@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0710: (2015-12-17 )
MVSTLKPLKIGKHTIKFPIFQGGMGVGISWDELAGNVAKEGALGVISAVGTGYYKNMRFVERIVAKKPFEALNFYSKKALNEIFANARKICGNKPLGANILYAINDYGRVLRDSCEAGANIIITGAGLPTNMPEFAKDFSDVALIPIISSAKALKILCKRWSDRYKRIPDAFIVEGPLSGGHQGFKYEDCFKEEFQLENLVPKVVEASKEWGNIPIIAAGGIWDKKDIDTMLSLGASGVQMATRFLGTKECDAKAYADLLPTLKKEDILLIKSPVGYPARAINTGVIKRIEEGNAPKIACVSNCVAPCNRGEEAKKVGYCIADGLGRSYLGNREEGLYFTGANGYRVDKIISVHELIKELTEG
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10......----..20........------30--.........40........50........60..--.....-----------.70-----.........80-.-.......90-.-..-......100---.----.----.-.-.----.----.---..110....-..--.120-.....--...--130------------------------------.----------------.......---.-140..-.--..-.----.-----150....------....160......----.170-.........-----------------------180..-..-.-..190.......200...--....210.......220.......230.-----------....-----------..240.......250---..-.-.-....260....-.-----------..270-------------.......280.......290-..----.....-300.......310.......320....-...330........340......-.350.........360.----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSTLKPLKIG
K
H
T
I
K
F
----
P
I
FQG
G
M
GVGI
S
------
W
---
D
E
L
A
G
N
V
A
KEGA
L
G
V
I
S
A
VGT
G
Y
Y
K
N
M
R
F
V
E
R
I
--
V
AKK
P
-----------
F
E
------
A
L
N
F
Y
S
K
K
A
L
N
-
E
-
I
F
A
N
A
R
K
I--C-GN-KPLG
A
N
I
-----
L
----
Y
----
A
-I-
N
----
D
----
Y
---
G
R
V
L
R
D
S
C
E-AG--
A
N
I
--
I
I
TGA--GLP--T--------------------------------N----------------
M
P
E
F
A
K
D
---F-SD
V
A
L
-
I
--
P
I-I----S-----S
A
-
K
A
L
K
------
I
L
C
K
R
W
S
D
R
Y
KRI----P
D
---
A
F
I
V
EGPLS-----------------------GGHQG-F
K
-
Y
-
E
D
C
F
K
E
E
F
Q
L
E
N
L
V
P
K
V
V
--
E
A
S
KEWGN
I
P
I
I
AAGGIWD
K
K
D
I
D
T
M
L
S
-----------LGAS-----------
G
V
Q
M
A
T
R
FLGTKEC----
D
A
-
K
-
A
-
Y
A
D
L
L
P
TLKKE-
D
-----------
I
L
L
I
K-------------SPVGYP
A
R
A
I
N
T
G
V
I
K
R
I
EE-GN----A
P
K
I
A
-
C
V
S
N
C
V
APCNR
G
E
E
A
K
K
V
G
Y
C
I
A
DGL
G
-
R
S
YL-GNREE
G
L
Y
F
TGANG
Y
R
V
D
-
K
I
--
I
S
V
H
E
L
I
K
E
LTEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
94.57
29%
-91
- C5 -
2Z6I
5
?
A:
[7-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
K
I
D
Y
----
P
I
F
Q
G
G
M
A
W
-
V
A
------
D
---
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
P
-------------------------------------------
K
E
V
V
K
-
A
-
N
I
D
K
I
K
S
L
----
T
D
-
K
P
F
G
V
N
I
-----
M
----
L
----
L
-
S
-
P
----
F
----
V
---
E
D
I
V
D
L
V
I
E
-
E
G
--
V
K
V
--
V
T
T
G
A
--
G
N
P
--
S
--------------------------------
K
----------------
Y
M
E
R
F
H
E
-----
A
G
I
I
V
-
I
--
P
V
-
V
----
P
-----
S
V
-
A
L
A
K
------
R
M
E
-------
K
I
G
----
A
D
---
A
V
I
A
E
G
M
E
A
-----------------------
G
G
H
I
G
-
K
L
-----------
T
T
M
T
L
V
R
Q
V
A
--
T
A
I
----
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
-----------
L
G
A
E
-----------
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
----
N
A
-
H
P
N
-
Y
K
E
K
I
L
K
A
R
D
I
-
D
-----------
T
T
I
S
A
-------------
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
----
D
A
F
K
Q
----
D
L
E
--
I
--------
F
E
Q
M
G
A
G
A
L
A
K
A
V
V
H
-
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
-
K
E
--
E
T
A
E
E
I
L
K
D
L
Y
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
92.54
28%
-86
* C5 *
3BO9
13
?
A:
[13-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
V
R
T
R
V
T
D
L
L
E
I
E
H
----
P
I
L
M
G
G
M
A
W
-
A
G
------
T
---
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
M
K
-------------------------------------------
P
D
D
L
R
-
K
-
A
I
S
E
L
R
Q
K
----
T
D
-
K
P
F
G
V
N
I
-----
I
----
L
----
V
-
S
-
P
----
W
----
A
---
D
D
L
V
K
V
C
I
E
-
E
K
--
V
P
V
--
V
T
F
G
A
--
G
N
P
--
T
--------------------------------
K
----------------
Y
I
R
E
L
K
E
-----
N
G
T
K
V
-
I
--
P
V
-
V
----
A
-----
S
D
-
S
L
A
R
------
M
V
E
-------
R
A
G
----
A
D
---
A
V
I
A
E
G
M
E
S
-----------------------
G
G
H
I
G
-
E
V
-----------
T
T
F
V
L
V
N
K
V
S
--
R
S
V
----
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
-----------
L
G
A
E
-----------
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
----
D
V
-
H
P
V
-
Y
K
E
K
I
V
K
A
S
I
R
-
D
-----------
T
V
V
T
G
-------------
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
----
E
N
P
M
Q
-
A
E
-
E
----------------
M
L
V
G
S
L
R
R
A
V
V
E
-
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
-
E
I
--
K
P
V
K
Q
I
I
E
D
I
L
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
90.17
24%
-79
- C5 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
T
R
F
T
E
T
F
G
---
V
E
H
----
P
I
M
Q
G
G
M
Q
-
W
V
G
------
R
---
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
------------------------------------------
L
T
Q
P
S
P
E
A
L
A
-
A
-
E
I
A
R
C
R
E
L
--
T
--
D
-
R
P
F
G
V
N
L
-----
T
L
L
PT
Q
----
K
-
P
-
V
----
P
----
Y
---
A
E
Y
R
A
A
I
I
E
-
A
G
--
I
R
V
--
V
E
T
A
G
--
N
D
P
--
G
--------------------------------
E
----------------
H
I
A
E
F
R
R
-----
H
G
V
K
V
-
I
--
H
K
-
C
----
T
-----
A
V
-
R
H
A
L
------
K
A
E
R
L
G
-----------
V
D
---
A
V
S
I
D
G
F
E
C
-----------------------
A
G
H
P
G
----------
E
D
D
I
P
G
L
V
L
L
P
A
A
A
--
N
R
L
----
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
-----------
L
G
A
D
-----------
A
I
N
M
G
T
R
F
L
A
T
R
E
C
----
P
I
H
P
-
A
-
V
K
A
A
I
R
A
A
D
E
R
-
S
-----------
T
D
L
I
M
-------------
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
-
I
E
----
A
R
G
G
A
-
G
Y
A
D
I
A
A
L
V
S
G
Q
R
G
R
Q
V
Y
Q
Q
-------------
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
-
D
E
--
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
RQR
L
E
G
M
L
A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
89.59
23%
-82
- C5 -
2GJL
1
2NPD_PSEAE
A:
[3-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
T
R
F
T
E
T
F
G
V
E
H
----
P
I
M
Q
G
G
M
Q
W
-
V
G
------
R
---
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
------------------------------------------
S
P
E
A
L
A
-
A
-
E
I
A
R
C
R
E
L
----
T
D
-
R
P
F
G
V
N
L
-----
T
----
L
----
L
-
P
-
T
QKPV
P
----
Y
---
A
E
Y
R
A
A
I
I
E
-
A
G
--
I
R
V
--
V
E
T
A
G
--
N
D
P
--
G
--------------------------------
E
----------------
H
I
A
E
F
R
R
-----
H
G
V
K
V
-
I
--
H
K
-
C
----
T
-----
A
V
-
R
H
A
L
------
K
A
E
-------
R
L
G
----
V
D
---
A
V
S
I
D
G
F
E
C
-----------------------
A
G
H
P
G
-
E
D
-
D
------
I
--
P
G
L
V
L
L
P
A
A
A
--
N
R
L
----
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
-----------
L
G
A
D
-----------
A
I
N
M
G
T
R
F
L
A
T
R
E
C
----
P
I
-
H
P
A
-
V
K
A
A
I
R
A
A
D
E
R
-
S
-----------
T
D
L
I
M
-------------
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
----
R
G
G
A
G
Y
A
D
I
A
A
L
V
S
G
--------
Q
R
G
-----
R
Q
-
V
Y
Q
Q
-
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
-
D
E
--
P
A
C
A
E
L
L
R
D
I
V
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.72
25%
-85
- C6 -
3BO9
13
?
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
H
----
P
I
L
M
G
G
M
----
A
------
W
AGT
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
---
G
S
G
--------------
A
M
K
P
-----------
D
D
------
L
-----
R
K
A
I
S
-
E
-
L
R
Q
K
T
--------
D
-
K
P
F
G
V
N
I
-----
I
----
L
----
V
-
S
-
P
----
W
----
A
---
D
D
L
V
K
V
C
I
E
-
E
K
--
V
P
V
--
V
T
F
G
A
--
G
N
P
--
T
--------------------------------
K
----------------
Y
I
R
E
L
K
E
-----
N
G
T
K
V
-
I
--
P
V
-
V
----
A
-----
S
D
-
S
L
A
R
------
M
V
E
R
A
G
A
D
--------------
A
V
I
A
E
G
M
E
S
-----------------------
G
G
H
I
G
-
E
V
-
T
-
T
------
F
V
L
V
N
K
V
S
R
S
V
---------
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
-----------
L
G
A
E
-----------
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
----
D
V
-
H
P
V
-
Y
K
E
K
I
V
K
A
S
I
R
-
D
-----------
T
V
V
T
G
-------------
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
-
M
E
----
F
-----------------
E
N
P
M
Q
A
E
E
M
L
V
G
S
L
R
-
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
-
E
I
--
K
P
V
K
Q
I
I
E
D
I
L
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.25
29%
-89
- C6 -
2Z6J
5
?
A:
[11-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
Y
----
P
I
F
Q
G
G
M
A
-
W
V
A
------
D
---
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
----------------
A
P
K
E
-----------
V
V
------
K
A
N
I
D
K
I
K
S
L
T
----------------
D
-
K
P
F
G
V
N
I
-----
M
----
L
----
L
-
S
-
P
----
F
----
V
---
E
D
I
V
D
L
V
I
E
-
E
G
--
V
K
V
--
V
T
T
G
A
--
G
N
P
--
S
--------------------------------
K
Y---------------
M
E
R
F
H
E
------
A
G
I
I
V
-
I
--
P
V
-
V
----
P
-----
S
V
-
A
----------
L
A
K
R
M
E
---
K
I
G
----
A
D
---
A
V
I
A
E
G
M
E
A
-----------------------
G
G
H
I
G
------------
K
L
T
T
M
T
L
V
R
Q
V
A
--
T
A
I
----
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
-----------
L
G
A
E
-----------
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
----
N
A
-
H
-
P
N
Y
K
E
K
I
L
K
A
R
D
I
-
D
-----------
T
T
I
S
A
-------------
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
-
A
E
----
K
D
A
F
E
-
Q
M
G
A
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
-
G
L
V
S
-
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
-
K
I
--
Q
E
E
A
S
R
W
T
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.43
30%
-102
- C6 -
2Z6I
5
?
A:
[53-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
I
D
K
I
K
S
L
-
T
D
-
K
P
F
G
V
N
I
-----
M
----
L
----
L
-
S
-
P
----
F
----
V
---
E
D
I
V
D
L
V
I
E
-
E
G
--
V
K
V
--
V
T
T
G
A
--
G
N
P
--
S
--------------------------------
K
----------------
Y
M
E
R
F
H
E
-----
A
G
I
I
V
-
I
--
P
V
-
V
----
P
-----
S
V
-
A
----------
L
A
K
R
M
E
---
K
I
G
----
A
D
---
A
V
I
A
E
G
M
E
A
-----------------------
G
G
H
I
G
------------
K
L
T
T
M
T
L
V
R
Q
V
A
--
T
A
I
----
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
-----------
L
G
A
E
-----------
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
----
N
A
-
H
-
P
N
Y
K
E
K
I
L
K
A
R
D
I
-
D
-----------
T
T
I
S
A
-------------
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
-
A
E
----
K
D
A
F
K
-
Q
D
L
E
I
F
E
Q
M
G
A
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
-
V
M
A
G
-
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
-
L
Y
--
Y
G
A
A
K
K
I
Q
E
E
A
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
69.65
21%
-88
- C5 -
1EEP
1
IMDH_BORBU
A:
[37-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
S
L
N
I
----
P
F
L
S
S
A
M
D
T
-
V
T
------
E
---
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
H
K
N
M
-
S
I
E
A
Q
R
K
E
I
E
K
V
--
K
T
Y
K
---------------------------------D
F
P
N
A
C
K
D
L
--
N
-
N
K
-
L
R
V
G
A
A
V
-----
S
----
I
------
D
-
I
----
D
----
T
---
I
E
R
V
E
E
L
V
K
-
A
H
--
V
D
I
--
L
V
I
D
S
AH
G
H
S
--
T
R
I
I
-----------------------------
E
----------------
L
I
K
K
I
K
T
---
K
Y
P
N
L
D
L
-
I
A
-
G
N
-
I
----
V
-----
T
K
-
E
A
A
L
------
D
L
I
-------
S
V
G
----
A
D
---
C
L
K
V
-
G
I
G
P
-----------------------
G
S
I
C
T
-
T
R
I
V
-
A
G
V
G
V
---
P
Q
I
T
A
I
C
D
V
Y
--
E
A
C
N
N
-
T
N
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
-----------
A
G
A
D
-----------
S
V
M
I
G
N
L
F
A
G
T
K
E
S
----
P
S
-
E
E
I
-
I
Y
N
G
K
K
F
K
S
M
V
-
P
-----------
Y
S
G
K
L
-------------
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
-
A
T
----
I
S
D
L
K
-
I
N
S
K
F
V
K
I
S
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
68.07
18%
-77
- C5 -
2UV8
1
?
G:
[581-924]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
I
G
R
P
-----
P
L
L
V
P
G
M
T
P
C
T
V
------
S
---
P
D
F
V
A
A
T
T
N
A
G
Y
T
I
E
L
A
G
G
G
Y
F
------------------------------------------
S
A
A
G
M
T
-
A
-
A
I
D
S
V
V
S
Q
--
I
E
K
G
-
S
T
F
G
I
N
L
-----
I
----
Y
----
V
-
N
-
P
----
F
M---
L
QWG
I
P
L
I
K
E
L
R
S
-
K
G
YP
I
Q
F
--
L
T
I
G
A
--
G
V
P
--
S
LE------------------------------
V
----------------
A
S
E
Y
I
E
T
-----
L
G
L
K
Y
-
L
--
G
L
K
P
----
G
-----
S
I
-
D
A
I
S
------
Q
V
I
N
I
A
----
K
A
H
----
P
N
FPI
A
L
Q
W
T
G
G
R
G
-----------------------
G
G
H
H
S
-
F
E
----
D
A
H
T
---
P
M
L
Q
M
Y
S
K
I
R
--
R
H
P
----
N
I
M
L
I
F
G
S
G
F
G
S
A
D
D
T
Y
P
Y
L
T
GEWSTKFDYPP
M
P
F
D
-----------
G
F
L
F
G
S
R
V
M
I
A
K
E
V
----
K
T
-
S
P
D
-
A
K
K
C
I
A
A
C
T
G
V
P
D
-----------
D
K
W
E
Q
TYKKPTGGIVTVR
S
E
M
G
E
P
I
H
K
I
A
T
R
G
V
M
L
W
K
E
F
D
E
TIFN
L
P
K
N
K
-
L
V
-
P
----------------
T
L
E
A
K
R
D
Y
I
I
S
R
-
L
N
A
D
F
Q
K
P
W
F
A
T
V
N
G
Q
A
R
-
D
L
AT
M
T
Y
E
E
V
A
K
R
L
V
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Fugue
68.02
18%
-62
- C5 -
2UV8
1
?
G:
[1-2033]
STRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKL
I
K
N
K
S
G
K
I
F
V
E
T
K
F
S
K
L
IGRP
P
L
L
V
P
G
M
T
P
C
T
V
------
S
---
P
D
F
V
A
A
T
T
N
A
G
Y
T
I
E
L
A
G
G
G
Y
-----------------------------------------
F
S
A
A
G
M
T
A
-
A
-
I
D
S
V
V
S
Q
I
--
E
-
K
G
-
S
T
F
G
I
N
L
-----
I
----
Y
VNPF
M
-
L
-
Q
----
W
----
G
---
I
P
L
I
K
E
L
R
S
-
K
G
--
Y
P
I
QF
L
T
I
G
A
--
G
V
P
--
S
--------------------------------------------------
L
E
V
A
S
E
---
Y
-
I
E
T
L
G
-
L
--
K
Y
-
L
----
G
LKPG-
S
I
-
D
A
I
S
------
Q
V
-
I
N
I
A
K
A
H
P
N
F
----
P
I
---
A
L
Q
W
T
G
G
R
G
-----------------------
G
G
H
H
S
-
F
E
-----------
D
A
H
T
P
M
L
Q
M
Y
--
S
K
I
R
R
H
P
N
I
M
L
I
F
G
S
G
F
G
S
A
D
D
T
Y
P
Y
L
T
-----------
G
E
W
S
TKFDYPPMPFD
G
F
L
F
G
S
R
V
M
I
A
K
E
V
KTSP
D
A
-
K
-
K
-
C
I
A
A
C
T
G
V
P
D
D
-
K
WEQTYKKPTGG
I
V
T
V
R
-------------
S
E
M
G
E
P
I
H
K
I
A
T
R
G
V
M
L
W
K
E
-
F
D
----
E
T
I
F
N
------
L
P
K
N
K
L
V
P
T
L
E
A
K
R
D
Y
I
I
S
R
L
N
-
A
D
F
------
Q
K
P
W
F
A
T
V
N
G
Q
A
R
D
L
A
T
--
M
T
Y
E
E
V
A
K
R
L
V
E
L
MFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQ
84
HHSearch
66.42
21%
-75
- C5 -
3FFS
-
IMDH_CRYPV
A:
[37-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
V
S
L
K
I
----
P
L
I
S
S
A
M
D
T
-
V
T
------
E
---
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N
M
D
M
E
---
S
Q
V
N
E
V
L
--
K
V
K
N
W
-----------
I
-------------------
A
-
Y
S
N
E
N
L
D
N
--
K
-
G
R
-
L
R
V
G
A
A
I
-----
G
----
V
-------------
N
--------
I
E
R
A
K
L
L
V
E
-
A
G
--
V
D
V
--
I
V
L
D
S
--
A
H
G
HS
L
--------------------------------
N
----------------
I
I
R
T
L
K
E
I
K
S
K
-
M
N
I
D
V
I
V
--
G
N
-
V
----
V
-----
T
E
-
E
A
T
K
------
E
L
I
-------
E
N
G
----
A
D
---
G
I
K
V
-
G
I
----------------------------------
I
V
A
G
V
G
V
---
P
Q
I
T
A
I
E
K
C
S
--
S
V
A
S
K
-
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
-----------
V
G
A
S
-----------
S
V
M
I
G
S
I
L
A
G
T
E
E
S
----
P
G
-
E
K
E
-
L
I
G
D
T
V
Y
K
Y
R
V
-
K
-----------
Y
K
G
E
M
-------------
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
-
A
S
----
I
E
E
L
W
-
K
K
S
S
Y
V
E
I
T
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
65.48
18%
-86
- C5 -
2NLI
3
?
A:
[72-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
L
G
H
K
I
K
A
----
P
F
I
M
A
P
I
A
A
-
H
G
LAHTTK
E
---
A
G
T
A
R
A
V
S
E
F
G
T
I
M
S
I
S
A
Y
S
G
A
T
------------------------------------------
F
E
E
------
I
S
E
G
L
------
N
G
-
G
P
R
W
F
Q
I
-----
Y
----
M
----
A
-
K
-
D
D
---
Q
Q
---
N
---
R
D
I
L
D
E
A
K
S
-
D
G
--
A
T
A
--
I
I
L
T
A
--
D
S
T
---NRDYPFGM
P
I
V
Q
R
YLRGTAEGMYGASKQKIS
P
R
----------------
D
I
E
E
I
A
G
---
H
-
S
G
L
P
V
-
F
--
V
K
G
I
----
Q
-----
H
P
-
E
D
A
D
------
M
A
I
-------
K
R
G
----
A
S
---
G
I
W
V
S
N
H
G
A
-----------------------
R
Q
L
Y
E
-
A
---------
P
--
G
S
F
D
T
L
P
A
I
A
--
E
R
V
N
--
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
-----------
S
G
A
D
-----------
V
V
A
L
G
R
P
V
L
F
G
L
A
L
----
G
G
-
W
-
Q
-
G
A
Y
S
V
L
D
Y
F
Q
K
-
D
-----------
L
T
R
V
M
-------------
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
-
Y
G
----
Y
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
64.81
22%
-80
- C5 -
1EP3
2
PYRDB_LACLM
A:
[8-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
L
P
G
L
D
L
K
N
----
P
I
I
P
A
S
G
C
F
-
G
F
------
G
---
E
E
Y
A
K
Y
Y
D
L
N
-
K
L
G
S
I
M
V
K
A
T
T
L
-
H
P
R
F
G
N
P
T
P
--
R
V
A
E
T
-----------
A
S
G
M
L
N
AI
G
L
Q
N
P
G
L
E
V
I
M
T
E
-
K
L
P
W
L
N
E
N
--
F
-
P
E
-
L
P
I
I
A
N
V
-----
A
----
G
----
S
-
E
-
E
A
---
D
----
Y
---
V
A
V
C
A
K
I
G
D
A
A
N
--
V
K
A
--
I
E
L
N
I
--
S
C
P
--
N
--------------------------------
V
KHGGQAFGTD
P
E
V
A
A
A
L
V
K
A
C
K
A
---
V
-
S
K
V
P
L
-
Y
--
V
K
-
L
----
S
PNVTD
I
V
-
P
I
A
K
------
A
V
E
-------
A
A
G
----
A
D
---
G
L
T
M
I
N
T
L
M
G
V
R
F
D
LKTRQPILANI
T
------
G
G
L
S
G
-
P
A
-
I
-----
K
P
--
V
A
L
K
L
I
H
Q
V
A
--
Q
D
V
----
D
I
P
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
-----------
A
G
A
S
-----------
A
V
A
V
G
T
A
N
F
A
D
P
F
V
----
C
P
-
K
-
I
-
I
D
K
L
P
E
L
M
D
Q
Y
-
R
-----------
I
E
S
L
E
-------------
S
L
I
Q
E
V
K
E
G
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.75
41%
-76
- C6 -
1B3O
2
IMDH2_HUMAN
A:
[347-396]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
V
S
--
E
Y
A
R
R
F
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
-----------
L
G
A
S
-----------
T
V
M
M
G
S
L
L
A
A
T
T
E
A
----
P
G
-
E
-
Y
-
D
K
G
S
I
H
K
F
V
P
Y
-
L
-----------
I
A
G
I
Q
-------------
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
-
G
E
----
L
K
F
E
K
-
R
T
S
S
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
62.98
16%
-95
- C5 -
3R2G
-
?
A:
[39-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
N
L
----
P
V
I
S
A
N
M
D
T
-
I
T
------
E
---
S
N
M
A
N
F
M
H
S
K
G
A
M
G
A
L
H
R
F
M
--------------------------------------------
T
I
E
E
N
I
-
Q
-
E
F
K
K
--------
C
K
-
G
P
V
F
V
S
V
-----
G
----
C
----
T
---
E
----
N
----
E
---
L
Q
R
A
E
A
L
R
D
-
A
G
--
A
D
F
--
F
C
V
D
V
--
A
H
A
--
H
A
K
Y
V
G
---------------------------
K
----------------
T
L
K
S
L
R
Q
---
L
-
L
G
S
R
C
-
I
M
A
G
N
-
V
----
A
-----
T
Y
-
A
G
A
D
------
Y
L
A
-------
S
C
G
----
A
D
---
I
I
K
A
-
G
I
G
G
-----------------------
G
S
V
C
S
-
T
R
I
K
-
T
G
F
G
V
---
P
M
L
T
C
I
Q
D
C
S
--
R
A
-----
D
R
S
I
V
A
D
G
G
I
K
T
S
G
D
I
V
K
A
L
A
-----------
F
G
A
D
-----------
F
V
M
I
G
G
M
L
A
G
S
A
P
T
----
P
G
-
E
V
F
-
Q
K
D
D
G
S
K
V
K
R
Y
-
R
-----------
G
M
A
S
R
-------------
E
A
Q
E
A
F
L
G
Q
M
H
E
W
K
T
A
E
G
V
A
-
T
E
----
V
P
F
K
E
-
N
P
D
G
I
I
A
D
I
I
G
G
L
R
S
G
L
T
Y
A
G
A
D
S
I
S
E
-
L
Q
R
K
-
L
N
Y
V
I
V
T
Q
A
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
62.70
13%
-97
- C5 -
1GTE
2
DPYD_PIG
A:
[535-822]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
M
A
G
L
K
F
I
N
----
P
F
G
L
A
S
A
A
P
-
T
T
------
S
---
S
S
M
I
R
R
A
F
E
A
G
-
W
G
F
A
L
T
K
T
F
S
L
D
K
D
I
V
T
N
V
S
P
--
R
I
V
R
G
TTSGPMYGPGQ
S
S
F
L
N
IE-
L
I
S
E
K
T
A
A
Y
W
C
-
Q
-
S
V
T
E
L
K
A
D
--
F
-
P
D
-
N
I
V
I
A
S
I
-----
M
----
C
----
S
Y
N
K
N
----
D
----
W
---
M
E
L
S
R
K
A
E
A
-
S
G
--
A
D
A
--
L
E
L
N
L
--
S
C
P
--
H
--------------------------------
G
MGLACGQD
P
E
L
V
R
N
--
I
C
R
W
V
R
Q
---
A
-
V
Q
I
P
F
-
F
--
A
K
-
L
T
PNV
T
-----
D
I
V
S
I
A
R
------
A
A
K
-------
E
G
G
----
A
D
---
G
V
T
A
T
N
T
V
S
G
L
MGLKADGTPWPAVGAGKRT
T
Y
G
G
V
S
G
-
T
A
-
I
-----
R
P
--
I
A
L
R
A
V
T
T
I
A
--
R
A
L
P
---
G
F
P
I
L
A
T
G
G
I
D
S
A
E
S
G
L
Q
F
L
H
-----------
S
G
A
S
-----------
V
L
Q
V
C
S
A
V
Q
N
Q
D
F
T
----
V
I
-
Q
-
D
-
Y
C
T
G
L
K
A
L
L
Y
L
-
K
-----------
S
I
E
E
L
-------------
Q
G
W
D
G
Q
S
P
G
T
E
S
H
Q
K
G
K
P
V
P
-
R
I
----
A
E
L
M
G
-
K
K
L
P
N
F
G
P
Y
L
E
Q
R
K
K
I
I
A
E
E
K
M
R
L
K
E
Q
-
N
E
R
K
-
P
F
I
P
K
K
P
I
P
A
I
K
D
V
I
G
K
A
-
L
Q
--
Y
L
G
T
F
G
E
L
S
N
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.62
27%
-64
- C6 -
4QIS
1
?
A:
[16-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
Q
----
P
I
I
Q
A
P
M
-
L
G
V
S
------
T
---
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
-----------
F
N
-------
V
N
L
F
C
H
R
P
G
Q
-
A
-
D
P
A
R
E
R
A
W
--
L
-
D
Y
L
K
P
L
F
A
E
F
GAEPP
V
----
R
----
L
-
K
-
N
----
I
----
Y
---
L
S
F
L
E
D
P
T
L
------------------
L
P
--
M
--------------------------------
L
----------------
L
E
E
R
P
A
A
---
V
-
S
F
H
F
G
-
A
--
P
P
-
R
----
D
-----
Q
V
-
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
---
A
V
V
A
Q
G
I
E
A
-----------------------
G
G
H
R
G
V
F
E
-
P
-
E
---
R
G
D
A
A
I
G
T
L
A
--
L
V
--
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
-----------
L
G
A
S
-----------
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
----
S
A
-
N
-
A
-
A
Y
R
E
A
L
K
G
P
R
A
-
A
-----------
R
T
A
L
T
-------------
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
-
A
P
----
G
V
P
P
L
-
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
-
Q
W
A
G
-
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
-
V
E
--
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.04
26%
-62
- C6 -
4QIT
2
?
A:
[17-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
Q
----
P
I
I
Q
A
P
M
-
L
G
V
S
------
T
---
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
-----------
F
N
-------
V
N
L
F
C
H
R
P
G
Q
-
A
-
D
P
A
R
E
R
A
W
--
L
-
D
Y
L
K
P
L
F
A
E
F
GAEPP
V
----
R
----
L
-
K
-
N
----
I
----
Y
---
L
S
F
L
E
D
P
T
L
------------------
L
P
--
M
--------------------------------
L
----------------
L
E
E
R
P
A
A
---
V
-
S
F
H
F
G
-
A
--
P
P
-
R
----
D
-----
Q
V
-
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
---
A
V
V
A
Q
G
I
E
A
-----------------------
G
G
S
R
G
V
F
E
-
P
-
E
---
R
G
D
A
A
I
G
T
L
A
--
L
V
--
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
-----------
L
G
A
S
-----------
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
----
S
A
-
N
-
A
-
A
Y
R
E
A
L
K
G
P
R
A
-
A
-----------
R
T
A
L
T
-------------
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
-
A
P
----
G
V
P
P
L
-
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
-
Q
W
A
G
-
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
-
V
E
--
E
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.73
27%
-60
- C6 -
4Q4K
1
?
A:
[11-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
Q
----
P
I
I
Q
A
P
M
-
L
G
V
S
------
T
---
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
-----------
F
N
-------
V
N
L
F
C
H
R
P
G
Q
-
A
-
D
P
A
R
E
R
A
W
--
L
-
D
Y
L
K
P
L
F
A
E
F
GAEPP
V
----
R
----
L
-
K
-
N
----
I
----
Y
---
L
S
F
L
E
D
P
T
L
------------------
L
P
--
M
--------------------------------
L
----------------
L
E
E
R
P
A
A
---
V
-
S
F
H
F
G
-
A
--
P
P
-
R
----
D
-----
Q
V
-
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
---
A
V
V
A
Q
G
I
E
A
-----------------------
G
G
H
R
G
V
F
E
-
P
-
E
---
R
G
D
A
A
I
G
T
L
A
--
L
V
--
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
-----------
L
G
A
S
-----------
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
----
S
A
-
N
-
A
-
A
Y
R
E
A
L
K
G
P
R
A
-
A
-----------
R
T
A
L
T
-------------
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
-
A
P
----
G
V
P
P
L
-
P
D
Y
P
F
V
Y
D
A
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
-
Q
W
A
G
-
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
-
V
E
--
E
L
R
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.50
26%
-67
- C6 -
2GJN
2
2NPD_PSEAE
A:
[44-210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
------
A
L
T
Q
P
S
P
E
A
L
A
-
A
-
E
I
A
R
C
R
E
L
--
T
--
D
-
R
P
F
G
V
N
L
-----
T
----
L
----
L
-
P
-
T
----
Q
KPVP
Y
---
A
E
Y
R
A
A
I
I
E
-
A
G
--
I
R
V
--
V
E
T
A
G
--
N
D
P
G
-
E
--------------------------------
H
----------------
I
A
E
F
R
R
H
---
G
-------
V
--
K
V
-
I
----
H
-----
K
C
-
T
A
V
R
------
H
A
L
K
--
A
E
R
L
G
------
V
D
---
A
V
S
I
D
G
F
E
C
-----------------------
A
G
H
P
G
----------------
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
-----------
L
G
A
D
-----------
A
I
N
M
G
T
R
F
L
A
T
R
E
C
----
P
I
-
H
-
P
-
A
V
K
A
A
I
R
A
A
D
E
-
R
-----------
S
T
D
L
I
-------------
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
-
A
I
----
E
A
R
G
G
-
A
G
Y
A
D
I
A
A
L
V
S
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
-
I
W
S
A
-
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
-
D
I
--
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------