@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0248: (2015-12-13 )
MKPYFSLEKLDLYHGDASVLETFEKGFYDLCVTSPPYNLSIEYQGSNDFRAYDDYLNWCKNWLKNCYFWGKEQARLCLNVPLDTNKHGKQSLGADITIVAKECGWKYQNTIIWNESNISRRTAWGSWLQASAPYAIAPVELIVVFYKNEYKRKKQTSTMSREEFLLYTNGLWNFSGESKKRLKHPAPFPRELPRRCIQLFSFLEDTIFDPFSGSGTTILEANALGRFSVGLEIEKEYCELSKKRILESLSLV
Atome Classification :
(20 SA)
---.........10......-..20........30........40-......-------..---.50.......--.60.......-.70........80..-....--.--.---90--.---.-.......100.......110.....-------..120-....----..-.130..---.....140...-------....----150..-----.--------.--..-----------------.160-........170---...-..-----...-----------.--180.------......190.......200........210-.........220...----------------------------------------...---.230..------------.....240.......250------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MKPYFSL
E
K
L
D
LYHG
D
A
-
S
V
L
E
T
F
E
KGF
Y
D
L
CVTSPP
Y
N
L
S
--
I
E
Y
QGS-------ND---F
R
A
Y
D
D
Y
L
N
W
--
C
K
N
W
L
K
NCYF-WGKE
Q
A
R
L
C
L
NVPLD-TNKH--G--
K
---
Q
---S---L-GA
D
I
T
I
V
A
KECG
W
K
YQ
N
T
I
I
WNESN-------ISRR
T
-
A
W
G
S
----
W
L
-QASAP
Y
---
A
IA
P
V
E
L
I
V
V
F
-------YK
N
E
----
Y
K
R
K
K-----Q--------T--ST-----------------MSR--
E
E
F
L
L
Y
TNG-----LWN-FS-----GES-----------K--KRLK------HPAPF
P
R
E
L
P
R
R
C
I
Q
L
F
S
-
F
L
E
D
TIFDP---FSGSG
T
T
I
L
E
ANALG----------------------------------------
R
F
S
---VG
L
E
I
E
------------
K
E
Y
C
E
L
S
K
K
R
I
L
E
S
LSLV------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.24
29%
-72
- C5 -
2ZIF
1
?
A:
[24-276]
--------------
L
H
V
G
D
A
R
E
V
L
A
S
F
P
E
A
S
V
H
L
V
V
T
S
P
P
Y
W
T
L
--------PGQL
G
H
I
E
D
---
Y
E
A
F
L
D
E
L
D
R
--
V
W
R
E
V
F
R
L
L
V
-
P
G
G
R
L
V
I
V
V
G
D
V
A
V
A
-
R
--
F
--
G
--
R
---
H
L
V
F
P
---
L
-
H
A
D
I
Q
V
R
C
R
K
L
G
F
D
N
L
N
P
I
I
W
H
K
H
T
-------
N
--------------------
P
Y
EPG
A
I
I
K
T
E
I
E
Y
I
L
M
Q
R
K
P
G
G
Y
R
K
P
----
T
Q
E
Q
R
-----
E
--------
K
--
S
R
-----------------
L
P
K
--
E
D
F
H
R
F
F
R
Q
-----
I
W
D
D
I
P
-----------------------------------
P
F
P
L
E
L
A
E
R
L
V
R
M
F
S
-
F
V
G
D
V
V
L
D
P
---
F
A
G
T
G
T
T
L
I
A
A
A
R
W
G
----------------------------------------
R
R
A
---
L
G
V
E
L
V
------------
P
R
Y
A
Q
L
A
K
E
R
F
A
R
E
V
P
G
F
------------------------------------------------------------------------------------------------
25
HHSearch
90.28
29%
-87
- C5 -
2ZIG
-
?
A:
[21-281]
-----------
V
H
R
L
H
V
G
D
A
R
E
V
L
A
S
F
P
E
A
S
V
H
L
V
V
T
S
P
P
Y
W
T
L
--
K
-------------
Q
L
G
H
I
E
D
Y
E
A
F
L
D
E
--
L
D
R
V
W
R
E
V
F
R
-
L
L
V
P
G
G
R
L
V
I
V
V
G
D
V
-
A
V
A
R
--
R
---
H
L
V
F
---
P
---
L
-
H
A
D
I
Q
V
R
C
R
K
L
G
F
D
N
L
N
P
I
I
W
H
K
H
------------------------P
Y
E
P
G
A
I
---
I
K
T
E
I
E
Y
I
L
M
Q
-------
R
K
P
G
----
G
Y
R
K
P
-----
T
Q
E
Q
R
E
---
K
--
S
R
-----------------
L
P
K
--
E
D
F
H
R
F
F
R
Q
-----
I
W
D
-
D
I
-----
P
----------------------------
A
P
F
P
L
E
L
A
E
R
L
V
R
M
F
S
-
F
V
G
D
V
V
L
D
P
---
F
A
G
T
G
T
T
L
I
A
A
A
R
W
G
----------------------------------------
R
R
A
---
L
G
V
E
L
V
------------
P
R
Y
A
Q
L
A
K
E
R
F
A
R
E
V
P
G
F
------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.43
29%
-75
- C5 -
2ZIG
-
?
A:
[24-276]
--------------
L
H
V
G
D
A
R
E
V
L
A
S
F
P
E
A
S
V
H
L
V
V
T
S
P
P
Y
W
T
L
--
K
-----QL
G
H
I
--
E
D
---
Y
E
A
F
L
D
E
L
D
R
--
V
W
R
E
V
F
R
L
L
V
-
P
G
G
R
L
V
I
V
V
G
D
V
A
V
A
-
R
--------
R
---
H
L
V
F
P
---
L
-
H
A
D
I
Q
V
R
C
R
K
L
G
F
D
N
L
N
P
I
I
W
H
K
H
-----------------------------
P
Y
EPG
A
I
I
K
T
E
I
E
Y
I
L
M
Q
R
K
P
G
G
Y
R
K
P
----
T
Q
E
Q
R
-----
E
--------
K
--
S
R
-----------------
L
P
K
--
E
D
F
H
R
F
F
R
Q
-----
I
W
D
D
I
P
----------------------------------
A
P
F
P
L
E
L
A
E
R
L
V
R
M
F
S
-
F
V
G
D
V
V
L
D
P
---
F
A
G
T
G
T
T
L
I
A
A
A
R
W
G
----------------------------------------
R
R
A
---
L
G
V
E
L
V
------------
P
R
Y
A
Q
L
A
K
E
R
F
A
R
E
V
P
G
F
------------------------------------------------------------------------------------------------
27
HHSearch
85.85
22%
-76
- C5 -
1BOO
1
MTP2_PROHU
A:
[8-298]
-----
P
A
Y
T
T
S
N
G
S
M
Y
I
G
D
S
L
E
L
L
E
S
F
P
E
E
S
I
S
L
V
M
T
S
P
P
F
A
L
Q
--
R
K
K
E
Y
G
------------
N
L
E
Q
H
E
Y
V
D
W
--
F
L
S
F
A
K
V
V
N
K
-
K
L
K
P
D
G
S
F
V
V
D
F
G
G
A
-
Y
M
K
G
--
V
PA
R
---
S
---
I
---
Y
N
F
R
V
L
I
R
M
I
D
E
V
G
F
F
L
A
E
D
F
Y
W
F
N
P
S
-------
K
L
P
S
P
I
E
W
V
--------
N
K
R
K
I
R
---
V
K
D
A
V
N
T
V
W
W
F
-------
S
K
T
E
----
W
P
K
S
D
ITKVL
A
---------------------------------------
S
I
P
P
N
-----
L
L
Q
-
I
S
-----
N
S
E
SNG
Q
Y
L
A
N
C
K
L
M
--
G
I
K
A
------
H
P
A
R
F
P
A
K
L
P
E
F
F
I
R
M
L
T
-
E
P
D
D
L
V
V
D
I
---
F
G
G
S
N
T
T
G
L
V
A
E
R
E
S
----------------------------------------
R
K
W
---
I
S
F
E
M
K
------------
P
E
Y
V
A
A
S
A
F
R
F
L
D
N
N
I
S
E
------------------------------------------------------------------------------------------------
50
Fugue
84.26
22%
-69
- C5 -
1BOO
1
MTP2_PROHU
A:
[3-322]
NFG
K
K
P
A
Y
T
T
S
N
G
S
M
Y
I
G
D
S
L
E
L
L
E
S
F
P
E
E
S
I
S
L
V
M
T
S
P
P
F
A
L
Q
--
R
K
K
E
Y
G
-------
N
-----
L
E
Q
H
E
Y
V
D
W
--
F
L
S
F
A
K
V
V
N
K
-
K
L
K
P
D
G
S
F
V
V
D
F
G
G
A
-
Y
M
K
G
--
V
--
P
---
A
---
R
SI
Y
N
-
F
R
V
L
I
R
M
I
D
E
V
G
F
F
L
A
E
D
F
Y
W
F
N
P
S
-------
K
L
P
S
P
-
I
--
E
----
W
V
-
N
K
R
K
I
R
---
V
K
D
A
V
N
T
V
W
W
F
-------
S
K
T
E
----
W
P
K
S
D
-----
I
--------
T
--
K
V
-----------------
L
A
S
--
I
P
P
N
L
L
Q
I
S
-----
N
S
E
-
S
N
-----
G
Q
Y
-----------
L
--
A
N
C
K
L
M
GIKA
H
P
A
R
F
P
A
K
L
P
E
F
F
I
R
M
L
T
-
E
P
D
D
L
V
V
D
I
---
F
G
G
S
N
T
T
G
L
V
A
E
R
E
S
----------------------------------------
R
K
W
---
I
S
F
E
M
K
------------
P
E
Y
V
A
A
S
A
F
R
F
L
D
N
N
I
S
E
E
K
I
T
D
I
Y
N
R
I
L
N
GESLDLNSI---------------------------------------------------------------------------
7
PsiBlast_PDB
80.94
24%
-67
- C5 -
1NW6
3
MTR1_RHOSH
A:
[61-284]
---------------------------------
L
I
I
C
D
P
P
Y
N
I
M
--
L
A
------------
D
---
W
D
D
H
M
D
Y
I
G
W
--
A
K
R
W
L
A
E
A
E
R
-
V
L
S
P
T
G
S
I
A
I
F
G
G
L
Q
Y
Q
G
E
A
--
G
--
S
---
G
---
D
---
L
-
I
S
I
I
S
H
M
R
Q
N
S
K
M
L
L
A
N
L
I
I
W
N
Y
P
N
G
M
S
A
QRF
F
A
N
R
H
-
E
E
I
A
----
W
F
-
A
K
T
K
K
Y
---
F
F
-
D
L
D
A
V
R
E
P
-------
Y
D
E
E
T
K
A
A
Y
M
K
D
K
-----
R
--------
L
--
N
P
-----------------
E
S
V
--
E
K
G
R
N
P
T
N
------
V
W
R
-
M
S
RLN--
G
N
S
-----------
L
--
E
R
V
G
------
H
P
T
Q
K
P
A
A
V
I
E
R
L
V
R
A
L
S
-
H
P
G
S
T
V
L
D
F
---
F
A
G
S
G
V
T
A
R
V
A
I
Q
E
G
----------------------------------------
R
N
S
---
I
C
T
D
A
A
------------
P
V
F
K
E
Y
Y
Q
K
Q
L
T
F
L
Q
R
S
Y
------------------------------------------------------------------------------------------------
26
HHSearch
80.90
25%
-77
* C5 *
1G60
3
MTM2_MORBO
A:
[3-256]
----------
E
I
N
K
I
H
Q
M
N
C
F
D
F
L
D
Q
V
E
N
K
S
V
Q
L
A
V
I
D
P
P
Y
N
L
S
--
K
A
D
W
D
---------
S
---
F
D
S
H
N
E
F
L
A
F
--
T
Y
R
W
I
D
K
V
L
D
-
K
L
D
K
D
G
S
L
Y
I
F
N
T
P
F
-
N
C
----------------------
A
F
I
C
Q
Y
L
V
S
K
G
M
I
F
Q
N
W
I
T
W
D
K
R
D
-------
G
M
G
S
A
---------------
K
R
R
---
F
S
T
G
Q
E
T
I
L
F
F
-------
S
K
S
K
----
N
H
T
F
N
-----
Y
DE
V
R
V
---
P
Y
E
S
T
D
R
I
K
H
A
S
E
K
GILKNG
K
R
W
F
P
--
N
P
N
G
R
L
C
G
E
-----
V
W
H
-
F
S
----------------------------------
T
P
K
P
R
D
L
I
E
R
I
I
R
A
S
S
-
N
P
N
D
L
V
L
D
C
---
F
M
G
S
G
T
T
A
I
V
A
K
K
L
G
----------------------------------------
R
N
F
---
I
G
C
D
M
N
------------
A
E
Y
V
N
Q
A
N
F
V
L
N
Q
-----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.57
24%
-70
- C5 -
1EG2
1
MTR1_RHOSH
A:
[61-284]
---------------------------------
L
I
I
C
D
P
P
Y
N
I
M
--
L
A
------------
D
---
W
D
D
H
M
D
Y
I
G
W
--
A
K
R
W
L
A
E
A
E
R
-
V
L
S
P
T
G
S
I
A
I
F
G
G
L
Q
Y
Q
G
E
A
--
G
--
S
---
G
---
D
---
L
-
I
S
I
I
S
H
M
R
Q
N
S
K
M
L
L
A
N
L
I
I
W
N
Y
P
N
G
M
S
A
QRF
F
A
N
R
H
-
E
E
I
A
----
W
F
-
A
K
T
K
K
Y
---
F
F
-
D
L
D
A
V
R
E
P
-------
Y
D
E
E
T
K
A
A
Y
M
K
D
K
-----
R
--------
L
--
N
P
-----------------
E
S
V
--
E
K
G
R
N
P
T
N
------
V
W
R
-
M
S
RLN--
G
N
S
-----------
L
--
E
R
V
G
------
H
P
T
Q
K
P
A
A
V
I
E
R
L
V
R
A
L
S
-
H
P
G
S
T
V
L
D
F
---
F
A
G
S
G
V
T
A
R
V
A
I
Q
E
G
----------------------------------------
R
N
S
---
I
C
T
D
A
A
------------
P
V
F
K
E
Y
Y
Q
K
Q
L
T
F
L
R
S
Y
E
------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.33
24%
-67
- C5 -
1NW5
2
MTR1_RHOSH
A:
[61-284]
---------------------------------
L
I
I
C
D
P
P
Y
N
I
M
--
L
A
------------
D
---
W
D
D
H
M
D
Y
I
G
W
--
A
K
R
W
L
A
E
A
E
R
-
V
L
S
P
T
G
S
I
A
I
F
G
G
L
Q
Y
Q
G
E
A
--
G
--
S
---
G
---
D
---
L
-
I
S
I
I
S
H
M
R
Q
N
S
K
M
L
L
A
N
L
I
I
W
N
Y
P
N
G
M
S
A
QRF
F
A
N
R
H
-
E
E
I
A
----
W
F
-
A
K
T
K
K
Y
---
F
F
-
D
L
D
A
V
R
E
P
-------
Y
D
E
E
T
K
A
A
Y
M
K
D
K
-----
R
--------
L
--
N
P
-----------------
E
S
V
--
E
K
G
R
N
P
T
N
------
V
W
R
-
M
S
RLN--
G
N
S
-----------
L
--
E
R
V
G
------
H
P
T
Q
K
P
A
A
V
I
E
R
L
V
R
A
L
S
-
H
P
G
S
T
V
L
D
F
---
F
A
G
S
G
V
T
A
R
V
A
I
Q
E
G
----------------------------------------
R
N
S
---
I
C
T
D
A
A
------------
P
V
F
K
E
Y
Y
Q
K
Q
L
T
F
L
R
S
Y
E
------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.65
24%
-67
- C5 -
1NW8
2
MTR1_RHOSH
A:
[61-284]
---------------------------------
L
I
I
C
D
P
P
Y
N
I
M
-------
P
-------
A
D
---
W
D
D
H
M
D
Y
I
G
W
--
A
K
R
W
L
A
E
A
E
R
-
V
L
S
P
T
G
S
I
A
I
F
G
G
L
Q
Y
Q
G
E
A
--
G
--
S
---
G
---
D
---
L
-
I
S
I
I
S
H
M
R
Q
N
S
K
M
L
L
A
N
L
I
I
W
N
Y
P
N
G
M
S
A
QRF
F
A
N
R
H
-
E
E
I
A
----
W
F
-
A
K
T
K
K
Y
---
F
F
-
D
L
D
A
V
R
E
P
-------
Y
D
E
E
T
K
A
A
Y
M
K
D
K
-----
R
--------
L
--
N
P
-----------------
E
S
V
--
E
K
G
R
N
P
T
N
------
V
W
R
-
M
S
RLN--
G
N
S
-----------
L
--
E
R
V
G
------
H
P
T
Q
K
P
A
A
V
I
E
R
L
V
R
A
L
S
-
H
P
G
S
T
V
L
D
F
---
F
A
G
S
G
V
T
A
R
V
A
I
Q
E
G
----------------------------------------
R
N
S
---
I
C
T
D
A
A
------------
P
V
F
K
E
Y
Y
Q
K
Q
L
T
F
L
Q
R
S
Y
------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.54
29%
-47
- C5 -
2ZIE
-
?
A:
[24-276]
--------------
L
H
V
G
D
A
R
E
V
L
A
S
F
P
E
A
S
V
H
L
V
V
T
S
P
P
Y
W
T
L
--------QL
G
H
I
--
E
D
---
Y
E
A
F
L
D
E
L
D
R
--
V
W
R
E
V
F
R
L
L
V
-
P
G
G
R
L
V
I
V
V
G
D
V
A
V
A
-
R
--------
R
---
H
L
V
F
P
---
L
-
H
A
D
I
Q
V
R
C
R
K
L
G
F
D
N
L
N
P
I
I
W
H
K
H
-----------------------------
P
Y
EPG
A
I
I
K
T
E
I
E
Y
I
L
M
Q
R
K
P
G
G
Y
R
K
P
----
T
Q
E
Q
R
-----
E
--------
K
--
S
R
-----------------
L
P
K
--
E
D
F
H
R
F
F
R
Q
-----
I
W
D
D
I
P
-----------------------------------
P
F
P
L
E
L
A
E
R
L
V
R
M
F
S
-
F
V
G
D
V
V
L
D
P
---
F
A
G
T
G
T
T
L
I
A
A
A
R
W
G
----------------------------------------
R
R
A
---
L
G
V
E
L
V
------------
P
R
Y
A
Q
L
A
K
E
R
F
A
R
E
V
P
G
F
------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.39
24%
-69
- C5 -
1NW7
3
MTR1_RHOSH
A:
[61-284]
---------------------------------
L
I
I
C
D
P
P
Y
N
I
M
--
L
A
------------
D
---
W
D
D
H
M
D
Y
I
G
W
--
A
K
R
W
L
A
E
A
E
R
-
V
L
S
P
T
G
S
I
A
I
F
G
G
L
Q
Y
Q
G
E
A
--
G
--
S
---
G
---
D
---
L
-
I
S
I
I
S
H
M
R
Q
N
S
K
M
L
L
A
N
L
I
I
W
N
Y
P
N
G
M
S
A
QRF
F
A
N
R
H
-
E
E
I
A
----
W
F
-
A
K
T
K
K
Y
---
F
F
-
D
L
D
A
V
R
E
P
-------
Y
D
E
E
T
K
A
A
Y
M
K
D
K
-----
R
--------
L
--
N
P
-----------------
E
S
V
--
E
K
G
R
N
P
T
N
------
V
W
R
-
M
S
RLN--
G
N
S
-----------
L
--
E
R
V
G
------
H
P
T
Q
K
P
A
A
V
I
E
R
L
V
R
A
L
S
-
H
P
G
S
T
V
L
D
F
---
F
A
G
S
G
V
T
A
R
V
A
I
Q
E
G
----------------------------------------
R
N
S
---
I
C
T
D
A
A
------------
P
V
F
K
E
Y
Y
Q
K
Q
L
T
F
L
Q
R
S
Y
------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.10
24%
-87
- C5 -
1G60
3
MTM2_MORBO
A:
[16-246]
-----------------------
L
D
Q
V
E
N
K
S
V
Q
L
A
V
I
D
P
P
Y
N
L
S
--
K
A
D
W
D
S
------------
F
D
S
H
N
E
F
L
A
F
--
T
Y
R
W
I
D
K
V
L
D
K
L
D
K
D
G
S
L
Y
I
F
N
T
P
F
N
-
C
-----------------------
A
F
I
C
Q
Y
L
V
S
K
G
M
I
F
Q
N
W
I
T
W
D
K
R
D
GMGS---
A
K
R
R
F
-
S
T
G
Q
E
T
I
L
F
F
-
S
K
S
K
N
H
---
T
F
N
Y
D
E
V
R
V
P
Y
-------
E
S
T
D
----
R
I
K
H
A
-----
S
--------
E
--
K
G
-----------------
I
L
K
NG
K
R
W
F
P
N
P
N
G
RLCGE
V
W
H
-
F
S
----------------------------------
T
P
K
P
R
D
L
I
E
R
I
I
R
A
S
S
-
N
P
N
D
L
V
L
D
C
---
F
M
G
S
G
T
T
A
I
V
A
K
K
L
G
----------------------------------------
R
N
F
---
I
G
C
D
M
N
------------
A
E
Y
V
N
Q
A
N
F
V
L
N
Q
-----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.84
36%
-1
- C5 -
1BOO
1
MTP2_PROHU
A:
[233-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
A
R
F
P
A
K
L
P
E
F
F
I
R
M
L
T
-
E
P
D
D
L
V
V
D
I
---
F
G
G
S
N
T
T
G
L
V
A
E
R
E
S
----------------------------------------
R
K
W
---
I
S
F
E
M
K
------------
P
E
Y
V
A
A
S
A
F
R
F
L
D
N
N
I
S
E
------------------------------------------------------------------------------------------------
57
Fugue
46.30
14%
-27
- C3 -
4WD8
4
?
A:
[25-292]
---
S
K
I
I
F
R
L
L
L
N
V
L
M
S
I
I
A
-
I
I
S
Y
Q
W
Y
E
Q
L
G
I
H
L
T
V
A
P
F
S
L
L
G
--
I
A
I
A
I
F
-------
L
G
---
F
R
N
S
A
S
Y
S
R
F
V
E
A
R
N
L
W
G
T
V
L
I
-
A
E
R
T
L
V
R
Q
L
R
N
I
L
------
P
--
A
--
E
---
H
---
D
---
A
-
H
R
R
I
V
S
Y
L
V
A
F
S
W
S
L
K
H
Q
L
R
K
T
D
P
T
-------
A
D
L
R
R
-
L
L
P
E
----
E
R
-
V
T
E
I
L
A
---
S
S
M
P
T
N
R
I
L
L
L
-------
A
G
N
E
----
I
G
Q
L
R
-----
E
--------
A
--
G
K
-----------------
L
S
D
--
I
T
Y
G
L
M
D
N
K
-----
L
D
E
-
L
A
H
V
L
G
G
C
E
R
-----------
L
--
A
T
T
P
------
V
P
F
A
Y
T
L
I
L
Q
R
T
V
Y
L
F
C
T
-
L
L
P
F
A
L
V
G
D
LHY
M
T
P
F
V
S
V
F
I
S
Y
T
F
L
S
----------------------------------------
W
D
S
---
L
A
E
E
L
E
D
PFGTAANDLP
L
N
A
M
C
N
T
I
E
R
N
L
L
D
M
T
G
Q
-------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.13
34%
-65
- C5 -
3TM5
1
?
A:
[198-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
V
L
D
P
---
M
C
G
S
G
T
I
L
I
E
L
-
A
L
R
----------------------------------------
R
Y
S
G
E
I
I
G
I
E
K
Y
------------
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
------------------------------------------------------------------------------------------------
32
HHSearch
44.48
27%
-4
- C5 -
3K0B
-
?
A:
[180-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
F
Y
D
P
---
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
NIAPGFNREFVSETWDWMP
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
ANYDQP
L
N
I
---
I
G
G
D
I
D
------------
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
------------------------------------------------------------------------------------------------
52
Fugue
43.92
13%
-18
* C4 *
3TM4
1
?
A:
[1-370]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
-
E
V
S
L
L
L
K
K
L
G
I
S
F
Q
I
E
E
K
P
L
G
I
E
G
R
L
L
L
E
A
E
-------
K
A
---
Y
Y
V
D
E
K
G
R
K
R
--
E
L
S
I
S
T
Y
L
N
E
-
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
-
K
F
N
G
IE
K
--
D
---
E
---
S
---
E
-
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
-------
A
V
R
S
F
-
R
K
G
D
----
H
N
-
I
T
S
I
D
I
---
A
R
T
V
G
E
A
I
F
E
R
-------
L
S
R
F
----
G
T
P
L
V
-----
N
LDHPA
V
I
F
R
--
A
E
-----------------
L
I
K
--
D
V
F
F
L
G
I
D
T
-----
T
G
D
-
S
S
-----
L
H
K
-----------
R
PW
R
V
Y
D
------
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
V
L
D
P
---
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
----------------------------------------
Y
S
G
E
I
-
I
G
I
E
K
Y
------------
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
QGDATQLSQYVDSVD
F
A
I
S
NLPYGSM
I
P
D
L
Y
M
K
F
F
N
E
L
A
K
VLE
K
R
G
V
F
I
T
TE
K
K
A
I
E
E
A
I
A
E
N
GFEII
H
H
R
V
I
G
H
GGLM
V
H
L
Y
V
V
K
LEHHH
22
PsiBlast_CBE
43.73
34%
-62
- C5 -
3TM4
1
?
B:
[198-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
V
L
D
P
---
M
C
G
S
G
T
I
L
I
E
L
-
A
L
R
----------------------------------------
R
Y
S
GEI
I
G
I
E
K
Y
------------
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.73
34%
-59
- C5 -
3TLJ
2
?
A:
[198-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
V
L
D
P
---
M
C
G
S
G
T
I
L
I
E
L
-
A
L
R
----------------------------------------
R
Y
S
G
E
I
I
G
I
E
K
Y
------------
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
------------------------------------------------------------------------------------------------