@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1277: (2016-03-24 )
MFQLLAVCPMGLEAVVAREIQELGYETNVENGRIFFEGDASAIVKANLWLRTADRIKIVVGRFNATTFDELFEQTKALPWESIIDKEGNFPVQGRSVKSTLHSVPDCQAITKKAIVERLRRAYNEKGWLNESGAKYPVEVAILKDNVLLTIDTSGSGLNRRGYRLAQGEAPIKETLAASLIRLANWKGDTPLIDPFCGSGTIAIEACLIAQNIAPGFNREFVSEQWNIMPANIYDDYRDEADKMADYDKEIEVYASDIDPEMVEIAKRNAEEVGLSDIIKFSVKDVNTLTIDTEEPVALIGNPPYGERIGDREEVEEMYRYIGKLMKQHPFLSTYILTSNKEFEYLVNRKATKRRKLFNGYIECTYYQYWGKKTERKTIEN
Atome Classification :
(20 SA)
-.........10........20---...----.---..--.-.----.30------........-------------40...---------.....50....------....60..---------.---...---------..70--.....-------...80........90.-....-...100...--....110.......120......--.130.......140.......150...-.-...160.......170.......---180..---.....190.......200.......210.......-220........230.......240.-----.....---.250--........260.......270..-----.....280---.......--290..-.......300.......310--------------------.---------------..-----------------------.-------------------------....-320.....-..-330........340..---.---..-----..---350.......360.--......370----.........380---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
F
Q
L
L
AVCP
M
G
L
E
A
V
V
A
R
E
I
----
Q
E
L----G---YE--T-N----VEN------
G
R
I
F
F
EGD-------------A
S
A
I
V
---------
K
A
N
L
W
L
R
TA
D
R
------
I
K
I
V
V
GRF---------N---AT
T
---------
F
D
E
L
--
F
E
Q
T
K-------AL
P
W
E
S
I
IDKEGNFPV-QG
R
S
-
V
K
S
T
L
HSVP--
D
C
Q
A
I
T
K
K
A
I
V
E
R
L
R
R
A
YNEKGW--LNESGAKY
P
V
E
V
A
I
LKD
N
V
L
L
T
I
DTSG-S-GLNRRG
Y
R
LAQGEA
P
I
K
E
T
L
A
A
S
---
L
I
R
L
A---NWKGDTPLIDPFCGS
G
T
I
A
I
E
A
C
L
I
A
Q
NIAPGF
N
R
-
E
-
F
V
S
E
QWNIMP
A
N
I
Y
D
D
Y
R
D
E
A
D
K
-----
M
A
D
Y
D
---
K
E
I
---
E
V
Y
ASDI
D
P
E
M
V
E
I
A
K
R
N
A
E
EV
G
-----
L
S
D
I
I
K
F
S
---VKD
V
N
T
L
--
T
--ID-TEE
P
V
A
L
IGNPPYGERIG
D
---------------------
R
---------------
E
E
-----------------------
V
-------------------------
E
E
M
Y
-
R
Y
I
G
K
L
M
K
-QH-PF-
L
S
T
Y
I
LTSNK
E
F
E
---
Y
---
L
V
-----NR---
K
A
T
K
R
R
K
L
FN
G
Y
I
E
--
C
T
Y
Y
Q
Y
W------GKKTERKTIEN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
99.01
57%
-104
- C1 -
3K0B
2
?
A:
[14-384]
-
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
----
A
R
L
----
G
---
Y
D
--
P
-
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
-------------
L
S
A
I
A
---------
R
A
N
L
W
L
R
V
A
D
R
------
V
K
I
V
V
G
V
F
---------
K
---
A
T
T
---------
F
D
E
L
--
F
E
K
T
K
-------
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
-
A
G
K
S
-
V
K
S
T
L
Y
S
V
P
--
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
S
G
R
--
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
---
L
V
L
L
T
---
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
-----
L
A
N
Y
D
---
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
-----
L
G
D
L
I
T
F
R
---
Q
L
Q
V
A
D
F
--
Q
--
T
--
E
D
E
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
A
-----------------------
V
-------------------------
R
Q
L
Y
-
R
E
M
G
I
V
Y
K
-
R
M
-
P
T
-
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
Y
-----
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
--
T
D
L
Y
Q
Y
W
------
G
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.68
56%
-102
- C1 -
3K0B
2
?
A:
[15-384]
--
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
----
A
R
L
----
G
---
Y
D
--
P
-
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
-------------
L
S
A
I
A
---------
R
A
N
L
W
L
R
V
A
D
R
------
V
K
I
V
V
G
V
F
---------
K
---
A
T
T
---------
F
D
E
L
--
F
E
K
T
K
-------
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
-
A
G
K
S
-
V
K
S
T
L
Y
S
V
P
--
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
S
G
R
--
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
---
L
V
L
L
T
---
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
-----
L
A
N
Y
D
---
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
-----
L
G
D
L
I
T
F
R
---
Q
L
Q
V
A
D
F
--
Q
--
T
E
-
D
E
Y
G
V
-
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
A
-----------------------
V
-------------------------
R
Q
L
Y
-
R
E
M
G
I
V
Y
K
-
R
M
-
P
T
-
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
Y
-----
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
--
T
D
L
Y
Q
Y
W
------
G
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
92.06
45%
-100
- C1 -
3LDG
1
?
A:
[4-380]
-
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
----
R
N
L
----
G
---
L
D
--
C
-
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
-------------
I
E
T
I
A
---------
K
S
N
L
W
L
R
S
A
D
R
------
I
K
I
V
V
G
E
F
---------
P
---
A
R
T
---------
F
E
E
L
--
F
Q
G
V
Y
-------
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
-
A
K
A
K
S
V
K
S
K
L
H
N
E
P
--
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
S
VP
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
---
I
I
L
L
S
---
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
-----
Q
A
D
Y
D
---
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
-----
L
E
D
V
V
K
L
K
---
Q
M
R
L
Q
D
F
--
K
--
T
--
N
K
I
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
A
-----------------------
V
-------------------------
D
I
L
Y
-
N
E
M
G
E
T
F
A
-
P
L
-
K
T
-
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
F
-----
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
--
V
D
L
Y
Q
F
Y
------
G
Q
R
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.31
45%
-98
- C1 -
3LDG
1
?
A:
[5-380]
--
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
----
R
N
L
----
G
---
L
D
--
C
-
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
-------------
I
E
T
I
A
---------
K
S
N
L
W
L
R
S
A
D
R
------
I
K
I
V
V
G
E
F
---------
P
---
A
R
T
---------
F
E
E
L
--
F
Q
G
V
Y
-------
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
-
V
K
S
K
L
H
N
E
P
--
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
S
VP
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
---
I
I
L
L
S
---
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
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-
D
-
F
A
F
E
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W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
-----
Q
A
D
Y
D
---
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
-----
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
K
T
N
--
K
--
I
N
-
G
----
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
A
-----------------------
V
-------------------------
D
I
L
Y
-
N
E
M
G
E
T
F
A
-
P
L
-
K
T
-
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
F
-----
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
--
V
D
L
Y
Q
F
Y
------
G
Q
R
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.00
44%
-98
- C1 -
3LDU
12
?
A:
[7-382]
--
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
----
T
N
L
----
G
---
Y
E
--
I
I
K
----
T
E
D
------
G
R
I
T
Y
K
T
D
-------------
E
F
G
I
A
---------
K
S
N
M
W
L
R
C
A
E
R
------
V
H
L
K
I
A
E
F
---------
E
---
A
K
S
---------
F
D
E
L
--
F
E
N
T
K
-------
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
K
A
S
S
-
I
K
S
K
L
Y
S
T
P
--
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
D
G
L
--
L
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
---
L
I
Y
L
T
---
P
W
K
A
G
R
V
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
-----
K
I
D
N
E
---
S
K
F
---
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
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N
A
E
I
A
G
-----
V
D
E
Y
I
E
F
N
---
V
G
D
A
T
Q
F
--
K
--
S
E
-
D
E
F
G
F
-
I
I
T
N
P
P
Y
G
E
R
L
E
D
---------------------
K
---------------
D
S
-----------------------
V
-------------------------
K
Q
L
Y
-
K
E
L
G
Y
A
F
R
-
K
L
-
K
N
-
W
S
Y
Y
L
I
T
S
Y
E
D
F
E
---
Y
---
E
F
-----
G
Q
---
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
--
T
N
F
F
Q
Y
P
------
G
P
K
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
82.21
29%
-80
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
----
E
N
L
----
G
A--
V
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
Y
---------
Q
S
L
M
W
S
R
L
A
S
R
------
I
M
L
P
L
G
E
C
---------
K
---
V
Y
S
---------
D
L
D
L
--
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
-
H
F
S
G
-
L
N
D
T
I
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
---
I
V
M
R
S
---
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
-----
R
A
R
K
G
---
L
A
E
YS
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
-----
I
G
E
L
I
T
F
E
---
V
K
D
V
A
Q
L
--
T
NP
L
P
-
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
A
-----------------------
L
-------------------------
I
A
L
H
-
S
L
L
G
R
I
M
K
-
N
Q
-
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
-----
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
--
C
V
Q
K
N
Y
H
V
A
E
SMV
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
GIECYRLYDADLPEYN
V
A
V
D
R
Y
AD
W
V
V
V
Q
E
Y
AH
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIAPNK
L
V
L
K
T
REE
K
G
E
F
L
E
V
T
E
YN
A
H
L
W
V
N
LTDYLDTGLFLDH
R
I
A
R
R
M
L
G
Q
M
SKGKD
F
L
N
L
FSYTG
S
A
T
V
H
A
G
L
G
GAR
S
T
T
T
V
D
MS
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
GLTGRA
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
ANEQFD
L
I
F
I
D
P
P
TFSAFDVQRD
H
L
A
L
M
K
D
L
K
R
L
LRAG
G
T
I
M
F
S
N
NKRGFRMD
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
41
HHSearch
81.26
30%
-82
- C1 -
3V97
3
RLMKL_ECOLI
A:
[2-413]
-
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
----
E
N
L
----
G
---
A
V
E-
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
Y
---------
Q
S
L
M
W
S
R
L
A
S
R
------
I
M
L
P
L
G
E
C
---------
K
---
V
Y
S
---------
D
L
D
L
--
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
-
H
F
S
G
-
L
N
D
T
I
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
---
I
V
M
R
S
---
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
-----
R
A
R
K
G
L
A
E
Y
S
S
---
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
-----
I
G
E
L
I
T
F
E
---
V
K
D
V
A
Q
L
TN
P
--
L
P
-
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
A
-----------------------
L
-------------------------
I
A
L
H
-
S
L
L
G
R
I
M
K
N
Q
F
-
G
G
-
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
-----
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
--
C
V
Q
K
N
Y
H
------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.00
29%
-78
- C1 -
3V97
3
RLMKL_ECOLI
A:
[28-411]
-------------------------------------
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
Y
---------
Q
S
L
M
W
S
R
L
A
S
R
------
I
M
L
P
L
G
E
C
---------
K
---
V
Y
S
---------
D
L
D
L
--
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
-
H
F
S
G
-
L
N
D
T
I
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
---
I
V
M
R
S
---
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
---
S
H
F
-----
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
-----
I
G
E
L
I
T
F
E
---
V
K
D
V
A
Q
L
--
T
NP
L
P
-
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
A
-----------------------
L
-------------------------
I
A
L
H
-
S
L
L
G
R
I
M
K
N
Q
F
-
G
G
-
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
-----
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
--
C
V
Q
K
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
69.67
25%
-86
- C1 -
3TM4
1
?
A:
[1-370]
--
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
----
S
L
L
L
K
K
L
G
---
I
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
---------
Y
L
N
E
N
S
R
L
L
H
R
------
V
I
I
E
I
A
S
E
K
FNGIEKDE
S
---
E
E
A
---------
L
K
R
I
--
K
D
F
V
S
-------
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
-
R
S
F
R
-
K
G
D
H
N
I
T
S
I
--
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
--
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
---
M
I
E
L
A
---
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
G
---------------------------------------------------
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
-----
V
L
D
K
I
K
F
I
---
Q
G
D
A
T
Q
L
--
S
--
Q
Y
-
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
S
--
M
I
---------------------
P
---------------
D
L
-----------------------
Y
-------------------------
M
K
F
F
-
N
E
L
A
K
V
L
E
-
K
R
-----
G
V
F
I
T
T
E
K
K
A
I
E
---
E
---
A
I
-----
A
E
N
GF
E
I
I
H
H
R
V
I
G
H
G
G
L
M
--
V
H
L
Y
V
V
K
------
L
E
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
67.28
24%
-79
- C1 -
3TM4
1
?
A:
[1-365]
--
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
----
S
L
L
L
K
K
L
G
---
I
S
F
Q
I
-
E
E
KPL
G
I
E
------
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
---------
Y
L
N
E
N
S
R
L
L
H
R
------
V
I
I
E
I
A
S
E
---------
K
---
F
N
G
IEKDE
S
E
E
A
L
K
R
I
--
K
D
F
V
S
-------
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
-
R
S
F
R
-
K
G
D
H
N
I
T
S
I
--
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
--
G
T
P
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
-
D
S
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
---
M
I
E
L
A
---
E
L
-
D
G
G
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
------------------------------------------------
S
G
---
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
-----
V
L
D
K
I
K
F
I
---
Q
G
D
A
T
Q
L
--
S
--
Q
Y
-
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
M
-----------------------
I
-------------------------
P
D
L
Y
-
M
K
F
F
N
E
L
A
K
V
L
E
K
R
-
G
V
F
I
T
-
T
E
K
K
A
I
E
E
A
I
A
---
E
N
-----
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
--
V
H
L
Y
V
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
65.14
24%
-73
- C1 -
3TMA
1
?
A:
[19-352]
-
H
M
W
L
E
A
T
T
H
P
G
L
E
D
L
L
L
E
E
L
----
S
A
L
----
Y
P
G
E
G
A
E-
V
-
D
----
A
R
K
------
G
R
V
R
I
P
R
A
-------------
W
V
G
-----------
E
E
A
L
G
L
R
L
A
H
H
------
L
V
L
F
R
A
R
L
---------
L
LSR
E
D
P
---------
L
G
A
L
--
E
R
A
A
L
-------
A
L
P
W
P
E
L
E
G
-
A
G
S
F
R
V
-
E
A
R
R
-
E
G
E
H
P
F
T
S
P
--
E
V
E
R
R
V
G
E
A
L
H
R
A
Y
G
------
V
P
--
V
D
L
K
R
P
A
V
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
F
P
K
-
A
A
L
R
G
S
L
T
P
V
L
A
Q
A
---
L
L
R
L
A
---
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
-----------------------------------------------
P
T
S
---
P
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
-----
L
S
-
W
I
R
F
L
---
R
A
D
A
R
H
L
--
P
--
R
F
-
F
P
E
V
D
R
I
L
A
N
P
P
H
G
L
-------------------------
K
---------------
E
G
-----------------------
L
-------------------------
F
H
L
Y
-
W
D
F
L
R
G
A
L
A
L
L
P
P
G
-
G
R
V
A
L
L
T
L
R
P
A
L
L
---
K
R
A
L
P
P
-----
G
F
---
A
L
R
H
A
R
V
V
E
Q
G
G
V
Y
--
P
R
V
F
V
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.38
26%
-61
- C1 -
3TM5
1
?
A:
[1-336]
--
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
---
I
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
-------------
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
LLHRVI
I
E
I
A
S
E
K
F
---------
N
---
G
I
E
---------
K
D
E
S
--
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
---
M
I
E
L
A
---
E
L
D
G
G
S
V
L
-
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
I
------
E
K
Y
R
K
H
L
---------------------------
I
G
A
E
M
------
N
A
L
A
A
G
-----
V
L
D
K
I
K
F
I
---
Q
G
D
A
T
Q
L
--
S
--
Q
Y
-
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
L
K
I
G
----------------------
K
---------------
S
M
-----------------------
I
-------------------------
P
D
L
Y
M
K
F
F
N
E
L
A
K
-
V
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.56
26%
-63
- C1 -
3TM4
1
?
A:
[1-336]
--
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
---
I
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
-------------
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
LLH
R
V
I
I
E
I
A
S
E
K
F
---------
N
---
G
I
E
---------
K
D
E
S
--
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
---
M
I
E
L
A
---
E
L
D
G
G
S
V
L
-
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
I
------
E
K
Y
R
K
H
L
---------------------------
I
G
A
E
M
------
N
A
L
A
A
G
-----
V
L
D
K
I
K
F
I
---
Q
G
D
A
T
Q
L
--
S
--
Q
Y
-
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
M
-----------------------
I
-------------------------
P
D
L
Y
M
K
F
F
N
E
L
A
K
-
V
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.55
26%
-61
- C1 -
3TLJ
2
?
A:
[1-336]
--
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
---
I
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
-------------
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
LLHRVI
I
E
I
A
S
E
K
F
---------
N
---
G
I
E
---------
K
D
E
S
--
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
---
M
I
E
L
A
---
E
L
D
G
G
S
V
L
-
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
I
------
E
K
Y
R
K
H
L
---------------------------
I
G
A
E
M
------
N
A
L
A
A
G
-----
V
L
D
K
I
K
F
I
---
Q
G
D
A
T
Q
L
--
S
--
Q
Y
-
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
M
-----------------------
I
-------------------------
P
D
L
Y
M
K
F
F
N
E
L
A
K
-
V
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.02
25%
-67
- C1 -
3TMA
1
?
A:
[46-296]
--------------------------------
G
---
A
E
--
V
-
D
----
A
R
K
------
G
R
V
R
I
--
P
-------------
R
A
W
V
G
---------
E
E
A
L
G
L
R
L
A
H
H
------
L
V
L
F
R
A
R
L
---------
L
---
L
S
R
---------
E
D
P
L
G
A
L
E
R
A
A
L
------
A
L
P
W
P
E
L
-
E
G
A
G
S
F
R
V
-
E
A
R
R
-
E
G
E
H
P
F
T
S
P
--
E
V
E
----
R
R
V
G
E
A
L
H
R
A
Y
G
V
P
V
D
--
L
K
R
P
A
V
R
--
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
-
F
P
K
A
A
L
R
G
S
L
T
P
V
L
A
Q
A
---
L
L
R
L
A
---
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
P
T
S
P
--------------------------------------------------
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
-----
L
S
-
W
I
R
F
L
---
R
A
D
A
R
H
L
--
P
--
R
F
-
F
P
E
V
D
R
I
L
A
N
P
P
H
G
L
-------------------------
K
---------------
E
G
-----------------------
L
-------------------------
F
H
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
51.45
23%
-75
- C1 -
1NV8
2
PRMC_THEMA
A:
[104-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
P
E
T
E
E
L
V
E
L
---
A
L
E
L
I
---
R
K
Y
G
I
K
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-------------------------------------------------
D
A
---
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
G
-----
V
S
D
R
F
F
V
R
---
K
G
E
F
L
E
P
--
F
--
K
E
K
F
A
S
I
E
M
I
L
S
N
P
P
Y
V
K
S
S
A
H
---------------------
L
PKDVLFEPPEALFGG
E
D
-----------------------
G
-------------------------
L
D
F
Y
-
R
E
F
F
G
R
Y
D
----
T
S
-
G
K
I
V
L
M
E
I
G
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
48.44
18%
-77
- C1 -
2B3T
1
PRMC_ECOLI
A:
[96-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
L
V
E
Q
---
A
L
A
R
L
---
P
-
E
Q
P
C
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
------------------------------------------------
D
C
---
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
A
-----
I
K
-
N
I
H
I
L
---
Q
S
D
W
F
S
A
--
L
---
A
-
G
Q
Q
F
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
H
L
Q
Q
GDVRFEPLTALVAADSG
M
---------------
A
D
-----------------------
I
-------------------------
V
H
I
I
-
E
Q
S
R
N
A
L
V
----
S
G
-
G
F
L
L
L
E
H
G
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
48.10
22%
-62
- C1 -
3GDH
3
TGS1_HUMAN
B:
[25-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
A
V
P
E
L
A
K
Y
W
A
Q
R
Y
R
L
F
S
R
F
D
D
G
-
I
-
K
L
D
R
E
G
W
F
S
V
-----
T
P
E
K
I
A
E
H
---
I
A
G
R
V
---
S
-
Q
S
C
D
V
V
V
D
A
F
C
G
V
G
G
N
T
I
Q
F
A
L
T
G
M
-----------------------------------------------------
R
V
I
A
I
D
I
D
P
V
K
I
A
L
A
R
N
N
A
E
V
Y
G
-----
I
A
D
K
I
E
F
I
---
C
G
D
F
L
L
L
--
A
--
S
F
-
L
K
A
D
V
V
F
L
S
P
P
W
G
G
P
D
Y
A
T
---------------------
A
---------------
E
T
FDIRTMMSPD-------------
G
-------------------------
F
E
I
F
-
R
L
S
K
K
I
T
N
-
N
------
I
V
Y
F
L
P
R
N
A
D
I
D
---
Q
---
V
A
S
L
AGP
G
G
---
Q
V
E
I
E
Q
N
F
L
N
N
K
L
K
T
I
T
A
Y
F
G
D
L
------
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
47.56
16%
-65
- C1 -
3KHK
1
?
A:
[228-401]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
P
K
S
I
V
T
L
---
I
V
E
M
L
---
E
P
Y
K
-
G
R
V
Y
D
P
A
M
G
S
G
G
F
F
V
S
S
D
K
F
I
E
K
H
A
N
V
K
-----------------
H
Y
N
A
-------------
S
E
Q
K
---
K
Q
I
---
S
V
Y
G
Q
E
S
N
P
T
T
W
K
L
A
A
M
N
M
V
I
R
G
-----
I
D
F
N
F
G
K
K
---
N
A
D
S
F
L
D
--
D
Q-
H
P
-
D
L
R
A
D
F
V
M
T
N
P
P
F
N
M
K
D
W
W
---------------------
H
---------------
E
K
LADDPRW
T
I
N
T
NKRILTPPTGNA
N
-------------------------
F
A
W
M
-
L
H
M
L
Y
H
L
A
----
P
T
-
G
S
M
A
L
L
L
A
N
G
S
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
47.14
16%
-73
- C1 -
3S1S
11
?
A:
[301-471]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
K
V
L
S
I
I
S
Q
H
I
L
G
R
P
L
T
E
D
E
V
I
S
D
P
A
A
G
S
G
N
L
L
A
T
V
S
A
G
F
N
N
V
---------------------------------------------
M
P
R
---
Q
I
W
A
N
D
I
E
T
L
F
L
E
L
L
S
I
R
L
G
L
L
F
PQLVS
S
N
N
A
P
T
I
T
---
G
E
D
V
C
S
L
--
N
--
P
E
D
F
A
N
V
S
V
V
V
M
N
P
P
Y
V
S
G
V
T
D
---------------------
P
---------------
A
I
-----------------------
K
R
K
F
A
H
K
I
I
Q
L
TGNRPQTLFGQIG
V
E
A
L
F
L
-
E
L
V
T
E
L
V
Q
----
D
G
-
T
V
I
S
A
I
M
P
K
Q
Y
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------