@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0267: (2016-03-13 )
MKLTGIHHVSIFTANARANFDFYTKIMGLRLVKKSVNQDDPYTYHLYYGDEIGSPGTALTFFEVPNMAKNHPSRNAISGLSLRVPSDEALHYWDKRLDEHRIFHSKPIDQFGRKIIRLKDTDGLPVNLISDETSTQVTEVTPWEDSLVPAEYAIRGLGPVRFSVFKKEKTDRLLTKILGFERIGAYEDDDKLVTVFKTGNVGLGGEVHVESRPDLEQGNLGAGGIHHVAFRVPTDGDLIGWTEMIQDLGYKNSGYVDRFYFHSLYFRESNGILIELATDEPGFQTDFTKEHGTYVDLPPHLEERREDILAHLKPLDTDK
Atome Classification :
(20 SA)
---------------.........10.--.......20........30........40-.-...-....50-------.........60.......------------------------.---------70........80....--....90........100......-.-.----.----110.-..-----.....120-.......130.....--.----.140---.-.-.-------.--------.---.---.150.-----......160..--.-----.--...170.......180......---.-----190--------.---------.-.-......200--........---.210...--.-----.------..--220.......230.......240..-....----.250-...-...---.-260---------------------.-----.......-.270......----.280-----------------------.........-290-........300.......310.......-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MKL
T
G
I
H
H
V
S
I
F
--
T
ANARAN
F
D
F
Y
T
K
I
M
G
L
R
L
V
K
K
SVNQDD
P
-
Y
-
T
Y
H
-
L
Y
YGD--------EIGSPG
T
A
L
T
F
FEVPNMA------------------------K---------NHPSRNAIS
G
L
S
L
RVP--S
D
E
A
L
H
Y
W
D
K
RLDEH--RIFHSK-
P
-
I
----
D
----
Q
-
F
G
-
R
K
-----
I
I
R
LKDTD-GL
P
V
N
L
ISDETST
Q
V
--
T
----
E
VTP---W-E-D-------S--------L---V---
P
A
E
Y
A
-----IRGLGPV
R
F
S
V
--
F
-----K--K
E
K
T
D
R
L
L
T
K
I
L
G
F
E
RIGAYED---D-----D----------
K
---------
L
-
V
-
T
V
F
KTGN----VGLG
G
E
V
H
---VESRPDL--E-----Q------GN--LGAGG
I
H
H
V
A
F
RVPTDGDLI
G
W
T
E
M
-
I
Q
DL----GYKN-SG
Y
-
V
D
R
---
F
-
Y
-----------------------
F
-----
H
S
L
Y
F
RE-SN
G
I
L
I
E
LAT----DE-------------------------PGFQTDFTK-E-H-G
T
Y
VDLPP
H
L
E
E
R
R
E
D
I
L
A
H
LKPLDTDK-----------------------
45
Fugue
98.81
41%
-80
- C2 -
1ZSW
2
?
A:
[11-338]
VDLGTENLYFQSNAM
Y
E
I
K
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
P
-
S
-
M
Y
H
-
L
F
Y
G
D
--------
K
T
G
S
P
G
T
E
L
S
F
F
E
I
P
L
V
G
------------------------
R
---------
T
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
--
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
--
D
V
K
H
S
E
-
M
-
T
----
T
----
Y
-
A
N
-
R
P
-----
A
L
Q
F
E
D
A
E
-
G
L
R
L
V
L
L
V
S
N
G
E
K
V
---
E
----
H
W
E
T
---
W
-
E
-
K
-------
S
--------
E
---
V
---
P
A
K
H
Q
-----
I
Q
G
M
G
S
V
E
L
T
V
--
R
-----
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
D
Q
--------------------------------
E
-
A
I
F
Q
S
I
K
----
G
E
A
F
G
E
I
V
---
V
K
Y
L
D
G
---
P
-----
T
------
E
K
--
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
-
V
K
Q
R
----
G
F
H
S
-
S
G
I
-
I
D
R
---
F
-
Y
-----------------------
F
-----
K
S
L
Y
F
R
E
-
S
N
G
I
L
F
E
I
A
T
----
D
G
-------------------------
P
G
F
T
V
D
G
D
V
-
E
-
H
L
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
E
K
------------------------
1
PsiBlast_PDB
98.00
41%
-81
- C2 -
1ZSW
2
?
A:
[27-336]
----------------
E
I
K
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
P
-
S
-
M
Y
H
-
L
F
Y
G
D
--------
K
T
G
S
P
G
T
E
L
S
F
F
E
I
P
L
V
G
------------------------
R
---------
T
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
--
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
--
D
V
K
H
S
E
-
M
-
T
----
T
----
Y
-
A
N
-
R
P
-----
A
L
Q
F
E
D
A
E
-
G
L
R
L
V
L
L
V
S
-
N
G
E
K
V
--
E
----
H
W
E
T
---
W
-
E
-
K
-------
S
--------
E
---
V
---
P
A
K
H
Q
-----
I
Q
G
M
G
S
V
E
L
T
V
--
R
-----
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
D
Q
---
E
------------------------------
A
I
F
Q
S
I
K
----
G
E
A
F
G
E
I
V
---
V
K
Y
L
-
D
G
--
P
-----
T
------
E
K
--
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
-
V
K
Q
R
----
G
F
H
S
-
S
G
I
-
I
D
R
---
F
-
Y
-----------------------
F
-----
K
S
L
Y
F
R
E
-
S
N
G
I
L
F
E
I
A
T
----
D
G
-------------------------
P
G
F
T
V
D
G
D
V
-
E
-
H
L
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
--------------------------
23
HHSearch
95.55
41%
-78
- C2 -
1ZSW
2
?
A:
[26-336]
---------------
Y
E
I
K
G
H
H
H
I
S
M
V
--
T
K
N
A
N
E
N
N
H
F
Y
K
N
V
L
G
L
R
R
V
K
M
T
V
N
Q
D
D
P
-
S
-
M
Y
H
-
L
F
Y
G
D
--------
K
T
G
S
P
G
T
E
L
S
F
F
E
I
P
L
V
G
------------------------
R
---------
T
Y
R
G
T
N
A
I
T
R
I
G
L
L
V
P
--
S
E
D
S
L
H
Y
W
K
E
R
F
E
K
F
--
D
V
K
H
S
E
-
M
-
T
----
T
----
Y
-
A
N
-
R
P
-----
A
L
Q
F
E
D
A
E
-
G
L
R
L
V
L
L
V
S
N
G
E
K
V
---
E
----
H
W
E
T
---
W
-
E
-
K
-------
S
--------
E
---
V
---
P
A
K
H
Q
-----
I
Q
G
M
G
S
V
E
L
T
V
--
R
-----
R
--
L
D
K
M
A
S
T
L
T
E
I
F
G
Y
T
E
V
S
R
N
D
-------------------------------
Q
-
E
-
A
I
F
Q
S
I
K
-----
G
E
A
F
G
E
I
---
V
V
K
Y
L
D
G
--
P
-----
T
------
E
K
--
P
G
R
G
S
I
H
H
L
A
I
R
V
K
N
D
A
E
L
A
Y
W
E
E
Q
-
V
K
Q
R
----
G
F
H
S
-
S
G
I
-
I
D
R
---
F
-
Y
-----------------------
F
-----
K
S
L
Y
F
R
E
-
S
N
G
I
L
F
E
I
A
T
----
D
G
-------------------------
P
G
F
T
V
D
G
D
V
-
E
H
L
-
G
E
K
L
D
L
P
P
F
L
E
D
Q
R
A
E
I
E
A
N
L
A
P
I
E
--------------------------
2
PsiBlast_PDB
90.82
35%
-74
- C2 -
3OAJ
2
MHQO_BACSU
A:
[5-309]
----------------
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
P
-
G
-
T
Y
H
-
L
Y
F
G
N
--------
E
G
G
K
P
G
T
I
I
T
F
F
P
W
A
G
A
R
------------------------
Q
---------
G
V
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
--
K
G
-
A
M
A
F
W
E
K
R
L
E
K
F
--
N
V
P
Y
T
K
---
I
----
E
----
R
-
F
G
-
E
Q
-----
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
E
R
E
E
G
----------
E
A
N
T
---
W
-
T
-
F
-------
G
--------
E
---
V
---
T
P
D
V
A
-----
I
K
G
F
G
G
A
T
L
L
S
--
E
-----
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
G
D
---
F
-----
V
----------
R
---------
Y
-
R
-
S
A
G
D
I
G
N
----
V
-----
I
D
---
L
K
L
T
P
-
I
--
G
-----
R
------
G
Q
--
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
-
I
A
S
H
----
G
Y
G
V
-
T
P
V
-
R
D
R
---
N
-
Y
-----------------------
F
-----
N
A
I
Y
F
R
E
-
H
G
E
I
L
F
E
I
A
T
----
D
P
-------------------------
P
G
F
A
H
D
E
T
Q
-
E
T
M
-
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
-------------------------
21
PsiBlast_CBE
90.44
35%
-75
- C2 -
3OAJ
2
MHQO_BACSU
B:
[5-309]
----------------
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
P
-
G
-
T
Y
H
-
L
Y
F
G
N
--------
E
G
G
K
P
G
T
I
I
T
F
F
P
W
A
G
A
R
------------------------
Q
---------
G
V
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
--
K
G
-
A
M
A
F
W
E
K
R
L
E
K
F
--
N
V
P
Y
T
K
---
I
----
E
----
R
-
F
G
-
E
Q
-----
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
E
R
E
E
G
----------
E
A
N
T
---
W
-
T
-
F
-------
G
--------
E
---
V
---
T
P
D
V
A
-----
I
K
G
F
G
G
A
T
L
L
S
--
E
-----
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
G
D
---
F
-----
V
----------
R
---------
Y
-
R
-
S
A
G
D
I
G
N
----
V
-----
I
D
---
L
K
L
T
P
-
I
--
G
-----
R
------
G
Q
--
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
-
I
A
S
H
----
G
Y
G
V
-
T
P
V
-
R
D
R
---
N
-
Y
-----------------------
F
-----
N
A
I
Y
F
R
E
-
H
G
E
I
L
F
E
I
A
T
----
D
P
-------------------------
P
G
F
A
H
D
E
T
Q
-
E
T
M
-
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
-------------------------
22
HHSearch
89.10
34%
-68
- C2 -
3OAJ
2
MHQO_BACSU
A:
[4-309]
---------------
K
K
T
M
G
I
H
H
I
T
A
I
--
V
G
H
P
Q
E
N
T
D
F
Y
A
G
V
L
G
L
R
L
V
K
Q
T
V
N
F
D
D
P
-
G
-
T
Y
H
-
L
Y
F
G
N
--------
E
G
G
K
P
G
T
I
I
T
F
F
P
W
A
G
A
R
------------------------
Q
G
V
-------
I
G
D
G
Q
V
G
V
T
S
Y
V
V
P
K
G
--
A
---
M
A
F
W
E
K
R
L
E
K
F
--
N
V
P
Y
T
K
-
I
------
E
----
R
-
F
G
-
E
Q
-----
Y
V
E
F
D
D
P
H
-
G
L
H
L
E
I
V
E
R
E
E
G
E
A
----------
N
T
---
W
-
T
-
F
-------
G
--------
E
---
V
---
T
P
D
V
A
-----
I
K
G
F
G
G
A
T
L
L
S
--
E
-----
Q
--
P
D
K
T
A
D
L
L
E
N
I
M
G
L
E
R
V
G
K
E
G
-------------------------------
D
-
F
-
V
R
Y
R
S
A
G
-----
D
I
G
N
V
I
D
---
L
K
L
T
P
I
---
G
-----
R
------
G
Q
--
M
G
A
G
T
V
H
H
I
A
W
R
A
N
D
D
E
D
Q
L
D
W
Q
R
Y
-
I
A
S
H
----
G
Y
G
V
-
T
P
V
-
R
D
R
---
N
-
Y
-----------------------
F
-----
N
A
I
Y
F
R
E
-
H
G
E
I
L
F
E
I
A
T
----
D
P
-------------------------
P
G
F
A
H
D
E
T
Q
E
T
-
M
-
G
E
K
L
M
L
P
V
Q
Y
E
P
H
R
T
Q
I
E
Q
G
L
L
P
F
E
V
-------------------------
3
PsiBlast_PDB
84.60
31%
-70
- C2 -
4HUZ
2
?
A:
[6-286]
-----------------
I
T
S
L
H
H
I
T
I
C
--
T
G
T
A
Q
G
D
I
D
F
F
V
K
V
M
G
Q
R
F
V
K
R
T
L
F
Y
D
G
S
-
I
P
I
Y
H
-
L
Y
F
A
D
--------
E
L
G
T
P
G
T
V
M
T
T
F
P
T
R
R
T
G
Q
-----------------------
K
---------
G
R
K
G
S
N
Q
F
T
V
C
T
Y
A
I
P
--
K
G
-
S
L
E
W
W
I
G
H
L
N
A
H
--
G
I
A
T
G
E
-
P
-
G
----
T
----
R
-
F
G
-
Q
R
-----
Y
V
G
F
Q
H
P
D
C
G
I
D
F
E
V
L
E
D
E
N
D
T
R
----------
Q
P
---
Y
-
D
-
S
-------
P
--------
Y
---
V
---
P
I
E
H
A
-----
Q
R
G
F
H
S
W
T
A
S
V
--
R
-----
E
--
L
E
D
M
D
F
F
M
E
N
C
W
N
F
E
K
I
G
--
E
E
---
G
-----
N
----------
R
---------
H
-
R
-
Y
R
V
K
-
G
T
----
T
E
S
G
T
I
I
D
---
L
L
H
E
P
D
R
--
R
-----
Q
------
G
S
WT
I
A
E
G
I
I
H
H
G
A
F
A
V
P
-
D
M
D
I
Q
A
R
I
K
F
E
T
E
G
V
----
G
F
T
D
F
S
D
R
-
K
N
R
---
G
-
Y
-----------------------
F
-----
E
S
T
Y
V
R
T
-
P
G
G
V
M
F
E
-
A
T
----
H
S
-------------------------
L
G
F
T
H
D
-----------------------------------------------------------
28
HHSearch
70.88
17%
-84
- C2 -
1MPY
2
XYLE1_PSEPU
A:
[3-276]
---------------
K
G
V
M
R
P
G
H
V
Q
L
R
--
V
L
D
M
S
K
A
L
E
H
Y
V
E
L
L
G
L
I
E
M
D
R
D
D
---
Q
G
-
R
-
V
Y
L
-
K
A
W
T
-----------
E
V
D
K
F
S
L
V
L
R
E
A
-----------------------------------------
D
E
P
G
M
D
F
M
G
F
K
V
V
--
D
E
D
A
L
R
Q
L
E
R
D
L
M
A
Y
--
G
C
A
V
E
Q
L
P
-
A
GE--
L
----
N
-
S
C
-
G
R
-----
R
V
R
F
Q
A
P
S
-
G
H
H
F
E
L
Y
A
D
K
E
Y
T
G
K
--
W
----
G
L
N
D
---
V
-
N
-
P
-------
E
--------
A
---
W
PRD
L
K
G
M
A
-----
A
V
R
F
D
H
A
L
M
Y
G
--
D
-----
E
--
L
P
A
T
Y
D
L
F
T
K
V
L
G
F
Y
L
A
E
Q
V
L
D
---
E
-----
N
----------
G
T--------
R
-
V
-
A
Q
F
L
S
L
-----
S
T
K
A
H
D
V
A
---
F
I
H
H
P
----------------------
E
K
G
R
L
H
H
V
S
F
H
L
E
T
W
E
D
L
L
R
A
A
D
L
-
I
S
M
T
----
D
T
S
I
-
D
I
G
-
P
T
R
HGL
T
-
H
-----------------------
G
-----
K
T
I
Y
F
F
D
-
P
S
G
N
R
N
E
V
F
C
----
G
G
-------------------------
D
Y
N
Y
P
D
-----------------------------------------------------------
48
Fugue
69.74
17%
-69
- C2 -
1MPY
2
XYLE1_PSEPU
A:
[1-307]
-------------MN
K
G
V
M
R
P
G
H
V
Q
L
R
--
V
L
D
M
S
K
A
L
E
H
Y
V
E
L
L
G
L
----
I
E
M
D
R
D
D
Q
-
G
-
R
V
Y
-
L
K
A
W
T
--------
E
V
D
K
F
S
L
V
L
R
E
-------------------------------------------
A
D
E
P
G
M
D
F
M
G
F
K
V
V
--
D
E
D
A
L
R
Q
L
E
R
D
L
M
A
Y
--
G
C
A
V
E
Q
-
L
-
P
----
A
----
G
-
E
L
---NSC
G
R
R
V
R
F
Q
A
P
S
-
G
H
H
F
E
L
Y
A
D
K
E
Y
T
G
K
--
W
----
G
L
N
D
---
V
-
N
-
P
-------
E
--------
A
---
W
---
P
R
D
L
K
GMAAV--
R
F
D
H
A
L
M
Y
G
--
D
-----
E
--
L
P
A
T
Y
D
L
F
T
K
V
L
G
F
Y
L
A
E
Q
V
L
D
---
E
----------------------------
N
-
G
T
R
V
A
Q
F
----
L
S
L
S
T
K
A
H
D
V
A
F
I
H
H
P
E
----------------------
K
G
R
L
H
H
V
S
F
H
L
E
T
W
E
D
L
L
R
A
A
D
L
-
I
S
M
T
----
D
T
S
I
-
D
I
G
-
P
T
R
---
H
-
G
-----------------------
L
TH
G
--
K
T
I
Y
F
F
D
P
S
-
G
N
R
N
E
V
F
C
----
G
G
-------------------------
D
Y
N
Y
P
D
H
K
P
-
V
-
T
-
W
T
T
D
Q
L
G
K
A
I
F
Y
H
D
R
I
L
N
E
R
F
M
T
V
L
T
-------------------------
27
HHSearch
67.44
19%
-73
- C2 -
3LM4
3
?
A:
[7-278]
---------------
F
D
I
A
H
L
A
R
A
E
L
F
--
S
P
K
P
Q
E
T
L
D
F
F
T
K
F
L
G
M
Y
V
T
H
R
E
G
----
Q
-
S
-
V
Y
L
-
R
G
Y
E
D
-----------
P
Y
P
W
S
L
K
I
T
E
-----------------------------------------
A
P
E
A
G
M
G
H
A
A
M
R
T
S
--
S
P
E
A
L
E
R
R
A
K
S
L
T
D
G
--
N
V
D
G
T
W
-
S
-
E
D---
Q
----
F
-
G
Y
-
G
K
-----
T
F
E
Y
Q
S
P
D
-
G
H
N
L
Q
L
L
W
E
A
E
K
Y
V
A
--
P
----
P
E
L
R
SKI
L
T
R
-
P
-------
S
--------
K
K--
P
---
L
Q
G
I
P
-----
V
K
R
I
D
H
L
N
L
M
S
--
S
-----
D
--
V
T
A
V
K
D
S
F
E
R
H
L
G
F
R
T
T
E
R
V
V
D
---
G
-----
N
----------
V
---------
E
-
I
-
G
A
W
M
S
S
N
-----
L
L
G
H
E
V
A
---
C
M
R
D
M
T
--------------------
G
G
H
G
K
L
H
H
L
A
F
F
Y
G
T
G
Q
H
N
I
D
A
V
E
M
-
F
R
D
Y
----
D
I
Q
I
-
E
A
G
-
P
D
K
---
H
-
G
ITQ--------------------
S
-----
Q
F
L
Y
V
F
E
-
P
G
G
N
R
I
E
L
F
G
----
E
A
-------------------------
G
Y
L
H
-------------------------------------------------------------
25
HHSearch
65.08
16%
-76
- C2 -
2WL9
4
?
A:
[2-281]
---------------
A
K
V
T
E
L
G
Y
L
G
L
S
--
V
S
N
L
D
A
W
R
D
Y
A
A
G
I
M
G
M
Q
V
V
D
D
G
E
---
D
D
-
R
-----
I
Y
L
R
M
----------
D
R
W
H
H
R
I
V
L
H
A
D
-----------------------------------------
G
S
D
D
L
A
Y
I
G
W
R
V
A
--
G
P
V
E
L
D
E
L
A
E
Q
L
K
N
A
--
G
I
P
F
E
V
-
A
S
D
----
A
D
A
A
E
R
-
R
V
-
L
G
-----
L
V
K
L
H
D
P
G
-
G
N
P
T
E
I
F
Y
G
P
Q
V
D
T
S
---------
S
P
---
F
-
H
-
P
-------
G
RPM-----
F
---
G
---
K
F
V
T
E
-----
G
Q
G
L
G
H
I
I
I
R
E
--
D
-----
D
--
V
E
E
A
T
R
F
Y
R
-
L
L
G
L
E
G
A
V
E
Y
K
F
A
L
P
N
-----
G
A
---------
V
---------
G
-
T
-
P
V
F
M
H
C
-----
N
D
R
H
H
S
L
A
---
F
G
V
G
P
----------------------
M
D
K
R
I
N
H
L
M
I
E
Y
T
H
L
D
D
L
G
Y
A
H
D
L
-
V
R
Q
Q
----
K
I
D
V
-
T
L
Q
-
I
G
K
H
SN
D
-
E
-----------------------
A
-----
L
T
F
Y
C
A
N
-
P
S
G
W
L
W
E
P
G
W
----
G
S
-------------------------
R
P
A
P
A
Q
Q
E
H
Y
L
-
R
-
D
--------------------------------------------------
52
Fugue
65.07
16%
-52
- C2 -
1Q0O
1
?
A:
[4-359]
------E
I
P
K
P
VAPA
P
D
I
L
R
C
A
Y
A
E
L
V
--
V
T
D
L
A
K
S
R
N
F
Y
V
D
V
L
G
L
H
V
S
Y
E
-----
D
E
-
N
-
Q
I
Y
-
L
R
S
F
E
--------
E
F
I
H
H
N
L
V
L
T
K
-------------------------------------------
G
P
V
A
A
L
K
A
M
A
F
R
V
R
--
T
P
E
D
V
D
K
A
E
A
Y
Y
Q
E
L
G
C
R
T
E
R
R
K
-
D
-
G
----
F
----
V
-
K
G
I
G
D
-----
A
L
R
V
E
D
P
L
-
G
F
P
Y
E
F
F
F
E
T
T
H
V
E
R
--
L
----
H
M
R
Y
---
D
-
L
-
Y
-------
S
------------------
A
G
E
-----
L
V
R
L
D
H
F
N
Q
V
T
--
P
-----
D
--
V
P
R
G
R
K
Y
L
E
D
-
L
G
F
R
V
T
E
D
I
Q
D
---
D
-----
E
----------
G
---------
T
-
T
-
Y
A
A
W
M
H
R
----
K
G
T
V
H
D
T
A
---
L
T
G
G
N
-----------------------
G
P
R
L
H
H
V
A
F
S
T
H
E
K
H
N
I
I
Q
I
C
D
K
-
M
G
A
L
----
R
I
S
D
-
R
I
E
-
R
G
P
---
G
-
R
-----------------------
H
GVSN
A
F
Y
L
Y
I
L
D
-
P
D
N
H
R
I
E
I
Y
T
----
Q
D
Y
Y
TGDPDN
P
T
I
T
W
N
VHDNQRRDWWG
N
P
V
V
P
S
W
Y
T
-
E
-
A
-
S
K
V
L
D
L
D
G
N
V
Q
E
I
I
E
R
T
D
D
S
E
L
E
V
T
I
G
A
D
G
F
S
F
TRAGDEDGSYHGQASKGF
33
HHSearch
64.01
15%
-71
* C2 *
1T47
2
HPPD_STRAW
A:
[18-341]
---------------
F
P
V
K
G
M
D
A
V
V
F
A
--
V
G
N
A
K
Q
A
A
H
Y
Y
S
T
A
F
G
M
Q
L
V
A
Y
S
G
P
E
N
G
S
-
R
E
T
A
S
-
Y
V
L
T
------------
N
G
S
A
R
F
V
L
T
S
V
I
K
P
A
------------------------
T
P
W
G
H
F
L
A
D
H
V
A
E
H
G
D
G
V
V
D
L
A
I
E
V
P
--
D
---
A
R
A
A
H
A
Y
A
I
E
H
--
G
A
R
S
V
A
E
P
-
Y
E
L
K
D
E
----
H
-
G
T
-
V
V
-----
L
A
A
I
A
T
Y
G
-
K
T
R
H
T
L
V
D
R
T
G
Y
D
G
P
YL
P
----
G
Y
V
A
---
A
-
A
-
P
-------
I
V-------
E
---
P
---
P
A
H
R
T
-----
F
Q
A
I
D
H
C
V
G
N
V
E
L
G
-----
R
--
M
N
E
W
V
G
F
Y
N
K
V
M
G
F
T
N
M
K
E
F
V
G
---
D
DIA--
T
EYS-------
A
---------
L
-
M
-
S
K
V
V
A
D
G
-----
T
L
K
V
K
F
P
---
I
N
E
P
A
L
A
KK
K
-----
S
Q
I
D
E
Y
L
E
F
--
Y
G
G
A
G
V
Q
H
I
A
L
N
T
G
D
---
I
V
E
T
V
R
T
-
M
R
A
A
----
G
V
Q
F
-
L
D
T
-
P
D
S
---
Y
-
Y
D
T
L
GEWVGDTRVP
V
D
T
L
R
E
----
L
-----
K
I
L
A
D
R
D
-
E
D
G
Y
L
L
Q
I
F
T
----
K
P
-------------------------
V
Q
---------------------------------------------------------------
24
HHSearch
61.94
16%
-80
- C2 -
3B59
1
?
A:
[4-259]
---------------
S
R
V
T
E
I
R
Y
V
G
Y
G
--
V
K
D
F
D
A
E
K
A
F
Y
A
D
V
W
G
L
E
P
V
G
E
D
A
----
N
-
N
-
A
W
F
-
K
A
Q
G
-----------
A
D
E
H
H
V
V
Q
L
R
R
-----------------------------------------
A
D
E
N
R
I
D
V
I
A
L
A
A
D
--
S
R
S
D
V
D
A
L
R
A
S
V
E
A
A
--
G
C
K
V
A
S
E
P
-
A
VLA-
T
----
P
-
G
G
-
G
Y
-----
G
F
R
F
F
S
P
D
-
G
L
L
F
E
V
S
S
D
V
A
K
G
A
---------
K
R
D
---
L
-
A
--------------------------
R
W
E
G
V
-----
P
V
K
I
S
H
I
V
L
H
S
--
P
-----
N
--
H
Q
D
M
V
K
F
F
T
D
V
L
G
F
K
V
S
D
W
L
G
-------------------------------
D
-
F
-
M
C
F
L
R
C
N
-----
S
A
H
H
R
I
A
---
I
L
P
G
------------------------
P
P
C
L
N
H
V
A
Y
D
M
L
S
V
D
D
M
M
R
G
A
H
R
-
L
K
V
K
----
G
I
D
I
-
G
W
G
-
P
G
R
---
H
T
A
GN---------------------
N
-----
T
F
S
Y
F
V
T
-
P
G
G
F
V
T
E
Y
T
S
----
E
L
-------------------------
E
E
V
D
F
------------------------------------------------------------
30
HHSearch
61.86
13%
-78
- C2 -
3HPY
2
?
A:
[4-276]
---------------
T
G
V
L
R
P
G
H
A
Q
V
R
--
V
L
N
L
E
E
G
I
H
F
Y
R
N
V
L
G
L
V
E
T
G
R
D
D
Q
---
G
-
R
-
V
Y
--
F
K
C
W
-----------
D
E
R
D
H
S
C
Y
I
I
R
E
----------------------------------------
A
D
T
A
G
I
D
F
F
G
F
K
V
L
--
D
K
A
T
L
E
K
L
D
A
D
L
Q
A
Y
--
G
L
T
T
T
R
I
P
-
A
GE--
M
----
L
-
E
T
-
G
E
-----
R
V
R
F
E
L
P
S
-
G
H
L
I
E
L
Y
A
E
K
T
C
V
G
N
--
G
ISEV
N
P
A
P
---
W
-
N
-
A
-------
Q
--------
R
-------
E
H
G
I
A
-----
P
I
Q
L
D
H
C
L
L
Y
G
--
P
-----
N
--
I
A
E
V
Q
K
I
F
T
E
V
L
G
F
Y
L
V
E
R
V
L
S
---
P
-----
D
GD--------
S
---------
D
-
M
-
G
I
W
L
S
C
-----
S
H
K
V
H
D
I
A
---
F
V
E
Y
P
----------------------
E
K
G
K
L
H
H
C
S
F
L
L
E
S
W
E
Q
V
L
R
A
G
D
I
-
M
S
M
N
----
E
V
N
V
-
D
I
G
-
P
T
R
H--
G
-
V
TR---------------------
G
-----
C
T
I
Y
A
W
D
-
P
S
G
N
R
F
E
T
F
M
----
G
G
-------------------------
Y
H
P
Y
-------------------------------------------------------------
39
HHSearch
61.40
15%
-74
- C2 -
1SQD
1
HPPD_ARATH
A:
[21-373]
---------------
F
K
V
K
R
F
H
H
I
E
F
W
--
C
G
D
A
T
N
V
A
R
R
F
S
W
G
L
G
M
R
F
S
A
K
S
D
L
S
T
G
N
M
V
-
H
A
S
-
Y
L
L
T
------------
S
G
D
L
R
F
L
F
T
A
P
Y
S
P
S
LSAGEIKPTTTASIPSFD
H
G
S
C
R
S
F
---------
F
S
S
H
G
L
G
V
R
A
V
A
I
E
V
E
--
D
---
A
E
S
A
F
S
I
S
V
A
N
--
G
A
I
P
S
S
P
P
-
I
----
V
----
L
N
E
A
-
V
T
-----
I
A
E
V
K
L
Y
G
-
D
V
V
L
R
Y
V
S
Y
K
A
E
-----------------
F
-
L
-
P
-------
G
FERVEDAS
S
---
F
---
P
L
D
Y
G
-----
I
R
R
L
D
H
A
V
G
N
V
--
P
-----
E
--
L
G
P
A
L
T
Y
V
A
G
F
T
G
F
H
Q
F
A
E
F
T
-----------S---------
G
---------
L
-
N
-
S
A
V
L
A
S
N
-----
D
E
M
V
L
L
P
---
I
N
E
P
V
H
G
K-
S
Q
I
Q
T
Y
L
------
E
H
--
N
E
G
A
G
L
Q
H
L
A
L
M
S
E
D
---
I
F
R
T
L
R
E
-
M
R
K
R
S
SIG
G
F
D
F
-
M
P
S
P
P
P
T
---
Y
-
Y
Q
N
L
K
K
R
VGDVLS
D
D
Q
I
K
E
C
E
E
--
L
-----
G
I
L
V
D
R
D
-
D
Q
G
T
L
L
Q
I
F
T
----
K
P
-------------------------
L
G
D
--------------------------------------------------------------
29
HHSearch
61.13
15%
-77
- C2 -
2ZYQ
1
HSAC_MYCTU
A:
[2-276]
----------------
S
I
R
S
L
G
Y
L
R
I
E
--
A
T
D
M
A
A
W
R
E
Y
G
L
K
V
L
G
M
V
E
G
K
G
A
P
E
---
G
-
A
-----
L
Y
L
R
M
----------
D
D
F
P
A
R
L
V
V
V
P
G
-----------------------------------------
E
H
D
R
L
L
E
A
G
W
E
C
A
--
N
A
E
G
L
Q
E
I
R
N
R
L
D
L
E
--
G
T
P
Y
K
E
A
T
-
A
A
E
L
A
D
----
R
-
R
V
-
D
E
-----
M
I
R
F
A
D
P
S
-
G
N
C
L
E
V
F
H
G
T
A
L
E
H
----------
R
R
---
V
-
V
S
P
-------
Y
--------
G
---
H
---
R
F
V
T
G
-----
E
Q
G
M
G
H
V
V
L
S
T
--
R
-----
D
--
D
A
E
A
L
H
F
Y
R
D
V
L
G
F
R
L
R
D
S
M
R
L
---
P
-----
P
QMVGRPAD
G
P
P
---------
A
-
W
-
L
R
F
F
G
C
-----
N
P
R
H
H
S
L
A
---
F
L
P
M
----------------------
P
T
S
S
G
I
V
H
L
M
V
E
V
E
Q
A
D
D
V
G
L
C
L
D
R
-
A
L
R
R
----
K
V
P
M
-
S
A
T
-
L
G
R
H
VN
D
-
L
-----------------------
M
-----
L
S
F
Y
M
K
T
-
P
G
G
F
D
I
E
F
G
C
----
E
G
-------------------------
R
Q
V
D
D
------------------------------------------------------------
26
HHSearch
59.39
15%
-74
- C2 -
3VB0
3
?
A:
[2-273]
----------------
S
V
K
Q
L
G
Y
L
I
F
E
C
R
A
D
V
L
E
Q
M
V
V
V
Y
Q
D
I
I
G
A
V
V
E
R
D
E
G
----
G
-
R
-----
A
L
V
R
L
----------
D
G
R
P
F
R
I
R
L
D
P
-----------------------------------------
G
P
A
N
R
L
A
A
I
G
W
N
V
---
D
P
S
D
L
A
A
I
A
E
Q
V
E
K
A
--
C
Y
S
V
V
T
A
D
-
A
E
L
A
A
D
----
R
-
A
A
-
A
Q
-----
V
R
Q
F
A
D
N
D
-
G
F
T
H
E
L
Y
V
E
S
S
F
P
T
----------
D
P
---
V
-
L
-
E
-------
S
--------
L
FVC
G
---
E
E
A
N
G
-----
I
F
G
L
G
H
L
V
V
I
V
--
A
-----
D
--
R
A
K
T
Q
S
F
F
T
D
V
L
G
F
G
L
S
D
R
V
T
W
---
P
-----
E
----------
A
---------
D
-
I
-
F
F
L
H
C
N
------
Q
R
H
H
T
V
A
---
L
S
A
P
A
L
-----------------
G
--
L
K
P
G
M
V
H
H
L
M
L
E
A
K
S
K
E
Q
V
D
R
A
F
A
A
-
V
K
R
L
----
G
Y
D
V
-
L
M
T
-
I
G
Q
H
SN
D
-
K
-----------------------
V
-----
Y
S
F
Y
M
M
A
-
P
A
G
F
A
V
E
L
G
F
----
G
G
-------------------------
Q
V
I
G
D
L
E
S
---------------------------------------------------------
54
Fugue
59.24
14%
-51
- C2 -
1T47
2
HPPD_STRAW
A:
[16-377]
-------------DP
F
P
V
K
G
M
D
A
V
V
F
A
--
V
G
N
A
K
Q
A
A
H
Y
Y
S
T
A
F
G
M
Q
L
V
A
Y
S
G
P
E
N
G
S
-
R
-
E
T
A
-
S
Y
V
L
T
N
GS
A
R
F
V
L
T
S
V
I
K
P
A
T
P
W
G
H
F
L
A
D
H
V
------------------------
A
---------
E
H
G
D
--
G
V
V
D
L
A
I
E
V
P
D
A
R
A
A
H
A
Y
A
I
E
H
G
A
R
S
V
--
A
E
P
Y
E
L
-
K
-
D
----
E
----
H
-
G
T
-
V
V
-----
L
A
A
I
A
T
Y
G
-
K
T
R
H
T
L
V
D
R
T
G
Y
D
G
P
--
Y
----
L
P
G
Y
---
V
-
A
-
A
-------
A
--------
P
---
I
---
V
E
P
P
A
-----
H
R
T
F
Q
A
I
D
H
C
V
--
G
N
V
E
LG
R
--
M
N
E
W
V
G
F
Y
N
K
V
M
G
F
T
N
M
K
E
F
V
G
---
D
-----
D
----------
I
ATEYSA
L
M
S
K
-
V
-
V
A
D
G
T
L
K
V
K
F
P
I
N
E
P
A
L
A
K
---
K
K
S
Q
I
D
E
--
Y
-----
L
------
E
F
--
Y
G
G
A
G
V
Q
H
I
A
L
N
T
G
---
D
I
V
E
T
V
R
T
-
M
R
A
A
----
G
V
Q
F
-
L
D
T
-
P
D
S
---
Y
-
Y
D
T
L
GEWVGDTRVP
V
D
T
L
R
E
----
L
-----
K
I
L
A
D
R
D
-
E
D
G
Y
L
L
Q
I
F
T
KPVQ
D
R
-------------------------
P
T
V
F
F
E
I
I
E
-
R
-
H
-
G
S
M
G
F
G
K
G
N
F
K
A
L
F
E
A
I
E
R
E
Q
E
K
----------------------------
36
HHSearch
58.47
13%
-76
- C2 -
3ISQ
7
HPPD_HUMAN
A:
[7-335]
---------------
G
R
F
L
H
F
H
S
V
T
F
W
--
V
G
N
A
K
Q
A
A
S
F
Y
C
S
K
M
G
F
E
P
L
A
Y
R
G
L
E
T
G
S
-
R
-
E
V
V
S
H
V
I
K
------------
Q
G
K
I
V
F
V
L
S
S
A
L
N
P
W
NK
E
M
G
D
------------------
H
---------
L
V
K
H
G
D
G
V
K
D
I
A
F
E
V
E
--
D
---
C
D
Y
I
V
Q
K
A
R
E
R
--
G
A
K
I
M
R
E
P
-
W
----
V
E
Q
D
K
F
-
G
K
-
V
K
-----
F
A
V
L
Q
T
Y
G
-
D
T
T
H
T
L
V
E
K
M
N
Y
I
G
--------
Q
F
L
P
G--
Y
-
E
-
A
PAFMD
P
L
L
--------
P
---
K
---
L
P
K
C
S
-----
L
E
M
I
D
H
I
V
G
N
Q
--
P
-----
D
QE
M
V
S
A
S
E
W
Y
L
K
N
L
Q
F
H
R
F
W
S
V
D
D
---
T
QVHTE
Y
----------
S
---------
S
L
R
S
I
V
V
A
N
Y
------
E
E
S
I
K
M
P
---
I
N
E
P
A
P
G
KK
K
-----
S
Q
I
Q
E
Y
V
D
Y
--
N
G
G
A
G
V
Q
H
I
A
L
K
T
E
D
---
I
I
T
A
I
R
H
-
L
R
E
R
----
G
L
E
F
-
L
S
V
-
P
S
T
---
Y
-
Y
K
Q
L
R
E
K
L
K
T
AKIKVKEN
I
D
A
L
E
E
L
-----
K
I
L
V
D
Y
D
-
E
K
G
Y
L
L
Q
I
F
T
----
K
P
-------------------------
V
Q
D
--------------------------------------------------------------