@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1450: (2016-03-24 )
MTKKSRFDQFGFQPFIGLAIDKLGFYEPTEVQQKLIPGILKGESIIGQSQTGTGKTHTFILPIINNVNPEKDAVQAVITAPSRELATQIYNEIRKVTKYSEKEIAVQLVIGGTDKQRAIDKLKKQPQIIVGTPGRINDLIREQALFVHTAKTLVIDEADMTLDMGFLNDVDHIAGKMPANLQMLVFSATIPQKLKPFLSKYMENPRYEHIQPKVAASKTVEHRIMATRSRNKLDLLKNVLVGSQPYLAIVFTNTKTTADEVANGLIERGLKVAKIHGDVNPRERKRTMKQIENLDYQYVVATDLAARGIDIQGISHVVNYELPDDLDFYIHRTGRTGRAGHSGIALTLFEPADEDRLNQLEKMGIEFKHVDWKNKEFVTLEDRNRRAKREAKRETADPREIGMRKKAKQKGKPNYKKKINYKMNEIKRRERRKKR
Atome Classification :
(34 SA)
.........10........20........30........40.--.-......50........60......--..---70-----.---..--------.....80........90........100.......110.-......120...-....130.......140.......150.......160.-......-170---....--...--.180.......190.......200.......210-.........220....---.-..230........240--.........250.......260.......270.......280.......290.......300.......310.......320..------.....330.......340.......350.......360.-.-----......370-.........380.......390.......400.......410.......420.......430...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKKSRFDQFGFQ
P
F
I
G
L
A
IDKLGFY
E
P
T
E
V
Q
Q
K
L
I
P
G
I
LKG--E-
S
I
IGQSQTGTGK
T
H
T
F
I
L
PIINNV--NP---
E
K
-----
D
---
A
V
--------
Q
A
V
ITAP
S
R
E
L
A
T
Q
I
Y
N
E
I
R
K
V
TKYSE
K
E
I
A
V
Q
L
V
IGGT-
D
K
Q
R
A
I
D
K
L
KKQ-P
Q
I
I
VGTP
G
R
I
N
D
L
I
R
E
Q
A
L
F
V
H
T
A
K
T
L
V
I
DEAD
M
T
L
D
-
M
G
F
LN
D
-
V
D
----
H
I
AG--KMP--A
N
L
Q
M
L
V
F
SATI
P
Q
K
L
K
P
F
L
S
K
Y
MENPRYEHI---QPKVAA
S
K
T
V
E
H
R
I
M
A
---T-RSR-
N
K
L
D
L
L
K
N
V
L----VGSQ
P
Y
L
A
I
V
FTNTKT
T
A
D
E
V
A
N
G
L
I
ERG
L
K
V
A
K
I
HGDV
N
P
R
E
R
K
R
T
M
K
Q
I
ENL
D
Y
Q
Y
V
V
ATDLAARGIDIQG
I
S
H
VVNYELPD------D
L
D
F
Y
IHRTGRTGRAGHS
G
I
A
L
T
L
FEPA
D
E
D
R
L
N
Q
L
-
E
K
-M-----G
I
E
F
KHV---DWKNK
E
F
V
T
L
E
DR
N
R
R
A
K
R
E
A
KRETA
D
P
R
E
I
G
M
R
K
K
A
KQKGKPNYK
K
K
I
N
Y
K
M
N
E
I
K
R
R
E
R
RKKR
28
PsiBlast_CBE
91.89
35%
-100
- C3 -
4KBG
4
?
B:
[3-365]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
IKD
E
P
-----
V
T
Y
E
E
E
A
V
P
---
A
-
P
V
R
-
G
R
L
E
V
L
S
D
L
L
----
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
D
V
E
A
L
-
E
R
A
V
-----
G
R
R
F
K
R
V
---
N
----------------------------------------------------------------
13
PsiBlast_PDB
91.48
35%
-98
- C3 -
4KBF
3
?
A:
[3-365]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
IKD
E
P
-----
V
T
Y
E
E
E
A
V
P
---
A
-
P
V
R
-
G
R
L
E
V
L
S
D
L
L
----
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
D
V
E
A
L
-
E
R
A
V
-----
G
R
R
F
K
R
V
---
N
----------------------------------------------------------------
29
PsiBlast_CBE
90.99
35%
-107
- C3 -
4KBF
1
?
B:
[3-365]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
IKD
E
P
-----
V
T
Y
E
E
E
A
V
P
---
A
-
P
V
R
-
G
R
L
E
V
L
S
D
L
L
----
Y
V
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
D
V
E
A
L
-
E
R
A
V
-----
G
R
R
F
K
R
V
---
N
----------------------------------------------------------------
11
PsiBlast_PDB
88.49
33%
-108
- C3 -
1HV8
5
H669_METJA
A:
[8-355]
------
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
--
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
--
N
----
E
N
-----
N
---
G
I
--------
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
--
G
N
K
N
L
K
I
A
K
I
Y
G
G
K
-
A
I
Y
P
Q
I
K
A
L
K
-
N
-
A
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
R
G
T
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
-
M
G
F
I
K
D
-
V
E
----
K
I
L
N
--
A
C
N
--
K
D
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
--
Y
S
F
I
---
K
A
K
I
N
A
N
--
I
E
Q
S
Y
V
E
---
V
-
N
E
N
-
E
R
F
E
A
L
C
R
L
L
----
K
N
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
Y
K
K
L
R
Y
I
-
E
R
----------------------------------------------------------------------------------
18
PsiBlast_PDB
88.34
29%
-100
- C3 -
4CT4
3
DDX6_HUMAN
B:
[7-367]
------
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
---
K
K
-----
D
---
N
I
--------
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
-
K
V
M
A
T
T
G
G
T
-
N
L
R
D
D
I
M
R
L
D
D
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
-
Q
D
F
V
Q
I
-
M
E
----
D
I
I
L
--
T
L
P
--
K
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
---
M
E
E
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
---
T
-
E
-
R
-
Q
K
V
H
C
L
N
T
L
F
----
S
R
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
S
I
E
E
Q
-
L
-----
G
T
E
I
K
----------------------------------------------------------------------
4
PsiBlast_PDB
88.21
32%
-96
- C3 -
2J0S
3
IF4A3_HUMAN
A:
[39-393]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
6
PsiBlast_PDB
87.91
32%
-94
- C3 -
3EX7
4
IF4A3_HUMAN
C:
[40-394]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
5
PsiBlast_PDB
87.74
32%
-95
- C3 -
2HYI
3
IF4A3_HUMAN
C:
[40-394]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
15
PsiBlast_PDB
87.70
30%
-104
- C3 -
1S2M
-
DHH1_YEAST
A:
[46-409]
----
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
---
K
L
-----
N
---
K
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
G
--
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
N
E
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
-
R
D
F
K
T
I
-
I
E
----
Q
I
L
S
--
F
L
P
--
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
-
Y
E
I
N
---
L
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
---
V
-
E
E
R
-
Q
K
L
H
C
L
N
T
L
F
----
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
-
E
Q
E
L
-----
G
T
E
I
A
A
I
--------------------------------------------------------------------
110
HHSearch
87.50
30%
-102
- C3 -
1S2M
-
DHH1_YEAST
A:
[46-411]
----
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
---
K
L
-----
N
---
K
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
--
G
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
N
E
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
-
R
D
F
K
T
I
-
I
E
----
Q
I
L
S
--
F
L
P
--
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
---
M
E
E
-
L
T
L
K
G
I
T
Q
Y
Y
A
F
---
V
-
E
E
R
-
Q
K
L
H
C
L
N
T
L
F
----
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
-
E
Q
-
E
L
----
G
T
E
I
A
A
I
---
P
A
---------------------------------------------------------------
32
PsiBlast_CBE
87.45
32%
-101
- C3 -
3PEW
10
DBP5_YEAST
A:
[7-386]
------
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
---
E
D
-----
A
---
S
P
--------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
--
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
------
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
-
Q
Q
G
L
G
D
Q
C
I
----
R
V
K
R
--
F
L
P
--
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
---
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
D
---
C
-
K
N
E
A
D
K
F
D
V
L
T
E
L
Y
GVMT
I
G
S
----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
--
D
K
N
S
F
N
I
L
-
S
A
-
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
TD
D
W
D
E
V
E
-----------------------------------------------------------
2
PsiBlast_PDB
87.07
32%
-91
- C3 -
2XB2
4
IF4A3_HUMAN
A:
[40-394]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
24
PsiBlast_CBE
87.05
32%
-93
- C3 -
2HYI
3
IF4A3_HUMAN
I:
[40-394]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
33
PsiBlast_CBE
87.04
32%
-103
- C3 -
3PEY
11
DBP5_YEAST
A:
[7-386]
------
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
---
E
D
-----
A
---
S
P
--------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
--
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
------
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
-
Q
Q
G
L
G
D
Q
C
I
----
R
V
K
R
--
F
L
P
--
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
---
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
D
---
C
-
K
N
E
A
D
K
F
D
V
L
T
E
L
Y
G
L
MT
I
G
S
----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
--
D
K
N
S
F
N
I
L
-
S
A
-
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
TD
D
W
D
E
V
E
-----------------------------------------------------------
23
PsiBlast_CBE
87.04
32%
-96
- C3 -
3EX7
4
IF4A3_HUMAN
H:
[40-394]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
17
PsiBlast_PDB
86.99
30%
-103
- C3 -
4BRW
2
DHH1_YEAST
A:
[3-364]
------
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
---
K
L
-----
N
---
K
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
G
--
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
N
E
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
-
R
D
F
K
T
I
-
I
E
----
Q
I
L
S
--
F
L
P
--
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
-
Y
E
I
N
---
L
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
---
V
-
E
E
R
-
Q
K
L
H
C
L
N
T
L
F
----
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
-
E
Q
E
L
-----
G
T
E
I
A
A
I
--------------------------------------------------------------------
22
PsiBlast_CBE
86.60
32%
-92
- C3 -
2J0Q
3
IF4A3_HUMAN
B:
[39-393]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
30
PsiBlast_CBE
86.40
32%
-104
- C3 -
3RRN
2
DBP5_YEAST
A:
[7-386]
------
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
---
E
D
-----
A
---
S
P
--------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
--
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
A
------
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
-
Q
Q
G
L
G
D
Q
C
I
----
R
V
K
R
--
F
L
P
--
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
---
Q
------
D
A
I
K
Q
L
Y
M
D
---
C
-
K
N
E
A
D
K
F
D
V
L
T
E
L
Y
GVMT
I
G
S
----
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
--
D
K
N
S
F
N
I
L
-
S
A
-
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
TD
D
W
D
E
V
E
-----------------------------------------------------------
3
PsiBlast_PDB
86.32
32%
-91
- C3 -
2J0Q
3
IF4A3_HUMAN
A:
[39-393]
------
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
---
Q
V
-----
R
---
E
T
--------
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
V
Q
C
H
A
C
I
G
G
T
-
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
-
K
G
F
K
E
Q
-
I
Y
----
D
V
Y
R
--
Y
L
P
--
P
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
---
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
A
---
V
E
R
E
E
-
W
K
F
D
T
L
C
D
L
Y
----
D
T
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------
16
PsiBlast_PDB
86.10
30%
-97
- C3 -
4BRU
-
DHH1_YEAST
A:
[3-364]
------
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
---
K
L
-----
N
---
K
I
--------
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
G
--
I
S
C
M
V
T
T
G
G
T
-
N
L
R
D
D
I
L
R
L
N
E
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
-
R
D
F
K
T
I
-
I
E
----
Q
I
L
S
--
F
L
P
--
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
-
Y
E
I
N
---
L
M
E
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
---
V
-
E
E
R
-
Q
K
L
H
C
L
N
T
L
F
----
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
-
E
Q
E
L
-----
G
T
E
I
A
A
I
--------------------------------------------------------------------
112
HHSearch
85.09
33%
-90
- C3 -
2DB3
3
VASA1_DROME
A:
[54-408]
--
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
---
D
P
H
E
L
E
L
G
---
R
P
--------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
--
S
Y
L
K
I
G
I
V
Y
G
G
T
-
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
G
F
S
E
D
-
M
R
----
R
I
M
T
--
H
V
T
MR
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
---
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
---
V
-
N
K
Y
-
A
K
R
S
K
L
I
E
I
L
----
S
-
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
--------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.34
34%
-88
- C3 -
2DB3
3
VASA1_DROME
A:
[71-410]
-------------------
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
H
E
L
E
L
-----
G
---
R
P
--------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
--
F
E
S
Y
L
K
I
G
I
V
Y
G
G
T
-
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
G
F
S
E
D
-
M
R
----
R
I
M
T
HV
T
M
R
--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
---
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
---
V
-
N
K
Y
-
A
K
R
S
K
L
I
E
I
L
-----
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
-
E
K
D
R
-----------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.31
34%
-89
- C3 -
2DB3
3
VASA1_DROME
C:
[71-410]
-------------------
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
LE
D
P
HEL
E
L
-----
G
---
R
P
--------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
--
F
E
S
Y
L
K
I
G
I
V
Y
G
G
T
-
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
G
F
S
E
D
-
M
R
----
R
I
M
T
HV
T
M
R
--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
---
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
---
V
-
N
K
Y
-
A
K
R
S
K
L
I
E
I
L
-----
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
-
E
K
D
R
-----------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.60
34%
-89
- C3 -
2DB3
3
VASA1_DROME
D:
[71-410]
-------------------
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
LE
D
P
HEL
E
L
-----
G
---
R
P
--------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
--
F
E
S
Y
L
K
I
G
I
V
Y
G
G
T
-
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
G
F
S
E
D
-
M
R
----
R
I
M
T
HV
T
M
R
--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
---
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
---
V
-
N
K
Y
-
A
K
R
S
K
L
I
E
I
L
-----
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
-
E
K
D
R
-----------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.43
34%
-88
- C3 -
2DB3
3
VASA1_DROME
B:
[71-410]
-------------------
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
LE
D
P
HEL
E
L
-----
G
---
R
P
--------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
--
F
E
S
Y
L
K
I
G
I
V
Y
G
G
T
-
S
F
R
H
Q
N
E
C
I
T
R
G
-
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-
M
G
F
S
E
D
-
M
R
----
R
I
M
T
HV
T
M
R
--
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
---
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
---
V
-
N
K
Y
-
A
K
R
S
K
L
I
E
I
L
-----
S
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
-
E
K
D
R
-----------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.86
31%
-96
- C3 -
1XTI
4
DX39B_HUMAN
A:
[9-353]
-----
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--
E
P
---
V
T
-----
G
---
Q
V
--------
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
-
P
N
V
K
V
A
V
F
F
G
G
L
-
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
K
S
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
D
M
R
R
D
-
V
Q
----
E
I
F
R
--
M
T
P
--
H
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
-
E
T
K
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
K
DN
E
-
K
N
R
-
K
L
F
D
L
L
-
D
V
L
----
E
F
N
Q
---
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.80
34%
-75
- C3 -
4D26
4
?
A:
[67-410]
---------------------
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
-
Q
D
---
P
K
-----
D
---
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
--
G
G
T
-
A
V
R
H
Q
G
D
N
I
A
R
G
-
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
-
M
G
F
M
P
S
-
I
E
K
M
M
L
H
P
T
M
--
V
E
T
--
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
---
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
---
V
-
T
K
Y
-
E
K
R
N
S
L
K
Q
L
I
----
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
D
------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.21
34%
-77
- C3 -
4D25
4
?
A:
[67-410]
---------------------
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
-
Q
D
---
P
K
-----
D
---
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
--
G
G
T
-
A
V
R
H
Q
G
D
N
I
A
R
G
-
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
-
M
G
F
M
P
S
-
I
E
K
M
M
L
H
P
T
M
--
V
E
T
--
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
---
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
E
---
V
-
T
K
Y
-
E
K
R
N
S
L
K
Q
L
I
----
E
E
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
D
------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.97
35%
-112
- C3 -
3NBF
2
?
A:
[3-200]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
66.94
35%
-116
- C3 -
3NBF
4
?
C:
[3-200]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RG
R
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
65.79
35%
-109
- C3 -
3NBF
2
?
B:
[3-200]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.68
35%
-119
- C3 -
3NBF
2
?
D:
[3-200]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.54
35%
-113
- C3 -
2GXS
4
?
B:
[3-200]
------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
---
S
Q
-----
E
RGR
K
P
--------
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
----
L
K
V
V
A
V
Y
G
G
T
-
G
Y
G
K
Q
K
E
A
L
L
R
G
-
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
-
M
G
F
E
E
E
-
V
E
----
A
L
L
S
--
A
T
P
--
P
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.95
31%
-108
- C3 -
1VEC
1
DDX6_HUMAN
B:
[1-204]
--
K
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
---
K
K
-----
D
---
N
I
--------
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
-
K
V
M
A
T
T
G
G
T
-
N
L
R
D
D
I
M
R
L
D
D
T
-
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
-
Q
D
F
V
Q
I
-
M
E
----
D
I
I
L
--
T
L
P
--
K
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
-
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------