@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0545: (2016-03-16 )
MADLLNVLKDKLSGKNVKIVLPEGEDERVLTAATQLQATDYVTPIVLGDETKVQSLAQKLDLDISNIELINPATSELKAELVQSFVERRKGKATEEQAQELLNNVNYFGTMLVYAGKADGLVSGAAHSTGDTVRPALQIIKTKPGVSRTSGIFFMIKGDEQYIFGDCAINPELDSQGLAEIAVESAKSALSFGMDPKVAMLSFSTKGSAKSDDVTKVQEAVKLAQQKAEEEKLEAIIDGEFQFDAAIVPGVAEKKAPGAKLQGDANVFVFPSLEAGNIGYKIAQRLGGYDAVGPVLQGLNSPVNDLSRGCSIEDVYNLSIITAAQALQ
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70....-...-.80........90-..-......100.......110.......120.......130.......140.......150......------.160------.-----......170.......180.......190.-..-.-....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
D
L
L
N
V
L
K
D
KLSGK
N
V
K
I
V
LPEGEDE
R
V
L
T
A
A
T
Q
LQATD
Y
V
T
P
I
V
LG
D
E
T
K
V
Q
S
L
A
Q
K
LDLDIS
N
I
E
L
INP
A
T
S
-
E
L
K
-
A
E
L
V
Q
S
F
V
E
RRKG-KA-
T
E
E
Q
A
Q
E
L
L
NN
V
N
Y
F
G
T
M
L
V
YAGKADG
L
V
SGAAHSTGD
T
V
R
P
A
L
Q
I
I
KTKPGVSRTS
G
I
F
F
M
I
KG------DE
Q
Y
------
I
-----
F
GDCAINPELDS
Q
G
L
A
E
I
A
V
E
S
A
K
S
A
L
S-F-GM-D-P
K
V
A
M
L
S
FSTKGSAKS
D
D
V
T
K
V
Q
E
A
V
K
L
A
Q
Q
K
A
E
E
E
K
L
E
A
I
IDGE
F
Q
FD
A
A
IVPGVAEKKAPGAKLQGDA
N
V
F
V
F
PSLEAGN
I
G
Y
K
I
A
Q
R
LGGY
D
A
V
G
P
V
L
Q
G
LNS
P
V
N
D
L
SRGCSI
E
D
V
Y
N
L
S
I
I
T
A
A
Q
ALQ
1
PsiBlast_PDB
97.15
97%
-94
- C2 -
4E4R
9
PTAS_STAAR
A:
[5-330]
-
A
D
L
L
N
V
L
K
D
K
L
S
G
K
N
V
K
I
V
L
P
E
G
E
D
E
R
V
L
T
A
A
T
Q
L
Q
A
T
D
Y
V
T
P
I
V
L
G
D
E
T
K
V
Q
S
L
A
Q
K
L
N
L
D
I
S
N
I
E
L
I
N
P
A
T
S
-
E
L
K
-
A
E
L
V
Q
S
F
V
E
R
R
K
G
-
K
T
-
T
E
E
Q
A
Q
E
L
L
N
N
V
N
Y
F
G
T
M
L
V
Y
A
G
K
A
D
G
L
V
S
G
A
A
H
S
T
G
D
T
V
R
P
A
L
Q
I
I
K
T
K
P
G
V
S
R
T
S
G
I
F
F
M
I
K
G
------
D
E
Q
Y
------
I
-----
F
G
D
C
A
I
N
P
E
L
D
S
Q
G
L
A
E
I
A
V
E
S
A
K
S
A
L
S
-
F
-
G
M
-
D
-
P
K
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
D
V
T
K
V
Q
E
A
V
K
L
A
Q
Q
K
A
E
E
E
K
L
E
A
I
I
D
G
E
F
Q
F
D
A
A
I
V
P
G
V
A
E
K
K
A
P
G
A
K
L
Q
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
D
A
V
G
P
V
L
Q
G
L
N
S
P
V
N
D
L
S
R
G
C
S
I
E
D
V
Y
N
L
S
F
I
T
A
A
Q
A
L
-
25
PsiBlast_CBE
86.45
65%
-78
- C2 -
1XCO
4
PTAS_BACSU
B:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
28
PsiBlast_CBE
86.40
65%
-81
- C2 -
1TD9
5
PTAS_BACSU
D:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
23
PsiBlast_CBE
86.38
65%
-79
- C2 -
1XCO
4
PTAS_BACSU
D:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
41
HHSearch
86.32
66%
-84
- C2 -
1TD9
6
PTAS_BACSU
A:
[7-328]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
----
L
T
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
--
29
PsiBlast_CBE
86.31
65%
-79
- C2 -
1TD9
6
PTAS_BACSU
C:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
30
PsiBlast_CBE
86.27
65%
-82
- C2 -
1TD9
5
PTAS_BACSU
B:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
3
PsiBlast_PDB
86.18
65%
-79
- C2 -
1XCO
5
PTAS_BACSU
A:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
26
PsiBlast_CBE
85.99
65%
-80
- C2 -
1TD9
6
PTAS_BACSU
F:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
2
PsiBlast_PDB
85.98
65%
-81
- C2 -
1TD9
6
PTAS_BACSU
A:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
21
PsiBlast_CBE
85.78
65%
-78
- C2 -
1XCO
8
PTAS_BACSU
F:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
24
PsiBlast_CBE
85.70
65%
-78
- C2 -
1XCO
5
PTAS_BACSU
C:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
22
PsiBlast_CBE
85.48
65%
-80
- C2 -
1XCO
4
PTAS_BACSU
E:
[7-329]
M
A
D
L
F
S
T
V
Q
E
K
V
A
G
K
D
V
K
I
V
F
P
E
G
L
D
E
R
I
L
E
A
V
S
K
L
A
G
N
K
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
T
L
G
G
V
K
I
Y
D
P
H
T
Y
-
E
G
M
-
E
D
L
V
Q
A
F
V
E
R
R
K
G
-
K
A
-
T
E
E
Q
A
R
K
A
L
L
D
E
N
Y
F
G
T
M
L
V
Y
K
G
L
A
D
G
L
V
S
G
A
A
H
S
T
A
D
T
V
R
P
A
L
Q
I
I
K
T
K
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
------
E
E
Q
Y
------
V
-----
F
A
D
C
A
I
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
M
-
F
-
D
I
-
E
-
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
E
T
E
K
V
A
D
A
V
K
I
A
K
E
K
A
P
E
L
T
L
----
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
-
5
PsiBlast_PDB
78.81
44%
-72
- C2 -
2AF4
2
PTAS_METTE
C:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
33
PsiBlast_CBE
78.70
44%
-73
- C2 -
1QZT
3
PTAS_METTE
C:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
6
PsiBlast_PDB
78.39
44%
-74
- C2 -
1QZT
5
PTAS_METTE
A:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDG
T
F
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
40
HHSearch
78.33
45%
-72
- C2 -
2AF4
2
PTAS_METTE
C:
[2-329]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
D
L
D
L
--
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
K
G
I
-
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
DCEYGS
D
G
T
F
------
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
D
V
-
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
----
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
A
-
32
PsiBlast_CBE
78.23
44%
-72
- C2 -
1QZT
3
PTAS_METTE
D:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
7
PsiBlast_PDB
78.09
44%
-72
- C2 -
2AF3
3
PTAS_METTE
C:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
34
PsiBlast_CBE
77.82
44%
-74
- C2 -
1QZT
4
PTAS_METTE
B:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
31
PsiBlast_CBE
77.57
44%
-73
- C2 -
2AF3
2
PTAS_METTE
D:
[2-328]
-
V
T
F
L
E
K
I
S
E
R
A
K
K
L
N
K
T
I
A
L
P
E
T
E
D
I
R
T
L
Q
A
A
A
K
I
L
E
R
G
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
--
D
L
D
L
S
K
A
K
I
V
D
P
K
T
Y
-
E
K
K
-
D
E
Y
I
N
A
F
Y
E
L
R
K
H
-
K
G
I
T
L
E
N
A
A
E
I
M
S
D
Y
V
Y
F
A
V
M
M
A
K
L
G
E
V
D
G
V
V
S
G
A
A
H
S
S
S
D
T
L
R
P
A
V
Q
I
V
K
T
A
K
G
A
A
L
A
S
A
F
F
I
I
S
V
P
------
D
C
E
Y
GSDGTF
L
-----
F
A
D
S
G
M
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
L
-
L
-
V
Q
-
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
----
K
L
T
E
A
T
I
A
S
T
K
L
A
Q
E
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
I
A
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
--
42
HHSearch
76.52
40%
-71
* C2 *
1VMI
2
EUTD_ECOLI
A:
[12-335]
-
R
A
I
I
E
R
C
R
E
L
A
L
R
A
P
A
R
V
V
F
P
D
A
L
D
Q
R
V
L
K
A
A
Q
Y
L
H
Q
Q
G
L
A
T
P
I
L
V
A
N
P
F
E
L
R
Q
F
A
L
S
H
G
V
A
M
D
G
L
Q
V
I
D
P
H
G
N
-
L
A
M
R
E
E
F
A
H
R
W
L
A
R
A
G
--
E
K
-
T
P
P
D
A
L
E
K
L
T
D
P
L
M
F
A
A
A
M
V
S
A
G
K
A
D
V
C
I
A
G
N
L
S
S
T
A
N
V
L
R
A
G
L
R
I
I
G
L
Q
P
G
C
K
T
L
S
S
I
F
L
M
L
P
Q
Y
S
----
G
P
A
L
------
G
-----
F
A
D
C
S
V
V
P
Q
P
T
A
A
Q
L
A
D
I
A
L
A
S
A
E
T
W
R
A
I
T
-
G
E
-
E
-
P
R
V
A
M
L
S
F
S
S
N
G
S
A
R
H
P
C
V
A
N
V
Q
Q
A
T
E
I
V
R
E
R
A
P
K
----
L
V
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
R
A
V
G
P
L
I
Q
G
L
A
A
P
M
H
D
L
S
R
G
C
S
V
Q
E
I
I
E
L
A
L
V
A
A
V
P
R
--
8
PsiBlast_PDB
73.02
40%
-70
- C2 -
1VMI
2
EUTD_ECOLI
A:
[28-332]
-----------------
R
V
V
F
P
D
A
L
D
Q
R
V
L
K
A
A
Q
Y
L
H
Q
Q
G
L
A
T
P
I
L
V
A
N
P
F
E
L
R
Q
F
A
L
S
H
G
V
A
M
D
G
L
Q
V
I
D
P
H
G
N
L
A
M
R
-
E
E
F
A
H
R
W
L
A
R
-
A
G
-
E
K
-
T
P
P
D
A
L
E
K
L
T
D
P
L
M
F
A
A
A
M
V
S
A
G
K
A
D
V
C
I
A
G
N
L
S
S
T
A
N
V
L
R
A
G
L
R
I
I
G
L
Q
P
G
C
K
T
L
S
S
I
F
L
M
L
P
---------
Q
Y
------
S
G
P
A
L
G
F
A
D
C
S
V
V
P
Q
P
T
A
A
Q
L
A
D
I
A
L
A
S
A
E
T
W
R
A
-
I
T
G
E
-
E
-
P
R
V
A
M
L
S
F
S
S
N
G
S
A
R
H
P
C
V
A
N
V
Q
Q
A
T
E
I
V
R
E
R
A
P
K
----
L
V
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
G
Y
R
A
V
G
P
L
I
Q
G
L
A
A
P
M
H
D
L
S
R
G
C
S
V
Q
E
I
I
E
L
A
L
V
A
A
-----