@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0716: (2015-12-17 )
MKDFLEDYKKSVLERKSEGIPPLPLNAKQVEAVVEILMKDPTNAAFAKELLIHRVSPGVDEGAKVKAEFLAQLSQKKLECPHISALEATTLLGTMLGGYNVEPLIVGLESQDKNIAKESAKALKTTLLVYGSFDKIAAMSKTNALAKEVLESWANAEWFLNKEPLNECIEACVFKIDGETNTDDLSPASDAFTRSDIPLHAKAMLKNRIENYEQRIEAIKTKGVPVAYVGDVVGTGSSRKSATNSIMWHFGKDIPFVPNKRSGGIVIGGVIAPIFFATCEDSGALPIVADVKDLKEGDIIKIYPYKGEITLNDKVVSTFKLEPETLLDEVRASGRIPLIIGRGLTNKARKFLGLGESEAFKKPSAPKSDAKGYTLAQKIVGHACGVKGILPGAYCEPKVTTVGSQDTTGAMTRDEVKELASLKFDAPFVLQSFCHTAAYPKPSDVSLHATLPGFITQRGGVALHPGDGVIHTWLNRMGLPDTLGTGGDSHTRFPLGISFPAGSGLVAFAAVTGTMPLNMPESVLVRFKGEMNPGITLRDLVNAIPYYAIKKGLLTVEKKGKINVFNGRILEIEGLPDIKMEQAFELSDASAERSAAACVVRLNKEPMIEYLKSNIKLIDEMIASGYEDKETLKKRRDAMQAWVDKPVLLEPDSNAQYAAVIEIDVAEITEPILACPNDPDDVATLSEVLADTTGKRPHAIDEVFIGSCMTNIGHFRAFGEIVKNAPPSQARLWVVPPSKMDEQELINEGYYAIFGAAGARTEVPGCSLCMGNQARVRDNAVVFSTSTRNFDNRMGRGAKVYLGSAELGAACALLGRIPTKEEYMNLVSEKLESQKDKIYRYMNFNLMENFRL
Atome Classification :
(20 SA)
.........10........20........30........40..-..-....50........60........70........80........90........100.......110.......120.......130.......-140-.......150.......160.......170.......180.......190......----.200.......210----------.----------......220.......230.......240.......250.......260.......270.......280.......290.......300.......310..--.--......320.......330.......340.......350.......360.......370.......380.....---..--.390---.-......400.......410.......420-.-..-....-..------430..---------.------....440------...----..---------------..450.....-..460-...-.-...470.-.-..-----------..--.480.......490------....--.---...500...--....510.....--...520.......530.......540..---------.....550--......-.560.......570--.--......580.......590.......600.......610.......620.......630.......640-.....-..----650.......660.......670.......680......--.690..--------------------------------.-....700.......710--.-........-720---.------...----..-.----730.......740.......750.......760.......770---...---.-..----.--------.780-.........790....--.--..800.......810.....------------..820...------....830.......840.......850--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
D
F
L
E
D
Y
K
K
S
V
L
E
R
KSEGIPPLPL
N
A
K
Q
V
E
A
V
V
E
I
L
MKDPT
N
-
A
A
-
F
A
K
E
L
L
I
H
RVSPGVDE
G
A
K
V
K
A
E
F
L
A
Q
L
S
Q
KKLECPHI
S
A
L
E
A
T
T
L
L
G
T
M
LGGYNV
E
P
L
I
V
GLESQ
D
K
N
I
A
K
E
S
A
K
A
L
K
T
T
L
L
V
YGS
F
D
K
I
A
A
M
-
S
K
T
-
N
A
L
A
K
E
V
L
E
S
WANA
E
W
F
L
N
K
E
P
L
N
E
C
I
E
A
C
V
F
K
IDGETNTDDLSPASDAFTRSDIP----
L
H
A
K
A
M
L
K
N
R
I
E
N
Y
----------
E
----------
Q
R
I
E
A
I
KTKG
V
P
V
A
Y
V
GDVVGTGSSRKSA
T
N
S
I
M
W
H
FGKDIPFVPNKRSG
G
I
V
I
G
G
V
I
A
P
I
F
F
A
TCEDSGA
L
P
I
V
A
D
V
K
DLKEG
D
I
I
K
I
Y
PYK
G
E
I
T
--LN--D--
K
V
V
S
T
FKL
E
P
E
T
L
L
D
E
V
R
ASGR
I
P
L
I
I
GRGL
T
N
K
A
R
K
F
LGLGE
S
E
AFKKPSAPKSDAK
G
Y
T
L
A
Q
K
I
V
-
G
H
ACGV---KG--ILPG---A-YCEP
K
V
T
TVGSQDTTGAM
T
R
D
E
V
K
E
L
A
---S-LK-FDA
P
-
F
V
------
L
Q
S
F
C
---------
H
------TAAYPKP------SD
V
----
S
L
---------------
H
ATL
P
G
F
I
TQ-RG
G
V
A
-LHP-G-D
G
V
I
H
T
W
-
L
-NR-----------MG--LPDTLGTGGDSH
T
-------
R
F
P
L
--
G
---ISFPAGSG
L
--
V
A
F
A
A
-VTGTMP--LNM
P
E
S
V
L
V
R
FKGEMNPG
I
T
L
R
D
L
V
NAI---------
P
Y
Y
A
I
K
KG--
L
L
T
VEK-KG
K
I
N
VFN
G
R
I
L
E
I--E--GLPD
I
K
M
E
Q
A
FELSDASAERS
A
A
A
C
V
V
RLNK
E
P
M
I
E
Y
L
K
S
N
I
K
L
I
D
E
M
I
ASGYE
D
K
E
T
L
K
K
R
R
D
A
M
Q
A
W-VDK
P
V
-
L
L----EPDSNA
Q
Y
A
A
V
I
E
I
D
V
A
E
IT
E
P
I
LACPNDP
D
D
V
A
T
L
S
E
V
--
L
A
DTTG--------------------------------K-RPH
A
I
D
E
V
F
I
G
S
C
M
T
----N-I
G
H
F
R
A
F
G
-
E
I
V
---K------NAP----PS-Q----
A
R
L
W
V
VPPSKM
D
E
Q
E
L
I
NEG
Y
Y
A
I
FGAAGARTEVPGCSLCMG----NQ
A
---
R
-VR----D--------
N
A
---
V
V
F
STSTRN
F
D
N
RMGR--G--
A
K
V
Y
LGS
A
E
L
G
A
A
C
A
L
L
GRI------------P
T
K
E
E
Y
M
N
------
L
V
S
E
K
L
E
S
Q
K
D
K
I
Y
R
Y
MN
F
N
L
M
E
NFRL--------
1
PsiBlast_PDB
97.92
61%
-79
- C3 -
1L5J
2
ACNB_ECOLI
A:
[1-852]
---
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
-
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
--
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
-
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
----
L
H
A
L
A
M
L
K
N
A
R
E
G
I
----------
E
PDQPGVVGP
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
--
N
H
--
E
TG
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
-
G
R
A
C
G
V
---
K
G
--
I
R
P
G
---
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
-
L
V
------
M
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
------
V
D
V
----
N
T
---------------
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
-
L
R
P
-
G
-
D
G
V
I
H
S
W
-
L
-
N
R
-----------
M
L
--
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
--
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
-
A
T
G
V
M
P
--
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
--
L
L
T
V
E
K
-
K
G
K
K
N
I
F
S
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
-
L
A
N
P
E
-
L
L
----
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
--
Q
G
E
K
----------------------------------------
I
D
E
V
F
I
G
S
C
M
T
----
N
-
I
G
H
F
R
A
A
G
-
K
L
L
D
A
H
K
------
G
Q
L
----
P
T
-------
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
---
R
-
V
A
----
D
--------
G
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
------------
P
T
P
E
E
Y
Q
T
------
Y
V
A
Q
V
D
K
T
A
V
D
-
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
--------
21
PsiBlast_CBE
97.80
61%
-78
* C3 *
1L5J
2
ACNB_ECOLI
B:
[1-852]
---
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
-
E
E
E
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
--
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
-
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
----
L
H
A
L
A
M
L
K
N
A
R
E
G
I
----------
E
PDQPGVVGPI
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
--
N
H
--
E
TG
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
-
G
R
A
C
G
V
---
K
G
--
I
R
P
G
---
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
-
L
V
------
M
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
------
V
D
V
----
N
T
---------------
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
-
L
R
P
-
G
-
D
G
V
I
H
S
W
-
L
-
N
R
-----------
M
L
--
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
--
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
-
A
T
G
V
M
P
--
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
--
L
L
T
V
E
K
-
K
G
K
K
N
I
F
S
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
-
L
A
N
P
E
-
L
L
----
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
--
Q
G
E
K
----------------------------------------
I
D
E
V
F
I
G
S
C
M
T
----
N
-
I
G
H
F
R
A
A
G
-
K
L
L
DAH
K
------
G
Q
L
----
P
T
-------
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
---
R
-
V
A
----
D
--------
G
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
------------
P
T
P
E
E
Y
Q
T
------
Y
V
A
Q
V
D
K
T
A
V
D
-
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
--------
33
Fugue
97.77
62%
-79
- C3 -
1L5J
2
ACNB_ECOLI
A:
[1-862]
---
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
-
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
--
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
-
A
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
----
L
H
A
L
A
M
L
K
N
A
R
E
G
I
EPDQPGVVGP
I
----------
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
N
H
E
T
--
G
--
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
-
G
R
A
C
G
V
---
K
G
--
I
R
P
G
---
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
-
L
V
------
M
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
------
V
D
V
----
N
T
---------------
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
-
L
R
P
-
G
-
D
G
V
I
H
S
W
-
L
-
N
R
-----------
M
L
--
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
--
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
-
A
T
G
V
M
P
--
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
--
L
L
T
V
E
K
-
K
G
K
K
N
I
F
S
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
-
L
A
N
P
E
-
L
L
----
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
------------------------------------------
Q
G
E
K
I
D
E
V
F
I
G
S
C
M
T
----
N
-
I
G
H
F
R
A
A
G
-
K
L
L
---
D
------
A
H
K
G---
Q
L
-
P
----
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
---
R
-
V
A
----
D
--------
G
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
------------
P
T
P
E
E
Y
Q
T
------
Y
V
-
A
Q
V
D
K
T
A
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
A
D
G
VIFQ
22
HHSearch
96.67
61%
-78
- C3 -
1L5J
2
ACNB_ECOLI
A:
[1-854]
---
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
G
I
A
P
K
P
L
D
A
N
Q
M
A
A
L
V
E
L
L
K
N
P
P
A
G
E
E
E
-
F
L
L
D
L
L
T
N
R
V
P
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
G
Y
N
I
H
P
L
I
D
A
L
D
--
D
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
K
A
G
-
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
L
K
N
A
R
E
G
I
E
P
D
Q
----------
P
GVVGP
I
----
K
Q
I
E
A
L
Q
Q
K
G
F
P
L
A
Y
V
G
D
V
V
G
T
G
S
S
R
K
S
A
T
N
S
V
L
W
F
M
G
D
D
I
P
H
V
P
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
F
F
N
T
M
E
D
A
G
A
L
P
I
E
V
D
V
S
N
L
N
M
G
D
V
I
D
V
Y
P
Y
K
G
E
V
R
--
N
H
ET
G
--
E
L
L
A
T
F
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
-
G
R
A
C
G
V
---
K
G
--
I
R
P
G
---
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
-
L
V
------
M
Q
S
F
C
---------
H
------
T
A
A
Y
P
K
P
------
V
D
V
----
N
T
---------------
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
-
L
R
P
-
G
-
D
G
V
I
H
S
W
-
L
-
N
R
-----------
M
L
--
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
F
P
I
--
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
-
A
T
G
V
M
P
--
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
--
L
L
T
V
E
K
-
K
G
K
K
N
I
F
S
G
R
I
L
E
I
--
E
--
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
-
L
A
N
P
E
-
L
L
----
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
--
Q
G
----------------------------------------
E
K
I
D
E
V
F
I
G
S
C
M
T
----
N
-
I
G
H
F
R
A
A
G
-
K
L
L
---
D
------
A
H
K
----
G
Q
L
P
----
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
---
R
-
V
A
----
D
--------
G
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
------------
P
T
P
E
E
Y
Q
T
------
Y
V
A
Q
-
V
D
K
T
A
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
--------
34
Fugue
74.60
70%
-97
- C3 -
1L5J
2
ACNB_ECOLI
A:
[380-822]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
F
S
L
A
Q
K
M
V
-
G
R
A
C
G
V
-----KG
I
R
P
G
---
A
-
Y
C
E
P
K
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
A
---
C
-
L
G
-
F
S
A
D
-
L
V
------
M
Q
S
F
C
---------
H
TAAYPK------
P
------
V
D
V
----
N
T
---------------
H
H
T
L
P
D
F
I
M
N
-
R
G
G
V
S
-
L
R
P
-
G
-
D
G
V
I
H
S
W
-
L
-
N
R
-----------
M
L
--
L
P
D
T
V
G
T
G
G
D
S
H
T
-------
R
--
F
P
I
G
---
I
S
F
P
A
G
S
G
L
--
V
A
F
A
A
-
A
T
G
V
M
P
--
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
---------
P
L
Y
A
I
K
Q
G
--
L
L
T
V
E
K
-
K
G
K
K
N
I
F
S
G
R
I
L
E
I
E
G----
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
N
K
E
P
I
I
E
Y
L
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
T
L
E
R
R
I
Q
G
M
E
K
W
-
L
A
N
P
E
-
L
L
----
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
P
I
L
C
A
P
N
D
P
D
D
A
R
P
L
S
A
V
--
Q
G
----------------------------------------
E
K
I
D
E
V
F
I
G
S
C
M
-----
T
N
I
G
H
F
R
A
A
G
-
K
L
L
---
D
------
A
-------
H
-
K
GQLP
T
R
L
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
----
N
Q
A
---
R
---VADG----------
A
---
T
V
V
S
T
S
T
R
N
F
P
N
R
L
G
T
--
G
--
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
------------
P
T
P
E
E
Y
Q
T
------
Y
V
A
Q
V
D
K
T
A
V
D
T
Y
R
Y
L
N
F
N
Q
L
S
Q
Y
T
E
K
--------
23
HHSearch
55.08
22%
-59
- C3 -
1C96
3
ACON_BOVIN
A:
[30-482]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
R
P
L
T
L
S
E
K
I
V
-
Y
G
H
L
D
D
PAN
Q
E
--
I
E
R
G
---
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
---
L
P
K
V
-
A
V
P
S
-
T
I
--------
H
C
D
---------
H
------
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
---------------
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
F
-
W
R
P
-
G
-
S
G
I
I
H
Q
I
-
I
-
L
E
N----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
LG
G
I
C
I
G
V
G
G
A
D
--
A
V
D
V
M
-
A
G
I
P
W
E
--
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
-------------
A
G
I
L
-----------
T
V
K
G
G
T
G
A
I
V
E
Y
--
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
-
K
K
Y
L
S
K
T
----------
G
R
A
D
I
A
N
L
------
A
D
E
F
----
K
D
-
H
L
----
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
--
G
S
V
A
E
K
E
-------------------------------
G
-
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
----
S
S
Y
E
D
M
G
R
S
A
-
A
V
A
---
K
Q
A
L
A
H
-
G
L
K
----
C
--
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
RKD
I
K
K
G
----
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
NP
E
--
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
2
PsiBlast_PDB
54.34
26%
-69
- C3 -
4KP2
-
HACA_METJA
A:
[23-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
V
E
K
I
L
-
S
K
K
V
G
Y
---
E
---
V
C
A
G
---
D
-
S
I
E
V
E
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
S
---
D
-
S
V
-
W
N
P
D
-
K
I
------
V
V
A
F
D
---------
H
------
N
V
P
P
N
T
V
------
K
A
A
----
E
M
---------------
Q
K
L
A
L
E
F
V
K
R
-
F
G
I
K
N
-
F
H
K
-
G
G
E
G
I
C
H
Q
I
-
L
A
E
N
-----------
Y
V
--
L
P
N
M
F
V
A
G
G
D
S
H
T
CT-----
H
G
A
F
--
G
----
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
-
A
T
G
E
T
W
--
I
K
V
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
---------
C
K
E
I
G
R
R
G
AT
Y
M
A
I
E
Y
-
G
G
E
V
----------------
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
A
D
-
E
I
T
Y
D
Y
L
K
K
E
R
G
L
S
D
E
D
I
A
K
-------
L
K
K
E
R
-----------
I
-
T
V
----
N
R
D
E
-
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
E
E
Q
V
-
A
V
P
H
H
P
D
N
V
K
P
I
S
D
V
------------------------------------------
E
G
T
E
I
N
Q
V
F
I
G
S
C
T
N
G---
R
-
L
S
D
L
R
E
A
A
-
K
Y
L
---
K
------
G
R
E
----
V
H
-
K
D---
V
K
L
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A---
H
Q
G
---
V
-
L
A
----
E
--------
G
E
---
I
C
L
S
T
T
N
R
N
F
K
G
R
M
G
H
I-
N
--
S
Y
I
Y
L
A
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
------------
T
N
K
----------------------------------------------
4
PsiBlast_PDB
53.67
26%
-60
- C3 -
4KP1
6
LEUC_METJA
A:
[23-439]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
T
I
V
E
K
I
L
-
A
K
A
S
G
K
---
K
E
--
V
S
P
G
---
D
-
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
---
I
-
E
K
-
V
W
N
P
E
K
I
------
V
I
L
F
D
---------
H
------
Q
V
P
A
D
S
I
------
K
A
A
----
E
N
---------------
H
I
L
M
R
K
F
V
K
E
-
Q
G
I
K
Y
-
F
Y
D
I
R
-
E
G
V
C
H
Q
V
-
L
-
P
E
-----------
K
G
HV
A
P
G
E
V
V
V
G
A
D
S
H
T
CTHGAFG
A
F
A
T
--
G
---
I
----
G
S
T
D
--
M
A
H
V
F
-
A
T
G
K
L
W
--
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
I
G
E
V
GVDGA
T
Y
K
A
C
Q
F
G
--
G
E
T
V
K
K
-
M
-------------------------------
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
D
E
K
T
I
Q
Y
V
----------
K
E
A
M
K
K
H
------
G
-
T
E
R
P
F
E
V
I
----
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
--
A
G
--------------------------------------
K
P
--
I
D
Q
V
F
I
G
S
C
T
N
----
G
R
L
E
D
L
R
M
A
I
-
K
I
I
---
E
K
H
----
G
G
I
----
A
D
-
D
----
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
L
Y
---
G
-
V
L
----
G
P-------
G
E
---
V
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
S
L-
E
--
A
E
I
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
L
------------
V
D
P
R
D
L
-------------------------------------------
3
PsiBlast_PDB
52.65
26%
-56
- C3 -
4NQY
1
LEUC_METJA
A:
[22-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
V
E
K
I
L
-
A
K
A
S
G
K
---
K
E
--
V
S
P
G
---
D
-
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G
---
I
-
E
K
-
V
W
N
P
E
K
I
------
V
I
L
F
D
-------------------------------------
N
---------------
H
I
L
M
R
K
F
V
K
E
-
Q
G
I
K
Y
-
F
Y
D
I
R
-
E
G
V
C
H
Q
V
-
L
-
P
E
-----------
K
G
HV
A
P
G
E
V
V
V
G
A
D
S
H
T
CTHGAFG
A
F
A
T
--
G
---
I
----
G
S
T
D
--
M
A
H
V
F
-
A
T
G
K
L
W
--
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
---------
I
-----------------
G
E
V
G
V
----------------
D
G
A
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
--
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-------
D
E
K
T
I
Q
Y
V
K
E
A
M
K
K
H
G
T
E
R
P
F
E
V
I
----
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
P
V
F
A
C
P
H
N
V
D
N
V
K
Q
A
R
E
V
--
A
G
--------------------------------------
K
P
--
I
D
Q
V
F
I
G
S
C
T
N
----
G
R
L
E
D
L
R
M
A
I
-
K
I
I
---
E
K
H
----
G
G
I
----
A
D
-
D
----
V
R
V
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
----
S
L
Y
---
G
-
V
L
----
G
P-------
G
E
---
V
C
V
S
T
S
N
R
N
F
R
G
R
Q
G
S
L-
E
--
A
E
I
Y
L
A
S
P
I
T
A
A
A
C
A
V
K
G
E
L
------------
V
D
P
R
D
--------------------------------------------
35
Fugue
50.72
20%
-49
- C3 -
1ACO
2
?
?:
[2-528]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
K
V
A
M
S
H
F
E
P
H
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
---
A
N
--
Q
E
I
E
R
G
K
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
---
L
-
P
K
-
V
A
V
P
-
S
T
------
I
H
C
D
H
L
I
E
A
Q
LGG
E
K
------
D
L
R
R
A
K
D
------
I
N
Q
----
E
V
---------------
Y
N
F
L
A
T
A
G
A
K
-
Y
G
V
G
F
-
W
R
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
LG
G
I
C
I
G
V
G
G
A
D
--
A
V
D
V
M
-
A
G
I
P
W
E
--
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------
A
G
I
L
T
V
K
G
--
G
-------------
T
G
A
I
V
E
Y
H
G
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
-
H
R
M
K
K
Y
L
S
K
-------------------
T
G
R
A
D
I
A
N
L
A
-
D
E
F
K
D
-
H
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
--
G
S
V
A
E
K
--------------------------------
E
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
----
S
S
Y
E
D
M
G
R
S
A
-
A
V
A
---
K
------
Q
A
L
A
H
GL
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
QWDR
K
D
I
---
K
-
K
G
----
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
KFNPE
T
D
F
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
--------
24
HHSearch
49.81
19%
-59
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[58-568]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
E
N
I
L
-
H
W
N
V
T
--------
Q
H
K
N
---
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
-
K
L
G
G
D
P
E
-
K
I
NPV
C
P
A
D
L
V
I
D
---------
H
------
S
I
Q
V
D
F
N
------
R
R
A
----
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
-
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
-
G
-
S
G
I
I
H
Q
V
-
N
-
L
E
YLARVVFDQDG
Y
Y
--
Y
P
D
-
S
L
V
G
T
D
S
H
T
-------
T
M
I
D
--
G
LGI
L
G
W
G
V
G
G
I
E
--
A
E
A
V
M
-
L
G
Q
P
I
S
--
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
-------------
T
K
H
L
-----------
R
Q
V
G
V
V
G
K
F
V
E
F
--
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
-
I
T
Y
L
V
Q
T
----------
G
R
D
E
E
-----
K
L
K
Y
I
K
K
Y
-
L
Q
A
V
G
-
M
F
RDFN
D
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
--
K
K
D
F
E
S
C
L
G
AKQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
DN
T
E
F
T
L
-
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
----
T
S
N
P
S
V
M
L
G
A
-
G
L
L
---
A
K
K
A
V
D
A
G
L
N
----
V
M
P
Y
----
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
G
---
P
-
L
P
----
E
P
V
V
E
A
I
T
Q
G
D
LV
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N-
T
--
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
------------
R
I
D
F
E
K
E
P
------
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
--------
14
PsiBlast_PDB
49.57
22%
-60
- C3 -
1B0K
3
ACON_PIG
A:
[140-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
6
PsiBlast_PDB
49.49
22%
-60
- C3 -
1AMJ
2
ACON_BOVIN
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
8
PsiBlast_PDB
49.46
22%
-60
- C3 -
1FGH
2
ACON_BOVIN
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
9
PsiBlast_PDB
49.06
22%
-59
- C3 -
8ACN
2
ACON_BOVIN
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
18
PsiBlast_PDB
48.89
22%
-58
- C3 -
7ACN
2
ACON_PIG
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
12
PsiBlast_PDB
48.81
22%
-62
- C3 -
1B0J
2
ACON_PIG
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
5
PsiBlast_PDB
48.78
22%
-59
- C3 -
1AMI
2
ACON_BOVIN
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
19
PsiBlast_PDB
48.77
22%
-57
- C3 -
1C96
3
ACON_BOVIN
A:
[140-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------
11
PsiBlast_PDB
48.75
22%
-59
- C3 -
1NIT
2
ACON_BOVIN
A:
[141-478]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
-
S
G
I
I
H
Q
I
I
L
-
E
N
-----------
Y
A
--
Y
P
G
V
L
L
I
G
T
D
S
H
T
-------
P
N
G
G
--
G
---
L
G
G
I
C
I
G
V
G
--
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
---------------
A
G
--
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
-------
P
--
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
-
M
K
K
Y
L
S
K
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
---------------------
L
----
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
----------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
SS
Y
E
D
-
M
G
R
S
A
A
V
A
K
Q
A
L
---
A
------
H
G
L
----
K
C
-
K
----
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----
Q
W
D
---
R
-
K
D
IKKG
E
--------
K
N
---
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
--
N
PE
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
------------
K
F
N
P
E
T
D
F
------
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
--------