@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0461: (2015-12-15 )
MVVRTQNSESKIKEFFEFCKENEVEFVDFRFSDIKGTWNHIAYSFGALTHDMFKEGIPFDASSFKGWQGIEHSDMILTPDLVRYFIDPFSADVSAVVFCDVYDVYKNQPYEKCPRSIAKKALKHLRDLGLGDVAYFGAENEFFIFDSIKIKDASNSQYYEVDSEEGEWNRDKSFENGVNFGHRPGKQGGYMPVPPTDTMMDIRTEIVKVLNQVGLETFVVHHEVAQAQGEVGVKFGDLVEAADNVQKLKYVVKMVAHLNGKTATFMPKPLYGDNGSGMHTHVSIWKNNENLFGGETYKGLSEFALYFLGGVLRHARGLAAFTNASTNSYKRLIPGYEAPSILTYSASNRSASVRIPYGISKNSARFEFRFPDSSSNPYLAFGAILMAGIDGIKNKMDPGEAMDINLFKLTLDEIREKGIKQMPHTLRRSLEEMLADKQYLKEGQVFSEEFIQAYQSLKFHSEVFPWESKPHPFEFITTYSC
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.-.......90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....-..230.......240.......250.......260.......270.......280.......290-.......300.......310.......320.......330.......340.......350....-...360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
V
RTQN
S
E
S
K
I
K
E
F
F
E
F
C
K
ENE
V
E
F
V
D
F
R
FSDIK
G
T
W
N
H
I
A
Y
S
F
G
A
L
T
H
D
M
F
KEGIPFDASSFKGWQGIEHSDMIL
T
P
D
L
V
-
R
Y
F
IDPFSAD
V
S
A
V
V
F
C
D
V
Y
D
V
YKNQ
P
Y
E
K
C
P
R
S
I
A
K
K
A
L
K
H
L
R
DLGLGD
V
A
Y
FGAEN
E
F
F
I
F
D
S
I
K
I
KDASNS
Q
Y
Y
E
VDSEEGEWNRDKSFENGVNFGHRPGKQGG
Y
M
PVPPT
D
T
M
M
D
I
R
T
E
I
V
K
V
L
N
QVG
L
E
T
F
V
V
H
H
E
V
A
Q
A-QGEVGV
K
F
G
D
L
V
E
A
A
D
N
V
Q
K
L
K
Y
V
V
K
M
V
A
HLNGKTATFMPKPLYGDNGSG
M
H
T
H
V
S
I
W
KNNENLF-G
G
E
T
Y
K
G
L
S
E
F
A
L
Y
F
L
G
G
V
L
R
HARGLAAFTNASTN
S
Y
K
R
LIPGYEA
P
S
I
L
T
Y
SASNR
S
A
S
V
R
I
P
-YGISKNS
A
R
F
E
F
RFPDSSSNP
Y
L
A
F
G
A
I
L
M
A
G
I
D
G
IKNKMDPGEA
M
D
I
N
L
F
K
L
T
L
D
E
I
R
E
K
G
I
K
Q
M
P
H
T
L
R
R
S
L
E
E
M
L
A
D
K
Q
Y
L
KEGQ
V
F
S
E
E
F
I
Q
A
Y
Q
SLKFHSEVFPWESKPH
P
F
E
F
I
T
TYSC
186
Fugue
90.56
49%
-74
- C3 -
1F52
2
GLNA_SALTY
A:
[1-468]
----------
S
A
E
H
V
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
T-
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
-
G
G
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
S
G
-
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
V
V
A
-
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
--
A
K
E
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
R
E
-
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
52
PsiBlast_CBE
90.55
49%
-75
- C3 -
1LGR
2
GLNA_SALTY
C:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
51
PsiBlast_CBE
90.54
49%
-75
- C3 -
1LGR
2
GLNA_SALTY
D:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
32
PsiBlast_CBE
90.44
49%
-75
- C3 -
2LGS
22
GLNA_SALTY
L:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
43
PsiBlast_CBE
90.42
49%
-75
- C3 -
1LGR
22
GLNA_SALTY
L:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
40
PsiBlast_CBE
90.41
49%
-75
- C3 -
2LGS
2
GLNA_SALTY
D:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
41
PsiBlast_CBE
90.39
49%
-75
- C3 -
2LGS
2
GLNA_SALTY
C:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
38
PsiBlast_CBE
90.36
49%
-76
- C3 -
2LGS
2
GLNA_SALTY
F:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
42
PsiBlast_CBE
90.32
49%
-76
- C3 -
2LGS
2
GLNA_SALTY
B:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
84
PsiBlast_CBE
90.31
49%
-71
- C3 -
1F1H
2
GLNA_SALTY
D:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
85
PsiBlast_CBE
90.25
49%
-71
- C3 -
1F1H
2
GLNA_SALTY
C:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
53
PsiBlast_CBE
90.25
49%
-75
- C3 -
1LGR
2
GLNA_SALTY
B:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
6
PsiBlast_PDB
90.14
49%
-76
- C3 -
2LGS
2
GLNA_SALTY
A:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
------
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
----
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
---------------
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
62
PsiBlast_CBE
90.13
49%
-70
- C3 -
1FPY
2
GLNA_SALTY
D:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
3
PsiBlast_PDB
90.12
49%
-71
- C3 -
1F1H
2
GLNA_SALTY
A:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
64
PsiBlast_CBE
90.11
49%
-70
- C3 -
1FPY
2
GLNA_SALTY
B:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
60
PsiBlast_CBE
90.11
49%
-70
- C3 -
1FPY
2
GLNA_SALTY
F:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
4
PsiBlast_PDB
90.08
49%
-70
- C3 -
1FPY
2
GLNA_SALTY
A:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
75
PsiBlast_CBE
90.07
49%
-70
- C3 -
1F52
43
GLNA_SALTY
B:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V
86
PsiBlast_CBE
90.06
49%
-71
- C3 -
1F1H
2
GLNA_SALTY
B:
[6-468]
---------------
L
T
M
L
N
E
H
E
V
K
F
V
D
L
R
F
T
D
T
K
G
K
E
Q
H
V
T
I
P
A
H
Q
V
N
A
E
F
F
E
E
G
K
M
F
D
G
S
S
I
G
G
W
K
G
I
N
E
S
D
M
V
L
M
P
D
A
S
-
T
A
V
I
D
P
F
F
A
D
S
T
L
I
I
R
C
D
I
L
E
P
G
T
L
Q
G
Y
D
R
D
P
R
S
I
A
K
R
A
E
D
Y
L
R
A
T
G
I
A
D
T
V
L
F
G
P
E
P
E
F
F
L
F
D
D
I
R
F
G
A
S
I
S
G
S
H
V
A
I
D
D
I
E
G
A
W
N
S
S
T
K
Y
E
G
G
-
N
K
G
H
R
P
G
V
K
G
G
Y
F
P
V
P
P
V
D
S
A
Q
D
I
R
S
E
M
C
L
V
M
E
Q
M
G
L
V
V
E
A
H
H
H
E
V
A
T
A
G
Q
N
E
V
A
T
R
F
N
T
M
T
K
K
A
D
E
I
Q
I
Y
K
Y
V
V
H
N
V
A
H
R
F
G
K
T
A
T
F
M
P
K
P
M
F
G
D
N
G
S
G
M
H
C
H
M
S
L
A
K
N
G
T
N
L
F
-
S
G
D
K
Y
A
G
L
S
E
Q
A
L
Y
Y
I
G
G
V
I
K
H
A
K
A
I
N
A
L
A
N
P
T
T
N
S
Y
K
R
L
V
P
G
Y
E
A
P
V
M
L
A
Y
S
A
R
N
R
S
A
S
I
R
I
P
-
V
V
A
S
P
K
A
R
R
I
E
V
R
F
P
D
P
A
A
N
P
Y
L
C
F
A
A
L
L
M
A
G
L
D
G
I
K
N
K
I
H
P
G
E
P
M
D
K
N
L
Y
D
L
P
P
E
E
A
K
E
--
I
P
Q
V
A
G
S
L
E
E
A
L
N
A
L
D
L
D
R
E
F
L
K
A
G
G
V
F
T
D
E
A
I
D
A
Y
I
A
L
R
-
R
E
E
D
D
R
V
R
M
T
P
H
P
V
E
F
E
L
Y
Y
S
V