@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0387: (2015-12-15 )
MRGLERESHFTLNENAMFFECAYSCDNALFLQLDDRSFFITDSRYTQEAKESLQPKKGVLVEVIESSDLVQSAIDLITKSSVKKLFFDPNQVNLQTYKRLDSAVGNKVVLEGVPSYHRQKRIIKNEHEIQLLKKSQALNVEAFENFAEYVKKIFDEKESLSERYLQHKVKDFLTKEGVYDLSFEPILALNANASKPHALPSAKDFLKADHSILLDMGIKYERYCSDRTRTAFFDPKDFVFKREQSFKDKERQKIYDIVKEAQEKAISGIRAGMTGKEADSLARGVISDYGYGQYFTHSTGHGIGLDIHELPYISSRSETILEEGMVFSVEPGIYIPGFFGVRIEDLVVIKNSRAELL
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10....-----....20....-..------.--.30...----.....40......-..50....-.-------..-.60........70........80---.----.----......--------.-90........100...----....110.....--..120.......130.......140.......150.......160.......170...-.-...180.......190.......200..--.....210.......220.......230..-......240.......250.-......260.......270.......280.......----290------........300..--.....310-....--...320.......330.....-..340.......350.....---------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRGLERES
H
F
TLNEN-----
A
M
F
F
E
C
AYSC-D
N
------
A
--
L
F
L
Q
LD----D
R
S
F
F
I
TDSR
Y
T
Q
-
E
A
K
E
SLQP-K-------K
G
-
V
L
V
E
VIE
S
S
D
L
V
Q
S
A
I
D
L
I
T
K
S
----
S
----
V
----
K
K
LFFD--------P-NQ
V
N
L
Q
T
Y
K
R
L
D
S
AVG----
N
K
V
V
LEGVP
S
Y
H
--
R
Q
K
R
I
IK
N
E
H
E
I
Q
L
L
K
KSQAL
N
V
E
A
F
E
N
F
A
E
Y
V
K
K
I
FD
E
K
E
S
L
S
E
R
Y
L
Q
H
K
V
K
D
F
L
T
K-E-GVYDLSF
E
P
I
L
A
LNANASKPHALP
S
A
K
D
--
F
L
K
A
D
H
S
I
L
L
D
MGI
K
Y
E
R
Y
CSDRT
R
T
-
A
FF-D
P
K
D
F
V
F
K
R
E
QSF
K
D
K
E
R
Q
K
-
I
Y
D
I
V
K
E
A
Q
E
K
A
I
S
G
I
RAGMTG
K
E
A
D
S
L
A
R
G
V
I
S
DY----GY-------GQ
Y
F
THSTGHGIG--LDIHELPY-ISS
R
--
S
E
T
I
L
EEG
M
V
F
SVEP
G
I
Y
IPG-FFG
V
R
I
E
D
L
V
V
I
KNSRAELL---------------------------------------------------------------------
49
HHSearch
98.53
33%
-71
* C1 *
3Q6D
2
?
A:
[14-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
-----
S
R
R
Y
M
A
N
F
T
G
-
T
A
------
G
V
-
V
L
I
S
K
-----
K
R
A
Q
F
I
T
D
F
R
Y
V
E
-
Q
A
S
K
Q
A
V
G
-
Y
-------
E
I
-
V
--
Q
H
A
G
L
--
I
I
D
E
V
A
K
Q
V
K
E
L
----
G
----
I
----
Q
K
L
G
F
E
--------
Q
-
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-----
A
E
F
I
P
-
T
S
G
L
V
--
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
------
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
S
E
K
---
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
-
I
A
V
-
G
E
-----------
P
S
D
K
L
K
E
-
I
Y
N
I
V
L
E
A
Q
L
R
G
V
N
G
I
K
A
G
L
T
G
R
E
A
D
A
L
T
R
D
Y
I
T
E
K
----
G
Y
-------
G
E
Y
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
G
-
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
-
I
G
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
---------------------------------------------------------------------
22
PsiBlast_CBE
96.41
35%
-76
- C1 -
3Q6D
1
?
C:
[26-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
H
-----
S
R
R
Y
M
A
N
F
T
G
-
T
A
------
G
--
V
V
L
I
S
K
----
K
R
A
Q
F
I
T
D
F
R
Y
V
E
-
Q
A
S
------
K
-------
Q
A
-
V
G
Y
E
I
V
Q
H
A
G
L
I
---
I
D
E
V
A
K
Q
VKEL
G
----
I
----
Q
K
L
G
F
E
--------
Q
-
D
T
L
T
Y
S
S
Y
----
S
A
H
K
----
E
A
I
D
A
E
F
I
P
T
S
G
LV
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
------
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
S
E
K
V
--
I
E
T
G
D
F
-
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
G
-
E
P
S
D
------------
K
L
K
E
-
I
Y
N
I
V
L
E
A
Q
L
R
G
V
N
G
I
K
A
G
L
T
G
R
E
A
D
A
L
T
R
D
Y
I
T
E
K
----
G
Y
-------
G
E
Y
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
G
-
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
-
I
G
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
---------------------------------------------------------------------
1
PsiBlast_PDB
96.06
35%
-78
- C1 -
3Q6D
2
?
A:
[26-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
H
-----
S
R
R
Y
M
A
N
F
T
G
-
T
A
------
G
--
V
V
L
I
S
K
----
K
R
A
Q
F
I
T
D
F
R
Y
V
E
-
Q
A
S
------
K
-------
Q
A
-
V
G
Y
E
I
V
Q
H
A
G
L
I
---
I
D
E
V
A
K
Q
V
K
E
L
G
----
I
----
Q
K
L
G
F
E
--------
Q
-
D
T
L
T
Y
S
S
Y
----
S
A
H
K
----
E
A
I
D
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
------
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
S
E
K
V
--
I
E
T
G
D
F
-
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
G
-
E
P
S
D
------------
K
L
K
E
-
I
Y
N
I
V
L
E
A
Q
L
R
G
V
N
G
I
K
A
G
L
T
G
R
E
A
D
A
L
T
R
D
Y
I
T
E
K
----
G
Y
-------
G
E
Y
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
G
-
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
-
I
G
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
---------------------------------------------------------------------
21
PsiBlast_CBE
95.27
35%
-77
- C1 -
3Q6D
1
?
D:
[26-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
H
-----
S
R
R
Y
M
A
N
F
T
G
-
T
A
------
G
--
V
V
L
I
S
K
----
K
R
A
Q
F
I
T
D
F
R
Y
V
E
-
Q
A
S
------
K
-------
Q
A
-
V
G
Y
E
I
V
Q
H
A
G
L
I
---
I
D
E
V
A
K
Q
VKEL
G
----
I
----
Q
K
L
G
F
E
--------
Q
-
D
T
L
T
Y
S
S
Y
----
S
A
H
K
----
E
A
I
D
A
E
F
I
P
T
S
G
LV
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
------
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
S
E
K
V
--
I
E
T
G
D
F
-
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
G
-
E
P
S
D
------------
K
L
K
E
-
I
Y
N
I
V
L
E
A
Q
L
R
G
V
N
G
I
K
A
G
L
T
G
R
E
A
D
A
L
T
R
D
Y
I
T
E
K
----
G
Y
-------
G
E
Y
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
G
-
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
-
I
G
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
---------------------------------------------------------------------
23
PsiBlast_CBE
94.54
35%
-78
- C1 -
3Q6D
1
?
B:
[26-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
H
-----
S
R
R
Y
M
A
N
F
T
G
-
T
A
------
G
--
V
V
L
I
S
K
----
K
R
A
Q
F
I
T
D
F
R
Y
V
E
-
Q
A
S
------
K
-------
Q
A
-
V
G
Y
E
I
V
Q
H
A
G
L
I
---
I
D
E
V
A
K
Q
VKEL
G
----
I
----
Q
K
L
G
F
E
--------
Q
-
D
T
L
T
Y
S
S
Y
----
S
A
H
K
----
E
A
I
D
A
E
F
I
P
T
S
G
LV
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
------
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
-
G
A
T
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
S
E
K
V
--
I
E
T
G
D
F
-
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
G
-
E
P
S
D
------------
K
L
K
E
-
I
Y
N
I
V
L
E
A
Q
L
R
G
V
N
G
I
K
A
G
L
T
G
R
E
A
D
A
L
T
R
D
Y
I
T
E
K
----
G
Y
-------
G
E
Y
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
G
-
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
P
G
-
I
G
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
---------------------------------------------------------------------
24
PsiBlast_CBE
93.54
33%
-72
- C1 -
2ZSG
2
?
B:
[37-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
G
-
S
F
------
S
--
I
I
L
I
S
E
----
N
T
R
L
L
I
T
D
S
R
Y
T
V
-
Q
A
K
Q
E
T
D
F
-
E
------------
V
R
E
V
K
G
G
D
F
I
D
V
L
K
K
T
V
N
D
L
----
K
----
I
----
K
T
I
A
L
E
--------
E
-
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
----
D
R
K
F
I
-
G
I
D
D
E
V
--
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
---
L
E
T
V
Q
Q
I
---
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
S
D
K
V
--
V
E
R
G
D
-
V
I
V
I
D
F
G
A
T
Y
E
N
Y
C
A
D
I
T
R
V
V
S
I
G
-
E
P
S
D
------------
E
V
K
E
-
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
G
V
T
G
K
L
L
D
S
V
A
R
E
F
I
R
E
K
----
G
Y
-------
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
A
-
I
S
F
R
--
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
-
K
F
G
I
R
I
E
E
D
V
V
L
K
E
Q
G
C
E
I
L
---------------------------------------------------------------------
48
HHSearch
92.92
33%
-71
- C1 -
2ZSG
8
?
A:
[11-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
NSA
R
A
S
S
V
Y
F
S
G
F
T
G
-
S
F
------
S
--
I
I
L
I
S
E
----
N
T
R
L
L
I
T
D
S
R
Y
T
V
-
Q
A
K
Q
E
T
D
--
F
-------
E
V
-
R
--
E
V
--------
D
F
I
D
V
L
K
K
T
----
V
N
D
L
K
I
----
K
T
I
A
L
E
--------
E
-
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
----
D
R
K
F
I
G
-
I
D
D
E
V
--
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
I
R
A
------
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
S
D
K
---
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
N
Y
C
A
D
I
T
R
V
-
V
S
I
-
G
E
-----------
P
S
D
E
V
K
E
-
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
G
V
T
G
K
L
L
D
S
V
A
R
E
F
I
R
E
K
----
G
Y
-------
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
A
-
I
S
F
R
--
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
-
K
F
G
I
R
I
E
E
D
V
V
L
K
E
Q
G
C
E
I
L
---------------------------------------------------------------------
2
PsiBlast_PDB
91.30
33%
-72
- C1 -
2ZSG
8
?
A:
[37-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
G
-
S
F
------
S
--
I
I
L
I
S
E
----
N
T
R
L
L
I
T
D
S
R
Y
T
V
-
Q
A
K
Q
E
T
D
F
-
E
------------
V
R
E
V
---
D
F
I
D
V
L
K
K
T
V
N
D
L
----
K
----
I
----
K
T
I
A
L
E
--------
E
-
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
----
D
R
K
F
I
-
G
I
D
D
E
V
--
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
---
L
E
T
V
Q
Q
I
---
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
-
G
A
E
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
S
D
K
V
--
V
E
R
G
D
-
V
I
V
I
D
F
G
A
T
Y
E
N
Y
C
A
D
I
T
R
V
V
S
I
G
-
E
P
S
D
------------
E
V
K
E
-
V
H
S
I
V
L
E
A
Q
E
R
A
L
K
I
A
K
A
G
V
T
G
K
L
L
D
S
V
A
R
E
F
I
R
E
K
----
G
Y
-------
G
E
F
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
A
-
I
S
F
R
--
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
E
G
-
K
F
G
I
R
I
E
E
D
V
V
L
K
E
Q
G
C
E
I
L
---------------------------------------------------------------------
70
Fugue
90.91
30%
-63
- C1 -
1WN1
2
?
A:
[1-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
Y
L
T
G
L
R
L
-
H
E
VGER
L
A
I
--
L
A
V
S
A
E
----
G
D
Y
R
F
L
A
P
S
L
Y
E
N
-
V
V
N
N
F
---------------
P
A
T
F
W
H
D
G
E
N
P
Y
A
K
L
R
E
I
L
E
E
L
----
G
----
I
----
S
K
G
R
I
L
--------
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
------
G
K
F
T
F
Q
P
L
S
S
L
I
--
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
------
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
--
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
G
E
R
K
--
I
R
K
G
D
-
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
-
I
G
L
-
G
E
L
D
-----------
E
R
L
V
K
-
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
G
I
K
A
K
D
V
D
S
R
A
R
E
V
I
S
K
A
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
Y
-
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
-
L
G
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
TKAERELIIL-----------------------------------------------------------
69
Fugue
89.66
30%
-75
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
-----
N
V
Y
Y
F
S
G
T
S
P
L
G
G
------
G
--
Y
I
I
V
D
G
----
D
E
A
T
L
Y
V
P
E
L
E
Y
E
-
M
A
K
E
E
S
K
L
-
P
------------
V
V
K
F
K
K
F
D
E
I
Y
E
I
L
-----
K
----
N
----
T
----
E
T
L
G
I
E
--------
G
-
T
L
-
S
Y
S
M
V
E
N
F
K
E
K
S
V
----
K
E
F
K
K
--
I
D
D
V
I
--
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
------
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
S
D
K
R
---
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
H
Y
N
S
D
I
T
R
T
-
I
V
V
-
G
S
P
N
-----------
E
K
Q
R
E
-
I
Y
E
I
V
L
E
A
Q
K
R
A
V
E
A
A
K
P
G
M
T
A
K
E
L
D
S
I
A
R
E
I
I
K
E
Y
----
G
Y
-------
G
D
Y
F
I
H
S
L
G
H
G
V
G
--
L
E
I
H
E
W
P
R
-
I
S
Q
Y
--
D
E
T
V
L
K
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
-
L
G
G
V
R
I
E
D
T
V
L
I
T
E
N
G
A
K
R
L
TKTER----------------------------------------------------------------
50
HHSearch
88.95
30%
-72
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[15-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
-----
N
V
Y
Y
I
S
G
A
S
P
-
L
A
------
G
G
Y
I
L
I
T
-
G
----
E
S
A
T
L
Y
V
P
E
L
E
Y
E
-
M
A
K
E
E
S
N
I
-
P
--------
V
-
E
--
K
F
K
K
M
----
D
E
F
Y
K
A
L
E
G
----------
I
----
K
S
L
G
I
E
--------
S
--
S
L
P
Y
G
F
I
E
E
L
K
K
K
A
N
----
I
K
E
F
K
K
-
V
D
D
V
I
--
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
------
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
S
D
K
---
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
-
I
V
V
-
G
S
-----------
P
N
E
K
Q
K
E
-
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
G
I
T
A
K
E
L
D
S
I
A
R
N
I
I
A
E
Y
----
G
Y
-------
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
R
-
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
-
I
G
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
---------------------------------------------------------------------
51
HHSearch
88.11
29%
-62
- C1 -
1WN1
2
?
A:
[10-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
-----
N
L
Y
Y
L
T
G
L
R
L
-
H
E
VGER
L
A
I
--
L
A
V
S
A
E
----
G
D
Y
R
F
L
A
P
S
L
Y
E
N
-
V
V
N
N
F
------------
P
A
-
T
--
F
W
H
D
G
E
N
P
Y
A
K
L
R
E
I
L
E
E
L
----
G
IS--
K
----
G
R
I
L
I
E
--------
D
--
T
M
R
A
D
W
L
I
G
I
M
-
K
L
G
----
K
F
T
F
Q
P
-
L
S
S
L
I
--
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
------
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
-
S
D
-
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
G
E
R
---
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
-
I
G
L
-
G
E
-----------
L
D
E
R
L
V
K
-
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
G
I
K
A
K
D
V
D
S
R
A
R
E
V
I
S
K
A
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
Y
-
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
-
L
G
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
---------------------------------------------------------------------
6
PsiBlast_PDB
84.17
35%
-53
- C1 -
2HOW
-
?
A:
[86-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
E
E
L
G
I
S
--------
K
-
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
--
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
------
D
L
I
G
M
K
E
R
E
L
A
L
K
I
-
E
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
G
E
R
K
--
I
R
K
G
D
-
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
-
I
G
L
-
G
E
L
D
-----------
E
R
L
V
K
-
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
G
I
K
A
K
D
V
D
S
R
A
R
E
V
I
S
K
A
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
Y
-
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
-
L
G
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
---------------------------------------------------------------------
5
PsiBlast_PDB
84.00
35%
-53
- C1 -
1WN1
2
?
A:
[86-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
E
E
L
G
I
S
--------
K
-
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
--
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
------
D
L
I
G
M
K
E
R
E
L
A
L
K
I
-
E
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
G
E
R
K
--
I
R
K
G
D
-
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
-
I
G
L
-
G
E
L
D
-----------
E
R
L
V
K
-
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
G
I
K
A
K
D
V
D
S
R
A
R
E
V
I
S
K
A
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
Y
-
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
-
L
G
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
---------------------------------------------------------------------
26
PsiBlast_CBE
83.07
35%
-53
- C1 -
1WN1
2
?
B:
[86-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
E
E
L
G
I
S
--------
K
-
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
IMKL
G
K
F
T
F
Q
P
L
S
S
L
I
--
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
------
D
L
I
G
M
K
E
R
E
L
A
L
K
I
-
E
L
L
I
R
-
E
-
L
S
D
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
G
E
R
K
--
I
R
K
G
D
-
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
-
I
G
L
-
G
E
L
D
-----------
E
R
L
V
K
-
I
Y
E
V
V
K
D
A
Q
E
S
A
F
K
A
V
R
E
G
I
K
A
K
D
V
D
S
R
A
R
E
V
I
S
K
A
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
Y
-
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
P
G
-
L
G
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
---------------------------------------------------------------------
7
PsiBlast_PDB
81.70
36%
-68
- C1 -
1WY2
5
PEPQ_PYRHO
A:
[108-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
N
I
K
E
F
K
K
V
D
D
V
I
-------------------
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
------
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
S
D
K
R
--
I
E
R
G
D
L
-
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
-
I
V
V
-
G
S
P
N
------------
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
G
I
T
A
K
E
L
D
S
I
A
R
N
I
I
A
E
Y
----
G
Y
-------
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
R
-
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
-
I
G
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
---------------------------------------------------------------------
55
HHSearch
80.98
22%
-66
- C1 -
3IG4
4
?
A:
[42-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
N
R
-----
N
F
Y
Y
V
T
G
I
D
E
-
P
N
------
V
--
I
F
M
L
K
K
F
GN
S
V
E
E
T
L
F
I
E
K
S
D
P
V
M
E
K
W
V
G
K
T
V
S
N
E
E
A
E
K
I
S
G
I
K
K
V
I
Y
L
D
S
F
-------
E
K
T
M
S
N
I
----
F
----
F
TENV
K
H
L
Y
L
D
LECREWKG
T
-
E
T
K
T
L
A
F
A
K
H
V
R
E
Q
Y
P
----
H
V
T
I
G
N
-
V
Y
P
N
I
--
C
E
L
R
V
F
K
T
D
E
E
I
E
I
I
K
E
A
I
A
V
T
K
D
G
I
Y
N
V
L
K
H
A
K
A
------
D
M
M
E
Y
E
L
E
A
Q
F
D
F
T
L
K
S
-
S
-
G
I
K
H
H
A
F
N
T
I
L
A
S
G
K
N
A
T
V
L
H
Y
E
D
N
D
A
---
Q
I
Q
N
G
D
L
V
L
L
D
L
G
A
Q
K
D
Y
Y
N
A
D
I
S
Y
T
-
F
P
A
N
G
T
-----------
F
S
S
R
Q
K
Q
-
I
Y
N
I
V
L
N
A
L
K
E
T
T
E
I
I
K
P
G
L
K
F
A
A
L
N
E
H
A
K
K
V
L
A
E
G
C
K
A
V
G
L
IQEDEE
L
S
K
Y
Y
Y
H
G
V
S
H
F
L
G
--
L
D
T
H
D
V
G
T
----
Y
--
K
D
R
V
L
E
E
G
M
V
I
T
I
E
P
G
L
Y
I
E
E
E
S
I
G
I
R
I
E
D
D
I
L
V
T
K
D
G
H
E
N
L
---------------------------------------------------------------------
27
PsiBlast_CBE
80.69
36%
-70
- C1 -
1WY2
3
PEPQ_PYRHO
B:
[108-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
N
I
K
E
F
K
K
V
D
D
V
I
-------------------
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
------
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
-
G
A
E
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
S
D
K
R
--
I
E
R
G
D
L
-
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
-
I
V
V
-
G
S
P
N
------------
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
K
K
A
V
E
S
A
K
P
G
I
T
A
K
E
L
D
S
I
A
R
N
I
I
A
E
Y
----
G
Y
-------
G
E
Y
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
R
-
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
P
K
-
I
G
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
---------------------------------------------------------------------
3
PsiBlast_PDB
79.96
42%
-57
- C1 -
4RGZ
2
?
A:
[138-354]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
------
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
-
E
F
G
A
D
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
S
H
R
K
--
I
R
K
G
D
-
V
V
I
F
D
Y
G
A
K
Y
L
G
Y
C
S
D
V
T
R
T
-
V
V
V
-
G
P
P
S
-----------
E
E
V
K
K
-
V
Y
E
I
V
K
E
A
Q
E
T
A
V
Q
K
V
A
E
G
I
P
A
E
V
V
D
A
T
A
R
G
I
I
S
K
Y
----
G
Y
-------
G
E
Y
F
I
H
R
T
G
H
G
L
G
--
I
D
V
H
E
E
P
Y
-
I
S
P
G
--
N
K
K
I
L
K
D
G
M
V
F
T
I
E
P
G
I
Y
L
Q
G
-
K
F
G
V
R
I
E
D
D
V
A
L
V
D
K
K
G
I
R
L
---------------------------------------------------------------------
72
Fugue
79.44
22%
-63
- C1 -
3CTZ
5
XPP1_HUMAN
A:
[3-619]
PKVT
S
E
L
L
R
Q
L
R
Q
A
M
R
NSEYVTEPIQ
A
Y
I
I
P
SGDAHQSEYIAPCDC
R
R
A
F
V
S
GFDGS
A
G
T
A
I
I
T
EE
H
A
A
M
W
T
D
GRY
F
L
Q
A
A
K
Q
M
DSN
W
T
L
M
K
M
GLKDTPT
Q
E
D
W
L
V
S
V
LPEG
S
R
V
G
V
DPLIIP
T
D
Y
W
K
K
M
A
K
V
L
R
S
A
G
H
H
L
I
P
V
KEN
L
V
D
K
I
WTDRPER
P
C
K
P
L
L
T
L
G
LDYTGIS
W
K
D
K
V
A
D
L
R
L
K
M
A
E
R
NVM
W
F
V
V
TA
L
D
E
I
A
W
L
F
N
L
R
G
S
D
------
V
E
H
N
-----
P
V
F
F
S
Y
A
I
I
G
-
L
E
------
T
--
I
M
L
F
I
D
----
G
D
R
I
D
--
A
P
S
V
K
E
-
H
L
L
L
D
L
G
L
-
E
-------
A
E
-
Y
R
I
Q
V
H
P
Y
K
S
I
L
S
E
L
K
A
L
C
A
D
L
----
S
----
P
----
R
E
K
V
W
V
--------
S
-
D
K
A
S
----
Y
A
V
S
E
T
I
P
----
K
D
H
R
C
C
M
P
Y
T
P
I
--
C
I
A
K
A
V
K
N
S
A
E
S
E
G
M
R
R
A
H
I
K
D
A
V
A
L
C
E
L
F
N
W
L
E
K
E
V
P
K
-
G
G
V
T
E
I
S
A
A
D
K
A
E
E
F
R
R
Q
Q
A
-
D
F
V
D
L
S
F
P
T
I
S
S
T
G
P
T
G
A
I
I
H
Y
A
P
V
P
E
T
N
R
T
L
S
L
D
E
V
Y
L
I
D
S
G
A
Q
Y
K
D
G
T
T
D
V
T
R
T
-
M
H
F
-
E
----------
T
P
T
A
Y
E
K
E
C
-
F
T
Y
V
L
K
G
H
I
A
V
S
A
A
V
F
P
T
G
T
K
G
H
L
L
D
S
F
A
R
S
A
L
W
D
S
----
G
L
-------
D
--
Y
L
H
G
T
G
H
G
V
G
SF
L
N
V
H
E
G
P
C
G
I
S
Y
K
TF
S
D
E
P
L
E
A
G
M
I
V
T
D
E
P
G
Y
Y
E
D
G
-
A
F
G
I
R
I
E
N
V
V
L
V
V
P
V
K
T
K
Y
N
FNNR
G
S
L
T
L
E
P
L
T
L
V
P
I
QTKMIDVDSLT
D
K
E
C
D
W
L
N
N
Y
H
L
T
C
R
D
V
I
G
K
E
L
Q
K
Q
GR
Q
E
A
L
E
W
L
I
R
E
T
QPI