@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0667: (2015-12-03 )
MDNVRNFAIIAHIDHGKSTLADRLIEECNGLEAREMTNQVLDSMDIERERGITIKAQTVRLNYTANDGNRYCLNLMDTPGHVDFSYEVSRSLAACEGSLLVIDSSQGVEAQTLANVYKAIDNNHEIIVVLNKVDLPASDPERVKLQVEEIIGIGSSESILISAKTGLGIRDVLEAIITKLPAPQGNINAPLQAILVDSWYDPYLGVVILVRVKNGVLKKGMKIVMMSNNAVYQVDNIGIFTPKKVMTSELSAGEVGFITASMRKMADCKVGDTITEEKKPCGEALPGFKEIHPVVFCSIFPNKTDGFKYLREALEKLHLNDTSFTFEAETSNALGYGFRCGFLGMLHLEVIQERLEREFDLDLTATAPSVIYEVTTQSGETLNIHNPNDMPDSVKIKIVEEPWITATIMVPDQYLGEILSLCDERRGKQEDLSYVGNTMTALLKYKLPLSEVVLDFYDRLKSISKGYASLDWEISNYQESQIDKLSFLVNGEPVDALACIVHKSRSEKRGREICARLRDLIPRQQYKIAIQATVGGKIVARETINPYRKDVTAKLYGGDVTRKMKLLEKQKKGKKRLYSVGNVDIPHNAFIQALKIGD
Atome Classification :
(20 SA)
--------------.........10........20.......------.30...--.----------------.----------------...40........50........60....------------------....70........80........90........100.....-------.-------.110.......120..-.....130..------------------------------------------------------------.....-----------140---------.........150----------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------.-----------------------------------------------------------------------------.....160-------......--------------------------------------------------------------------------------------------------------------.-----------------..--------------------------170-----------------------...-------.....180.------------------..---------------------------.--------------------...190.......200.--..---.-..--------.--------------------------..210.......220.....------..---------230----------........-.240-.-.-....-..250.......260.---.--.....270.......-280.......-290....---..---..300.......310......---.320.....--.-.330.......340.......350.......-360...-----....370....---....380-----------------.---------------...-----------.---------------------------------------.-------..--------------------.390------------------.-------------------.---------------------------------------------------.-------.------------------.---------------....400-----.......---410---.........420.....-------------------------------..430.......440..-----------.....450.......-------460.......470.......480.......490.......500....-...510---------.......520.......530---........540.......550.......560.......570.......580.......590......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MDNV
R
N
F
A
I
I
A
H
IDHG
K
S
T
L
A
D
R
L
I
E
E
C------NGL
E
A
R
--
E
----------------
M
----------------
T
N
Q
V
L
D
SMDIERER
G
I
T
I
K
A
Q
T
V
R
L
N
Y
T
A------------------NDG
N
R
Y
C
L
N
LMDTPG
H
V
D
F
S
Y
E
V
S
R
S
L
A
ACE
G
S
L
L
V
I
DSSQG-------V-------
E
A
Q
T
L
A
N
V
Y
K
A
IDNNH-
E
I
I
V
V
L
NKVD------------------------------------------------------------LPAS
D
-----------
P
-----------
E
R
V
K
L
Q
V
E
E
I------------------------------------------------------------------------------------------I----------------------------------------------------------------------------------------------G--------------------------------------------------------------------------------------------------I------------------------------------------------------------------------------------G-----------------------------------------------------------------------------SS
E
S
I
L
---------
I
S
AKTG--------------------------------------------------------------------------------------------------------------L-----------------
G
I
--------------------------
R
D
------------------------
V
L
E
-------
A
I
I
T
KLPAP------------------QG---------------------------N--------------------INAP
L
Q
A
I
L
VDSWY--D--P
Y
---
L
-
G
V
--------
V
--------------------------
I
L
V
R
VKN
G
V
L
KKG
M
K
I
V
M
MS------NN---------
A
------------
V
Y
Q
VDN
I
G
-IFT--P-
K
-
K
V
M
T
-SELSAG
E
V
G
F
I
T
A
S
M
R
---
K
--
M
ADCKVGDTITEEKK-PCGEALP
G
F
K
-EI-
H
P
V
V
---
F
C
---
S
IFPNKT
D
G
F
K
Y
L
R
E
A
L
E
K
LH---LNDT
S
F
T
F
E--A-ETSNALGYG
F
R
C
G
F
L
G
M
L
H
L
E
V
I
Q
E
R
L
E
R
E
F-DLDLTA-----TAP
S
V
I
-
Y
E
V
T---TQSG
E
-------------------
T
---------------
L
NI-----------H---------------------------------------N-------PN--------------------DM--------------------P-------------------D---------------------------------------------------
S
-------
V
------------------
K
---------------
I
K
I
V
EEP-----W
I
T
A
T
I
M---V-----
P
D
Q
Y
L
G
E
I
L
S
L
C
D
ERRG-------------------------------
K
Q
E
D
L
S
Y
V
G
N
T
M
T
A
L
L
K
-----------YKL
P
L
S
E
V
V
L
D
F
Y
D
R
-------
L
K
S
I
S
K
G
Y
A
S
L
D
W
EISNY
Q
E
SQI
D
K
L
S
F
L
VNGE
P
V
D
A
L
A
C
I
V
HKSR
S
-
E
K
R
G
R
E
---------
I
C
A
R
L
R
D
LIPRQ
Q
Y
K
I
A
I
Q
----
A
TVG
G
K
I
V
A
RETIN
P
Y
R
K
D
V
T
A
K
LYGG
D
V
T
R
K
M
K
L
L
E
K
Q
K
KG
K
K
RLYSVGNVDIP
H
N
A
F
I
Q
A
L
KIGD
95
Fugue
94.37
53%
-121
- C1 -
3CB4
-
LEPA_ECOLI
A:
[1-555]
--------------
M
K
N
I
R
N
F
S
I
I
A
H
I
----
S
T
L
S
D
R
I
I
Q
I
C
------
G
G
------------------------------------------------------------
Q
S
V
T
L
D
Y
K
A
------------------
S
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
-------
V
-------
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
-
E
V
V
P
V
L
N
K
I
D
------------------------------------------------------------
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
E
D
I
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
A
V
R
---------
C
S
A
K
T
G
--------------------------------------------------------------------------------------------------------------
V
-----------------
G
V
--------------------------
Q
D
------------------------
V
L
E
-------
R
L
V
R
D
I
P
P
P
------------------
E
G
---------------------------
D
--------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
--
D
--
N
Y
---
L
-
G
V
--------
V
--------------------------
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
------
T
G
---------
Q
------------
T
Y
N
A
D
R
L
G
-
I
F
T
--
P
-
K
-
Q
V
D
R
-
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
---
D
--
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
A
E
K
A
L
P
G
F
K
-
K
V
-
K
P
Q
V
---
Y
A
---
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
E
--
P
-
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
-
D
L
D
L
I
T
-----
T
A
P
T
V
V
-
Y
E
V
E
---
T
T
S
R
E
-------------------
V
---------------
I
Y
V
-----------
D
---------------------------------------
S
-------
P
S
--------------------
K
L
--------------------
P
-------------------
A
---------------------------------------------------
V
-------
N
------------------
N
---------------
I
Y
E
L
R
E
P
-----
I
A
E
C
H
M
L
---
L
-----
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-------------------------------
V
Q
T
N
M
V
Y
H
G
N
--
Q
V
A
L
T
-----------
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
-------
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D
A
L
A
L
I
T
H
R
D
N
S
-
Q
N
R
G
R
E
---------
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
----
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
R
K
N
V
L
A
K
C
Y
G
-----------------------------------------
1
PsiBlast_PDB
88.39
54%
-108
* C1 *
3DEG
1
LEPA_ECOLI
C:
[1-542]
--------------
M
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
Q
I
C
------
G
G
L
S
D
R
--
E
----------------
M
----------------
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
K
A
Q
S
V
T
L
D
Y
K
A
------------------
S
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
-------
V
-------
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
-
E
V
V
P
V
L
N
K
I
D
------------------------------------------------------------
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
E
D
I
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
A
V
R
---------
C
S
A
K
T
G
--------------------------------------------------------------------------------------------------------------
V
-----------------
G
V
--------------------------
Q
D
------------------------
V
L
E
-------
R
L
V
R
D
I
P
P
P
------------------
E
G
---------------------------
D
--------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
--
D
--
N
Y
---
L
-
G
V
--------
V
--------------------------
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
------
T
G
---------
Q
------------
T
Y
N
A
D
R
L
G
-
I
F
T
--
P
-
K
-
Q
V
D
R
-
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
---
D
--
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
A
E
K
A
L
P
G
F
K
-
K
V
-
K
P
Q
V
---
Y
A
---
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
E
--
P
-
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
-
D
L
D
L
I
T
-----
T
A
P
T
V
V
-
Y
E
V
E
---
T
T
S
R
E
-------------------
V
---------------
I
Y
V
-----------
D
---------------------------------------
S
-------
P
S
--------------------
K
L
--------------------
P
-------------------
A
---------------------------------------------------
V
-------
N
------------------
N
---------------
I
Y
E
L
R
E
P
-----
I
A
E
C
H
M
L
---
L
-----
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-------------------------------
V
Q
T
N
M
V
Y
H
G
N
Q
V
A
--
L
T
-----------
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
-------
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D
A
L
A
L
I
T
H
R
D
N
S
-
Q
N
R
G
R
E
---------
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
----
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
---------------------------------------------------
67
HHSearch
73.58
27%
-94
- C1 -
2XEX
2
EFG_STAAU
A:
[8-679]
---------------
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
------
G
R
I
H
--------------------------------------------------------
T
S
A
A
T
T
A
A
W
E
-----------------------
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
-------
V
-------
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
-
P
R
I
V
F
V
N
K
M
D
------------------------------------------------------------
K
L
G
A
N
-----------
F
-----------
E
Y
S
V
S
T
L
H
D
R
------------------------------------------------------------------------------------------
L
QANAAPI
Q
L
P
I
G
AEDEFEAIIDLVEM
K
C
F
K
Y
TNDLGTE
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
--------------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------
F
Y
P
V
L
C
---------
G
T
A
F
K
N
--------------------------------------------------------------------------------------------------------------
K
-----------------
G
V
--------------------------
Q
L
------------------------
M
L
D
-------
A
V
I
D
Y
L
P
S
P
------------------
L
D
---------------------------
V
K
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
AD
D
S
A
E
F
A
A
L
A
F
K
V
M
T
--
D
--
P
Y
---
V
-
G
K
--------
L
--------------------------
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
------
K
G
---------
K
------------
R
E
R
V
G
R
L
L
-
Q
M
H
--
A
-
N
S
R
Q
E
I
-
D
T
V
Y
S
G
D
I
A
A
A
V
-
G
L
K
--------
D
T
G
T
G
D
T
L
C
G
E
K
N
-
D
--
I
I
L
E
S
M
E
-
F
P
-
E
P
V
I
---
H
L
---
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
---
E
E
D
P
T
F
H
A
H
--
T
--
T
G
Q
-----
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
-
N
V
E
C
N
V
-----
G
A
P
M
V
S
-
Y
R
E
T
---
F
K
S
S
A
Q
V
Q
G
K
F
S
R
QSGG
R
G
Q
Y
G
D
V
H
---------------
I
E
F
-----------
T
P
N
E
TGA
G
F
E
F
E
----------------------------
N
AIVGGVV
P
R
EY
I
P
S
V
E
A
G
L
K
D
A
M
E
N
GVLA
G
Y
--------------------
P
-------------------
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DVD-----------------------------------
S
-------
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
---------------
D
P
V
I
L
E
P
-----
M
M
K
V
T
I
E
---
M
-----
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
-------------------------------
R
V
D
G
M
E
P
R
G
-
N
-
A
Q
V
V
N
-----------
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
-------
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
E
---------------------------------------------------------------------------------------------------------------------
76
HHSearch
61.89
27%
-96
- C1 -
3VQT
1
RF3_DESVM
A:
[29-499]
---------------
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
------
G
A
I
Q
M
A
--
G
S
V
K
A
R---------------------------------------------
V
T
T
S
V
M
Q
F
P
Y
R
-----------------------
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
-------
V
-------
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
-
P
V
M
T
F
V
N
K
M
D
------------------------------------------------------------
R
E
A
L
H
-----------
P
-----------
L
D
V
M
A
D
I
E
Q
H
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------
I
E
C
A
P
M
T
W
P
I
G
MGSSFK
G
T
Y
D
LLHK
Q
L
H
L
F
SQ
S
G
I
V
I
H
G
ADDP
Q
L
D
E
Y
LGDQ
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
FD
E
E
R
Y
L
K
G-------
E
-----------------------------------------------------------------------------
L
T
P
V
F
F
---------
G
S
A
I
N
N
--------------------------------------------------------------------------------------------------------------
F
-----------------
G
V
--------------------------
R
E
------------------------
M
L
D
-------
M
F
V
E
F
A
P
G
P
------------------
Q
P
---------------------------
R
P
A
AT
R
V
V
E
P-----------
G
E
E
A
F
T
G
V
V
F
K
I
Q
A
--
N
----------
R
--------
M
--------------------------
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
------
T
G
---------
K
------------
D
V
T
V
A
N
A
T
-
I
F
M
--
A
-
Q
D
R
T
G
V
-
E
E
A
F
P
G
D
I
I
G
I
P
-------
N
--
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
-
V
--
L
K
F
V
G
I
P
-
N
F
-
A
P
E
H
---
F
R
---
R
V
R
L
K
N
P
L
K
A
K
Q
L
Q
K
G
L
E
Q
L
A
---
E
E
G
A
V
Q
L
F
R
P
-
L
-
V
N
N
D
-----
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y
-
G
V
D
A
V
Y
E
G
V
ST
H
T
A
R
W
V
-
Y
C
E
D
---
K
K
I
F
A
-------------------
D
---------------
F
Q
D
-----------
Y
---------------------------------------
H
-------
R
G
--------------------
E
L
--------------------
A
-------------------
V
---------------------------------------------------
D
-------
A
------------------
E
---------------
G
A
L
A
Y
L
A
-----
P
N
P
W
R
L
E
---
S
-----
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
60.96
25%
-74
- C1 -
2DY1
2
?
A:
[7-650]
---------------
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
------
G
A
K
E
R
R
--
G
R
VE-------------
E
----------------
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
-----------------------
G
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
-------
V
-------
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
-
P
R
M
V
V
V
T
K
L
D
------------------------------------------------------------
K
G
G
D
Y
-----------------------
Y
A
L
L
E
D
L
R
S
T
LGPILPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
----------------------------------------------------------------------------------------------
R
--------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------
L
-----------------------------------------------------------------------------
L
Y
P
V
A
L
---------
A
S
G
E
R
E
--------------------------------------------------------------------------------------------------------------
I
-----------------
G
V
--------------------------
L
P
------------------------
L
L
E
-------
L
I
L
E
A
L
P
S
P
------------------
T
E
R--------------------------
F
--------------------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
--
D
--
P
F
---
M
-
G
Q
--------
V
--------------------------
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
A
------
G
-----------------------
Q
V
R
L
P
H
L
Y
-
V
P
M
--
G
-
K
D
L
L
E
V
-
E
E
A
E
A
G
F
V
L
G
V
P
-------
K
--
A
E
G
L
H
R
G
M
V
L
W
Q
G
E
K
-
P
E
S
E
E
V
P
F
A
R
-
L
P
-
D
P
N
V
---
P
V
---
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
---
E
E
D
P
S
L
K
L
E
RQ
E
-
E
T
G
E
L
L
L
W
G
-----
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
-
G
V
E
V
E
F
-----
S
V
P
K
V
P
-
Y
R
E
T
---
I
K
K
V
A
E
G
Q
G
K
Y
K
K
Q
T
GG
H
G
Q
Y
G
D
V
W
---------------
L
R
L
-----------
E
P
A
S
E
Y
G
F
E
W
RITGGV------------------------
I
-------
P
S
--------------------
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
KKGVLAGF
P
VMG
F
K
A
I
VY
N
G
S
Y
H
EVDSS
D
---------------------------------------------------
L
-------
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
---
A
---------------
H
P
V
L
L
E
P
-----
I
Y
R
L
K
V
L
---
A
-----
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
-------------------------------
R
I
L
G
M
E
Q
E
G
-
A
-
L
S
V
V
H
-----------
A
E
V
P
L
A
E
V
-
L
E
Y
Y
K
A
-------
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
G
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.47
28%
-91
- C1 -
4ZCL
3
?
A:
[36-520]
--------------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
------
G
---------------------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
-------
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
------------------------------------------------------------
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
E
Q
L
DF
P
I
V
Y
A
SA
L
N
G
I
A
G
--------------------------------------------------------------------------------------------------------------
L
-----------------
D
H
--------------------------
E
D
------------------------
M
A
E
DM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------------------
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--
N
--
S
Y
---
V
-
G
V
--------
I
--------------------------
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
SE
G
K
T
R
N
A
---------
K
------------
V
G
K
V
--
L
G
-
H
L
G
--
L
-
E
-
R
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
G
---------
L
G
E
L
N
I
S
D
T
V
C
D
T
Q
N
-
V
--
E
A
L
P
A
L
S
-
V
D
-
E
P
T
V
S
M
F
F
C
V
NT
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
----
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------
G
-------
R
------------------
K
-------------------
Q
E
P
-----
Y
E
N
V
T
L
D
---
V
-----
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-------------------------------
D
L
K
N
M
N
P
D
G
K
G
R
V
R
-
L
D
-----------
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
-------
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
-
F
G
L
Q
D
R
---------
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
----
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
--------
3
PsiBlast_PDB
58.29
28%
-91
- C1 -
4ZCI
2
?
A:
[36-520]
--------------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
------
G
---------------------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
-------
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
------------------------------------------------------------
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
E
Q
L
DF
P
I
V
Y
A
S
A
L
N
G
I
A
G
--------------------------------------------------------------------------------------------------------------
L
-----------------
D
H
--------------------------
E
D
------------------------
M
A
E
DM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------------------
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--
N
--
S
Y
---
V
-
G
V
--------
I
--------------------------
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
SEG
K
T
R
N
A
---------
K
------------
V
G
K
V
--
L
G
-
H
L
G
--
L
-
E
-
R
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
G
---------
L
G
E
L
N
I
S
D
T
V
C
D
T
Q
N
-
V
--
E
A
L
P
A
L
S
-
V
D
-
E
P
T
V
S
M
F
F
C
V
NT
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
----
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------
G
-------
R
------------------
K
-------------------
Q
E
P
-----
Y
E
N
V
T
L
D
---
V
-----
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-------------------------------
D
L
K
N
M
N
P
D
G
K
G
R
V
R
-
L
D
-----------
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
-------
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
-
F
G
L
Q
D
R
---------
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
----
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
--------
2
PsiBlast_PDB
57.80
28%
-89
- C1 -
4ZCM
4
?
A:
[36-520]
--------------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
------
G
---------------------------------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
-------
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
------------------------------------------------------------
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
D
L
F-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
E
Q
L
DF
P
I
V
Y
A
SA
L
N
G
I
A
G
--------------------------------------------------------------------------------------------------------------
L
-----------------
D
H
--------------------------
E
D
------------------------
M
A
E
DM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------------------
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--
N
--
S
Y
---
V
-
G
V
--------
I
--------------------------
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
SE
G
K
T
R
N
A
---------
K
------------
V
G
K
V
--
L
G
-
H
L
G
--
L
-
E
-
R
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
G
---------
L
G
E
L
N
I
S
D
T
V
C
D
T
Q
N
-
V
--
E
A
L
P
A
L
S
-
V
D
-
E
P
T
V
S
M
F
F
C
V
NT
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
----
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------
G
-------
R
------------------
K
-------------------
Q
E
P
-----
Y
E
N
V
T
L
D
---
V
-----
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-------------------------------
D
L
K
N
M
N
P
D
G
K
G
R
V
R
-
L
D
-----------
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
-------
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
-
F
G
L
Q
D
R
---------
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
----
H
S
R
S
N
D
L
T
V
N
C
L
T
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
--------
75
HHSearch
57.60
24%
-94
- C1 -
2H5E
1
RF3_ECOLI
A:
[11-477]
---------------
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
------
Q
----------------------------------------------------------
I
T
T
S
V
M
Q
F
P
Y
H
-----------------------
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
-------
V
-------
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
T
-
P
I
L
T
F
M
N
K
L
D
------------------------------------------------------------
R
D
I
R
D
-----------
P
-----------
M
E
L
L
D
E
V
E
N
E
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
K
I
G
C
A
P
I
T
W
P
I
G
CGKLFK
G
V
Y
H
LYKD
E
T
Y
L
Y
Q
S
GKGHTIQE
V
R
I
V
K
G
LNN
P
D
L
D
A
A
VG
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
G
ASNEFD
K
E
L
F
L
A
-------------
G
------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------
I
T
P
V
F
F
---------
G
T
A
L
G
N
--------------------------------------------------------------------------------------------------------------
F
-----------------
G
V
--------------------------
D
H
------------------------
M
L
D
-------
G
L
V
E
W
A
P
A
P
------------------
M
P
---------------------------
R
Q
T
DT
R
T
V
E
A-----------
S
E
D
K
F
T
G
F
V
F
K
I
Q
A
N
M
D
P-
K
H
---
R
-
D
R
--------
V
--------------------------
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
------
T
A
---------
K
------------
D
V
V
I
S
D
A
L
-
T
F
M
--
A
------
V
-
E
E
A
Y
P
G
D
I
L
G
L
H
-------
N
--
H
G
T
I
Q
I
G
D
T
F
T
Q
G
E
M
----
M
K
F
T
G
I
P
-
N
F
-
A
P
E
L
---
F
R
---
R
I
R
L
K
D
P
---
K
Q
L
L
K
G
L
V
Q
L
S
---
E
E
G
A
V
Q
V
F
R
P
-
I
-
S
N
N
D
L
I
-----
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y
-
N
V
E
A
V
Y
-----
E
S
V
N
V
A
-
T
A
R
W
---
V
E
C
A
D
-------------------
A
---------------
K
K
F
-----------
E
---------------------------------------
E
-------
F
K
--------------------
R
K
--------------------
N
-------------------
E
---------------------------------------------------
S
-------
Q
------------------
L
---------------
A
L
D
G
G
D
N
-----
L
A
Y
I
A
T
S
---
M
-----
V
N
L
R
L
A
Q
E
R
Y
P
D
V
Q
F
H
Q
-------------------------------
T
R
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
56.97
22%
-83
- C1 -
3JB9
-
?
B:
[139-930]
---------------
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
Y
Y
T
------
H
P
D
T
K
P
PK
R
----------------
R
----------------
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
K
S
T
P
L
T
L
A
V
S
D
------------------
M
K
G
K
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
-------
V
-------
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
M
-
P
I
V
L
V
L
N
K
V
D
------------------------------------------------------------
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
-----------
R
H
V
I
D
E
V
N
D
N
------------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------
C
Q
I
SKDLK
Y
R
-----------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------
S
PE---------------------------------------------------------------------------
L
G
N
V
C
F
---------
A
S
C
D
L
G
Y
C
F
T
L
S
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
LWGD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
F
QIYLK
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
S
F
FG
F
-----------------
P
V
---------------------------
G
------------------------
F
V
N
-------
A
V
T
R
H
I
P
S
P
------------------
R
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
--------------------
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
--
T
--
V
D
---
A
N
N
F
--------
Y
--------------------------
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
K
V
L
G
------
E
N
---------
Y
SLEDEED
M
V
---
V
A
H
I
A
E
I
C
-
V
P
C
--
A
-
R
Y
R
L
H
V
-
D
G
A
V
A
G
M
L
V
L
L
G
-
G
V
D
---
N
----
S
I
S
K
T
A
T
I
V
S
D
N
L
K
D
D
P
Y
I
F
R
P
I
A
H
M
S
-
E
S
V
F
---
K
V
---
A
V
E
P
H
N
P
S
E
L
P
K
L
L
D
G
L
R
K
T
N
---
K
S
Y
P
L
S
I
T
K
V
-
E
-
E
S
G
E
H
T
I
F
G
-----
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
Y
S
E
I
E
I
R
V
-----
S
D
P
V
A
R
-
F
C
E
T
---
A
V
D
T
S
-------------------
S
I
K
C
F
S
D
T
PNKK
N
R
I
T
M
V
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDR
G
-------
T
N
--------------------
I
L
--------------------
R
-------------------
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
Q
G
F
Q
W
G
T
REGPLCD
E
T
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRGGG
Q
------------------
I
I
P
T
A
R
R
V
C
Y
S
S
F
L
T
A
S
P
R
L
M
E
P
-----
V
Y
M
V
E
V
H
---
A
-----
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
-------------------------------
H
V
L
Q
D
I
P
R
P
G
S
P
L
Y
L
V
R
-----------
A
L
I
P
V
I
D
S
-
C
G
F
E
T
D
-------
L
R
V
H
T
Q
G
Q
A
M
C
Q
M
V
F
D
H
W
Q
V
---------
V
P
G
D
P
L
D
K
S
I
K
P
K
P
L
E
P
A
-
R
G
S
D
L
A
---------
R
D
F
L
I
K
T
R
R
R
K
G
L
V
E
D
V
S
T
----
T
R
Y
F
D
Q
E
M
-----------------------------------------------------------
74
HHSearch
54.50
24%
-81
- C1 -
3TR5
2
RF3_COXBU
A:
[11-513]
---------------
A
M
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
------
G
A
I
Q
L
A
--
G
T
I
K
S
R-----------------------------
H
A
T
S
D
W
M
E
L
E
K
Q
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
K
-----------------------
D
Y
L
I
N
L
L
D
T
P
G
H
A
D
F
T
E
D
T
Y
R
T
L
T
A
V
D
S
A
L
M
V
I
D
A
A
K
G
-------
V
-------
E
P
R
T
I
K
L
M
E
V
C
R
L
R
H
T
-
P
I
M
T
F
I
N
K
M
D
------------------------------------------------------------
R
D
T
R
P
-----------
S
-----------
I
E
L
L
D
E
I
E
S
I
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
R
--------------------------------------------------------------------------------------------------
I
H
C
A
P
V
T
W
P
I
G
MGKYFK
G
I
Y
H
LIED
A
I
Y
L
Y
Q
P
GKHERVGE
S
E
R
I
E
G
INN
P
E
L
D
K
K
L
G
D
L
A
S
E
L
R
N
E
I
E
L
V
K
G
ASHPFE
R
E
G
Y
L
K
G
E
-----------------------------------------------------------------------------
L
T
P
I
F
F
---------
G
S
A
I
N
N
--------------------------------------------------------------------------------------------------------------
F
-----------------
G
V
--------------------------
G
E
------------------------
L
L
D
-------
A
F
V
K
E
A
P
P
P
------------------
Q
G
---------------------------
R
E
T
N
S
R
L
V
K
P-----------
E
E
E
K
F
S
G
F
V
F
K
I
Q
A
--
N
MD
G
H
---
R
-
D
R
--------
I
--------------------------
A
F
L
R
I
A
S
G
Q
Y
Q
K
G
M
K
A
Y
H
V
R
------
L
K
---------
K
------------
E
I
Q
I
N
N
A
L
-
T
F
M
--
A
G
K
-
R
E
N
A
-
E
E
A
W
P
G
D
I
I
G
L
H
-------
N
--
H
G
T
I
Q
I
G
D
T
F
T
Q
G
E
R
----
F
K
F
T
G
I
P
-
N
F
-
A
S
E
L
---
F
R
---
L
V
R
L
K
D
P
L
K
Q
K
A
L
L
K
G
L
T
Q
L
S
---
E
E
G
A
T
Q
L
F
R
--
P
L
D
S
N
E
-----
L
I
L
G
A
V
G
L
L
Q
F
D
V
V
A
Y
R
L
E
N
E
Y
-
N
V
K
C
V
Y
-----
E
S
V
N
V
V
T
A
R
W
V
---
I
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
D
----
K
A
V
L
E
R
F
N
Q
E
---------------------------------
Q
S
R
N
L
A
Y
D
G
---
G
G
H
L
T
-----------
Y
L
A
P
S
R
V
N
-
L
E
I
T
M
E
-------
K
W
P
E
I
Q
F
S
E
T
R
E
H
--------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.45
28%
-78
- C1 -
5A9X
1
?
A:
[2-486]
--------------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
------
G
----------------------------------------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
---------------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
-------
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
------------------------------------------------------------
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
D
L
F
-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
E
Q
L
DFPI
V
Y
A
S
A
L
N
---
G
--------------------------------------------------------------------------------------------------------------
L
-----------------
D
H
--------------------------
E
D
------------------------
M
A
E
D
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------------------
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--
N
--
S
Y
---
V
-
G
V
--------
I
--------------------------
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
SEGK
T
R
N
A
---------
K
------------
V
G
K
V
--
L
G
-
H
L
G
--
L
-
E
-
R
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
------------
E
L
N
I
S
D
T
V
C
D
T
Q
N
-
V
--
E
A
L
P
A
L
S
-
V
D
-
E
P
T
V
S
M
F
F
C
V
NT
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
----
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------
G
-------
R
------------------
K
-------------------
Q
E
P
-----
Y
E
N
V
T
L
D
---
V
-----
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-------------------------------
D
L
K
N
M
N
P
D
G
K
G
R
V
R
-
L
D
-----------
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
-------
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
-
F
G
L
Q
D
R
---------
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
----
H
S
R
S
N
D
L
T
V
N
C
L
T
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
--------
5
PsiBlast_PDB
48.95
28%
-75
- C1 -
5A9W
1
?
A:
[2-486]
--------------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
------
G
T
-------------------------------------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
--------------------------
N
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
-------
P
-------
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
-
K
P
I
V
V
I
N
K
V
D
------------------------------------------------------------
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
F
D
L
F
-----------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
A
T
D
E
Q
L
DFPI
V
Y
A
S
A
L
N
---
G
--------------------------------------------------------------------------------------------------------------
L
-----------------
D
H
--------------------------
E
D
------------------------
M
A
E
D
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------------------
D
V
---------------------------
D
--------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--
N
--
S
Y
---
V
-
G
V
--------
I
--------------------------
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
K
T
R
N
A
---------
K
------------
V
G
K
V
--
L
G
-
H
L
G
--
L
-
E
-
R
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
------------
E
L
N
I
S
D
T
V
C
D
T
Q
N
-
V
--
E
A
L
P
A
L
S
-
V
D
-
E
P
T
V
S
M
F
F
C
V
NT
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
----
E
T
E
D
A
--
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
I
-
F
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------
G
-------
R
------------------
K
-------------------
Q
E
P
-----
Y
E
N
V
T
L
D
---
V
-----
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-------------------------------
D
L
K
N
M
N
P
D
G
K
G
R
V
R
-
L
D
-----------
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
-------
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
-
F
G
L
Q
D
R
---------
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
----
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
97
Fugue
48.82
25%
-65
- C1 -
4M1K
2
?
A:
[6-688]
-----------EYD
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
------
G
R
I
A
A
---------------------------------------------------------------
V
T
T
------------------
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
-------
V
-------
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
-
P
R
I
A
F
A
N
K
M
D
KTGAD
L
W
L
V
I
R
T
M
Q
E
RLGARPVVM
Q
L
P
I
G
REDTFS
G
I
I
D
VLRM
K
A
Y
T
Y
GNDLGTDIREIP
I
P
E
E
Y
-----------
L
-----------
D
Q
A
R
E
Y
H
E
K
L
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
------------------------------------------------------------
T
E
E
E
L
V
---------
A
A
I
R
K
G
--------------------------------------------------------------------------------------------------------------
T
I
D
LK
I
T
P
V
F
L
G
S
ALKNK
G
V
--------------------------
Q
L
------------------------
L
L
D
-------
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
K
G
T
T
PEG
E
V
V
E
I
H
P
---------------------------
D
--------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--
D
--
P
Y
---
V
-
G
R
--------
L
--------------------------
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
------
K
G
---------
R
------------
K
E
R
V
A
R
L
L
-
R
M
H
--
A
-
N
-
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
-------
G
--
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
-
P
R
-
V
I
L
E
S
I
E
-
V
P
-
E
P
V
I
---
D
V
---
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
F
R
V
S
TH
P
-
E
T
G
Q
T
I
I
S
G
-----
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
K
V
D
A
N
V
-----
G
K
P
Q
V
A
-
Y
R
E
T
I
T
K
P
V
D
V
E
-------------------
G
---------------
K
F
I
-----------
R
---------------------------------------
L
-------
T
G
--------------------
G
R
--------------------
G
-------------------
Q
---------------------------------------------------
Y
-------
G
------------------
H
---------------
V
K
I
K
V
E
P
---------------
L
-----
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
V
I
-------------------------------
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
SGPL-------
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
----------
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
--
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
---------
V
I
G
D
L
N
A
---
R
R
G
Q
I
L
G
M
E
P
R
GN
A
Q
V
I
R
A
F
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
--------------
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
----
77
HHSearch
48.76
29%
-98
- C1 -
1JNY
1
EF1A_SULSO
A:
[4-317]
---------------
K
P
H
L
N
L
I
V
I
G
H
V
D
H
G
K
S
T
L
V
G
R
L
L
M
D
R
------
G
F
I
D
E
K
--
T
V
K
E
A
E
E
A
A
K
K
L
GKES
E
K
----------------
F
A
F
L
L
D
R
L
K
E
E
-----------
M
R
F
E
T
-----------------------
K
K
Y
F
F
T
I
I
D
A
P
G
H
R
D
F
V
K
N
M
I
T
G
A
S
Q
A
D
A
A
I
L
V
V
S
A
K
K
G
E
Y
E
A
G
M
S
V
-------
E
G
Q
T
R
E
H
I
I
L
A
K
T
M
G
L
D
Q
L
I
V
A
V
N
K
M
D
------------------------------------------------------------
L
T
E
P
P
YD
E
K
R
------
Y
-----------
K
E
I
V
D
Q
V
S
K
F
M
R
S
---------------------------------------------------------------------------------------
Y
----------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
F
NT----------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------
K
V
R
F
V
P
---------
V
V
A
P
S
G
--------------------------------------------------------------------------------------------------------------
D
-----------------
N
I
--------------------------
T
H
KSENMKWYNGP-------------
T
L
E
-------
E
Y
L
D
Q
L
E
L
P
------------------
P
K
---------------------------
P
--------------------
V
D
K
P
L
R
I
P
I
Q
D
V
Y
S
--
I
--
S
G
---
V
-
G
T
--------
V
--------------------------
P
V
G
R
V
E
S
G
V
L
K
V
G
D
K
I
V
F
M
P
------
A
G
---------
K
------------
V
G
E
V
R
S
I
E
-
T
H
H
-------
T
K
M
-
D
K
A
E
P
G
D
N
I
G
F
N
V
R
G
V
---
E
--
K
K
D
I
K
R
G
D
V
V
G
H
P
N
N
-
P
P
T
V
A
D
E
F
T
A
-
R
I
-
I
V
V
W
---
H
P
---
T
A
L
A
N
G
Y
T
P
V
L
H
V
H
T
A
S
V
A
C
R
---
V
S
E
L
V
S
K
L
D
--
P
-
R
T
G
Q
E
A
E
K
N
P
Q
F
L
K
Q
G
D
V
A
I
V
K
F
K
P
I
K
P
L
C
V
-
E
K
Y
N
E
F
-----
P
P
L
G
R
F
-
A
M
R
D
---
M
G
K
T
V
-------------------
G
---------------
V
G
I
-----------
I
---------------------------------------
V
-------
D
V
--------------------
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
47.68
24%
-60
- C1 -
1ELO
-
?
?:
[5-689]
----------VEYD
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
------
G
R
I
A
V
----------------------------------------------------------------
T
T
------------------
C
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
-------
V
-------
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
-
P
R
I
A
F
A
N
K
M
D
------------------------------------------------------------
K
T
G
A
D
-----------
L
-----------
W
L
V
I
R
T
M
Q
E
R
------------------------------------------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------
R
P
V
V
M
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
YGNDLGT
D
I
R
E
I
PIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
---------
A
A
I
R
K
G
--------------------------------------------------------------------------------------------------------------
T
I
D
LK
I
T
P
V
F
L
G
S
ALKNK
G
V
--------------------------
Q
L
------------------------
L
L
D
-------
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
---------------------------
D
--------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--
D
--
P
Y
---
V
-
G
R
--------
L
--------------------------
T
F
I
R
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Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
------
K
G
---------
R
------------
K
E
R
V
A
R
L
L
R
M
H
A
--
N
-
H
-
R
E
E
V
-
E
E
L
K
A
G
D
L
G
A
V
V
-------
G
--
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
-
P
--------------------------
R
V
I
L
I
D
V
A
I
E
P
K
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
F
R
V
S
--
T
-
H
P
Q
T
I
I
S
G
------
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-
V
G
K
P
Q
V
-----
A
Y
R
E
T
I
-
T
K
P
V
---
D
V
E
G
K
-------------------
F
---------------
I
R
Q
-----------
T
---------------------------------------
G
-------
G
R
--------------------
G
Q
--------------------
Y
-------------------
G
---------------------------------------------------
H
-------
V
------------------
K
---------------
I
K
V
E
P
L
P
RGS
G
F
E
F
V
N
A
I
V
GGV
I
-----
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
-------------------------------
S
-----------
G
P
L
I
G
-----------
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
-------
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
--
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
-
G
D
V
I
G
D
---------
L
N
A
R
-
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
----
V
I
R
A
F
--
V
P
L
A
E
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
--------------
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
---
83
HHSearch
47.44
26%
-93
- C1 -
1F60
-
EF1A_YEAST
A:
[5-328]
---------------
K
S
H
I
N
V
V
V
I
G
H
V
D
S
G
K
S
T
T
T
G
H
L
I
Y
K
C
------
G
G
I
D
K
R
--
T
----------------
I
E
K
F
E
K
E
A
AELGK
G
S
F
K
Y
A
W
V
L
D
K
L
K
A
E
R
E
R
G
I
T
I
D
I
A
L
W
K
F
E
T
P
-----------------------
K
Y
Q
V
T
V
I
D
A
P
G
H
R
D
F
I
K
N
M
I
T
G
T
S
Q
A
D
C
A
I
L
I
I
A
G
G
V
G
-------
E
F
E
A
G
I
SK
D
G
Q
T
R
E
H
A
L
L
A
F
T
L
G
V
R
Q
L
I
V
A
V
N
K
M
D
------------------------------------------------------------
S
V
K
W
D
E
S
R
--------
F
-----------
Q
E
I
V
K
E
T
S
N
F
------------------------------------------------------------------------------------------
I
K
K
V
-------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
Y
NP----------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------
T
V
P
F
V
P
---------
I
S
G
W
N
G
--------------------------------------------------------------------------------------------------------------
D
-----------------
N
M
--------------------------
I
E
ATTNAPWYK
G
W
E
K
E
T
KA
G
V
V
K
G
K
T
L
L
E
-------
A
I
-
D
A
I
E
Q
P
------------------
S
R
---------------------------
P
--------------------
T
D
K
P
L
R
L
P
L
Q
D
V
Y
K
--
I
--
G
G
---
I
-
G
T
--------
V
--------------------------
P
V
G
R
V
E
T
G
V
I
K
P
G
M
V
V
T
F
A
P
------
A
G
---------
V
------------
T
T
E
V
K
S
V
E
-
M
H
H
-------
E
Q
L
-
E
Q
G
V
P
G
D
N
V
G
F
N
V
K
N
V
---
S
--
V
K
E
I
R
R
G
N
V
C
G
D
A
K
N
-
D
P
P
K
G
C
A
S
F
N
-
A
T
-
V
I
V
L
---
N
H
---
P
G
Q
I
S
A
G
Y
S
P
V
L
D
C
H
T
A
H
I
A
C
---
R
F
D
E
L
L
E
K
N
--
D
-
R
R
S
G
K
K
L
E
D
H
P
K
F
L
K
S
G
D
A
A
L
V
K
F
V
P
S
K
P
M
C
-
V
E
A
F
S
E
-----
Y
P
P
L
G
R
-
F
A
V
R
---
D
M
R
Q
T
-------------------
V
---------------
A
V
G
-----------
V
---------------------------------------
I
-------
K
S
--------------------
V
D
--------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
45.82
22%
-94
- C1 -
3P26
-
HBS1_YEAST
A:
[166-496]
----------------
P
H
L
S
F
V
V
L
G
H
V
D
A
G
K
S
T
L
M
G
R
L
L
Y
D
L
------
N
I
V
N
Q
S
--
Q
L
R
K
L
QR----------------------------------------
R
G
V
T
V
S
I
C
T
S
H
F
S
T
-----------------------
H
R
A
N
F
T
I
V
D
A
P
G
H
R
D
F
V
P
N
A
I
M
G
I
S
Q
A
D
M
A
I
L
C
V
D
C
S
T
-FD-----
L
-------
D
G
Q
T
K
E
H
M
L
L
A
S
S
L
G
I
H
N
L
I
I
A
M
N
K
M
D
------------------------------------------------------------
N
V
D
W
S
-----------
Q
Q
R
F
--------
E
E
I
K
S
K
L
L
P
Y
L
V
D
---------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------
F
FE----------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
N
I
N
W
V
P
---------
I
S
G
F
S
G
--------------------------------------------------------------------------------------------------------------
E
-----------------
G
V
YK
I
E
Y
T
D
E
V
R
Q
W
YNG-----------
P
N
------------------------
L
M
S
-------
T
L
E
N
A
A
F
K
I
S
K
E
N
E
-------------
G
I
---------------------------
N
--------------------
K
D
D
P
F
L
F
S
V
L
E
I
I
P
-------TSN
D
-
L
A
--------
L
--------------------------
V
S
G
K
L
E
S
G
S
I
Q
P
G
E
S
L
T
I
Y
P
------
S
E
---------
Q
------------
S
C
I
V
D
K
I
Q
-
V
G
S
QQ----
H
E
E
T
-
D
V
A
I
K
G
D
F
V
T
L
K
--
L
R
---
K
AY
P
E
D
I
Q
N
G
D
L
A
A
S
V
D
Y
-
S
S
I
H
S
A
Q
C
F
V
-
L
E
-
L
T
T
F
---
D
M
---
N
R
P
L
L
P
G
T
P
F
I
L
F
I
G
V
K
E
Q
P
A
---
R
I
K
R
L
I
S
F
I
--
D
-
K
G
N
T
A
S
K
K
K
I
R
H
L
G
S
K
Q
R
A
F
V
E
I
E
L
I
E
V
K
R
W
-
I
P
L
L
T
A
-----
H
E
N
D
R
L
-
G
R
V
V
---
L
R
K
D
G
-------------------
R
---------------
T
I
A
-----------
A
---------------------------------------
G
-------
K
I
--------------------
S
E
--------------------
I
-------------------
T
---------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Fugue
45.78
21%
-69
- C1 -
1N0V
-
EF2_YEAST
C:
[2-842]
VAFTVDQMRSLMDK
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
GIISAA
K
G
I
T
I
K
--
S
----------------
T
----------------
A
I
S
L
Y
S
E
M
S
D
E
D
V
K
E
I
K
Q
K
T
D
----------------------------
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
-------
V
-------
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
-
K
P
V
V
V
I
N
K
V
D
------------------------------------------------------------
R
A
L
L
E
-----------
L
QVSKEDLYQTF
A
R
T
V
E
S
V
N
V
I
------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------
S
TYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAI
M
------------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------
F
K
K
D
E
I
---------
P
V
L
L
E
K
--------------------------------------------------------------------------------------------------------------
L
-----------------
E
I
VLKGDEKDLEGKALLKVVMRKFLPAA
D
A
------------------------
L
L
E
-------
M
I
V
L
H
L
P
S
P
------------------
V
T
---------------------------
A
--------------------
Q
A
Y
R
A
E
Q
L
Y
E
G
P
A
D
--
D
--
A
N
---
C
-
I
A
--------
I
KNCDPKADLMLYVSKMVPTSDKGRFY
A
F
G
R
V
F
A
G
T
V
K
S
G
Q
K
V
R
I
Q
G
------
P
N
YVPGKKDDL
F
------------
I
K
A
I
Q
R
V
V
-
L
M
M
--
G
-
R
-
F
V
E
P
I
D
D
C
P
A
G
N
I
I
G
L
V
G
I
D
Q
---
F
--
L
L
K
---
T
G
T
L
T
T
S
E
T
-
A
--
H
N
M
K
V
M
K
-
F
S
V
S
P
V
V
---
Q
V
---
A
V
E
V
K
N
A
N
D
L
P
K
L
V
E
G
L
K
R
L
S
---
K
S
D
P
C
V
L
T
Y
--
M
-
S
E
S
---
G
E
H
I
V
A
G
-
T
G
E
L
H
L
E
I
C
L
Q
D
L
E
H
D
H
A
G
V
P
L
K
I
-----
S
P
P
V
V
A
-
Y
R
E
T
VE-
S
E
S
S
Q
-------------------
T
---------------
A
L
S
-----------
K
---------------------------------------
S
-------
P
N
--------------------
K
---------------------
H
-------------------
N
---------------------------------------------------
R
-------
I
------------------
Y
---------------
L
K
A
E
P
I
D
-----
E
E
V
S
L
A
I
---
E
NGIIN
P
R
D
D
F
K
A
R
A
R
I
M
A
D
D
Y
G
WDVTDARKIWCFGPDGNGPNLVIDQTKAVQY
L
H
E
I
K
D
S
V
V
A
A
F
Q
W
A
T
K
EGPIFGEEMRS
V
R
V
N
I
L
D
V
T
L
H
A
D
A
I
HRGGGQI
I
P
T
M
R
R
A
T
Y
A
G
F
L
L
A
D
P
K
I
Q
E
P
V
F
L
V
E
I
Q
C
P
E
Q
A
V
G
G
I
Y
S
V
L
N
K
K
R
G
-
Q
V
V
S
E
E
QRPGTPLFT
V
K
A
Y
L
P
-
V
N
E
S
F
G
F
T
G
E
L
R
----
Q
A
T
G
G
Q
A
F
P
Q
M
V
F
D
H
W
S
T
L
G
S
D
P
L
D
P
T
S
K
A
G
E
I
V
L
A
A
R
K
R
H
G
M
K
E
E
V
P
------
G
W
Q
E
Y
Y
D
K
L
----
89
HHSearch
45.29
21%
-89
- C1 -
1S0U
1
IF2G_METJA
A:
[7-314]
----------------
A
E
V
N
I
G
M
V
G
H
V
D
H
G
K
T
S
L
T
K
A
L
T
G
V
W
----------------------------------------------------
T
D
-------
R
G
I
S
I
R
L
G
Y
A
D
C
E
I
R
K
C
PQCGTYTTKPRCPNCL
A
E
T
E
F
L
R
R
V
S
F
V
D
S
P
G
H
E
T
L
M
A
T
M
L
S
G
A
S
L
M
D
G
A
I
L
V
I
A
A
N
E
P
C------
P
-------
Q
P
Q
T
K
E
H
L
M
A
L
E
I
L
G
I
D
K
I
I
I
V
Q
N
K
I
D
------------------------------------------------------------
L
V
D
E
K
Q
----------
A
-----------
E
E
N
Y
E
Q
I
K
E
F
------------------------------------------------------------------------------------------
V
KGT-------------------------------------------------------------------------------------------
I
--------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------
N
A
P
I
I
P
---------
I
-------------------------------------------------------------------------------------------------------------------------------------
N
I
--------------------------
D
V
------------------------
L
L
K
-------
A
I
Q
D
F
I
P
T
P
------------------
K
R
---------------------------
D
--------------------
P
D
A
T
P
R
M
Y
V
A
R
S
F
D
--
I
--
N
K
---
P
-
G
T
EIKDLKGG
V
--------------------------
L
G
G
A
I
I
Q
G
V
F
K
V
G
D
E
I
E
I
R
P
------
G
I
---------
K
V
T
E
GNKT
F
W
K
P
L
T
T
K
I
V
S
L
A
-
A
G
N
-------
T
I
L
-
R
K
A
H
P
G
G
L
I
G
V
G
T
T
L
D
PYL
T
--
K
S
D
A
L
T
G
S
V
V
G
L
P
G
T
-
L
P
P
I
R
E
K
I
T
I
-
R
A
-
N
L
L
D
---
R
V
---
V
G
T
K
E
E
L
K
I
E
P
L
R
T
G
E
V
L
M
L
N
---
I
G
T
A
T
T
A
G
V
--
I
-
T
S
A
R
G
D
I
A
D
I
K
L
K
L
P
I
C
A
E
I
G
D
R
V
A
I
S
R
R
V
G
-
S
R
W
R
L
I
-----
G
Y
G
T
I
E
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------