@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0166: (2015-12-13 )
MLQRPKIVAELSANHNQDLNLAKESLHAIKESGADFVKLQTYTPSCMTLDSKEDPFIIQGTLWDKENLYGLYQKASTPLEWHAELFELAKKLDLGIFSSPFSSKALELLESLDCPMYKIASFEIVDLDLIEKAARTQKPIILSSGIATHAELQDAISLCRGVNNFDITLLKCVSAYPSKIEDAHLLSMVKLGETFGVKFGLSDHTIGSLCPILATTLGASMIEKHFILNKSLQTPDSAFSMDFNGFKSMVGAIKQSVLALGEEEPKINPKTLEERRFFARSLFVIKDIQKGEALTSDNIKALRPNLGLHPKFYKEILGQKASKFLKANTPLSADDIERAL
Atome Classification :
(20 SA)
.........10......--..20---.........30.--...---.---...40.-.......50........60........70.......-.--80........90........100....-...110.......120.......130.......140...-.-.-..150------------.....--..-160----.--......170.--.--....-..180.......190...-.-...200....-----..-----.-----.210---.-.......--220.........230.......240---.........250.......260-..-..-------------...270------------.......280.......290.......300....---.---.-..310.....--..320....--...330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLQRP
K
I
V
A
E
LSANHNQ--
D
L
N
----
L
A
K
E
S
L
H
A
I
K
ES--GA
D
---
F
---
V
K
L
Q
TY-TPS
C
M
TLDSKED
P
F
I
I
Q
G
TLWDK
E
N
L
Y
G
L
Y
Q
KAST
P
-
L
--
E
W
H
A
E
L
F
E
L
A
K
K
LDLGIFSSP
F
S
S
K
A
L
-
E
L
L
E
SLDCP
M
Y
K
I
A
S
F
E
I
V
D
L
D
L
I
E
K
A
ARTQK
P
I
I
LSSG-I-A-
T
H
A
E
L
------------
Q
D
A
I
S
--
L
C
-RGV----N--NF
D
I
T
L
L
K
-
C
--
V
--
S
AYP-SKI
E
D
A
H
L
L
S
M
V
K
LGE
T
F
-
G
-
V
K
FGL-SDH
T
-----
I
G
-----
S
-----
L
C
-
P
---
I
-
L
A
T
T
L
G
A
--
S
--
M
I
E
K
H
F
I
LNKSLQTPDSAFS-----M
D
F
N
G
F
K
S
M
V
G
A
I
K
Q
S
V
L
A
LGE-EE-PK-------------I
N
P
K
T
L
------------
E
E
R
R
F
F
A
R
S
L
F
V
I
KDIQKGEALTSDN
I
K
-ALRPN---L---G-L
H
P
K
F
Y
K
E
I
L
--
G
Q
K
A
S
K
F
L
K--ANTPL
S
A
D
D
I
E
RAL
2
PsiBlast_PDB
95.40
30%
-87
- C5 -
1XUU
2
?
A:
[18-349]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
4
PsiBlast_PDB
94.95
30%
-87
- C5 -
2ZDR
2
?
A:
[18-349]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
6
PsiBlast_PDB
94.86
29%
-87
- C5 -
4IPJ
2
?
A:
[20-351]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
K
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
3
PsiBlast_PDB
94.85
30%
-85
- C5 -
1XUZ
3
?
A:
[18-349]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
1
PsiBlast_PDB
94.82
31%
-84
- C5 -
1VLI
1
SPSE_BACSU
A:
[31-376]
------
I
I
A
E
A
G
I
N
H
D
G
--
K
L
D
----
Q
A
F
A
L
I
D
A
A
A
E
A
--
G
A
D
---
A
---
V
K
F
Q
M
F
-
Q
---
A
D
R
M
Y
Q
K
D
P
---------
D
V
S
I
F
S
L
V
Q
S
M
E
M
P
-
A
--
E
W
I
L
P
L
L
D
Y
C
R
E
K
Q
V
I
F
L
S
T
V
C
D
E
G
S
A
-
D
L
L
Q
S
T
S
P
S
A
F
K
I
A
S
Y
E
I
N
H
L
P
L
L
K
Y
V
A
R
L
N
R
P
M
I
F
S
T
A
-
G
-
A
-
E
I
S
D
V
------------
H
E
A
W
R
--
T
I
-
R
A
E
----
G
--
N
N
Q
I
A
I
M
H
-
C
--
V
--
A
K
Y
P
-
A
P
P
E
Y
S
N
L
S
V
I
P
M
L
A
A
A
F
-
P
E
A
V
I
G
F
-
S
D
H
S
E----
H
P
-----
T
-----
E
A
-
P
---
C
-
A
A
V
R
L
G
A
--
K
--
L
I
E
K
H
F
T
I
D
K
N
L
P
G
A
D
H
S
F
A
-----
L
N
P
D
E
L
K
E
M
V
D
G
I
R
K
T
E
A
E
L
K
Q
-
G
I
-
T
K
P
------------
V
S
E
K
L
L
GSSY
K
T
T
T
AIEG
E
I
R
N
F
A
Y
R
G
I
F
T
T
A
P
I
Q
K
G
E
A
F
S
E
D
N
I
A
-
V
L
R
P
G
QKP
Q
---
G
-
L
H
P
R
F
F
-
E
L
L
T
S
G
V
R
A
V
R
D
I
P
--
A
D
T
G
I
V
W
D
D
I
L
L
K
D
5
PsiBlast_PDB
94.79
30%
-89
- C5 -
3CM4
1
?
A:
[18-349]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
7
PsiBlast_PDB
94.70
29%
-88
- C5 -
4IPI
3
?
A:
[20-351]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
I
V
E
D
E
M
S
D
E
A
K
Q
---
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
A
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
17
HHSearch
94.24
32%
-76
- C5 -
1VLI
1
SPSE_BACSU
A:
[26-379]
-
D
A
P
V
F
I
I
A
E
A
G
I
N
H
D
G
--
K
L
D
----
Q
A
F
A
L
I
D
A
A
A
E
A
--
G
A
D
---
A
---
V
K
F
Q
M
F
-
Q
A
D
R
M
Y
Q
K
D
P
------------
D
V
S
I
F
S
L
V
Q
S
M
E
M
P
-
A
--
E
W
I
L
P
L
L
D
Y
C
R
E
K
Q
V
I
F
L
S
T
V
C
D
E
G
S
A
-
D
L
L
Q
S
T
S
P
S
A
F
K
I
A
S
Y
E
I
N
H
L
P
L
L
K
Y
V
A
R
L
N
R
P
M
I
F
S
T
A
-
G
-
A
-
E
I
S
D
V
------------
H
E
A
W
R
--
T
I
-
R
A
E
----
G
--
N
N
Q
I
A
I
M
H
-
C
--
V
--
A
K
Y
P
-
A
P
P
E
Y
S
N
L
S
V
I
P
M
L
A
A
A
F
P
E
-
A
V
I
G
F
-
S
D
H
S
-----
E
H
P----
T
-----
E
A
-
P
---
C
-
A
A
V
R
L
G
A
--
K
--
L
I
E
K
H
F
T
I
D
K
N
L
P
G
A
D
H
S
F
A
-----
L
N
P
D
E
L
K
E
M
V
D
G
I
R
K
T
E
A
E
L
K
Q
-
G
I
-
T
K
P
V
S
EKLLGSSY
K
T
T
T
A
I
E
G
------------
E
I
R
N
F
A
Y
R
G
I
F
T
T
A
P
I
Q
K
G
E
A
F
S
E
D
N
I
A
-
V
L
R
P
G
---
Q
KPQ
G
-
L
H
P
R
F
F
E
L
L
T
S-
G
V
R
A
V
R
D
I
P
--
A
D
T
G
I
V
W
D
D
I
L
L
K
D
8
PsiBlast_PDB
93.91
29%
-84
- C5 -
2WQP
8
?
A:
[18-349]
--
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
-
I
--
V
E
D
E
M
S
D
E
A
K
Q
V
I
P
G
N
A
--
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
L
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
---
V
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
16
HHSearch
93.77
30%
-79
- C5 -
2WQP
8
?
A:
[17-349]
-
N
H
E
P
L
I
I
C
E
I
G
I
N
H
E
G
--
S
L
K
----
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
E
---
V
---
V
K
H
Q
T
H
-
I
V
E
D
E
M
S
D
E
A
K
Q
V
I
--
P
G
N
--
A
D
V
S
I
Y
E
I
M
E
R
C
A
L
N
-
E
--
E
D
E
I
K
L
K
E
Y
V
E
S
K
G
M
I
F
I
S
T
L
F
S
R
A
A
A
-
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
I
I
L
S
T
G
-
M
-
N
-
S
I
E
S
I
------------
K
K
S
V
E
--
I
I
-
R
E
A
----
G
--
V
-
P
Y
A
L
L
H
-
C
--
T
--
N
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
D
L
S
E
A
F
P
D
-
A
I
I
G
L
-
S
D
H
T
-----
L
D
-----
N
-----
Y
A
-
C
---
L
-
G
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
-----
M
N
P
D
T
F
K
E
L
K
Q
G
A
H
A
L
K
L
A
R
G
G
-
K
K
-
D
T
-------------
I
I
A
G
E
K
------------
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
-
V
K
R
P
G
---
N
---
G
D
F
S
V
N
E
Y
E
T
L
F
--
G
K
V
A
A
C
N
I
R
--
K
G
A
Q
I
K
K
T
D
I
E
---
9
PsiBlast_PDB
84.47
26%
-85
- C5 -
3G8R
1
?
A:
[5-327]
---
K
P
L
F
I
F
E
M
A
N
N
H
M
G
--
N
V
E
----
H
G
V
A
L
I
R
A
I
R
E
S
C
Q
G
F
D
---
F
D
F
G
F
K
L
Q
Y
------
R
N
L
D
T
-----
F
I
H
S
S
F
K
G
R
D
D
V
K
Y
V
K
R
F
E
E
T
R
-
L
Q
P
E
Q
M
Q
K
L
V
A
E
M
K
A
N
G
F
K
A
I
C
T
P
F
D
E
E
S
V
-
D
L
I
E
A
H
G
I
E
I
I
K
I
A
S
C
S
F
T
D
W
P
L
L
E
R
I
A
R
S
D
K
P
V
V
A
S
T
A
-
G
-
A
-
R
R
E
D
I
------------
D
K
V
V
S
F
M
L
H
-
R
G
K
---------
D
L
T
I
M
H
-
C
--
V
--
A
E
Y
P
-
T
P
D
D
H
L
H
L
A
R
I
K
T
L
R
Q
Q
Y
A
G
-
V
R
I
G
Y
-
S
T
H
E
-----
D
P
-----
D
-----
L
M
E
P
---
I
M
L
A
V
A
Q
G
A
--
T
--
V
F
E
K
H
V
G
L
-
P
T
D
Q
Y
G
I
N
N
Y
S
-----
A
N
P
E
Q
V
R
R
W
L
A
A
A
A
R
A
L
A
M
L
G
D
G
E
D
-
D
A
-------------
V
S
E
T
E
Q
------------
A
S
L
R
S
L
R
R
G
V
F
A
T
R
P
V
A
A
G
E
A
L
T
A
D
N
V
S
F
A
F
P
P
V
---
E
---
G
--------
Q
L
T
--
A
N
E
W
S
K
Y
V
R
YT
A
K
T
P
I
A
A
D
A
P
V
M
A
A
15
HHSearch
84.21
25%
-81
- C5 -
3G8R
1
?
A:
[5-341]
---
K
P
L
F
I
F
E
M
A
N
N
H
M
G
--
N
V
E
----
H
G
V
A
L
I
R
A
I
R
E
S
C
Q
G
F
D
F
D
F
G
---
F
K
L
Q
Y
R
-
N
L
D
T
F
I
H
S
S
F
K
G
R
--------
D
D
V
K
Y
V
K
R
F
E
E
T
R
L
Q
-
P
--
E
Q
M
Q
K
L
V
A
E
M
K
A
N
G
F
K
A
I
C
T
P
F
D
E
E
S
V
-
D
L
I
E
A
H
G
I
E
I
I
K
I
A
S
C
S
F
T
D
W
P
L
L
E
R
I
A
R
S
D
K
P
V
V
A
S
T
A
-
G
-
A
-
R
R
E
D
I
------------
D
K
V
V
S
--
F
M
-
L
H
R
----
G
---
K
D
L
T
I
M
H
-
C
--
V
--
A
E
Y
P
-
T
P
D
D
H
L
H
L
A
R
I
K
T
L
R
Q
Q
Y
A
G
-
V
R
I
G
Y
-
S
T
H
E
-----
D
P
DL---
M
-----
E
P
-
I
---
M
-
L
A
V
A
Q
G
A
--
T
--
V
F
E
K
H
V
G
L
P
T
D
Q
Y
G
I
N
-
N
Y
S
-----
A
N
P
E
Q
V
R
R
W
L
A
A
A
A
R
A
L
A
M
L
G
D
-
G
E
D
D
A
-------------
V
S
E
T
E
Q
------------
A
S
L
R
S
L
R
R
G
V
F
A
T
R
P
V
A
A
G
E
A
L
T
A
D
N
V
S
-
F
A
F
P
P
---
V
EG-
Q
-
L
T
A
N
E
W
S
K
Y
V
--
R
Y
T
A
K
T
P
I
A
--
A
D
A
P
V
M
A
A
D
L
E
P
V
-
21
HHSearch
65.71
19%
-84
- C5 -
1VS1
2
?
A:
[37-275]
--
G
S
K
A
V
I
A
--
G
P
C
S
V
E
--
S
W
E
----
Q
V
R
E
A
A
L
A
V
K
E
A
--
G
A
H
---
M
---
L
R
G
G
A
F
-
K
P
R
T
S
--
P
----
Y
-----------
S
----
F
--
Q
G
L
G
-
L
--
E
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
-
E
T
V
S
R
Y
-
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
-
F
G
N
-
T
V
E
E
L
------------
L
A
A
A
E
--
Y
I
-
L
L
E
----
G
--
N
W
Q
V
V
L
V
E
-
R
--
G
I
R
T
F
E
P
-
S
T
R
F
T
L
D
V
A
A
V
A
V
L
K
E
A
T
-
H
-
L
P
V
I
V
D
P
S
H
P
-----
A
G
-----
R
RS---
L
V
-
P
A
L
A
K
-
A
G
L
A
A
G
A
D
G
L
--
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
-----
L
T
P
G
E
F
A
R
L
M
G
E
L
R
W
H
R
L
L
------------------------------------------------------------------------------------------------------------------------
22
HHSearch
65.09
20%
-77
- C5 -
3NVT
2
?
A:
[141-380]
--
G
E
P
V
F
V
F
--
G
P
C
S
V
E
--
S
Y
E
----
Q
V
A
A
V
A
E
S
I
K
A
K
--
G
L
K
---
L
---
I
R
G
G
A
F
-
K
P
R
T
S
--
P
Y
---------------
D
F
----
Q
--
G
L
G
-
L
--
E
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
-
E
V
A
L
D
Y
-
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
-
L
S
A
-
T
I
E
E
F
------------
I
G
A
A
E
--
Y
I
-
M
S
Q
----
G
--
N
G
K
I
I
L
C
E
R
G
--
I
--
R
T
Y
E
K
A
T
R
N
T
L
D
I
S
A
V
P
I
L
K
K
E
T
-
H
-
L
P
V
M
V
D
V
T
H
S
-----
T
G
-----
R
KDL
L
L
P
C
-
A
---
K
-
A
A
L
A
I
E
A
--
D
--
G
V
M
A
E
V
H
P
D
P
A
V
A
L
S
D
S
A
Q
Q
-----
M
D
I
P
E
F
E
E
F
W
N
A
I
L
A
S
N
L
V
P
-----------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.29
20%
-72
* C5 *
1VR6
-
AROF_THEMA
A:
[94-337]
---
Y
F
T
I
I
A
--
G
P
C
S
V
E
--
G
R
E
----
M
L
M
E
T
A
H
F
L
S
E
L
--
G
V
K
---
V
---
L
R
G
G
A
Y
-
K
P
R
T
--
S
P
----
Y
-----------------
S
F
Q
G
L
G
-
E
--
K
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
-
P
K
V
A
E
Y
-
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
-
N
-
T
I
E
E
F
------------
L
L
S
A
E
--
Y
I
-
A
N
S
----
G
--
N
T
K
I
I
L
C
E
-
R
G
-
I
R-
T
F
E
K
-
A
T
R
N
T
L
D
I
S
A
V
P
I
I
R
K
E
S
-
H
-
L
P
I
L
V
D
P
S
H
S
-----
G
G
RRDL
V
I
-----
P
L
-
S
---
R
-
A
A
I
A
V
G
A
--
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
-----
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
A
D
A
L
G
V
-
K
V
-
N
----------------------------------------------------------------------------------------------------------------
18
HHSearch
61.11
13%
-74
- C5 -
3SZ8
1
?
A:
[18-280]
-
S
L
P
F
V
L
F
G
G
I
N
V
L
E
S
L
D
F
T
L
D
----
V
C
G
E
Y
V
A
V
T
R
K
L
--
G
I
P
---
F
---
V
F
K
A
S
F
-
D
K
A
N
R
S
S
I
H
S
Y
-------------------
R
--
G
V
G
L
D
--
E
G
L
K
I
F
A
E
V
K
A
R
F
G
V
P
V
I
T
D
V
H
E
A
E
Q
A
-
A
P
V
A
E
I
-
A
D
V
L
Q
V
P
A
F
L
A
R
Q
T
D
L
V
V
A
I
A
K
A
G
K
P
V
N
V
K
K
P
-
Q
-
F
M
S
P
T
Q
L
------------
K
H
V
V
S
--
K
C
-
G
E
V
----
G
--
N
D
R
V
M
L
C
E
-
R
--
G
--
S
S
F
G
-
Y
D
N
L
V
V
D
M
L
G
F
R
Q
M
A
E
T
T
G
G
-
C
P
V
I
F
D
V
T
H
S
LQ-----------
V
L
---
D
L
-
A
---
R
-
A
G
I
A
V
G
I
--
A
G
L
F
L
E
A
H
P
D
P
D
R
A
R
--
C
D
G
P
S
A
-----
L
P
L
H
Q
L
E
G
L
L
S
Q
M
K
A
I
D
D
L
V
K
R
-
M
P
-
A
L
---------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.78
22%
-76
- C5 -
1VR6
-
AROF_THEMA
A:
[112-334]
-----------------------------
E
T
A
H
F
L
S
E
L
--
G
V
K
---
V
---
L
R
G
G
A
Y
-
K
P
-------
R
T
S
P
Y
S
F
Q
G
----------
L
G
E
K
G
----
L
--
E
Y
---
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
--
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
-
F
-
M
-
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
--
L
C
E
R
G
I
----
R
--
T
F
E
K
A
T
R
N
-
T
LD
I
--
S
A
V
P
-
I
I
R
K
E
S
H
L
P
I
L
V
D
--------------
P
S
H
S
-----
G
G
-----
R
-----
R
D
-
L
---
V
-
I
P
L
S
R
A
A
--
I
--
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
S
DGKQS
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
A
D
A
L
G
V
-
K
V
-
N
----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.40
22%
-75
- C5 -
3PG9
3
AROF_THEMA
A:
[112-334]
-----------------------------
E
T
A
H
F
L
S
E
L
--
G
V
K
---
V
---
L
R
G
G
A
Y
-
K
P
-------
R
T
S
P
Y
S
F
Q
G
----------
L
G
E
K
G
----
L
--
E
Y
---
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
--
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
-
F
-
M
-
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
--
L
C
E
R
G
I
----
R
--
T
F
E
K
A
T
R
N
-
T
LD
I
--
S
A
V
P
-
I
I
R
K
E
S
H
L
P
I
L
V
D
--------------
P
S
H
S
-----
G
G
-----
R
-----
R
D
-
L
---
V
-
I
P
L
S
R
A
A
--
I
--
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
S
DGKQS
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
A
D
A
L
G
V
-
K
V
-
N
----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.26
22%
-75
- C5 -
1RZM
3
AROF_THEMA
A:
[112-334]
-----------------------------
E
T
A
H
F
L
S
E
L
--
G
V
K
---
V
---
L
R
G
G
A
Y
-
K
P
-------
R
T
S
P
Y
S
F
Q
G
----------
L
G
E
K
G
----
L
--
E
Y
---
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
--
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
-
F
-
M
-
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
--
L
C
E
R
G
I
----
R
--
T
F
E
K
A
T
R
N
-
T
LD
I
--
S
A
V
P
-
I
I
R
K
E
S
H
L
P
I
L
V
D
--------------
P
S
H
S
-----
G
G
-----
R
-----
R
D
-
L
---
V
-
I
P
L
S
R
A
A
--
I
--
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
S
DGKQS
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
A
D
A
L
G
V
-
K
V
-
N
----------------------------------------------------------------------------------------------------------------
24
HHSearch
58.73
14%
-90
- C5 -
3TML
3
KDSA_BURCJ
A:
[15-281]
-
D
Q
P
F
F
L
I
A
--
G
T
C
V
V
E
--
S
E
Q
M
T
I
D
T
A
G
R
L
K
E
I
C
E
K
L
--
N
V
P
---
F
---
I
Y
K
S
S
Y
------------------------------------
G
M
D
--
E
G
L
R
I
L
S
E
V
K
R
Q
L
G
L
P
V
L
T
D
V
H
S
I
D
E
I
-
E
Q
V
A
S
V
-
V
D
V
L
Q
T
P
A
F
L
C
R
Q
T
D
F
I
H
A
C
A
R
S
G
K
P
V
N
I
K
K
G
-
Q
F
L
-
A
P
H
D
M
------------
K
N
V
I
D
--
K
A
-
R
D
A
A
R
E
A
G
LS
E
D
R
F
M
A
C
E
-
R
--
G
--
V
S
F
G
-
Y
N
N
L
V
S
D
M
R
S
L
A
I
M
R
-
E
T
-
N
-
A
P
V
V
F
D
A
T
H
S
VQLPG-------
Q
REF
V
P
V
L
-
A
---
R
-
A
A
V
A
T
G
V
--
A
G
L
F
M
E
T
H
P
N
P
A
E
A
K
--
S
D
G
P
N
A
-----
V
P
L
N
R
M
G
A
L
L
E
T
L
V
T
L
D
Q
A
V
K
R
-
N
P
-
F
L
-------------
E
N
D
F
----------------------------------------------------------------------------------------------