@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0913: (2016-03-19 )
LSIKETALPKVQTKLFINGKWTDGDNKETKDIVNPANGDVIAKIAQAGPSETKKAIKAAKDAFPDWAKMELADRVKLLHKIADLMEEKADTLAKIMTLEQGKPLKESKGEVLTGVENFRFAAEEARRLYGETIPAPNNHAFIVKKQPIGVVAAITPWNFPGGMVTRKLAPALATGNTIVLKPSGDTPLSALAIFEIFEEAGLPKGVANIVMGSSKEIGETLTDSDDVRKLTFTGSTKVGQTLFKQSADTLKKISLELGGHAPFIVFDDANLDAAVNDLVAAKFRNNGQVCVSPNRIFVAKEIKEKFTKALVAKVEQLKVGNGLDDVNVGPLIREDAIDKIDKQLKNATEKGAKVLTGGGRLTGSDYDKGNFYKPTVLDNVTRKMDIFYEETFGPVIPLITFETEDEAIEMANDSEFGLASYFYTKDLARVEKVGAALEYGMVGANEIAISNPETPFGGVKHSGFGRENGHYGMEEYIQVKFINLKYRD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.--..-..-.-.140.......150.......160.......170.......180.......190.......200.......210.---.---.....220.......230.......240.......250.......260.......270.......280.......290.......300.......310....-....320..-.-....330.......340.......350.......360.......-370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LSIKETALPK
V
Q
T
K
L
F
I
N
G
K
WTDGDNK
E
T
K
DIVNPAN
G
D
V
I
A
K
I
A
QAG
P
S
E
T
K
K
A
I
K
A
A
K
DAFP
D
W
A
K
M
E
L
A
D
R
V
K
L
L
H
K
I
A
D
L
M
E
E
K
A
D
T
L
A
K
I
M
T
LEQGKPLKESKG
E
V
LT
G
V
E
N
F
R
F
A
A
E
E
A
R
R
L
YGETI--PA-PN-N-
H
A
F
I
V
K
KQPI
G
V
V
A
A
ITPWNFPG
G
M
V
T
R
K
LAPALATG
N
T
I
V
L
KPSGDT
P
L
S
A
L
A
I
F
E
I
F
E
EAGLP
K
G
V
A
N
I
VMGS---
S
---
K
E
IGETLTDSDD
V
R
K
L
T
FTGST
K
V
G
Q
T
L
F
K
Q
S
A
D
T
L
K
K
I
S
LELGGHA
P
F
I
V
F
DDAN
L
D
A
A
V
N
D
L
V
A
A
K
FRNNG
Q
V
C
VSP
N
R
I
F
V
A
K
E
I
K
E
K
F
T
K
A
L
V
-
A
K
V
E
-
Q
L
KVGNGLD-D-VNVGPL
I
R
E
D
A
I
D
K
I
D
K
Q
L
K
N
A
T
EKG
A
K
V
LTGGGRLTGSDYDKG-NFYK
P
T
V
L
D
N
V
T
R
K
M
D
I
F
Y
EETFG
P
V
I
P
L
I
T
FETED
E
A
IEMANDSEFG
L
A
S
Y
F
Y
T
K
D
L
A
R
V
E
K
V
G
A
A
L
E
Y
GMVGA
N
E
I
AISNPETPFGGVKHSGFGRENGHY
G
M
E
E
Y
I
Q
V
K
F
I
N
L
K
YRD
26
PsiBlast_CBE
99.10
50%
-61
- C4 -
3EK1
2
?
F:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
30
PsiBlast_CBE
98.96
50%
-60
- C4 -
3EK1
2
?
B:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
29
PsiBlast_CBE
98.92
50%
-61
- C4 -
3EK1
2
?
C:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
2
PsiBlast_PDB
98.79
50%
-60
- C4 -
3EK1
2
?
A:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
27
PsiBlast_CBE
98.78
50%
-60
- C4 -
3EK1
2
?
E:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
28
PsiBlast_CBE
98.48
50%
-60
- C4 -
3EK1
2
?
D:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
25
PsiBlast_CBE
98.48
50%
-59
- C4 -
3EK1
2
?
G:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
24
PsiBlast_CBE
98.42
50%
-60
- C4 -
3EK1
2
?
H:
[23-503]
L
A
L
K
D
P
S
L
L
K
S
Q
C
--
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
-
P
Q
-
N
G
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
L
G
G
L
-------
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
121
HHSearch
97.71
51%
-60
- C4 -
3EK1
2
?
A:
[31-503]
----------
L
K
S
Q
C
L
V
N
G
R
W
I
D
A
A
D
G
T
T
I
K
V
T
N
P
A
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
P
L
A
E
A
R
G
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
G
D
T
I
--
P
A
P
Q
N
-
G
-
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
G
V
L
A
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
---
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
P
T
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
-
A
K
V
K
-
E
L
K
V
G
N
G
T
E
P
G
-
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
A
K
L
I
T
G
G
K
E
------
L
G
G
-
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
N
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
-
22
PsiBlast_CBE
97.26
49%
-58
- C4 -
3JZ4
1
GABD_ECOLI
B:
[9-479]
-----------
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
--
P
G
-
H
Q
A
D
-
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
---
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
-
Q
A
M
S
-
K
L
H
I
G
D
G
L
D
-
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
----
K
A
H
E
R
G
G
-
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
----
21
PsiBlast_CBE
97.22
49%
-61
- C4 -
3JZ4
1
GABD_ECOLI
D:
[9-479]
-----------
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
--
P
G
-
H
Q
A
D
-
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
---
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
-
Q
A
M
S
-
K
L
H
I
G
D
G
L
D
-
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
----
K
A
H
E
R
G
G
-
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
----
131
HHSearch
97.04
49%
-58
- C4 -
3JZ4
1
GABD_ECOLI
A:
[1-480]
---
K
L
N
D
S
N
L
F
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
--
P
G
H
Q
A
-
D
-
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
---
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
-
Q
A
M
S
-
K
L
H
I
G
D
G
L
D
N
G
-
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
K
A
H
----
E
R
G
G
-
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
G
---
23
PsiBlast_CBE
96.84
49%
-60
- C4 -
3JZ4
1
GABD_ECOLI
A:
[9-479]
-----------
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
--
P
G
-
H
Q
A
D
-
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
---
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
-
Q
A
M
S
-
K
L
H
I
G
D
G
L
D
-
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
----
K
A
H
E
R
G
G
-
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
----
1
PsiBlast_PDB
96.65
49%
-61
- C4 -
3JZ4
1
GABD_ECOLI
C:
[9-479]
-----------
R
Q
Q
A
L
I
N
G
E
W
L
D
A
N
N
G
E
A
I
D
V
T
N
P
A
N
G
D
K
L
G
S
V
P
K
M
G
A
D
E
T
R
A
A
I
D
A
A
N
R
A
L
P
A
W
R
A
L
T
A
K
E
R
A
T
I
L
R
N
W
F
N
L
M
M
E
H
Q
D
D
L
A
R
L
M
T
L
E
Q
G
K
P
L
A
E
A
K
G
E
I
S
Y
A
A
S
F
I
E
W
F
A
E
E
G
K
R
I
Y
G
D
T
I
--
P
G
-
H
Q
A
D
-
K
R
L
I
V
I
K
Q
P
I
G
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
G
P
A
L
A
A
G
C
T
M
V
L
K
P
A
S
Q
T
P
F
S
A
L
A
L
A
E
L
A
I
R
A
G
V
P
A
G
V
F
N
V
V
T
G
S
---
A
---
G
A
V
G
N
E
L
T
S
N
P
L
V
R
K
L
S
F
T
G
S
T
E
I
G
R
Q
L
M
E
Q
C
A
K
D
I
K
K
V
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
K
A
V
E
G
A
L
A
S
K
F
R
N
A
G
Q
T
C
V
C
A
N
R
L
Y
V
Q
D
G
V
Y
D
R
F
A
E
K
L
Q
-
Q
A
M
S
-
K
L
H
I
G
D
G
L
D
-
N
G
V
T
I
G
P
L
I
D
E
K
A
V
A
K
V
E
E
H
I
A
D
A
L
E
K
G
A
R
V
V
C
G
G
----
K
A
H
E
R
G
G
-
N
F
F
Q
P
T
I
L
V
D
V
P
A
N
A
K
V
S
K
E
E
T
F
G
P
L
A
P
L
F
R
F
K
D
E
A
D
V
I
A
Q
A
N
D
T
E
F
G
L
A
A
Y
F
Y
A
R
D
L
S
R
V
F
R
V
G
E
A
L
E
Y
G
I
V
G
I
N
T
G
I
I
S
N
E
V
A
P
F
G
G
I
K
A
S
G
L
G
R
E
G
S
K
Y
G
I
E
D
Y
L
E
I
K
Y
M
C
I
----
130
HHSearch
95.39
46%
-54
- C4 -
2W8N
8
SSDH_HUMAN
A:
[9-485]
--------
A
L
L
R
T
D
S
F
V
G
G
R
W
L
P
--
A
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
--
H
T
P
A
K
-
D
-
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
---
R
KN
A
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
-
E
A
M
K
K
N
L
R
V
G
N
G
F
E
E
G
-
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
H
----
Q
L
G
K
-
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
---
5
PsiBlast_PDB
95.17
46%
-55
- C4 -
2W8P
10
SSDH_HUMAN
A:
[11-482]
----------
L
R
T
D
S
F
V
G
G
R
W
L
P
A
--
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
-
K
D
-
R
-
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
RKN
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
-
N
L
R
V
G
N
G
F
E
-
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
-----
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
------
7
PsiBlast_PDB
94.85
46%
-58
- C4 -
2W8R
12
SSDH_HUMAN
A:
[11-482]
----------
L
R
T
D
S
F
V
G
G
R
W
L
P
A
--
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
-
K
D
-
R
-
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
RKN
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
-
N
L
R
V
G
N
G
F
E
-
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
-----
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
------
6
PsiBlast_PDB
94.72
46%
-55
- C4 -
2W8Q
11
SSDH_HUMAN
A:
[11-482]
----------
L
R
T
D
S
F
V
G
G
R
W
L
P
A
--
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
-
K
D
-
R
-
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
RKN
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
A
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
-
N
L
R
V
G
N
G
F
E
-
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
-----
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
------
3
PsiBlast_PDB
94.28
46%
-56
- C4 -
2W8N
8
SSDH_HUMAN
A:
[11-482]
----------
L
R
T
D
S
F
V
G
G
R
W
L
P
A
--
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
-
K
D
-
R
-
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
RKN
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
-
N
L
R
V
G
N
G
F
E
-
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
-----
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
C
T
H
E
E
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
------
4
PsiBlast_PDB
93.28
46%
-58
- C4 -
2W8O
10
SSDH_HUMAN
A:
[11-482]
----------
L
R
T
D
S
F
V
G
G
R
W
L
P
A
--
A
A
T
F
P
V
Q
D
P
A
S
G
A
A
L
G
M
V
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
K
P
L
K
E
A
H
G
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
Y
G
D
I
I
H
T
P
A
-
K
D
-
R
-
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
A
E
L
A
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
RKN
A
---
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
I
L
L
H
H
A
A
N
S
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
A
M
K
K
-
N
L
R
V
G
N
G
F
E
-
E
G
T
T
Q
G
P
L
I
N
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
T
G
G
K
R
-----
H
Q
L
G
K
N
F
F
E
P
T
L
L
C
N
V
T
Q
D
M
L
-----
T
F
G
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
S
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
------