@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0295: (2015-11-30 )
MRLEKLESQTADGNLWQDNQKAQEVLKEYSKIKNDVESFSKLESDYNDAISLMKSAIDENDEEFFSEVENELVKLEKLIKRKETDFLFTDEADNNDCFLEIHSGAGGTESNDWAEMLMRMYIRWAEIYHNFKVEVVEKLEGDSIGIKSAIIKIIGEKAYGWAKSESGIHRLVRISPFDANSKRHTSFVSIGVTPVIEDSIDIAVDEGTLKIDTYRASGAGGQHVNKTESAVRVTHIPTGVIVQCQNNRSQHQNKNEALKLLKGRLYQIKLEKKEQKMAEEYGKKCGIGWGNQIRSYVMHPYQMVKDLRTGYEVGNINSIFDGNIDCFIVNVLTNKN
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------.........10.---------------......--.20........30........40--..-.......50------.........--60---......---..70........80...----.-....90........100----....-.....110.......120....-...130.......140...---....150....--...160-----------.....---...170.......180........190.--------------------...----------------...200.......210------..--.....220......---.230----...--------------------.---------------------.------.-----.-----------------.-----------------.-------------------------240........250.......260...--...--.270.......280...--------....-290--..---......300.......310.....------..320.......330....-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------M
R
L
E
K
LESQTAD---------------GNLWQD--
N
Q
K
A
Q
E
V
L
K
E
Y
S
K
I
K
N
D
V
E
S
F
S
---
K
L
-
E
S
D
Y
N
D
A
I
-------
S
L
M
K
S
AIDE--
N
D
---
E
E
F
F
S
E
---
V
E
N
E
L
V
K
L
E
K
L
I
K
RKET----
D
-
F
L
F
TDEADNN
D
C
F
L
E
------
I
HSG-AGGTES
N
D
W
A
E
M
L
M
R
M
Y
I
R
W
A
E
-
I
Y
H
N
F
K
V
E
V
V
E
K
LEGDSI
G
---
I
K
S
A
I
I
K
I
I
GE--KAYGW------------AKSES---G
I
H
R
L
V
R
ISPFDANS-K
R
H
T
S
F
V
S
IGVT--------------------PVI----------------EDS
I
D
I
A
VDE
G
T
L
K
I
D
------
T
Y
--RASGAGGQHVNKTE---S
A
------
V
R
V
--------------------
T
---------------------H------I-----P-----------------T-----------------
G
-------------------------
V
-
I
V
Q
CQNNRSQHQ
N
K
N
E
A
L
K
L
L
KG
R
L
--
Y
Q
I
--
K
L
E
K
K
E
Q
K
M
A
E
E
Y
G
K
KC--------GIG
W
-
G
N
---
Q
I
---
R
S
Y
V
M
H
P
Y
Q
M
V
K
D
L
R
TGYEVGNI
N
------
S
IFDGNI
D
C
F
I
V
N
V
LTNKN-------------------------------------------------
6
PsiBlast_PDB
84.16
32%
-73
- C5 -
2B3T
-
RF1_ECOLI
B:
[15-345]
----------------------------------------------------------------------------------
R
H
E
E
V
Q
A
L
L
G
D
---------------
A
Q
T
I
A
D
--
Q
E
R
F
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
R
C
F
T
D
W
Q
Q
V
-----------------------------------------------------
Q
Q
L
Q
V
----
L
-
L
L
P
K
D
P
D
D
E
R
N
A
F
L
E
------
V
R
A
G
-
T
G
G
D
E
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
A
E
-
A
-
R
R
W
R
V
E
I
M
S
A
S
E
G
E
H
G
G
---
Y
K
E
I
I
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K
I
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--
G
V
Y
G
R
------------
L
K
F
E
S
---
G
G
H
R
V
Q
R
V
P
A
T
E
S
Q
G
-
R
I
H
T
S
A
C
T
V
A
V
M
--------------------
P
E
L
----------------
P
D
A
E
L
P
D
V
N
P
A
D
L
R
I
D
------
T
F
--
R
S
S
G
A
G
G
Q
H
V
N
T
T
D
---
S
A
------
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
V
E
C
Q
D
E
R
S
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
I
--
H
A
A
--
E
M
A
K
R
Q
--------
R
R
N
-------------------
S
DRN
R
T
Y
N
F
-
P
Q
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
------
E
V
M
E
G
K
L
D
M
L
I
E
P
I
I
Q
E
H
Q
-------------------------------------------------
24
HHSearch
83.44
32%
-65
- C5 -
2B3T
-
RF1_ECOLI
B:
[14-348]
---------------------------------------------------------------------------------
E
R
H
E
E
V
Q
A
L
L
G
D
---------------
A
Q
T
I
A
D
--
Q
E
R
F
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
R
C
F
T
---
D
W
-
Q
Q
V
-----------------------------------------------------
Q
QLQV
L
-
L
L
P
K
D
P
D
D
E
R
N
A
F
L
E
------
V
R
A
G
-
T
G
G
D
E
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
A
E
-
A
-
R
R
W
R
V
E
I
M
S
A
S
E
G
E
H
G
G
---
Y
K
E
I
I
A
K
I
S
G
D
--
G
V
Y
G
R
------------
L
K
F
E
S
---
G
G
H
R
V
Q
R
V
P
A
T
E
S
Q
G
-
R
I
H
T
S
A
C
T
V
A
V
M
--------------------
P
E
L
----------------
P
D
A
E
L
P
D
V
N
P
A
D
L
R
I
D
------
T
F
--
R
S
S
G
A
G
G
Q
H
V
N
T
T
D
---
S
A
------
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
V
E
C
Q
D
E
R
S
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
I
--
H
A
A
--
E
M
A
K
R
Q
------
R
R
N
---------------
S
D
---
R
N
---
R
T
Y
N
F
P
Q
-
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
------
E
V
M
E
G
K
L
D
M
L
I
E
P
I
I
Q
E
H
Q
-------------------------------------------------
25
HHSearch
79.06
36%
-54
- C5 -
1RQ0
-
RF1_THEMA
A:
[3-324]
---------------------------------------------------------------------------------
E
K
K
K
E
I
E
K
L
L
A
R
---------------
P
D
L
T
P
E
----
Q
M
K
N
Y
G
M
E
Y
A
K
I
E
E
I
E
N
I
T
N
---
R
I
-
K
E
T
----
Q
-------
E
F
I
E
L
L
R
E
E
-----------
G
E
---
N
E
L
E
I
E
K
Y
E
K
E
L
D
Q
L
Y
Q
----
E
L
L
F
L
L
S
P
E
A
S
D
K
A
I
V
E
------
I
R
P
G
-
T
G
G
E
E
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
-
R
-
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
---
I
R
E
V
V
F
F
V
K
G
K
--
N
A
Y
G
I
------------
L
K
Y
E
S
---
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
-
R
I
H
T
S
T
A
T
V
A
V
L
--------------------
P
E
I
----------------
E
E
-
K
D
I
E
I
R
P
E
D
L
K
I
E
------
T
F
--
R
A
S
G
----
Y
V
N
K
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
--
Y
Q
L
--
Q
K
E
Q
K
E
R
E
I
S
Q
------------------R
S
E
---
K
I
---
R
T
Y
N
F
P
Q
-
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
------
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-------------------------------------------------
21
HHSearch
76.34
47%
19
- C5 -
1GQE
-
RF2_ECOLI
A:
[32-363]
---------------------------------------------------------------------------------
E
R
L
E
E
V
N
A
E
L
E
Q
---------------
P
D
V
W
N
E
--
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
---
Q
M
-
K
Q
G
L
E
D
V
S
-------
G
L
L
E
L
A
V
E
A
--
D
D
---
E
E
T
F
N
E
---
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
L
E
F
----
R
-
R
M
F
S
G
E
Y
D
S
A
D
C
Y
L
D
------
I
Q
A
G
-
S
G
G
T
E
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
-
S
-
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
---
I
K
S
V
T
I
K
I
S
G
D
--
Y
A
Y
G
W
------------
L
R
T
E
T
---
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
-
R
R
H
T
S
F
S
S
A
F
V
Y
--------------------
P
E
V
----------------
D
D
D
I
D
I
E
I
N
P
A
D
L
R
I
D
------
V
Y
--
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
--
Y
E
V
--
E
M
Q
K
K
N
A
E
K
Q
A
M
E
D
N
K
S
--------
D
I
G
W
-
G
S
---
Q
I
---
R
S
Y
V
L
D
D
-
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
------
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-------------------------------------------------
5
PsiBlast_PDB
76.10
42%
-68
- C5 -
1RQ0
-
RF1_THEMA
A:
[74-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
----
L
-
F
L
L
S
P
E
A
-
S
D
K
A
I
V
E
------
I
R
P
G
-
T
G
G
E
E
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
--
R
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
---
I
R
E
V
V
F
F
V
K
G
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--
N
A
Y
G
I
------------
L
K
Y
E
S
---
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
-
R
I
H
T
S
T
A
T
V
A
V
L
--------------------
P
E
I
----------------
E
E
K
-
D
I
E
I
R
P
E
D
L
K
I
E
------
T
F
--
R
A
S
G
----
Y
V
N
K
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
--
Y
Q
L
--
Q
K
E
Q
K
E
R
E
I
S
Q
-----------------
R
-
S
E
---
K
I
---
R
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
------
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-------------------------------------------------
3
PsiBlast_PDB
75.25
47%
21
- C5 -
1GQE
-
RF2_ECOLI
A:
[33-357]
----------------------------------------------------------------------------------
R
L
E
E
V
N
A
E
L
E
Q
---------------
P
D
V
W
N
E
--
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
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D
---
Q
M
-
K
Q
G
L
E
D
V
S
-------
G
L
L
E
L
A
V
E
A
--
D
D
---
E
E
T
F
N
E
---
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
L
E
F
----
R
-
R
M
F
S
G
E
Y
D
S
A
D
C
Y
L
D
------
I
Q
A
G
-
S
G
G
T
E
A
Q
D
W
A
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M
L
E
R
M
Y
L
R
W
A
E
--
S
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F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
---
I
K
S
V
T
I
K
I
S
G
D
--
Y
A
Y
G
W
------------
L
R
T
E
T
---
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
-
R
R
H
T
S
F
S
S
A
F
V
Y
--------------------
P
E
V
----------------
D
D
D
I
D
I
E
I
N
P
A
D
L
R
I
D
------
V
Y
--
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
--
Y
E
V
--
E
M
Q
K
K
N
A
E
K
Q
A
M
E
D
N
K
S
--------
D
I
G
W
-
G
S
---
Q
I
---
R
S
Y
V
L
D
D
S
R
-
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
------
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-------------------------------------------------
2
PsiBlast_PDB
61.85
47%
163
- C- -
1ML5
1
RF2_ECOLI
Z:
[33-357]
----------------------------------------------------------------------------------
R
L
E
E
V
N
A
E
L
E
Q
---------------
P
D
V
W
N
E
--
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
---
Q
M
-
K
Q
G
L
E
D
V
S
-------
G
L
L
E
L
A
V
E
A
--
D
D
---
E
E
T
F
N
E
---
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
L
E
F
----
R
-
R
M
F
S
G
E
Y
D
S
A
D
C
Y
L
D
------
I
Q
A
G
-
S
G
G
T
E
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
--
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
---
I
K
S
V
T
I
K
I
S
G
D
--
Y
A
Y
G
W
------------
L
R
T
E
T
---
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
-
R
R
H
T
S
F
S
S
A
F
V
Y
--------------------
P
E
V
----------------
D
D
D
I
D
I
E
I
N
P
A
D
L
R
I
D
------
V
Y
--
R
T
S
G
A
G
G
Q
H
V
N
R
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
--
Y
E
L
--
E
M
Q
K
K
N
A
E
K
Q
A
M
E
D
N
K
S
--------
D
I
G
W
-
G
S
---
Q
I
---
R
S
Y
V
L
D
D
S
R
-
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
------
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-------------------------------------------------
1
PsiBlast_PDB
61.48
47%
163
- C- -
1MI6
-
RF2_ECOLI
A:
[33-357]
----------------------------------------------------------------------------------
R
L
E
E
V
N
A
E
L
E
Q
---------------
P
D
V
W
N
E
--
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
---
Q
M
-
K
Q
G
L
E
D
V
S
-------
G
L
L
E
L
A
V
E
A
--
D
D
---
E
E
T
F
N
E
---
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
L
E
F
----
R
-
R
M
F
S
G
E
Y
D
S
A
D
C
Y
L
D
------
I
Q
A
G
-
S
G
G
T
E
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
--
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
---
I
K
S
V
T
I
K
I
S
G
D
--
Y
A
Y
G
W
------------
L
R
T
E
T
---
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
-
R
R
H
T
S
F
S
S
A
F
V
Y
--------------------
P
E
V
----------------
D
D
D
I
D
I
E
I
N
P
A
D
L
R
I
D
------
V
Y
--
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
--
Y
E
V
--
E
M
Q
K
K
N
A
E
K
Q
A
M
E
D
N
K
S
--------
D
I
G
W
-
G
S
---
Q
I
---
R
S
Y
V
L
D
D
S
R
-
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
------
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-------------------------------------------------
7
PsiBlast_PDB
54.95
31%
16
- C5 -
1ZBT
-
RF1_STRMU
A:
[102-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
K
D
P
N
D
D
K
N
I
I
L
E
------
I
R
G
A
-
A
G
G
D
E
A
A
L
F
A
G
D
L
L
N
M
Y
Q
K
Y
A
E
--
N
Q
G
W
K
F
E
V
M
E
A
S
A
N
G
V
G
G
---
L
K
E
V
V
A
M
V
S
G
Q
--
S
V
Y
S
K
------------
L
K
Y
E
S
---
G
A
H
R
V
Q
R
V
P
V
T
E
S
Q
G
-
R
V
H
T
S
-
T
A
T
V
L
V
--------------------
M
P
E
----------------
V
E
E
V
E
Y
E
I
D
P
K
D
L
R
V
D
------
I
Y
--
H
A
---------
K
V
A
---
T
A
------
V
R
I
--------------------
I
---------------------
H
------
L
-----
P
-----------------
T
-----------------
N
-------------------------
I
-
K
V
E
M
Q
E
E
R
T
Q
Q
K
N
R
D
K
A
M
K
I
I
R
A
R
V
A
D
H
F
A
--
Q
I
A
Q
D
E
Q
D
A
----------------
T
V
G
T
-
G
D
RSE
R
I
---
R
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
G
L
T
L
Q
K
L
D
------
S
I
L
S
G
K
L
D
E
V
I
D
A
L
I
L
Y
D
Q
-------------------------------------------------
40
Fugue
48.64
19%
-33
* C4 *
4TWA
11
SYP_PLAF7
A:
[3-497]
-----------------------------MAITSKKIEN
F
S
D
W
Y
T
Q
V
I
V
K
S
EL
I
E
Y
Y
DISGCYILR
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
E
I
K
K
L
N
V
E
N
S
Y
---------------
F
P
L
F
V
T
--
K
N
K
L
E
K
E
K
N
H
I
E
G
F
S
P
E
V
A
W
V
T
---
K
Y
G
D
S
N
L
P
E
E
I
AIRPTS
E
T
I
M
Y
S
V
F
P
K
WI
R
S
---
Y
R
D
L
P
L
---
K
L
N
Q
W
N
T
V
V
R
W
E
F
K
Q
P
T
----
P
-
F
I
R
T
R
E
----
F
L
W
Q
E
------
G
H
T
A
H
K
N
E
E
E
A
V
K
L
V
F
D
I
L
D
L
Y
R
R
W
Y
E
-
E
Y
L
A
V
P
I
I
K
G
I
K
S
E
G
E
K
F
G
GAN
F
T
S
T
A
E
A
F
I
S
E
NG
R
A
I
Q
A
------------
A
T
S
H
Y
LGT
N
F
A
K
M
F
K
I
E
F
E
D
E
N
E
V
K
Q
Y
V
H
Q
T
S
W
G
C
T
T
R
S
I
G
I
M
I
M
T
HGDDKGLVLP
P
N
V
SKYK
V
V
I
V
P
I
F
Y
K
TTD
E
N
A
I
H
S
Y
C
K
D
I
E
K
I
L
K
N
A
Q
I
N
C
V
Y
D
D
R
A
S
Y
S
P
G
Y
K
F
N
H
W
E
L
R
G
I
P
------
I
R
I
--------------------
E
V
G
P
K
D
L
---------------
Q
------
N
-----
N
-----------------
S
-----------------
C
-------------------------
V
-
I
V
R
R
D
N
N
E
K
C
N
V
K
K
E
S
V
L
L
E
T
Q
Q
M
L
--
V
D
I
H
K
N
L
F
L
K
A
K
K
K
L
D
D
S
I
V
Q
V
TSFSE
V
M
N
A
L
N
K
-
K
K
---
M
V
---
L
A
P
W
C
E
D
I
A
T
E
E
E
I
K
K
E
T
Q
R
L
S
L
T
--------
L
S
G
A
M
K
P
L
C
I
P
L
D
Q
P
P
M
PPNMKCFWSGKPAK
R
W
C
L
F
G
R
SY--------------------------
4
PsiBlast_PDB
48.39
42%
118
- C- -
2FVO
-
RF1_THEMA
A:
[74-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
----
L
-
F
L
L
S
P
E
A
-
S
D
K
A
I
V
E
------
I
R
P
G
-
T
G
G
E
E
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
--
R
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
---
I
R
E
V
V
F
F
V
K
G
K
--
N
A
Y
G
I
------------
L
K
Y
E
S
---
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
-
R
I
H
T
S
T
A
T
V
A
V
L
--------------------
P
E
I
----------------
E
E
K
-
D
I
E
I
R
P
E
D
L
K
I
E
------
T
F
--
R
A
S
G
---------
E
---
S
A
------
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
-----------------
G
-------------------------
I
-
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
--
Y
Q
L
--
Q
K
E
Q
K
E
R
E
I
S
Q
-----------------
R
-
S
E
---
K
I
---
R
T
Y
N
F
-
P
Q
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
------
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-------------------------------------------------
30
HHSearch
45.56
36%
-51
- C5 -
2JY9
-
?
A:
[7-102]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
I
A
D
N
E
L
E
I
T
------
A
I
--
R
A
Q
G
A
G
G
Q
H
V
N
K
T
S
---
S
A
------
I
H
L
--------------------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
-----
I
-----------------
S
DDG--------------
V
-------------------------
I
-
I
I
K
A
Q
E
F
R
S
Q
E
L
N
R
E
A
A
I
A
R
L
V
A
V
I
--
K
E
L
--
T
A
E
Q
K
S
R
R
A
T
R
P
T
R
A
S
K
--------
E
R
R
L
-
S
S
---
K
A
---
Q
K
S
S
V
K
A
L
R
G
K
V
R
R
P
L
D
L
E
H
H
H
H
H
------
H
-------------------------------------------------------------------
27
HHSearch
43.40
31%
-35
- C5 -
2JVA
-
?
A:
[7-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
H
L
P
D
A
E
I
E
L
T
------
A
I
--
R
A
Q
G
A
G
G
Q
N
V
N
K
V
S
---
S
A
------
M
H
L
--------------------
R
---------------------
F
DINASS
L
-----
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
-----------------
G
V
------------------------
I
-
V
L
K
A
Q
Q
Y
R
T
Q
E
Q
N
R
A
D
A
L
L
R
L
S
E
L
I
--
V
N
A
--
A
K
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
43.15
25%
-49
- C5 -
2RSM
-
CL065_MOUSE
A:
[4-110]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
K
---
W
G
L
R
L
Q
E
K
P
A
L
L
F
P
G
--
M
A
A
S
T
V
Q
V
A
G
R
--------------------
K
D
Y
----------------
P
--
A
L
L
P
L
N
E
S
E
L
E
E
Q
------
F
V
--
K
G
H
G
P
G
G
Q
A
T
N
K
T
S
---
N
C
------
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
-----------------
G
-------------------------
I
-
V
V
K
C
H
Q
T
R
S
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
--
D
V
F
--
Y
N
S
G
P
S
S
G
----------------------------------------------------------------------------------------------------------------------------------
36
Fugue
41.41
15%
-4
- C1 -
2I3O
-
?
D:
[2-516]
FRSRPNALSQRSVIASSSELASLAGRDILKRGGNIFDAALAVSALCVTQNNLCGLGGDLFALIRDENGQIDLNGSGQASRA
V
S
I
D
Y
Y
E
S
G
L
T
K
IPERGPYAAITVPGI
A
G
S
W
D
E
IF
R
K
F
A
T
D
I
A
D
I
L
E
P
A
I
R
T
A
S
A
G
F
---
P
I
-
T
Q
N
Y
S
D
S
I
-------
A
R
S
A
P
V
I
G
Q
--
Y
R
---
G
W
S
S
I
F
---
P
N
G
S
V
P
V
A
G
E
I
L
K
Q
P
D
L
----
A
-
E
S
F
R
L
S
E
E
G
F
R
S
F
Y
D
GSLADI
I
I
A
G
-
L
E
G
T
G
S
P
L
S
D
R
D
L
R
V
Y
R
P
L
I
G
K
P
V
F
T
D
L
D
E
F
R
I
Y
E
T
S
P
N
S
Q
G
-----
I
T
V
I
E
W
I
R
G
--
E
S
H
G
Y
DSRTWEAKIEDI
F
E
T
E
E
---
A
Y
D
K
R
R
K
I
T
D
P
S
Y
N
I
-
A
Q
H
D
S
A
N
G
K
G
L
P
--------------------
K
R
D
----------------
H
N
D
I
G
--------
D
T
T
------
Y
F
--
S
I
S
D
S
E
G
R
S
V
S
I
I
Q
---
S
N
------
Y
G
F
--------------------
G
---------------------
S
GI----
V
-----
P
-----------------
K
-----------------
G
-------------------------
T
-
G
F
V
L
Q
N
R
G
S
Y
F
T
L
Q
R
D
H
P
N
A
L
P
G
K
R
--
T
F
H
--
T
L
A
A
---
C
V
E
K
E
H
D
L
Y
A
--------
S
L
G
S
-
G
G
---
D
I
---
Q
P
Q
V
Q
Q
I
L
E
I
L
K
D
N
T
D
P
Q
A
I
L
D
K
P
RWTEPY
T
I
Y
E
A
P
G
A
V
Y
V
E
S
E
E
L
Y
R
N
VSKQISGRKVVLRDVSQEFGTAQITTLIRGDVVVGAADPRGDGIAIPYS
8
PsiBlast_PDB
41.24
36%
-21
- C5 -
2RSM
-
CL065_MOUSE
A:
[41-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
N
E
S
E
L
E
E
Q
------
F
V
--
K
G
H
G
P
G
G
Q
A
T
N
K
T
S
---
N
C
------
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
-----------------
G
-------------------------
I
-
V
V
K
C
H
Q
T
R
S
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
--
D
V
F
--
Y
N
S
G
P
S
S
G
----------------------------------------------------------------------------------------------------------------------------------
33
Fugue
38.31
22%
-2
- C5 -
1J26
-
ICT1_MOUSE
A:
[1-112]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
--------------------
G
E
H
----------------
A
K
Q
A
S
S
Y
I
P
L
D
R
L
S
I
S
------
Y
C
--
R
S
S
G
P
G
G
Q
N
V
N
K
V
N
---
S
K
------
A
E
V
--------------------
R
---------------------
F
------
H
-----
L
-----------------
A
-----------------
S
ADWIE
E
P
V
R
Q
K
I
A
L
T
HKNKINKAG
E
L
-
V
L
T
S
E
S
S
R
Y
Q
F
R
N
L
A
E
C
L
Q
K
I
R
D
M
I
--
A
E
A
--
S
G
P
S
S
G
------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
35.88
32%
-6
- C5 -
2JY9
-
?
A:
[3-106]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
----------------
S
R
T
V
S
I
A
D
N
E
--
L
E
I
T
------
A
I
--
R
A
Q
G
A
G
G
Q
H
V
N
K
T
S
---
S
A
I
H
L
R
F
D
I
R
A
--------------------
S
---------------------
G
------
L
-----
P
-----------------
E
Y
Y
K
Q
R
L
L
T
ASHHLISDD
G
-------------------------
V
I
I
I
K
A
Q
E
F
R
S
Q
E
L
N
R
E
A
A
I
A
R
L
V
A
V
I
--
K
E
L
--
T
A
E
Q
K
S
R
R
A
T
R
P
T
R
A
S
K
--------
E
R
R
L
-
S
S
---
K
A
---
Q
K
S
S
V
K
A
L
R
G
K
V
R
R
P
L
D
L
E
H
H
H
H
H
------
H
-------------------------------------------------------------------
28
HHSearch
35.35
28%
6
- C5 -
1J26
-
ICT1_MOUSE
A:
[13-108]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
S
Y
I
P
L
D
R
L
S
I
S
------
Y
C
--
R
S
S
G
P
G
G
Q
N
V
N
K
V
N
---
S
K
------
A
E
V
R
F
HLASADWIE
E
P
V
R
Q
K
I
A
L
T
---------------------
H
------
K
NKINK
A
-----------------
G
-----------------
E
-------------------------
L
-
V
L
T
S
E
S
S
R
Y
Q
F
R
N
L
A
E
C
L
Q
K
I
R
D
M
I
--
A
E
A
--
S
G
P
S
S
G
------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
35.00
28%
38
- C5 -
4C46
1
?
A:
[8-76]
----------------------------------------------------------------------------------------------------------------
Q
I
--
E
M
K
I
E
E
I
L
S
K
I
Y
H
I
E
N
E
I
A
R
I
K
---
K
L
-
I
E
A
N
D
R
E
I
-------
N
L
V
P
A
S
I
K
Q
--
I
E
W
K
I
E
E
I
L
S
K
I
Y
H
I
E
N
E
I
A
R
I
K
K
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------