@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0662: (2015-12-17 )
MKKTILLSLSLSLASSLLHAEDNGFFVSAGYQIGEAVQMVKNTGELKNLNEKYEQLSQYLNQVASLKQSIQNANNIELVNSSLNYLKSFTNNNYNSTTQSPIFNAVQAVITSVLGFWSLYAGNYLTFFVVNKDTQKPASVQGNPPFSTIVQNCSGIENCAMNQTTYDKMKKLAEDLQAAQQNATTKANNLCALSGCATTQGQNPSSTVSNALNLAQQLMDLIANTKTAMMWKNIVIAGVSNVSGAIDSTGYPTQYAVFNNIKAMIPILQQAVTLSQSNHTLSASLQAQATGSQTNPKFAKDIYAFAQNQKQVISYAQDIFNLFSSIPKDQYRYLEKAYLKIPNAGKTPTNPYRQEVNLNQEIQTIQNNVSYYGNRVDAALSVAKDVYNLKSNQTEIVTTYNNAKNLSQEISKLPYNQVNTKDIITLPYDQNAPAAGQYNYQINPEQQSNLSQALAAMSNNPFKKVGMISSQNNNGALNGLGVQVGYKQFFGESKRWGLRYYGFFDYNHGYIKSSFFNSSSDIWTYGGGSDLLVNFINDSITRKNNKLSVGLFGGIQLAGTTWLNSQYMNLTAFNNPYSAKVNASNFQFLFNLGLRTNLATAKKKDSERSAQHGVELGIKIPTINTNYYSFLGTKLEYRRLYSVYLNYVFAY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70......-..80........90........100------.......110.......120.......-130-....----..--.140.......150.......160.---..-.....170.......180.......190.......200.--......210.......220.......230--.........240.......250.......260--------........270.......280.......290.......300.......310.......320--....-...330.......340.......--350.......360....--....370...-....380-.......--390.....-..400.......410....----....420.-.......430........440.......450.......460.......470.......480.......490.......500.......510...-....520----........530.......540.......550.......560.......570.......580........590.......600.......610.......620.....-..-630----.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
T
I
L
L
S
L
S
L
S
L
A
S
S
L
LHAEDN
G
F
F
V
SAGYQ
I
G
E
A
V
Q
M
V
K
NTG
E
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
QNAN
N
I
E
-
L
V
N
S
S
L
N
Y
L
K
S
F
TNNNYNSTTQ
S
P
I
------
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
YAG
N
Y
L
T
F
F
V
-VNK-DTQK----PA--SVQGNP
P
F
S
T
I
V
Q
NCSG
I
E
NCA-MN---Q
T
-
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
QNATTKAN
N
L
C
A
LSGCATTQGQN--P
S
S
T
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
IANT
K
T
A
M
M
----
W
K
N
I
V
I
A
GVSNVSGAIDSTGYP
T
Q
Y
A
V
F
N
N
I
---------
K
A
M
I
P
I
L
Q
Q
A
V
TLSQSN
H
T
L
S
A
S
L
Q
A
QATGSQTN
P
K
F
A
K
D
I
Y
A
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
--
F
S
SI-
P
K
D
Q
Y
R
Y
L
E
K
A
Y
L
KIPNAGKTPT--NP
Y
R
Q
EVNL
N
Q
-
E
I
Q
T
I
--
Q
N
N
V
S
Y
YGN
R
-
V
D
A
A
L
S
V
-
A
K
D
V
Y
NL--KSN
Q
T
E
I
V
-
T
TYN
N
A
K
N
L
S
Q
E
I
-
S
KLPY----NQVNT-
K
D
-
I
I
T
LPYDQN-APAAG
Q
Y
N
Y
Q
IN
P
E
Q
Q
S
N
L
S
Q
A
L
A
A
MSNNPF
K
K
VG
M
I
SSQNNNGALN
G
L
G
V
QV
G
Y
K
Q
FFGESKR
W
G
L
R
Y
Y
G
F
F
DYNH
G
Y
I
KSSF-FNSSS
D
-----
I
W
T
YGG
G
S
D
L
L
V
N
F
I
N
D
S
ITRKNN
K
L
S
V
G
L
FG
G
I
Q
L
A
G
T
T
WLNS
Q
Y
M
N
L
T
AFNNPY
S
A
K
V-NAS
N
F
Q
F
L
F
NLGLRTNLATAKKKDS
E
R
S
AQHG
V
E
L
G
I
K
IPTINT
N
Y
-
Y
S
-
F
LG----T
K
L
E
Y
R
R
L
Y
S
V
Y
L
N
Y
V
FAY
1
PsiBlast_PDB
98.58
89%
-82
- C2 -
4O5J
3
?
A:
[27-400]
---------------------------------------------
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
-
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
------
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
N
Y
F
T
F
F
V
-
G
K
K
V
D
S
G
Q
----
P
A
--
S
V
Q
G
N
P
P
F
K
T
I
I
E
N
C
S
G
I
E
N
C
A
-
M
D
---
Q
T
-
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
N
S
A
T
K
G
N
N
L
C
A
L
S
G
C
A
A
T
---
S
NP
P
N
S
T
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
I
A
N
T
K
T
A
M
M
----
W
K
N
I
V
I
S
G
V
S
N
T
S
G
A
I
T
S
T
N
Y
P
T
Q
Y
A
V
F
N
N
I
---------
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
S
L
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
--
F
N
S
I
-
P
A
E
Q
Y
K
Y
L
E
K
A
Y
L
K
I
P
N
A
G
S
T
P
T
--
N
P
Y
R
Q
V
V
N
L
N
Q
-
E
V
Q
T
I
--
K
N
N
V
S
Y
Y
G
N
R
-
V
D
A
A
L
S
V
-
A
R
D
V
Y
N
L
--
K
S
N
Q
A
E
I
V
-
T
A
Y
N
D
A
K
T
L
S
E
E
I
-
S
K
L
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
97.67
89%
-82
- C2 -
4O5J
3
?
A:
[27-400]
---------------------------------------------
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
-
L
V
N
S
S
L
N
Y
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
------
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
A
G
N
Y
F
T
F
F
V
G
K
K
V
-
D
S
G
Q
----
P
A
--
S
V
Q
G
N
P
P
F
K
T
I
I
E
N
C
S
G
I
E
N
C
A
-
M
D
---
Q
T
-
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
N
S
A
T
K
G
N
N
L
C
A
L
S
G
C
A
A
T
S
N
P
---
P
N
S
T
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
I
A
N
T
K
T
A
M
M
----
W
K
N
I
V
I
S
G
V
S
N
T
S
G
A
I
T
S
T
N
Y
P
T
Q
Y
A
V
F
N
N
I
---------
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
S
L
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
--
F
N
S
I
-
P
A
E
Q
Y
K
Y
L
E
K
A
Y
L
K
I
P
N
A
G
S
T
P
T
--
N
P
Y
R
Q
V
V
N
L
N
Q
-
E
V
Q
T
I
--
K
N
N
V
S
Y
Y
G
N
R
-
V
D
A
A
L
S
V
-
A
R
D
V
Y
N
L
--
K
S
N
Q
A
E
I
V
-
T
A
Y
N
D
A
K
T
L
S
E
E
I
-
S
K
L
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
47.38
21%
24
- C2 -
4ZH0
-
?
A:
[18-518]
----------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
------
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
--
Y
V
T
Q
C
G
-
G
N
A
-
N
G
Q
K
SI
S
S
K
T
--
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
---
G
P
M
S
I
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
--
T
C
S
G
D
G
N
N
-
N
C
S
S
Q
V
T
----------------------
G
V
N
N
-----
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
---------
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
N
T
T
G
V
S
----------
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
--
I
N
N
A
C
P
----------
Y
F
H
A
P
---
K
F
S
T
--
T
T
G
K
I
C
G
A
F
S
E
-
E
I
S
A
I
--
Q
--------
K
M
I
T
D
A
Q
E
L
-
V
N
Q
T
S
V
I
--
N
E
H
E
Q
T
T
P
-
V
G
N
N
N
G
K
P
F
N
-------
P
F
----
T
D
A
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
M
L
N
L
A
E
Q
V
G
Q
A
I
N
P
E
R
---
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
Q
G
S
A
P
G
T
V
T
T
------------
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
-
G
T
Q
E
Q
Q
-----
I
Q
Q
A
E
N
I
A
D
T
L
V
N
----------------------------
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
--------
A
V
S
K
K
N
N
P
Y
S
P
Q
G
----------
I
D
T
N
Y
-
Y
L
--------
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
----
28
Fugue
42.15
9%
-26
- C2 -
2ODV
1
A:
[8-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
L
Q
L
R
W
Q
E
Y
R
E
L
V
L
L
L
L
Q
W
M
R
H
H
T
A
A
F
E
ERFP
S
S
F
E
E
I
E
I
L
W
S
Q
F
L
K
F
K
E
M
E
L
P
A
K
E
A
D
K
N
R
S
---------
K
G
I
Y
Q
S
L
E
G
A
V
Q
A
G
Q
L
K
V
P
P
G
Y
H
P
L
D
V
E
K
E
W
G
K
L
H
V
A
I
L
E
R
E
K
Q
L
R
S
E
F
E
R
L
E
A
L
Q
R
I
V
T
K
--
L
Q
M
E
-
A
G
L
A
E
E
Q
L
N
Q
A
D
A
L
L
Q
S
D
V
R
L
L
A
A
G
K
V
P
Q
R
A
G
E
V
E
R
-
D
L
D
K
A
--
D
S
M
I
R
L
L
F
N
D
-
V
Q
T
L
K
D
G
R
H
P
Q
G
E
Q
M
--
Y
R
R
V
Y
R
L
H
-
K
R
L
V
A
I
R
T
E
Y
N
L
R
-
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
40.10
13%
-8
- C1 -
4L6Y
-
PRC1_HUMAN
A:
[6-454]
------------
R
R
S
E
V
L
A
E
E
S
I
V
C
L
Q
K
A
L
N
H
L
R
E
I
W
E
L
I
G
I
P
--
E
D
Q
R
L
Q
R
T
E
V
V
K
K
H
I
K
E
L
L
D
M
M
I
A
-
E
E
E
S
L
K
E
-
R
L
I
K
S
I
S
V
C
Q
K
E
L
N
T
L
C
S
E
L
H
V
E
P
F
-----------------------------------------------------
Q
E
E
G
E
T
T
I
L
Q
L
E
K
D
L
R
T
Q
V
-
E
L
---
M
R
-
K
Q
K
K
E
R
K
Q
E
L
K
L
L
Q
E
Q
D
Q
E
L
C
E
I
L
C
M
--------
P
H
Y
D
I
--
D
S
A
S
V
P
S
L
E
E
L
N
Q
F
R
Q
H
V
T
T
L
R
E
T
K
A
S
----
R
R
E
E
F
V
S
I
K
R
Q
I
I
L
C
M
E
E
L
-------------------------------------
D
H
T
P
D
T
S
F
E
R
D
V
V
C
E
D
E
D
A
F
C
L
---------
S
L
E
N
I
A
T
L
Q
K
L
L
R
Q
--
L
E
M
Q
-
K
S
Q
N
E
A
V
C
E
G
L
R
T
Q
I
R
E
L
W
D
R
L
Q
--
I
P
-------
E
E
-
E
R
E
A
V
--
A
T
I
M
S
G
S
K
A
K
-
V
R
K
A
L
Q
L
-
E
V
D
R
L
E
E
--
L
K
M
Q
N
M
K
K
-
V
I
E
A
I
R
V
E
L
V
Q
Y
W
-
D
Q
C
F
Y
----
S
Q
E
Q
R
-
Q
---------
A
F
-
A
P
F
C
A
E
Y
T
E
S
L
L
Q
L
H
D
A
E
I
V
R
L
K
N
Y
Y
E
V
H
--------------------------
K
E
L
F
E
G
V
Q
K
W
E
E
T
W
R
L
F
L
E
F
E
R
K
A
S
D
P
N
----------------
R
R
G
G
N
L
L
K
E
E
K
Q
R
A
K
L
Q
K
M
L
P
K
L
E
E
E
L
K
A
R
I
E
L
W
E
Q
E
-------------
H
S
K
A
F
M
V
-
N
G
Q
K
F
M
E
Y
V
A
E
Q
W
E
M
H
R
L
E
K
E
R
A
K
Q
E
R
-------------------------------------------------
27
Fugue
39.82
14%
-5
- C2 -
1R8I
-
?
A:
[32-218]
------------------------------------
T
E
L
I
K
Q
G
E
Q
L
E
Q
M
A
Q
Q
L
E
Q
L
K
S
Q
L
E
T
Q
K
N
M
Y
E
S
M
A
K
T
T
N
L
G
D
L
L
G
T
S
T
N
T
L
A
N
N
L
P
D
N
W
K
E
V
Y
S
D
A
M
N
SSSSV
T
P
S
V
N
S
M
M
G
Q
F
N
A
E
V
D
D
M
T
P
S
E
A
I
A
Y
M
-
N
K
K
-
L
A
E
K
----
G
A
YD
R
V
M
A
E
K
A
Y
N
N
Q
M
Q
E
L
S
D
M
Q
A
L
T
-
E
Q
I
K
S
T
P
-
D
L
K
S
I
A
D
L
Q
A
R
I
Q
T
S
Q
G
A
I
Q
G
E
Q
A
K
L
N
L
M
N
M
L
Q
Q
S
Q
D
K
L
--
L
R
A
Q
K
D
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.47
36%
80
- C3 -
4NUR
-
?
A:
[341-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
-
Q
R
D
M
Y
R
Y
I
N
D
E
T
L
R
L
A
N
K
G
Y
T
M
T
--
E
-
I
A
E
Q
V
K
L
P
K
-
K
I
A
T
K
--
F
S
N
R
G
Y
Y
G
S
L
-
N
H
N
V
K
A
T
-
Y
V
L
Y
L
G
W
--
F
I
G
N
P
A
T
L
-
W
E
L
P
P
A
D
K
A
K
R
Y
V
-
E
M
M
G
G
----
A
D
A
V
L
-
K
K
-
A
K
E
Y
Y
D
K
G
D
-
F
R
W
V
A
E
V
V
N
H
V
V
F
A
E
P
N
N
Q
A
A
K
N
M
Q
A
D
A
L
E
Q
L
G
Y
Q
A
E
S
G
P
W
R
N
F
Y
L
T
G
A
Q
E
L
R
N
G
V
Q
Q
L
P
T
P
D
T
A
S
P
D
T
V
K
A
M
D
L
D
L
F
F
D
F
L
A
M
-
R
L
K
G
P
D
-----
V
A
D
K
H
I
T
L
N
L
D
F
T
D
L
K
Q
K
Y
T
L
E
M
V
N
G
V
L
N
H
T
E
G
M
Q
A
K
N
A
D
A
T
V
T
L
T
R
E
T
L
N
N
V
M
L
K
Q
T
T
L
-
K
D
A
E
S
S
G
D
I
K
I
E
G
D
K
G
K
L
E
E
L
M
S
Y
M
D
N
F
D
F
W
F
N
I
V
T
P
---------------------------------------
13
PsiBlast_PDB
36.73
26%
8
- C3 -
3PVZ
6
?
A:
[15-118]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
E
L
F
H
Q
D
I
N
A
N
E
K
E
L
Q
S
V
V
S
Q
S
R
F
L
V
L
G
G
A
-
G
S
I
G
Q
A
V
-
T
K
E
I
F
K
R
--
N
P
Q
K
L
H
V
V
D
I
S
E
N
N
M
V
E
L
V
R
D
I
R
S
S
F
G
Y
IN
G
D
F
Q
T
F
A
-
L
D
-
I
G
S
I
E
Y
D
A
F
-
I
K
A
D
G
Q
Y
D
Y
V
L
N
L
S
A
L
K
H
V
R
S
E
K
D
P
F
T
L
M
R
M
I
D
V
N
V
F
N
T
D
K
T
I
Q
Q
S
I
D
A
G
A
K
K
Y
F
C
V
S
T
D
K
A
A
N
P
V
N
M
M
G
A
S
K
R
I
M
E
M
F
L
M
R
K
S
-
E
E
I
A
I
S
-----
T
A
R
F
A
N
V
A
F
S
D
G
S
L
L
H
G
F
N
Q
R
I
Q
K
N
Q
P
I
V
A
P
N
D
I
K
R
Y
F
V
T
P
Q
E
S
G
E
L
C
L
M
S
C
I
F
G
E
N
R
D
I
-
F
F
P
K
L
S
E
A
L
H
L
I
S
F
A
D
I
A
V
K
Y
L
K
Q
L
G
Y
E
P
H
L
C
E
S
E
D
E
A
R
E
L
A
K
T
L
P
-
A
Q
-
G
K
W
----
P
C
L
F
T
S
S
E
F
F
T
D
K
E
T
L
D
M
A
2
PsiBlast_PDB
35.00
33%
-9
- C3 -
4ZH7
-
?
A:
[18-108]
----------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
------
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
--
Y
V
T
Q
C
G
-
G
N
A
-
N
G
Q
K
----
S
I
--
S
S
K
T
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
-
G
H
---
S
P
-
G
Y
Y
G
P
M
S
I
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
--
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
----
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
N
---------
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
--
I
Q
K
M
-
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
--
G
N
N
N
G
K
P
F
N
P
F
-
T
D
A
S
F
--
A
Q
G
M
L
A
N
A
S
A
-
Q
A
K
M
L
N
L
-
A
E
Q
V
G
Q
A
--
I
N
P
E
R
L
S
G
-
T
F
Q
N
F
V
K
G
F
L
A
T
C
-
N
N
P
S
Q
----
G
S
A
P
G
-
T
V
-
T
T
Q
T
F
A
S
G
C
-
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
-
Y
L
N
Q
N
S
-----
Y
N
Q
I
Q
T
I
N
Q
E
L
K
-----------------------------------------------------------------------------------------------------------------------------
30
Fugue
34.87
13%
-9
- C2 -
4CGK
7
?
A:
[42-392]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
T
A
Q
Q
Q
----
E
A
Q
K
Q
V
D
Q
I
Q
E
Q
V
S
A
I
Q
A
E
Q
S
N
L
Q
A
E
N
D
R
L
Q
---------
A
E
S
K
K
L
E
G
E
I
T
E
L
S
K
N
I
V
S
R
N
Q
S
L
E
K
Q
A
R
S
A
Q
T
N
G
A
V
T
S
Y
I
N
T
I
V
N
S
K
----
S
I
T
E
A
I
-------
S
R
-
V
A
A
M
S
E
I
V
S
A
N
N
K
M
L
E
Q
Q
K
A
D
K
K
--
A
I
S
E
K
Q
V
A
N
N
D
-
A
I
N
T
V
--
I
A
N
Q
Q
K
L
A
D
D
-
A
Q
A
L
T
T
K
-
Q
A
E
L
K
A
A
--
E
L
S
L
A
A
E
K
-
A
T
A
E
G
E
K
A
S
L
L
E
Q
-
K
A
A
A
E
----
A
E
A
R
A
-
A
A
-
V
A
E
A
A
Y
K
E
K
-
R
A
S
Q
Q
Q
S
V
L
A
S
A
N
T
N
L
T
A
Q
V
Q
A
V
S
E
S
A
A
A
P
V
R
A
K
V
R
P
T
Y
S
T
N
A
S
S
Y
P
I
G
E
C
T
W
G
V
K
T
L
A
----
P
W
A
G
D
Y
W
G
N
G
A
Q
W
A
T
S
A
A
A
A
G
-
F
R
T
G
S
T
PQVG
A
I
A
C
W
N
D
G
G
Y
G
H
V
A
V
V
T
A
V
E
S
T
T
R
I
Q
V
S
E
S
N
Y
A
G
N
R
T
I
G
N
---
H
R
G
W
F
N
P
T
T
T
S
E
G
F
V
T
Y
I
-
Y
A
D
-------------------------------------------------------------------------
3
PsiBlast_PDB
34.62
32%
-9
- C3 -
4ZH0
-
?
A:
[18-108]
----------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
N
A
V
R
E
N
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
------
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
V
G
--
Y
V
T
Q
C
G
-
G
N
A
-
N
G
Q
K
----
S
I
--
S
S
K
T
I
F
N
N
E
P
G
Y
R
S
T
S
I
T
C
S
L
N
-
G
H
---
S
P
-
G
Y
Y
G
P
M
S
I
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
--
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
----
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
S
R
A
D
G
N
---------
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
P
K
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
--
S
A
I
Q
-
K
M
I
T
D
A
Q
E
L
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
--
P
V
G
N
N
N
G
K
P
F
N
-
P
F
T
D
A
--
S
F
A
Q
G
M
L
A
N
A
-
S
A
Q
A
K
M
L
-
N
L
A
E
Q
V
G
--
Q
A
I
N
P
E
R
L
-
S
G
T
F
Q
N
F
V
K
G
F
L
A
-
T
C
N
N
P
----
S
Q
G
S
A
-
P
G
-
T
V
T
T
Q
T
F
A
S
-
G
C
A
Y
V
G
Q
T
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
Q
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
-
N
Y
Y
L
N
Q
-----
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
----------------------------------------------------------------------------------------------------------------------------
19
HHSearch
34.34
13%
26
- C4 -
1P4T
7
?
A:
[24-155]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
F
S
P
R
I
S
A
G
Y
R
--
I
N
--
D
-
L
R
F
A
--
V
--
D
Y
T
R
Y
K
N
Y
K
A
----
P
S
T
D
-----
F
K
L
Y
S
I
G
A
S
A
I
Y
D
F
D
T
Q
S
--------
P
V
K
P
Y
L
G
A
R
L
S
L
N
R
A
S
V
D
L
G
G
S
---------
D
S
F
-
S
Q
T
S
I
G
L
G
V
L
T
G
V
S
Y
A
V
T
----------
P
N
V
D
L
D
A
G
Y
R
Y
N
Y
I
G
K
V
N
----
T
-------
V
K
N
-
V
R
S
G
E
L
S
A
G
V
R
V
K
F
17
HHSearch
33.67
11%
-17
- C4 -
2F1V
1
OMPW_ECOLI
A:
[35-191]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
Q
L
G
L
T
F
T
Y
--
M
A
T
--
D
N
I
G
V
E
L
L
A
A
T
P
F
-
R
H
K
I
G
T
R
A
-
T
G
D
I
A
T
-----
V
H
H
L
P
P
T
L
M
A
Q
W
Y
F
G
D
A
S
-------
S
K
F
R
P
Y
V
G
A
G
I
N
Y
T
T
F
F
D
N
G
F
N
D
H
-
G
K
E
A
G
L
S
D
L
S
-
L
K
D
S
W
G
A
A
G
Q
V
G
V
D
Y
L
I
N
----------
R
D
W
L
V
N
M
S
V
W
Y
M
D
I
D
T
T
A
N
Y
K
-
L
G
G
AQQ
H
D
S
V
R
L
-
D
P
W
V
F
M
F
S
A
G
Y
R
F
22
HHSearch
33.09
14%
-0
* C4 *
3QRA
5
?
A:
[26-141]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
R
G
F
N
L
K
Y
R
Y
E
--
F
N
--
N
D
W
G
V
I
G
S
F
A
Q
T
R
R
G
F
E
E
S
V
----
L
I
D
G
D
-----
F
K
Y
Y
S
V
T
A
G
P
V
F
R
I
N
--
E
--------
Y
V
S
L
Y
G
L
L
G
A
G
H
G
K
A
K
F
S
S
-
F
---------
G
Q
S
E
-
S
R
S
K
T
S
L
A
Y
G
A
G
L
Q
F
N
P
H
----------
P
N
F
V
I
D
A
S
Y
E
Y
S
K
L
D
D
V
K
-
V
G
-
T
W
M
----
L
G
A
G
Y
R
F
------------
16
HHSearch
32.55
16%
-3
- C4 -
2LHF
-
?
A:
[36-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
N
T
G
T
W
G
I
R
A
G
Q
Q
--
F
E
--
Q
---
G
R
Y
Y
A
T
Y
E
N
I
S
D
T
S
S
G
-----
N
K
L
R
-----
Q
Q
N
L
L
G
S
Y
D
A
F
L
P
I
G
D
---------
N
N
T
K
L
F
G
G
A
T
L
G
L
V
K
L
E
Q
D
G
K
G
---------
F
K
R
D
-
S
D
V
G
Y
A
A
G
L
Q
A
G
I
L
Q
E
L
S
----------
K
N
A
S
I
E
G
G
Y
R
Y
L
R
T
N
A
S
T
-
E
M
T
P
H
G
G
N
KL
G
S
L
D
L
H
S
S
S
Q
F
Y
L
G
A
N
Y
K
F
26
Fugue
32.48
8%
9
- C2 -
2ZCO
-
CRTM_STAAU
A:
[1-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
M
M
D
M
N
F
K
Y
C
H
K
I
M
K
K
H
S
K
S
F
S
Y
A
F
D
L
L
P
E
D
Q
R
K
--
A
V
W
A
I
Y
A
V
C
R
K
I
D
D
S
I
D
V
Y
G
D
I
Q
F
L
N
Q
----
I
K
E
D
I
Q
S
I
E
K
Y
P
Y
E
Y
H
H
F
Q
S
D
R
R
I
M
M
A
L
Q
H
V
A
Q
H
K
NIA
F
Q
S
F
Y
N
L
I
D
T
V
Y
K
D
Q
H
F
T
M
F
E
T
D
A
E
L
F
G
Y
C
Y
G
V
A
G
T
V
G
E
V
L
T
P
I
L
S
D
H
E
T
H
Q
T
Y
D
V
A
R
R
L
G
E
S
L
Q
L
I
N
I
-
L
R
D
V
G
E
D
F
E
N
E
R
I
Y
F
S
K
Q
R
L
K
Q
Y
--
E
V
D
I
A
E
V
Y
Q
N
G
-
V
N
N
H
Y
--
I
D
L
W
E
Y
Y
A
A
I
-
A
E
K
D
F
R
D
-
V
M
D
Q
I
K
V
FS
I
E
A
Q
P
I
I
E
-
L
A
A
R
I
Y
I
E
I
L
D
E
V
-
R
Q
A
N
Y
----
T
-
L
H
E
-
R
V
-
F
V
E
K
R
K
K
A
K
-
L
F
H
E
I
N
S
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
31.64
25%
57
- C3 -
4AG5
2
?
A:
[334-386]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
E
K
--
D
L
E
A
I
T
T
L
M
N
L
S
E
A
E
H
D
L
L
V
N
A
K
R
G
-------
E
G
L
F
V
A
G
T
Q
R
I
H
I
K
I
E
A
A
P
Y
E
M
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
31.04
16%
10
- C4 -
2X27
12
?
X:
[44-175]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
Q
L
G
L
T
F
T
Y
M
--
F
A
--
D
K
W
G
V
E
L
V
A
A
T
P
F
N
H
Q
V
D
V
K
G
L
L
D
G
K
L
A
D
-----
I
K
Q
L
P
P
T
L
L
L
Q
Y
Y
P
M
G
G
T
------
N
S
A
F
Q
P
Y
G
G
L
G
V
N
Y
T
T
F
F
D
E
D
L
A
S
N
R
K
-
A
Q
G
F
S
S
M
K
-
L
Q
D
S
W
G
L
A
G
E
L
G
F
D
Y
M
L
N
----------
E
H
A
L
F
N
M
A
V
W
Y
M
D
I
D
T
K
A
-
S
I
-
N
G
P
----
S
A
L
G
V
N
K
T
K
V
D
V
D
V
D
P
W
V
Y
8
PsiBlast_PDB
30.29
32%
73
- C3 -
1O94
1
DHTM_METME
A:
[389-434]
--------------------
K
D
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
-
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
E
S
Q
L
A
L
G
Q
K
P
M
------
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
R
W
N
T
D
G
T
N
-
C
L
T
-
H
D
P
I
----
P
G
--
A
D
A
S
L
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
-
K
R
---
V
V
-
I
L
N
A
D
T
Y
F
M
A
P
S
L
A
E
K
L
A
T
A
G
H
E
V
T
I
V
S
G
V
H
L
A
N
Y
M
H
F
T
--
L
E
Y
P
N
M
M
R
R
L
H
E
L
H
V
E
E
L
G
D
H
F
C
S
R
I
E
----
P
G
R
M
E
I
Y
N
I
W
G
D
G
S
K
R
T
Y
R
G
P
G
V
S
P
R
D
A
N
T
S
---------
H
R
W
I
E
F
D
S
L
V
L
V
T
G
R
H
S
E
C
T
L
W
N
E
L
K
A
R
E
S
E
W
A
E
N
D
I
K
G
I
Y
L
I
G
D
A
E
A
P
R
L
I
A
D
A
T
F
T
G
H
R
--
V
A
R
E
-
I
E
E
A
N
P
Q
I
A
I
P
Y
K
R
E
T
I
A
W
G
T
P
H
--
M
P
G
G
N
F
K
I
E
Y
K
-
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
29.98
32%
78
- C3 -
1DJN
1
DHTM_METME
A:
[389-434]
--------------------
K
D
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
-
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
E
S
Q
L
A
L
G
Q
K
P
M
------
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
R
W
N
T
D
G
T
N
-
C
L
T
-
H
D
P
I
----
P
G
--
A
D
A
S
L
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
-
K
R
---
V
V
-
I
L
N
A
D
T
Y
F
M
A
P
S
L
A
E
K
L
A
T
A
G
H
E
V
T
I
V
S
G
V
H
L
A
N
Y
M
H
F
T
--
L
E
Y
P
N
M
M
R
R
L
H
E
L
H
V
E
E
L
G
D
H
F
C
S
R
I
E
----
P
G
R
M
E
I
Y
N
I
W
G
D
G
S
K
R
T
Y
R
G
P
G
V
S
P
R
D
A
N
T
S
---------
H
R
W
I
E
F
D
S
L
V
L
V
T
G
R
H
S
E
C
T
L
W
N
E
L
K
A
R
E
S
E
W
A
E
N
D
I
K
G
I
Y
L
I
G
D
A
E
A
P
R
L
I
A
D
A
T
F
T
G
H
R
--
V
A
R
E
-
I
E
E
A
N
P
Q
I
A
I
P
Y
K
R
E
T
I
A
W
G
T
P
H
--
M
P
G
G
N
F
K
I
E
Y
K
-
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------