@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0299: (2015-11-30 )
MNKLASLINSKSVDKEICKLPHNLEAEQMLIGAMIRDNRICDAVEDTITAENFYDPLHQSIFTQISKTRKHGIVANELSLKMFFENDQAFIECGGVEYLAKLAAKASIALDIYSLTRIIRDTYLRRCLIKLGQEMVNDSYNYDIENSAQVQIEQVMTKLFNLAVKRLGEKTYIKLASSVKDVVKKISTLKNNPEALGITTGLQDLNQLLGGLQKSDLLILAARPSMGKTALALNIALNACKVLQKRADEQHYVAFFSLEMSAEQLTTRLITIDSGISYYKALTGRISDFELHEFINASAELSELPFIIDDTPALSISALRTRIRLLYQLYNVEAVFIDYLQLIRGTTKRSNENRVQEISEVTQGLKAIAKELNIPVVALSQLSRSVEQRDDKKPQLADLRDSGSIEQDADIVMFLYREEYYELRRQPSEGSNKHREWQEKMEKIRNVAELIIAKQRNGPIGSVKLYFDSNQGAFKDYTKRHSL
Atome Classification :
(20 SA)
.........10........20........30........40.......-.50........60......-..70........80........90........100.......110.......120.-......130.......140........150.......160.......170.......180.----......-----190........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
K
L
A
S
L
I
NSK
S
V
D
K
E
I
C
KLPHNL
E
A
E
Q
M
L
I
G
A
M
IRDN
R
I
C
D
A
V
E
D
T
I
-
T
A
E
N
F
Y
D
P
L
H
Q
S
I
F
T
Q
I
S
K
-
T
RKHGIVANE
L
S
L
K
M
F
FENDQ
A
F
I
ECG
G
V
E
Y
L
A
K
L
A
AK
A
S
I
A
L
D
I
Y
S
L
T
R
I
I
R
D
T
Y
-
L
R
R
C
L
I
K
L
G
Q
E
M
VNDSY-NYDIENS
A
Q
V
Q
I
E
Q
V
M
T
K
L
F
N
L
A
V
K
RLGE
K
T
Y
I
K
L
A
S
S
V
K
D
V
V
----
K
K
I
S
T
L-----KN-NPE
A
L
G
I
T
T
G
L
Q
D
L
N
Q
L
L
GGLQKS
D
L
L
I
L
AARPSMG
K
T
A
L
A
L
N
I
A
L
N
A
C
K
V
L
Q
K
RADEQ
H
Y
V
A
F
F
S
L
EM
S
A
E
Q
L
T
T
R
L
I
T
IDSG
I
S
Y
Y
K
A
L
TGRI
S
D
F
E
L
H
E
F
I
NASAELSEL
P
F
I
IDDTPA
L
S
I
S
A
L
R
T
R
I
R
L
L
Y
Q
L
YN
V
E
A
V
F
I
D
Y
L
Q
L
I
RGTTKRS
N
E
N
R
V
Q
E
I
S
E
V
T
Q
G
L
K
A
I
A
K
ELNI
P
V
V
A
L
S
Q
L
S
R
S
V
E
Q
RDDKKPQ
L
A
DLRDSGSIEQDA
D
I
V
M
F
L
Y
R
E
E
Y
Y
E
L
RRQPSEGS
N
K
H
R
E
W
Q
E
K
M
E
K
I
R
N
V
A
E
L
I
I
AKQRNGPI
G
S
V
K
L
Y
F
DSNQ
G
A
F
K
D
Y
T
K
RHSL
34
PsiBlast_CBE
91.57
37%
-114
- C3 -
2R6E
1
?
B:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-------------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
------------------------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
5
PsiBlast_PDB
91.04
37%
-114
- C3 -
2R6E
1
?
A:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-------------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
------------------------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
62
Fugue
90.99
38%
-104
- C3 -
2Q6T
1
?
A:
[5-440]
------------------
I
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
-
L
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
-
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
-
E
E
--
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
-
A
R
P
M
R
E
L
V
H
E
T
F
----
E
H
I
E
---------------
A
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
------
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
------
P
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
S
E
K
-----------------
A
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------
27
PsiBlast_CBE
89.98
37%
-106
- C3 -
4ESV
27
?
I:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
--------------
F
K
N
I
K
D
I
L
VQTY
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
31
PsiBlast_CBE
89.92
37%
-104
- C3 -
4ESV
1
?
D:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
R
K
H
--
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
R
D
G
-
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
6
PsiBlast_PDB
89.70
37%
-105
- C3 -
4ESV
8
?
A:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
------
F
K
N
I
K
D
I
L
VQTY-----------------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
24
PsiBlast_CBE
89.66
36%
-108
- C3 -
2Q6T
1
?
B:
[7-440]
--------------------
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
-
L
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
---
R
L
-
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
------
A
R
-
P
M
R
E
L
V
H
E
T
F
----
E
H
I
E
A
L
--------------
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
------
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
---
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P
------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
----------
N
P
H
S
E
K
A
-------
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------
28
PsiBlast_CBE
89.46
37%
-102
- C3 -
4ESV
2
?
H:
[11-444]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
--------------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
R---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
--
29
PsiBlast_CBE
89.19
37%
-104
- C3 -
4ESV
1
?
G:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
25
PsiBlast_CBE
89.15
37%
-104
* C3 *
4ESV
1
?
L:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
------------
A
F
K
N
I
K
D
I
L
VQTY
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
22
PsiBlast_CBE
89.12
36%
-112
- C3 -
2Q6T
1
?
D:
[7-440]
--------------------
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
-
L
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
---
R
L
-
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
--
T
E
A
R
-
P
M
R
E
L
V
H
E
T
F
----
E
H
I
E
A
L
F---------------
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
------
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
---------------
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
-------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
----------
N
P
H
S
E
K
A
-------
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------
4
PsiBlast_PDB
89.07
37%
-111
- C3 -
2R6A
2
?
A:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
------------------------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
33
PsiBlast_CBE
88.93
37%
-104
- C3 -
4ESV
3
?
B:
[11-444]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
--
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
--------
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
--
40
HHSearch
88.86
38%
-113
- C3 -
2R6A
2
?
A:
[8-441]
-----------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
-
D
E
-
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
-
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
----
D
N
I
E
M
L
H
----
N
R
-
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
------
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
------------------------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
32
PsiBlast_CBE
88.75
37%
-103
- C3 -
4ESV
4
?
C:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
30
PsiBlast_CBE
88.70
37%
-105
- C3 -
4ESV
4
?
F:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
7
PsiBlast_PDB
88.10
35%
-105
- C3 -
4NMN
3
?
A:
[2-428]
--------------------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
Y
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
-
K
N
L
L
Q
---
I
D
W
L
E
E
L
Y
E
E
A
V
S
P
D
T
L
E
E
V
C
K
I
V
K
Q
R
S
-
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
F
----
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
--
S
T
Q
F
Y
-----
H
V
K
D
V
A
----
E
E
V
I
E
L
I
Y
K
F
K
S
S
-
D
R
L
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
------
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
E
K
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
P
V
R
K
S
P
--
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
R
E
V
E
K
R
S
D
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
K
K
P
N
--
E
---------------
Q
G
I
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
------
I
K
E
Y
T
K
F
A
N
L
1
PsiBlast_PDB
88.05
38%
-108
- C- -
2VYE
1
?
A:
[11-441]
--------------------
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
T
A
L
T
L
A
S
E
R
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
K
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
L
E
Q
L
E
E
V
G
G
V
S
Y
L
S
E
L
A
D
S
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
L
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
E
R
K
I
M
E
V
S
-----
Q
R
K
H
S
G
A
F
K
N
I
K
D
V
L
V
Q
T
Y
D
N
I
E
M
L
-----
H
N
R
N
G
D
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
V
V
I
D
Y
L
Q
L
I
Q
G
S
-
G
R
N
R
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
--
P
M
M
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
------------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
----
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
26
PsiBlast_CBE
88.04
37%
-105
- C3 -
4ESV
26
?
J:
[14-441]
-----------------------
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
-
V
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
-
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
--
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----
Q
------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
----
K
T
N
E
N
--
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
-
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
----------
N
K
D
S
E
N
-------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------
23
PsiBlast_CBE
87.27
36%
-113
- C3 -
2Q6T
1
?
C:
[7-440]
--------------------
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
-
L
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
---
R
L
-
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
-
P
M
R
E
L
V
H
E
T
F
----
E
H
I
-------------------
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
------
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
----------
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P
------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
----------
N
P
H
S
E
K
A
-------
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------