@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0036: (2016-03-11 )
MNKKRDFIDTKDFSKEEILFMIEIGRKMKESIKNGHYPQLLKHKTLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGHESVGDTAKVLSRLVDILMARVERHQTVVELANTAAIPVINGMSDYNHPTQELGDAITMFEHLPKGKKIEDCKIVFVGDATQVCASTMFMATKLGMDFVQFGPKGFQLREEHLKVAEENCEVSGGSYLITEDVDIALKDADFIYTDVWYGLYEAELSEEERMKTFYPKYQVNKELISKAAPHVKFMHCLPATRGEEVTDEVLDAPYSVVIDEAENRLTAMRALLVYFMNPYVKEAGFAVAEKYDAELELLLRNGAGL
Atome Classification :
(44 SA)
.........10........20........30...-.....40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.-.-.-....170......-.180.......190---........200.......210.......220.......230.......240.......250.......260...-.....270...-----------------..------------------..280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKKRDFIDTKDF
S
K
E
E
I
L
F
M
I
E
I
G
R
K
M
K
E
S
IKN-GH
Y
P
Q
L
L
K
HK
T
L
G
M
I
F
EQSST
R
T
R
V
S
F
E
T
A
M
T
QLGGH
A
Q
YLAP
G
Q
I
Q
LGGHESVG
D
T
A
K
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
Q
T
V
V
E
L
ANTAAI
P
V
INGMSDYN
H
P
T
Q
E
L
G
D
A
I
T
M
F
E
HLPKGKKI
E
D
C
K
I
V
F
VG
D
-
A
-
T
-
Q
V
C
A
S
T
M
F
M
A
T
K
L-G
M
D
F
V
Q
FGPKG
F
Q
----
L
R
E
E
H
L
K
V
A
E
ENCEVSGG
S
Y
L
I
TED
V
D
I
A
LKDA
D
F
I
Y
T
D
V
W
Y
G
L
Y
E
A
EL
S
E
E
E
R
M
K
T
FYPKYQV
N
K
E
L
I
S
-KAA-PH
V
K
F
M
H
CLPA-----------------TR------------------G
E
E
V
T
D
E
V
LDAP
Y
S
V
V
IDEAE
N
R
L
T
A
M
R
A
L
L
V
Y
F
M
N
P
Y
V
K
EAG
F
A
V
A
E
K
Y
D
A
E
L
E
L
L
LRNGAGL
4
PsiBlast_PDB
95.89
70%
-108
- C7 -
4A8T
3
PTC_ENTFA
A:
[24-334]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
--------------------------
1
PsiBlast_PDB
95.83
67%
-106
- C7 -
4A8H
6
PTC_ENTFA
A:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
26
PsiBlast_CBE
95.62
67%
-106
- C7 -
4A8H
6
PTC_ENTFA
B:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
41
PsiBlast_CBE
95.55
67%
-110
- C7 -
4AM8
5
PTC_ENTFA
C:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
----
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
2
PsiBlast_PDB
95.35
67%
-107
- C7 -
4A8P
3
PTC_ENTFA
A:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
23
PsiBlast_CBE
95.32
67%
-108
- C7 -
4A8P
2
PTC_ENTFA
D:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
---
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
--
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
40
PsiBlast_CBE
95.31
67%
-107
- C7 -
4AM8
4
PTC_ENTFA
D:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
5
PsiBlast_PDB
95.08
67%
-106
- C7 -
4AM8
5
PTC_ENTFA
A:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
22
PsiBlast_CBE
95.05
67%
-109
- C7 -
4A8P
2
PTC_ENTFA
E:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
----
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
25
PsiBlast_CBE
94.78
67%
-109
- C7 -
4A8P
4
PTC_ENTFA
B:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
-
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
42
PsiBlast_CBE
94.72
67%
-108
- C7 -
4AM8
5
PTC_ENTFA
B:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
Q
I
Q
L
G
-
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
21
PsiBlast_CBE
94.57
67%
-111
- C7 -
4A8P
2
PTC_ENTFA
F:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
---------
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
-------
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
24
PsiBlast_CBE
94.34
67%
-107
- C7 -
4A8P
4
PTC_ENTFA
C:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
39
PsiBlast_CBE
94.33
67%
-108
- C7 -
4AM8
3
PTC_ENTFA
E:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
-----
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
38
PsiBlast_CBE
94.16
67%
-106
- C7 -
4AM8
4
PTC_ENTFA
F:
[2-330]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
-----
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
34
PsiBlast_CBE
93.13
67%
-104
- C7 -
3TXX
3
PTC_ENTFA
E:
[22-350]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
---------
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
31
PsiBlast_CBE
92.70
67%
-102
- C7 -
3TXX
3
PTC_ENTFA
H:
[22-350]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
-----
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
36
PsiBlast_CBE
92.43
67%
-102
- C7 -
3TXX
2
PTC_ENTFA
C:
[22-350]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
37
PsiBlast_CBE
92.36
67%
-102
- C7 -
3TXX
3
PTC_ENTFA
B:
[22-350]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
29
PsiBlast_CBE
92.07
67%
-99
- C7 -
3TXX
2
PTC_ENTFA
J:
[22-350]
---
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
N
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
P
E
G
K
K
L
E
D
C
K
V
V
F
V
G
D
-
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
-
G
M
N
F
V
H
F
G
P
E
G
F
Q
----
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
A
G
-
A
N
C
K
F
M
H
C
L
P
A
-----------------
T
R
------------------
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
N
P
Y
D
L
I
K
Q
A
E
A
K
K
E
L
--------
52
PsiBlast_CBE
83.02
37%
-102
- C7 -
4JFR
3
OTC_VIBVU
B:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
14
PsiBlast_PDB
82.67
37%
-101
- C7 -
4JHX
3
OTC_VIBVU
A:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
47
PsiBlast_CBE
82.61
37%
-95
- C7 -
4JQO
6
OTC_VIBVU
C:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
54
PsiBlast_CBE
82.47
37%
-97
- C7 -
4H31
12
OTC_VIBVU
B:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
15
PsiBlast_PDB
82.40
37%
-98
- C7 -
4JQO
8
OTC_VIBVU
A:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
12
PsiBlast_PDB
82.11
37%
-99
- C7 -
4H31
14
OTC_VIBVU
A:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
48
PsiBlast_CBE
82.02
37%
-97
- C7 -
4JQO
6
OTC_VIBVU
B:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
13
PsiBlast_PDB
81.71
37%
-100
- C7 -
4JFR
2
OTC_VIBVU
A:
[30-353]
--
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
-
S
Q
G
K
A
L
A
D
I
Q
F
A
Y
L
G
D
-
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
-
G
M
D
I
R
L
V
G
P
Q
A
Y
W
----
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
S
P
E
A
W
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
FHNDET
T
I
G
K
Q
V
A
D
K
F
G
M
K
------------------
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
59
PsiBlast_CBE
81.46
38%
-99
- C7 -
1C9Y
2
OTC_HUMAN
A:
[5-312]
--
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
-
E
K
K
K
R
L
Q
A
F
Q
-
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
------------------
R
K
------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
--------------------------
58
PsiBlast_CBE
81.46
38%
-97
- C7 -
1EP9
1
OTC_HUMAN
A:
[5-312]
--
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
-
E
K
K
K
R
L
Q
A
F
Q
-
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
------------------
R
K
------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
--------------------------
43
PsiBlast_CBE
80.52
43%
-99
- C7 -
4NF2
4
OTC_BACAN
C:
[36-330]
----
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
-
K
Q
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
N
T
F
K
G
I
---
K
L
A
Y
V
G
D
-
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
-
G
M
H
M
T
V
A
T
P
V
G
Y
R
----
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
A
K
-
Q
T
Y
H
F
L
H
C
L
P
A
-----------------
H
R
------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
--------------------------------
57
PsiBlast_CBE
80.44
38%
-97
- C7 -
1FVO
1
OTC_HUMAN
A:
[5-312]
--
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
-
E
K
K
K
R
L
Q
A
F
Q
-
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
------------------
R
K
------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
--------------------------
56
PsiBlast_CBE
80.39
38%
-100
- C7 -
1FVO
1
OTC_HUMAN
B:
[5-312]
--
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
-
E
K
K
K
R
L
Q
A
F
Q
-
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
------------------
R
K
------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
--------------------------
20
PsiBlast_PDB
80.36
38%
-98
- C7 -
1OTH
1
OTC_HUMAN
A:
[5-312]
--
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
S
L
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
-
E
K
K
K
R
L
Q
A
F
Q
-
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
------------------
R
K
------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
--------------------------
9
PsiBlast_PDB
80.28
43%
-98
- C7 -
4NF2
5
OTC_BACAN
A:
[36-330]
----
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
-
K
Q
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
N
T
F
K
G
I
---
K
L
A
Y
V
G
D
-
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
-
G
M
H
M
T
V
A
T
P
V
G
Y
R
----
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
A
K
-
Q
T
Y
H
F
L
H
C
L
P
A
-----------------
H
R
------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
--------------------------------
44
PsiBlast_CBE
79.66
43%
-98
- C7 -
4NF2
5
OTC_BACAN
B:
[36-330]
----
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
---
K
N
-
K
Q
E
P
-
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
N
T
F
K
G
I
---
K
L
A
Y
V
G
D
-
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
-
G
M
H
M
T
V
A
T
P
V
G
Y
R
----
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
--
G
Q
E
G
E
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
-
H
A
K
-
Q
T
Y
H
F
L
H
C
L
P
A
-----------------
H
R
------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
--------------------------------
113
HHSearch
79.05
39%
-92
- C7 -
1OTH
1
OTC_HUMAN
A:
[4-316]
-
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
S
S
--
L
-
K
G
L
T
L
S
W
I
G
D
-
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
-
G
M
H
L
Q
A
A
T
P
K
G
Y
E
----
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
E
E
E
-
K
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
A
A
-
S
D
W
T
F
L
H
C
L
P
R
-----------------
K
P
-------------------
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
----------------------
62
PsiBlast_CBE
77.68
37%
-96
- C7 -
1DUV
2
OTC1_ECOLI
H:
[6-328]
----
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
-
G
K
A
F
N
E
M
T
L
V
Y
A
G
D
-
A
-
R
-
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
PEAA
L
V
T
E
C
R
A
L
A
Q
Q
N
----
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
-
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
-
P
E
V
K
F
L
H
C
L
P
A
-----------------
F
H
DDQTTLGKKMAEEFGLHG
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
63
PsiBlast_CBE
76.92
37%
-95
- C7 -
1DUV
3
OTC1_ECOLI
G:
[6-328]
----
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
-
G
K
A
F
N
E
M
T
L
V
Y
A
G
D
-
A
-
R
-
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
PEAA
L
V
T
E
C
R
A
L
A
Q
Q
N
----
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
-
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
-
P
E
V
K
F
L
H
C
L
P
A
-----------------
F
H
DDQTTLGKKMAEEFGLHG
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
61
PsiBlast_CBE
76.64
37%
-95
- C7 -
1DUV
2
OTC1_ECOLI
I:
[6-328]
----
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
G
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
-
G
K
A
F
N
E
M
T
L
V
Y
A
G
D
-
A
-
R
-
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
PEAA
L
V
T
E
C
R
A
L
A
Q
Q
N
----
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
E
K
W
A
E
R
I
-
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
G
N
-
P
E
V
K
F
L
H
C
L
P
A
-----------------
F
H
DDQTTLGKKMAEEFGLHG
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
--------------------------------
85
PsiBlast_CBE
75.27
36%
-97
- C7 -
2I6U
5
OTC_MYCTU
C:
[3-304]
----
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
--
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
--
K
G
-
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
-
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
-
G
I
H
V
T
V
A
A
P
E
G
F
L
----
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
A
D
-
S
D
A
I
V
L
H
C
L
P
A
-----------------
H
R
------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
-----------------------------
86
PsiBlast_CBE
74.69
36%
-95
- C7 -
2I6U
5
OTC_MYCTU
B:
[3-304]
----
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
--
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
--
K
G
-
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
-
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
-
G
I
H
V
T
V
A
A
P
E
G
F
L
----
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
A
D
-
S
D
A
I
V
L
H
C
L
P
A
-----------------
H
R
------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
-----------------------------
87
PsiBlast_CBE
74.26
36%
-94
- C7 -
2I6U
5
OTC_MYCTU
A:
[3-304]
----
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
--
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
--
K
G
-
A
L
R
G
L
R
L
S
Y
F
G
D
G
A
-
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
-
G
I
H
V
T
V
A
A
P
E
G
F
L
----
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
-
L
A
D
-
S
D
A
I
V
L
H
C
L
P
A
-----------------
H
R
------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
-----------------------------
115
HHSearch
73.85
36%
-91
- C7 -
2I6U
5
OTC_MYCTU
A:
[2-306]
---
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
---
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
G
A
--
L
-
R
G
L
R
L
S
Y
F
G
D
-
G
-
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
-
G
I
H
V
T
V
A
A
P
E
G
F
L
----
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
E
N
D
-
G
L
D
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
A
-
L
A
D
-
S
D
A
I
V
L
H
C
L
P
A
-----------------
H
R
------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
---------------------------