@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0449: (2016-03-15 )
MLIDTHVHLNDEQYDDDLSEVITRAREAGVDRMFVVGFNKSTIERAMKLIDEYDFLYGIIGWHPVDAIDFTEEHLEWIESLAQHPKVIGIGEMGLDYHWDKSPADVQKEVFRKQIALAKRLKLPIIIHNREATQDCIDILLEEHAEEVGGIMHSFSGSPEIADIVTNKLNFYISLGGPVTFKNAKQPKEVAKHVSMERLLVETDAPYLSPHPYRGKRNEPARVTLVAEQIAELKGLSYEEVCEQTTKNAEKLFNLNS
Atome Classification :
(20 SA)
.........10----------....----------.---...20........30........40........50...----.-----....60........70---.-..----.----------.....-80..--.--.-....90......-..100-..----......----110.......120........130..-.....140.......150-.......160.......-170.......180..-......190.......200.....-----.-------------.210-.----.---------------------.----.---------...220.......230.......240.......250.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
I
D
T
H
V
H
LN
D
----------
E
QYD----------
D
---
D
L
S
E
V
I
T
R
A
R
EAGV
D
R
M
F
V
VGF
N
K
S
T
I
E
R
A
M
K
L
I
D
E
Y
D
----
F
-----
L
Y
G
IIGWHPV
D
A
IDF----
T
-
E
E
----
H
----------
L
E
W
I
E
-
S
L
AQ--H--P-
K
V
I
G
I
GEMG
L
D
Y-HWD-K-S
P
----
A
D
V
Q
K
E
----
V
F
R
K
Q
I
A
L
A
K
RL-KL
P
I
I
I
HNREA
T
Q
-
D
C
I
D
I
L
L
E
E
H
A
E
E
V
G
G
I
M
-
H
SFSGS
P
E
I
A
D
I
VTNK
L
-
N
F
Y
I
SLGG
P
V
T-FKN-AK
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
VETDAPY-----L-------------SPHP-Y----R---------------------G----K---------RNEP
A
R
V
T
L
V
A
E
Q
I
A
E
L
KGL
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
LFNLNS
1
PsiBlast_PDB
99.71
98%
-117
- C2 -
2GZX
2
?
A:
[2-254]
-
L
I
D
T
H
V
H
L
N
D
----------
E
Q
Y
D
----------
D
---
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
R
A
M
K
L
I
D
E
Y
D
----
F
-----
L
Y
G
I
I
G
W
H
P
V
D
A
I
D
F
----
T
-
E
E
----
H
----------
L
E
W
I
E
-
S
L
A
Q
--
H
--
P
-
K
V
I
G
I
G
E
M
G
L
D
Y
-
H
W
D
-
K
-
S
P
----
A
D
V
Q
K
E
----
V
F
R
K
Q
I
A
L
A
K
R
L
-
K
L
P
I
I
I
H
N
R
E
A
T
Q
-
D
C
I
D
I
L
L
E
E
H
A
E
E
V
G
G
I
M
-
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
K
L
-
N
F
Y
I
S
L
G
G
P
V
T
-
F
K
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
-------------
S
P
H
P
-
Y
----
R
---------------------
G
----
K
---------
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
---
22
HHSearch
97.04
96%
-110
- C2 -
2GZX
2
?
A:
[2-254]
-
L
I
D
T
H
V
H
L
N
D
----------
E
Q
Y
D
----------
D
---
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
R
A
M
K
L
I
D
E
Y
D
----
F
-----
L
Y
G
I
I
G
W
H
P
V
D
A
I
D
F
----
T
-
E
E
----
H
----------
L
E
W
I
E
-
S
L
A
Q
--
H
--
P
-
K
V
I
G
I
G
E
M
G
L
D
Y
-
H
W
D
-
K
-
S
P
----
A
D
V
Q
K
E
----
V
F
R
K
Q
I
A
L
A
K
R
L
-
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
I
L
L
E
E
H
A
-
E
E
V
G
G
I
M
-
H
S
F
S
G
S
P
E
I
A
D
I
V
T
-
N
K
L
N
F
Y
I
S
L
G
G
P
V
T
-
F
K
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
-------------
S
P
H
P
-
Y
----
R
---------------------
G
----
K
---------
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
---
20
PsiBlast_CBE
77.73
33%
-117
- C2 -
2Y1H
6
TATD3_HUMAN
B:
[6-263]
-
L
V
D
C
H
C
H
L
S
A
----------
P
D
F
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
R
Y
N
G---
F
-----
V
L
P
C
L
G
V
H
P
V
Q
G
L
--------
D
Q
----
R
S
V
T
L
K
D
L
D
V
A
L
P
I
I
E
-
N
Y
K
D
-------
R
L
L
A
I
G
E
V
G
L
D
F
-
S
P
R
-
F
-
A
G
----
T
G
E
Q
K
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
-
N
L
P
V
N
V
H
S
R
S
A
G
R
-
P
T
I
N
L
L
Q
E
Q
G
A
E
K
V
--
L
L
-
H
A
F
D
G
R
P
S
V
A
-
M
E
G
V
R
A
-
G
Y
F
F
S
I
--
P
P
S
-
I
I
R
-
S
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
-------------
G
P
E
-------
K
---------------------
Q
----
V
---------
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
----
4
PsiBlast_PDB
77.61
33%
-118
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[6-263]
-
L
V
D
C
H
C
H
L
S
A
----------
P
D
F
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
R
Y
N
G---
F
-----
V
L
P
C
L
G
V
H
P
V
Q
----------------
R
SVT
L
K
D
L
D
V
A
L
P
I
I
E
-
N
Y
K
D
-------
R
L
L
A
I
G
E
V
G
L
D
F
-
S
P
R
-
F
-
A
G
----
T
G
E
Q
K
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
-
N
L
P
V
N
V
H
S
R
S
A
G
R
-
P
T
I
N
L
L
Q
E
Q
G
A
E
K
V
--
L
L
-
H
A
F
D
G
R
P
S
V
A
-
M
E
G
V
R
A
-
G
Y
F
F
S
I
--
P
P
S
-
I
I
R
-
S
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
-------------
G
P
E
-------
K
---------------------
Q
----
V
---------
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
----
2
PsiBlast_PDB
76.55
39%
-102
- C2 -
1J6O
-
?
A:
[1-250]
--
V
D
T
H
A
H
L
H
F
----------
H
Q
F
D
----------
D
---
D
R
N
A
V
I
S
S
F
E
E
N
N
I
E
F
V
V
N
V
G
V
N
L
E
D
S
K
K
S
L
D
L
S
K
T
S
D
----
R
-----
I
F
C
S
V
G
V
H
P
H
D
A
K
E
V
----
P
-
E
D
----
F
----------
I
E
H
L
E
-
K
F
A
K
--
D
--
E
-
K
V
V
A
I
G
E
T
G
L
D
F
-
F
R
N
-
I
-
S
P
----
A
E
V
Q
K
R
----
V
F
V
E
Q
I
E
L
A
G
K
L
-
N
L
P
L
V
V
H
I
R
D
A
Y
S
-
E
A
Y
E
I
L
R
T
E
S
L
P
E
K
R
G
V
I
-
H
A
F
S
S
D
Y
E
W
A
K
K
F
I
D
-
L
-
G
F
L
L
G
I
G
G
P
V
T
-
Y
P
K
-
N
E
A
L
R
E
V
V
K
R
V
G
L
E
Y
I
V
L
E
T
D
C
P
F
-----
L
-------------
P
P
Q
P
-
F
----
R
---------------------
G
----
K
---------
R
N
E
P
K
Y
L
K
Y
V
V
E
T
I
S
Q
V
L
G
V
P
E
A
K
V
D
E
A
T
T
E
N
A
R
R
I
F
----
30
HHSearch
76.52
33%
-96
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[5-266]
G
L
V
D
C
H
C
H
L
S
A
----------
P
D
F
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
R
Y
N
----
G
F----
V
L
P
C
L
G
V
H
P
V
Q
----RSV-
T
-
L
K
----
D
----------
L
D
V
A
L
-
P
I
I
E
N
Y
K
--
D
-
R
L
L
A
I
G
E
V
G
L
D
F
-
S
P
R
-
F
-
A
G
T
G
E
Q
K
E
E
Q
R
Q
----
V
L
I
R
Q
I
Q
L
A
K
R
L
-
N
L
P
V
N
V
H
S
R
S
A
G
R
-
P
T
I
N
L
L
Q
E
Q
G
-
A
-
E
K
V
L
L
-
H
A
F
D
G
R
P
S
V
A
M
E
G
V
-
R
A
-
G
Y
F
F
S
I
P
P
S
I
I
-
R
S
---
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
-------------
G
P
E
K
----------------------------
Q
----
V
---------
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
-
28
HHSearch
76.46
31%
-95
- C2 -
2XIO
3
TATD1_HUMAN
A:
[2-293]
K
F
I
D
I
G
I
N
L
T
D
----------
P
M
F
R
GIYRGVQKHQ
D
---
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
D
A
L
H
L
A
Q
T
N
G
----
M
-----
F
F
S
T
V
G
C
H
P
T
R
C
G
E
F
E
K
N
N
P
-
D
L
----
Y
----------
L
K
E
L
L
-
N
L
A
E
N
N
K
--
G
-
K
V
V
A
I
G
E
C
G
L
D
F
-
D
R
L
Q
F
-
C
P
----
K
D
T
Q
L
K
----
Y
F
E
K
Q
F
E
L
S
E
Q
T
-
K
L
P
M
F
L
H
C
R
N
S
H
A
-
E
F
L
D
I
T
K
R
N
R
D
R
C
V
G
G
V
V
-
H
S
F
D
G
T
K
E
A
A
A
A
L
I
-
D
L
-
D
L
Y
I
G
F
N
G
C
S
L
-
K
T
---
E
A
N
L
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
-------------
G
V
K
S
T
H
----
A
GSKYIRTAFPTKKKWESGHCL
K
----
D
---------
R
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
V
-
26
HHSearch
76.22
30%
-102
- C2 -
1XWY
1
TATD_ECOLI
A:
[5-263]
-
M
F
D
I
G
V
N
L
T
S
----------
S
Q
F
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
Q
Y
S
----
S
-----
C
W
S
T
A
G
V
H
P
H
D
S
S
Q
W
----
Q
-
A
A
----
T
----------
E
E
A
I
I
-
E
L
A
A
--
Q
--
P
-
E
V
V
A
I
G
E
C
G
L
D
F
-
N
R
N
-
F
-
S
T
----
P
E
E
Q
E
R
----
A
F
V
A
Q
L
R
I
A
A
D
L
-
N
M
P
V
F
M
H
C
R
D
A
H
E
-
R
F
M
T
L
L
E
P
W
L
D
K
L
P
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
-
A
H
-
G
I
Y
I
G
I
T
G
W
V
C
-
D
E
R
R
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
-------------
L
P
R
D
-
L
----
T
PKPS-----------------
S
----
R
---------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
-
6
PsiBlast_PDB
75.42
29%
-102
- C2 -
1XWY
1
TATD_ECOLI
A:
[5-262]
-
M
F
D
I
G
V
N
L
T
S
----------
S
Q
F
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
Q
Y
S
----
S
-----
C
W
S
T
A
G
V
H
P
H
D
S
S
Q
W
----
Q
-
A
A
----
T
----------
E
E
A
I
I
-
E
L
A
A
--
Q
--
P
-
E
V
V
A
I
G
E
C
G
L
D
F
-
N
R
N
-
F
-
S
T
----
P
E
E
Q
E
R
----
A
F
V
A
Q
L
R
I
A
A
D
L
-
N
M
P
V
F
M
H
C
R
D
A
H
E
-
R
F
M
T
L
L
E
P
W
L
D
K
L
P
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
-------------
T
P
K
P
------
S
---------------------
S
----
R
---------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
--
19
PsiBlast_CBE
75.39
36%
-97
- C2 -
1YIX
2
YCFH_ECOLI
B:
[2-258]
F
L
V
D
S
H
C
H
L
D
G
----------
L
D
Y
E
----------
S
LHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
E
R
D
----
N
-----
V
V
F
S
C
G
V
H
P
L
N
Q
N
D
P
----
Y
-
D
----------------
V
E
D
L
R
-
R
L
A
A
--
E
--
E
-
G
V
V
A
L
G
E
T
G
L
D
Y
-
Y
Y
T
-
P
-
E
T
----
K
V
R
Q
Q
E
----
S
F
I
H
H
I
Q
I
G
R
E
L
-
N
K
P
V
I
V
H
T
R
D
A
R
A
-
D
T
L
A
I
L
R
E
E
K
V
T
D
C
G
G
V
L
-
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
-
L
-
G
F
Y
I
S
F
S
G
I
V
T
-
F
R
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
-------------
A
P
V
P
-
H
----
R
---------------------
G
----
K
---------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
10
PsiBlast_PDB
75.14
28%
-104
- C2 -
2XIO
3
TATD1_HUMAN
A:
[3-290]
-
F
I
D
I
G
I
N
L
T
D
PMFRGIYRGV
Q
K
H
Q
----------
D
---
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
D
A
L
H
L
A
Q
T
N
G
----
M
-----
F
F
S
T
V
G
C
H
P
T
R
C
G
E
F
----
E
-
K
N
N
P
D
L
Y
----------
L
K
E
L
L
-
N
L
A
E
--
N
N
K
G
-
K
V
V
A
I
G
E
C
G
L
D
F
D
R
L
Q
-
F
-
C
P
----
K
D
T
Q
L
K
----
Y
F
E
K
Q
F
E
L
S
E
Q
T
-
K
L
P
M
F
L
H
C
R
N
S
H
A
-
E
F
L
D
I
T
K
R
N
R
D
R
C
V
G
G
V
V
-
H
S
F
D
G
T
K
E
A
A
A
A
L
I
D
-
L
-
D
L
Y
I
G
F
N
G
C
S
L
-
K
T
E
-
A
N
L
--
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
GVKSTHAGSKYIR
T
A
F
P
-
T
----
K
---------------------
K
----
K
WESGHCLKD
R
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
----
3
PsiBlast_PDB
75.11
36%
-99
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-258]
F
L
V
D
S
H
C
H
L
D
G
----------
L
D
Y
E
----------
S
LHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
E
R
D
----
N
-----
V
V
F
S
C
G
V
H
P
L
N
Q
N
D
P
----
Y
-
D
----------------
V
E
D
L
R
-
R
L
A
A
--
E
--
E
-
G
V
V
A
L
G
E
T
G
L
D
Y
-
Y
Y
T
-
P
-
E
T
----
K
V
R
Q
Q
E
----
S
F
I
H
H
I
Q
I
G
R
E
L
-
N
K
P
V
I
V
H
T
R
D
A
R
A
-
D
T
L
A
I
L
R
E
E
K
V
T
D
C
G
G
V
L
-
H
C
F
T
E
D
R
E
T
A
G
K
L
L
D
-
L
-
G
F
Y
I
S
F
S
G
I
V
T
-
F
R
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
-------------
A
P
V
P
-
H
----
R
---------------------
G
----
K
---------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
A
25
HHSearch
75.09
31%
-99
- C2 -
3RCM
3
?
A:
[2-273]
Q
L
I
D
I
G
V
N
L
T
N
----------
S
S
F
H
----------
D
---
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
Q
A
L
E
L
C
Q
Q
L
D
ASGA
H
-----
L
F
A
T
A
G
V
H
P
H
D
A
K
A
W
----
D
-
T
D
----
S
----------
E
R
Q
L
R
-
L
L
L
S
--
E
--
P
-
R
V
R
A
V
G
E
C
G
L
D
F
-
N
R
D
-
F
-
S
P
----
R
P
L
Q
E
K
----
A
L
E
A
Q
L
T
L
A
A
Q
L
-
R
L
P
V
F
L
H
E
R
D
A
S
E
-
R
L
L
A
I
L
K
D
Y
R
D
-
H
L
T
G
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
-
D
L
-
D
L
H
I
G
I
T
G
W
I
C
-
D
E
R
R
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
-------------
L
P
R
S
-
L
----
R
---------------------
P
KPKS
G
---------
R
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
P
-
9
PsiBlast_PDB
74.95
30%
-90
- C2 -
3RCM
3
?
A:
[3-272]
-
L
I
D
I
G
V
N
L
T
N
----------
S
S
F
H
----------
D
---
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
Q
A
L
E
L
C
Q
Q
L
D
ASGA
H
-----
L
F
A
T
A
G
V
H
P
H
D
A
K
A
W
----
D
-
T
D
----
S
----------
E
R
Q
L
R
-
L
L
L
S
--
E
--
P
-
R
V
R
A
V
G
E
C
G
L
D
F
-
N
R
D
-
F
-
S
P
----
R
P
L
Q
E
K
----
A
L
E
A
Q
L
T
L
A
A
Q
L
-
R
L
P
V
F
L
H
E
R
D
A
S
E
-
R
L
L
A
I
L
K
D
Y
R
D
H
L
T
G
A
V
V
-
H
C
F
T
G
E
R
E
-
A
L
F
A
Y
L
D
L
-
D
L
H
I
G
I
T
G
W
I
C
D
E
R
R
-
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
-------------
L
P
R
S
-
L
----
R
---------------------
P
----
K
PKSG-----
R
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
--
7
PsiBlast_PDB
74.08
29%
-93
- C2 -
4P5U
-
TATD_ECOLI
A:
[1-258]
-
M
F
D
I
G
V
N
L
T
S
----------
S
Q
F
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
Q
Y
S
----
S
-----
C
W
S
T
A
G
V
H
P
H
D
S
S
Q
W
----
Q
-
A
A
----
T
----------
E
E
A
I
I
-
E
L
A
A
--
Q
--
P
-
E
V
V
A
I
G
E
C
G
L
D
F
-
N
R
N
-
F
-
S
T
----
P
E
E
Q
E
R
----
A
F
V
A
Q
L
R
I
A
A
D
L
-
N
M
P
V
F
M
H
C
R
D
A
H
E
-
R
F
M
T
L
L
E
P
W
L
D
K
L
P
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
-------------
T
P
K
P
------
S
---------------------
S
----
R
---------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
--
23
HHSearch
74.06
29%
-101
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[4-259]
R
F
I
D
T
H
C
H
F
D
F
----------
P
P
F
S
----------
G
---
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
R
V
L
A
L
A
E
N
Y
Q
----
P
-----
L
Y
A
A
L
G
L
H
P
G
M
L
E
K
H
----
S
-
D
V
----
S
----------
L
E
Q
L
Q
-
Q
A
L
E
--
R
RP
A
-
K
V
V
A
V
G
E
I
G
L
D
L
-
F
G
D
-
D
-
P
Q
----
F
E
R
Q
Q
W
----
L
L
D
E
Q
L
K
L
A
K
R
Y
-
D
L
P
V
I
L
H
S
R
R
T
H
D
-
K
L
A
M
H
L
K
R
H
D
-
L
P
R
T
G
V
V
-
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
-
Q
L
-
G
Y
K
I
G
V
G
G
T
I
T
-
Y
P
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
-------------
P
L
N
G
-
F
----
Q
---------------------
G
----
Q
---------
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
-
5
PsiBlast_PDB
73.92
30%
-97
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[5-258]
-
F
I
D
T
H
C
H
F
D
F
----------
P
P
F
S
----------
G
---
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
R
V
L
A
L
A
E
N
Y
Q
----
P
-----
L
Y
A
A
L
G
L
H
P
G
M
L
E
K
H
----
S
-
D
V
----
S
----------
L
E
Q
L
Q
Q
A
L
E
R
--
R
--
P
A
K
V
V
A
V
G
E
I
G
L
D
L
-
F
G
D
-
D
-
P
Q
----
F
E
R
Q
Q
W
----
L
L
D
E
Q
L
K
L
A
K
R
Y
-
D
L
P
V
I
L
H
S
R
R
-
T
H
-
D
K
L
A
M
H
L
K
R
H
D
L
P
R
T
G
V
V
-
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
-
Q
L
-
G
Y
K
I
G
V
G
G
T
I
T
-
Y
P
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
-------------
P
L
N
G
-
F
----
Q
---------------------
G
----
Q
---------
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
--
29
HHSearch
73.21
26%
-92
- C2 -
3IPW
1
?
A:
[27-323]
Q
F
I
D
I
G
A
N
L
T
D
----------
D
N
Y
F
GNYHGKHYHE
E
---
D
I
D
V
V
L
Q
R
A
E
R
N
G
L
S
H
I
I
I
T
S
G
C
L
N
D
F
K
K
A
I
E
I
I
N
K
Y
Q
----
N
LTN
I
K
L
V
T
T
I
G
V
H
P
T
R
T
N
E
L
----
K
Q
E
G
----
Y
----------
L
D
E
L
L
-
L
L
C
E
K
N
I
--
D
-
K
V
V
A
I
G
E
I
G
L
D
Y
-
E
R
L
-
Q
F
S
D
----
K
E
T
Q
L
S
----
G
Y
R
T
L
S
I
L
H
Q
K
Y
P
Y
L
P
F
F
F
H
C
R
K
S
W
S
-
D
L
C
Q
L
N
K
E
L
G
Y
N
-
G
C
K
G
V
V
H
C
F
D
G
T
E
E
E
M
N
Q
I
L
-
N
E
-
G
W
D
I
G
V
T
G
N
S
L
-
Q
S
---
I
E
L
L
N
V
M
K
Q
I
P
I
E
R
L
H
I
E
T
D
C
P
Y
-----
C
-------------
G
I
K
K
-
T
SAGF
K
YLKEKDFGVKVEKYQRNKYV-
Q
----
R
---------
R
N
E
P
S
N
I
I
D
I
A
I
I
M
S
S
I
K
H
I
S
L
F
E
F
V
N
K
V
Y
S
N
S
M
N
M
Y
F
P
T
-
8
PsiBlast_PDB
73.21
29%
-94
- C2 -
4PE8
1
TATD_ECOLI
A:
[1-258]
-
M
F
D
I
G
V
N
L
T
S
----------
S
Q
F
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
Q
Y
S
----
S
-----
C
W
S
T
A
G
V
H
P
H
D
S
S
Q
W
----
Q
-
A
A
----
T
----------
E
E
A
I
I
-
E
L
A
A
--
Q
--
P
-
E
V
V
A
I
G
E
C
G
L
D
F
-
N
R
N
-
F
-
S
T
----
P
E
E
Q
E
R
----
A
F
V
A
Q
L
R
I
A
A
D
L
-
N
M
P
V
F
M
H
C
R
D
A
H
E
-
R
F
M
T
L
L
E
P
W
L
D
K
L
P
G
A
V
L
-
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
A
H
--
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
-------------
T
P
K
P
------
S
---------------------
S
----
R
---------
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
--
24
HHSearch
73.01
38%
-92
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-257]
F
L
V
D
S
H
C
H
L
D
G
----------
L
D
Y
E
SLH-------
K
---
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
E
R
D
----
N
-----
V
V
F
S
C
G
V
H
P
L
N
Q
N
D
P
-------
Y
----
D
----------
V
E
D
L
R
-
R
L
A
A
--
E
--
E
-
G
V
V
A
L
G
E
T
G
L
D
Y
-
Y
Y
T
-
P
-
E
T
----
K
V
R
Q
Q
E
----
S
F
I
H
H
I
Q
I
G
R
E
L
-
N
K
P
V
I
V
H
T
R
D
A
R
A
-
D
T
L
A
I
L
R
E
E
K
-
V
T
D
C
G
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
-
D
L
-
G
F
Y
I
S
F
S
G
I
V
T
-
F
R
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
-------------
A
P
V
P
-
H
----
R
---------------------
G
----
K
---------
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
-