@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0452: (2015-12-01 )
MNAALYHKEYGYYMNKLPLGNGGDFITAPEISQLFGEIIAVWVMHTWKKLGKPSKFSLVELGPGRGTLIHDIIRVTKKYGSFFSSMAIHLVEISPTLQKIQKEKLKGLEISWHENIDSLPEQPTIFLANEFFDALPIDQFVYRNGKWHENRVTKQNDGASSQCPFLVTPLLNTRIQKKDPSKLALKSRKKNVVTSLSLSCHPSAPSFLSHCLTLGSRKIDRKQAHYSTFSMKLQKNWIPVSSNGMTEGFDGAVVEVCSAGIEVLKKLEDKIMNNGGAALIIDYGYVYPSHKSTLQSVRQHKYANFLENVGNSDITALVNFQALRDSLRYVDCEISTQREFLYLFGIKERTQALMENASDEQKNRIFSEFLRLTENMGTLFKAILIHHS
Atome Classification :
(20 SA)
-------.--........10.-----.....-.-----.20.....------------------.--..30........--40-----........50....----------....-60--.......------..70......---------------..80--.....------...90.---.......100--...----.---.--------.--.-110......---.120---.......130..----------...------..140.......150.......160....-----------...170....------------...180-----------------..----------..----------....190....-...200..--------.--....-210.-..--....220.......230.......240-.-.......250.......260.......270.......280-----------.......----.290......-----.300---....------.....310..---------....------.320...-.-...330----------...---.--------....340.---....---------...350.......360......---------.------.370-...----.--------.....380-----......------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------M--NA
A
L
Y
H
K
E
Y
G
Y
-----
Y
M
NKL-P-----LGNGGDFI------------------T--
A
P
E
I
S
Q
L
F
G
E
I
I
--
A
V
-----
W
V
M
H
T
W
K
KLGKPS
K
----------
F
S
L
V
-
E
---LGPG
R
G
T
------
L
I
H
D
I
I
R
V
T
K
---------------
K
Y
G
S
--
F
F
S
S
M
------
A
I
H
L
V
E---I
S
P
T
L
Q
K
I
Q
K
--EKL----K---G--------
L
--
E
-
I
S
WHE
N
I
DS---LPEQ---
P
T
I
F
L
A
N
E
F
F
D
A----------LP
I
------
D
Q
F
V
YRNGKWHENRVTKQNDGASSQC
P
F
L
-----------
V
T
P
L
LNTRIQ------------KKD
P
S
------------------
K
L
----------
A
L
----------
K
S
RKK
N
V
V
T
S
L
-
S
L
SCHPS
A
--------
P
--
S
F
L
S
-
H
C
L
T
-LG--SRKI
D
R
K
Q
AHYS
T
F
S
M
K
L
Q
K
N
W
I
PVS--S-NGMTEGFD
G
A
V
V
E
V
C
S
A
G
I
E
V
L
K
K
L
E
D
K
I
MNNGG
A
A
L
I
I
------------
D
Y
G
Y
VYP----S
H
K
S
T
L
Q
S
V
R
-----
Q
H
-----
K
Y
A
N
------
F
L
E
N
VGNS
D
I
---------
T
A
L
V
------
N
F
Q
A
L
R
D-S-L
R
Y
V
D
-----------
C
E
I---S--------TQ
R
E
F
L
-
Y
---
L
FGI---------
K
E
R
T
Q
A
L
M
ENAS
D
E
-
Q
K
N
R
I
F
S
---------
E
------
F
L
---
R
L
T
----
E
--------
N
M
G
T
L
F
K
A
-----
I
L
IHHS------------
21
HHSearch
70.65
37%
4
- C4 -
1ZKD
-
?
A:
[27-354]
-------
M
--
E
L
C
L
G
H
P
E
H
G
Y
-----
Y
V
T
R
--------------
F
T
------------------
T
--
S
P
E
I
S
Q
M
F
G
E
L
L
--
G
L
-----
W
S
A
S
V
W
K
A
A
D
E
P
Q
T
----------
L
R
L
I
-
E
---
I
G
P
G
R
G
T
------
M
M
A
D
A
L
R
A
L
R
---------------
V
L
P
I
--
L
Y
Q
S
L
------
S
V
H
L
V
E
---
I
N
P
V
L
R
Q
K
Q
Q
--
T
L
L
----
A
---
G
I-------
R
--
N
-
I
H
W
H
D
S
F
E
D
---
V
P
E
G
---
P
A
V
I
L
A
N
E
Y
F
D
V
----------
L
P
I
------
H
Q
A
I
K
R
E
T
G
W
H
E
R
V
I
E
I
G
A
S
G
E
-----------------------------------------------------------------------------------------------
L
V
F
-
G
V
A
A
D
P
I
P
--------
G
--
F
E
----------------------------
A
L
L
P
P
L
A
----------
R
L
S
P
P
G
A
V
F
E
W
R
P
D
T
E
--
I
L
K
I
A
S
R
V
R
D
Q
G
G
A
A
L
I
I
------------
D
Y
G
H
L
R
S
----
D
V
G
D
T
F
Q
A
I
A
-----
S
H
-----
S
Y
A
D
------
P
L
Q
H
P
G
R
A
D
L
---------
T
A
H
V
------
D
F
D
A
L
G
R
-
A
-
A
E
S
I
G
-----------
A
R
A
H
G
P
V
--------
T
Q
G
A
F
L
-
K
---
R
L
G
I
---------
E
T
R
A
L
S
L
M
A
K
A
T
P
Q
-
V
S
E
D
I
A
G
---------
A
------
L
Q
---
R
L
T
GEGR
G
--------
A
M
G
S
M
F
K
V
-----
I
G
V
S
D
P
------------
3
PsiBlast_PDB
67.20
29%
-91
- C4 -
4G67
3
?
A:
[82-244]
-------
M
--
E
R
V
L
Y
A
P
G
M
G
Y
-----
Y
S
G
G
A
-
Q
KFGRR
A
D
D
G
S
D
F
V
------------------
T
--
A
P
E
L
S
P
L
F
A
Q
T
L
--
A
R
-----
P
V
A
Q
A
L
D
A
S
G
---
T
----------
R
R
V
M
-
E
---
F
G
A
G
T
G
K
------
L
A
A
G
L
L
T
A
L
A
---------------
A
L
G
V
--
E
L
D
E
Y
------
A
I
--
V
D
---
L
S
G
E
L
R
A
R
Q
R
--
E
T
L
G
A
Q
A
P
---
G
--------
L
AA
R
-
V
R
W
---
L
D
A
---
L
P
E
R
F--
E
G
V
V
V
G
N
E
V
L
D
A
----------
M
P
V
------
R
L
V
A
K
Q
A
R
G
W
C
E
R
G
V
S
I
D
D
A
G
A
F
V
F
A
D
R
P
-----------
F
A
R
A
E
E
A
A
R
L
------------
A
G
I
D
A
------------------
D
E
----------
G
Y
----------
V
T
E
T
H
D
A
A
V
A
F
-
V
R
T
V
C
A
M
L
--------
A
--
R
G
A
A
-
F
F
I
D
-
Y
G
--
F
P
S
H
E
Y
Y
H
R
Q
R
A
Q
G
T
L
M
C
H
Y
R
H
R
A
H
G
--
D
-
P
F
V
Y
P
G
L
Q
D
I
T
A
H
V
E
F
S
A
I
H
E
A
G
V
G
A
G
A
D
L
L
G
Y
T
S
Q
A
R
F
------------
L
L
N
A
G
I
T
----
D
V
L
A
E
I
D
P
S
D
-----
A
Q
-----
H
F
L
P
------
A
A
N
A
V
Q
K
L
I
S
---------
E
A
E
M
------
G
E
L
F
K
V
I
-
A
-
F
S
R
G
I
-----------
D
G
A
---
L
--------
D
A
F
A
R
G
-
D
---
R
S
H
T
---------
L
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.79
29%
-113
- C4 -
4F3N
1
?
A:
[82-244]
-------
M
--
E
R
V
L
Y
A
P
G
M
G
Y
-----
Y
S
G
--------------
D
F
V
------------------
T
--
A
P
E
L
S
P
L
F
A
Q
T
L
--
A
R
-----
P
V
A
Q
A
L
D
A
S
G
---
T
----------
R
R
V
M
-
E
---
F
G
A
G
T
G
K
------
L
A
A
G
L
L
T
A
L
A
---------------
A
L
G
V
--
E
L
D
E
Y
------
A
I
--
V
D
---
L
S
G
E
L
R
A
R
Q
R
--
E
T
L
G
A
QA
P
---
G
--------
L
AA
R
-
V
R
W
---
L
D
A
---
L
P
E
R
F--
E
G
V
V
V
G
N
E
V
L
D
A
----------
M
P
V
------
R
L
V
A
K
Q
A
R
G
W
C
E
R
G
V
S
I
D
D
A
G
A
F
V
F
A
D
R
P
-----------
F
A
R
A
E
E
A
A
R
L
------------
A
G
I
D
A
------------------
D
E
----------
G
Y
----------
V
T
E
T
H
D
A
A
V
A
F
-
V
R
T
V
C
A
M
L
--------
A
--
R
G
A
A
-
F
F
I
D
-
Y
G
--
F
P
S
H
E
Y
Y
H
R
Q
R
A
Q
G
T
L
M
C
H
Y
R
H
R
A
H
G
--
D
-
P
F
V
Y
P
G
L
Q
D
I
T
A
H
V
E
F
S
A
I
H
E
A
G
V
G
A
G
A
D
L
L
G
Y
T
S
Q
A
R
F
------------
L
L
N
A
G
I
T
----
D
V
L
A
E
I
D
P
S
D
-----
A
Q
-----
H
F
L
P
------
A
A
N
A
V
Q
K
L
I
S
---------
E
A
E
M
------
G
E
L
F
K
V
I
-
A
-
F
S
R
G
I
-----------
D
G
A
---
L
--------
D
A
F
A
R
G
-
D
---
R
S
H
T
---------
L
-----------------------------------------------------------------------------------------
44
Fugue
56.47
18%
-48
- C2 -
4QA5
9
HDAC8_HUMAN
A:
[14-377]
------L
V
--
P
V
Y
I
Y
S
P
E
Y
V
S
-----
M
C
D
S
L
-
A
-----
K
----------------------------
I
P
K
R
A
S
M
V
H
S
L
I
--
E
A
-----
Y
A
L
H
K
Q
M
R
I
V
K
P
K
V
----------
A
S
M
E
-
E
---
M
A
T
-----------
F
H
T
-----------------------------
D
A
Y
------
L
Q
H
L
Q
K
---
V
S
Q
E
G
D
D
D
H
P
--
D
S
I
----
E
YGL
G
--------
Y
--
D
-
C
P
A
T
E
G
I
F
D
---
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
G
----------
M
-
C
------
K
V
A
I
N
W
S
G
G
W
H
----
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
-----------
D
A
V
L
G
I
L
R
L
R
------------
R
K
F
E
R
------------------
I
L
Y
V
D
LDLHHG
D
G
V
----------
E
D
T
F
S
F
T
S
K
V
M
-
T
V
S
L
H
K
F
S
--------
P
--
G
F
F
P
-
G
--
T
-
G
D
--
V
S
D
V
G
L
G
K
G
R
Y
Y
S
V
N
V
P
I
Q
-----------
D
G
I
Q
---
D
E
K
Y
Y
Q
I
C
E
S
---
V
L
K
E
V
Y
Q
A
F
-
N
P
K
A
V
V
L
Q
L
------------
G
A
D
T
I
A
G
----
D
P
M
C
S
F
-
N
M
T
-----
P
V
-----
G
I
G
K
------
C
L
K
Y
I
L
Q
W
Q
L
---------
A
T
L
I
L
G
G
G
GF
N
L
A
N
T
A
R
-
C
-
W
T
Y
L
T
-----------
G
V
I
---
L
G
K
T
L
S
SEI
P
D
H
E
F
F
-
T
---
A
Y
G
P
---------
D
Y
V
L
E
I
T
P
S
C
R
P
D
R
N
E
P
H
R
I
Q
Q
---------
I
------
L
N
---
Y
I
K
----
G
--------
N
L
K
H
V
V
-------------------------
47
Fugue
53.41
20%
-52
- C5 -
4XGC
-
A:
[38-388]
------P
C
--
R
E
R
E
F
E
N
I
Y
A
F
-----
L
E
G
K
I
-
Q
-----
D
Q
-----------------------------------------
C
M
-----
Y
V
S
------
G
V
P
G
T
----------------------
G
K
T
A
------
T
V
T
G
V
I
R
T
L
Q
---------------
E
Y
L
E
--
I
N
G
M
---------
R
L
T
E
---
P
R
Q
A
Y
V
Q
I
Y
K
--
Q
L
-----
T
---
G
--------
K
--
T
-
V
S
W
E
Q
A
H
A
L
---
L
E
K
R
---
T
T
V
L
L
V
D
E
-
L
D
I
----------
L
C
N
R
R----
Q
D
V
V
Y
N
L
L
D
W
P
T
K
--------------
L
V
-----------
V
V
T
I
A
N
T
---------------------------------------
M
----------
D
L
----------
P
E
R
L
G
L
T
R
L
T
F
-
Q
P
Y
S
H
K
Q
L
--------
Q
--
E
I
V
T
-
A
R
L
G
-
K
G
E
A
V
Q
L
V
A
R
K
V
A
A
V
S
-----------------------
G
D
A
R
R
A
L
D
I
C
R
R
A
T
E
I
A
D
T
A
A
V
K
C
V
T
----
M
L
H
V
------------
Q
Q
A
L
A
E
M
----
I
A
S
A
K
V
Q
A
I
R
-----
N
--------
C
S
------
R
M
E
Q
I
F
L
Q
A
I
---------
A
A
E
V
------
T
R
T
G
V
E
E
-
T
T
F
M
G
V
Y
-----------
Q
Q
V
---
E
--------
T
I
A
A
F
M
G
V
---
T
F
P
P
---------
P
G
R
A
L
R
L
C
S
K
L
G
A
E
---
R
L
I
I
S
---------
E
HSRNDL
F
Q
---
K
I
L
----
L
--------
N
V
S
A
D
D
I
H
-----
Y
A
L
R
V
-------------
1
PsiBlast_PDB
53.36
43%
-34
- C4 -
1ZKD
-
?
A:
[31-192]
-------------
L
G
H
P
E
H
G
Y
-----
Y
V
T
R
--------------
F
T
------------------
T
--
S
P
E
I
S
Q
M
F
G
E
L
L
--
G
L
-----
W
S
A
S
V
W
K
A
A
D
E
P
Q
T
----------
L
R
L
I
-
E
---
I
G
P
G
R
G
T
------
M
M
A
D
A
L
R
A
L
R
---------------
V
L
P
I
--
L
Y
Q
S
L
------
S
V
H
L
V
E
---
I
N
P
V
L
R
Q
K
Q
Q
--
T
L
L
----
A
---
G
--------
I
--
R
N
I
H
W
H
D
S
F
E
D
---
V
P
E
G
---
P
A
V
I
L
A
N
E
Y
F
D
V
----------
L
P
I
------
H
Q
A
I
K
R
E
T
G
W
H
E
R
V
I
---
E
I
G
A
S
G
E
L
V
F
G
-----------
V
A
A
D
P
I
P
G
F
E
------------
A
L
L
P
P
------------------
L
A
----------
R
L
----------
S
P
P
G
A
V
F
E
W
R
P
-
D
T
E
I
L
K
I
A
--------
S
--
R
V
R
D
-
Q
G
G
A
-
A
L
--
I
I
D
Y
G
H
L
R
S
D
V
G
D
T
F
Q
A
I
A
S
H
S
Y
A
D
P
--
L
-
Q
H
P
G
R
A
D
L
T
A
H
V
D
F
D
A
L
G
R
A
A
E
S
I
G
A
R
A
H
G
P
V
T
Q
G
A
F
L
K
------------
R
L
G
I
E
T
R
----
A
L
S
L
M
A
K
A
T
P
-----
Q
V
-----
S
E
D
I
------
A
G
A
L
Q
R
L
T
G
E
---------
G
R
G
A
------
M
G
S
M
F
K
V
-
I
-
G
V
S
D
P
-----------
K
I
E
---
T
--------
L
V
A
L
S
D
-
D
----------------------------------------------------------------------------------------------------------
50
Fugue
52.86
16%
-42
- C3 -
4TXD
1
?
A:
[21-369]
-------
K
--
R
D
V
L
A
E
L
G
L
G
D
-----
L
R
P
Y
L
R
S
-----
I
G
D
K
D
R
I
F
------------------
P
--
K
A
H
------
R
I
E
--
V
V
-----
F
L
V
R
A
------
A
N
Y
----------
L
L
L
R
-
T
---
E
G
A
G
T
----------
I
N
M
T
T
L
E
Y
---------------
S
G
G
------
A
M
------
E
V
P
V
I
Q
----
P
Q
K
L
M
A
V
T
R
--
R
Q
M
----
L
---
Q
--------
L
--
L
-
R
E
Y
R
D
S
L
D
------
E
V
---
S
K
R
W
L
V
Q
E
V
I
G
K
----------
A
K
D
------
L
G
F
K
K
V
S
E
E
W
N
C
T
--
I
Q
G
M
D
G
F
C
P
H
C
T
I
F
-----------
G
A
A
L
T
E
Q
H
N
E
------------
K
F
G
G
L
------------------
S
I
----------
G
I
----------
K
T
R
---
V
R
F
D
P
-
A
F
A
T
Q
R
R
I
--------
T
--
P
E
T
H
-
N
K
V
T
-
E
G
--
H
L
S
M
T
G
-
Q
A
L
F
S
E
V
H
V
E
P
G
T
V
F
I
G
R
A
--
E
L
V
D
L
T
E
--
P
E
L
V
A
T
L
Y
S
L
A
--
T
L
R
E
L
G
G
R
---
S
G
----------------------
I
Y
G
----
T
V
R
V
E
I
L
G
V
K
-----
A
G
-----
K
Y
A
S
TT
A
Y
D
L
A
A
E
N
A
G
K
G
Y
E
---------
E
V
K
K
------
N
L
K
E
R
L
E
-
K
-
L
G
F
T
P
-----------
V
D
----------------------------------------
N
S
K
L
L
A
A
V
D
H
K
-
D
P
N
G
L
F
K
---------
D
------
L
W
---
R
S
S
----
I
--------
D
F
A
E
K
M
V
K
-----
W
V
E
E
L
K
GGG---------
49
Fugue
50.33
19%
-39
- C1 -
4ZOX
-
SQT1_YEAST
A:
[3-381]
-------
M
SN
N
S
L
T
Y
F
D
K
H
T
D
-----
S
V
F
A
I
-
G
-----
H
H
P
N
L
P
L
V
------------------
C
--
T
G
G
G
D
N
L
----------------
A
H
L
W
T
S
H
S
Q
P
P
K
----------
F
A
G
T
-
L
---
T
G
Y
G
E
S
V
------
I
S
C
S
F
T
-------------------
S
E
G
G
--
F
L
V
T
A
D
MSG
K
V
L
V
H
M
G
Q
---
K
G
G
A
Q
W
K
L
A
S
--
Q
M
Q
----
E
---
V
--------
E
--
E
-
I
V
W
L
K
T
H
P
T
---
I
A
-
R
---
T
F
A
F
G
A
T
D
--
G
S
----------
V
W
C
------
Y
Q
I
N
E
Q
D
G
S
-------------------------------
L
E
Q
L
M
S
G
F
V
H
------------
Q
Q
D
C
S
------------------
M
G
----------
E
F
----------
I
N
T
D
K
G
E
N
T
L
E
-
L
V
T
C
S
L
D
S
--------
T
--
I
V
A
W
-
N
C
F
T
G
Q
Q
--
L
F
K
I
T
Q
A
E
I
K
------
G
L
E
A
P
W
I
S
L
S
L
A
P
-
E
T
L
T
K
G
N
S
G
V
V
A
C
G
S
N
N
G
L
L
A
V
I
N
C
-----
N
N
G
G
A
I
L
H
L
------------
S
T
V
I
E
L
K
PEQD
E
L
D
A
S
I
E
S
I
S
-----
W
S
-----
S
K
F
S
------
L
M
A
I
G
L
V
C
G
E
---------
I
L
L
Y
------
D
T
S
A
W
R
V
-
R
-
H
K
F
V
------------
L
E
D
---
S
--------
V
T
K
L
M
F
-
D
ND
D
L
F
A
S
---------
C
I
N
G
K
V
Y
Q
F
N
A
R
T
G
-
Q
E
K
F
V
C
V
GHNMGVL
D
F
I
------
L
L
---
H
P
V
----
A
--------
N
T
G
T
E
Q
K
R
-----
K
V
I
T
A
G
DEG
V
S
L
V
F
E
V
P
N
46
Fugue
50.23
16%
-51
* C3 *
4O2X
-
MALE_ECOLI
A:
[5-483]
EG
K
L
V
I
W
I
--
N
G
D
K
G
Y
N
G
L
A
E
-----
V
G
K
K
F
-
E
-----
K
D
T
G
I
K
V
T
------------------
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
--
A
T
GDGPD
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
----------
S
G
L
L
A
E
---
I
T
P
D
K
A
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
Y
N
G
---------------
K
L
I
A
--
Y
P
I
A
V
E
-----
A
L
S
L
I
Y
---
N
K
D
L
L
P
N
P
P
K
TW
E
E
I
----
P
---
A
--------
L
--
D
-
K
E
L
K
A
K
G
K
S
---
A
L
-------
M
F
N
L
Q
E
P
Y
F
T
----------
W
P
L
I
A
A
DGG
Y
A
F
K
Y
E
N
G
K
Y
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
-----------
V
D
L
I
K
N
K
H
M
N
ADTD
Y
S
I
A
E
A
A
F
N
K
G
E
T
------------------
A
M
----------
T
I
N
G
PWA
W
S
N
I
D
T
S
K
V
N
Y
G
V
T
V
L
P
T
F
K
G
Q
P
S
K
--------
P
F
V
G
V
L
S
-
A
G
I
N
-
A
A
--
S
P
N
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
-
D
E
G
L
E
A
V
N
--
K
-
D
K
P
L
G
A
V
A
L
K
S
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
------------
Q
M
S
A
F
W
Y
----
A
V
R
T
A
V
I
N
A
A
S
GRQT
V
D
-----
E
A
L
A
------
A
A
Q
T
N
A
A
A
N
L
---------
E
K
I
K
------
K
L
R
N
V
I
T
-
S
-
A
W
K
V
I
-----------
L
Y
N
---
D
--------
D
I
H
N
F
T
-
Y
---
V
T
D
V
I
V
K
V
V
GQIS
K
A
K
A
H
T
I
T
V
E
A
H
S
T
-
G
Q
A
L
I
L
S
---------
T
------
W
K
---
S
K
A
----
E
--------
K
Y
C
Q
E
L
Q
Q
N
G
L
T
V
S
I
I
H
E
S
------------
45
Fugue
47.58
18%
-53
- C- -
3WPU
2
?
A:
[3-540]
---GLQD
G
--
P
E
P
T
I
H
T
Q
Q
A
Y
APEDD
F
T
A
K
W
-
T
-----
R
A
D
A
R
Q
L
Q
R
M
SDPTAPSRENSMPASV
T
--
M
P
T
V
P
Q
D
F
P
D
M
S
NE
Q
V
-----
W
V
W
D
T
W
P
L
T
D
E
D
A
N
Q
Y
S
V
NG
W
E
I
I
F
S
L
V
-
A
DRN
L
G
F
D
D
R
H
------
V
F
A
K
I
G
Y
F
Y
R
P
AGVPAAERPENGGW
T
Y
G
G
LV
F
K
E
G
V
------
T
G
Q
I
F
E
DQS
F
S
H
Q
T
Q
W
S
G
S
--
A
R
V
----
S
---
K
NGEIK
L
F
F
T
--
D
-
V
A
F
Y
R
N
S
D
G
TNI
K
P
Y
D
---
P
R
I
A
L
S
V
G
K
V
K
A
N
KKGVTLTGF
N
K
V
------
T
D
L
L
Q
A
D
G
T
Y
Y
Q
T
--
G
A
Q
N
E
F
F
N
F
R
D
P
F
T
F
E
D
PAHPG
E
T
F
M
V
F
E
G
N
S
A
M
Q
------------
R
E
T
A
T
C
N
EADLGYRQGDPYAET
V
D
D
----------
V
N
----------
A
S
G
A
T
Y
Q
I
G
N
V
-
G
L
A
K
A
K
N
K
QLT
E
W
E
F
L
P
--
P
I
L
S
A
N
C
V
T
-
D
Q
--
T
E
R
P
Q
I
Y
F
K
D
G
K
S
Y
L
F
T
I
S
H
R
G
T
F
A
A
--
G
-
L
D
G
P
E
G
V
Y
G
F
V
G
D
G
I
R
S
D
Y
Q
P
L
---------
N
G
G
S
G
L
A
L
GNPTNLNFLGGQ
P
F
A
P
D
F
N
----
Q
H
P
G
H
F
Q
A
Y
S
-----
H
Y
V
M
P
GG
L
V
Q
S
------
F
I
D
T
I
G
T
H
D
D
F
V
R
G
GTLAP
T
V
K
M
------
D
I
G
V
G
G
D
P
T
-
K
T
A
V
D
YSYGSEGLGGW
A
D
I
---
P
--------
A
N
K
H
L
F
-
T
---
N
G
K
F
---------
G
V
A
V
S
D
E
A
A
Q
K
I
R
K
-
I
L
G
S
K
F
D
---------
D
------
Y
L
D
GK
P
V
S
----
A
--------
T
V
R
A
L
I
E
K
-----
L
L
A
Q
Y
-------------
42
Fugue
46.05
9%
-43
* C5 *
2VDW
2
MCEL_VACCW
A:
[3-302]
----------------
D
K
F
R
L
-----
N
P
E
V
S
-
Y
-----
F
T
N
K
R
T
R
G
------------------
P
--
L
G
I
L
S
N
Y
V
K
T
L
L
--
I
S
-----
M
Y
C
S
K
-
T
F
L
D
D
S
N
K
----------
R
K
V
L
-
A
---
I
D
F
G
N
G
A
---------
D
L
E
K
Y
F
Y
---------------
G
E
I
A
--
L
L
V
A
T
------
D
P
D
A
D
A
---
I
A
R
G
N
E
R
Y
N
K
--
L
N
S
----
K
---
Y
--------
Y
--
K
-
F
D
Y
I
Q
E
-----------------------------------------------------------------------
T
I
-----------
R
S
D
T
F
V
S
S
V
R
------------
E
V
F
Y
F
------------------
G
---------------------------
K
F
N
I
I
D
W
-
Q
F
A
I
H
Y
S
---------------------------------------
F
H
P
R
H
Y
A
T
V
M
N
N
L
--
S
-
E
L
T
A
S
G
--
G
K
V
L
I
T
T
M
D
G
D
K
L
S
K
L
T
D
K
K
T
F
I
I
H
K
N
L
P
-----------------
S
S
E
N
----
Y
M
S
V
E
K
I
A
D
D
-----
R
I
-----
V
V
Y
N
------
P
S
T
M
S
T
P
M
T
E
---------
Y
-
I
I
------
K
K
N
D
I
V
R
-
V
-
F
N
E
Y
G
-----------
F
V
L
---
V
--------
D
N
V
D
F
A
-
T
---
I
I
E
R
---------
S
K
K
F
I
N
G
A
S
T
M
E
D
R
-
P
S
T
R
N
F
F
---------
E
------
L
N
---
R
G
A
----
I
K
CEGLD
V
E
D
L
L
S
Y
Y
V
V
-----
Y
V
F
S
K
R
------------
27
HHSearch
44.76
14%
-55
- C4 -
2F8L
2
?
A:
[104-174]
----------------------------------------
Q
V
N
H
Q
M
------------------
T
--
P
D
S
I
G
F
I
V
A
Y
L
L
--
E
---------
K
V
I
Q
---
K
K
K
N
----------
V
S
I
L
-
D
---
P
A
C
G
T
A
N
------
L
L
T
T
V
I
N
Q
L
E
---------------
L
K
G
D
----
V
D
V
------
H
A
S
G
V
D
---
V
D
D
L
L
I
S
L
A
L
--
V
G
A
----
D
---
L
--------
Q
--
R
-
Q
K
M
T
L
L
H
Q
D
---
G
L
A
N
---
L
L
V
D
P
V
D
V
V
I
S
D
----------
L
P
V
------
G
Y
Y
P
D
D
E
N
A
K
T
F
E
L
C
R
E
E
G
H
S
F
A
H
F
L
F
I
E
-----------
Q
G
M
R
Y
T
K
P
G
G
------------
Y
L
F
F
L
------------------
V
P
----------
D
A
----------
M
F
G
T
S
D
F
A
K
V
D
-
K
F
I
K
K
N
G
H
--------
I
--
E
G
I
I
-
K
L
P
E
-
T
L
--
F
K
S
Q
A
R
K
S
I
L
I
L
E
K
A
D
V
D
V
K
P
P
K
E
V
L
--
L
-
A
N
L
S
S
L
T
D
P
S
V
T
A
P
I
L
A
E
I
E
N
W
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
44.10
29%
-66
- C4 -
3TQS
-
RSMA_COXBU
A:
[13-74]
-------------------------------------------
H
F
L
------------------
H
--
D
S
F
V
L
Q
K
I
V
S
A
I
--
H
-------------
P
---
Q
K
T
----------
D
T
L
V
-
E
---
I
G
P
G
R
G
A
------
L
T
D
Y
L
L
T
E
C
--------------------------
D
------
N
L
A
L
V
E
---
I
D
R
D
L
V
A
F
L
Q
--
K
K
Y
----
N
---
Q
--------
Q
--
K
-
N
I
T
I
Y
Q
N
D
A
---
L
Q
F
D
---
F
S
S
V
K
T
D
K
P
L
R
V
----------
V
G
N
------
L
P
Y
N
I
S
T
P
L
L
F
H
L
F
S
Q
I
H
C
I
E
D
M
H
F
M
L
Q
K
-----------
E
V
V
R
R
I
T
A
E
V
------------
G
S
H
D
Y
------------------
G
R
----------
L
S
----------
V
M
A
Q
Y
F
C
D
N
T
Y
-
L
F
T
V
S
P
Q
A
--------
F
--
T
P
P
P
-
R
V
E
S
-
A
I
--
I
R
L
I
P
R
H
N
F
T
P
V
A
K
N
L
D
Q
L
S
H
V
V
K
E
A
--
F
-
S
Y
R
R
K
T
V
G
N
A
L
K
K
L
I
N
P
S
Q
W
P
L
L
E
I
N
P
Q
L
R
P
Q
E
L
T
V
E
D
F
------------
V
K
I
S
N
I
L
----
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
42.04
17%
-48
- C4 -
2H1R
-
?
A:
[2-62]
-------------------------------------------
H
L
L
------------------
K
--
N
P
G
I
L
D
K
I
I
Y
A
A
--
K
----------------
I
K
S
S
----------
D
I
V
L
-
E
---
I
G
C
G
T
G
N
------
L
T
V
K
L
L
P
L
--------------------------
A
K
------
K
V
I
T
I
D
---
I
D
S
R
M
I
S
E
V
K
--
K
R
C
----
L
---
Y
--------
E
--
G
-
Y
N
N
L
E
V
A
I
K
---
T
V
F
P
---
K
F
D
V
C
T
A
N
I
P
Y
K
----------
I
S
S
------
P
L
I
F
K
L
I
S
H
R
P
L
F
K
C
A
V
L
M
F
Q
K
E
F
A
E
R
M
L
-----------
A
N
V
G
D
S
N
Y
S
R
------------
L
T
I
N
V
------------------
K
L
----------
F
C
----------
K
V
T
K
V
C
N
V
N
R
S
-
S
F
N
P
P
P
K
V
--------
D
--
S
V
I
V
-
K
L
I
P
-
K
E
--
S
S
F
L
T
N
F
D
E
W
D
N
L
L
R
I
C
F
S
R
K
R
K
T
L
H
--
A
-
I
F
K
R
N
A
V
L
N
M
L
E
H
N
Y
K
N
W
C
T
L
N
K
Q
V
P
V
N
F
P
F
K
K
Y
C
L
D
V
L
------------
E
H
L
D
M
C
E
----
K
R
S
I
N
L
D
E
N
D
-----
F
L
-----
K
L
L
L
------
E
F
N
K
K
G
I
H
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
41.73
10%
-22
- C5 -
1ZQ9
1
DIM1_HUMAN
A:
[8-285]
-----------------------------------------
Q
H
I
L
K
------------------
N
--
P
L
I
I
N
S
I
I
D
K
A
-------------------
A
L
R
P
T
----------
D
V
V
L
-
E
---
V
G
P
G
T
G
N
------
M
T
V
K
L
L
E
K
A
K
--------------------------------
K
V
V
A
C
E
---
L
D
P
R
L
V
A
E
L
H
--
K
R
V
----
Q
---
G
--------
T
--
P
-------------------------------------------
V
A
------
S
K
L
Q
V
L
V
G
D
V
L
K
T
D
L
P
F
F
D
T
C
V
A
N
L
P
Y
Q
I
-----------
S
S
P
F
V
F
K
L
L
L
------------
H
R
P
F
F
------------------
R
C
----------
A
I
----------
L
M
F
Q
R
E
F
A
L
R
L
-
V
A
K
P
G
D
K
L
--------
Y
--
C
R
L
S
-
I
N
T
Q
-
L
L
--
A
R
V
D
H
L
M
K
V
G
K
N
N
F
R
P
P
P
K
V
E
------------------------
S
S
V
V
R
I
E
P
K
N
P
P
P
P
I
N
F
Q
E
W
D
G
L
V
------------
R
I
T
F
--------------
V
R
K
-----
N
K
-----
T
L
S
A
------
A
F
K
S
S
A
V
Q
Q
L
---------
L
E
K
N
------
Y
R
I
H
C
S
V
-
H
-
N
I
I
I
P
-----------
E
D
F
---
S
--------
I
A
D
K
I
Q
-
Q
---
I
L
T
S
---------
T
G
F
S
D
K
R
A
R
S
M
D
I
D
-
D
F
I
R
L
L
H
---------
G
------
F
N
---
A
----------------
E
G
I
H
F
S
------------------------
24
HHSearch
41.11
16%
-56
- C4 -
1QYR
-
RSMA_ECOLI
A:
[18-78]
-------------------------------------------
N
F
L
------------------
N
--
D
Q
F
V
I
D
S
I
V
S
A
I
--
N
P
----------------
Q
K
G
----------
Q
A
M
V
-
E
---
I
G
P
G
L
A
A
------
L
T
E
P
V
G
E
R
--------------------------
L
D
------
Q
L
T
V
I
E
---
L
D
R
D
L
A
A
R
L
Q
--
T
H
P
----
F
---
L
--------
G
--
P
-
K
L
T
I
Y
Q
Q
D
A
---
M
T
F
N
---
F
G
E
L
A
E
K
M
G
Q
P
L
----------
R
V
F
------
G
N
L
P
Y
N
I
S
T
P
L
M
F
H
L
F
S
Y
T
D
A
I
A
D
M
H
F
M
L
-----------
Q
K
E
V
V
N
R
L
V
A
------------
G
P
N
S
K
------------------
A
Y
----------
G
R
----------
L
S
V
M
A
Q
Y
Y
C
N
V
-
I
P
V
L
E
V
P
P
--------
S
--
A
F
T
P
-
P
P
K
V
-
D
S
--
A
V
V
R
L
V
P
H
A
T
M
P
H
P
V
K
D
V
R
V
L
S
R
I
T
T
--
E
-
A
F
N
Q
R
R
K
T
I
R
N
S
L
G
N
L
F
S
V
E
V
L
T
G
M
G
I
D
P
A
M
R
A
E
N
I
S
V
A
------------
Q
Y
C
Q
M
A
N
----
Y
L
A
E
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
39.05
19%
-40
- C4 -
3UWP
3
DOT1L_HUMAN
A:
[151-214]
-----------------------------------------------------------------------
P
E
V
Y
G
E
T
S
--
F
D
-----
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
----------
D
L
F
V
-
D
---
L
G
S
G
V
G
Q
------
V
V
L
Q
V
A
A
A
T
N
------------------------
C
K
------
H
H
Y
G
V
E
---
K
A
D
I
P
A
K
Y
A
E
--
T
M
D
----
R
---
E
--------
F
--
R
-
K
W
M
K
W
Y
G
K
K
---
H
A
E
Y
---
T
L
E
R
G
D
F
L
S
E
E
W
----------
R
E
R
------
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
-----------
K
E
G
G
R
I
V
S
S
K
------------
P
F
A
P
L
------------------
N
F
----------
R
I
----------
N
S
R
N
L
S
D
I
G
T
I
-
M
R
V
V
E
L
S
P
--------
L
--
K
G
S
V
-
S
W
T
G
-
K
P
--
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
--
E
-
E
Q
E
A
A
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
38.94
12%
-33
- C4 -
1XDZ
-
RSMG_BACSU
A:
[69-111]
----------------------------------------------------------------------------------------------------
Q
V
----------
N
T
I
C
-
D
---
V
G
A
G
A
G
F
------
P
S
L
P
I
K
I
C
F
------------------
P
------
H
L
------
H
V
T
I
V
D
---
S
L
N
K
R
I
T
F
L
E
--
K
L
S
----
E
---
A
--------
L
--
Q
-
L
E
N
T
T
F
C
H
D
---
R
A
E
T
---
F
G
Q
R
K
D
V
R
E
S
Y
D
----------
I
V
T
------
A
R
A
V
A
R
L
S
V
L
S
E
L
C
L
P
L
V
K
K
N
G
L
F
V
A
L
K
A
-----------
A
A
E
E
E
L
N
A
G
K
------------
K
A
I
T
T
------------------
L
G
----------
G
E
----------
L
E
N
I
H
S
F
K
L
P
I
-
E
E
S
D
R
N
I
M
--------
V
--
I
R
K
I
-
K
N
T
P
-
K
K
--
Y
P
R
K
P
G
T
P
N
K
S
P
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
38.73
19%
-34
* C4 *
1ZQ9
1
DIM1_HUMAN
A:
[29-70]
-----------------------------------------------------------------------------------------------------
T
----------
D
V
V
L
-
E
---
V
G
P
G
T
G
N
------
M
T
V
K
L
L
E
K
--------------------------
A
K
------
K
V
V
A
C
E
---
L
D
P
R
L
V
A
E
L
H
--
K
R
V
----
Q
---
G
--------
T
--
P
-
V
A
S
K
L
Q
V
L
V
---
G
D
V
L
---
K
T
D
L
P
F
F
D
T
C
V
A
----------
N
L
P
------
Y
Q
I
S
S
P
F
V
F
K
L
L
L
H
R
P
F
F
R
C
A
I
L
M
F
Q
R
E
F
-----------
A
L
R
L
V
A
K
P
G
D
------------
K
L
Y
C
R
------------------
L
S
----------
I
N
----------
T
Q
L
L
A
R
V
D
H
L
M
-
K
V
G
K
N
N
F
R
--------
P
--
P
P
K
V
-
E
S
S
V
-
V
R
--
I
E
P
K
N
P
P
P
P
I
N
F
Q
E
W
D
G
L
V
R
I
T
F
V
R
K
--
N
-
K
T
L
S
A
A
F
K
S
S
A
V
Q
Q
L
L
E
K
N
Y
R
I
H
C
S
V
H
N
I
I
I
P
E
D
F
S
I
A
D
------------
K
I
Q
Q
I
L
T
----
S
T
G
F
S
D
K
R
A
R
-----
S
M
-----
D
I
D
D
------
F
I
R
L
L
H
G
F
N
A
---------
E
G
I
H
------
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
36.94
9%
-49
- C4 -
1JSX
-
RSMG_ECOLI
A:
[50-103]
------------------------------------------------------------------------------
L
--
V
R
-----
H
I
L
D
S
I
V
V
A
P
Y
L
Q
G
----------
E
R
F
I
-
D
---
V
G
T
G
P
G
L
------
P
G
I
P
L
S
I
V
R
------------------
P
------
E
A
------
H
F
T
L
L
D
---
S
L
G
K
R
V
R
F
L
R
--
Q
V
Q
----
H
---
E
--------
L
--
K
-
L
E
N
I
E
P
V
Q
S
---
R
V
E
E
---
F
P
S
E
P
P
F
D
G
V
I
S
----------
R
A
F
------
A
S
L
N
D
M
V
S
W
C
H
H
L
P
G
E
Q
G
R
F
Y
A
L
K
G
Q
M
P
E
-----------
D
E
I
A
L
L
P
E
E
Y
------------
Q
V
E
S
V
------------------
V
K
----------
L
Q
----------
V
P
D
G
E
R
H
L
V
V
I
-
K
A
N
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------