@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0337: (2015-12-14 )
MQLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALVYSLLHLWGFDLSLDDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQTLLDKEAISHKVYCLCGDGDLQEGISYESTSLAGHLRLDNLIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHDYQAIHNALEEAKKSHKPTLLIAHTIIGKGAIGLEGSEKTHGSPLSKEVLKQSKENAQINPNESFIISPKNKMHFEEVKVRGISLEALWEKSLSPKTKEKIHALKNFDFNAINYPAFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTHLKHSGDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPHFYAFRPSDAFENKACMQVALSLNAPSALILSRQNLSVLDEVSKEQVLKGAYVKHHSKDPIITLVASGSEVSLALESAKILERENIPTQVVSAPCFDLLVEQDESYFKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
Atome Classification :
(21 SA)
......-...10....-....20........30........40......-..-50...-..-....60........70........80......-..90........100.......110.......120.......130.......140...------.---.---..---150.......160.......170.......180.......190.......200.......210..-..--.-.-.220.--.......230..-.-..-.-.240.......250.......260.......270.......280.......290......-.300-.......310...------..-..-320..-.-------------.-----.---------.----------.330.---------.---------...--..340.----......350.......360.......370.......-------------380---.------.-....---------.----.390.......400.......410-.-.-......420.......430.......440.......450.......460.......470.......480.......490-.-.---.-....500......--.510---..---....---.-520--.....---...------.530.--.-.....540.......550.......560.......570.......580.--.---.--..---..590.......600---.---.---.....610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQL
S
N
A
-
D
L
E
R
L
K
S
M
A
-
N
T
L
R
F
L
C
A
D
M
I
DKANSGHP
G
V
C
L
G
L
A
D
V
M
V
V
L
-
S
L
-
H
-
L
NL-NP-TNPKWLNRD
R
L
V
FSGG
H
A
S
A
L
V
Y
S
L
L
H
LWGFD-L
S
L
D
D
L
K
R
F
R
Q
L
HSKTPGHPELHHTE
G
I
E
I
TTGPLG
Q
G
F
A
N
A
V
G
F
S
M
A
S
Q
Y
A
Q
T
L
L
D
K
------
E
---A---IS---
H
K
V
Y
C
L
CGD
G
D
L
Q
EGISYESTSLAG
H
L
R
L
D
N
L
I
V
I
Y
DS
N
Q
I
S
I
E
G
A
I
N
I
S
F
S
E
Q
V
K
T
R
F
L
AQN
W
E
-
V
L
--
E
-C-DGH-
D
--
Y
Q
A
I
H
N
A
L
E
E
A
K
-
K
-SH-K-
P
T
L
L
I
A
H
T
I
IGKGAIGLEGSEKTHGSP
L
S
K
E
V
L
K
QSKENAQINPNE
S
F
I
ISPKNKM
H
F
E
E
-
V
K
V
R-GI
S
L
E
A
L
W
E
KSLS------P
K
-
T
K
-
E
K
I
H
A
-
L
-------------K-----N---------F----------DFNAI---------N---------YPA--FKK
G
E
S
----
L
A
T
R
VSN
G
M
I
L
N
A
I
A
K
E
C
E
G
FLGGSADLAPSNNT
H
L
-------------KH----S------G-DFPL---------G----QNL
H
F
G
I
R
E
H
A
M
G
A
I
T
N
A
L
A
A
Y
-
G
-
L
-
F
-
V
P
F
C
A
T
F
F
V
F
S
D
Y
LM
P
S
I
R
L
S
A
L
M
K
L
K
A
L
F
I
F
THDSIGVGEDGATH
Q
P
I
E
Q
L
S
H
L
R
ALPH
F
Y
AFRPSDAFE
N
K
A
C
M
Q
V
A
-
L
-S---L-NAP
S
A
L
I
L
SRQ
N
L
--
S
V
L
D
---
E
V
---
S
K
E
Q
---
V
-
L
----
K
G
A
Y
V
---KHH------SKD
P
I
--
I
-
T
L
V
ASG
S
E
V
S
L
A
L
E
S
A
K
I
L
E
RENI
P
T
Q
V
VSA
P
C
F
D
L
L
V
EQ
D
E
S
Y
F
K
E
L
F--K---G--
K
V
---
L
V
I
EASRA
I
E
W
Y
R
F
A
---
D
---
K
---IIGMDSFGSSAK
G
D
K
L
F
E
K
FGF
S
V
E
N
I
T
A
Q
A
K
R
L
LNA
1
PsiBlast_PDB
95.77
59%
-88
- C1 -
3M7I
4
?
A:
[4-629]
------M
N
I
Q
I
L
Q
E
Q
A
-
N
T
L
R
F
L
S
A
D
M
V
Q
K
A
N
S
G
H
P
G
A
P
L
G
L
A
D
I
L
S
V
L
-
S
Y
-
H
-
L
K
H
-
N
P
-
K
N
P
T
W
L
N
R
D
R
L
V
F
S
G
G
H
A
S
A
L
L
Y
S
F
L
H
L
S
G
Y
D
-
L
S
L
E
D
L
K
N
F
R
Q
L
H
S
K
T
P
G
H
P
E
I
S
-
T
L
G
V
E
I
A
T
G
P
L
G
Q
G
V
A
N
A
V
G
F
A
M
A
A
K
K
A
Q
N
L
L
G
S
------
D
---
L
---
I
D
---
H
K
I
Y
C
L
C
G
D
G
D
L
Q
E
G
I
S
Y
E
A
C
S
L
A
G
L
H
K
L
D
N
F
I
L
I
Y
D
S
N
N
I
S
I
E
G
D
V
G
L
A
F
N
E
N
V
K
M
R
F
E
A
Q
G
F
E
-
V
L
--
S
-
I
-
N
G
H
-
D
--
Y
E
E
I
N
K
A
L
E
Q
A
K
-
K
-
S
T
-
K
-
P
C
L
I
I
A
K
T
T
I
A
K
G
A
G
E
L
E
G
S
H
K
S
H
G
A
P
L
G
E
E
V
I
K
K
A
K
E
Q
A
G
F
D
P
N
I
S
F
H
I
P
Q
A
S
K
I
R
F
E
S
-
A
V
E
L
-
G
D
L
E
E
A
K
W
K
D
K
L
E
------
K
S
-
A
K
K
E
L
L
E
R
-
L
-------------
L
-----
N
---------
P
----------
D
F
N
K
I
---------
A
---------
Y
P
D
--
F
K
-
G
K
D
----
L
A
T
R
D
S
N
G
E
I
L
N
V
L
A
K
N
L
E
G
F
L
G
G
S
A
D
L
G
P
S
N
K
T
E
L
-------------
H
S
----
M
------
G
-
D
F
V
E
---------
G
----
K
N
I
H
F
G
I
R
E
H
A
M
A
A
I
N
N
A
F
A
R
Y
-
G
-
I
-
F
-
L
P
F
S
A
T
F
F
I
F
S
E
Y
L
K
P
A
A
R
I
A
A
L
M
K
I
K
H
F
F
I
F
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
Q
L
S
T
F
R
A
M
P
N
F
L
T
F
R
P
A
D
G
V
E
N
V
K
A
W
Q
I
A
-
L
-
N
---
A
-
D
I
P
S
A
F
V
L
S
R
Q
K
L
--
K
A
L
N
---
E
P
---
V
F
G
D
---
V
-
K
----
N
G
A
Y
L
---
L
K
E
------
S
K
E
A
K
--
F
-
T
L
L
A
S
G
S
E
V
W
L
C
L
E
S
A
N
E
L
E
K
Q
G
F
A
C
N
V
V
S
M
P
C
F
E
L
F
E
K
Q
D
K
A
Y
Q
E
R
L
L
--
K
---
G
--
E
V
---
I
G
V
E
A
A
H
S
N
E
L
Y
K
F
C
---
H
---
K
---
V
Y
G
I
E
S
F
G
E
S
G
K
D
K
D
V
F
E
R
F
G
F
S
V
S
K
L
V
N
F
I
L
S
K
---
2
PsiBlast_PDB
95.65
59%
-89
- C1 -
3M34
5
?
A:
[4-629]
------M
N
I
Q
I
L
Q
E
Q
A
-
N
T
L
R
F
L
S
A
D
M
V
Q
K
A
N
S
G
H
P
G
A
P
L
G
L
A
D
I
L
S
V
L
-
S
Y
-
H
-
L
K
H
-
N
P
-
K
N
P
T
W
L
N
R
D
R
L
V
F
S
G
G
H
A
S
A
L
L
Y
S
F
L
H
L
S
G
Y
D
-
L
S
L
E
D
L
K
N
F
R
Q
L
H
S
K
T
P
G
H
P
E
I
S
-
T
L
G
V
E
I
A
T
G
P
L
G
Q
G
V
A
N
A
V
G
F
A
M
A
A
K
K
A
Q
N
L
L
G
S
------
D
---
L
---
I
D
---
H
K
I
Y
C
L
C
G
D
G
D
L
Q
E
G
I
S
Y
E
A
C
S
L
A
G
L
H
K
L
D
N
F
I
L
I
Y
D
S
N
N
I
S
I
E
G
D
V
G
L
A
F
N
E
N
V
K
M
R
F
E
A
Q
G
F
E
-
V
L
--
S
-
I
-
N
G
H
-
D
--
Y
E
E
I
N
K
A
L
E
Q
A
K
-
K
-
S
T
-
K
-
P
C
L
I
I
A
K
T
T
I
A
K
G
A
G
E
L
E
G
S
H
K
S
H
G
A
P
L
G
E
E
V
I
K
K
A
K
E
Q
A
G
F
D
P
N
I
S
F
H
I
P
Q
A
S
K
I
R
F
E
S
-
A
V
E
L
-
G
D
L
E
E
A
K
W
K
D
K
L
E
------
K
S
-
A
K
K
E
L
L
E
R
-
L
-------------
L
-----
N
---------
P
----------
D
F
N
K
I
---------
A
---------
Y
P
D
--
F
K
-
G
K
D
----
L
A
T
R
D
S
N
G
E
I
L
N
V
L
A
K
N
L
E
G
F
L
G
G
S
A
D
L
G
P
S
N
K
T
E
L
-------------
H
S
----
M
------
G
-
D
F
V
E
---------
G
----
K
N
I
H
F
G
I
R
E
H
A
M
A
A
I
N
N
A
F
A
R
Y
-
G
-
I
-
F
-
L
P
F
S
A
T
F
F
I
F
S
E
Y
L
K
P
A
A
R
I
A
A
L
M
K
I
K
H
F
F
I
F
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
Q
L
S
T
F
R
A
M
P
N
F
L
T
F
R
P
A
D
G
V
E
N
V
K
A
W
Q
I
A
-
L
-
N
---
A
-
D
I
P
S
A
F
V
L
S
R
Q
K
L
--
K
A
L
N
---
E
P
---
V
F
G
D
---
V
-
K
----
N
G
A
Y
L
---
L
K
E
------
S
K
E
A
K
--
F
-
T
L
L
A
S
G
S
E
V
W
L
C
L
E
S
A
N
E
L
E
K
Q
G
F
A
C
N
V
V
S
M
P
C
F
E
L
F
E
K
Q
D
K
A
Y
Q
E
R
L
L
--
K
---
G
--
E
V
---
I
G
V
E
A
A
H
S
N
E
L
Y
K
F
C
---
H
---
K
---
V
Y
G
I
E
S
F
G
E
S
G
K
D
K
D
V
F
E
R
F
G
F
S
V
S
K
L
V
N
F
I
L
S
K
---
3
PsiBlast_PDB
95.33
59%
-89
- C1 -
3M6L
6
?
A:
[4-629]
------M
N
I
Q
I
L
Q
E
Q
A
-
N
T
L
R
F
L
S
A
D
M
V
Q
K
A
N
S
G
H
P
G
A
P
L
G
L
A
D
I
L
S
V
L
-
S
Y
-
H
-
L
K
H
-
N
P
-
K
N
P
T
W
L
N
R
D
R
L
V
F
S
G
G
H
A
S
A
L
L
Y
S
F
L
H
L
S
G
Y
D
-
L
S
L
E
D
L
K
N
F
R
Q
L
H
S
K
T
P
G
H
P
E
I
S
-
T
L
G
V
E
I
A
T
G
P
L
G
Q
G
V
A
N
A
V
G
F
A
M
A
A
K
K
A
Q
N
L
L
G
S
------
D
---
L
---
I
D
---
H
K
I
Y
C
L
C
G
D
G
D
L
Q
E
G
I
S
Y
E
A
C
S
L
A
G
L
H
K
L
D
N
F
I
L
I
Y
D
S
N
N
I
S
I
E
G
D
V
G
L
A
F
N
E
N
V
K
M
R
F
E
A
Q
G
F
E
-
V
L
--
S
-
I
-
N
G
H
-
D
--
Y
E
E
I
N
K
A
L
E
Q
A
K
-
K
-
S
T
-
K
-
P
C
L
I
I
A
K
T
T
I
A
K
G
A
G
E
L
E
G
S
H
K
S
H
G
A
P
L
G
E
E
V
I
K
K
A
K
E
Q
A
G
F
D
P
N
I
S
F
H
I
P
Q
A
S
K
I
R
F
E
S
-
A
V
E
L
-
G
D
L
E
E
A
K
W
K
D
K
L
E
------
K
S
-
A
K
K
E
L
L
E
R
-
L
-------------
L
-----
N
---------
P
----------
D
F
N
K
I
---------
A
---------
Y
P
D
--
F
K
-
G
K
D
----
L
A
T
R
D
S
N
G
E
I
L
N
V
L
A
K
N
L
E
G
F
L
G
G
S
A
D
L
G
P
S
N
K
T
E
L
-------------
H
S
----
M
------
G
-
D
F
V
E
---------
G
----
K
N
I
H
F
G
I
R
E
H
A
M
A
A
I
N
N
A
F
A
R
Y
-
G
-
I
-
F
-
L
P
F
S
A
T
F
F
I
F
S
E
Y
L
K
P
A
A
R
I
A
A
L
M
K
I
K
H
F
F
I
F
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
Q
L
S
T
F
R
A
M
P
N
F
L
T
F
R
P
A
D
G
V
E
N
V
K
A
W
Q
I
A
-
L
-
N
---
A
-
D
I
P
S
A
F
V
L
S
R
Q
K
L
--
K
A
L
N
---
E
P
---
V
F
G
D
---
V
-
K
----
N
G
A
Y
L
---
L
K
E
------
S
K
E
A
K
--
F
-
T
L
L
A
S
G
S
E
V
W
L
C
L
E
S
A
N
E
L
E
K
Q
G
F
A
C
N
V
V
S
M
P
C
F
E
L
F
E
K
Q
D
K
A
Y
Q
E
R
L
L
--
K
---
G
--
E
V
---
I
G
V
E
A
A
H
S
N
E
L
Y
K
F
C
---
H
---
K
---
V
Y
G
I
E
S
F
G
E
S
G
K
D
K
D
V
F
E
R
F
G
F
S
V
S
K
L
V
N
F
I
L
S
K
---
4
PsiBlast_PDB
94.38
59%
-89
- C1 -
3L84
3
?
A:
[2-626]
-------
N
I
Q
I
L
Q
E
Q
A
-
N
T
L
R
F
L
S
A
D
M
V
Q
K
A
N
S
G
H
P
G
A
P
L
G
L
A
D
I
L
S
V
L
-
S
Y
-
H
-
L
K
H
-
N
P
-
K
N
P
T
W
L
N
R
D
R
L
V
F
S
G
G
H
A
S
A
L
L
Y
S
F
L
H
L
S
G
Y
D
-
L
S
L
E
D
L
K
N
F
R
Q
L
H
S
K
T
P
G
H
P
E
I
S
-
T
L
G
V
E
I
A
T
G
P
L
G
Q
G
V
A
N
A
V
G
F
A
M
A
A
K
K
A
Q
N
L
L
G
S
------
D
---
L
---
I
D
---
H
K
I
Y
C
L
C
G
D
G
D
L
Q
E
G
I
S
Y
E
A
C
S
L
A
G
L
H
K
L
D
N
F
I
L
I
Y
D
S
N
N
I
S
I
E
G
D
V
G
L
A
F
N
E
N
V
K
M
R
F
E
A
Q
G
F
E
-
V
L
--
S
-
I
-
N
G
H
-
D
--
Y
E
E
I
N
K
A
L
E
Q
A
K
-
K
-
S
T
-
K
-
P
C
L
I
I
A
K
T
T
I
A
K
G
A
G
E
L
E
G
S
H
K
S
H
G
A
P
L
G
E
E
V
I
K
K
A
K
E
Q
A
G
F
D
P
N
I
S
F
H
I
P
Q
A
S
K
I
R
F
E
S
-
A
V
E
L
-
G
D
L
E
E
A
K
W
K
D
K
L
E
------
K
S
-
A
K
K
E
L
L
E
R
-
L
-------------
L
-----
N
---------
P
----------
D
F
N
K
I
---------
A
---------
Y
P
D
--
F
K
-
G
K
D
----
L
A
T
R
D
S
N
G
E
I
L
N
V
L
A
K
N
L
E
G
F
L
G
G
S
A
D
L
G
P
S
N
K
T
E
L
-------------
H
S
----
M
------
G
-
D
F
V
E
---------
G
----
K
N
I
H
F
G
I
R
E
H
A
M
A
A
I
N
N
A
F
A
R
Y
-
G
-
I
-
F
-
L
P
F
S
A
T
F
F
I
F
S
E
Y
L
K
P
A
A
R
I
A
A
L
M
K
I
K
H
F
F
I
F
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
Q
L
S
T
F
R
A
M
P
N
F
L
T
F
R
P
A
D
G
V
E
N
V
K
A
W
Q
I
A
-
L
-
N
---
A
-
D
I
P
S
A
F
V
L
S
R
Q
K
L
--
K
A
L
N
---
E
P
---
V
F
G
D
---
V
-
K
----
N
G
A
Y
L
---
L
K
E
------
S
K
E
A
K
--
F
-
T
L
L
A
S
G
S
E
V
W
L
C
L
E
S
A
N
E
L
E
K
Q
G
F
A
C
N
V
V
S
M
P
C
F
E
L
F
E
K
Q
D
K
A
Y
Q
E
R
L
L
--
K
---
G
--
E
V
---
I
G
V
E
A
A
H
S
N
E
L
Y
K
F
C
---
H
---
K
---
V
Y
G
I
E
S
F
G
E
S
G
K
D
K
D
V
F
E
R
F
G
F
S
V
S
K
L
V
N
F
I
L
S
K
---
54
HHSearch
94.22
59%
-88
- C1 -
3L84
3
?
A:
[2-631]
-------
N
I
Q
I
L
Q
E
Q
A
-
N
T
L
R
F
L
S
A
D
M
V
Q
K
A
N
S
G
H
P
G
A
P
L
G
L
A
D
I
L
S
V
L
-
S
Y
-
H
-
L
K
H
-
N
P
-
K
N
P
T
W
L
N
R
D
R
L
V
F
S
G
G
H
A
S
A
L
L
Y
S
F
L
H
L
S
G
Y
D
-
L
S
L
E
D
L
K
N
F
R
Q
L
H
S
K
T
P
G
H
P
E
I
-
S
T
L
G
V
E
I
A
T
G
P
L
G
Q
G
V
A
N
A
V
G
F
A
M
A
A
K
K
A
Q
N
L
L
G
S
------
D
---
L
---
I
D
---
H
K
I
Y
C
L
C
G
D
G
D
L
Q
E
G
I
S
Y
E
A
C
S
L
A
G
L
H
K
L
D
N
F
I
L
I
Y
D
S
N
N
I
S
I
E
G
D
V
G
L
A
F
N
E
N
V
K
M
R
F
E
A
Q
G
F
E
-
V
L
--
S
-
I
-
N
G
H
-
D
--
Y
E
E
I
N
K
A
L
E
Q
A
K
-
K
-
S
T
-
K
-
P
C
L
I
I
A
K
T
T
I
A
K
G
A
G
E
L
E
G
S
H
K
S
H
G
A
P
L
G
E
E
V
I
K
K
A
K
E
Q
A
G
F
D
P
N
I
S
F
H
I
P
Q
A
S
K
I
R
F
E
S
-
A
V
E
L
-
G
D
L
E
E
A
K
W
K
D
K
L
E
------
K
S
-
A
K
-
K
E
L
L
E
R
L
-------------
L
-----
N
---------
P
----------
D
F
N
K
I
---------
A
---------
Y
P
D
--
F
--
K
G
K
D
---
L
A
T
R
D
S
N
G
E
I
L
N
V
L
A
K
N
L
E
G
F
L
G
G
S
A
D
L
G
P
S
N
K
T
E
L
-------------
H
S
----
M
------
G
-
D
F
V
E
---------
G
----
K
N
I
H
F
G
I
R
E
H
A
M
A
A
I
N
N
A
F
A
R
Y
-
G
---
I
F
L
P
F
S
A
T
F
F
I
F
S
E
Y
L
K
P
A
A
R
I
A
A
L
M
K
I
K
H
F
F
I
F
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
Q
L
S
T
F
R
A
M
P
N
F
L
T
F
R
P
A
D
G
V
E
N
V
K
A
W
Q
I
A
-
L
-
N
---
A
-
D
I
P
S
A
F
V
L
S
R
Q
K
L
--
K
A
L
N
---
E
P
----
V
F
G
---
D
V
K
----
N
G
A
Y
L
---
L
K
E
------
S
K
E
A
K
--
F
-
T
L
L
A
S
G
S
E
V
W
L
C
L
E
S
A
N
E
L
E
K
Q
G
F
A
C
N
V
V
S
M
P
C
F
E
L
F
E
K
Q
D
K
A
Y
Q
E
R
L
L
------
K
G
-
E
V
---
I
G
V
E
A
A
H
S
N
E
L
Y
K
F
C
---
H
---
K
---
V
Y
G
I
E
S
F
G
E
S
G
K
D
K
D
V
F
E
R
F
G
F
S
V
S
K
L
V
N
F
I
L
S
K
---
5
PsiBlast_PDB
87.37
42%
-87
- C1 -
4XEU
3
?
A:
[13-671]
------------
R
E
R
A
-
N
A
I
R
A
L
S
M
D
A
V
Q
K
A
N
S
G
H
P
G
A
P
M
G
M
A
D
I
A
E
V
L
-
W
R
D
Y
-
M
Q
H
-
N
P
-
S
N
P
Q
W
A
N
R
D
R
F
V
L
S
N
G
H
G
S
M
L
I
Y
S
L
L
H
L
T
G
Y
D
-
L
G
I
E
D
L
K
N
F
R
Q
L
N
S
R
T
P
G
H
P
E
Y
G
Y
T
A
G
V
E
T
T
T
G
P
L
G
Q
G
I
A
N
A
V
G
M
A
L
A
E
K
V
L
A
A
Q
F
N
R
------
D
---
G
HAV
V
D
---
H
Y
T
Y
A
F
L
G
D
G
C
M
M
E
G
I
S
H
E
V
A
S
L
A
G
T
L
R
L
N
K
L
I
A
F
Y
D
D
N
G
--------
G
W
F
T
D
D
T
P
K
R
F
E
A
Y
G
W
Q
-
V
I
--
R
N
V
-
D
G
H
-
D
--
A
D
E
I
K
T
A
I
D
T
A
R
-
K
-
S
D
-
Q
-
P
T
L
I
C
C
K
T
V
I
G
F
-----------------
A
D
E
I
A
A
T
R
--
A
A
L
G
W
E
H
A
P
F
E
I
P
A
Q
I
Y
A
E
W
D
-
A
K
E
T
-
G
A
A
Q
E
A
E
W
N
K
R
F
A
A
Y
Q
A
A
H
P
E
L
A
A
-
E
L
L
R
R
-
L
-------------
K
GELPA
D
---------
F
----------
A
E
K
A
A
---------
A
---------
Y
V
A
D
V
A
N
K
G
E
T
----
I
A
S
R
K
A
S
Q
N
A
L
N
A
F
G
P
L
L
P
E
L
L
G
G
S
A
D
------
T
L
W
-------------
K
G
C
K
G
V
S
------
A
-
D
D
A
A
---------
G
----
N
Y
V
F
Y
G
V
R
E
F
G
M
S
A
I
M
N
G
V
A
L
H
-
G
-
G
-
F
-
I
P
Y
G
A
T
F
L
I
F
M
E
Y
A
R
N
A
V
R
M
S
A
L
M
K
Q
R
V
L
Y
V
F
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
Q
L
A
S
L
R
L
T
P
N
L
D
T
W
R
P
A
D
A
V
E
S
A
V
A
W
K
H
A
-
I
-
E
R--
A
-
D
G
P
S
A
L
I
F
S
R
Q
N
L
P
H
Q
A
R
D
---
V
A
---
Q
V
A
D
---
I
-
A
----
R
G
G
Y
V
L--
K
D
C
------
E
G
E
P
E
--
L
-
I
L
I
A
T
G
S
E
V
G
L
A
V
Q
A
Y
D
K
L
S
E
Q
G
R
K
V
R
V
V
S
M
P
C
T
S
V
Y
E
Q
Q
D
E
S
Y
K
Q
S
V
L
--
P
VEV
G
--
A
R
---
I
A
I
E
A
A
H
A
D
Y
W
Y
K
Y
V
GLD
G
---
R
---
I
I
G
M
T
S
F
G
E
S
A
P
A
P
A
L
F
E
H
F
G
F
T
L
D
N
V
L
A
V
A
E
E
L
L
--
7
PsiBlast_PDB
85.95
43%
-80
- C1 -
3M49
29
?
A:
[26-690]
--------
S
H
S
I
E
Q
L
S
I
N
T
I
R
T
L
S
I
D
A
I
E
K
A
N
S
G
H
P
G
M
P
M
G
A
A
P
M
A
Y
T
L
-
W
T
-
Q
-
F
M
K
H
N
P
-
N
N
P
T
W
F
N
R
D
R
F
V
L
S
A
G
H
G
S
M
L
L
Y
S
L
L
H
L
S
G
Y
D
-
V
T
M
D
D
L
K
N
F
R
Q
W
G
S
K
T
P
G
H
P
E
Y
G
H
T
A
G
V
D
A
T
T
G
P
L
G
Q
G
I
A
T
A
V
G
M
A
M
A
E
R
H
L
A
A
K
Y
N
R
------
D
---
A
YNI
V
D
---
H
Y
T
Y
A
I
C
G
D
G
D
L
M
E
G
V
S
A
E
A
S
S
L
A
A
H
L
Q
L
G
R
L
V
V
L
Y
D
S
N
D
I
S
L
D
G
D
L
N
R
S
F
S
E
S
V
E
D
R
Y
K
A
Y
G
W
Q
-
V
I
--
R
-
V
E
D
G
N
-
D
--
I
E
A
I
A
K
A
I
E
E
A
K
-
A
-
D
E
-
K
R
P
T
L
I
E
V
R
T
T
I
G
F
G
S
P
N
K
S
G
K
S
A
S
H
G
S
P
L
G
V
E
E
T
K
L
T
K
E
A
Y
A
W
T
A
E
Q
D
F
H
V
A
E
E
V
Y
E
N
F
R
K
T
V
Q
D
V
-
G
E
T
A
Q
A
E
W
N
T
M
L
G
E
Y
A
Q
A
Y
P
E
-
L
A
-
N
E
L
Q
A
-
A
-------------
M
-----
N
---------
G
LLP-------
E
G
W
E
Q
---------
N
---------
L
P
T
--
Y
E
L
G
S
K
----
A
A
T
R
N
S
S
G
A
V
I
N
A
I
A
E
S
V
P
S
F
F
G
G
S
A
D
L
A
G
S
N
K
T
Y
M
-------------
N
N
----
E
------
K
-
D
F
T
R
DDYS-----
G
----
K
N
I
W
Y
G
V
R
E
F
A
M
G
A
A
M
N
G
I
A
L
H
-
G
-
G
-
L
-
K
T
Y
G
G
T
F
F
V
F
S
D
Y
L
R
P
A
I
R
L
A
A
L
M
Q
L
P
V
T
Y
V
F
T
H
D
S
I
A
V
G
E
D
G
P
T
H
E
P
I
E
Q
L
A
A
L
R
A
M
P
N
V
S
V
I
R
P
A
D
G
N
E
S
V
A
A
W
R
L
A
-
L
E
S
---
T
-
N
K
P
T
A
L
V
L
T
R
Q
D
L
--
P
T
L
E
GAK
D
D
---
T
Y
E
K
---
V
-
A
----
K
G
A
Y
V
---
V
S
A
------
S
K
K
E
T
AD
V
-
I
L
L
A
T
G
S
E
V
S
L
A
V
E
A
Q
K
A
L
A
V
D
G
V
D
A
S
V
V
S
M
P
S
M
D
R
F
E
A
Q
T
A
E
Y
K
E
S
V
L
--
P
---
K
--
A
V
TK
R
F
A
I
E
M
G
A
T
F
G
W
H
R
Y
V
GLE
G
---
D
---
V
L
G
I
D
T
F
G
A
S
A
P
G
E
K
I
M
E
E
Y
G
F
T
V
E
N
V
V
R
K
V
K
E
M
L
--
6
PsiBlast_PDB
85.92
43%
-82
- C1 -
3HYL
13
?
A:
[28-690]
----------
S
I
E
Q
L
S
I
N
T
I
R
T
L
S
I
D
A
I
E
K
A
N
S
G
H
P
G
M
P
M
G
A
A
P
M
A
Y
T
L
-
W
T
-
Q
-
F
M
K
H
N
P
-
N
N
P
T
W
F
N
R
D
R
F
V
L
S
A
G
H
G
S
M
L
L
Y
S
L
L
H
L
S
G
Y
D
-
V
T
M
D
D
L
K
N
F
R
Q
W
G
S
K
T
P
G
H
P
E
Y
G
H
T
A
G
V
D
A
T
T
G
P
L
G
Q
G
I
A
T
A
V
G
M
A
M
A
E
R
H
L
A
A
K
Y
N
R
------
D
---
A
YNI
V
D
---
H
Y
T
Y
A
I
C
G
D
G
D
L
M
E
G
V
S
A
E
A
S
S
L
A
A
H
L
Q
L
G
R
L
V
V
L
Y
D
S
N
D
I
S
L
D
G
D
L
N
R
S
F
S
E
S
V
E
D
R
Y
K
A
Y
G
W
Q
-
V
I
--
R
-
V
E
D
G
N
-
D
--
I
E
A
I
A
K
A
I
E
E
A
K
-
A
-
D
E
-
K
R
P
T
L
I
E
V
R
T
T
I
G
F
G
S
P
N
K
S
G
K
S
A
S
H
G
S
P
L
G
V
E
E
T
K
L
T
K
E
A
Y
A
W
T
A
E
Q
D
F
H
V
A
E
E
V
Y
E
N
F
R
K
T
V
Q
D
V
-
G
E
T
A
Q
A
E
W
N
T
M
L
G
E
Y
A
Q
A
Y
P
E
-
L
A
-
N
E
L
Q
A
-
A
-------------
M
-----
N
---------
G
LLP-------
E
G
W
E
Q
---------
N
---------
L
P
T
--
Y
E
L
G
S
K
----
A
A
T
R
N
S
S
G
A
V
I
N
A
I
A
E
S
V
P
S
F
F
G
G
S
A
D
L
A
G
S
N
K
T
Y
M
-------------
N
N
----
E
------
K
-
D
F
T
R
DDYS-----
G
----
K
N
I
W
Y
G
V
R
E
F
A
M
G
A
A
M
N
G
I
A
L
H
-
G
-
G
-
L
-
K
T
Y
G
G
T
F
F
V
F
S
D
Y
L
R
P
A
I
R
L
A
A
L
M
Q
L
P
V
T
Y
V
F
T
H
D
S
I
A
V
G
E
D
G
P
T
H
E
P
I
E
Q
L
A
A
L
R
A
M
P
N
V
S
V
I
R
P
A
D
G
N
E
S
V
A
A
W
R
L
A
-
L
E
S
---
T
-
N
K
P
T
A
L
V
L
T
R
Q
D
L
--
P
T
L
E
GAK
D
D
---
T
Y
E
K
---
V
-
A
----
K
G
A
Y
V
---
V
S
A
------
S
K
K
E
T
AD
V
-
I
L
L
A
T
G
S
E
V
S
L
A
V
E
A
Q
K
A
L
A
V
D
G
V
D
A
S
V
V
S
M
P
S
M
D
R
F
E
A
Q
T
A
E
Y
K
E
S
V
L
--
P
---
K
--
A
V
TK
R
F
A
I
E
M
G
A
T
F
G
W
H
R
Y
V
GLE
G
---
D
---
V
L
G
I
D
T
F
G
A
S
A
P
G
E
K
I
M
E
E
Y
G
F
T
V
E
N
V
V
R
K
V
K
E
M
L
--
60
HHSearch
85.64
45%
-80
- C1 -
3M49
29
?
A:
[26-690]
-------
S
H
S
I
E
Q
L
S
I
-
N
T
I
R
T
L
S
I
D
A
I
E
K
A
N
S
G
H
P
G
M
P
M
G
A
A
P
M
A
Y
T
L
-
W
T
Q
F
-
M
K
H
-
N
P
-
N
N
P
T
W
F
N
R
D
R
F
V
L
S
A
G
H
G
S
M
L
L
Y
S
L
L
H
L
S
G
Y
D
-
V
T
M
D
D
L
K
N
F
R
Q
W
G
S
K
T
P
G
H
P
E
Y
G
H
T
A
G
V
D
A
T
T
G
P
L
G
Q
G
I
A
T
A
V
G
M
A
M
A
E
R
H
L
A
A
K
Y
N
R
DAY---
N
---
I
---
V
D
---
H
Y
T
Y
A
I
C
G
D
G
D
L
M
E
G
V
S
A
E
A
S
S
L
A
A
H
L
Q
L
G
R
L
V
V
L
Y
D
S
N
D
I
S
L
D
G
D
L
N
R
S
F
S
E
S
V
E
D
R
Y
K
A
Y
G
W
Q
-
V
I
--
R
-
V
E
D
G
N
-
D
--
I
E
A
I
A
K
A
I
E
E
A
K
-
A
D
E
K
-
R
-
P
T
L
I
E
V
R
T
T
I
G
F
G
S
P
N
K
S
G
K
S
A
S
H
G
S
P
L
G
V
E
E
T
K
L
T
K
E
A
Y
A
W
T
A
E
Q
D
F
H
V
A
E
E
V
Y
E
N
F
R
K
T
V
Q
D
V
-
G
E
T
A
Q
A
E
W
N
T
M
L
G
-------
E
-
Y
A
-
Q
A
Y
P
E
L
A
-------------
N
-----
E
---------
L
Q
A
A
M
N
GLLPE
G
W
E
Q
N
-------------------
L
P
T
--
Y
E
L
G
S
K
----
A
A
T
R
N
S
S
G
A
V
I
N
A
I
A
E
S
V
P
S
F
F
G
G
S
A
D
L
A
G
S
N
K
T
Y
--------------
M
N
----
N
EKDFTR
D
-
D
-
Y
S
---------
G
----
K
N
I
W
Y
G
V
R
E
F
A
M
G
A
A
M
N
G
I
A
L
H
G
G
---
L
-
K
T
Y
G
G
T
F
F
V
F
S
D
Y
L
R
P
A
I
R
L
A
A
L
M
Q
L
P
V
T
Y
V
F
T
H
D
S
I
A
V
G
E
D
G
P
T
H
E
P
I
E
Q
L
A
A
L
R
A
M
P
N
V
S
V
I
R
P
A
D
G
N
E
S
V
A
A
W
R
L
A
-
L
-
E
S--
T
-
N
K
P
T
A
L
V
L
T
R
Q
D
L
--
P
T
L
E
---
G
A
KDD
T
Y
E
K
---
V
-
A
----
K
G
A
Y
V
---
V
S
A
SK----
K
E
T
A
D
--
V
-
I
L
L
A
T
G
S
E
V
S
L
A
V
E
A
Q
K
A
L
A
V
D
G
V
D
A
S
V
V
S
M
P
S
M
D
R
F
E
A
Q
T
A
E
Y
K
E
S
V
L
PK
A
---
V
T-
K
R
---
F
A
I
E
M
G
A
T
F
G
W
H
R
Y
V
---
G
LEG
D
---
V
L
G
I
D
T
F
G
A
S
A
P
G
E
K
I
M
E
E
Y
G
F
T
V
E
N
V
V
R
K
V
K
E
M
L
--
35
PsiBlast_CBE
84.36
40%
-79
- C1 -
1ITZ
3
TKTC_MAIZE
A:
[10-673]
----
A
A
-
T
G
E
L
L
E
K
S
V
-
N
T
I
R
F
L
A
I
D
A
V
E
K
A
N
S
G
H
P
G
L
P
M
G
C
A
P
M
G
H
V
L
-
Y
D
-
E
V
M
R
Y
-
N
P
-
K
N
P
Y
W
F
N
R
D
R
F
V
L
S
A
G
H
G
C
M
L
Q
Y
A
L
L
H
L
A
G
Y
D
S
V
K
E
E
D
L
K
Q
F
R
Q
W
G
S
R
T
P
G
H
P
E
N
F
E
T
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
A
N
A
V
G
L
A
L
A
E
K
H
L
A
A
R
F
N
K
PDS---
E
---
I
---
V
D
---
H
Y
T
Y
V
I
L
G
D
G
C
Q
M
E
G
I
A
N
E
A
C
S
L
A
G
H
W
G
L
G
K
L
I
A
F
Y
D
D
N
H
I
S
I
D
G
D
T
E
I
A
F
T
E
D
V
S
T
R
F
E
A
L
G
W
H
-
T
I
--
W
-
V
-
K
N
G
-
N
TG
Y
D
D
I
R
A
A
I
K
E
A
K
-
A
V
T
D
-
K
-
P
T
L
I
K
V
T
T
T
I
G
F
G
S
P
N
K
A
N
S
Y
S
V
H
G
S
A
L
G
A
K
E
V
E
A
T
R
Q
N
L
G
W
-
P
Y
D
T
F
F
V
P
E
D
V
K
S
H
W
S
R
-
H
T
P
E
-
G
A
A
L
E
A
D
W
N
A
K
F
A
E
Y
E
---
K
K
-
Y
A
-
D
D
A
A
T
-
L
-------------
K
-----
S
---------
I
----------
I
T
G
E
L
PTGWVDA
L
P
K
---------
Y
T
P
--
E
S
P
G
D
------
A
T
R
N
L
S
Q
Q
C
L
N
A
L
A
N
V
V
P
G
L
I
G
G
S
A
D
L
A
S
S
N
M
T
L
L
-------------
K
M
----
F
------
G
-
D
F
Q
K
---------
D
TAEE
R
N
V
R
F
G
V
R
E
H
G
M
G
A
I
C
N
G
I
A
L
H
-
S
-
P
G
F
-
V
P
Y
C
A
T
F
F
V
F
T
D
Y
M
R
G
A
M
R
I
S
A
L
S
E
A
G
V
I
Y
V
M
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
H
L
V
S
F
R
A
M
P
N
I
L
M
L
R
P
A
D
G
N
E
T
A
G
A
Y
K
V
A
V
L
-
N
---
R
-
K
R
P
S
I
L
A
L
S
R
Q
K
L
--
P
H
L
P
---
G
T
---
S
I
E
G
---
V
-
E
----
K
G
G
Y
T
ISD
N
S
T
------
G
N
K
P
D
--
L
-
I
V
M
G
T
G
S
E
L
E
I
A
A
K
A
A
D
E
L
R
K
E
G
K
T
V
R
V
V
S
F
V
S
W
E
L
F
D
E
Q
S
D
E
Y
K
E
S
V
L
--
P
---
A
--
A
V
TA
R
I
S
I
E
A
G
S
T
L
G
W
Q
K
Y
V
GAQ
G
---
K
---
A
I
G
I
D
K
F
G
A
S
A
P
A
G
T
I
Y
K
E
Y
G
I
T
V
E
S
I
I
A
A
A
K
S
F
---
12
PsiBlast_PDB
84.32
42%
-80
- C1 -
1TRK
3
TKT1_YEAST
A:
[6-664]
-------
D
I
D
K
L
--
A
V
-
S
T
I
R
I
L
A
V
D
T
V
S
K
A
N
S
G
H
P
G
A
P
L
G
M
A
P
A
A
H
V
L
-
W
S
-
Q
-
M
R
M
-
N
P
-
T
N
P
D
W
I
N
R
D
R
F
V
L
S
N
G
H
A
V
A
L
L
Y
S
M
L
H
L
T
G
Y
D
-
L
S
I
E
D
L
K
Q
F
R
Q
L
G
S
R
T
P
G
H
P
E
F
-
E
L
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
S
N
A
V
G
M
A
M
A
Q
A
N
L
A
A
T
Y
N
K
------
P
---
G
---
F
T
L
S
D
N
Y
T
Y
V
F
L
G
D
G
C
L
Q
E
G
I
S
S
E
A
S
S
L
A
G
H
L
K
L
G
N
L
I
A
I
Y
D
D
N
K
I
T
I
D
G
A
T
S
I
S
F
D
E
D
V
A
K
R
Y
E
A
Y
G
W
E
-
V
L
Y
V
E
-
N
-
G
N
E
-
D
--
L
A
G
I
A
K
A
I
A
Q
A
K
-
L
-
S
K
D
K
-
P
T
L
I
K
M
T
T
T
I
G
Y
G
S
L
H
-
A
G
S
H
S
V
H
G
A
P
L
K
A
D
D
V
K
Q
L
K
S
K
F
G
F
N
P
D
K
S
F
V
V
P
Q
E
V
Y
D
H
Y
Q
K
-
T
I
L
K
P
G
V
E
A
N
N
K
W
N
K
L
F
S
-------
E
-
Y
Q
-
K
K
F
P
E
-
L
G
A
E
L
A
R
R
L
S
GQLP
A
-----
N
---------
W
----------
E
S
K
L
P
---------
T
---------
Y
T
A
----
K
D
S
A
----
V
A
T
R
K
L
S
E
T
V
L
E
D
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
P
S
N
L
T
R
W
-------------
K
E
----
A
------
L
-
D
F
Q
P
PSSGSGNYS
G
----
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
-
G
-
A
N
Y
-
K
P
Y
G
G
T
F
L
N
F
V
S
Y
A
A
G
A
V
R
L
S
A
L
S
G
H
P
V
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
-
L
E
S
---
K
-
H
T
P
S
I
I
A
L
S
R
Q
N
L
--
P
Q
L
E
---
G
S
---
S
I
E
S
---
A
-
S
----
K
G
G
Y
V
---
L
Q
D
------
V
A
N
P
D
--
I
-
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
P
D
F
F
T
F
D
K
Q
P
L
E
Y
R
L
S
V
L
--
P
---
D
--
N
V
P
I
-
M
S
V
E
V
L
A
T
T
C
W
G
K
Y
A
---
H
---
Q
---
S
F
G
I
D
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
27
PsiBlast_CBE
84.12
41%
-81
- C1 -
1AY0
3
TKT1_YEAST
B:
[6-664]
-------
D
I
D
K
L
--
A
V
-
S
T
I
R
I
L
A
V
D
T
V
S
K
A
N
S
G
H
P
G
A
P
L
G
M
A
P
A
A
H
V
L
-
W
S
-
Q
-
M
R
M
-
N
P
-
T
N
P
D
W
I
N
R
D
R
F
V
L
S
N
G
H
A
V
A
L
L
Y
S
M
L
H
L
T
G
Y
D
-
L
S
I
E
D
L
K
Q
F
R
Q
L
G
S
R
T
P
G
H
P
E
F
-
E
L
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
S
N
A
V
G
M
A
M
A
Q
A
N
L
A
A
T
Y
N
K
------
P
---
G
---
F
T
LSD
N
Y
T
Y
V
F
L
G
D
G
C
L
Q
E
G
I
S
S
E
A
S
S
L
A
G
H
L
K
L
G
N
L
I
A
I
Y
D
D
N
K
I
T
I
D
G
A
T
S
I
S
F
D
E
D
V
A
K
R
Y
E
A
Y
G
W
E
-
V
L
YV
E
-
N
-
G
N
E
-
D
--
L
A
G
I
A
K
A
I
A
Q
A
K
-
L
-
S
K
D
K
-
P
T
L
I
K
M
T
T
T
I
G
Y
G
S
L
H
-
A
G
S
H
S
V
A
G
A
P
L
K
A
D
D
V
K
Q
L
K
S
K
F
G
F
N
P
D
K
S
F
V
V
P
Q
E
V
Y
D
H
Y
Q
K
-
T
I
L
K
P
G
V
E
A
N
N
K
W
N
K
L
F
S
-------
E
-
Y
Q
-
K
K
F
P
E
-
L
GAELARRLSGQLP
A
-----
N
---------
W
----------
E
S
K
L
P
---------
T
---------
Y
T
A
----
K
D
S
A
----
V
A
T
R
K
L
S
E
T
V
L
E
D
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
P
S
N
L
T
R
W
-------------
K
E
----
A
------
L
-
D
F
Q
P
PSSGSGNYS
G
----
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
-
G
-
A
N
Y
-
K
P
Y
G
G
T
F
L
N
F
V
S
Y
A
A
G
A
V
R
L
S
A
L
S
G
H
P
V
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
-
L
E
S
---
K
-
H
T
P
S
I
I
A
L
S
R
Q
N
L
--
P
Q
L
E
---
G
S
---
S
I
E
S
---
A
-
S
----
K
G
G
Y
V
---
L
Q
D
------
V
A
N
P
D
--
I
-
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
P
D
F
F
T
F
D
K
Q
P
L
E
Y
R
L
S
V
L
--
P
---
D
--
N
V
PI-
M
S
V
E
V
L
A
T
T
C
W
G
K
Y
A
---
H
---
Q
---
S
F
G
I
D
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
33
PsiBlast_CBE
84.09
40%
-79
- C1 -
1ITZ
2
TKTC_MAIZE
C:
[10-673]
----
A
A
-
T
G
E
L
L
E
K
S
V
-
N
T
I
R
F
L
A
I
D
A
V
E
K
A
N
S
G
H
P
G
L
P
M
G
C
A
P
M
G
H
V
L
-
Y
D
-
E
V
M
R
Y
-
N
P
-
K
N
P
Y
W
F
N
R
D
R
F
V
L
S
A
G
H
G
C
M
L
Q
Y
A
L
L
H
L
A
G
Y
D
S
V
K
E
E
D
L
K
Q
F
R
Q
W
G
S
R
T
P
G
H
P
E
N
F
E
T
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
A
N
A
V
G
L
A
L
A
E
K
H
L
A
A
R
F
N
K
PDS---
E
---
I
---
V
D
---
H
Y
T
Y
V
I
L
G
D
G
C
Q
M
E
G
I
A
N
E
A
C
S
L
A
G
H
W
G
L
G
K
L
I
A
F
Y
D
D
N
H
I
S
I
D
G
D
T
E
I
A
F
T
E
D
V
S
T
R
F
E
A
L
G
W
H
-
T
I
--
W
-
V
-
K
N
G
-
N
TG
Y
D
D
I
R
A
A
I
K
E
A
K
-
A
V
T
D
-
K
-
P
T
L
I
K
V
T
T
T
I
G
F
G
S
P
N
K
A
N
S
Y
S
V
H
G
S
A
L
G
A
K
E
V
E
A
T
R
Q
N
L
G
W
-
P
Y
D
T
F
F
V
P
E
D
V
K
S
H
W
S
R
-
H
T
P
E
-
G
A
A
L
E
A
D
W
N
A
K
F
A
EYE---
K
K
-
Y
A
-
D
D
A
A
T
-
L
-------------
K
-----
S
---------
I
----------
I
T
G
E
L
PTGWVDALP
K
---------
Y
T
P
--
E
S
P
G
D
------
A
T
R
N
L
S
Q
Q
C
L
N
A
L
A
N
V
V
P
G
L
I
G
G
S
A
D
L
A
S
S
N
M
T
L
L
-------------
K
M
----
F
------
G
-
D
F
Q
K
---------
D
TAEE
R
N
V
R
F
G
V
R
E
H
G
M
G
A
I
C
N
G
I
A
L
H
-
S
-
P
G
F
-
V
P
Y
C
A
T
F
F
V
F
T
D
Y
M
R
G
A
M
R
I
S
A
L
S
E
A
G
V
I
Y
V
M
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
H
L
V
S
F
R
A
M
P
N
I
L
M
L
R
P
A
D
G
N
E
T
A
G
A
Y
K
V
A
V
L
-
N
---
R
-
K
R
P
S
I
L
A
L
S
R
Q
K
L
--
P
H
L
P
---
G
T
---
S
I
E
G
---
V
-
E
----
K
G
G
Y
T
ISD
N
S
T
------
G
N
K
P
D
--
L
-
I
V
M
G
T
G
S
E
L
E
I
A
A
K
A
A
D
E
L
R
K
E
G
K
T
V
R
V
V
S
F
V
S
W
E
L
F
D
E
Q
S
D
E
Y
K
E
S
V
L
--
P
---
A
--
A
V
TAR
I
S
I
E
A
G
S
T
L
G
W
Q
K
Y
V
GAQ
G
---
K
---
A
I
G
I
D
K
F
G
A
S
A
P
A
G
T
I
Y
K
E
Y
G
I
T
V
E
S
I
I
A
A
A
K
S
F
---
61
HHSearch
83.83
38%
-76
- C1 -
3RIM
3
TKT_MYCTU
A:
[19-699]
-------
W
T
E
I
D
S
A
A
V
-
D
T
I
R
V
L
A
A
D
A
V
Q
K
V
G
N
G
H
P
G
T
A
M
S
L
A
P
L
A
Y
T
L
-
F
Q
R
T
-
M
R
H
-
D
P
-
S
D
T
H
W
L
G
R
D
R
F
V
L
S
A
G
H
S
S
L
T
L
Y
I
Q
L
Y
L
G
G
F
G
-
L
E
L
S
D
I
E
S
L
R
T
W
G
S
K
T
P
G
H
P
E
F
R
H
T
P
G
V
E
I
T
T
G
P
L
G
Q
G
L
A
S
A
V
G
M
A
M
A
S
R
Y
E
R
G
L
F
D
P
DAEPGA
S
---
P
---
F
D
---
H
Y
I
Y
V
I
A
S
D
G
D
I
E
E
G
V
T
S
E
A
S
S
L
A
A
V
Q
Q
L
G
N
L
I
V
F
Y
D
R
N
Q
I
S
I
E
D
D
T
N
I
A
L
C
E
D
T
A
A
R
Y
R
A
Y
G
W
H
-
V
Q
--
E
-
V
E
G
G
E
-
N
--
V
V
G
I
E
E
A
I
A
N
A
Q
-
A
V
T
D
-
R
-
P
S
F
I
A
L
R
T
V
I
G
Y
P
A
P
N
L
M
D
T
G
K
A
H
G
A
A
L
G
D
D
E
V
A
A
V
K
K
I
V
G
F
D
P
D
K
T
F
Q
V
R
E
D
V
L
T
H
T
R
G
-
L
V
A
R
-
G
K
Q
A
H
E
R
W
Q
L
E
F
D
-------
A
-
W
A
-
R
R
E
P
E
R
K
-------------
A
-----
L
---------
L
D
R
L
L
A
QKLPD
G
W
D
A
D
-------------------
L
P
H
--
W
E
P
G
S
K
A
---
L
A
T
R
A
A
S
G
A
V
L
S
A
L
G
P
K
L
P
E
L
W
G
G
S
A
D
L
A
G
S
N
N
T
T
I
KG
A
D
S
F
G
PPSIST
K
E
----
Y
------
T
A
H
-
W
Y
---------
G
----
R
T
L
H
F
G
V
R
E
H
A
M
G
A
I
L
S
G
I
V
L
H
-
G
-
P
-
T
-
R
A
Y
G
G
T
F
L
Q
F
S
D
Y
M
R
P
A
V
R
L
A
A
L
M
D
I
D
T
I
Y
V
W
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
H
L
S
A
L
R
A
I
P
R
L
S
V
V
R
P
A
D
A
N
E
T
A
Y
A
W
R
T
I
-
L
-
A
RRN
G
-
S
G
P
V
G
L
I
L
T
R
Q
G
V
--
P
V
L
D
---
G
T
---
D
A
E
G
---
V
-
A
----
R
G
G
Y
V
---
L
S
D
AGGLQP
G
E
E
P
D
--
V
-
I
L
I
A
T
G
S
E
V
Q
L
A
V
A
A
Q
T
L
L
A
D
N
D
I
L
A
R
V
V
S
M
P
C
L
E
W
F
E
A
Q
P
Y
E
Y
R
D
A
V
L
P-
P
---
T
VS
A
R
---
V
A
V
E
A
G
V
A
Q
C
W
H
Q
L
V
---
G
DTG
E
---
I
V
S
I
E
H
Y
G
E
S
A
D
H
K
T
L
F
R
E
Y
G
F
T
A
E
A
V
A
A
A
A
E
R
A
L
D
-
32
PsiBlast_CBE
83.62
39%
-78
- C1 -
1QGD
4
TKT1_ECOLI
A:
[4-662]
------------
K
E
L
A
-
N
A
I
R
A
L
S
M
D
A
V
Q
K
A
K
S
G
H
P
G
A
P
M
G
M
A
D
I
A
E
V
L
-
W
R
-
D
F
L
K
H
-
N
P
-
Q
N
P
S
W
A
D
R
D
R
F
V
L
S
N
G
H
G
S
M
L
I
Y
S
L
L
H
L
T
G
Y
D
-
L
P
M
E
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L
K
N
F
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L
H
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K
T
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G
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A
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G
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N
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PGH---
D
---
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---
V
D
---
H
Y
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A
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M
G
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-
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-------------
A
-----
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GEMPS
D
F
D
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K
---------
A
---------
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E
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--
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L
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A
N
PAK
I
A
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R
K
A
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N
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P
L
L
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F
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A
D
L
A
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S
N
L
T
L
W
-------------
S
G
----
S
KAI---
N
-
E
D
A
A
---------
G
----
N
Y
I
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Y
G
V
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F
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--
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---
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---
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E
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L
A
N
I
-
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----
R
G
G
Y
V
L--
K
D
C
------
A
G
Q
P
E
--
L
-
I
F
I
A
T
G
S
E
V
E
L
A
V
A
A
Y
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K
L
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K
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V
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A
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--
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---
K
--
A
V
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A
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K
Y
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GLN
G
---
A
---
I
V
G
M
T
T
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G
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A
P
A
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L
L
F
E
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F
G
F
T
V
D
N
V
V
A
K
A
K
E
L
L
--
26
PsiBlast_CBE
83.57
42%
-78
- C1 -
1GPU
3
TKT1_YEAST
B:
[6-664]
-------
D
I
D
K
L
--
A
V
-
S
T
I
R
I
L
A
V
D
T
V
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K
A
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H
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G
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L
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A
A
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V
L
-
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-
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M
-
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D
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---
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---
F
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LSD
N
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--
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-------
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GAELARRLSGQLP
A
-----
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---------
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----------
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---------
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---------
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----
K
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----
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A
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S
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L
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R
W
-------------
K
E
----
A
------
L
-
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F
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P
PSSGSGNYS
G
----
R
Y
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G
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H
A
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G
A
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M
N
G
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-
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-
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A
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---
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---
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---
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-
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----
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---
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------
V
A
N
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D
--
I
-
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A
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G
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--
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---
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--
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PI-
M
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V
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L
A
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---
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---
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T
P
E
G
V
A
E
R
A
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K
T
I
A
F
14
PsiBlast_PDB
83.55
42%
-77
- C1 -
1GPU
3
TKT1_YEAST
A:
[6-664]
-------
D
I
D
K
L
--
A
V
-
S
T
I
R
I
L
A
V
D
T
V
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K
A
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G
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G
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A
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PSSGSGNYS
G
----
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Y
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K
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S
I
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S
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Q
N
L
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L
E
---
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S
---
S
I
E
S
---
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-
S
----
K
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G
Y
V
---
L
Q
D
------
V
A
N
P
D
--
I
-
I
L
V
A
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G
S
E
V
S
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T
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A
A
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L
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---
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I
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L
A
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Y
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---
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A
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P
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A
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A
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K
T
I
A
F
34
PsiBlast_CBE
83.52
40%
-77
- C1 -
1ITZ
3
TKTC_MAIZE
B:
[10-673]
----
A
A
-
T
G
E
L
L
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S
V
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N
T
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R
F
L
A
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D
Y
M
R
G
A
M
R
I
S
A
L
S
E
A
G
V
I
Y
V
M
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
H
L
V
S
F
R
A
M
P
N
I
L
M
L
R
P
A
D
G
N
E
T
A
G
A
Y
K
V
A
V
L
-
N
---
R
-
K
R
P
S
I
L
A
L
S
R
Q
K
L
--
P
H
L
P
---
G
T
---
S
I
E
G
---
V
-
E
----
K
G
G
Y
T
ISD
N
S
T
------
G
N
K
P
D
--
L
-
I
V
M
G
T
G
S
E
L
E
I
A
A
K
A
A
D
E
L
R
K
E
G
K
T
V
R
V
V
S
F
V
S
W
E
L
F
D
E
Q
S
D
E
Y
K
E
S
V
L
--
P
---
A
--
A
V
TAR
I
S
I
E
A
G
S
T
L
G
W
Q
K
Y
V
GAQ
G
---
K
---
A
I
G
I
D
K
F
G
A
S
A
P
A
G
T
I
Y
K
E
Y
G
I
T
V
E
S
I
I
A
A
A
K
S
F
---
58
HHSearch
83.50
43%
-78
- C1 -
1GPU
3
TKT1_YEAST
A:
[4-665]
-------
F
T
D
I
D
K
L
A
V
-
S
T
I
R
I
L
A
V
D
T
V
S
K
A
N
S
G
H
P
G
A
P
L
G
M
A
P
A
A
H
V
L
-
W
S
-
Q
-
M
R
M
-
N
P
-
T
N
P
D
W
I
N
R
D
R
F
V
L
S
N
G
H
A
V
A
L
L
Y
S
M
L
H
L
T
G
Y
D
-
L
S
I
E
D
L
K
Q
F
R
Q
L
G
S
R
T
P
G
H
P
E
F
-
E
L
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
S
N
A
V
G
M
A
M
A
Q
A
N
L
A
A
T
Y
N
K
------
P
GFT
L
---
S
D
---
N
Y
T
Y
V
F
L
G
D
G
C
L
Q
E
G
I
S
S
E
A
S
S
L
A
G
H
L
K
L
G
N
L
I
A
I
Y
D
D
N
K
I
T
I
D
G
A
T
S
I
S
F
D
E
D
V
A
K
R
Y
E
A
Y
G
W
E
-
V
L
--
Y
-
V
E
N
G
N
E
D
--
L
A
G
I
A
K
A
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A
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A
K
-
L
S
K
D
-
K
-
P
T
L
I
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M
T
T
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I
G
Y
G
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L
H
-
A
G
S
H
S
V
H
G
A
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L
K
A
D
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L
K
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K
F
G
F
N
P
D
K
S
F
V
V
P
Q
E
V
Y
D
H
Y
Q
K
T
I
L
K
P
-
G
V
E
A
N
N
K
W
N
K
L
F
S
-------
E
-
Y
Q
-
K
K
F
P
E
L
G
-------------
A
-----
E
L
A
R
R
L
S
GQL
P
A---------
N
W
E
S
K
-------------------
L
P
T
--
Y
T
A
K
D
S
A---
V
A
T
R
K
L
S
E
T
V
L
E
D
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
P
S
N
L
T
R
W
KEALDFQPP----
S
S
----
G
S-----
G
-
N
-
Y
S
---------
G
----
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
-
G
A
N
-
Y
-
K
P
Y
G
G
T
F
L
N
F
V
S
Y
A
A
G
A
V
R
L
S
A
L
S
G
H
P
V
I
W
V
A
T
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D
S
I
G
V
G
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D
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I
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T
L
A
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F
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L
P
N
I
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V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
-
L
-
E
---
S
K
H
T
P
S
I
I
A
L
S
R
Q
N
L
--
P
Q
L
E
---
G
S
---
S
I
E
S
---
A
-
S
----
K
G
G
Y
V
---
L
Q
D
------
V
A
N
P
D
--
I
-
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
P
D
F
F
T
F
D
K
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L
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Y
R
L
S
V
L
--
P
D--
N
V
-
P
I
---
M
S
V
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V
L
A
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T
C
W
G
K
Y
A
---
H
---
Q
---
S
F
G
I
D
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
24
PsiBlast_CBE
83.46
42%
-79
- C1 -
1TRK
3
TKT1_YEAST
B:
[6-664]
-------
D
I
D
K
L
--
A
V
-
S
T
I
R
I
L
A
V
D
T
V
S
K
A
N
S
G
H
P
G
A
P
L
G
M
A
P
A
A
H
V
L
-
W
S
-
Q
-
M
R
M
-
N
P
-
T
N
P
D
W
I
N
R
D
R
F
V
L
S
N
G
H
A
V
A
L
L
Y
S
M
L
H
L
T
G
Y
D
-
L
S
I
E
D
L
K
Q
F
R
Q
L
G
S
R
T
P
G
H
P
E
F
-
E
L
P
G
V
E
V
T
T
G
P
L
G
Q
G
I
S
N
A
V
G
M
A
M
A
Q
A
N
L
A
A
T
Y
N
K
------
P
---
G
---
F
T
LSD
N
Y
T
Y
V
F
L
G
D
G
C
L
Q
E
G
I
S
S
E
A
S
S
L
A
G
H
L
K
L
G
N
L
I
A
I
Y
D
D
N
K
I
T
I
D
G
A
T
S
I
S
F
D
E
D
V
A
K
R
Y
E
A
Y
G
W
E
-
V
L
YV
E
-
N
-
G
N
E
-
D
--
L
A
G
I
A
K
A
I
A
Q
A
K
-
L
-
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K
D
K
-
P
T
L
I
K
M
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T
T
I
G
Y
G
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L
H
-
A
G
S
H
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H
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A
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F
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N
N
K
W
N
K
L
F
S
-------
E
-
Y
Q
-
K
K
F
P
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-
L
GAELARRLSGQLP
A
-----
N
---------
W
----------
E
S
K
L
P
---------
T
---------
Y
T
A
----
K
D
S
A
----
V
A
T
R
K
L
S
E
T
V
L
E
D
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
P
S
N
L
T
R
W
-------------
K
E
----
A
------
L
-
D
F
Q
P
PSSGSGNYS
G
----
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
-
G
-
A
N
Y
-
K
P
Y
G
G
T
F
L
N
F
V
S
Y
A
A
G
A
V
R
L
S
A
L
S
G
H
P
V
I
W
V
A
T
H
D
S
I
G
V
G
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D
G
P
T
H
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P
I
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T
L
A
H
F
R
S
L
P
N
I
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V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
-
L
E
S
---
K
-
H
T
P
S
I
I
A
L
S
R
Q
N
L
--
P
Q
L
E
---
G
S
---
S
I
E
S
---
A
-
S
----
K
G
G
Y
V
---
L
Q
D
------
V
A
N
P
D
--
I
-
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
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N
I
K
A
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V
S
L
P
D
F
F
T
F
D
K
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L
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Y
R
L
S
V
L
--
P
---
D
--
N
V
PI-
M
S
V
E
V
L
A
T
T
C
W
G
K
Y
A
---
H
---
Q
---
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F
G
I
D
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F
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A
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G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
17
PsiBlast_PDB
82.43
42%
-79
- C1 -
4C7X
2
?
A:
[29-675]
-----------------
N
T
L
R
T
L
S
I
D
A
I
Q
R
A
N
S
G
H
P
G
L
P
M
G
A
A
P
M
A
Y
V
L
W
T
R
-
H
-
L
K
I
-
N
P
K
T
H
M
N
W
V
N
R
D
R
F
V
L
S
A
G
H
G
S
A
L
L
Y
S
L
A
H
L
A
G
Y
D
-
V
S
M
D
D
L
K
N
F
R
E
W
K
S
N
T
P
G
H
P
E
Y
G
C
T
D
G
V
E
A
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T
G
P
L
G
Q
G
I
S
M
A
V
G
M
A
M
A
E
A
H
L
G
K
K
F
N
R
------
E
---
G
YPV
M
D
---
H
Y
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Y
A
L
I
G
D
G
D
L
M
E
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A
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D
S
N
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N
V
G
A
R
F
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A
Y
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W
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Y
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--
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L
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D
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A
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A
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Y
N
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K
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N
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M
F
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------
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K
K
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D
L
-
A
-------------
Q
-----
K
---------
F
----------
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---------
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KVPNTLGDI
L
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--
Y
G
E
D
D
S
----
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A
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-------------
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----
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------
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G
----
R
N
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F
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D
Y
L
K
A
A
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A
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--
D
G
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F
E
A
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N
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--
P
PEL
K
--
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R
---
M
T
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G
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A
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---
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---
D
H
G
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L
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N
I
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D
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Y
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----