@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1396: (2015-12-23 )
MKCSHCQLEFKESDLFKETINHKELHFCCAGCARVYALLTDLNLESFYDKLNDSTLAPVTPQDSMNILELEQALEENNKGDFILNLLLEKTHCNACLWLNQKVLERLKGVKKVSVNFTTHHLQIVFDKSLNPKEIIQKIESLGYGAKIYNAQNYTLKAQKEQRSYLLTLSVGFFATMNLMFIAIAKYASYGSASYGGANYGGGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVLGMDLSVSFGALSAFVYSLYAMLVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVVENGKQIEKHPKDVAIGSVVWVPSGAKIALDGVLLNSASVDASLISGEFKPLELGVNDPILGGYVNVGVPFSYQVSATFQNSRLSSLLETLKKSFLEKPLIESSANKIADIFSKAVLFLAFVSFLLWQFGLGGNFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFKEALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIHEEFDERLLKSLLKTREHLAHNAILKTLDGDEVDLEKIEFFAHGLKASYQNETLLVGSLKFLNAMGVDLKVKESANIMVGFAKNKTLCALFILEERLKANAKEVIQALQNQGLELEILSGDNESSVKECAKKLGISKYHAHLTPEDKAQIISSYKGVCAMVGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAFHNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSGSSLLVVLNSLRLKRS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....-..-130.......140.......150.......160....-...170.......180.......190.......200.......210.......220.......230-.......240-.......250......---.260....---.---------..-------------270--.........280.......290.......300..------.....310...-....320.......330.......340.......350--..-......360.......370---------........380.......390.......400.......410.......420.......430.......440.-......450.......460.......470.....--..--480...--....490.......500.......510.......520..---.----.----------------------...530.---..---.-----.-----------------..540--....----.....550-..-.---------.-..---.----560.----..----.----..-..570------.---..--....580.....---..590---------------------.---------.......---600.-------...------------------------...610.......620.......630.......640.......650.......-----------------------------660---------------------------------------------------.........670...--...---.---680.........690.......700.-.--.-....710.......720.......730.......740.......750.....------..760-----..-.......770.......780......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKCS
H
C
Q
L
E
FKES
D
L
F
K
E
TIN
H
K
E
L
H
F
C
C
A
G
C
A
R
V
Y
A
L
L
T
DL
N
L
E
S
F
Y
D
KLNDSTLAPVTPQDS
M
N
I
L
E
L
E
Q
A
L
E
ENNK
G
D
F
I
L
N
L
L
L
EKTHC
N
A
C
L
W
L
N
Q
K
V
L
E
R
L
KG
V
K
K
V
S
V
N
F
T
T
H
H
L
Q
I
V
FD-KS-L
N
P
K
E
I
I
Q
K
I
E
SLGYG
A
K
I
YNAQ
N
Y
T
L
K
A
QKEQ
R
S
Y
L
-
L
T
L
S
V
G
F
F
A
T
M
N
L
M
F
I
A
I
A
K
Y
ASYGSASYGGANYG
G
G
M
D
K
L
M
Q
RN
L
D
L
V
S
L
F
L
S
L
L
V
L
V
V
V
G
R
F
F
I
-
K
G
A
F
Y
G
LKNG-VLG
M
D
L
S
V
S
F
G
A
L
S
A
F
---
V
Y
S
L
Y
A
M
L
---V---------SQ-------------E----TYFEAS
S
T
I
L
T
L
VFG
S
K
F
L
E
L
K
A
R
L
FANE
K
C
L
A
L------ESH
E
I
H
S
V
I
V
V-EN
G
K
Q
I
E
KHPKDVAI
G
S
V
V
WVPSG
A
K
I
A
L
D
G
V
L
LN-S--AS-V
D
A
S
L
ISGE
F
K
P
L
ELGVN----------DPILG
G
Y
V
N
VGV
P
F
S
Y
Q
V
S
A
T
F
Q
N
S
R
L
S
S
L
L
E
T
L
K
K
S
F
L
EKP
L
I
E
S
S
A
N
K
I
A
D
I
F
S
K
A
V
L
F
L
A
F
V
S
F
L
L
W
Q
F-GLGG
N
F
E
K
A
L
M
V
C
I
S
V
L
V
ISCP
C
A
F
A
L
A
T
P
I
A
L
V
--
I
G
--
V
FKN
P
L
--
I
V
F
K
E
A
L
F
L
E
T
L
A
K
V
K
K
I
F
IDKTGT
L
T
Q
K
E
V
L
L
K
E
K
I
I
H
---
E
----
E
----------------------
F
D
E
R
L
L
K
---
S
L
---
L
-----
K
-----------------
T
R
E
----
H
L
A
H
----
N
A
I
L
KTLD-GD-E---------
V
-
D
L
---
E
----
K
I
-
E
----
F
F
----
A
----
H
G
-LKASY------Q---N
E
--
T
L
L
V
G
S
L
K
F
L
N
A---MGV
D
----------------------
L
---------
K
V
KESA
N
---
I
M
V
G
-------FAK------------------------N
K
T
L
C
A
L
F
I
L
E
E
R
L
KA
N
A
K
E
V
I
Q
A
L
Q
NQG
L
E
L
E
I
LSGD
N
E
S
S
V
K
E
C
A
K
KLGIS-----------------------------K-----------------------------------------------------YHAHLT
P
E
D
K
A
Q
I
I
S
--SYK---
G
---
V
--
C
A
M
VGDGNN
D
A
L
A
L
K
Q
A
S
V
SLGF-
E
--
K
-
S
ALSKSA
C
D
I
L
L
L
E
E
D
L
S
L
L
E
K
A
F
H
N
A
Q
K
V
Y
Q
V
V
L
Q
N
I
V
L
S
L
I
Y
N
A
I
L
I
P
V
A
------
M
L
G
-------
Y
I
-
N
P
L
I
A
S
LSMSG
S
S
L
L
V
V
L
N
S
L
RLKRS--
1
PsiBlast_PDB
88.54
30%
-99
- C1 -
3J09
-
COPA_ARCFU
A:
[27-726]
--------------------------------------------------------------------------------------------
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
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V
N
L
A
T
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T
A
F
I
R
F
D
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K
R
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I
D
F
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T
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K
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V
I
E
D
L
G
Y
G
--
V
V
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A
-
A
V
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A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
-----
H
F
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L
P
Y
E
----------------
D
F
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Q
L
L
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A
L
P
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F
Y
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S
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K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
---
P
---------
R
E
-------------
Y
----
S
F
Y
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T
S
V
L
L
L
A
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L
L
L
G
R
T
L
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A
R
A
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R
T
G
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A
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L
------
V
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Q
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V
V
V
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--
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S
Y
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D
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S
M
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S
G
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P
V
P
V
L
K
S
K
G
----------
D
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V
F
G
A
T
I
N
N
T
G
V
L
K
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R
A
T
R
V
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G
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T
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L
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L
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---
L
----
N
----------------------
G
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L
---
R
L
---
A
A
I
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R
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R
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----
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----
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A
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K
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A
L
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E
----
K
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----
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----
A
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E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
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Q
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K
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G
M
I
T
G
D
N
W
R
S
A
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A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
---
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
--
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
G
-------
V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--
48
HHSearch
88.08
30%
-98
* C1 *
3J09
-
COPA_ARCFU
A:
[15-728]
--------------------------------------------------------------------------------
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
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A
F
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F
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-
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K
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L
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R
K
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Y
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A
A
F
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L
L
L
F
L
A
H
F
I
S
---------------------
L
P
Y
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D
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I
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L
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Y
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G
A
A
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---
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A
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L
S
T
A
GVL
P
---------
R
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-------------
Y
----
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L
L
L
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V
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K
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K
G
----------
D
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F
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A
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---
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GD
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-
R
----------------------
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I
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---
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V
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L
A
L
-------------
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---------
K
L
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K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
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A
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S
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K
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A
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S
A
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A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
--
K
L
Q
AK-
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S-
G
-
S
D
V
A
V
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S
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D
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V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
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R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
------
A
G
L
L
Y
P
IFGV
V
F
-
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--
68
Fugue
83.81
29%
-99
- C1 -
3RFU
3
?
A:
[74-736]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
Y
L
-
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
G
N
-----------
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
-
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
---
I
Y
S
M
V
A
V
L
---
W
---------
P
G
VFPHAFRSQEGVV
A
----
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
------
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
--
S
F
-
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
--
V
G
--
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
DFV
E
----
D
----------------------
N
A
L
A
L
A
A
---
A
L
---
E
-----
H
-----------------
Q
S
E
----
H
P
L
A
----
N
A
I
V
H
A
A
K
-
E
K
-
G
---------
L
-
S
L
---
G
----
S
V
-
E
----
A
F
----
E
A
P
TG
K
G
-
V
V
G
Q
V
------
D
---
G
H
--
H
V
A
I
G
N
A
R
L
M
Q
E
---
H
G
G
D
N
---------------------
A
---------
P
L
F
E
K
A
D
---
E
L
R
G
K
GA
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
--
E
L
K
---
D
K
GL
I
--
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
T
--
G
-
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
------
A
G
V
LYPLTGL
L
L
-
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
TL
4
PsiBlast_PDB
82.19
29%
-98
- C1 -
4BYG
4
?
A:
[117-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
-
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
---
I
Y
S
M
V
A
V
L
---
W
PGVFPHAFR
S
Q
-------------
E
GVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
KLVPE
S
A
H
R
I
K
------
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
-
G
--
R
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
--
V
G
--
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
I
V
T
---
D
----
D
----------------------
F
V
E
D
N
A
L
---
A
L
---
A
-----
A
-----------------
A
L
E
----
H
Q
S
E
HPLA
N
A
I
V
H
A
A
K
-
E
K
-
G
---------
L
-
S
L
---
G
----
S
V
-
E
----
A
F
EAPT
G
----
K
G
-
V
V
G
Q
V
------
D
---
G
H
--
H
V
A
I
G
N
A
R
L
M
Q
E
---
H
G
G
D
N
A
P
L
F
E
K
A
D
E
------------
L
---------
R
G
K
-
G
A
S
---
V
M
F
M
-------
A
V
D
------------------------
G
K
T
V
-
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
--
E
L
K
---
D
K
G
L
I
--
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
T
--
G
-
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
AGVLYP
L
T
G
L------
L
L
-
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
--
3
PsiBlast_PDB
81.46
29%
-98
- C1 -
4BEV
2
?
A:
[117-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
-
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
---
I
Y
S
M
V
A
V
L
---
W
PGVFPHAFR
S
Q
-------------
E
GVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
LKLVPE
S
A
H
R
I
K
------
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
-
G
--
R
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
--
V
G
--
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
I
V
T
---
D
----
D
----------------------
F
V
E
D
N
A
L
---
A
L
---
A
-----
A
-----------------
A
L
E
----
H
Q
S
E
HPLA
N
A
I
V
H
A
A
K
-
E
K
-
G
---------
L
-
S
L
---
G
----
S
V
-
E
----
A
F
EAPT
G
----
K
G
-
V
V
G
Q
V
------
D
---
G
H
--
H
V
A
I
G
N
A
R
L
M
Q
E
---
H
G
G
D
N
A
P
L
F
E
K
A
D
E
------------
L
---------
R
G
K
-
G
A
S
---
V
M
F
M
-------
A
V
D
------------------------
G
K
T
V
-
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
--
E
L
K
---
D
K
G
L
I
--
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
T
--
G
-
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
AGVLYP
L
T
G
L------
L
L
-
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
--
69
Fugue
80.32
25%
-98
- C1 -
4UMW
2
?
A:
[124-730]
------------------------------------------------------------------------
R
L
K
E
N
-------------------------------------------------------
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
-------
H
P
F
G
Q
L
A
F
I
-
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
--------------------------
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
----------------------
G
A
T
A
E
A
---
A
M
V
L
L
L
F
L
---
I
---------
G
E
-------------
R
----
L
E
G
W
A
A
S
R
V
------
S
A
L
M
A
L
K
P
E
----------------------
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
--
A
S
-
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
-
L
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
--
S
G
L
A
A
A
A
R
R
G
--
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
---
T
----
G
----------------------
I
S
E
S
E
L
L
---
T
L
---
A
-----
A
-----------------
A
V
E
QGAT
H
P
L
A
----
Q
A
I
V
R
E
A
Q
-
V
A
-
E
---------
L
-
A
I
---
P
TAES
Q
R
-
A
----
L
V
----
G
----
S
G
-
I
E
A
Q
V
------
N
---
G
E
--
R
V
L
I
C
A
A
G
K
H
P
A
---
D
A
F
A
----------------------
G
---------
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
-------
V
V
R
------------------------
N
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
--
K
L
N
---
Q
---
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
-
G
--
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
------
L
L
G
-------
M
T
-
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---
2
PsiBlast_PDB
79.77
29%
-96
- C1 -
3RFU
3
?
A:
[117-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
-
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
---
I
Y
S
M
V
A
V
L
---
W
PGVFPHAFR
S
Q
-------------
E
GVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
KLVPE
S
A
H
R
I
K
------
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
-
G
--
R
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
--
V
G
--
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
I
V
T
---
D
----
D
----------------------
F
V
E
D
N
A
L
---
A
L
---
A
-----
A
-----------------
A
L
E
----
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
A
K
-
E
K
-
G
---------
L
-
S
L
---
G
----
S
V
-
E
----
A
F
E
A
P
T
G
----
K
G
-
V
V
G
Q
V
------
D
---
G
H
--
H
V
A
I
G
N
A
R
L
M
Q
E
---
H
G
G
D
N
A
P
L
F
E
K
A
D
E
------------
L
---------
R
G
K
-
G
A
S
---
V
M
F
M
-------
A
V
D
------------------------
G
K
T
V
-
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
--
E
L
K
---
D
K
GL
I
--
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
T
--
G
-
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYP
L
T
G
L------
L
L
-
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
--
7
PsiBlast_PDB
79.58
23%
-98
- C1 -
4UMW
2
?
A:
[124-730]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
-
I
T
L
---------
I
V
M
M
A
I
----
S
W
G
L
E
Q
F
---
N
H
P
F
G
Q
--------------
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
---
F
I
G
A
T
A
--------------------------------------
E
A
A
M
V
L
L
L
F
L
I
G
E
R
-
L
E
G
W
A
A
S
R
----
V
S
A
L
------
M
A
L
K
P
E
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
-
P
F
-
A
S
-
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
-
L
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
--
A
A
A
R
R
G
--
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
---
T
----
G
----------------------
I
S
E
S
E
L
L
---
T
L
---
A
-----
A
-----------------
A
V
E
QGAT
H
P
L
A
----
Q
A
I
V
R
E
A
Q
-
V
A
-
E
---------
L
-
A
I
---
P
----
T
A
-
E
SQRA
L
V
----
G
----
S
G
-
I
E
A
Q
V
------
N
---
G
E
--
R
V
L
I
C
A
A
G
K
H
P
A
DAF
A
G
L
I
----------------------
N
---------
E
L
E
S
A
G
Q
---
T
V
V
L
-------
V
V
R
------------------------
N
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
---
A
---
P
--
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
--
G
-
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
------
L
L
G
-------
M
T
-
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---
49
HHSearch
78.88
31%
-96
- C1 -
3J08
-
COPA_ARCFU
A:
[96-727]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
M
K
-
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
S
---------------------
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
-
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
---
L
A
S
V
L
S
T
A
GVL
P
---------
R
E
-------------
Y
----
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
------
V
G
L
Q
A
K
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
--
S
Y
-
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
-
I
A
H
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
--
V
G
M
G
K
G
A
E
L
G
--
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
---
N
GD
E
-
R
----------------------
E
L
L
R
L
A
A
---
I
A
---
E
-----
R
-----------------
R
S
E
----
H
P
I
A
----
E
A
I
V
K
K
A
L
-
E
H
-
G
I
E
L
------
G
-
E
P
---
E
----
K
V
E
V
----
I
A
----
G
----
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
V
S
N
E
V
E
L
A
L
-------------
E
---------
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
--
K
L
Q
AK-
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S-
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
------
A
G
L
L
Y
P
IFGV
V
F
-
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--
5
PsiBlast_PDB
75.51
30%
-92
- C1 -
3J08
-
COPA_ARCFU
A:
[125-726]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
-
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
---
P
---------
R
E
-------------
Y
----
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
------
V
G
L
Q
A
K
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
-
G
--
E
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
-
I
A
H
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
--
V
G
--
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
-
L
V
P
---
L
----
N
----------------------
G
D
E
R
E
L
L
---
R
L
---
A
A
I
A
E
-
R
-----------------
R
S
E
----
H
P
I
A
----
E
A
I
V
K
K
A
L
-
E
H
-
G
---------
I
-
E
L
G
EP
E
----
K
V
-
E
----
V
I
----
A
G---
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
---
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
--
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
G
-------
V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
--
6
PsiBlast_PDB
73.80
23%
-91
- C1 -
4UMV
2
?
A:
[126-730]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
N
L
P
L
-
I
T
L
---------
I
V
M
M
A
I
----
S
W
G
L
E
Q
F
---
N
H
P
F
G
Q
--------------
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
---
F
I
G
A
T
A
--------------------------------------
E
A
A
M
V
L
L
L
F
L
I
G
E
R
-
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
------
M
A
L
K
P
E
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
-
P
F
-
A
S
-
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
-
L
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
--
A
A
A
R
R
G
--
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
---
T
----
G
----------------------
I
S
E
S
E
L
L
---
T
L
---
A
-----
A
-----------------
A
V
E
QGAT
H
P
L
A
----
Q
A
I
V
R
E
A
Q
-
V
A
-
E
---------
L
-
A
I
---
P
----
T
A
-
E
S
QRA
L
V
----
G
----
S
G
-
I
E
A
Q
V
------
N
---
G
E
--
R
V
L
I
C
A
A
G
K
H
P
A
DAF
A
G
L
I
----------------------
N
---------
E
L
E
S
A
G
Q
---
T
V
V
L
-------
V
V
R
------------------------
N
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
---
A
---
P
--
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
--
G
-
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
------
L
L
G
-------
M
T
-
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---
50
HHSearch
59.61
18%
-73
- C1 -
2ZXE
5
?
A:
[138-794]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
------
K
N
M
V
P
Q
Q
A
L
V
I
-
R
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G-
C
K
-
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
-
L
G
-
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
--
L
T
A
K
R
M
A
R
K
N
--
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
---
N
----
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
A
L
S
R
I
A
---
A
L
---
C
-----
N
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
----
D
A
S
E
----
S
A
L
L
K
C
I
E
-
L
C
C
G
S
V
Q
G
M
R
D
R
N
P
-
K
I
---
V
----
E
I
P
F
----
N
S
----
T
----
N
K
Y
Q
L
S
I
H
ENEKSS
E
---
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
---
R
C
S
T
ILLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
L
---------
E
L
G
G
L
G
E
---
R
V
L
G
-------
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
-----------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
--
G
C
Q
R
Q
G
A
---
I
--
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
-
G
IS
G
-
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
------
L
V
F
-------
I
I
-
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
--
16
PsiBlast_PDB
56.62
28%
-78
- C1 -
3A1D
2
?
A:
[18-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
-
L
V
P
---
L
----
N
----------------------
G
D
E
R
E
L
L
---
R
L
---
A
A
I
A
E
-
R
-----------------
R
S
E
----
H
P
I
A
----
E
A
I
V
K
K
A
L
-
E
H
-
G
---------
I
-
E
L
G
E
P
E
----
K
V
-
E
----
V
I
----
A
G---
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
---
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
--
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
----------------------------------------------------------------------
9
PsiBlast_PDB
56.17
26%
-72
- C1 -
3SKY
2
A:
[7-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
---
N
----
H
----------------------
S
E
D
E
L
L
Q
I
A
A
S
L
---
E
-----
A
-----------------
R
S
E
----
H
P
I
A
----
A
A
I
V
E
E
A
E
-
K
R
-
G
---------
F
-
G
L
---
T
----
E
V
-
E
----
E
F
R
A
I
P
G
----
K
G
-
V
E
G
I
V
------
N
---
G
R
--
R
Y
M
V
V
S
P
G
Y
I
R
E
---
L
G
I
K
----------------------
T
D
E
S
V
E
----
K
L
K
Q
Q
G
K
---
T
V
V
F
-------
I
L
K
------------------------
N
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
---
Y
---
V
--
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
A
--
G
-
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-------------------------------------------------------------------
8
PsiBlast_PDB
56.08
26%
-73
- C1 -
3SKX
2
A:
[7-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
---
N
----
H
----------------------
S
E
D
E
L
L
Q
I
A
A
S
L
---
E
-----
A
-----------------
R
S
E
----
H
P
I
A
----
A
A
I
V
E
E
A
E
-
K
R
-
G
---------
F
-
G
L
---
T
----
E
V
-
E
----
E
F
R
A
I
P
G
----
K
G
-
V
E
G
I
V
------
N
---
G
R
--
R
Y
M
V
V
S
P
G
Y
I
R
E
---
L
G
I
K
----------------------
T
D
E
S
V
E
----
K
L
K
Q
Q
G
K
---
T
V
V
F
-------
I
L
K
------------------------
N
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
---
Y
---
V
--
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
A
--
G
-
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-------------------------------------------------------------------
15
PsiBlast_PDB
55.72
28%
-76
- C1 -
3A1C
2
?
A:
[18-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
-
L
V
P
---
L
----
N
----------------------
G
D
E
R
E
L
L
---
R
L
---
A
A
I
A
E
-
R
-----------------
R
S
E
----
H
P
I
A
----
E
A
I
V
K
K
A
L
-
E
H
-
G
---------
I
-
E
L
G
E
P
E
----
K
V
-
E
----
V
I
----
A
G---
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
---
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
--
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-----------------------------------------------------------------------
17
PsiBlast_PDB
54.38
28%
-75
- C1 -
3A1E
2
COPA_ARCFU
A:
[18-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
-
L
V
P
---
L
----
N
----------------------
G
D
E
R
E
L
L
---
R
L
---
A
A
I
A
E
R
R
-----------------
S
E
Q
----
P
I
A
E
----
A
I
V
K
K
A
L
E
H
G
I
-
E
---------
L
G
E
P
---
E
----
K
V
-
E
----
V
I
----
A
G---
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
----------------------
V
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
---
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
S
--
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
----------------------------------------------------------------------
56
HHSearch
54.13
25%
-73
- C1 -
3SKX
2
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
---
N
HS
E
-
D
----------------------
E
L
L
Q
I
A
A
---
S
L
---
E
-----
A
-----------------
R
S
E
----
H
P
I
A
----
A
A
I
V
E
E
A
E
-
K
R
-
G
F
G
L
------
T
-
E
V
---
E
----
E
F
R
A
----
I
P
----
G
----
K
G
-
V
E
G
I
V
------
N
---
G
R
--
R
Y
M
V
V
S
P
G
Y
I
R
E
---
L
G
I
K
T
D
E
S
V
-----------------
E
---------
K
L
K
Q
Q
G
K
---
T
V
V
F
-------
I
L
K
------------------------
N
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
--
E
V
Q
QK-
Y
---
V
--
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
-
G
A-
G
-
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-------------------------------------------------------------------
51
HHSearch
53.80
19%
-77
- C1 -
1MHS
-
PMA1_NEUCR
A:
[152-702]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
N
A
V
V
G
F
V
Q
E
F
Q
A
G
S
I
---
V
D
E
L
------
K
K
T
L
A
L
K
A
V
V
L
-
R
D
G
T
L
K
E
I
E
A
P
E
V
V
P
G
D
I
L
Q
V
E
E
G
T
I
I
P
A
D
G
R
I
V
T
D
D
A
F
L
Q
-
V
D
Q
S
A
L
T
G
E
S
L
A
V
D
K
H
K
G
----------
D
Q
V
F
A
S
S
A
V
K
R
G
E
A
F
V
V
I
T
A
T
G
D
N
T
F
V
G
R
A
A
A
L
V
N
A
A
S
G
G
S
G
H
F
T
E
V
L
N
G
I
G
T
I
L
L
I
L
V
I
F
T
L
L
I
V
W
V
S
S
F
Y
-
R
S
-
N
P
I
V
Q
I
L
E
F
T
L
A
I
T
I
I
G
V
P
V
G
L
P
A
V
V
T
T
T
M
A
--
V
G
A
A
Y
L
A
K
K
K
--
A
I
V
Q
K
L
S
A
I
E
S
L
A
G
V
E
I
L
C
S
D
K
T
G
T
L
T
K
N
K
L
S
L
H
D
P
Y
T
V
---
A
GVDP
E
----------------------
D
L
M
L
T
A
C
---
L
A
ASR
K
-----
K
-----------------
K
G
I
----
D
A
I
D
----
K
A
F
L
K
S
L
K
-
Y
Y
-
P
RAKSVLS
K
-
Y
-
K
V
L
Q
F
H
----
P
F
-
D
----
P
V
----
S
----
K
K
-
V
V
A
V
V
------
E
S
PQ
G
E
R
I
T
C
V
K
G
A
P
L
F
V
L
K
---
T
V
E
E
DHPIP
E
E
V
D
Q
A
Y
K
N
K
V
------
A
---------
E
F
A
T
R
G
F
---
R
S
L
G
-------
V
A
R
K
RGEG-------------------
S
W
E
I
L
G
I
M
P
C
M
D
P
P
R
H
D
T
Y
K
T
V
C
E
A
K
T
L
G
L
S
I
K
M
L
T
G
D
A
V
G
I
A
R
E
T
S
R
Q
L
G
L
G
TNIYNAERLGLGGGGDMPGSEV
Y
D
F
V
E
AA
D
-----------------------------------------------------
G
F
A
E
V
F
P
Q
H
K
Y
N
V
V
E
--
I
L
Q
Q
R
G
Y
---
L
--
V
A
M
T
G
D
G
V
N
D
A
P
S
L
K
K
A
D
T
G
I
A
V
-
E
G-
S
-
S
D
A
A
R
S
A
A
D
I
V
F
L
A
P
G
L
G
A
I
I
D
A
L
K
T
S
R
Q
I
F
H
R
M
Y
A
Y
V
V
Y
R
I
A
L
S
I
H
L
E
I
F
L
------
G
L
W
-------
I
A
-
I
L
N
R
S
L
N
I
E
L
V
V
F
I
A
I
F
A
D
V
A
T
L
A
I
A
--
55
HHSearch
53.75
28%
-69
- C1 -
3A1C
2
?
A:
[14-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
--
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
---
N
GD
E
-
R
----------------------
E
L
L
R
L
A
A
---
I
A
---
E
-----
R
-----------------
R
S
E
----
H
P
I
A
----
E
A
I
V
K
K
A
L
-
E
H
-
G
I
E
L
------
G
-
E
P
---
E
----
K
V
E
V
----
I
A
----
G
----
E
G
-
V
V
A
-------------
D
--
G
I
L
V
G
N
K
R
L
M
E
D
---
F
G
V
A
V
S
N
E
V
E
L
A
L
-------------
E
---------
K
L
E
R
E
A
K
---
T
A
V
I
-------
V
A
R
------------------------
N
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
--
K
L
Q
AK-
E
---
V
--
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S-
G
-
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-----------------------------------------------------------------------