@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1014: (2016-03-20 )
LSKIKVEELTKIFGKKASKASSLLSQGKSKTDILKETGATIGVNKASFSVEEGEIFVIMGLSGSGKSTLVRLLNRLIEPTSGKIWLDGKELSSLNKKELLEVRRKSMSMVFQNFGLFPNRTINRNVEYGLEIQGMDKEEREKNAAESLALVGLAGYGDQYPSQLSGGMQQRVGLARALANNPDILLMDEAFSALDPLNRKDMQDQLLDLQDKMKKTIIFITHDLDEALRIGDHIMIMRDGSVVQTGSPEEILAHPANEYVEKFIEDVDRSKVYTASNVMIRPEIVNFEKDGPRVALKRMREAGTSSVFVVKRNRELVGIVHAAEVSKLVKENITSLETALHRDVPTTGLDTPLAEIMDTISTTTIPIAVTEDGKLKGIIIRGSVLAALSGNEVNVNA
Atome Classification :
(37 SA)
-.........10........20........30.......-.----40-.....-...50........60........70........80........90.......---------.100.......110.......120....-...-130..---......140.......150.-.....-.160.......170.......180.......190.......200.......210..---.---....220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-LSK
I
K
V
E
E
L
T
K
I
FGKK
A
S
K
A
S
S
L
L
S
QGKS
K
T
D
I
L
K
ETG-
A
----
T
I
-
G
VNKA-SFSVEEG
E
I
F
V
I
MGLSGS
G
K
S
T
L
V
R
L
L
N
R
LIEPTS
G
K
I
W
LD
G
K
E
L
SSL
N
K
K
E
---------
L
L
E
V
R
R
K
S
M
S
M
V
F
Q
NFGLFPNRTINRNV-EY
G
-
L
-
E
I
Q---GM
D
K
E
E
R
E
K
N
A
A
E
S
L
A
L
V
G
L-AGYGD-Q
Y
P
S
Q
L
SG
G
M
Q
Q
R
V
G
L
A
R
A
LANNP
D
I
L
L
M
D
E
A
F
S
ALDPL
N
R
K
D
M
Q
D
Q
L
L
D
L
Q
D
KMK---
K
---
T
I
I
F
I
THD
L
D
E
A
L
RIG
D
H
I
M
I
M
RDG
S
V
V
QTG
S
P
E
E
I
L
AH
P
A
N
E
Y
V
E
K
F
I
E
DVDRS
K
V
Y
TASN
V
M
IRPEIVNFEKDG
P
R
V
A
L
K
R
M
R
EAGT
S
S
V
F
V
V
KRN
R
E
L
V
G
I
V
H
A
A
E
V
S
K
L
V
K
E
N
I
T
S
L
E
T
A
L
HRDVPTTGLD
T
P
L
A
E
I
M
D
T
ISTT
T
I
P
I
A
VTEDG
K
L
K
G
I
I
IRG
S
V
L
A
ALSG
N
E
VNVNA
2
PsiBlast_PDB
86.58
40%
-93
- C1 -
3TUI
1
METN_ECOLI
C:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
86.36
31%
-84
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
--------------------
T
R
-
T
----
I
Q
-
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
------
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
----------------------------
3
PsiBlast_PDB
86.24
40%
-95
- C1 -
3TUZ
1
METN_ECOLI
C:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.51
40%
-94
- C1 -
3TUZ
1
METN_ECOLI
G:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
85.32
40%
-91
- C1 -
3TUI
1
METN_ECOLI
G:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
85.15
40%
-89
- C1 -
3TUI
1
METN_ECOLI
D:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
84.24
39%
-79
* C1 *
3TUI
1
METN_ECOLI
C:
[23-266]
--------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
GTRT
I
Q
-
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.07
40%
-102
- C1 -
3TUI
1
METN_ECOLI
H:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.58
40%
-91
- C1 -
3TUZ
1
METN_ECOLI
D:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.46
40%
-99
- C1 -
3TUZ
1
METN_ECOLI
H:
[31-265]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.95
40%
-86
- C1 -
3DHW
-
METN_ECOLI
C:
[8-242]
-------------------------------
T
K
V
F
H
Q
G
T
-
R
----
T
I
Q
A
L
N
N
V
-
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
---------
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
-
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
-
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
---
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.34
39%
-98
- C1 -
4YMW
-
?
J:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.08
39%
-95
- C1 -
4YMS
-
?
J:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
80.99
37%
-82
- C1 -
1Z47
1
?
A:
[15-249]
----------------------------
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
R
-
S
V
R
G
V
-
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
---------------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
F
G
-
L
-
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.76
37%
-94
- C1 -
1Z47
1
?
A:
[26-253]
--------------------------------------
G
-
G
----
A
R
-
S
V
R
G
V
-
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
---------------
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
F
G
-
L
-
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
---
S
N
V
W
T
---------------------------------------------------------------------------------------------------------------------------
115
Fugue
80.62
28%
-63
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
-----------------------
G
-
G
----
A
R
-
S
V
R
G
V
-
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
---------------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
F
G
-
L
-
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
Y
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
---
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
--------
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
-
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
---------------
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
6
PsiBlast_PDB
80.23
36%
-94
- C1 -
2IT1
-
?
A:
[8-234]
--------------------------------
N
I
V
K
K
F
G
-
N
----
F
T
-
A
L
N
N
I
-
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
P
K
D
---------------
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
-
A
F
P
-
L
-
E
L
R
---
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
-
D
K
L
L
N
-
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
---
I
---
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
-------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
80.19
39%
-95
- C1 -
4YMU
2
?
A:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.92
39%
-93
- C1 -
4YMU
2
?
J:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
79.53
39%
-95
- C1 -
4YMV
1
?
A:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.34
39%
-98
- C1 -
4YMV
1
?
J:
[6-239]
--------------------------------
D
V
Y
K
N
F
G
-
S
----
L
E
-
V
L
K
G
V
-
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-
G
K
V
N
---------
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
-
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
K
D
-
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
----------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
74.96
32%
-89
- C1 -
1B0U
4
HISP_SALTY
A:
[11-254]
--------------------------------
D
L
H
K
R
Y
G
-
G
----
H
E
-
V
L
K
G
V
-
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
GQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
-
Q
V
L
---
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
-
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
----
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
---
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.06
40%
-96
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[20-239]
-------------------------------------------------
L
N
D
I
-
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-----------
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
G
-
L
G
N
G
K
---
G
R
T
A
Q
E
R
Q
R
I
E
A
-
M
L
E
L
T
G
I
-
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.95
33%
-91
- C1 -
2D62
7
?
A:
[11-243]
--------------------------------
N
I
W
K
R
F
G
-
D
----
V
T
-
A
V
K
D
L
-
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
A
D
P
E
K
G
V
---------
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
-
A
F
P
-
L
-
K
L
R
---
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
-
T
E
L
L
N
-
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
---
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
-------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
73.69
36%
-84
- C1 -
2OLK
2
?
B:
[30-262]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.47
36%
-81
- C1 -
3C4J
3
?
A:
[30-262]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
72.31
36%
-86
- C1 -
3C4J
4
?
B:
[30-262]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
72.10
36%
-79
- C1 -
2OLK
1
?
D:
[30-262]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.02
36%
-81
- C1 -
3C41
3
?
K:
[9-241]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.56
40%
-97
- C1 -
4U00
3
?
A:
[24-241]
------------------------------------------------------
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
---------
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
-
R
V
R
---
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
Q
A
R
-
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
---
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
----------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.53
40%
-98
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[20-244]
-------------------------------------------------
L
N
D
I
-
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-----------
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
G
-
L
G
N
G
K
---
G
R
T
A
Q
E
R
Q
R
I
E
A
-
M
L
E
L
T
G
I
-
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
-------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
71.51
36%
-80
- C1 -
3C41
3
?
J:
[9-241]
----------------------------------
L
K
K
S
F
-
G
----
S
L
-
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
--
K
D
T
---------
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
-
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
---
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
----------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
68.27
40%
-87
- C1 -
3TIF
6
Y796_METJA
B:
[25-223]
------------------------------------------------------
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---------
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
-
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
-
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
---
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
67.38
40%
-88
- C1 -
1L2T
4
Y796_METJA
B:
[25-223]
------------------------------------------------------
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---------
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
-
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
-
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
---
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
67.20
40%
-86
- C1 -
3TIF
7
Y796_METJA
A:
[25-223]
------------------------------------------------------
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---------
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
-
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
-
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
---
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
67.09
40%
-86
- C1 -
1L2T
4
Y796_METJA
A:
[25-223]
------------------------------------------------------
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
---------
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
-
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
-
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
---
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
66.53
37%
-80
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-247]
---------------------------
A
L
H
I
G
H
L
S
K
S
F
Q
-
N
----
T
P
-
V
L
N
D
I
-
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-----------
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
-
A
Y
G
-
L
-
G
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
E
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
---
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
----------------------------------------------------------------------------------------------------------------------------------