@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1001: (2015-12-20 )
MYVEKILQSLQKKYPYQKEFHQAVYEAITSLKPLLDSDKSYEKHAVLERLIEPEREIFFRVCWLDDNHQIQVNRGCRVEFNSAIGPYKGGLRFHPSVNESVIKFLGFEQVLKNSLTTLAMGGAKGGSDFDPKEKSEHEIMRFCQAFMNELYRHIGATTDVPAGDIGVGEREIGYLFGQYKKLVNRFEGVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERNSSLEGKVCSVSGSGNVAIYTIEKLLQIGAKPVTASDSNGMIYDKDGIDLELLKEIKEARRGRIKEYALEKTSAKYTPTENYPKGGNAIWHVPCFAAFPSATENELSVLDAKTLLSNGCKCVAEGANMPSSNEAIELFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVDAKLHHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQGV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....-...190.......200.......210.......220.......230.......240.......250.......260.......270-.---..----......280--.----.---......290.......300.......310.......320.......330.......340.......350.......360........370.......380.......390.......400.......410.......420--........430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
V
E
K
I
L
Q
S
L
Q
K
KY
P
Y
Q
K
E
F
H
Q
A
V
Y
E
A
I
T
S
L
K
P
L
LDSDKS
Y
E
K
H
A
V
L
E
R
L
IEP
E
R
E
I
F
F
R
V
C
W
LDDN
H
Q
I
Q
VNRG
C
R
V
E
FNSAIGPYKGG
L
R
FHPSV
N
E
S
V
I
K
F
L
G
F
E
Q
V
L
K
N
S
L
T
T
L
AMGGAKGGSDFDPKEK
S
E
H
E
I
M
R
F
C
Q
A
F
M
N
E
L
Y
R
HIGATTDVPAGDIGVG
E
R
E
I
G
Y
L
F
G
Q
Y
K
K
L
V
N
R
F
-
E
G
V
LTGKGLTYG
G
S
L
C
R
KEATGY
G
C
V
Y
F
A
E
E
M
L
Q
ERNSSLEG
K
V
C
S
VSGSG
N
V
A
I
Y
T
I
E
K
L
L
QIGAKPVTASDSN
G
M
I
YDKDGI---
D
---
L
E
----
L
L
K
E
I
K
E
A
---
R
----R---G
R
I
K
E
Y
A
LEKTSAKYTPTENYPKGGN
A
I
W
HV
P
C
F
AAFPSATEN
E
L
S
V
L
D
A
K
T
L
L
SNG
C
K
C
V
AEGANMPSS
N
E
A
I
E
L
F
L
-
Q
A
K
I
SYGIGKAANAGG
V
S
VS
G
L
E
M
AQNASMHP
W
S
F
E
V
V
D
A
K
L
H
H
I
M
K
E
I
Y
K
N
V
S
Q
T
A
K
E
F---KDPT
N
F
V
LGA
N
I
A
G
F
R
K
V
A
S
A
M
IAQGV
21
PsiBlast_CBE
98.31
57%
-76
- C8 -
4BHT
6
DHE4_ECOLI
F:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
25
PsiBlast_CBE
98.30
57%
-74
- C8 -
4BHT
4
DHE4_ECOLI
B:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
22
PsiBlast_CBE
98.13
57%
-75
- C8 -
4BHT
10
DHE4_ECOLI
E:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
24
PsiBlast_CBE
97.87
57%
-72
- C8 -
4BHT
9
DHE4_ECOLI
C:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
1
PsiBlast_PDB
97.17
57%
-76
- C8 -
4FCC
-
?
A:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
V
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
K
S
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
V
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
28
PsiBlast_CBE
96.67
57%
-75
- C8 -
3SBO
2
DHE4_ECOLI
D:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
23
PsiBlast_CBE
95.61
57%
-72
- C8 -
4BHT
7
DHE4_ECOLI
D:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
---
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
29
PsiBlast_CBE
95.56
57%
-71
- C8 -
3SBO
2
DHE4_ECOLI
C:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
26
PsiBlast_CBE
95.53
57%
-75
- C8 -
3SBO
1
DHE4_ECOLI
F:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
--
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
----
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
--
P
W
S
L
P
--
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
--------
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
4
PsiBlast_PDB
95.35
55%
-76
- C8 -
2YFH
-
DHE2_CLOSY (first)
A:
[4-446]
-
Y
V
D
R
V
I
A
E
V
E
K
K
Y
A
D
E
P
E
F
V
Q
T
V
E
E
V
L
S
S
L
G
P
V
V
D
A
H
P
E
Y
E
E
V
A
L
L
E
R
M
V
I
P
E
R
V
I
E
F
R
V
P
W
E
D
D
N
G
K
V
H
V
N
T
G
Y
R
V
Q
F
N
G
A
I
G
P
Y
K
G
G
L
R
F
A
P
S
V
N
L
S
I
M
K
F
L
G
F
E
Q
A
F
K
D
S
L
T
T
L
P
M
G
G
A
K
G
G
S
D
F
D
P
N
G
K
S
D
R
E
V
M
R
F
C
Q
A
F
M
T
E
L
Y
R
H
I
G
P
D
I
D
V
P
A
G
D
L
G
V
G
A
R
E
I
G
Y
M
Y
G
Q
Y
R
K
I
V
G
G
F
Y
N
G
V
L
T
G
K
A
R
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
-----------
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
T
D
I
H
D
G
S
A
A
A
A
E
R
Y
---
G
L
G
Y
N
L
V
A
G
A
N
I
V
G
F
Q
K
I
A
D
A
M
M
A
Q
G
I
27
PsiBlast_CBE
95.28
57%
-73
- C8 -
3SBO
2
DHE4_ECOLI
E:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
KEK
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
---
G
R
V
A
D
Y
A
K
E
F
G
L
V
Y
L
E
--------
G
Q
-
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
3
PsiBlast_PDB
94.92
57%
-77
- C8 -
3SBO
1
DHE4_ECOLI
A:
[7-446]
--
L
E
S
F
L
N
H
V
Q
K
R
D
P
N
Q
T
E
F
A
Q
A
V
R
E
V
M
T
T
L
W
P
F
L
E
Q
N
P
K
Y
R
Q
M
S
L
L
E
R
L
V
E
P
E
R
V
I
Q
F
R
V
V
W
V
D
D
R
N
Q
I
Q
V
N
R
A
W
R
V
Q
F
S
S
A
I
G
P
Y
K
G
G
M
R
F
H
P
S
V
N
L
S
I
L
K
F
L
G
F
E
Q
T
F
K
N
A
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
G
E
V
M
R
F
C
Q
A
L
M
T
E
L
Y
R
H
L
G
A
D
T
D
V
P
A
G
D
I
G
V
G
G
R
E
V
G
F
M
A
G
M
M
K
K
L
S
N
N
T
-
A
C
V
F
T
G
K
G
L
S
F
G
G
S
L
I
R
P
E
A
T
G
Y
G
L
V
Y
F
T
E
A
M
L
K
R
H
G
M
G
F
E
G
M
R
V
S
V
S
G
S
G
N
V
A
Q
Y
A
I
E
K
A
M
E
F
G
A
R
V
I
T
A
S
D
S
S
G
T
V
V
D
E
S
G
F
---
T
K
E
K
L
A
----
R
L
I
E
I
K
A
S
---
R
----
D
----
R
V
A
D
Y
A
K
E
F
G
-
V
Y
L
E
--------
G
Q
Q
P
W
S
L
P
V
D
I
A
L
P
C
A
T
Q
N
E
L
D
V
D
A
A
H
Q
L
I
A
N
G
V
K
A
V
A
E
G
A
N
M
P
T
T
I
E
A
T
E
L
F
Q
-
Q
A
G
V
L
F
A
P
G
K
A
A
N
A
G
G
V
A
T
S
G
L
E
M
A
Q
N
A
A
R
L
G
W
K
A
E
K
V
D
A
R
L
H
H
I
M
L
D
I
H
H
A
C
V
E
H
G
G
E
----
G
E
Q
T
N
Y
V
Q
G
A
N
I
A
G
F
V
K
V
A
D
A
M
L
A
Q
G
V
50
HHSearch
94.89
56%
-70
- C8 -
2BMA
-
?
A:
[6-447]
----
N
V
Y
E
R
V
M
K
L
D
P
N
Q
V
E
F
L
Q
A
F
H
E
I
L
Y
S
L
K
P
L
F
M
E
E
P
K
Y
L
--
P
I
I
E
T
L
S
E
P
E
R
A
I
Q
F
R
V
C
W
L
D
D
N
G
V
Q
R
K
N
R
C
F
R
V
Q
Y
N
S
A
L
G
P
Y
K
G
G
L
R
F
H
P
S
V
N
L
S
I
V
K
F
L
G
F
E
Q
I
F
K
N
S
L
T
G
L
S
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
D
N
E
I
L
K
F
C
Q
A
F
M
N
E
L
Y
R
H
I
G
P
C
T
D
V
P
A
G
D
I
G
V
G
G
R
E
I
G
Y
L
Y
G
Q
Y
K
K
I
V
N
S
F
-
N
G
T
L
T
G
K
N
V
K
W
G
G
S
N
L
R
V
E
A
T
G
Y
G
L
V
Y
F
V
L
E
V
L
K
S
L
N
I
P
V
E
K
Q
T
A
V
V
S
G
S
G
N
V
A
L
Y
C
V
Q
K
L
L
H
L
N
V
K
V
L
T
L
S
D
S
N
G
Y
V
Y
E
P
N
G
F
---
T
---
H
E
----
N
L
E
F
L
I
D
L
K
EE
K
----
K
---
G
R
I
K
E
Y
L
N
H
S
------
S
T
A
-
K
Y
F
P
N
E
K
P
W
G
V
P
C
T
L
A
F
P
C
A
T
Q
N
D
V
D
L
D
Q
A
K
L
L
Q
K
N
G
C
I
L
V
G
E
G
A
N
M
P
S
T
V
D
A
I
N
L
F
K
-
S
N
N
I
I
Y
C
P
S
K
A
A
N
A
G
G
V
A
I
S
G
L
E
M
S
Q
N
F
Q
F
S
H
W
T
R
E
T
V
D
E
K
L
K
E
I
M
R
N
I
F
I
A
C
S
E
N
A
-
K
Y
T
KN
K
Y
--
D
L
Q
A
G
A
N
I
A
G
F
L
K
V
A
E
S
Y
I
E
Q
G
C
5
PsiBlast_PDB
94.70
55%
-72
- C8 -
2BMA
-
?
A:
[4-446]
--
M
N
N
V
Y
E
R
V
M
K
L
D
P
N
Q
V
E
F
L
Q
A
F
H
E
I
L
Y
S
L
K
P
L
F
M
E
E
P
K
Y
--
L
P
I
I
E
T
L
S
E
P
E
R
A
I
Q
F
R
V
C
W
L
D
D
N
G
V
Q
R
K
N
R
C
F
R
V
Q
Y
N
S
A
L
G
P
Y
K
G
G
L
R
F
H
P
S
V
N
L
S
I
V
K
F
L
G
F
E
Q
I
F
K
N
S
L
T
G
L
S
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
D
N
E
I
L
K
F
C
Q
A
F
M
N
E
L
Y
R
H
I
G
P
C
T
D
V
P
A
G
D
I
G
V
G
G
R
E
I
G
Y
L
Y
G
Q
Y
K
K
I
V
N
S
F
-
N
G
T
L
T
G
K
N
V
K
W
G
G
S
N
L
R
V
E
A
T
G
Y
G
L
V
Y
F
V
L
E
V
L
K
S
L
N
I
P
V
E
K
Q
T
A
V
V
S
G
S
G
N
V
A
L
Y
C
V
Q
K
L
L
H
L
N
V
K
V
L
T
L
S
D
S
N
G
Y
V
Y
E
P
N
G
F
T
H
E
N
---
L
E
----
F
L
I
D
L
K
E
E
---
K
----
K
---
G
R
I
K
E
Y
L
N
H
S
S
T
A
K
Y
F
P
N
E
-------
K
P
W
G
V
P
C
T
L
A
F
P
C
A
T
Q
N
D
V
D
L
D
Q
A
K
L
L
Q
K
N
G
C
I
L
V
G
E
G
A
N
M
P
S
T
V
D
A
I
N
L
F
K
-
S
N
N
I
I
Y
C
P
S
K
A
A
N
A
G
G
V
A
I
S
G
L
E
M
S
Q
N
F
Q
F
S
H
W
T
R
E
T
V
D
E
K
L
K
E
I
M
R
N
I
F
I
A
C
S
E
N
A
-
K
Y
T
--
K
N
K
Y
D
L
Q
A
G
A
N
I
A
G
F
L
K
V
A
E
S
Y
I
E
Q
G
C
7
PsiBlast_PDB
94.07
50%
-70
- C8 -
1HRD
-
DHE2_CLOSY
A:
[3-447]
-
Y
V
D
R
V
I
A
E
V
E
K
K
Y
A
D
E
P
E
F
V
Q
T
V
E
E
V
L
S
S
L
G
P
V
V
D
A
H
P
E
Y
E
E
V
A
L
L
E
R
M
V
I
P
E
R
V
I
E
F
R
V
P
W
E
D
D
N
G
K
V
H
V
N
T
G
Y
R
V
Q
F
N
G
A
I
G
P
Y
K
G
G
L
R
F
A
P
S
V
N
L
S
I
M
K
F
L
G
F
E
Q
A
F
K
D
S
L
T
T
L
P
M
G
G
A
K
G
G
S
D
F
D
P
N
G
K
S
D
R
E
V
M
R
F
C
Q
A
F
M
T
E
L
Y
R
H
I
G
P
D
I
D
V
P
A
G
D
L
G
V
G
A
R
E
I
G
Y
M
Y
G
Q
Y
R
K
I
V
G
G
F
Y
N
G
V
L
T
G
K
A
R
S
F
G
G
S
L
V
R
P
E
A
T
G
Y
G
S
V
Y
Y
V
E
A
V
M
K
H
E
N
D
T
L
V
G
K
T
V
A
L
A
G
F
G
N
V
A
W
G
A
A
K
K
L
A
E
L
G
A
K
A
V
T
L
S
G
P
D
G
Y
I
Y
D
P
E
G
I
---
T
---
T
E
E
K
I
N
Y
M
L
E
M
R
A
S
---
G
----
R
---
N
K
V
Q
D
Y
A
-
D
K
F
G
V
Q
F
F
P
G
E
K
-
P
W
G
Q
K
V
D
I
I
M
P
C
------
A
T
Q
N
D
V
D
L
E
Q
A
K
K
I
V
A
N
N
V
K
Y
Y
I
E
V
A
N
M
P
T
T
N
E
A
L
R
F
L
M
Q
Q
P
N
M
V
V
A
P
S
K
A
V
N
A
G
G
V
L
V
S
G
F
E
M
S
Q
N
S
E
R
L
S
W
T
A
E
E
V
D
S
K
L
H
Q
V
M
T
D
I
H
D
G
S
A
A
A
A
E
R
Y
---
G
L
G
Y
N
L
V
A
G
A
N
I
V
G
F
Q
K
I
A
D
A
M
M
A
Q
G
I
49
HHSearch
93.33
54%
-73
- C8 -
3R3J
-
?
A:
[69-509]
-
Q
I
E
E
L
R
E
K
V
V
S
K
N
K
N
E
P
E
F
L
Q
A
F
E
E
V
L
S
C
L
K
P
V
F
K
K
D
N
V
Y
I
--
G
V
L
E
N
I
A
E
P
E
R
V
I
Q
F
R
V
P
W
I
N
D
K
G
E
H
K
M
N
R
G
F
R
V
Q
Y
N
S
V
L
G
P
Y
K
G
G
L
R
F
H
P
A
V
N
L
S
V
I
K
F
L
G
F
E
Q
I
F
K
N
S
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
N
E
I
L
K
F
C
Q
S
F
M
T
N
L
F
R
Y
I
G
P
N
T
D
V
P
A
G
D
I
G
V
G
G
R
E
I
G
Y
L
F
G
Q
Y
K
K
L
K
N
S
F
-
E
G
V
L
T
G
K
N
I
K
W
G
G
S
N
I
R
A
E
A
T
G
Y
G
V
V
Y
F
A
E
N
V
L
K
D
L
N
D
N
L
E
N
K
K
C
L
V
S
G
S
G
N
V
A
Q
Y
L
V
E
K
L
I
E
K
G
A
I
V
L
T
M
S
D
S
N
G
Y
I
L
E
P
N
G
F
---
T
---
K
E
----
Q
L
N
Y
I
M
D
I
---
K
----
N
NQR
L
R
L
K
E
Y
L
K
Y
S
------
K
T
A
-
K
Y
F
E
N
Q
K
P
W
N
I
P
C
D
I
A
F
P
C
A
T
Q
N
E
I
N
E
N
D
A
D
L
F
I
Q
N
K
C
K
M
I
V
E
G
A
N
M
P
T
H
I
K
A
L
H
K
L
K
-
Q
N
N
I
I
L
C
P
S
K
A
A
N
A
G
G
V
A
V
S
G
L
E
M
S
Q
N
S
M
R
L
Q
W
T
H
Q
E
T
D
M
K
L
Q
N
I
M
K
S
I
Y
E
Q
C
H
N
T
S
K
I
Y
LN-
E
S
--
D
L
V
A
G
A
N
I
A
G
F
L
K
V
A
D
S
F
L
E
Q
G
G
6
PsiBlast_PDB
92.96
53%
-74
- C8 -
3R3J
-
?
A:
[70-508]
--
I
E
E
L
R
E
K
V
V
S
K
N
K
N
E
P
E
F
L
Q
A
F
E
E
V
L
S
C
L
K
P
V
F
K
K
D
N
V
Y
--
I
G
V
L
E
N
I
A
E
P
E
R
V
I
Q
F
R
V
P
W
I
N
D
K
G
E
H
K
M
N
R
G
F
R
V
Q
Y
N
S
V
L
G
P
Y
K
G
G
L
R
F
H
P
A
V
N
L
S
V
I
K
F
L
G
F
E
Q
I
F
K
N
S
L
T
T
L
P
M
G
G
G
K
G
G
S
D
F
D
P
K
G
K
S
E
N
E
I
L
K
F
C
Q
S
F
M
T
N
L
F
R
Y
I
G
P
N
T
D
V
P
A
G
D
I
G
V
G
G
R
E
I
G
Y
L
F
G
Q
Y
K
K
L
K
N
S
F
-
E
G
V
L
T
G
K
N
I
K
W
G
G
S
N
I
R
A
E
A
T
G
Y
G
V
V
Y
F
A
E
N
V
L
K
D
L
N
D
N
L
E
N
K
K
C
L
V
S
G
S
G
N
V
A
Q
Y
L
V
E
K
L
I
E
K
G
A
I
V
L
T
M
S
D
S
N
G
Y
I
L
E
P
N
G
F
T
K
E
Q
---
L
N
----
Y
I
M
D
I
K
N
N
---
Q
----
R
---
L
R
L
K
E
Y
L
K
Y
S
K
T
A
K
Y
F
E
N
Q
-------
K
P
W
N
I
P
C
D
I
A
F
P
C
A
T
Q
N
E
I
N
E
N
D
A
D
L
F
I
Q
N
K
C
K
M
I
V
E
G
A
N
M
P
T
H
I
K
A
L
H
K
L
K
-
Q
N
N
I
I
L
C
P
S
K
A
A
N
A
G
G
V
A
V
S
G
L
E
M
S
Q
N
S
M
R
L
Q
W
T
H
Q
E
T
D
M
K
L
Q
N
I
M
K
S
I
Y
E
Q
C
H
N
T
S
K
I
Y
---
L
N
E
S
D
L
V
A
G
A
N
I
A
G
F
L
K
V
A
D
S
F
L
E
Q
G
G
8
PsiBlast_PDB
92.66
50%
-67
- C8 -
1BGV
1
DHE2_CLOSY
A:
[3-447]
-
Y
V
D
R
V
I
A
E
V
E
K
K
Y
A
D
E
P
E
F
V
Q
T
V
E
E
V
L
S
S
L
G
P
V
V
D
A
H
P
E
Y
E
E
V
A
L
L
E
R
M
V
I
P
E
R
V
I
E
F
R
V
P
W
E
D
D
N
G
K
V
H
V
N
T
G
Y
R
V
Q
F
N
G
A
I
G
P
Y
K
G
G
L
R
F
A
P
S
V
N
L
S
I
M
K
F
L
G
F
E
Q
A
F
K
D
S
L
T
T
L
P
M
G
G
A
K
G
G
S
D
F
D
P
N
G
K
S
D
R
E
V
M
R
F
C
Q
A
F
M
T
E
L
Y
R
H
I
G
P
D
I
D
V
P
A
G
D
L
G
V
G
A
R
E
I
G
Y
M
Y
G
Q
Y
R
K
I
V
G
G
F
Y
N
G
V
L
T
G
K
A
R
S
F
G
G
S
L
V
R
P
E
A
T
G
Y
G
S
V
Y
Y
V
E
A
V
M
K
H
E
N
D
T
L
V
G
K
T
V
A
L
A
G
F
G
N
V
A
W
G
A
A
K
K
L
A
E
L
G
A
K
A
V
T
L
S
G
P
D
G
Y
I
Y
D
P
E
G
I
---
T
---
T
E
E
K
I
N
Y
M
L
E
M
R
A
S
---
G
----
R
---
N
K
V
Q
D
Y
A
-
D
K
F
G
V
Q
F
F
P
G
E
K
-
P
W
G
Q
K
V
D
I
I
M
P
C
------
A
T
Q
N
D
V
D
L
E
Q
A
K
K
I
V
A
N
N
V
K
Y
Y
I
E
V
A
N
M
P
T
T
N
E
A
L
R
F
L
M
Q
Q
P
N
M
V
V
A
P
S
K
A
V
N
A
G
G
V
L
V
S
G
F
E
M
S
Q
N
S
E
R
L
S
W
T
A
E
E
V
D
S
K
L
H
Q
V
M
T
D
I
H
D
G
S
A
A
A
A
E
R
Y
---
G
L
G
Y
N
L
V
A
G
A
N
I
V
G
F
Q
K
I
A
D
A
M
M
A
Q
G
I
9
PsiBlast_PDB
92.53
49%
-67
- C8 -
1K89
-
DHE2_CLOSY
A:
[3-447]
-
Y
V
D
R
V
I
A
E
V
E
K
K
Y
A
D
E
P
E
F
V
Q
T
V
E
E
V
L
S
S
L
G
P
V
V
D
A
H
P
E
Y
E
E
V
A
L
L
E
R
M
V
I
P
E
R
V
I
E
F
R
V
P
W
E
D
D
N
G
K
V
H
V
N
T
G
Y
R
V
Q
F
N
G
A
I
G
P
Y
L
G
G
L
R
F
A
P
S
V
N
L
S
I
M
K
F
L
G
F
E
Q
A
F
K
D
S
L
T
T
L
P
M
G
G
A
K
G
G
S
D
F
D
P
N
G
K
S
D
R
E
V
M
R
F
C
Q
A
F
M
T
E
L
Y
R
H
I
G
P
D
I
D
V
P
A
G
D
L
G
V
G
A
R
E
L
G
Y
M
Y
G
Q
Y
R
K
I
V
G
G
F
Y
N
G
V
L
T
G
K
A
R
S
F
G
G
S
L
V
R
P
E
A
T
G
Y
G
S
V
Y
Y
V
E
A
V
M
K
H
E
N
D
T
L
V
G
K
T
V
A
L
A
G
F
G
N
V
A
W
G
A
A
K
K
L
A
E
L
G
A
K
A
V
T
L
S
G
P
D
G
Y
I
Y
D
P
E
G
I
---
T
---
T
E
E
K
I
N
Y
M
L
E
M
R
A
S
---
G
----
R
---
N
K
V
Q
D
Y
A
-
D
K
F
G
V
Q
F
F
P
G
E
K
-
P
W
G
Q
K
V
D
I
I
M
P
C
------
A
T
Q
N
D
V
D
L
E
Q
A
K
K
I
V
A
N
N
V
K
Y
Y
I
E
V
A
N
M
P
T
T
N
E
A
L
R
F
L
M
Q
Q
P
N
M
V
V
A
P
S
K
A
V
N
A
G
G
V
L
V
S
G
F
E
M
S
Q
N
S
E
R
L
S
W
T
A
E
E
V
D
S
K
L
H
Q
V
M
T
D
I
H
D
G
S
A
A
A
A
E
R
Y
---
G
L
G
Y
N
L
V
A
G
A
N
I
V
G
F
Q
K
I
A
D
A
M
M
A
Q
G
I
52
HHSearch
91.57
50%
-63
* C8 *
1BGV
1
DHE2_CLOSY
A:
[4-447]
--
V
D
R
V
I
A
E
V
E
K
K
Y
A
D
E
P
E
F
V
Q
T
V
E
E
V
L
S
S
L
G
P
V
V
D
A
H
P
E
Y
E
E
V
A
L
L
E
R
M
V
I
P
E
R
V
I
E
F
R
V
P
W
E
D
D
N
G
K
V
H
V
N
T
G
Y
R
V
Q
F
N
G
A
I
G
P
Y
K
G
G
L
R
F
A
P
S
V
N
L
S
I
M
K
F
L
G
F
E
Q
A
F
K
D
S
L
T
T
L
P
M
G
G
A
K
G
G
S
D
F
D
P
N
G
K
S
D
R
E
V
M
R
F
C
Q
A
F
M
T
E
L
Y
R
H
I
G
P
D
I
D
V
P
A
G
D
L
G
V
G
A
R
E
I
G
Y
M
Y
G
Q
Y
R
K
I
V
G
G
F
Y
N
G
V
L
T
G
K
A
R
S
F
G
G
S
L
V
R
P
E
A
T
G
Y
G
S
V
Y
Y
V
E
A
V
M
K
H
E
N
D
T
L
V
G
K
T
V
A
L
A
G
F
G
N
V
A
W
G
A
A
K
K
L
A
E
L
G
A
K
A
V
T
L
S
G
P
D
G
Y
I
Y
D
P
E
G
I
---
T
---
T
E
----
E
K
I
N
Y
M
L
E
---
M
R
A
S
G
R
---
N
K
V
Q
D
Y
A
D
K
-------
F
G
V
-
Q
F
F
P
G
E
K
P
W
G
Q
K
V
D
I
I
M
P
C
A
T
Q
N
D
V
D
L
E
Q
A
K
K
I
V
A
N
N
V
K
Y
Y
I
E
V
A
N
M
P
T
T
N
E
A
L
R
F
L
M
Q
Q
P
N
M
V
V
A
P
S
K
A
V
N
A
G
G
V
L
V
S
G
F
E
M
S
Q
N
S
E
R
L
S
W
T
A
E
E
V
D
S
K
L
H
Q
V
M
T
D
I
H
D
G
S
A
A
A
A
E
R
Y
---
G
L
G
Y
N
L
V
A
G
A
N
I
V
G
F
Q
K
I
A
D
A
M
M
A
Q
G
I