@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0608: (2016-03-17 )
MSGPGPGGGMRMQTAAKPKNFKQTLFRLLGYMKPRSVAIIVVFIFAILSTIFNIFSPKELGKATTEIFKGVMSQDGINNDKIFNILMIVLVLYLGSSLFSFIQQYVMSSVAQRTVYDMRKDLKAKMARLPLKYYDTRSNGDILSRSVNDMDNIANTLQQSLTQAITAIVQMIGVLIMMLTISWQMTLIVLVTVPISIILVAIIAGRSQRYFGAQQRNLGILNDTVEETYGGQTIIKAFGQEKKTLVKFDEVNEDYFKAAKKAQFISGIMMPVMQFVGNLGYVGVCVAGGIFVTNGTLQVGDIQSFTQYVQLFTQPISSVANIANIIQSTIASAERVFEMMDEEEEKDEIPANVNQVAGEEHSIVFDHVKFGYTPDKPLMTDLNIHVEEGQMVAIVGPTGAGKTTIINLLMRFYDVDGGQIRMKGIDTRDMTKDAVREKFGMVLQDTWLFNGTIADNIAYGREGATKDEVIGAAKAAYADDFIRRLPNGYDTILNEEGSNISQGQKQLLTIARAILSDPSILILDEATSSVDTRTELNIQLAMGNLMEGRTSFVIAHRLSTIRDADLILVMNHGSVIEQGTHQELLDAKGFYADLYNSQFTGAQAV
Atome Classification :
(46 SA)
.........10.......--.20........30.......-.40........50........60........70........80--........90........---------100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290.......300.......310......-.320.......330.......340...-....350.---.......360--........370.--..--.--.---..380........390.......400.......410....---...420....--...430.......440.......-450......--------.460-.---.---......470.-......480.......490.......500.......510.......520.......530.......540....--.--..550.......560.-......570.......580...-.-.--..590......-.600...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGPGPGGG
M
R
M
QTAAKP--
K
N
F
K
Q
T
L
F
R
L
L
GYMKPR
S
V
A
-
I
I
V
V
F
I
F
A
I
L
S
T
I
F
N
IF
S
P
K
E
L
G
K
A
T
T
E
I
F
K
G
V
M
SQDGIN
N
D
K
--
I
F
N
I
L
M
I
V
L
V
L
Y
L
G
S
S
L
F
---------
S
F
I
Q
Q
Y
V
M
S
S
V
A
Q
R
T
V
Y
D
M
R
K
D
L
K
A
K
M
A
RLP
L
K
Y
Y
DTRSNG
D
I
L
S
R
S
VN
D
M
D
N
I
A
N
T
L
Q
Q
S
L
T
Q
A
I
T
A
I
V
Q
M
I
G
V
L
I
M
M
L
TIS
W
Q
M
T
L
I
V
L
V
TV
P
I
S
I
I
L
V
A
I
IAGRSQRYF-GAQQRNLGI
L
N
D
T
V
E
E
TYG
G
Q
T
I
I
K
A
FGQEK
K
T
L
V
K
F
D
EV
N
E
D
Y
F
K
A
A
K
K
A
Q
F
I
S
G
I
M
M
P
V
M
Q
F
V
GNLG
Y
V
G
V
C
VAG
G
I
F
V
TNG
T
L
Q
VG
D
I
Q
S
F
T
Q
Y
V
Q
L
F
T
Q
P
I
S
S
-
V
A
N
I
A
N
I
I
Q
S
T
I
A
S
A
E
R
V
F
E
M
MDE
E
E
E
-KDEIPA-
N
---
V
N
Q
VAGEEH---
S
I
V
F
DHVKFGYT--PD--K--P---
L
M
T
D
-
L
N
I
H
VEEG
Q
M
V
A
I
VGPTGA
G
K
T
T
I
I
N
L
L
M
R
F
YDVD---G
G
Q
I
R
M
KGI
D
--
T
R
D
M
T
K
D
A
V
R
E
K
F
G
M
V
L
Q
D
T
W
L
F-N
G
T
IADNIA--------YG-R-E---G---A
T
K
D
E
V
I
G
A
A
-
K
A
A
Y
A
D
D
F
I
R
RLPN
G
Y
D
T
I
LNEEGSN
I
S
Q
G
Q
K
Q
L
L
T
I
A
R
A
ILSDP
S
I
L
I
LDEATSSVDT
R
T
E
L
N
I
Q
L
AM
G
N
LM--E--GR
T
S
F
V
I
A
H
R
L
STIRD-A
D
L
I
L
V
MNHG
S
V
IEQG
T
H
Q
E
L
L
-D-A--KG
F
Y
A
D
LYNSQ-FTGAQAV
4
PsiBlast_PDB
89.40
44%
-110
- C1 -
4Q4J
-
Y288_THEMA
B:
[15-591]
----------------
K
P
AL
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
F
D
L
--
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
---------
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
-
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
-
K
D
D
P
D
A
V
E
---
L
R
E
V
R
G
E
------
I
E
F
K
N
V
W
F
S
Y
D
--
K
K
--
K
--
P
---
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
--
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
--------
Y
G
-
N
-
P
---
G
---
A
T
D
E
E
I
K
E
A
A
-
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
-
Y
------
1
PsiBlast_PDB
89.05
44%
-109
- C1 -
3QF4
1
Y288_THEMA
B:
[15-591]
----------------
K
P
A
L
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
F
D
L
--
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
---------
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
-
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
-
K
D
D
P
D
A
V
E
---
L
R
E
V
R
G
E
------
I
E
F
K
N
V
W
F
S
Y
D
--
K
K
--
K
--
P
---
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
--
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
--------
Y
G
-
N
-
P
---
G
---
A
T
D
E
E
I
K
E
A
A
-
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
-
Y
------
2
PsiBlast_PDB
88.81
44%
-111
- C1 -
4Q4A
1
Y288_THEMA
B:
[15-591]
----------------
K
P
AL
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
F
D
L
--
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
---------
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
-
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
-
K
D
D
P
D
A
V
E
---
L
R
E
V
R
G
E
------
I
E
F
K
N
V
W
F
S
Y
D
--
K
K
--
K
--
P
---
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
--
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
--------
Y
G
-
N
-
P
---
G
---
A
T
D
E
E
I
K
E
A
A
-
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
-
Y
------
3
PsiBlast_PDB
88.26
44%
-106
- C1 -
4Q4H
-
Y288_THEMA
B:
[15-591]
----------------
K
P
AL
K
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
F
D
L
--
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
---------
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
-
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
-
K
D
D
P
D
A
V
E
---
L
R
E
V
R
G
E
------
I
E
F
K
N
V
W
F
S
Y
D
--
K
K
--
K
--
P
---
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
--
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
--------
Y
G
-
N
-
P
---
G
---
A
T
D
E
E
I
K
E
A
A
-
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
-
Y
------
122
Fugue
74.63
34%
-96
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
------
D
R
S
V
--
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-
V
---
I
D
R
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
P
G-
R
E
--
V
--
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
G
-----
102
HHSearch
74.54
34%
-97
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
------
R
S
V
--
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-------
V
I
D
R
A
T
G
---
D
L
E
F
R
N
V
T
F
T
Y
P
--
G
R
E-
V
--
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
-
T
E--
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
G
-----
8
PsiBlast_PDB
74.14
33%
-100
- C1 -
3B60
2
MSBA_SALTY
A:
[11-580]
------------------------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
--------
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
SV
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-
V
---
I
D
R
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
---
P
G
--
R
EV
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
------
23
PsiBlast_CBE
73.88
33%
-100
- C1 -
3B60
2
MSBA_SALTY
B:
[11-580]
------------------------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
--------
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
SV
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-
V
---
I
D
R
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
---
P
G
--
R
EV
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
------
22
PsiBlast_CBE
73.75
33%
-100
- C1 -
3B60
2
MSBA_SALTY
C:
[11-580]
------------------------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
--------
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
SV
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-
V
---
I
D
R
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
---
P
G
--
R
EV
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
------
21
PsiBlast_CBE
73.69
33%
-100
- C1 -
3B60
2
MSBA_SALTY
D:
[11-580]
------------------------
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
--------
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
SV
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
---------
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
-
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
-
K
D
E
G
K
R
-
V
---
I
D
R
A
T
G
D
------
L
E
F
R
N
V
T
F
T
Y
---
P
G
--
R
EV
P
---
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
--
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
--------
Y
A
-
R
T
E
---
E
---
Y
S
R
E
Q
I
E
E
A
A
-
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
-
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
-
F
------
9
PsiBlast_PDB
73.53
33%
-100
- C1 -
2HYD
3
Y1866_STAAM
A:
[4-576]
----------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
----
I
D
G
V
I
N
N
H
A
L
T
T
D
E
--
K
V
H
H
L
T
I
A
I
----
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
-
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
-
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
A
-
Q
---
P
I
E
I
--
K
Q
G
---
R
I
D
I
D
H
V
S
F
Q
Y
N
--
D
N
--
E
A-
P
---
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
--
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
--------
L
G
-
R
-
P
---
T
---
A
T
D
E
E
V
V
E
A
A
-
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
--------
10
PsiBlast_PDB
73.25
33%
-101
- C1 -
2ONJ
4
Y1866_STAAM
A:
[4-576]
----------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
----
I
D
G
V
I
N
N
H
A
L
T
T
D
E
--
K
V
H
H
L
T
I
A
I
----
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
-
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
-
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
A
-
Q
---
P
I
E
I
--
K
Q
G
---
R
I
D
I
D
H
V
S
F
Q
Y
N
--
D
N
--
E
A-
P
---
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
--
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
--------
L
G
-
R
-
P
---
T
---
A
T
D
E
E
V
V
E
A
A
-
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
--------
31
PsiBlast_CBE
73.24
33%
-101
- C1 -
2HYD
3
Y1866_STAAM
B:
[4-576]
----------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
----
I
D
G
V
I
N
N
H
A
L
T
T
D
E
--
K
V
H
H
L
T
I
A
I
----
G
I
A
L
F
IFVIVRPPI
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
-
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
-
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
A
-
Q
---
P
I
E
I
--
K
Q
G
---
R
I
D
I
D
H
V
S
F
Q
Y
N
--
D
N
--
E
A-
P
---
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
--
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
--------
L
G
-
R
-
P
---
T
---
A
T
D
E
E
V
V
E
A
A
-
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
--------
30
PsiBlast_CBE
72.81
33%
-102
- C1 -
2ONJ
4
Y1866_STAAM
B:
[4-576]
----------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
----
I
D
G
V
I
N
N
H
A
L
T
T
D
E
--
K
V
H
H
L
T
I
A
I
----
G
I
A
L
F
IFVIVRPPI
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
-
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
-
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
A
-
Q
---
P
I
E
I
--
K
Q
G
---
R
I
D
I
D
H
V
S
F
Q
Y
N
--
D
N
--
E
A-
P
---
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
--
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
--------
L
G
-
R
-
P
---
T
---
A
T
D
E
E
V
V
E
A
A
-
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
-
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
--------
19
PsiBlast_PDB
72.72
31%
-99
* C1 *
4F4C
-
PGP1_CAEEL
A:
[163-708]
---------------------------------------------------------------------------------------------------------------------------
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
-
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
-
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
-
I
D
S
S
S
K
-
A
---
G
R
K
D
M
K
I
K
G
---
D
I
T
V
E
N
V
H
F
T
Y
P
SR
P
D
--
V
--
P
---
I
L
R
G
-
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
--
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
-
N
C
T
I
E
E
N
I
S
--------
L
G
-
K
-
E
---
G
---
I
T
R
E
E
M
V
A
A
C
-
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
--
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
-
A
-
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
---
15
PsiBlast_PDB
72.65
30%
-101
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[9-574]
----------------------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
---
Y
S
D
N
--
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
---------
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
----
P
K
L
P
F
-
N
---
E
G
V
I
L
N
E
K
S
FQG
A
L
E
F
K
N
V
H
F
A
Y
P
AR
P
E
--
V
--
P
---
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
--
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
--------
Y
G
-
A
-
D
DPS
S
---
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
-
S
K
P
--
N
G
-----------------
16
PsiBlast_PDB
72.30
30%
-99
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[9-572]
----------------------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
---
Y
S
D
N
--
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
---------
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
----
P
K
L
P
F
-
N
---
E
G
V
I
L
N
E
K
S
FQG
A
L
E
F
K
N
V
H
F
A
Y
P
AR
P
E
--
V
--
P
---
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
--
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
--------
Y
G
-
A
-
D
DPS
S
---
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
-
S
K
P
---------------------
104
HHSearch
70.71
28%
-98
- C1 -
3WMG
6
?
A:
[14-598]
--------------------------
A
R
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
----
I
E
G
E
--
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
---------
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
-
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
-
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
-
Y
R
R
P
D
P
-
G
A
E
V
V
T
Q
P
L
V
L
K
Q
---
G
I
V
F
E
N
V
H
F
R
Y
P
--
T
R
MN
V
--
E
---
V
L
R
G
-
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
--
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
--------
Y
G
-
K
-
R
---
D
---
A
T
D
E
E
V
I
Q
A
L
-
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
-
A
-
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
-
L
A
S
----
14
PsiBlast_PDB
70.18
30%
-97
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[9-567]
----------------------------
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
---
Y
S
D
N
--
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
---------
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
----
P
K
L
P
F
-
N
---
E
G
V
I
L
N
E
K
S
FQG
A
L
E
F
K
N
V
H
F
A
Y
P
AR
P
E
--
V
--
P
---
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
--
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
--------
Y
G
-
A
-
D
DPS
S
---
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------
103
HHSearch
69.75
29%
-94
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
-------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
---
Y
S
D
N
--
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
---------
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
-
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
-
L
P
F
N
E
G
-
V
---
I
L
N
E
K
S
F
Q
G
---
A
L
E
F
K
N
V
H
F
A
Y
P
--
A
R
PE
V
--
P
---
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
--
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
--------
Y
G
-
A
-
D
---
D
PSS
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
-
S
-
K
P--------------------
13
PsiBlast_PDB
67.87
30%
-96
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[35-598]
----------------
L
P
--
E
A
R
K
-----
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
D
---
Y
S
D
N
--
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
---------
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
----
P
K
L
P
F
-
N
---
E
G
V
I
L
N
E
K
S
FQG
A
L
E
F
K
N
V
H
F
A
Y
P
AR
P
E
--
V
--
P
---
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
--
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
--------
Y
G
-
A
-
D
DPS
S
---
V
T
A
E
E
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------
59
PsiBlast_CBE
56.51
42%
-116
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
57
PsiBlast_CBE
56.49
42%
-119
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
58
PsiBlast_CBE
56.08
42%
-115
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
54
PsiBlast_CBE
55.82
42%
-113
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
45
PsiBlast_CBE
55.53
42%
-117
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
33
PsiBlast_CBE
55.49
44%
-102
- C1 -
3NHB
3
A:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
-
V
K
D
L
P
G
-----
A
G
P
L
R
F
Q
K
G
---
R
I
E
F
E
N
V
H
F
S
Y
A
--
D
---
R
--
E
---
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
--
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
--------
Y
G
-
R
-
V
---
T
---
A
G
N
D
E
V
E
A
A
A
-
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
-
S
-
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--------
35
PsiBlast_CBE
55.48
44%
-97
- C1 -
3NH9
3
A:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
-
V
K
D
L
P
G
-----
A
G
P
L
R
F
Q
K
G
---
R
I
E
F
E
N
V
H
F
S
Y
A
--
D
G
--
R
--
E
---
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
--
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
--------
Y
G
-
R
-
V
---
T
---
A
G
N
D
E
V
E
A
A
A
-
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
-
S
-
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--------
56
PsiBlast_CBE
54.98
42%
-114
- C1 -
1XEF
3
D:
[2-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
38
PsiBlast_CBE
54.89
43%
-112
- C1 -
2PMK
1
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
---
D
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
34
PsiBlast_CBE
54.89
44%
-99
- C1 -
3NHA
4
A:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
M
F
D
L
L
K
E
E
T
E
-
V
K
D
L
P
G
-----
A
G
P
L
R
F
Q
K
G
---
R
I
E
F
E
N
V
H
F
S
Y
A
--
D
---
R
--
E
---
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
--
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
--------
Y
G
-
R
-
V
---
T
---
A
G
N
D
E
V
E
A
A
A
-
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
-
S
-
R
--
G
G
V
Y
A
D
M
W
Q
L
Q
--------
51
PsiBlast_CBE
54.79
42%
-120
- C1 -
2FGJ
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
42
PsiBlast_CBE
54.53
42%
-119
- C1 -
2FGK
2
D:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
40
PsiBlast_CBE
54.39
43%
-115
- C1 -
2FF7
1
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
55
PsiBlast_CBE
54.31
42%
-114
- C1 -
2FFA
2
A:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
44
PsiBlast_CBE
54.19
42%
-119
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
43
PsiBlast_CBE
53.96
42%
-116
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
52
PsiBlast_CBE
53.32
42%
-112
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
39
PsiBlast_CBE
53.06
43%
-113
- C1 -
3B5J
1
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
---
D
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
53
PsiBlast_CBE
53.05
42%
-113
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
--
P
D
--
S
--
P
---
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
--
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
--------
L
A
-
N
-
P
---
G
---
M
S
V
E
K
V
I
Y
A
A
-
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
-
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
--------
75
PsiBlast_CBE
49.36
35%
-107
- C1 -
2IXF
5
TAP1_RAT
A:
[17-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
---
P
N
--
H
--
P
NVQ
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
--
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
--------
Y
G
L
T
-
R
---
T
---
P
T
M
E
E
I
T
A
V
A
-
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-
E
-
R
--
G
G
C
Y
R
S
M
------------
74
PsiBlast_CBE
48.73
35%
-107
- C1 -
2IXF
4
TAP1_RAT
B:
[17-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
---
P
N
--
H
--
P
NVQ
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
--
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
--------
Y
G
L
T
-
R
---
T
---
P
T
M
E
E
I
T
A
V
A
-
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-
E
-
R
--
G
G
C
Y
R
S
M
------------
60
PsiBlast_CBE
47.97
42%
-110
- C1 -
5DGX
1
?
A:
[30-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
H
--
K
---
V
L
S
G
-
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
--
T
R
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
-
D
D
T
V
Y
N
N
I
A
--------
F
G
---
E
-------
V
S
E
E
E
V
I
D
A
L
-
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
--
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
-
E
-
Q
--
G
G
L
Y
T
R
L
Y
Q
S
---------
109
HHSearch
46.93
39%
-106
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
D
--
D
S
--
E
--
Q
---
I
L
R
D
-
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
--
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
--------
Y
G
-
L
-
E
---
G
D--
Y
T
D
E
D
L
W
Q
V
L
-
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
-
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
-
L
T
V
G
---
64
PsiBlast_CBE
45.16
39%
-102
- C1 -
1MV5
3
LMRA_LACLA
A:
[6-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
D
--
D
S
--
E
--
Q
---
I
L
R
D
-
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
--
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
--------
Y
G
-
L
-
E
---
G
---
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
-
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
-
L
T
V
G
---
81
PsiBlast_CBE
37.73
31%
-100
- C1 -
3C41
3
?
J:
[18-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
LK
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
LAPMKVRK
W
P
-
R
-
E
---
K
---
A
E
-------
A
-
K
A
M
E
L
L
D
K
V
-----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N-
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
-----------------------