@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Z_NR3A1_ESR1: (2016-04-07 )
MYPKEEHSAGGISSSVNYLDGAYEYPNPTQTFGTSSPAEPASVGYYPAPPDPHEEHLQTLGGGSSSPLMFAPSSPQLSPYLSHHGGHHTTPHQVSYYLDSSSSTVYRSSVVSSQQAAVGLCEELCSATDRQELYTGSRAAGGFDSGKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQACRLRKCYEVGMMKGGIRKDRGGRSVRRERRRSSNEDRDKSSSDQCSRAGVRTTGPQDKRKKRSGGVVSTLCMSPDQVLLLLLGAEPPAVCSRQKHSRPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPGKLIFAQDLILDRSEGECVEGMAEIFDMLLATVARFRSLKLKLEEFVCLKAIILINSGAFSFCSSPVEPLMDNFMVQCMLDNITDALIYCISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQRFQSSGKVQRVWSQSEKNPPSTPTTSSSSSNNSPRGGAAAIQSNGACHSHSPDP
Atome Classification :
(139 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYPKEEHSAGGISSSVNYLDGAYEYPNPTQTFGTSSPAEPASVGYYPAPPDP
H
E
E
H
L
Q
T
LGGGSSS
P
L
M
FAPSSPQL
S
P
Y
L
S
HHGGHHTTP
H
Q
V
S
Y
Y
LDSSSS
T
V
Y
R
S
S
VVS
S
Q
Q
A
A
V
G
L
C
E
E
L
C
SAT
D
R
Q
E
LYTGSRAAGGFDSGKE
T
R
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
VCPATN
Q
C
TIDRNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
MMKGGIRKDRGG
R
S
V
R
R
E
R
RRSSNEDRDKSSS
D
Q
C
S
RAGVRTTG
P
Q
D
K
R
K
KRSGG
V
V
S
T
LCMSPD
Q
V
L
L
L
L
LGAE
P
P
A
V
C
SRQKHSRP
Y
T
E
I
T
M
M
S
L
L
T
N
M
A
D
K
E
L
V
H
M
I
A
W
A
K
KVPGFQDL
S
L
H
D
Q
V
Q
L
L
E
S
S
W
L
E
V
L
M
I
G
L
I
W
R
S
IHSPG
K
L
I
F
A
Q
D
LILDRSE
G
E
C
V
E
G
M
A
E
I
F
D
M
L
L
A
T
V
A
R
F
R
S
L
K
L
K
L
E
E
F
V
C
L
K
A
I
I
L
INSG
A
F
S
F
C
SS
P
V
E
P
L
M
D
N
F
M
V
Q
C
M
L
D
N
I
T
D
A
L
I
Y
C
ISKSG
A
S
L
Q
L
Q
S
R
R
Q
A
Q
L
L
L
L
L
S
H
I
R
H
M
S
NK
G
M
E
H
L
Y
R
M
K
CKNRV
P
L
Y
D
L
L
L
E
M
L
D
A
Q
R
F
QSSG
K
V
Q
R
V
W
S
QSEKNPPSTPTTSSSSSNNSPRGG
A
A
A
IQSNGACHSHSPDP
39
PsiBlast_CBE
90.95
63%
-153
- C3 -
1XPC
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
5
PsiBlast_PDB
90.93
62%
-135
- C3 -
2YJA
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
133
PsiBlast_CBE
90.80
63%
-143
- C3 -
4PP6
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
53
PsiBlast_CBE
90.75
61%
-138
- C3 -
2QR9
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
14
PsiBlast_PDB
90.74
61%
-139
- C3 -
2QA8
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
51
PsiBlast_CBE
90.72
61%
-137
- C3 -
2QSE
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
18
PsiBlast_PDB
90.66
63%
-145
- C3 -
1XP1
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
118
PsiBlast_CBE
90.60
63%
-146
- C3 -
4IVW
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
57
PsiBlast_CBE
90.56
61%
-138
- C3 -
2QGW
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
65
PsiBlast_CBE
90.53
61%
-134
- C3 -
2Q6J
1
B:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
128
PsiBlast_CBE
90.51
63%
-142
- C3 -
4PPS
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
19
PsiBlast_PDB
90.51
63%
-148
- C3 -
1XP6
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
116
PsiBlast_CBE
90.49
63%
-143
- C3 -
4IVY
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
56
PsiBlast_CBE
90.49
61%
-142
- C3 -
2QH6
1
ESR1_HUMAN
A:
[8-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
38
PsiBlast_CBE
90.49
63%
-146
- C3 -
1YIM
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
108
PsiBlast_CBE
90.46
63%
-141
- C3 -
4IWF
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
216
HHSearch
90.42
63%
-154
- C3 -
1XPC
1
A:
[6-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
42
PsiBlast_CBE
90.38
63%
-137
- C3 -
1QKU
1
ESR1_HUMAN
A:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
62
PsiBlast_CBE
90.36
61%
-139
- C3 -
2QAB
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
121
PsiBlast_CBE
90.32
63%
-144
- C3 -
4IV2
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
141
PsiBlast_CBE
90.30
61%
-149
- C3 -
2QXS
1
ESR1_HUMAN
A:
[10-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-
R
P
F
S
-
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
102
PsiBlast_CBE
90.28
63%
-147
- C3 -
4DMA
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
139
PsiBlast_CBE
90.27
63%
-149
- C3 -
1PCG
1
ESR1_HUMAN
A:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-----------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
64
PsiBlast_CBE
90.25
61%
-135
- C3 -
2QA6
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
103
PsiBlast_CBE
90.23
63%
-138
- C3 -
4DMA
1
ESR1_HUMAN
A:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
131
PsiBlast_CBE
90.22
63%
-148
- C3 -
4PPP
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
105
PsiBlast_CBE
90.20
63%
-142
- C3 -
1X7E
1
B:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
109
PsiBlast_CBE
90.18
63%
-142
- C3 -
4IWC
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
20
PsiBlast_PDB
90.15
63%
-147
- C3 -
1XP9
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
61
PsiBlast_CBE
90.14
61%
-138
- C3 -
2QAB
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
17
PsiBlast_PDB
90.13
63%
-150
- C3 -
1SJ0
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
40
PsiBlast_CBE
90.08
63%
-137
- C3 -
1QKU
1
C:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
48
PsiBlast_CBE
90.03
63%
-146
- C3 -
2IOG
1
A:
[2-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
143
PsiBlast_CBE
90.01
61%
-141
- C3 -
3L03
1
B:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
---
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
69
PsiBlast_CBE
90.02
63%
-143
- C3 -
1GWR
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
50
PsiBlast_CBE
90.01
61%
-140
- C3 -
2QXM
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
60
PsiBlast_CBE
89.99
61%
-139
- C3 -
2QGT
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
52
PsiBlast_CBE
89.98
61%
-144
- C3 -
2QSE
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
---
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
122
PsiBlast_CBE
89.94
63%
-146
- C3 -
4IV2
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
41
PsiBlast_CBE
89.94
63%
-140
- C3 -
1QKU
1
ESR1_HUMAN
B:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
117
PsiBlast_CBE
89.91
63%
-141
- C3 -
4IVW
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
--
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
58
PsiBlast_CBE
89.91
61%
-138
- C3 -
2QGW
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
106
PsiBlast_CBE
89.89
63%
-141
- C3 -
1X7E
1
ESR1_HUMAN
A:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
144
PsiBlast_CBE
89.87
61%
-139
- C3 -
3L03
2
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
125
PsiBlast_CBE
89.82
63%
-140
- C3 -
4IU7
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
67
PsiBlast_CBE
89.81
61%
-138
- C3 -
2P15
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
44
PsiBlast_CBE
89.81
63%
-141
- C3 -
1GWQ
1
ESR1_HUMAN
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
140
PsiBlast_CBE
89.79
61%
-151
- C3 -
2QXS
1
B:
[10-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
---------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
10
PsiBlast_PDB
89.75
61%
-133
- C3 -
3Q95
1
ESR1_HUMAN
A:
[11-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
--
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
132
PsiBlast_CBE
89.74
63%
-143
- C3 -
4PP6
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
46
PsiBlast_CBE
89.70
63%
-140
- C3 -
1G50
1
ESR1_HUMAN
B:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
129
PsiBlast_CBE
89.68
63%
-137
- C3 -
4PPS
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
-
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
142
PsiBlast_CBE
89.65
61%
-143
- C3 -
2QA8
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
138
PsiBlast_CBE
89.65
63%
-139
- C3 -
1PCG
1
B:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
9
PsiBlast_PDB
89.61
59%
-144
- C3 -
4PXM
1
ESR1_HUMAN
A:
[24-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
G
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
82
PsiBlast_CBE
89.58
62%
-150
- C3 -
2R6Y
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
91
PsiBlast_CBE
89.57
62%
-144
- C3 -
2AYR
1
A:
[5-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
63
PsiBlast_CBE
89.57
61%
-138
- C3 -
2QA6
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
49
PsiBlast_CBE
89.57
61%
-138
- C3 -
2QXM
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
84
PsiBlast_CBE
89.56
62%
-153
- C3 -
2R6W
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
74
PsiBlast_CBE
89.55
62%
-153
- C3 -
1XQC
1
ESR1_HUMAN
A:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
130
PsiBlast_CBE
89.50
63%
-142
- C3 -
4PPP
1
B:
[5-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
110
PsiBlast_CBE
89.50
63%
-141
- C3 -
4IWC
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
47
PsiBlast_CBE
89.47
63%
-135
- C3 -
1G50
1
ESR1_HUMAN
A:
[5-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
115
PsiBlast_CBE
89.46
63%
-139
- C3 -
4IVY
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
112
PsiBlast_CBE
89.45
63%
-138
- C3 -
4IW8
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
70
PsiBlast_CBE
89.42
63%
-139
- C3 -
1GWR
1
ESR1_HUMAN
A:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
77
PsiBlast_CBE
89.41
61%
-136
- C3 -
3HLV
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
59
PsiBlast_CBE
89.41
61%
-136
- C3 -
2QGT
1
B:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
37
PsiBlast_CBE
89.41
63%
-149
- C3 -
1YIN
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
13
PsiBlast_PDB
89.40
63%
-146
- C3 -
2OUZ
1
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
72
PsiBlast_CBE
89.38
62%
-149
- C3 -
1XQC
1
ESR1_HUMAN
C:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
68
PsiBlast_CBE
89.37
61%
-133
- C3 -
2P15
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
124
PsiBlast_CBE
89.32
63%
-140
- C3 -
4IU7
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
54
PsiBlast_CBE
89.33
61%
-139
- C3 -
2QR9
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
114
PsiBlast_CBE
89.32
63%
-142
- C3 -
4IW6
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
45
PsiBlast_CBE
89.32
63%
-139
- C3 -
1G50
1
C:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
100
PsiBlast_CBE
89.29
61%
-144
- C3 -
3OS8
1
D:
[10-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
43
PsiBlast_CBE
89.21
63%
-140
- C3 -
1GWQ
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
90
PsiBlast_CBE
89.20
62%
-149
- C3 -
2POG
1
ESR1_HUMAN
A:
[5-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
93
PsiBlast_CBE
89.17
61%
-143
- C3 -
3OSA
1
D:
[10-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
79
PsiBlast_CBE
89.17
62%
-142
- C3 -
4ZN9
1
?
B:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
---------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
T
S
-----------------------------------------------
120
PsiBlast_CBE
89.13
63%
-142
- C3 -
4IV4
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
----
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
4
PsiBlast_PDB
89.13
62%
-148
- C3 -
3DT3
1
ESR1_HUMAN
A:
[10-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
66
PsiBlast_CBE
89.12
61%
-134
- C3 -
2Q6J
1
ESR1_HUMAN
A:
[10-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
80
PsiBlast_CBE
89.10
62%
-149
- C3 -
4ZN9
1
?
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
T
S
-----------------------------------------------
113
PsiBlast_CBE
89.07
63%
-140
- C3 -
4IW6
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
25
PsiBlast_CBE
89.06
59%
-146
- C3 -
4PXM
1
B:
[22-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
G
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
119
PsiBlast_CBE
89.03
63%
-140
- C3 -
4IV4
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
--------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
81
PsiBlast_CBE
89.03
62%
-157
- C3 -
2R6Y
1
B:
[5-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
95
PsiBlast_CBE
89.02
61%
-139
- C3 -
3OSA
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
2
PsiBlast_PDB
88.99
61%
-148
- C3 -
3ERT
1
A:
[13-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------------
107
PsiBlast_CBE
88.98
63%
-147
- C3 -
4IWF
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
15
PsiBlast_PDB
88.96
61%
-144
- C3 -
2QZO
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
-------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
----------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
83
PsiBlast_CBE
88.94
62%
-154
- C3 -
2R6W
1
B:
[5-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
--------
P
L
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
146
PsiBlast_CBE
88.93
60%
-143
- C3 -
3OS8
1
ESR1_HUMAN
A:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
127
PsiBlast_CBE
88.91
62%
-154
- C3 -
5AK2
1
ESR1_HUMAN
A:
[22-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------------
101
PsiBlast_CBE
88.91
61%
-143
- C3 -
3OS8
1
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
88
PsiBlast_CBE
88.88
62%
-144
- C3 -
2Q70
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
----
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
55
PsiBlast_CBE
88.83
61%
-144
- C3 -
2QH6
1
B:
[9-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
76
PsiBlast_CBE
88.80
61%
-137
- C3 -
3HLV
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-----
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
145
PsiBlast_CBE
88.78
60%
-144
- C3 -
3OS8
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
134
PsiBlast_CBE
88.68
63%
-151
- C3 -
2I0J
1
D:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
6
PsiBlast_PDB
88.67
57%
-139
- C3 -
2OCF
1
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
94
PsiBlast_CBE
88.59
61%
-144
- C3 -
3OSA
1
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
111
PsiBlast_CBE
88.50
63%
-139
- C3 -
4IW8
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
73
PsiBlast_CBE
88.38
62%
-151
- C3 -
1XQC
1
ESR1_HUMAN
B:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
152
PsiBlast_CBE
88.31
60%
-151
- C3 -
2J7Y
7
A:
[9-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
-----
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
92
PsiBlast_CBE
88.31
62%
-146
- C3 -
1QKT
1
A:
[5-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
126
PsiBlast_CBE
88.27
62%
-162
- C3 -
5AK2
1
B:
[22-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----------
L
L
E
M
L
D
--------------------------------------------------------
136
PsiBlast_CBE
88.08
63%
-150
- C3 -
2I0J
1
ESR1_HUMAN
B:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
-------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
23
PsiBlast_CBE
88.02
61%
-145
- C3 -
1R5K
1
ESR1_HUMAN
B:
[13-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
153
PsiBlast_CBE
87.95
60%
-149
- C3 -
2J7X
5
A:
[9-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
---
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
3
PsiBlast_PDB
87.94
61%
-142
- C3 -
1R5K
2
ESR1_HUMAN
A:
[13-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
123
PsiBlast_CBE
87.83
63%
-143
- C3 -
4IUI
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
24
PsiBlast_CBE
87.57
62%
-136
- C3 -
1A52
1
B:
[9-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
11
PsiBlast_PDB
87.54
63%
-150
- C3 -
2IOK
1
ESR1_HUMAN
A:
[8-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-----
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
104
PsiBlast_CBE
87.50
63%
-143
- C3 -
1X7R
1
A:
[4-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
71
PsiBlast_CBE
87.46
62%
-149
- C3 -
1XQC
1
D:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
8
PsiBlast_PDB
87.33
63%
-149
- C3 -
3UUC
1
ESR1_HUMAN
A:
[7-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
---
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-------
Y
D
L
L
L
E
M
L
---------------------------------------------------------
98
PsiBlast_CBE
87.31
61%
-145
- C3 -
3OS9
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
7
PsiBlast_PDB
87.15
62%
-138
- C3 -
1A52
1
ESR1_HUMAN
A:
[10-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
99
PsiBlast_CBE
87.01
61%
-147
- C3 -
3OS9
1
ESR1_HUMAN
A:
[12-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
-
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
22
PsiBlast_CBE
86.91
61%
-148
- C3 -
1R5K
1
C:
[13-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
148
PsiBlast_CBE
86.87
62%
-149
- C3 -
2JF9
4
C:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------------
26
PsiBlast_CBE
86.68
63%
-146
- C3 -
2IOK
1
B:
[8-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-------
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
78
PsiBlast_CBE
86.25
62%
-148
- C3 -
2YAT
3
A:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
---------
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
97
PsiBlast_CBE
86.19
61%
-148
- C3 -
3OS9
2
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
150
PsiBlast_CBE
86.00
62%
-144
- C3 -
2JF9
5
ESR1_HUMAN
A:
[27-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
96
PsiBlast_CBE
85.90
61%
-155
- C3 -
3OS9
2
D:
[11-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
S
Y
D
L
L
L
E
M
L
---------------------------------------------------------
151
PsiBlast_CBE
84.86
62%
-142
- C3 -
2BJ4
1
ESR1_HUMAN
A:
[27-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
149
PsiBlast_CBE
84.86
62%
-150
- C3 -
2JF9
3
ESR1_HUMAN
B:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------------
89
PsiBlast_CBE
84.27
62%
-143
- C3 -
2POG
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
86
PsiBlast_CBE
84.26
62%
-148
- C3 -
2QE4
1
ESR1_HUMAN
A:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
147
PsiBlast_CBE
83.73
62%
-140
- C3 -
2JFA
1
ESR1_HUMAN
A:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------------
87
PsiBlast_CBE
83.74
62%
-144
- C3 -
2Q70
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
85
PsiBlast_CBE
83.73
62%
-147
- C3 -
2QE4
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
135
PsiBlast_CBE
83.17
63%
-141
- C3 -
2I0J
1
ESR1_HUMAN
C:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------
137
PsiBlast_CBE
83.07
63%
-141
- C3 -
2I0J
1
ESR1_HUMAN
A:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------------