@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0659: (2015-12-17 )
MKKTILLSLSLSLASSLLHAEDNGFFVSAGYQIGEAVQMVKNTGELKNLNDKYEQLSQSLAQLASLKKSIQTANNIQAVNNALSDLKSFASNNHTNKETSPIYNTAQAVITSVLAFWSLYAGNALSFHVTGLNDGSNSPLGRIHRDGNCTGLQQCFMSKETYDKMKTLAENLQKAQGNLCALSECSSNQSNGGKTSMTTALQTAQQLMDLIEQTKVSMVWKNIVIAGVTNKPNGAGAITSTGHVTDYAVFNNIKAMLPILQQALTLSQSNHTLSTQLQARAMGSQTNREFAKDIYALAQNQKQILSNASSIFNLFNSIPKDQLKYLENAYLKVPHLGKTPTNPYRQNVNLNKEINAVQDNVANYGNRLDSALSVAKDVYNLKSNQTEIVTTYNDAKNLSEEISKLPYNQVNVTNIVMSPKDSTAGQYQINPEQQSNLNQALAAMSNNPFKKVGMISSQNNNGALNGLGVQVGYKQFFGESKRWGLRYYGFFDYNHGYIKSSFFNSSSDIWTYGGGSDLLVNFINDSITRKNNKLSVGLFGGIQLAGTTWLNSQYMNLTAFNNPYSAKVNASNFQFLFNLGLRTNLATAKKKDSERSAQHGVELGIKIPTINTNYYSFLGTKLEYRRLYSVYLNYVFAY
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------.........10........20........30........40.........50..--------------......60....-----....70.....---...80........90.-.......100--..---.....110.......120----.......-130....---------...140----.......150.......160...------....170....-------.--..180.......-----190..-......200-----------.......210...----....220.......230.......240.......250.......260.....-..270.......-280......---.290----------.......300-........310...---....320...----------....--330.......340.......350....-----...360.....-..370.......380.......390.......400....--------...410-----.......420.......--.430.......440.......450.......460.......470.......480.......490.......500-.......510..--.....520.......530.......540.......550.......560......-.570.....-..580.......590.......600-........610..-..-...----620.....---..630......--------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------MK
K
T
I
L
L
S
L
S
L
S
L
A
S
S
L
LHAEDN
G
F
F
V
SAGYQ
I
G
E
A
V
Q
M
V
-
K
NTGELKN
L
N
D
K
Y
--------------
E
Q
L
S
Q
S
L
A
Q
L
A
S
-----
L
K
K
S
I
Q
TAN
N
I
---
Q
A
V
N
N
A
L
S
D
L
K
S
F
ASN-NHTNKETSP
I
--
Y
N
---
T
A
Q
A
V
I
T
S
V
L
A
F
W
S
L
YAG----
N
A
L
S
F
H
V
-
T
GLNDGS---------NSPLGR----IHRDGN
C
T
G
L
Q
Q
C
F
MS
K
E
T
Y
D
K
M
------
K
T
L
A
E
N
L
Q
K
AQ-------G--
N
L
C
A
L
SECSSNQ-----S-NGG-
K
T
S
M
T
T
A
L
Q
-----------
T
A
Q
Q
L
M
D
L
I
E
Q
T
K
----
V
S
M
V
W
K
N
I
V
I
A
GVTNKPNGA
G
A
ITSTGHV
T
D
Y
A
V
F
N
N
I
K
A
M
L
P
I
L
Q
Q
A
L
T
LS-QSNH
T
L
S
T
Q
L
Q
A
-
R
AMGSQ
T
N
R
---
E
F
A
K
----------
D
I
Y
A
L
A
Q
N
Q
--
K
Q
I
L
S
N
A
S
S
I
F
N
L
F
---
N
SI
P
K
D
Q
L
K
Y
----------
L
E
N
A
--
Y
LKVPHLGKTPTNPYRQNVNLNK
E
I
N
A
-----
V
Q
D
N
V
A
N
Y
G
N
R
-
L
D
S
A
L
S
V
A
K
D
V
Y
NLKSN
Q
T
E
I
V
T
TYN
D
A
K
N
L
S
E
E
I
S
KLP--------YNQV
N
V
-----
T
N
I
V
MSPK-DSTAG
Q
Y
Q
--I
N
P
E
Q
QS
N
L
N
Q
A
L
A
A
MSNNPF
K
K
VG
M
I
SSQNNNGALN
G
L
G
V
QV
G
Y
K
Q
FFGESKR
W
G
L
R
Y
Y
G
F
F
DYNH
G
Y
I
KSSF-FNSSS
D
I
W
T
YGG--
G
S
D
L
L
V
N
F
I
N
D
S
ITRKNN
K
L
S
V
G
L
FG
G
I
Q
L
A
G
T
T
WLNS
Q
Y
M
N
L
T
AFNNPY
S
A
K
V-NAS
N
F
Q
F
L
F
-NLGLRTNLATAKKKDS
E
R
S
AQHG
V
--
E
L
G
I
K
IPTINT
N
Y
-
Y
S
-
F
LG----T
K
L
E
Y
R
R
L
---
Y
S
V
Y
L
N
Y
V
FAY--------------------------------------
1
PsiBlast_PDB
93.83
66%
-79
- C2 -
4O5J
3
?
A:
[27-400]
------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
L
N
E
K
Y
--------------
E
Q
L
S
Q
Y
L
N
Q
V
A
S
-----
L
K
Q
S
I
Q
N
A
N
N
I
---
E
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
-
N
Y
N
S
T
T
Q
S
P
I
--
F
N
---
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
----
N
Y
F
T
F
F
V
--
G
K
K
V
-
D
S
G
Q
P
A
SVQG
N
P
P
F
K
T
----
I
I
E
--
N
C
S
G
I
E
N
C
A
M
D
Q
T
T
Y
D
K
M
------
K
K
L
A
E
D
L
Q
A
A
Q
TNSATKG
N
--
N
L
C
A
L
S
G
C
A
A
T
-------S
N
P
P
-
N
S
T
V
S
N
A
L
N
-----------
L
A
Q
Q
L
M
D
L
I
A
N
T
K
----
T
A
M
M
W
K
N
I
V
I
S
G
V
S
N
T
---
S
G
A
I
T
S
T
N
Y
P
T
Q
Y
A
V
F
N
N
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
-
Q
S
N
H
T
L
S
A
S
L
Q
A
-
Q
A
T
G
S
Q
T
N
P
---
K
F
A
K
----------
D
I
Y
T
F
A
Q
N
Q
--
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
F
---
N
S
I
P
A
E
Q
Y
K
Y
----------
L
E
K
A
--
Y
L
K
I
P
N
A
G
S
T
P
T
N
P
Y
R
Q
V
V
N
L
N
Q
E
V
Q
T
-----
I
K
N
N
V
S
Y
Y
G
N
R
-
V
D
A
A
L
S
V
A
R
D
V
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
P
--------
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
92.73
65%
-76
- C2 -
4O5J
3
?
A:
[27-400]
------------------------------------------------------------------------------------------------------------------------------------------
L
K
N
L
N
E
K
Y
--------------
E
Q
L
S
Q
Y
L
N
Q
V
A
S
-----
L
K
Q
S
I
Q
N
A
N
N
I
---
E
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
-
N
Y
N
S
T
T
Q
S
P
I
--
F
N
---
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
----
N
Y
F
T
F
F
V
G
K
K
V
D
S
G
Q
---------
P
A
S
V
Q
G
NPPF
K
T
I
I
E
N
C
S
G
I
E
N
C
A
M
D
Q
T
T
Y
D
K
M
------
K
K
L
A
E
D
L
Q
A
A
Q
TNSATKG
N
--
N
L
C
A
L
S
G
C
A
A
T
------
S
-
N
P
P
-
N
S
T
V
S
N
A
L
N
-----------
L
A
Q
Q
L
M
D
L
I
A
N
T
K
----
T
A
M
M
W
K
N
I
V
I
S
G
V
S
N
T
S
---
G
A
I
T
S
T
N
Y
P
T
Q
Y
A
V
F
N
N
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
-
Q
S
N
H
T
L
S
A
S
L
Q
A
-
Q
A
T
G
S
Q
T
N
P
---
K
F
A
K
----------
D
I
Y
T
F
A
Q
N
Q
--
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
F
---
N
S
I
P
A
E
Q
Y
K
Y
----------
L
E
K
A
--
Y
L
K
I
P
N
A
G
S
T
P
T
N
P
Y
R
Q
V
V
N
L
N
Q
E
V
Q
T
-----
I
K
N
N
V
S
Y
Y
G
N
R
-
V
D
A
A
L
S
V
A
R
D
V
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
P
--------
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
56.43
16%
-24
* C1 *
3UGM
-
PTHX1_XANOP
A:
[169-1048]
KPKVRELVAHIVALSQHPAALGTVAVTYQHIITALAT
H
E
D
I
V
G
V
G
KQWSG
A
R
A
L
E
A
L
L
T
D
A
G
E
L
RGPPLQLDT
G
Q
L
V
K
I
A
K
R
GG
V
T
A
M
E
A
V
H
A
S
R
N
A
L
T
P
L
N
L
T
P
A
Q
V
V
A
I
A
S
N
N
G
-----
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
M
Q
R
L
L
P
V
L
C
Q
A
HGLP
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
H
G
---
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
AHGL
T
P
D
Q
V
V
A
-
I
A
S
H
D
G
G
---------
K
Q
A
L
E
T
----
V
Q
R
L
L
P
V
L
C
-
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
SNGG
G
K
Q
A
L
E
T
V
Q
R
L
L
-------
P
--
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
-
N
G
G
-
K
Q
A
L
E
T
V
Q
R
LLPVLCQAHGL
T
P
D
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
T
H
G
L
T
P
A
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
L
E
T
V
Q
Q
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
-
K
Q
A
L
A
T
V
Q
R
---
L
L
P
V
LCQAHGLTPD
Q
V
V
A
I
A
S
N
G
GG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
SNGG
G
K
Q
A
L
E
T
V
--
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
Q
V
Q
V
V
A
I
A
S
N
I
G
G
----------
K
Q
A
L
E
T
-
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
AHG
L
T
P
D
Q
V
-----
V
A
I
A
S
N
G
G
-
G
K
Q
A
L
E
T
V
--
Q
R
L
L
P
G
L
T
Q
E
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
-
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
-
G
L
T
P
A
Q
V
V
A
I
A
S
NI
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
L
A
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
G
L
-
T
Q
D
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
I
G
G
K
-
Q
A
-
L
E
T
----
V
Q
R
L
L
P
V
L
CQD
H
G
L
T
L
D
Q
V
V
A
I
A
S
N
GGK
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
DHGLTPDQVVAIASNSG
23
Fugue
54.98
21%
31
- C2 -
4ZH0
-
?
A:
[18-518]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
--------------
E
S
L
N
N
L
L
N
R
Y
S
T
-----
L
N
T
L
I
K
L
S
A
D
P
---
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
-
L
I
G
D
K
A
N
S
P
A
--
Y
Q
---
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
----
V
T
----------------------------------
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
K
T
I
F
N
N
-----------
E
P
G
Y
R
S
T
-------
S
--
I
T
C
S
L
N
G
H
S
P
G
------
Y
-
Y
G
P
M
S
I
E
N
F
K
K
L
N
-----------
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
----
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
-
V
T
T
T
I
S
S
K
V
V
D
S
-
R
A
D
G
N
T
T
G
V
S
Y
T
E
I
T
N
----------
K
L
E
G
V
P
D
S
A
--
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
---
N
N
A
-------------------
C
P
--
Y
F
H
A
P
---
K
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
-----
I
Q
--------
K
M
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
N
------
P
--------
F
T
D
A
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
---
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
Q
G
S
A
P
G
T
V
T
T
------------
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
-
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
--
I
A
D
T
L
V
N
----------------------------
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
-
N
--------
A
V
S
K
K
N
N
P
Y
S
P
Q
G
------------
I
D
T
N
Y
-
Y
L
--------
N
Q
N
S
Y
N
Q
I
---
Q
T
I
N
Q
E
L
------------------------------------------
25
Fugue
44.32
15%
-16
- C2 -
4L6Y
-
PRC1_HUMAN
A:
[6-454]
--------------------------------------------------------------------------------------------------------
R
R
S
E
V
L
A
E
E
S
I
V
C
L
Q
K
A
L
N
H
L
R
E
I
W
E
L
I
-
G
I
P
--------------------------
E
D
Q
R
L
Q
R
T
E
V
-----
V
K
K
H
I
K
E
L
L
D
M
---
M
I
A
E
E
E
S
L
K
E
R
L
I
K
S
I
-
S
V
C
Q
K
E
L
N
T
L
--
C
S
---
E
-------------------------
L
H
V
-
E
P
F
Q
E
E
G
---------
E
T
T
I
L
Q
----
L
E
K
D
L
R
T
Q
V
E
L
M
R
K
Q
K
K
E
R
K
Q
E
L
------
K
L
L
Q
E
Q
D
Q
E
L
C
-------
E
--
I
L
C
M
P
H
Y
D
I
D
S
A
-----
S
-
V
P
S
-
L
E
E
L
N
Q
F
R
Q
-----------
H
V
T
T
L
R
E
T
K
A
S
R
R
----
E
E
F
V
S
I
K
R
Q
I
I
L
C
M
E
E
L
D
--------------------------------------
H
T
P
D
T
S
F
E
R
-
D
V
V
C
E
D
E
D
A
-------------------
F
C
L
S
L
E
N
--
I
A
T
L
Q
K
L
L
R
Q
L
E
M
Q
---
K
S
Q
N
E
A
V
C
E
G
----------
L
R
T
Q
--
I
R
E
L
W
D
R
L
Q
I
P
----------
E
E
E
R
E
A
-----
V
A
T
I
M
S
G
S
K
A
K
-
V
R
K
A
L
Q
L
E
V
D
R
L
E
E
L
K
M
Q
N
M
K
K
V
I
E
A
I
R
V
E
L
V
Q
Y
W
D
Q
C
F
--------
Y
S
Q
E
Q
R
-----
Q
A
F
A
P
F
C
A
-
E
Y
T
E
S
L
L
Q
--
L
H
D
A
E
I
V
R
L
K
N
Y
Y
E
V
-----------------------------
H
K
E
L
F
E
G
V
Q
K
W
E
E
T
W
R
L
F
L
E
F
E
R
K
A
S
D
P
N
-----------
R
R
G
--
G
N
L
L
K
E
E
K
Q
R
A
K
L
Q
K
M
L
P
K
L
E
E
E
L
K
A
R
I
E
L
W
E
Q
E
-------------
H
S
K
A
F
M
V
-
N
G
Q
K
F
M
E
Y
V
-
A
E
Q
W
E
M
H
R
L
E
K
E
R
A
K
Q
E
R
--------------------------------------------------------------------------------------------
30
Fugue
39.44
10%
-0
- C1 -
3CAX
-
?
A:
[119-473]
--------------------------------------------------------------------------------------------------------------------------
L
P
E
G
H
P
L
K
T
L
-
Y
Q
--
E
N
K
E
I
M
K
D
A
--------------
E
M
L
N
L
Y
A
K
T
L
A
T
-----
T
K
D
E
R
M
R
E
E
I
L
---
G
V
L
E
E
I
V
S
S
L
R
M
V
G
F
T
-
H
Y
N
R
E
E
M
L
-----------------
I
F
P
Y
I
E
R
R
G
L
----
T
V
I
A
T
V
L
-
W
T
K
H
D
E
I
---------
R
A
M
I
K
Q
----
L
A
E
L
L
R
----------
K
R
E
E
M
P
W
------
E
E
F
V
E
K
F
K
A
K
A
-------
G
--
E
V
A
F
A
L
S
D
M
V
F
R
-----
E
-
N
N
I
-
F
Y
P
T
L
K
A
L
L
-----------
S
E
G
E
W
K
A
I
K
M
Q
E
D
----
E
I
---
G
Y
Y
K
V
K
P
P
E
W
D
P
G
E
D
V
K
P
L
H
P
W
E
I
N
P
E
L
N
V
E
Q
L
L
T
L
P
K
E
V
Q
Q
A
L
R
G
Q
-
P
L
E
F
D
K
T
Q
L
K
R
E
-
E
D
I
D
L
G
T
G
Y
---
L
N
I
E
----------
E
L
K
A
I
F
E
A
L
--
P
V
D
V
T
F
I
D
K
D
D
R
V
R
---
F
F
S
P
G
E
R
I
F
T
----------
R
T
P
S
--
V
L
G
R
P
V
Q
L
C
H
P
P
K
S
V
Y
V
V
N
K
I
L
K
A
F
K
E
GRKK
E
A
T
F
W
L
R
L
R
E
K
Y
-
V
Y
I
K
Y
V
P
L
F
N
E
K
G
E
Y
I
G
T
L
E
M
T
M
D
I
A
P
Y
K
K
I
E
G
E
K
R
L
L
D
--------
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
37.70
14%
3
- C2 -
1R8I
-
?
A:
[32-218]
-------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
I
K
Q
G
--------------
E
Q
L
E
Q
M
A
Q
Q
L
E
Q
-----
L
K
S
Q
L
E
T
Q
K
N
M
---
Y
E
S
M
A
K
T
T
N
L
G
D
L
L
G
T
-
S
T
N
T
L
A
N
N
L
P
--
D
N
WKE
V
Y
S
D
A
M
N
S
S
S
S
V
T
P
S
V
N
S
----
M
M
G
Q
F
N
A
-
E
V
D
D
M
T
P
---------
S
E
A
I
A
Y
----
M
N
K
K
L
A
E
K
G
A
Y
D
R
V
M
A
E
K
A
Y
N
N
Q
------
M
Q
E
L
S
D
M
Q
A
L
T
-------
E
--
Q
I
------
K
S
T
P
-----
D
-
L
K
S
-
I
A
D
L
Q
A
R
I
Q
-----------
T
S
Q
G
A
I
Q
G
-
E
Q
A
K
----
L
N
L
M
N
M
L
Q
Q
S
Q
D
K
L
L
R
A
Q
K
D
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
33.76
35%
5
- C2 -
4ZH7
-
?
A:
[18-90]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
--------------
E
S
L
N
N
L
L
N
R
Y
S
T
-----
L
N
T
L
I
K
L
S
A
D
P
---
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
-
L
I
G
D
K
A
N
S
P
A
--
Y
Q
---
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
----
V
T
Q
C
G
G
N
-
A
N
G
Q
K
S
I
---------
S
S
K
T
I
F
----
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
------
G
P
M
S
I
E
N
F
K
K
L
-------
N
--
E
A
Y
Q
I
L
Q
T
A
L
K
R
-----
G
-
L
P
A
-
L
K
E
N
N
G
K
V
N
-----------
V
T
Y
T
Y
T
C
S
G
D
G
N
N
----
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
N
T
T
G
V
S
Y
T
E
-
I
T
N
K
L
E
G
V
P
D
S
A
-
Q
A
L
L
A
Q
A
S
T
---
L
I
N
T
----------
I
N
N
A
C
P
Y
F
H
--
A
F
S
T
T
T
G
K
I
C
G
A
F
S
---
E
E
I
S
A
I
Q
K
M
I
----------
T
D
A
Q
--
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
N
-----
P
F
T
D
A
S
F
A
Q
G
M
-
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
--------
T
C
N
N
P
S
-----
Q
G
S
A
P
G
T
V
-
T
T
Q
T
F
A
S
G
--
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
-
P
Y
S
P
Q
G
I
D
T
N
Y
Y
--
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
33.39
34%
5
- C2 -
4ZH0
-
?
A:
[18-90]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
--------------
E
S
L
N
N
L
L
N
R
Y
S
T
-----
L
N
T
L
I
K
L
S
A
D
P
---
S
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
-
L
I
G
D
K
A
N
S
P
A
--
Y
Q
---
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
Y
----
V
T
Q
C
G
G
N
-
A
N
G
Q
K
S
I
---------
S
S
K
T
I
F
----
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
------
G
P
M
S
I
E
N
F
K
K
L
-------
N
--
E
A
Y
Q
I
L
Q
T
A
L
K
R
-----
G
-
L
P
A
-
L
K
E
N
N
G
K
V
N
-----------
V
T
Y
T
Y
T
C
S
G
D
G
N
N
----
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
N
T
T
G
V
S
Y
T
E
-
I
T
N
K
L
E
G
V
P
D
S
A
-
Q
A
L
L
A
Q
A
S
T
---
L
I
N
T
----------
I
N
N
A
C
P
Y
F
H
--
A
P
K
F
S
T
T
T
G
K
I
C
G
A
---
F
S
E
E
I
S
A
I
Q
K
----------
M
I
T
D
--
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
-----
F
N
P
F
T
D
A
S
F
A
Q
-
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
--------
L
A
T
C
N
N
-----
P
S
Q
G
S
A
P
G
-
T
V
T
T
Q
T
F
A
--
S
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
-
N
N
P
Y
S
P
Q
G
I
D
T
N
--
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
33.24
18%
122
- C2 -
3MFN
-
?
A:
[113-152]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
------
V
S
V
Y
E
Q
L
H
L
V
M
-------
A
YD
G
------------------
V
G
D
-
A
E
V
V
K
L
G
F
Q
-----------
R
A
E
I
I
I
D
W
V
E
R
R
L
----
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
32.39
14%
23
- C3 -
1P4T
7
?
A:
[24-155]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
F
S
P
R
I
S
A
G
Y
R
--
I
N
--
D
-
L
R
F
A
--
V
--
D
Y
T
R
Y
K
N
Y
K
A
----
P
S
T
D
F
K
L
Y
S
I
--
G
A
S
A
I
Y
D
F
D
T
Q
S
--------
P
V
K
P
Y
L
G
A
R
L
S
L
N
R
A
S
V
D
L
G
G
---------
S
D
S
F
-
S
Q
T
S
I
G
L
G
V
-
L
T
G
V
S
Y
A
V
T
----------
P
N
V
D
L
--
D
A
G
Y
R
Y
N
Y
I
G
K
V
N
----
T
-------
V
K
N
-
V
R
S
---
G
E
L
S
A
G
V
R
V
K
F
--------------------------------------
10
HHSearch
32.31
11%
-19
- C3 -
2F1V
1
OMPW_ECOLI
A:
[35-191]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
Q
L
G
L
T
F
T
Y
--
M
A
T
--
D
N
I
G
V
E
L
L
A
A
T
P
F
-
R
H
K
I
G
T
R
A
-
T
G
D
I
A
T
V
H
H
L
P
P
--
T
L
M
A
Q
W
Y
F
G
D
A
S
-------
S
K
F
R
P
Y
V
G
A
G
I
N
Y
T
T
F
F
D
N
G
F
N
D
H
-
G
K
E
A
G
L
S
D
L
S
-
L
K
D
S
W
G
A
A
G
-
Q
V
G
V
D
Y
L
I
N
----------
R
D
W
L
V
--
N
M
S
V
W
Y
M
D
I
D
T
T
A
N
Y
K
-
L
G
G
AQQ
H
D
S
V
R
L
-
D
P
---
W
V
F
M
F
S
A
G
Y
R
F
--------------------------------------
11
HHSearch
31.70
16%
-5
- C3 -
2LHF
-
?
A:
[37-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
T
G
T
W
G
I
R
A
G
Q
Q
--
F
E
--
Q
---
G
R
Y
Y
A
T
Y
E
N
I
S
D
T
S
S
G
-----
N
K
L
R
Q
Q
N
L
L
G
--
S
Y
D
A
F
L
P
I
G
D
---------
N
N
T
K
L
F
G
G
A
T
L
G
L
V
K
L
E
Q
D
G
K
G
---------
F
K
R
D
-
S
D
V
G
Y
A
A
G
L
-
Q
A
G
I
L
Q
E
L
S
----------
K
N
A
S
I
--
E
G
G
Y
R
Y
L
R
T
N
A
S
T
-
E
M
T
P
H
G
G
N
KL
G
S
L
D
L
H
S
S
---
S
Q
F
Y
L
G
A
N
Y
K
F
--------------------------------------
14
HHSearch
31.69
16%
8
- C3 -
2X27
12
?
X:
[44-175]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
Q
L
G
L
T
F
T
Y
M
--
F
A
--
D
K
W
G
V
E
L
V
A
A
T
P
F
N
H
Q
V
D
V
K
G
L
L
D
G
K
L
A
D
I
K
Q
L
P
P
--
T
L
L
L
Q
Y
Y
P
M
G
G
T
------
N
S
A
F
Q
P
Y
G
G
L
G
V
N
Y
T
T
F
F
D
E
D
L
A
S
N
R
-
K
A
Q
G
F
S
S
M
K
-
L
Q
D
S
W
G
L
A
G
-
E
L
G
F
D
Y
M
L
N
----------
E
H
A
L
F
--
N
M
A
V
W
Y
M
D
I
D
T
K
A
-
S
I
-
N
G
P
----
S
A
L
G
V
N
K
T
---
K
V
D
V
D
V
D
P
W
V
Y
--------------------------------------
4
PsiBlast_PDB
31.28
28%
52
- C4 -
4Q6M
1
?
A:
[235-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
A
I
E
G
L
L
N
Q
L
N
I
---
P
F
K
R
----------
D
-
F
D
L
N
P
N
S
--
V
H
A
L
I
N
D
K
N
L
W
A
K
I
---
S
S
L
P
K
M
P
L
F
N
----------
L
R
P
K
LN
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-----
K
Q
E
V
F
L
K
Y
G
N
K
-
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
--------
E
S
F
Y
I
H
-----
A
M
D
N
I
R
A
N
-
V
I
G
F
S
V
S
N
--
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
31.05
28%
54
* C4 *
4Q6N
4
?
A:
[235-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
A
I
E
G
L
L
N
Q
L
N
I
---
P
F
K
R
----------
D
-
F
D
L
N
P
N
S
--
V
H
A
L
I
N
D
K
N
L
W
A
K
I
---
S
S
L
P
K
M
P
L
F
N
----------
L
R
P
K
LN
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-----
K
Q
E
V
F
L
K
Y
G
N
K
-
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
--------
E
S
F
Y
I
H
-----
A
M
D
N
I
R
A
N
-
V
I
G
F
S
V
S
N
--
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
30.90
14%
-2
* C3 *
3QRA
5
?
A:
[26-141]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
R
G
F
N
L
K
Y
R
Y
E
--
F
N
--
N
D
W
G
V
I
G
S
F
A
Q
T
R
R
G
F
E
E
S
V
----
L
I
D
G
D
F
K
Y
Y
S
V
--
T
A
G
P
V
F
R
I
N
--
E
--------
Y
V
S
L
Y
G
L
L
G
A
G
H
G
K
A
K
F
S
S
-
F
---------
G
Q
S
E
-
S
R
S
K
T
S
L
A
Y
-
G
A
G
L
Q
F
N
P
H
----------
P
N
F
V
I
--
D
A
S
Y
E
Y
S
K
L
D
D
V
K
-
V
G
-
T
W
M
----
L
G
A
G
Y
R
F
-----------------------------------------------------
8
PsiBlast_PDB
30.86
28%
50
- C4 -
4Q6Q
-
?
A:
[235-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
A
I
E
G
L
L
N
Q
L
N
I
---
P
F
K
R
----------
D
-
F
D
L
N
P
N
S
--
V
H
A
L
I
N
D
K
N
L
W
A
K
I
---
S
S
L
P
K
M
P
L
F
N
----------
L
R
P
K
LN
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-----
K
Q
E
V
F
L
K
Y
G
N
K
-
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
--------
E
S
F
Y
I
H
-----
A
M
D
N
I
R
A
N
-
V
I
G
F
S
V
S
N
--
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.41
28%
55
- C4 -
4Q6O
4
?
A:
[235-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
A
I
E
G
L
L
N
Q
L
N
I
---
P
F
K
R
----------
D
-
F
D
L
N
P
N
S
--
V
H
A
L
I
N
D
K
N
L
W
A
K
I
---
S
S
L
P
K
M
P
L
F
N
----------
L
R
P
K
LN
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-----
K
Q
E
V
F
L
K
Y
G
N
K
-
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
--------
E
S
F
Y
I
H
-----
A
M
D
N
I
R
A
N
-
V
I
G
F
S
V
S
N
--
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
29.36
28%
62
- C4 -
4Q6P
3
?
A:
[235-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
A
I
E
G
L
L
N
Q
L
N
I
---
P
F
K
R
----------
D
-
F
D
L
N
P
N
S
--
V
H
A
L
I
N
D
K
N
L
W
A
K
I
---
S
S
L
P
K
M
P
L
F
N
----------
L
R
P
K
LN
H
F
P
L
P
H
N
T
K
I
P
Q
I
P
I
E
S
N
A
Y
I
V
G
L
V
K
N
-----
K
Q
E
V
F
L
K
Y
G
N
K
-
L
M
T
R
L
S
P
F
Y
I
E
F
D
P
S
L
E
E
V
K
M
Q
I
D
N
K
D
Q
M
V
K
I
G
S
V
V
E
V
K
--------
E
S
F
Y
I
H
-----
A
M
D
N
I
R
A
N
-
V
I
G
F
S
V
S
N
--
E
N
K
P
N
E
A
G
Y
T
I
K
F
K
D
F
Q
K
R
F
S
L
D
K
Q
E
R
I
Y
R
I
E
F
Y
K
N
N
A
F
S
G
M
I
L
V
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------