@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0901: (2015-12-19 )
MEIDKTECSTLLASIQKQQLVIPVVGNFSAGKSTLLNRFLGSSVLPTGITPETSLATELHYSANERIEAFSSNDEKTESFELNEQSFEAIKENAAKYSYLKVYLNNEALKDSAPLVFVDMPGFDSPISSHTHAILEYLERGVHFVILTSVEEGNLTKRMVRELKTF
Atome Classification :
(20 SA)
-------------------------------------------------.......---------------..10........20........30........40.-----....--..---------.50........60........70----------.........-80.---------.......90---...---------.....--------.-------------100.......110.-......120......--.130.....----..140........150.......160....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------MEI
D
K
T
E
---------------
C
S
T
L
L
A
S
I
QKQ
Q
L
V
I
P
V
VGNFSA
G
K
S
T
L
L
N
R
F
LGS-----SVLP--TG---------ITPET
S
L
A
T
E
L
HYSANER
I
E
AF-----------SSNDEKTE
S
-
F
EL---------
N
E
Q
S
F
E
A
I
----
K
E
N---------AAK
Y
S
--------
Y
-------------
L
K
V
Y
LNNEALKDSA-
P
L
V
F
V
DMPGFDSP
I
S
--
S
H
T
H
A
I
L
E
Y
----
L
ER-GV
H
F
V
I
L
T
SVEEG
N
L
T
K
R
M
V
R
E
L
KTF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
74.20
19%
-92
- C9 -
2J69
-
BDLP_NOSP7
A:
[4-695]
--QV
A
T
D
R
F
I
Q
D
L
E
R
V
A
Q
V
R
S
E
M
S
V
C
L
N
K
L
A
E
T
I
N
K
A
E
L
A
G
D
SSSGKLS
L
E
R
D
I
E
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
D
---------
V
N
P
C
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
T
I
H
-----------
F
N
D
G
K
S
P
Q
Q
-
L
D
F
---------
Q
N
F
K
Y
K
Y
T
----
I
D
P
---------
A
E
A
K
K
--------
L
E
Q
E
KKQAFPDVD
Y
A
V
V
E
Y
P
L
T
L
L
Q
K
G
---
I
E
I
V
D
S
P
G
L
N
D
-
T
E
--
A
R
N
E
L
S
L
G
Y
----
V
N
N
--
C
H
A
I
L
F
V
M
R
A
S
Q
P
C
T
L
G
E
R
R
Y
L
E
N
Y
IKGRG
L
T
V
F
F
L
VNAWDQVRESLIDPDD
V
E
E
L
Q
A
S
E
N
R
L
R
Q
V
F
N
A
N
LAEYCTVEGQNIYDER
V
F
E
L
S
S
I
Q
A
L
R
R
R
L
K
NPQADLDGTG
F
P
K
F
M
D
S
L
N
T
F
L
TRE
R
A
I
A
E
L
R
Q
V
R
T
L
A
R
L
A
C
N
H
T
R
E
A
V
A
R
R
I
P
L
L
EQDV
N
E
L
K
K
R
I
D
S
V
E
P
E
F
N
K
L
T
G
I
R
D
E
F
Q
K
E
I
I
N
T
R
D
T
Q
A
R
T
I
S
E
S
F
R
S
Y
V
L
N
LGNT
F
E
N
D
F
L
R
Y
Q
P
E
L
N
L
FDFLS
S
G
K
R
E
A
F
N
A
A
L
Q
K
A
F
E
Q
Y
I
T
D
K
S
A
A
W
T
L
T
A
E
K
D
I
N
A
A
F
K
E
L
S
R
S
A
S
Q
Y
G
A
S
Y
N
Q
I
T
D
Q
I
T
E
K
L
TGKDVEEDNSP
G
W
A
K
W
A
M
GLLSAGFD
W
K
N
I
L
L
N
Y
F
T
V
I
GIGGII
T
A
V
T
G
I
L
L
G
P
I
G
F
A
L
L
G
L
GVGFLQ
A
D
Q
A
R
R
E
L
V
K
T
A
K
K
E
L
V
K
H
L
P
Q
V
A
H
E
Q
S
Q
V
V
Y
N
A
V
K
E
C
F
D
S
Y
E
R
E
V
S
K
R
I
N
D
D
I
V
S
R
K
S
E
L
D
N
L
V
K
Q
K
Q
TREIN
R
E
S
E
F
N
R
L
K
N
L
Q
E
D
V
I
A
Q
L
Q
K
I
E
A
A
Y
S
N
L
L
A
Y
Y
S
H
H-----------------------------------------------------------------
51
HHSearch
70.52
19%
-85
* C9 *
2J69
-
BDLP_NOSP7
A:
[57-223]
-------------------------------------------------------
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
D
---------
V
N
P
C
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
T
I
H
-----------
F
N
D
G
K
S
P
Q
Q
-
L
D
F
Q
N
F
K
Y
K
Y
TI
D
P
A
E
A
K
K
L
E
Q
E
K
K
Q
A
---------
F
P
D
V
D
--------
Y
-------------
A
V
V
E
Y
P
L
T
L
L
Q
K
G
---
I
E
I
V
D
S
P
G
L
N
D
T
E
A
---
R
N
E
L
S
L
G
Y
----
V
N
N
-
C
H
A
I
L
F
V
M
R
A
-
S
Q
P
C
T
L
G
E
R
R
Y
L
E
N
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
70.26
27%
-43
- C7 -
3ZVR
3
DYN1_RAT
A:
[25-763]
-----------------------------------------GMED
L
I
P
L
V
N
R
L
Q
D
A
---------------
F
S
A
I
G
Q
N
A
D
L
D
L
P
Q
I
A
V
V
G
G
Q
S
A
G
K
S
S
V
L
E
N
F
V
G
R
-----
D
F
L
P
RG
S
G
---------
I
V
T
R
R
P
L
V
L
Q
L
V
N
S
T
T
E
Y
A
E
F
L
-----------
H
C
K
G
K
K
F
T
D
-
F
E
E
---------
V
R
L
E
I
E
A
E
----
T
D
R
---------
V
T
G
T
N
K
G
I
S
P
V
P
I
N
-------------
L
R
V
Y
S
P
H
V
L
------
N
L
T
L
V
D
L
P
G
-------------------------------
M
T
K
V
P
V
G
D
Q
P
P
D
I
E
F
Q
I
R
D
M
L
M
Q
F
VTKENCLIL
A
V
S
P
ANSDLANS
D
A
L
K
I
A
K
E
V
DPQGQR
T
I
G
V
I
T
KLDLMDEGTDA
R
D
V
L
E
NKLLPLRR
G
Y
I
G
V
V
N
R
SQKDIDGKKD
I
T
A
A
L
A
A
E
R
K
F
F
L
S
HPSYRHLADRMG
T
P
Y
L
Q
K
V
L
N
Q
Q
L
T
N
H
I
R
D
T
L
P
G
L
R
N
K
L
Q
S
Q
L
L
S
I
E
K
E
V
D
E
Y
K
N
F
R
PDDPAR
K
T
K
A
L
L
Q
M
V
Q
Q
F
A
V
D
F
E
K
R
I
E
GLS
G
G
A
R
I
N
R
I
F
HE
R
F
P
F
E
L
V
K
M
EFD
E
K
E
L
R
R
E
I
S
Y
A
I
K
N
I
HF
T
P
D
L
A
F
E
A
T
V
K
K
Q
V
Q
K
L
K
E
P
S
I
K
C
V
D
M
V
V
S
E
L
T
S
T
I
R
K
C
S
E
KLQQY
P
R
L
R
E
E
M
E
R
I
V
T
T
H
I
R
E
R
E
G
R
T
K
E
Q
V
M
L
L
I
D
I
E
L
A
YMNTNHEDFIGFILVI
R
K
G
W
L
T
I
NNIGIMS
K
E
Y
W
F
V
L
T
AENLSWYKDDEEKEKK
Y
M
L
S
VDN
L
K
L
R
D
VK
H
I
F
A
L
F
N
TEQRNVYKDYR
Q
L
E
L
A
C
E
T
Q
E
E
V
D
S
W
K
A
S
F
L
R
A
GVYPEP
Q
L
E
R
Q
V
E
T
I
R
N
L
V
D
S
Y
M
A
I
V
N
K
T
V
R
D
L
M
P
K
T
I
M
H
LM
I
N
N
T
K
E
F
I
F
SE
L
L
A
N
L
Y
S
C
GD
Q
N
T
L
M
EES
A
E
Q
A
Q
R
R
D
E
M
L
R
M
Y
H
A
L
K
E
A
L
S
I
I
G
2
PsiBlast_PDB
67.37
24%
-78
- C10 -
2J69
-
BDLP_NOSP7
A:
[51-179]
-------------------------------------------------
L
E
R
D
I
E
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
D
---------
V
N
P
C
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
-
T
I
-----------
H
F
N
D
G
K
S
P
Q
--
Q
L
---------
D
F
Q
N
F
---------------------
K
Y
K
--------
Y
-------------
T
I
D
P
A
E
A
K
K
L
E
Q
E
K
-
K
Q
A
F
P
D
V
D
------------
Y
A
V
V
E
Y
PL
T
L
L
Q
K
-
G
I
E
I
V
D
S
P
G
L
N
D
T
E
A
R
N
E
L
S
L
G
Y
V
N
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.04
24%
-93
- C10 -
2W6D
1
BDLP_NOSP7
A:
[51-179]
-------------------------------------------------
L
E
R
D
I
E
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
--------------
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
-
T
I
-----------
H
F
N
D
G
K
S
P
Q
--
Q
L
---------
D
F
Q
N
F
---------------------
K
Y
K
--------
Y
-------------
T
I
D
P
A
E
A
K
K
L
E
Q
E
K
-
K
Q
A
F
P
D
V
D
------------
Y
A
V
V
E
Y
PL
T
L
L
Q
K
-
G
I
E
I
V
D
S
P
G
L
N
D
T
E
A
R
N
E
L
S
L
G
Y
V
N
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.35
24%
-94
- C10 -
2J68
1
BDLP_NOSP7
A:
[51-179]
-------------------------------------------------
L
E
R
D
I
E
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
--------------
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
-
T
I
-----------
H
F
N
D
G
K
S
P
Q
--
Q
L
---------
D
F
Q
N
F
---------------------
K
Y
K
--------
Y
-------------
T
I
D
P
A
E
A
K
K
L
E
Q
E
K
-
K
Q
A
F
P
D
V
D
------------
Y
A
V
V
E
Y
PL
T
L
L
Q
K
-
G
I
E
I
V
D
S
P
G
L
N
D
T
E
A
R
N
E
L
S
L
G
Y
V
N
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
61.77
16%
-80
- C9 -
2QPT
3
EHD2_MOUSE
A:
[26-545]
----------------------------RT
V
T
S
S
L
K
E
L
Y
R
T
KL
L
P
L
E
E
H
Y
R
F
G
S
F
H
---------------
S
P
A
L
E
D
A
D
F
D
G
K
P
M
V
L
V
A
G
Q
Y
S
T
G
K
T
S
F
I
Q
Y
L
L
E
Q
-----
E
V
P
G
S
R
V
G
---------
P
E
P
T
T
D
C
F
V
A
V
M
H
G
E
T
E
G
T
V
P
G
-----------
N
T
F
L
N
R
F
M
C
-
A
Q
L
---------
P
N
Q
V
L
E
S
I
------------------------------------------------------------
S
I
I
D
T
P
G
I
L
S
R
G
Y
--
D
F
P
A
V
L
R
W
F
----
A
E
R
-
V
D
L
I
I
L
L
F
D
A
H
K
L
E
I
S
D
E
F
S
E
A
I
G
A
L
RGHEDK
I
R
V
V
LNKADMVE
T
Q
Q
L
M
R
V
Y
G
A
L
M
W
A
L
G
K
V
VGTP
E
V
L
R
V
Y
I
G
S
FWSQPLLVPDN
R
R
L
F
E
L
E
E
Q
D
L
F
R
D
I
Q
G
LPRH
A
A
L
R
K
L
N
D
L
V
K
R
A
R
L
V
R
V
H
A
Y
I
I
S
Y
L
K
K
E
MPTVFG
K
E
N
K
K
K
Q
L
I
L
K
L
P
V
I
F
A
K
I
Q
L
E
HHISPGDFPD
C
Q
K
M
Q
E
L
L
M
A
HDFTKFHSLK
P
K
L
L
E
A
L
D
D
M
L
A
Q
D
I
A
K
L
M
P
L
L
R
Q
E
E
L
ESVEAGVAGGAFEGTRMGPFVEWVVTKD
K
S
K
Y
D
E
I
F
Y
N
L
APADGKLS
G
S
K
A
K
T
W
M
V
G
T
KLP
N
S
V
L
G
R
I
W
K
L
S
DVDRDGMLD
D
E
E
F
A
L
A
S
H
L
I
E
A
K
L
E
G
H
G
L
P
TNLPRRLVPPSKRRQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.13
39%
-116
- C10 -
3W6P
4
DNM1L_HUMAN
A:
[25-91]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
W
G
K
F
L
-----------
H
T
K
N
K
L
Y
T
D
-
F
D
E
---------
I
R
Q
E
I
E
N
E
----
T
E
R
---------
I
S
G
N
N
--------
K
-------------
G
V
S
P
E
P
I
H
L
K
I
F
S
P
-
N
V
V
N
L
T
L
V
D
L
P
G
M
T
K
--
V
P
V
G
D
Q
P
K
D
----
I
E
L
-
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
A
V
T
A
A
N
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Fugue
54.01
16%
-50
- C9 -
2W6D
16
BDLP_NOSP7
A:
[2-695]
VNQV
A
T
D
R
F
I
Q
D
L
E
R
V
A
Q
V
R
S
E
M
S
V
C
L
N
K
L
A
E
T
I
N
K
A
E
L
A
GDSSSGKLS
L
E
R
D
I
E
D
---------------
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
-----
N
L
L
P
--
S
--------------
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
T
I
H
F
NDGKSP
Q
Q
L
D
F
Q
N
F
K
Y
K
Y
T
-
I
D
P
---------
A
E
A
K
K
L
E
Q
----
E
K
K
---------
Q
A
F
P
D
--------
V
-------------
D
Y
A
V
V
E
Y
P
L
T
L
L
Q
K
-
G
I
E
I
V
D
S
P
G
L
N
D
T
E
A
--
R
N
E
L
S
L
G
Y
V
----
N
N
C
-
H
A
I
L
F
V
M
R
A
------
S
Q
P
C
T
L
G
E
R
R
Y
L
E
N
YIKGRG
L
T
V
F
F
L
VNAWDQVRESLIDPDD
V
E
E
L
Q
A
S
E
N
R
L
R
Q
V
F
N
A
N
LAEYCTVEGQNIYDER
V
F
E
L
S
S
I
Q
A
L
R
R
R
L
K
NPQADLDGTG
F
P
K
F
M
D
S
L
N
T
F
L
TRE
R
A
I
A
E
L
R
Q
V
R
T
L
A
R
L
A
C
N
H
T
R
E
A
V
A
R
R
I
PLLEQDV
N
E
L
K
K
R
I
D
S
V
E
P
E
F
N
K
L
T
G
I
R
D
E
F
Q
K
E
I
I
N
T
R
D
T
Q
A
R
T
I
S
E
S
F
R
S
Y
V
L
N
L
G
N
T
F
E
N
D
F
L
R
Y
QPELNLFDFLSSGKRE
A
F
N
A
A
L
Q
K
A
F
E
Q
Y
I
T
D
K
S
A
A
W
T
L
T
A
E
K
D
I
N
A
A
F
K
E
L
S
R
S
A
S
Q
Y
G
A
S
Y
N
Q
I
T
D
Q
I
T
E
K
L
TGKDVEDNSP
G
W
A
K
W
A
M
GLLSLSKGNLAGFALAGAGFD
W
K
N
I
L
L
N
Y
F
T
V
I
G
I
G
G
I
I
T
A
V
T
G
I
L
L
G
P
I
G
F
A
L
L
G
L
G
V
GFLQAD
Q
A
R
R
E
L
V
K
T
A
K
K
E
L
V
K
H
L
P
Q
V
A
H
E
Q
S
Q
V
V
Y
N
A
V
K
E
C
F
D
S
Y
E
R
E
V
S
K
R
I
N
D
D
I
V
S
R
K
S
E
L
D
N
L
V
K
Q
K
Q
T
REIN
R
E
S
E
F
N
R
L
K
N
L
Q
E
D
V
I
A
Q
L
Q
K
I
E
A
A
Y
S
N
L
L
A
Y
Y
S
H
H-------------------------------------------------
31
PsiBlast_CBE
52.14
39%
-118
- C10 -
3W6N
3
DNM1L_HUMAN
B:
[25-75]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
D
K
R
V
E
-----------
A
E
E
W
G
K
F
L
H
-
T
K
N
---------
K
L
Y
T
D
F
D
E
----
I
R
Q
---------
E
I
E
N
E
--------
T
-------------
E
R
I
S
G
N
N
K
G
V
S
P
E
P
-
I
H
L
K
I
F
S
P
N
V
V
N
L
T
L
--
V
D
L
P
G
M
T
K
V
----
P
V
G
-
D
Q
P
K
D
I
E
L
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
51.64
39%
-129
- C10 -
3W6P
4
DNM1L_HUMAN
B:
[25-75]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
D
K
R
V
E
-----------
A
E
E
W
G
K
F
L
H
-
T
K
N
---------
K
L
Y
T
D
F
D
E
----
I
R
Q
---------
E
I
E
N
E
--------
T
-------------
E
R
I
S
G
N
N
K
G
V
S
P
E
P
-
I
H
L
K
I
F
S
P
N
V
V
N
L
T
L
--
V
D
L
P
G
M
T
K
V
----
P
V
G
-
D
Q
P
K
D
I
E
L
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
50.96
39%
-123
- C10 -
3W6O
2
?
A:
[25-75]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
A
E
E
W
G
-----------
K
F
L
H
T
K
N
K
L
-
Y
T
D
---------
F
D
E
I
R
Q
E
I
----
E
N
E
---------
T
E
R
I
S
--------
G
-------------
N
N
K
G
V
S
P
E
P
I
H
L
K
I
-
F
S
P
N
V
V
N
L
T
L
V
D
L
P
G
--
M
T
K
V
P
V
G
D
Q
----
P
K
D
-
I
E
L
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
A
V
T
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
50.65
39%
-123
- C10 -
3W6O
2
?
B:
[25-75]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
D
K
R
A
E
-----------
E
W
G
K
F
L
H
T
K
-
N
K
L
---------
Y
T
D
F
D
E
I
R
----
Q
E
I
---------
E
N
E
T
E
--------
R
-------------
I
S
G
N
N
K
G
V
S
P
E
P
I
H
-
L
K
I
F
S
P
N
V
V
N
L
T
L
V
D
--
L
P
G
M
T
K
V
P
V
----
G
D
Q
-
P
K
D
I
E
L
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Fugue
50.26
13%
-83
- C4 -
1CR2
3
PRIM_BPT7
A:
[1-277]
-----------------------------------------------M
R
E
R
I
R
E
H
L
S
S
EESV
G
L
L
F
S
GCTG
I
N
D
K
T
L
G
A
R
G
G
E
V
I
M
-
V
T
S
G
S
G
M
G
K
S
T
F
V
R
Q
Q
A
L
Q
-----
W
G
T
A
--
M
G
K
K
V
G
L
A
M
LE
E
S
V
E
E
T
A
E
D
L
I
G
L
H
N
R
V
R
L
R
Q
S
-----------
D
S
L
K
R
E
I
I
E
-
N
G
K
---------
F
D
Q
W
F
D
E
L
----
F
G
N
DT
F
H
L
Y
D
SF
E
A
E
T
D
--------
R
-------------
L
L
A
K
L
A
Y
M
R
S
G
L
G
C
-
D
V
I
I
L
D
H
I
S
I
R
K
M
I
D
--
N
L
M
T
K
L
K
G
F
----
A
K
S
T
G
V
V
L
V
V
I
C
H
L
K
S
G
A
L
R
Q
L
S
D
T
I
I
A
L
E
R
NNL
V
L
V
R
ILKCRFTGDTGIA
G
Y
M
E
Y
NKETG
W
L
E
P
S
SY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
50.24
39%
-118
- C10 -
3W6N
3
DNM1L_HUMAN
A:
[25-75]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
R
G
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
E
E
W
G
K
-----------
F
L
H
T
K
N
K
L
Y
-
T
D
F
---------
D
E
I
R
Q
E
I
E
----
N
E
T
---------
E
R
I
S
G
--------
N
-------------
N
K
G
V
S
P
E
P
I
H
L
K
I
F
-
S
P
N
V
V
N
L
T
L
V
D
L
P
G
M
--
T
K
V
P
V
G
D
Q
P
----
K
D
I
-
E
L
Q
I
R
E
L
I
L
R
F
I
S
N
P
N
S
I
I
L
A
V
T
A
A
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
49.35
39%
-129
- C10 -
4H1V
1
?
A:
[23-73]
------------------------------------------------------------------------------
I
Q
L
P
Q
I
V
--
V
V
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
R
-----
D
L
L
P
RG
T
G
---------
I
V
T
R
R
P
L
I
L
Q
L
V
H
V
S
Q
E
D
K
R
K
T
-----------
T
G
E
E
N
G
V
E
A
-
E
E
W
---------
G
K
F
L
H
T
K
N
----
K
L
Y
---------
T
D
F
D
E
--------
I
-------------
R
Q
E
I
E
N
E
T
E
R
I
S
G
N
-
N
K
G
V
S
P
E
P
I
H
L
K
I
F
S
--
P
N
V
V
N
L
T
L
V
----
D
L
P
-
G
M
T
K
V
P
V
G
D
Q
P
K
D
I
E
L
Q
I
R
E
L
I
L
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Fugue
49.05
11%
-39
- C9 -
1TQ4
2
IIGP1_MOUSE
A:
[14-413]
------------ND
L
P
S
S
F
T
G
Y
F
K
K
FNTGRKIIS
Q
E
I
L
N
L
I
E
L
R
M
R
A
GN
I
Q
L
T
N
S
A
---------------
I
S
D
A
L
K
E
I
D
S
S
V
L
N
V
A
V
T
G
E
T
G
S
G
K
S
S
F
I
N
T
L
R
G
I
-----
G
N
E
E
--
E
G
---------
A
A
K
T
G
V
------------------------------
M
E
R
H
P
Y
-
K
H
P
---------
N
I
P
N
V
V
F
W
----
D
L
P
---------
G
I
G
S
T
--------
N
-------------
F
P
P
D
T
Y
L
E
K
M
K
F
Y
E
Y
D
F
F
I
I
I
S
A
---
T
R
F
K
--
K
N
D
I
D
I
A
K
A
----
I
S
M
-
M
K
K
E
F
Y
F
V
R
T
K
V
D
S
D
I
T
N
E
A
D
G
E
P
Q
T
FD
K
E
K
V
L
Q
D
I
R
L
N
C
V
N
T
F
R
E
N
GIA
E
P
P
I
F
L
L
S
NKNVCHYD
F
P
V
L
M
D
K
L
I
S
D
LPIYK
R
H
N
F
M
V
S
LPNIT
D
S
V
I
E
K
K
R
Q
F
L
K
Q
R
I
W
L
E
G
F
A
A
DLVNIIPSL
T
F
L
L
D
S
D
L
E
T
L
K
K
S
M
K
F
Y
R
T
V
F
GVD
E
T
S
L
Q
R
L
A
RDWEIE
V
D
Q
V
E
A
M
I
KSPAVFKPTD
E
E
T
I
Q
E
R
L
S
R
Y
I
Q
E
F
C
L
A
NGYLLPKNSFLK
E
I
F
Y
L
K
Y
Y
F
L
D
M
V
T
E
D
A
K
T
L
L
K
E
I
C
L
R
N------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Fugue
48.74
15%
-47
- C5 -
1YRB
3
GPN_PYRAB
A:
[1-259]
-------------------------------------------------
M
R
G
S
H
H
H
---------------
H
H
H
-----
G
M
A
S
M
I
V
V
F
V
G
T
A
G
S
G
K
T
T
L
T
G
E
F
G
R
Y
L
EDNY
K
V
A
Y
--
V
N
---------
L
D
T
G
V
K
---
E
L
P
Y
E
P
S
I
D
V
R
E
F
-----------
V
T
V
E
E
I
M
R
E
G
Y
G
P
---------
N
G
A
I
V
E
S
Y
----
D
R
L
---------
M
E
K
F
N
--------
E
-------------
Y
L
N
K
I
L
R
L
E
K
E
N
D
---
Y
V
L
I
D
T
P
G
Q
M
E
T
F
L
F
H
E
F
G
V
R
L
M
E
N
----
L
P
Y
-
P
L
V
V
Y
I
S
D
P
E
I
L
K
K
P
N
D
Y
C
F
V
R
F
F
A
L
L
I
D
L
R
L
GAT
T
I
P
A
L
N
KVDLLS
E
E
E
K
E
R
H
R
K
Y
F
E
D
I
D
Y
L
T
A
R
L
K
L
DPS
M
Q
G
L
M
A
Y
K
M
C
S
M
M
T
E
VLPP
V
R
V
L
Y
L
S
AKTREG
F
E
D
L
E
T
L
A
Y
E
H
Y
C
T
C
G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.51
37%
-81
- C10 -
3ZYC
2
?
A:
[34-95]
-------------------------------------------------------------------------------------
I
A
V
V
G
G
Q
S
A
G
K
S
S
V
L
E
N
F
V
G
R
-----
D
F
L
P
R
G
S
G
---------
I
V
T
R
R
P
L
V
L
Q
L
V
N
A
T
T
E
Y
A
E
F
L
-----------
H
C
K
G
K
K
F
T
D
-
F
E
E
---------
V
R
L
E
I
E
A
E
----
T
D
R
---------
V
T
G
T
N
--------
K
-------------
G
I
S
P
V
P
I
N
L
R
V
Y
S
P
-
H
V
L
N
L
T
L
V
D
L
P
G
M
T
K
--
V
P
V
G
D
Q
P
P
D
----
I
E
F
-
Q
I
R
D
M
L
M
Q
F
V
T
K
E
N
C
L
I
L
A
V
S
P
A
N
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
48.33
37%
-83
- C10 -
3ZYC
2
?
D:
[34-95]
-------------------------------------------------------------------------------------
I
A
V
V
G
G
Q
S
A
G
K
S
S
V
L
E
N
F
V
G
R
-----
D
F
L
P
RG
S
G
---------
I
V
T
R
R
P
L
V
L
Q
L
V
N
A
T
T
E
Y
A
E
F
L
-----------
H
C
K
G
K
K
F
T
D
-
F
E
E
---------
V
R
L
E
I
E
A
E
----
T
D
R
---------
V
T
G
T
N
--------
K
-------------
G
I
S
P
V
P
I
N
L
R
V
Y
S
P
-
H
V
L
N
L
T
L
V
D
L
P
G
M
T
K
--
V
P
V
G
D
Q
P
P
D
----
I
E
F
-
Q
I
R
D
M
L
M
Q
F
V
T
K
E
N
C
L
I
L
A
V
S
P
A
N
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------