@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1002: (2015-12-20 )
MFQPLLDAFIESTPIKKKITFKSPPPPLKIAVANWWGGAEEFKKSTLYFILSQRYTITLHQNPNEPSDLVLGSPIGSARKILSYQNTKRVFYTGENEVPNFNLFDYAIGFDELDFRDRYLRMPLYYASLHYKAESVNDTTAPYKLKDNSLYALKKPSHHFKENHPNLCAVVNDESDPLKRGFASFVASNPNAPIRNAFYDALNSIEPVTGGGSVKNTLGYNVKNKSEFLSQYKFNLCFENTQGYGYVTEKIIDAYFSHTIPIYWGSPSVAKDFNPKSFVNVCDFKNFDEAIDYVRYLHTHPNAYLDMLYENPLNTLDGKAYFYQNLSFKKILDFFKTILENDTIYHDNPFIFYRDLNEPLVAIDDLRVNYDDLRVNYDDLRVNYDDLRVNYDRLLQNASPLLELSQNTTFKIYRKAYQKSLPLLRAIRRWVKKLGL
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------........---------.10........20...-..------...30......--.-----.--40-.........50........60........70.---.......80........90........100.......110-------------.......120--.......130.......140...-------....150.......160.......170.......180-----.........190........200.......210.......220-------........230.......-.240.-.---...-------..250......-------.260....--..-.270...--.-----------...280.-----------------......290......---.---300-----........310........320.......330.---------......340....--------...350.......360......-.-------370..------.....380.......390--.......400....-...410.......420.......430....---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------M
F
Q
P
L
L
D
A
---------
F
I
ESTPIKK
K
I
TFKSP-PP------
P
L
K
I
A
V
ANWWG--
G
-----
A
--
E
--
E
F
K
K
S
T
L
Y
F
I
L
SQ
R
Y
T
I
T
L
HQNPNEPSD
L
V
LG---SPI
G
S
A
R
K
I
L
SYQNT
K
R
V
F
Y
TGENEVPNFN
L
F
D
Y
AIGFDE-------------L
D
F
R
D
R
Y
LRM--
P
L
Y
Y
A
S
L
H
Y
K
AESVNDTTA
P
Y
K
L-------KDN
S
L
Y
A
LKKPS
H
H
FKENHP
N
L
C
A
V
VNDES
D
P
L
K
R
-------
G
F
A
S
F
V
ASNP-NA
P
I
R
N
A
F
Y
D
A
L
NSIEPVTGGGSVKNTLGYN--------VK
N
K
S
E
F
L
S
Q
-Y
K
F
N
L
C
F
-ENTQG-Y---
G
Y
V
-------
T
E
K
I
I
D
A
Y
FSH-------
T
I
P
I
YWGS--PS-VAKDF
N
P
--
K
-----------
S
F
V
N
V
CD-----------------FK
N
F
D
E
A
I
D
Y
V
R
Y
L
H
---T---H
P
------
N
A
Y
L
D
M
L
Y
EN-PLNTLDGK
A
Y
F
Y
QNL
S
F
K
K
I
L
D
---------
F
F
K
T
I
LEND
T
I
YH--------DN
P
F
I
F
Y
RDLNEP
L
V
A
I
D
D
L
R
V-
N
-------
Y
D
D
L
R
------
V
N
Y
D
D
L
R
V
N
Y
D
D
L
R
V
N
Y
D
--
R
L
LQNA
S
P
L
L
E
LSQ-N
T
T
F
K
I
Y
R
K
A
Y
Q
KS
L
P
L
L
R
A
I
R
R
W
V
K
KLGL---------------------
3
PsiBlast_PDB
98.93
89%
-115
- C6 -
2NZY
2
?
A:
[1-352]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
---------
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
F
I
F
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.04
89%
-113
- C6 -
2NZX
1
?
A:
[1-349]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
---------
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
-----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.96
89%
-113
- C6 -
2NZW
-
?
A:
[1-349]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
-----------------------------------------------------------------------------------------------------------------------------
15
HHSearch
97.91
90%
-113
- C6 -
2NZW
-
?
A:
[1-349]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
--
A
S
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
E
I
K
--
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
-----------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
97.75
89%
-112
- C6 -
2NZW
2
?
C:
[1-351]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
IK
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
F
I
---------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
97.65
89%
-110
- C6 -
2NZY
3
?
B:
[1-348]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
----------
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_CBE
97.54
89%
-113
- C6 -
2NZX
2
?
C:
[1-350]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
F
----------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
97.32
89%
-110
- C6 -
2NZX
1
?
B:
[1-348]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
----------
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
97.10
89%
-109
- C6 -
2NZY
3
?
C:
[1-351]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
F
I
---------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
96.84
89%
-113
- C6 -
2NZW
1
?
B:
[1-348]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
--
K
S
-
P
P
------
P
L
K
I
A
V
A
N
W
W
G
--
D
-----
E
--
E
I
K
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
----------
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
------------------------------------------------------------------------------------------------------------------------------
36
Fugue
94.85
86%
-104
- C6 -
2NZW
-
?
A:
[1-349]
-------------------------------------------------------------------------------------
M
F
Q
P
L
L
D
A
---------
Y
V
E
S
A
S
I
E
K
M
A
S
K
S
P
P
-
P
L
------
K
I
A
V
A
N
W
W
G
D
E
--
E
-----
I
--
K
--
E
F
K
N
S
V
L
Y
F
I
L
S
Q
R
Y
T
I
T
L
H
Q
N
P
N
E
F
S
D
L
V
F
G
---
N
P
L
G
S
A
R
K
I
L
S
Y
Q
N
A
K
R
V
F
Y
T
G
E
N
E
S
P
N
F
N
L
F
D
Y
A
I
G
F
D
E
-------------
L
D
F
N
D
R
Y
L
R
M
--
P
L
Y
Y
D
R
L
H
H
K
A
E
S
V
N
D
T
T
A
P
Y
K
L
-------
K
D
N
S
L
Y
A
L
K
K
P
S
H
C
F
K
E
K
H
P
N
L
C
A
V
V
N
D
E
S
D
P
L
K
R
-------
G
F
A
S
F
V
A
S
N
P
-
N
A
P
I
R
N
A
F
Y
D
A
L
N
S
I
E
P
V
T
G
G
G
S
V
R
N
T
L
G
Y
N
--------
V
K
N
K
N
E
F
L
S
Q
-
Y
K
F
N
L
C
F
-
E
N
T
Q
G
-
Y
---
G
Y
V
-------
T
E
K
I
I
D
A
Y
F
S
H
-------
T
I
P
I
Y
W
G
S
--
P
S
-
V
A
K
D
F
N
P
--
K
-----------
S
F
V
N
V
H
D
-----------------
F
K
N
F
D
E
A
I
D
Y
I
K
Y
L
H
---
T
---
H
K
------
N
A
Y
L
D
M
L
Y
E
N
-
P
L
N
T
L
D
G
K
A
Y
F
Y
Q
N
L
S
F
K
K
I
L
A
---------
F
F
K
T
I
L
E
N
D
T
I
Y
H
--------
D
N
P
-----------------------------------------------------------------------------------------------------------------------------
17
HHSearch
39.70
9%
-47
- C6 -
3QHP
-
?
A:
[269-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
I
L
K
T
-
C
T
L
Y
V
H
A
---
A
N
V
-----
E
S
E
-------
A
I
A
C
L
E
A
I
S
V
G
-------
I
V
P
V
I
A
N
S
PL
S
A
-
T
R
Q
F
A
L
D
--
E
-----------
R
S
L
F
--
E
-----------------
P
N
N
A
K
D
L
S
A
K
I
D
W
W
L
---
E
---
N
K
------
L
E
R
E
R
M
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
39.53
16%
-6
- C3 -
4BVA
3
CRYM_MOUSE
A:
[24-334]
-------------------------------------------------------------------------------------
K
R
A
P
---
A
---------
F
L
S
A
E
E
V
Q
D
H
L
R
S
S
S
L
L
I
P
------
P
L
E
A
A
L
A
N
F
S
K
--
G
-----
P
--
D
--
G
------
G
V
M
Q
P
V
R
T
V
V
P
V
A
K
H
R
G
F
L
G
V
M
P
A
Y
---
S
A
A
E
D
-------
A
L
T
T
K
L
V
T
F
Y
E
S
H
Q
A
S
V
L
L
F
D
P
-------------------------------------------------------------
S
N
G
S
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
A
T
K
L
L
K
P
P
G
S
-------
D
V
L
C
I
L
G
A
G
V
-
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
F
K
E
V
R
M
W
N
R
-------
T
--------
R
E
N
A
E
K
F
A
S
T
-
V
Q
G
D
V
R
V
-
C
S
S
---------
V
-------
Q
E
A
V
T
G
A
D
V
I
I
-------
T
V
T
M
A
T
E
P
--
I
L
-
F
G
E
W
V
K
P
--
G
-----------
A
H
I
N
A
V
G
-------------------------------
A
---
S
---
R
P
------
D
--------------------------------------------------------------------
W
R
E
L
D
D
E
L
M
R
Q
A
V
L
Y
V
D
S
-------
R
E
A
A
L
------
K
E
S
G
D
V
L
L
S
G
A
D
I
F
A
E
L
G
--
E
V
I
S
G
A
K
P
A
-
H
C
E
K
-
T
T
V
F
K
S
L
G
M
A
V
E
D
L
V
A
A
K
L
V
Y
D
S
W
S
S
G
------------------------
28
HHSearch
39.26
16%
-58
- C6 -
3RHZ
1
?
A:
[192-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
K
E
W
K
Y
D
I
P
L
K
V
Y
T
W
Q
N
V
E
L
P
Q
N
V
H
K
I
N
YRP
D
E
Q
L
L
M
E
M
S
Q
-
G
G
F
G
L
V
W
M
D
D
K
D
K
-
E
Y
Q
S
L
Y
C
-------
S
Y
K
L
G
S
F
L
A
A
G
-------
I
P
V
I
V
Q
E
G
--
I
A
-
N
Q
E
L
I
E
N
N
G
L
-----------
G
W
I
V
---------------------
K
D
V
E
E
A
I
M
K
V
K
N
V
--------
N
E
------
D
E
Y
I
E
L
V
K
N
V
-
R
S
F
N
P
I
L
R
K
G
F
F
T
R
R
L
L
T
E
S
V
F
---------
Q
A
I
C
-------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
37.77
14%
-29
- C5 -
5A5T
-
?
A:
[7-605]
RP
E
N
A
L
K
R
A
N
E
F
L
E
VG
K
K
Q
P
A
L
D
V
L
Y
D
V
M
K
S
KKHR
T
W
Q
K
I
H
E
P
I
M
L
K
Y
L
E
L
C
V
D
L
R
KSH
L
A
K
E
G
L
Y
Q
Y
K
N
I
CQQV
N
I
K
S
L
E
D
V
V
R
A
Y
L
K
L
A
E
E
---------
K
T
E
A
A
K
E
E
S
Q
Q
M
V
L
D
I
-
E
D
LDNIQ
T
P
E
S
V
L
L
S
A
V
S
G
--
E
DTQD
R
T
--
D
--
R
L
L
L
T
P
W
V
K
F
L
W
E
S
Y
R
Q
C
L
D
L
L
R
N
N
S
R
V
E
R
L
Y
---
H
D
I
A
Q
Q
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
K
L
C
D
N
L
R
M
H
L
S
Q
I
Q
R
H
H
N
Q
STAIN
L
N
N
P
E
S
Q
S
M
H
L
E
T
R
L
V
Q
L
D
S
A
I
S
M
E
L
W
Q
E
A
F
K
A
V
E
D
I
H
G
L
F
S
L
S
KKP
P
K
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
W
K
S
G
N
A
L
F
H
A
S
T
L
H
R
L
Y
H
L
S
R
-------
E
M
R
K
N
L
T
Q
D
E
-
M
Q
R
M
S
T
R
V
L
L
A
T
L
S
I
P
I
T
P
E
R
T
D
I
A
R
L
L
-------------
D
M
D
G
I
I
V
E
-
K
Q
R
R
L
A
T
-
L
L
G
L
Q
-
A
---
P
P
T
-------
R
I
G
L
I
N
D
M
V
R
F
-------
N
V
L
Q
Y
--
V
--
V
P
-
E
V
K
D
L
Y
N
--
W
-----------
L
E
V
E
F
N
P
-----------------
L
K
L
C
E
R
V
T
K
V
L
N
W
V
R
---
E
---
Q
P
EKE
P
E
L
Q
Q
Y
V
P
Q
L
Q
S
N
T
I
L
R
L
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
L
T
S
L
V
PFVD
A
F
Q
L
E
R
A
I
V
D
A
A
R
H
C
D
LQVRIDHT
S
R
T
L
S
F
G
S
D
L
N
Y
A
--
T
R
E
D
A
P
I
-
G
PHLQSMP
S
E
Q
I
R
------
N
Q
L
T
A
M
S
S
V
L
A
K
A
L
E
V
I
K
PA
H
I
L
Q
E
K
E
E
Q
H
Q
L
A
V
-
T
A
Y
L
K
N
S
R
K
E
H
Q
R
I
L
A
R
R
Q
T
I
E
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
E
E
L
E
Q
R
E
A
E
L
Q
K
V
R
24
HHSearch
37.21
9%
-47
- C6 -
3OY2
-
?
A:
[287-392]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
C
S
A
E
G
A
V
L
G
-------
K
P
L
I
I
S
A
V
--
G
G
-
A
D
D
Y
F
S
G
--
D
-----------
C
V
Y
K
I
K
P
S
A
W
I
S
VDDRDGI
G
G
I
E
G
I
I
D
V
D
D
L
V
E
A
F
T
F
F
----
K
---
D
E
------
K
N
R
K
E
Y
G
K
R
V
-
Q
D
F
V
K
--
T
K
P
T
W
D
-
D
I
S
S
D
I
I
D
---------
F
F
N
S
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
37.11
9%
-27
- C2 -
2AQJ
3
PRNA_PSEFL
A:
[2-518]
--------------------------------------------------------------------NKPIK
N
I
V
I
V
G
GG
T
A
G
W
M
A
A
S
Y
L
V
R
A
L
QQQ
A
N
I
T
L
I
E
S
A
A
I
P
R
I
G
V
G
E
A
T
-
I
P
------
S
L
Q
K
V
F
F
D
F
L
G
IP
E
-----
R
--
E
--
W
M
P
Q
V
N
G
A
F
K
A
A
I
K
F
V
N
W
R
K
S
P
D
P
S
R
D
D
H
F
Y
H
L
F
G
N
V
P
N
C
D
G
V
P
L
T
H
Y
W
L
R
K
R
E
Q
G
F
Q
Q
P
M
E
Y
A
C
Y
P
Q
P
G
A
L
D
G
K
-------------
L
A
P
C
L
S
D
G
T
R
--
Q
M
S
H
-
A
W
H
F
D
A
H
L
V
A
D
F
L
K
R
W
A
V
-------
E
R
G
V
N
R
V
V
D
E
V
V
D
V
R
L
N
N
R
G
Y
I
S
N
L
L
T
K
E
G
R
T
L
E
A
D
L
F
I
D
CS
G
M
R
G
L
L
I
N
Q
A
L
K
E
P
F
I
D
M
S
D
Y
L
L
C
D
S
A
V
A
S
A
V
P
N
D
D
A
R
D
G
V
E
--------
P
Y
T
S
S
I
A
M
N
S
G
W
T
W
K
I
P
M
-
L
G
R
F
G
-
S
---
G
Y
V
F
S
SHFTS
R
D
Q
A
T
A
D
F
L
K
L
W
GLSDNQ
P
L
N
Q
I
K
F
R
--
V
G
-
R
N
K
R
A
W
V
--
N
-----------
N
C
V
S
I
G
L
-----------------
S
S
C
F
L
E
P
L
E
S
T
G
I
Y
F
---
I
---
Y
A
------
A
L
Y
Q
L
V
K
H
F
P
-
D
T
S
F
D
P
R
L
S
D
A
F
N
A
E
I
V
H
M
F
D
D
---------
C
R
D
F
V
Q
A
H
Y
F
T
T
S
--------
R
D
D
T
P
F
W
L
A
N
R
H
D
L
R
L
S
D
A
I
K
E
-
K
-------
V
Q
R
Y
K
A
GLPLT
T
T
S
F
D
D
S
T
Y
Y
E
T
F
D
Y
E
F
K
--
N
F
W
L
N
G
N
Y
Y
C
I
F
A
G
L
G
M
L
P
D
R
S
L
P
L
L
Q
H
R
P
E
S
I
E
K
A
E
A
M
F
A
S
I
R
R
E
A
E
R
L
R
T
S
LPT
N
Y
D
Y
L
R
S
L
RD
26
HHSearch
36.71
14%
-55
- C6 -
2QZS
1
GLGA_ECOLI
A:
[382-451]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
L
Y
G
L
K
Y
G
-------
T
L
P
L
V
R
R
T
--
G
G
-
L
A
D
T
V
S
D
--
C
S
L
E
N
L
A
D
GVAS
G
F
V
F
--
E
-----------------
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
L
W
S
---
R
P
------
S
L
W
R
F
V
Q
R
Q
A
-
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
36.37
16%
-48
- C6 -
1RZU
1
GLGA1_RHIRD
A:
[381-451]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
L
Y
A
L
R
Y
G
-------
C
I
P
V
V
A
R
T
--
G
G
-
L
A
D
T
V
I
D
--
A
N
H
A
A
L
A
S
KAA-
T
G
V
Q
F
-
S
-----------------
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
---
R
Y
Y
H
D
P
------
K
L
W
T
Q
M
Q
K
L
G
-
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
---------
S
----------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
36.23
21%
-40
- C6 -
1JG7
1
GSTB_BPT4
A:
[244-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
K
N
S
Q
-
A
I
A
A
L
I
I
-
G
D
K
N
Y
N
D
---
N
F
I
-------
T
L
R
V
W
E
T
M
A
S
D
-------
A
V
M
L
I
D
E
E
--
F
D
T
K
H
R
I
I
N
---
D
-----------
A
R
F
Y
V
--------------------
N
N
R
A
E
L
I
D
R
V
N
E
L
K
---
H
---
S
D
------
V
L
R
K
E
M
L
S
I
Q
-
H
D
I
L
N
K
T
R
A
K
K
A
E
W
Q
D
A
F
K
K
A
I
---------
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------