@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1101: (2016-03-22 )
MAQISKYKRVVLKLSGEALAGEKGFGINPVIIKSVAEQVAEVAKMDCEIAVIVGGGNIWRGKTGSDLGMDRGTADYMGMLATVMNALALQDSLEQLDCDTRVLTSIEMKQVAEPYIRRRAIRHLEKKRVVIFAAGIGNPYFSTDTTAALRAAEVEADVILMGKNNVDGVYSADPKVNKDAVKYEHLTHIQMLQEGLQVMDSTASSFCMDNNIPLTVFSIMEEGNIKRAVMGEKIGTLITK
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70...-.....80........90........100.......110.......120.......130.......140.......150.......160..-.....170.......180.......190.......200.......210.......220.......230.......240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
Q
I
S
K
Y
K
R
V
V
L
K
LSGEALAGEKGFGI
N
P
V
I
I
K
S
V
A
E
Q
V
A
E
V
A
KMD
C
E
I
A
V
I
VGGGNIWRGKTGSDLGMDRG
T
A
-
D
Y
M
G
M
L
A
T
V
M
N
A
L
A
L
Q
D
S
L
E
QLDCD
T
R
V
L
T
S
I
E
M
K
Q
V
A
E
P
Y
I
R
R
R
A
I
R
H
L
E
KK
R
V
V
I
F
A
AGIGNPYFSTD
T
T
A
A
L
R
A
AEVEA
D
V
I
L
M
GKN-NVD
G
V
YSADPKVNK
D
A
V
K
Y
E
H
L
T
H
I
Q
M
L
Q
E
G
L
Q
V
M
D
S
T
A
S
S
FCMDNNIP
L
T
V
F
S
I
M
EEGNI
K
R
A
V
M
G
E
K
I
G
T
L
ITK
82
HHSearch
94.68
59%
-131
- C1 -
1Z9D
4
PYRH_STRP1
A:
[4-240]
---
E
P
K
Y
Q
R
I
L
I
K
L
S
G
E
A
L
A
G
E
K
G
V
G
I
D
I
P
T
V
Q
A
I
A
K
E
I
A
E
V
H
V
S
G
V
Q
I
A
L
V
I
G
G
G
N
L
W
R
G
E
P
A
A
D
A
G
M
D
R
V
Q
A
-
D
Y
T
G
M
L
G
T
V
M
N
A
L
V
M
A
D
S
L
Q
H
Y
G
V
D
T
R
V
Q
T
A
I
P
M
Q
N
V
A
E
P
Y
I
R
G
R
A
L
R
H
L
E
K
N
R
I
V
V
F
G
A
G
I
G
S
P
Y
F
S
T
D
T
T
A
A
L
R
A
A
E
I
E
A
D
A
I
L
M
A
-
K
N
G
V
D
G
V
Y
N
A
D
P
K
K
D
A
N
A
V
K
F
D
E
L
T
H
G
E
V
I
K
R
G
L
K
I
M
D
A
T
A
S
T
L
S
M
D
N
D
I
D
L
V
V
F
N
M
N
E
A
G
N
I
Q
R
V
V
F
G
E
H
I
G
T
T
V
S
N
24
PsiBlast_CBE
94.55
56%
-125
- C1 -
3NWY
3
PYRH_MYCTU
B:
[46-280]
--
Q
L
S
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
F
R
G
A
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
K
--
A
V
D
G
V
F
A
E
D
P
-----
A
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
22
PsiBlast_CBE
93.25
56%
-140
- C1 -
3NWY
2
PYRH_MYCTU
D:
[48-280]
----
S
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
----
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
K
--
A
V
D
G
V
F
A
E
D
P
R
V
N
P
E
A
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
1
PsiBlast_PDB
93.10
57%
-130
- C1 -
1Z9D
4
PYRH_STRP1
A:
[6-240]
-----
K
Y
Q
R
I
L
I
K
L
S
G
E
A
L
A
G
E
K
G
V
G
I
D
I
P
T
V
Q
A
I
A
K
E
I
A
E
V
H
V
S
G
V
Q
I
A
L
V
I
G
G
G
N
L
W
R
G
E
P
A
A
D
A
G
M
D
R
V
Q
A
-
D
Y
T
G
M
L
G
T
V
M
N
A
L
V
M
A
D
S
L
Q
H
Y
G
V
D
T
R
V
Q
T
A
I
P
M
Q
N
V
A
E
P
Y
I
R
G
R
A
L
R
H
L
E
K
N
R
I
V
V
F
G
A
G
I
G
S
P
Y
F
S
T
D
T
T
A
A
L
R
A
A
E
I
E
A
D
A
I
L
M
A
K
N
-
G
V
D
G
V
Y
N
A
D
P
K
K
D
A
N
A
V
K
F
D
E
L
T
H
G
E
V
I
K
R
G
L
K
I
M
D
A
T
A
S
T
L
S
M
D
N
D
I
D
L
V
V
F
N
M
N
E
A
G
N
I
Q
R
V
V
F
G
E
H
I
G
T
T
V
S
N
21
PsiBlast_CBE
92.70
56%
-137
- C1 -
3NWY
2
PYRH_MYCTU
F:
[49-280]
-----
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
F
R
G
A
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
K
--
A
V
D
G
V
F
A
E
D
-------
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
23
PsiBlast_CBE
90.51
56%
-133
- C1 -
3NWY
2
PYRH_MYCTU
C:
[48-280]
----
S
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
F
R
G
A
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
K
--
A
V
D
G
V
F
A
E
D
P
R
----
A
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
80
HHSearch
90.30
49%
-122
- C1 -
3EK6
-
PYRH_XANCP
A:
[1-238]
-
M
S
E
L
S
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
L
L
L
K
A
-
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
Q
G
2
PsiBlast_PDB
90.22
56%
-132
- C1 -
3NWY
2
PYRH_MYCTU
A:
[47-280]
---
L
S
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
---
A
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
K
--
A
V
D
G
V
F
A
E
-----
P
E
A
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
26
PsiBlast_CBE
90.14
50%
-119
- C1 -
3EK5
1
PYRH_XANCP
E:
[5-239]
-
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
27
PsiBlast_CBE
90.02
50%
-116
- C1 -
3EK5
1
PYRH_XANCP
D:
[5-239]
-
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
84
HHSearch
89.82
56%
-132
- C1 -
3NWY
2
PYRH_MYCTU
A:
[47-280]
---
L
S
G
Y
S
R
V
L
L
K
L
G
G
E
M
F
G
G
G
Q
-
V
G
L
D
P
D
V
V
A
Q
V
A
R
Q
I
A
D
V
V
R
G
G
V
Q
I
A
V
V
I
G
G
G
N
F
---
A
Q
L
Q
Q
L
G
M
E
R
T
R
S
-
D
Y
M
G
M
L
G
T
V
M
N
S
L
A
L
Q
D
F
L
E
K
E
G
I
V
T
R
V
Q
T
A
I
T
M
G
Q
V
A
E
P
Y
L
P
L
R
A
V
R
H
L
E
K
G
R
V
V
I
F
G
A
G
M
G
L
P
Y
F
S
T
D
T
T
A
A
Q
R
A
L
E
I
G
A
D
V
V
L
M
A
-
K
-
A
V
D
G
V
F
A
E
-----
P
E
A
E
L
L
T
A
V
S
H
R
E
V
L
D
R
G
L
R
V
A
D
A
T
A
F
S
L
C
M
D
N
G
M
P
I
L
V
F
N
L
L
T
D
G
N
I
A
R
A
V
R
G
E
K
I
G
T
L
V
T
-
28
PsiBlast_CBE
89.39
50%
-120
- C1 -
3EK5
1
PYRH_XANCP
C:
[5-239]
-
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
3
PsiBlast_PDB
89.09
50%
-120
- C1 -
3EK5
1
PYRH_XANCP
A:
[4-239]
M
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
4
PsiBlast_PDB
89.04
50%
-119
- C1 -
3EK6
-
PYRH_XANCP
A:
[1-236]
M
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
29
PsiBlast_CBE
88.92
50%
-116
- C1 -
3EK5
1
PYRH_XANCP
B:
[5-239]
-
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
5
PsiBlast_PDB
88.42
44%
-127
- C1 -
2BND
6
PYRH_ECOLI
A:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
A
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
K
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
25
PsiBlast_CBE
88.15
50%
-120
- C1 -
3EK5
1
PYRH_XANCP
F:
[5-239]
-
S
E
L
S
-
Y
R
R
I
L
L
K
L
S
G
E
A
L
M
G
D
G
D
Y
G
I
D
P
K
V
I
N
R
L
A
H
E
V
I
E
A
Q
Q
A
G
A
Q
V
A
L
V
I
G
G
G
N
I
F
R
G
A
G
L
A
A
S
G
M
D
R
V
T
G
-
D
H
M
G
M
L
A
T
V
I
N
A
L
A
M
Q
D
A
L
E
K
L
G
A
K
V
R
V
M
S
A
I
K
I
N
D
V
C
E
D
F
I
R
R
R
A
I
R
H
L
E
K
G
R
I
A
I
F
A
A
G
T
G
N
P
F
F
T
T
D
S
G
A
A
L
R
A
I
E
I
G
A
D
-
L
L
L
K
A
T
-
K
V
D
G
V
Y
D
K
D
P
K
K
H
S
D
A
V
R
Y
D
S
L
T
Y
D
E
V
I
M
Q
G
L
E
V
M
D
T
A
A
F
A
L
A
R
D
S
D
L
P
L
R
I
F
G
M
S
E
P
G
V
L
L
R
I
L
H
G
A
Q
I
G
T
L
V
--
32
PsiBlast_CBE
87.80
44%
-130
- C1 -
2V4Y
4
PYRH_ECOLI
E:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
G
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
-
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
34
PsiBlast_CBE
87.78
44%
-131
- C1 -
2V4Y
4
PYRH_ECOLI
C:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
G
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
K
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
70
Fugue
87.56
44%
-120
- C1 -
2BNE
5
PYRH_ECOLI
A:
[5-241]
--
A
K
P
V
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
G
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
T
K
--
V
D
G
V
F
T
A
D
P
P
---
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
79
HHSearch
87.45
52%
-119
* C1 *
1YBD
2
PYRH_NEIMB
A:
[4-239]
---
Q
I
K
Y
K
R
V
L
L
K
L
S
G
E
S
L
M
G
S
D
P
F
G
I
N
H
D
T
I
V
Q
T
V
G
E
I
A
E
V
V
K
M
G
V
Q
V
G
I
V
V
G
G
G
N
I
F
R
G
V
S
A
Q
A
G
S
M
D
R
A
T
A
-
D
Y
M
G
M
M
A
T
V
M
N
A
L
A
L
K
D
A
F
E
T
L
G
I
K
A
R
V
Q
S
A
L
S
M
Q
Q
I
A
E
T
Y
A
R
P
K
A
I
Q
Y
L
E
E
G
K
V
V
I
F
A
A
G
T
G
N
P
F
F
T
T
D
T
A
A
A
L
R
G
A
E
M
N
C
D
V
M
L
K
A
-
T
-
N
V
D
G
V
Y
T
A
D
P
K
K
D
P
S
A
T
R
Y
E
T
I
T
F
D
E
A
L
L
K
N
L
K
V
M
D
A
T
A
F
A
L
C
R
E
R
K
L
N
I
V
V
F
G
I
A
K
E
G
S
L
K
R
V
I
T
G
E
D
E
G
T
L
V
H
C
7
PsiBlast_PDB
86.79
44%
-125
- C1 -
2BNE
5
PYRH_ECOLI
A:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
G
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
---
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
11
PsiBlast_PDB
86.06
41%
-126
- C1 -
2BNF
6
PYRH_ECOLI
A:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
G
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
-
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
K
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
9
PsiBlast_PDB
85.43
49%
-122
- C1 -
1YBD
2
PYRH_NEIMB
A:
[6-237]
-----
K
Y
K
R
V
L
L
K
L
S
G
E
S
L
M
G
S
D
P
F
G
I
N
H
D
T
I
V
Q
T
V
G
E
I
A
E
V
V
K
M
G
V
Q
V
G
I
V
V
G
G
G
N
I
F
R
G
V
S
A
Q
A
G
S
M
D
R
A
T
A
-
D
Y
M
G
M
M
A
T
V
M
N
A
L
A
L
K
D
A
F
E
T
L
G
I
K
A
R
V
Q
S
A
L
S
M
Q
Q
I
A
E
T
Y
A
R
P
K
A
I
Q
Y
L
E
E
G
K
V
V
I
F
A
A
G
T
G
N
P
F
F
T
T
D
T
A
A
A
L
R
G
A
E
M
N
C
D
V
M
L
K
A
-
T
-
N
V
D
G
V
Y
T
A
D
P
K
K
D
P
S
A
T
R
Y
E
T
I
T
F
D
E
A
L
L
K
N
L
K
V
M
D
A
T
A
F
A
L
C
R
E
R
K
L
N
I
V
V
F
G
I
A
K
E
G
S
L
K
R
V
I
T
G
E
D
E
G
T
L
V
--
30
PsiBlast_CBE
85.22
44%
-125
- C1 -
2BND
3
PYRH_ECOLI
B:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
-
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
A
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
K
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
48
PsiBlast_CBE
84.93
47%
-132
- C1 -
4A7W
2
PYRH_HELPY
B:
[6-229]
-----
K
N
K
R
V
L
V
K
F
S
G
E
A
L
A
G
D
N
Q
F
G
I
D
I
H
V
L
D
H
I
A
K
E
I
K
S
L
V
E
N
D
I
E
V
G
I
V
I
G
G
G
N
I
I
---------
I
I
R
R
T
S
G
D
Y
M
G
M
L
A
T
V
I
N
A
V
A
M
Q
E
A
L
E
H
I
G
L
D
T
R
V
Q
S
A
I
E
I
K
E
I
C
E
S
Y
I
Y
R
K
A
I
R
H
L
E
K
G
R
V
V
I
F
G
A
G
T
G
N
P
F
F
T
T
D
T
A
A
T
L
R
A
I
E
I
G
S
D
L
I
I
K
A
-
T
-
K
V
D
G
I
Y
D
K
D
P
N
K
F
K
D
A
K
K
L
D
T
L
S
Y
N
D
A
L
I
G
D
I
E
V
M
D
D
T
A
I
S
L
A
K
D
N
K
L
P
I
V
V
C
N
M
F
K
K
G
N
L
L
Q
V
I
-----------
36
PsiBlast_CBE
84.24
44%
-120
- C1 -
2BNE
3
PYRH_ECOLI
B:
[9-241]
------
Y
K
R
I
L
L
K
L
S
G
E
A
L
Q
G
T
E
-
F
G
I
D
A
S
I
L
D
R
M
A
Q
E
I
K
E
L
V
E
L
G
I
Q
V
G
V
V
I
G
G
G
N
L
F
R
G
A
G
L
A
K
A
G
M
N
R
V
V
G
-
D
H
M
G
M
L
A
T
V
M
N
G
L
A
M
R
D
A
L
H
R
A
Y
V
N
A
R
L
M
S
A
I
P
L
N
G
V
C
D
S
Y
S
W
A
E
A
I
S
L
L
R
N
N
R
V
V
I
L
S
A
G
T
G
N
P
F
F
T
T
D
S
A
A
C
L
R
G
I
E
I
E
A
N
V
V
L
K
A
-
T
-
K
V
D
G
V
F
T
A
D
P
A
K
D
P
T
A
T
M
Y
E
Q
L
T
Y
S
E
V
L
E
K
E
L
K
V
M
D
L
A
A
F
T
L
A
R
D
H
K
L
P
I
R
V
F
N
M
N
K
P
G
A
L
R
R
V
V
M
G
E
K
E
G
T
L
I
T
E
13
PsiBlast_PDB
83.63
47%
-128
- C1 -
4A7W
2
PYRH_HELPY
A:
[6-229]
-----
K
N
K
R
V
L
V
K
F
S
G
E
A
L
A
G
D
N
Q
F
G
I
D
I
H
V
L
D
H
I
A
K
E
I
K
S
L
V
E
N
D
I
E
V
G
I
V
I
G
G
G
N
I
I
---------
I
I
R
R
T
S
G
D
Y
M
G
M
L
A
T
V
I
N
A
V
A
M
Q
E
A
L
E
H
I
G
L
D
T
R
V
Q
S
A
I
E
I
K
E
I
C
E
S
Y
I
Y
R
K
A
I
R
H
L
E
K
G
R
V
V
I
F
G
A
G
T
G
N
P
F
F
T
T
D
T
A
A
T
L
R
A
I
E
I
G
S
D
L
I
I
K
A
-
T
-
K
V
D
G
I
Y
D
K
D
P
N
K
F
K
D
A
K
K
L
D
T
L
S
Y
N
D
A
L
I
G
D
I
E
V
M
D
D
T
A
I
S
L
A
K
D
N
K
L
P
I
V
V
C
N
M
F
K
K
G
N
L
L
Q
V
I
-----------