
72.89
87%
-124
- C3 -
4N8R
1
RXRA_HUMAN
A:
[45-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---