@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0299: (2016-03-14 )
MSDSEKEILKRIKDNPFISQRELAEAIGLSRPSVANIISGLIQKEYVMGKAYVLNEDYPIVCIGAANVDRKFYVHKDLVAETSNPVTSTRSIGGVARNIAENLGRLGETVAFLSASGQDSEWEMIKRLSTPFMNLDHVQQFENASTGSYTALISKEGDMTYGLADMEVFDYITPEFLIKRSHLLKKAKCIIVDLNLGKEALNFLCAYTTKHQIKLVITTVSSPKMKNMPDSLHAIDWIITNKDETETYLNLKI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70....-....80------------------.--------------------.---------------------.-.-.-.-.-..90........100....-----.----.---.110.......120....-...-------130.-.......140........150..-.....160.....-.-.170...---....--180-........190....-----.-----..200.......210-------........220..--------.--------....230..-.....240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSD
S
E
K
E
I
L
K
R
IKDNPFI
S
Q
R
E
L
A
E
A
IGLSR
P
S
V
A
N
I
I
S
G
L
I
Q
K
E
Y
VMG
K
A
Y
V
LNEDY
P
I
V
C
I
GAANVD
R
K
F
Y
V
H
-
K
D
L
VA-------------------E--------------------T---------------------S-N-P-V-T-S
T
R
S
I
G
G
V
A
R
N
I
A
E
N
L
G
R
L
-----
G
----
E
---
T
V
A
F
L
SASGQ
D
S
E
W
E
M
I
K
-
R
LS-------T-PF-M
N
L
D
H
V
Q
Q
F
-ENASTG
S
Y
T
A
L
I
S-KEG
D
M
T
YGL
A
D
M
E
-
V
-
F
D
YI
T
P
E
---
F
L
I
K
--
R
S
--
H
L
LKKA
K
C
I
I
V
DLNL-----
G
-----
K
E
A
L
N
F
L
C
AYTT
K
H
--------
Q
I
K
L
V
I
T
TVSSPK--------M--------KNMPDSL
H
A
-
I
D
W
I
ITNKDET
E
T
Y
L
N
LKI
34
HHSearch
89.22
24%
-99
- C2 -
3KZH
1
?
A:
[4-199]
------------------------------------------------------
R
K
E
P
Y
L
L
V
F
G
A
S
V
V
D
V
F
G
F
S
K
-
A
S
Y
R
P
-------------------
Y
--------------------
N
---------------------
S
-
T
-
P
-
G
-
H
-
V
K
I
S
F
G
G
V
C
R
N
I
A
E
N
M
A
R
V
-----
G
----
V
---
N
T
N
F
M
S
I
L
G
N
D
E
H
G
K
S
I
V
-
E
H
S
-------
K
K
I
G
-
Y
H
M
D
D
S
M
V
I
-
E
G
G
S
T
P
T
Y
L
A
I
L
D
-
E
N
G
E
M
V
S
A
I
A
D
M
K
-
S
-
I
G
A
M
N
T
D
---
F
I
D
S
--
K
R
--
E
I
F
E
N
A
E
Y
T
V
L
D
S
D
N
-----
P
------
E
I
M
E
Y
L
L
K
N
F
K
-
D
--------
K
T
N
F
I
L
D
P
V
S
A
E
K
--------
A
--------
S
W
V
K
H
L
I
K
D
-
F
H
T
I
K
P
N
R
H
E
A
E
I
L
A
G
F
--
1
PsiBlast_PDB
87.50
27%
-103
- C2 -
2NWH
3
?
A:
[6-198]
-----------------------------------------------------------
I
L
V
L
G
G
A
H
I
D
R
R
G
M
I
E
-
T
E
T
A
P
-------------------
G
--------------------
A
---------------------
S
-
N
-
P
-
G
-
S
-
W
M
E
E
A
G
G
G
G
F
N
A
A
R
N
L
S
R
L
-----
G
----
F
---
E
V
R
I
I
A
P
R
G
G
D
V
T
G
E
V
V
A
-
E
A
A
R
Q
A
GVED
T
-
P
F
-
T
F
L
D
R
--------
R
T
P
S
Y
T
A
I
L
E
-
R
D
G
N
L
V
I
A
L
A
D
M
D
-
L
-
Y
K
L
F
T
P
R
---
R
L
K
V
--
R
A
V
R
E
A
I
I
A
S
D
F
L
L
C
D
A
N
L
-----
P
-----
E
D
T
L
T
A
L
G
L
I
A
R
A
C
--------
E
K
P
L
A
A
I
A
I
S
P
A
K
--------
A
--------
V
K
L
K
A
A
L
G
D
-
I
D
I
L
F
M
N
E
A
E
A
--------
7
PsiBlast_PDB
87.10
25%
-103
- C2 -
3KZH
1
?
A:
[9-186]
-----------------------------------------------------------
L
L
V
F
G
A
S
V
V
D
V
F
G
F
S
K
-
A
S
Y
R
P
-------------------
Y
--------------------
N
---------------------
S
-
T
-
P
-
G
-
H
-
V
K
I
S
F
G
G
V
C
R
N
I
A
E
N
M
A
R
V
-----
G
----
V
---
N
T
N
F
M
S
I
L
G
N
D
E
H
G
K
S
I
V
-
E
H
S
-------
K
-
K
I
G
Y
H
M
D
D
S
M
V
I
-
E
G
G
S
T
P
T
Y
L
A
I
L
D
-
E
N
G
E
M
V
S
A
I
A
D
M
K
-
S
-
I
G
A
M
N
T
D
---
F
I
D
S
--
K
R
--
E
I
F
E
N
A
E
Y
T
V
L
D
S
D
------
N
-----
P
E
I
M
E
Y
L
L
K
-
N
F
K
D
--------
K
T
N
F
I
L
D
P
V
S
A
E
K
A
S
W
-----
V
--------
K
H
L
I
K
D
F
H
T
-
I
------------------
41
HHSearch
84.26
18%
-97
- C2 -
2QCV
2
IOLC_BACHD
A:
[9-221]
------------------------------------------------------
D
R
E
F
D
L
I
A
I
G
R
A
C
I
D
L
N
A
V
E
Y
-
N
R
P
M
E
-------------------
E
--------------------
T
---------------------------
M
-
T
-
F
S
K
Y
V
G
G
S
P
A
N
I
V
I
G
S
S
K
L
-----
G
----
L
---
K
A
G
F
I
G
K
I
A
D
D
Q
H
G
R
F
I
E
-
S
Y
M
-------
R
G
V
G
-
V
D
T
S
N
L
V
V
D
Q
E
G
H
K
T
G
L
A
F
T
E
I
K
-
S
P
E
E
C
S
I
L
M
Y
R
Q
D
V
A
-
D
L
Y
L
S
P
E
---
E
V
N
E
------
A
Y
I
R
R
S
K
L
L
L
V
S
G
T
A
LSKS
P
S
-----
R
E
A
V
L
K
A
I
R
L
A
K
R
N
--------
D
V
K
V
V
F
E
L
D
Y
R
P
Y
--------
S
WET
P
E
E
T
A
V
Y
Y
S
L
V
A
E
Q
-
S
D
I
V
I
G
T
R
E
E
F
D
V
L
E
N
R
--
38
HHSearch
74.95
15%
-80
- C2 -
2RBC
9
?
A:
[28-220]
-------------------------------------------------------
G
G
K
H
V
L
C
V
G
A
A
V
L
D
T
L
F
R
V
A
-
D
M
P
K
G
-------------------
E
--------------------
G
---------------------
K
-
V
L
P
-
Y
-
E
-
V
L
Q
I
A
E
G
M
A
S
S
A
A
Y
A
V
H
R
M
-----
G
----
G
---
R
A
S
L
W
G
A
V
G
D
D
E
T
G
T
R
I
L
-
R
D
L
-------
S
E
S
G
-
I
D
T
S
G
M
T
V
A
-
P
G
A
R
S
A
L
S
T
I
I
I
D
-
N
R
G
E
R
L
I
V
P
F
Y
D
H
-
R
--
L
H
E
K
K
R
---
A
C
T
----
P
--
E
D
I
A
L
F
D
A
V
L
V
D
V
R
W
-----
P
------
E
L
A
L
D
V
L
T
V
A
R
A
L
--------
G
K
P
A
I
L
D
G
D
V
A
P
---------
V
--------
E
T
L
E
G
L
A
P
A
-
A
T
H
I
V
F
S
E
P
A
A
T
R
L
T
G
L
--
35
HHSearch
73.86
20%
-85
- C2 -
3RY7
2
?
A:
[2-196]
--------------------------------------------------------
T
N
K
V
V
I
L
G
S
T
N
V
D
Q
F
L
T
V
E
-
R
Y
A
Q
P
-------------------
G
--------------------
E
---------------------
T
-
L
-
H
-
V
E
E
A
Q
K
A
F
G
G
G
K
G
A
N
Q
A
I
A
T
A
R
M
-----
Q
----
A
---
D
T
T
F
I
T
K
I
G
T
D
G
V
A
D
F
I
L
-
E
D
F
-------
K
V
A
H
-
I
D
T
S
Y
I
I
K
T
-
A
E
A
K
T
G
Q
A
F
I
T
V
N
-
A
E
G
Q
N
T
I
Y
V
Y
G
-
G
-
A
-
N
M
T
M
T
P
E
---
D
V
I
N
--
A
K
--
D
A
I
I
N
A
D
F
V
V
A
Q
L
E
V
-----
P
-----
I
P
A
I
I
S
A
F
E
I
A
K
A
H
--------
G
V
T
T
V
L
N
P
A
P
A
K
------------------
A
L
P
N
E
L
L
S
L
-
I
D
I
I
V
P
N
E
T
E
A
E
L
L
S
G
I
--
5
PsiBlast_PDB
69.99
24%
-82
- C2 -
1GQT
2
RBSK_ECOLI
A:
[39-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
-------
T
-
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
-
H
A
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
--
M
A
A
A
K
I
A
H
--------
Q
N
K
T
I
V
A
L
N
P
A
P
A
-----------------
R
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
50
HHSearch
69.86
15%
-89
- C2 -
1BX4
5
ADK_HUMAN
A:
[4-233]
------------------------------------------------------
V
R
E
N
I
L
F
G
M
G
N
P
L
L
D
I
S
A
V
V
D
-
K
D
F
L
D
-------------------
K
Y
SLKP
N
D
Q
I
L
A
E
DKH
K
E
L
F
D
E
---------------------
L
V
K
-
K
-
F
-
K
-
V
E
Y
H
A
G
G
S
T
Q
N
S
I
K
V
A
Q
W
M
-----
I
QQPH
K
---
A
A
T
F
F
G
C
I
G
I
D
K
F
G
E
I
L
K
-
R
K
A
-------
A
E
A
H
-
V
D
A
H
Y
Y
E
-
Q
-
N
E
Q
P
T
G
T
C
A
A
C
I
T
-
G
D
-
N
R
S
L
I
A
N
L
A
A
-
A
--
N
C
Y
K
K
E
KHL
D
L
E
K
--
N
W
--
M
L
V
E
K
A
R
V
C
Y
I
A
G
F
F
LTV--
S
-----
P
E
S
V
L
K
V
A
H
H
A
S
E
N
--------
N
R
I
F
T
L
N
L
S
A
P
F
I
S
Q
FY----
K
--------
E
S
L
M
K
V
M
P
Y
-
V
D
I
L
F
G
N
E
T
E
A
A
T
F
A
R
E
--
37
HHSearch
69.65
16%
-81
- C2 -
3GO6
1
?
A:
[19-208]
--------------------------------------------------------
A
P
R
V
C
V
V
G
S
V
N
M
D
L
T
F
V
V
D
-
A
L
P
R
P
-------------------
G
--------------------
E
---------------------
T
-
V
L
A
-
A
-
S
-
L
T
R
T
P
G
G
K
G
A
N
Q
A
V
A
A
A
R
A
-----
G
----
A
---
Q
V
Q
F
S
G
A
F
G
D
D
P
A
A
A
Q
L
R
-
A
H
L
-------
R
A
N
A
-
V
G
L
D
R
T
V
T
V
-
P
-
G
P
S
G
T
A
I
I
V
V
D
-
A
S
A
E
N
T
V
L
V
-
A
P
G
-
A
-
N
A
H
L
T
P
V
---
P
---------
S
A
V
A
N
C
D
V
L
L
T
Q
L
E
I
-----
P
-----
V
A
T
A
L
A
A
A
R
A
A
Q
S
A
--------
D
A
V
V
M
V
N
A
S
P
A
G
Q
D-------
R
--------
S
S
L
Q
D
L
A
A
I
-
A
D
V
V
I
A
N
E
H
E
A
N
D
W
P
S
---
36
HHSearch
69.22
18%
-82
- C2 -
1RKD
4
RBSK_ECOLI
A:
[4-197]
--------------------------------------------------------
A
G
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
Q
-
S
F
P
T
P
-------------------
G
--------------------
E
---------------------
T
-
V
-
T
-
G
N
H
-
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
-
Q
Q
L
-------
A
T
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
H
A
-
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
--------
K
T
I
V
A
L
N
P
A
P
A
R
------------------
E
L
P
D
E
L
L
A
L
-
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
--
4
PsiBlast_PDB
69.21
24%
-84
- C2 -
1RKS
2
RBSK_ECOLI
A:
[39-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
-------
T
-
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
-
H
A
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
--
M
A
A
A
K
I
A
H
--------
Q
N
K
T
I
V
A
L
N
P
A
P
A
-----------------
R
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
2
PsiBlast_PDB
68.00
24%
-82
- C2 -
1RK2
3
RBSK_ECOLI
A:
[39-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
-------
T
-
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
-
H
A
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
--
M
A
A
A
K
I
A
H
--------
Q
N
K
T
I
V
A
L
N
P
A
P
A
-----------------
R
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
3
PsiBlast_PDB
67.81
24%
-82
- C2 -
1RKA
-
RBSK_ECOLI
A:
[39-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
-------
T
-
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
-
H
A
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
--
M
A
A
A
K
I
A
H
--------
Q
N
K
T
I
V
A
L
N
P
A
P
A
-----------------
R
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
33
HHSearch
67.56
16%
-84
- C2 -
2FV7
5
RBSK_HUMAN
A:
[24-218]
--------------------------------------------------------
V
A
A
V
V
V
V
G
S
C
M
T
D
L
V
S
L
T
S
-
R
L
P
K
T
-------------------
G
--------------------
E
---------------------
T
-
I
-
H
-
G
H
K
-
F
F
I
G
F
G
G
K
G
A
N
Q
C
V
Q
A
A
R
L
-----
G
----
A
---
M
T
S
M
V
C
K
V
G
K
D
S
F
G
N
D
Y
I
-
E
N
L
-------
K
Q
N
D
-
I
S
T
E
F
T
Y
Q
T
-
K
D
A
A
T
G
T
A
S
I
I
V
N
-
N
E
G
Q
N
I
I
V
I
V
-
A
G
-
A
-
N
L
L
L
N
T
E
---
D
L
R
A
--
A
A
--
N
V
I
S
R
A
K
V
M
V
C
Q
L
E
I
-----
T
-----
P
A
T
S
L
E
A
L
T
M
A
R
R
S
--------
G
V
K
T
L
F
N
P
A
P
A
I
---------
A
--------
D
L
D
P
Q
F
Y
T
L
-
S
D
V
F
C
C
N
E
S
E
A
E
I
L
T
G
L
--
6
PsiBlast_PDB
67.25
24%
-78
- C2 -
1RKD
3
RBSK_ECOLI
A:
[39-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
-----
G
----
A
---
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
-------
T
-
D
N
-
I
D
I
T
P
V
S
V
I
-
K
G
E
S
T
G
V
A
L
I
F
V
N
-
G
E
G
E
N
V
I
G
I
-
H
A
G
-
A
-
N
A
A
L
S
P
A
---
L
V
E
A
--
Q
R
--
E
R
I
A
N
A
S
A
L
L
M
Q
L
E
S
-----
P
-----
L
E
S
V
--
M
A
A
A
K
I
A
H
--------
Q
N
K
T
I
V
A
L
N
P
A
P
A
-----------------
R
E
L
P
D
E
L
L
A
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
42
HHSearch
67.15
18%
-76
- C2 -
3IKH
1
?
A:
[2-193]
--------------------------------------------------------
S
L
R
V
Y
V
T
G
N
I
T
V
D
E
T
W
S
I
P
-
D
I
P
K
K
-------------------
G
--------------------
A
---------------------
S
-
I
-
H
-
G
V
K
-
V
S
Q
D
I
G
G
K
G
A
N
Q
A
I
I
L
S
R
C
-----
G
----
I
---
E
T
R
L
I
A
A
T
G
N
D
S
N
G
A
W
I
R
-
Q
Q
I
-------
K
N
E
P
-
L
M
L
L
P
D
G
H
--
F
N
Q
H
S
D
T
S
I
I
L
N
S
-
A
D
G
D
N
A
I
I
T
T
-
T
A
-
A
-
A
D
T
F
S
L
D
---
E
M
I
P
--
H
M
--
A
D
A
V
A
G
D
I
L
L
Q
Q
G
N
F
-----
S
-----
L
D
K
T
R
A
L
F
Q
Y
A
R
S
R
--------
G
M
T
T
V
F
N
P
S
P
V
N
------------------
P
D
F
C
H
L
W
P
L
-
I
D
I
A
V
V
N
E
S
E
A
E
L
L
Q
P
---
45
HHSearch
66.80
16%
-85
- C2 -
3LJS
-
?
A:
[4-222]
--------------------------------------------------------
K
K
T
I
L
C
F
G
E
A
L
I
D
M
L
A
Q
P
L
-
V
--
K
K
-------------------
G
--------------------------------------------
M
-
P
-
R
-
A
-
F
L
Q
C
A
G
G
A
P
A
N
V
A
V
A
V
A
R
L
-----
G
----
G
---
A
V
Q
F
V
G
M
L
G
S
D
M
F
G
D
F
L
F
-
D
S
F
-------
A
E
A
G
-
V
V
T
D
G
I
V
R
T
-
S
T
A
K
T
A
L
A
F
V
A
L
D
-
A
H
G
E
R
S
F
S
F
Y
R
P
P
-
A
A
D
L
L
F
R
V
E
---
H
F
Q
D
------
A
S
F
S
D
A
L
I
F
H
A
C
S
N
S
-----
M
TD
A
D
I
A
E
V
T
F
E
G
M
R
R
A
Q
A
A
--------
G
A
I
V
S
F
D
L
N
F
R
P
M
LWPNGENP
A
--------
S
R
L
W
K
G
L
S
L
-
A
D
V
V
K
L
S
S
E
E
L
D
Y
L
A
N
T
--
47
HHSearch
65.00
13%
-84
- C2 -
3OTX
1
?
A:
[6-238]
-------------------------------------------------------
A
P
L
R
V
Y
V
Q
C
N
P
L
L
D
V
S
A
H
V
S
D
E
F
L
V
K
Y
GLERG
T
A
I
L
LSERQKG
I
F
D
--------------------
D
---------------------
I
E
K
-
M
-
P
-
N
-
V
R
Y
V
P
G
G
S
G
L
N
V
A
R
V
A
Q
W
M
Q
QAYK
G
----
K
---
F
V
T
Y
V
G
C
I
A
D
D
R
Y
G
K
V
L
K
-
E
A
A
-------
E
H
E
G
-
I
V
M
A
V
E
H
-
T
-
T
K
A
G
S
G
A
C
A
V
C
I
T
--
G
K
E
R
T
L
V
A
-
D
L
G
-
A
-
A
N
H
L
S
S
E
---
H
M
R
S
P
A
V
V
--
R
A
M
D
E
S
R
I
F
Y
F
S
G
F
T
-----
L
TVD--
V
N
H
V
L
Q
A
C
R
K
A
R
E
V
--------
D
G
L
F
M
I
N
L
S
A
P
F
I
M
Q
FF----
S
--------
A
Q
L
G
E
V
L
P
Y
-
T
D
I
I
V
A
N
R
H
E
A
K
E
F
A
N
M
--
52
HHSearch
63.16
16%
-75
- C2 -
2HLZ
4
KHK_HUMAN
A:
[17-213]
--------------------------------------------------------
G
S
Q
I
L
C
V
G
L
V
V
L
D
V
I
S
L
V
D
-
K
Y
P
K
E
-------------------
D
--------------------
S
---------------------
E
-
I
-
R
C
L
-
S
-
Q
R
W
Q
R
G
G
N
A
S
N
S
C
T
I
L
S
L
L
-----
G
----
A
---
P
C
A
F
M
G
S
M
A
P
G
H
V
A
D
F
V
L
-
D
D
L
-------
R
R
Y
S
-
V
D
L
R
Y
T
V
F
Q
-
T
T
G
S
V
P
I
A
T
V
I
I
N
E
A
S
G
S
R
T
I
L
Y
Y
-
D
R
-
S
-
L
P
D
V
S
A
T
---
D
F
E
K
------
V
D
L
T
Q
F
K
W
I
H
I
E
G
R
N
-----
A
-----
S
E
-
Q
V
K
M
L
Q
R
I
D
A
H
N
T
R
QPPEQ
K
I
R
V
S
V
E
V
E
K
P
----------
R
--------
E
E
L
F
Q
L
F
G
Y
-
G
D
V
V
F
V
S
K
D
V
A
K
H
L
-----
43
HHSearch
59.12
12%
-89
- C2 -
3VAS
2
?
A:
[21-250]
-----------------------------------------------------
D
L
S
E
G
Y
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
-
D
F
M
Y
R
-------------------
K
--------------------
Y
NLKKD
N
I
V
L
A
EEKHMT
I
Y
D
E
I
Q
-
K
-
K
-
K
-
K
-
L
N
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
-----
I
----
Q
KPF
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
-
N
D
C
-------
S
A
L
D
-
L
V
T
E
F
Q
I
A
E
-
E
P
L
M
T
G
K
V
A
V
L
V
S
--
E
K
L
R
S
M
V
T
Y
-
L
G
-
A
-
A
C
D
L
S
L
A
---
H
I
E
Q
P
H
V
W
--
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
-----
I
NTC--
Y
E
G
M
L
K
I
A
K
H
S
L
E
N
--------
E
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
FN----
T
--------
K
E
V
D
E
M
I
S
Y
-
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
--