@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1448: (2016-03-24 )
MTKTLVFGHKNPDTDTICSAISYAELKKAQGADIEAVRLGELNSETAFVLDYFQVTAPRLVQTVANEVSEVALVDHNERQQSVDDIDDVTVTAVVDHHRIANFETSDPLYYRAEPVGCTTTILLKMFRENEVEVSKTVAGLMLSAIISDTLLFQSPTCTEEDKVAAQKLAQIADVDIQSYGMEMLKAGADVSKKTVAELLLDAKEFNMNDNKVEIAQINVVDVNDVLSRRAEVEALMTQNIVDKGLDLYLFVITNILTNDSVGIAIGSKTAVVEEAYGVKFVENQAPLKGVVSRKKQVVPILTDTFAK
Atome Classification :
(20 SA)
.........10........20.....-...30.........40........50........60..-....-..70.........80........90........100.......110.......120.......130--------.......140.......150.......160.......170...-.-...180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
K
T
L
V
FGHKNP
D
T
D
T
I
C
S
A
I
S
Y
A
E
L
-
K
KAQ-GAD
I
E
A
V
R
LGELNSE
T
A
F
V
L
D
Y
F
QV
T
A
P
R
L
V
Q
T
-
V
A
N
E
-
V
S
E
-
V
A
L
VD
H
N
E
R
QQSVDDIDD
V
T
V
T
A
V
VDHHRIANFETSDP
L
Y
Y
RAEPVG
C
T
T
T
I
L
L
K
M
F
R
ENE
V
--------
E
V
S
K
T
V
A
G
L
M
L
S
A
I
I
S
D
T
LLFQSPTCT
E
E
D
K
V
A
A
Q
K
L
A
Q
I
A
DV-
D
-
I
Q
S
Y
G
M
E
M
L
K
AGAD
V
S
K
K
T
V
A
E
L
L
-
L
D
A
K
EFNMNDN
K
V
E
I
A
Q
I
N
V
V
D
V
N
D
V
L
S
R
R
A
E
V
E
A
L
M
T
Q
N
I
V
D
KG
L
D
L
Y
L
F
V
I
T
N
I
LTNDS
V
G
I
A
IGSK
T
A
V
V
E
E
AYG
V
K
F
VENQA
P
L
K
G
V
V
SRKK
Q
V
V
P
I
LTDTFAK
1
PsiBlast_PDB
92.57
63%
-104
- C5 -
1WPM
3
PPAC_BACSU
A:
[2-308]
-
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
-
2
PsiBlast_PDB
92.23
63%
-104
- C5 -
2HAW
9
PPAC_BACSU
A:
[2-308]
-
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
-
18
PsiBlast_CBE
91.78
63%
-103
- C5 -
1WPM
4
PPAC_BACSU
B:
[1-308]
M
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
-
17
PsiBlast_CBE
91.66
63%
-103
- C5 -
2HAW
12
PPAC_BACSU
B:
[1-308]
M
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
-
25
HHSearch
91.30
63%
-100
- C5 -
2HAW
9
PPAC_BACSU
A:
[2-308]
-
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
A
A
N
E
V
--
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
-
3
PsiBlast_PDB
90.50
63%
-42
- C- -
2IW4
8
PPAC_BACSU
A:
[2-309]
-
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
Q
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
E
4
PsiBlast_PDB
90.21
62%
-113
- C5 -
1K23
2
PPAC_BACSU
A:
[3-307]
--
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
--
21
PsiBlast_CBE
89.91
52%
-108
- C5 -
1WPP
6
PPAC_STRGC
B:
[2-309]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
Y
A
F
A
Y
L
A
R
E
A
Y
-
G
L
D
T
E
A
V
A
L
G
E
P
N
E
E
T
A
F
V
L
D
Y
F
G
V
A
A
P
R
V
I
T
S
-
A
K
A
E
-
G
A
E
Q
V
I
L
T
D
H
N
E
F
Q
Q
S
V
A
D
I
A
E
V
E
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
S
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
H
G
V
--------
A
V
P
K
E
I
A
G
L
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
P
T
D
K
V
I
A
P
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
S
A
E
E
L
I
D
I
D
A
K
T
F
E
L
N
G
N
N
V
R
V
A
Q
V
N
T
V
D
I
A
E
V
L
E
R
Q
A
E
I
E
A
A
I
E
K
A
I
A
D
N
G
Y
S
D
F
V
L
M
I
T
D
I
I
N
S
N
S
E
I
L
A
I
G
S
N
M
D
K
V
E
A
A
F
N
F
V
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
--
35
Fugue
89.73
51%
-95
- C5 -
1K20
5
PPAC_STRGC
A:
[1-310]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
Y
A
F
A
Y
L
-
A
R
E
A
Y
G
L
D
T
E
A
V
A
L
G
E
P
N
E
E
T
A
F
V
L
D
Y
F
G
V
A
A
P
R
V
I
T
S
-
A
K
A
E
G
A
E
Q
-
V
I
L
T
D
H
N
E
F
Q
Q
S
V
A
D
I
A
E
V
E
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
H
S
V
--------
A
V
S
K
E
I
A
G
L
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
P
T
D
K
A
I
A
P
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
S
A
E
E
L
I
D
I
D
A
K
T
F
E
L
N
G
N
N
V
R
V
A
Q
V
N
T
V
D
I
A
E
V
L
E
R
Q
A
E
I
E
A
A
I
E
K
A
I
A
D
N
G
Y
S
D
F
V
L
M
I
T
D
I
I
N
S
N
S
E
I
L
A
I
G
S
N
M
D
K
V
E
A
A
F
N
F
V
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
N
A
19
PsiBlast_CBE
89.70
63%
-41
- C- -
2IW4
11
PPAC_BACSU
B:
[1-309]
M
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
Q
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
A
D
L
S
K
K
T
V
E
E
L
I
S
L
D
A
K
E
F
T
L
G
S
K
K
V
E
I
A
Q
V
N
T
V
D
I
E
D
V
K
K
R
Q
A
E
L
E
A
V
I
S
K
V
V
A
E
K
N
L
D
L
F
L
L
V
I
T
D
I
L
E
N
D
S
L
A
L
A
I
G
N
E
A
A
K
V
E
K
A
F
N
V
T
L
E
N
N
T
A
L
L
K
G
V
V
S
R
K
K
Q
V
V
P
V
L
T
D
A
M
A
E
6
PsiBlast_PDB
89.57
52%
-106
- C5 -
1WPP
6
PPAC_STRGC
A:
[2-309]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
Y
A
F
A
Y
L
A
R
E
A
Y
-
G
L
D
T
E
A
V
A
L
G
E
P
N
E
E
T
A
F
V
L
D
Y
F
G
V
A
A
P
R
V
I
T
S
-
A
K
A
E
-
G
A
E
Q
V
I
L
T
D
H
N
E
F
Q
Q
S
V
A
D
I
A
E
V
E
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
S
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
H
G
V
--------
A
V
P
K
E
I
A
G
L
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
P
T
D
K
V
I
A
P
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
S
A
E
E
L
I
D
I
D
A
K
T
F
E
L
N
G
N
N
V
R
V
A
Q
V
N
T
V
D
I
A
E
V
L
E
R
Q
A
E
I
E
A
A
I
E
K
A
I
A
D
N
G
Y
S
D
F
V
L
M
I
T
D
I
I
N
S
N
S
E
I
L
A
I
G
S
N
M
D
K
V
E
A
A
F
N
F
V
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
--
7
PsiBlast_PDB
89.39
52%
-96
- C5 -
1K20
5
PPAC_STRGC
A:
[1-308]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
Y
A
F
A
Y
L
A
R
E
A
Y
-
G
L
D
T
E
A
V
A
L
G
E
P
N
E
E
T
A
F
V
L
D
Y
F
G
V
A
A
P
R
V
I
T
S
-
A
K
A
E
-
G
A
E
Q
V
I
L
T
D
H
N
E
F
Q
Q
S
V
A
D
I
A
E
V
E
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
H
S
V
--------
A
V
S
K
E
I
A
G
L
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
P
T
D
K
A
I
A
P
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
S
A
E
E
L
I
D
I
D
A
K
T
F
E
L
N
G
N
N
V
R
V
A
Q
V
N
T
V
D
I
A
E
V
L
E
R
Q
A
E
I
E
A
A
I
E
K
A
I
A
D
N
G
Y
S
D
F
V
L
M
I
T
D
I
I
N
S
N
S
E
I
L
A
I
G
S
N
M
D
K
V
E
A
A
F
N
F
V
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
--
22
PsiBlast_CBE
89.30
52%
-95
- C5 -
1K20
6
PPAC_STRGC
B:
[1-308]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
Y
A
F
A
Y
L
A
R
E
A
Y
-
G
L
D
T
E
A
V
A
L
G
E
P
N
E
E
T
A
F
V
L
D
Y
F
G
V
A
A
P
R
V
I
T
S
-
A
K
A
E
-
G
A
E
Q
V
I
L
T
D
H
N
E
F
Q
Q
S
V
A
D
I
A
E
V
E
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
H
S
V
--------
A
V
S
K
E
I
A
G
L
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
P
T
D
K
A
I
A
P
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
S
A
E
E
L
I
D
I
D
A
K
T
F
E
L
N
G
N
N
V
R
V
A
Q
V
N
T
V
D
I
A
E
V
L
E
R
Q
A
E
I
E
A
A
I
E
K
A
I
A
D
N
G
Y
S
D
F
V
L
M
I
T
D
I
I
N
S
N
S
E
I
L
A
I
G
S
N
M
D
K
V
E
A
A
F
N
F
V
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
--
5
PsiBlast_PDB
88.75
52%
-102
- C5 -
2ENX
5
PPAC_STRA5
A:
[1-308]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
V
A
F
A
Y
L
A
K
E
A
W
-
G
L
D
T
E
A
V
A
L
G
T
P
N
E
E
T
A
Y
V
L
D
Y
F
G
V
Q
A
P
R
V
V
E
S
-
A
K
A
E
G
V
E
T
-
V
I
L
T
D
H
N
E
F
Q
Q
S
I
S
D
I
K
D
V
T
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
N
G
V
--------
S
V
P
K
E
L
A
G
L
L
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
A
S
D
I
P
V
A
K
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
E
M
L
K
A
G
T
N
L
S
S
K
T
A
A
E
L
I
D
I
D
A
K
T
F
E
L
N
G
E
A
V
R
V
A
Q
V
N
T
V
D
I
N
D
I
L
A
R
Q
E
E
I
E
V
A
I
Q
E
A
I
V
T
E
G
Y
S
D
F
V
L
M
I
T
D
I
V
N
S
N
S
E
I
L
A
L
G
S
N
M
A
K
V
E
A
A
F
E
F
T
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
Y
--
20
PsiBlast_CBE
88.08
52%
-100
- C5 -
2ENX
5
PPAC_STRA5
B:
[1-308]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
V
A
F
A
Y
L
A
K
E
A
W
-
G
L
D
T
E
A
V
A
L
G
T
P
N
E
E
T
A
Y
V
L
D
Y
F
G
V
Q
A
P
R
V
V
E
S
-
A
K
A
E
G
V
E
T
-
V
I
L
T
D
H
N
E
F
Q
Q
S
I
S
D
I
K
D
V
T
V
Y
G
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
M
F
K
E
N
G
V
--------
S
V
P
K
E
L
A
G
L
L
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
A
S
D
I
P
V
A
K
E
L
A
E
L
A
G
V
-
N
-
L
E
E
Y
G
L
E
M
L
K
A
G
T
N
L
S
S
K
T
A
A
E
L
I
D
I
D
A
K
T
F
E
L
N
G
E
A
V
R
V
A
Q
V
N
T
V
D
I
N
D
I
L
A
R
Q
E
E
I
E
V
A
I
Q
E
A
I
V
T
E
G
Y
S
D
F
V
L
M
I
T
D
I
V
N
S
N
S
E
I
L
A
L
G
S
N
M
A
K
V
E
A
A
F
E
F
T
L
E
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
Y
--
8
PsiBlast_PDB
87.30
48%
-100
- C5 -
1I74
5
PPAC_STRMU
A:
[1-307]
-
S
K
I
L
V
F
G
H
Q
N
P
D
S
D
A
I
G
S
S
M
A
Y
A
Y
L
-
K
R
Q
L
-
G
V
D
A
Q
A
V
A
L
G
N
P
N
E
E
T
A
F
V
L
D
Y
F
G
I
Q
A
P
P
V
V
K
S
-
A
Q
A
E
G
A
K
Q
-
V
I
L
T
D
H
N
E
F
Q
Q
S
I
A
D
I
R
E
V
E
V
V
E
V
V
D
H
H
R
V
A
N
F
E
T
A
N
P
L
Y
M
R
L
E
P
V
G
S
A
S
S
I
V
Y
R
L
Y
K
E
N
G
V
--------
A
I
P
K
E
I
A
G
V
M
L
S
G
L
I
S
D
T
L
L
L
K
S
P
T
T
H
A
S
D
P
A
V
A
E
D
L
A
K
I
A
G
V
-
D
-
L
Q
E
Y
G
L
A
M
L
K
A
G
T
N
L
A
S
K
T
A
A
Q
L
V
D
I
D
A
K
T
F
E
L
N
G
S
Q
V
R
V
A
Q
V
N
T
V
D
I
N
E
V
L
E
R
Q
N
E
I
E
E
A
I
K
A
S
Q
A
A
N
G
Y
S
D
F
V
L
M
I
T
D
I
L
N
S
N
S
E
I
L
A
L
G
N
N
T
D
K
V
E
A
A
F
N
F
T
L
K
N
N
H
A
F
L
A
G
A
V
S
R
K
K
Q
V
V
P
Q
L
T
E
S
F
--
26
HHSearch
81.38
43%
-85
- C5 -
2EB0
2
PPAC_METJA
A:
[1-307]
--
M
R
Y
V
V
G
H
K
N
P
D
T
D
S
I
A
S
A
I
V
L
A
Y
F
-
L
D
C
Y
-
P
-----
A
R
L
G
D
I
N
P
E
T
E
F
V
L
R
K
F
G
V
M
E
P
E
L
I
E
S
--
A
K
G
--
K
E
-
I
I
L
V
D
H
S
E
K
S
Q
S
F
D
D
L
E
E
G
K
L
I
A
I
I
D
H
H
K
V
G
L
T
T
-
T
E
P
I
L
Y
Y
A
K
P
V
G
S
T
A
T
V
I
A
E
L
Y
F
K
D
A
I
DLIGGKK
K
E
L
K
P
D
L
A
G
L
L
L
S
A
I
I
S
D
T
V
L
F
K
S
P
T
T
T
D
L
D
K
E
M
A
K
K
L
A
E
I
A
G
I
-
S
N
I
E
E
F
G
M
E
I
L
K
A
K
S
V
V
G
K
L
K
P
E
E
I
I
N
M
D
F
K
N
F
D
F
N
G
K
K
V
G
I
G
Q
V
E
V
I
D
V
S
E
V
E
S
K
K
E
D
I
Y
K
L
L
E
E
K
L
K
N
E
G
Y
D
L
I
V
F
L
I
T
D
I
M
K
E
G
S
E
A
L
V
V
G
N
K
-
E
M
F
E
K
A
F
---
V
E
G
N
S
V
F
L
E
G
V
M
S
R
K
K
Q
V
V
P
P
L
E
R
A
Y
N
G
24
PsiBlast_CBE
81.12
41%
-95
- C5 -
2EB0
2
PPAC_METJA
B:
[4-305]
-----
V
V
G
H
K
N
P
D
T
D
S
I
A
S
A
I
V
L
A
Y
F
-------
L
D
C
Y
P
A
R
L
G
D
I
N
P
E
T
E
F
V
L
R
K
F
G
V
M
E
P
E
L
I
E
S
-
A
K
G
K
---
E
-
I
I
L
V
D
H
S
E
K
S
Q
S
F
D
D
L
E
E
G
K
L
I
A
I
I
D
H
H
K
V
G
-
L
T
T
T
E
P
I
L
Y
Y
A
K
P
V
G
S
T
A
T
V
I
A
E
L
Y
F
K
D
A
I
DLIGGKKK
E
L
K
P
D
L
A
G
L
L
L
S
A
I
I
S
D
T
V
L
F
K
S
P
T
T
T
D
L
D
K
E
M
A
K
K
L
A
E
I
A
G
I
S
N
-
I
E
E
F
G
M
E
I
L
K
A
K
S
V
V
G
K
L
K
P
E
E
I
I
N
M
D
F
K
N
F
D
F
N
G
K
K
V
G
I
G
Q
V
E
V
I
D
V
S
E
V
E
S
K
K
E
D
I
Y
K
L
L
E
E
K
L
K
N
E
G
Y
D
L
I
V
F
L
I
T
D
I
M
K
E
G
S
E
A
L
V
V
G
N
K
E
-
M
F
E
K
A
F
N
V
K
V
E
G
N
S
V
F
L
E
G
V
M
S
R
K
K
Q
V
V
P
P
L
E
R
A
Y
--
10
PsiBlast_PDB
80.87
41%
-94
- C5 -
2EB0
2
PPAC_METJA
A:
[4-305]
-----
V
V
G
H
K
N
P
D
T
D
S
I
A
S
A
I
V
L
A
Y
F
-------
L
D
C
Y
P
A
R
L
G
D
I
N
P
E
T
E
F
V
L
R
K
F
G
V
M
E
P
E
L
I
E
S
-
A
K
G
K
---
E
-
I
I
L
V
D
H
S
E
K
S
Q
S
F
D
D
L
E
E
G
K
L
I
A
I
I
D
H
H
K
V
G
-
L
T
T
T
E
P
I
L
Y
Y
A
K
P
V
G
S
T
A
T
V
I
A
E
L
Y
F
K
D
A
I
DLIGGKK
K
E
L
K
P
D
L
A
G
L
L
L
S
A
I
I
S
D
T
V
L
F
K
S
P
T
T
T
D
L
D
K
E
M
A
K
K
L
A
E
I
A
G
I
S
N
-
I
E
E
F
G
M
E
I
L
K
A
K
S
V
V
G
K
L
K
P
E
E
I
I
N
M
D
F
K
N
F
D
F
N
G
K
K
V
G
I
G
Q
V
E
V
I
D
V
S
E
V
E
S
K
K
E
D
I
Y
K
L
L
E
E
K
L
K
N
E
G
Y
D
L
I
V
F
L
I
T
D
I
M
K
E
G
S
E
A
L
V
V
G
N
K
E
-
M
F
E
K
A
F
---
V
E
G
N
S
V
F
L
E
G
V
M
S
R
K
K
Q
V
V
P
P
L
E
R
A
Y
--
23
PsiBlast_CBE
75.31
66%
-113
- C5 -
1WPN
2
PPAC_BACSU
B:
[2-188]
-
E
K
I
L
I
F
G
H
Q
N
P
D
T
D
T
I
C
S
A
I
A
Y
A
D
L
-
K
N
K
L
-
G
F
N
A
E
P
V
R
L
G
Q
V
N
G
E
T
Q
Y
A
L
D
Y
F
K
Q
E
S
P
R
L
V
E
T
-
A
A
N
E
-
V
N
G
-
V
I
L
V
D
H
N
E
R
Q
Q
S
I
K
D
I
E
E
V
Q
V
L
E
V
I
D
H
H
R
I
A
N
F
E
T
A
E
P
L
Y
Y
R
A
E
P
V
G
C
T
A
T
I
L
N
K
M
Y
K
E
N
N
V
--------
K
I
E
K
E
I
A
G
L
M
L
S
A
I
I
S
D
S
L
L
F
K
S
P
T
C
T
D
Q
D
V
A
A
A
K
E
L
A
E
I
A
G
V
-
D
-
A
E
E
Y
G
L
N
M
L
K
A
G
-------------------------------------------------------------------------------------------------------------------------