@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1504: (2016-03-25 )
MKQLSSAEVRQLFLDFFKEKGHTIEPSAPLVPNNDPTILWINSGVATMKKYFDGSVIPDNPRMANAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEGAIVFAWEFLTSPKWIGFDPDKLYVTVYPEDEEAKTLWREKIGLSDDHIVEIEDNFWDIGIGPSGPDSEIFYDRGPAFGDDASDPELYPGGENERYLEIWNLVFSQFNHNPDGTYTPLPKQNIDTGMGLERMVSIIQDAPTNFETDLFMPIIREVEQIAGVKYGHSQENDVAFKVIADHIRTVAFAIGDGALPSNEGRGYILRRLLRRAVRYAKVLTINEPFMYKLVPVVGKIMNSFYPEVENQTDFIQKVIRTEEERFHETLNEGLAILETILKTAKETNEQVIKGADIFKLYDTFGFPVELTEEYAEDHGLKVDHAGFEAEMKEQRARARAARADVKSMQVQGELLANLTEKSAFVGYNSTEHVSEILYLIQNDTLVDEVAAGNEAQVIFKETPFYAESGGQVADKGTIESETGLAYVEDVQKAPNKQNLHRISVKEGVLKTGDTVKLAVDKVKRRETIKNHTATHLLHRALKDTLGEHVNQAGSLVSPDRLRFDFSHFGQITEEELTKMEEIVNEKIWEQINVVIEEMPIAEAKELGAMALFGEKYGDIVRVVQVGKYSIELCGGVHVRNTADIGLFKIVSETGIGAGTRRIEAVTGKEAYRFVTEQENTLKQAASLLKTTTKETPQKVELLQADLREVKRENESLLSKLASAASADIFESPEEIGGVKVIAKQVNAKDMNQLRQFVDNWKDKKIGGILVLGAVQGDKVNLISAVSEEAIKAGYHAGKLLKEVATRCGGNGGGRPDMAQAGGKNPAELGTALDYVSTWVKEQQA
Atome Classification :
(24 SA)
.........10........20........30........40........50...-.....--60........70.----.......80........90.......-----.100.......110.......120.......130.......140.......150..---------.---------....160-.-......170.......180.......190.......200.......210...-------....220.......230.......240.---------------------......250.......260.----------.....-----------------------------------------------.270.....---------------..280.......290.......300.......310.......320.......330.......340.......350.......360.......370-.......380.......390.......400.......410.......420.........430.......440...-....450.....-..460....---...470.......480.......490........500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.-....--..650........660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKQ
L
S
S
A
E
V
R
Q
L
F
L
D
F
F
K
EKGHTIEPSAPLVPNND
P
T
I
L
W
INS
G
V
A
T
M
K
K
Y
FDG-SVIPD--NPRMA
N
A
Q
KSIRT----N
D
I
E
N
V
G
K
T
A
R
H
H
T
F
F
E
M
L
GNFS
I
G
D
-----
Y
F
KE
G
A
I
V
F
A
W
EFLTSPKWIGFDP
D
K
L
Y
V
T
V
YPE
D
E
E
A
K
T
L
W
R
E
KIGLSDD
H
I
V
E
I
---------E---------D
N
F
W
DIG-I-GPSGPDSE
I
F
YDRGPAFGDDASDPELYPGGEN
E
R
Y
L
E
I
W
N
L
V
F
S
QFNHNPDG-------TYTPLPKQNIDTGM
G
L
E
R
M
V
S
I
I
QDAPT---------------------NFE
T
D
L
F
M
P
I
I
R
E
V
E
Q
I
AGV----------KYGHS-----------------------------------------------QEND
V
A
F
K
V
---------------
I
A
D
H
I
R
T
V
A
F
AIGDGALPSNEG
R
G
Y
I
L
R
R
L
L
R
R
A
V
R
Y
A
K
V
L
TINE
P
F
M
Y
K
L
V
P
V
V
G
K
I
M
N
S
FYPEVE
N
Q
T
D
F
I
Q
K
V
I
R
T
E
E
E
R
F
H
E
T
L
N
E
G
L
A
I
L
-
E
T
I
L
K
T
A
K
ET
N
E
Q
V
IKGA
D
I
F
K
L
Y
D
TFGF
P
V
E
L
T
E
E
Y
A
E
DHGLKVDHA--G
F
E
A
E
M
K
E
Q
R
A
R
A
R
A
A
RA
D
V
K
S
M
Q
V
-
Q
G
E
L
L
A
N
L
T
EK
S
-
A
FVGYN
S
T
E
---
H
V
S
E
I
L
Y
L
IQND
T
L
V
D
E
VAAGN
E
A
Q
-
V
I
F
KETPFYAESGGQVADKGTIESETG
L
A
Y
V
E
D
V
Q
KAPNKQN
L
H
R
I
SVKEGVLKTG
D
T
V
K
L
A
V
D
K
V
K
R
R
E
T
I
K
N
H
T
A
T
H
L
L
H
R
A
L
K
D
T
L
G
E
H
V
N
QAGSLVSPD
R
L
R
F
D
F
S
H
FGQI
T
E
E
E
L
T
K
M
E
E
I
V
N
E
K
I
W
E
Q
I
N
V
V
I
E
EMP
I
A
E
A
K
E
L
G
A
-
M
A
L
F
--
G
E
KY-G
D
I
V
R
V
V
Q
VG
K
Y
S
I
E
L
CG
G
V
H
VRNTAD
I
G
L
F
K
I
V
S
ETGIGAG
T
R
R
I
E
A
VTG
K
E
A
Y
R
F
V
TEQ
E
N
T
L
K
Q
A
A
S
L
L
K
T
T
TKET
P
Q
K
V
E
L
L
Q
A
D
L
R
E
V
K
R
E
N
E
S
L
L
S
K
L
A
S
A
ASADIFE
S
P
E
EIG
G
V
K
V
I
A
K
QV
N
A
K
D
M
N
Q
L
R
Q
F
V
D
NWKDKKI
G
G
I
L
V
L
G
AVQGDK
V
N
L
I
S
A
V
S
E
E
A
I
K
A
G
Y
H
A
G
K
L
L
K
E
V
A
T
RCGGNGGGR
P
D
M
A
QAGGK
N
P
A
E
L
G
T
A
L
D
Y
V
S
T
W
V
K
EQQA
28
HHSearch
89.17
29%
-64
- C3 -
3WQY
1
SYA_ARCFU
A:
[57-905]
K
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
--
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
--------------------------
V
Y
----------
K
---------
E
E
P
W
A
G
G
---
G
N
A
G
P
C
L
E
A
I
V
G
----------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
---------------------
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
----------
S
F
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
---------------
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
-
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
-
Q
E
K
K
--
I
------
T
L
Q
N
-
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
T
LL
E
F
E
A
E
V
I
G
V
E
-------------
G
D
F
-
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
-
A
-
V
G
C
L
M
A
K
G
E
G
K
V
F
V
-
V
T
F
S
G
---
Q
K
Y
-
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
-
15
PsiBlast_PDB
87.39
27%
-60
- C3 -
3WQY
1
SYA_ARCFU
A:
[64-906]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA
N
P
-
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
Y
K
---------
E
---------
E
P
W
--
A
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
-----------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSF
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
-----------------------------------------------
V
A
D
T
V
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
-
E
R
L
V
E
R
K
K
K
L
E
K
D
-----
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
-
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
--
K
K
I
T
L
-
Q
N
E
Y
P
A
--
T
E
K
L
-
Y
Y
D
D
P
T
L
L
E
---
F
E
A
E
V
I
--------------
G
V
E
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
-
F
R
L
Y
QG
G
V
P
P
-
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
-----
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
G
16
PsiBlast_PDB
86.35
27%
-61
- C3 -
3WQZ
2
SYA_ARCFU
A:
[64-906]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA
N
P
-
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
-----------------------------
E
L
G
V
K
K
E
D
I
V
Y
K
---------
E
---------
E
P
W
--
A
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
-----------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSF
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RGER
L
N
Q
L
R
K
S
-----------------------------------------------
V
A
D
T
V
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
-
E
R
L
V
E
R
K
K
K
L
E
K
D
-----
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K-
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
--
K
K
I
T
L
-
Q
N
E
Y
P
A
--
T
E
K
L
-
Y
Y
D
D
P
T
L
L
E
---
F
E
A
E
V
I
--------------
G
V
E
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
-
F
R
L
Y
QG
G
V
P
P
-
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
-----
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
H
E
G
32
HHSearch
79.66
48%
-80
- C3 -
3HY0
4
SYA_ECOLI
A:
[1-439]
--
S
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
---------
G
DNKGAPYAS
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
---
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
----------
T
D
---------------------------------------------------
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
-
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
79.24
49%
-78
- C3 -
1YFS
1
SYA_AQUAE
A:
[2-458]
--
S
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
--
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
---------
G
EE-------
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
------------
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------P
V
Y
S
H
L
K
E
-
L
G
K
T
S
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.15
46%
-80
- C3 -
3HXY
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.05
46%
-79
- C3 -
3HXZ
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.03
46%
-77
- C3 -
3HXX
3
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.00
46%
-79
- C3 -
3HXZ
4
SYA_ECOLI
C:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.00
46%
-78
- C3 -
3HXW
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.90
46%
-78
- C3 -
3HY0
4
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.87
46%
-79
- C3 -
3HY0
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.82
46%
-78
- C3 -
3HXZ
6
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.78
47%
-76
- C3 -
1YFS
1
SYA_AQUAE
B:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
GE-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.69
47%
-76
- C3 -
1YFS
1
SYA_AQUAE
A:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.67
46%
-78
- C3 -
3HXZ
4
SYA_ECOLI
D:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.58
47%
-74
- C3 -
1YFR
3
SYA_AQUAE
A:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.53
46%
-75
- C3 -
3HY1
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.45
47%
-77
- C3 -
3HTZ
-
SYA_AQUAE
A:
[2-457]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
---------
K
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.34
46%
-79
- C3 -
3HXU
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.21
47%
-78
- C3 -
1YGB
1
SYA_AQUAE
A:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.20
46%
-78
- C3 -
3HXV
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
---------
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
---
W
G
G
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
--------------
T
-----------------------------------------------
D
L
S
N
K
S
L
R
V
---------------
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
D
T
----
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
A
R
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.99
47%
-75
- C3 -
1YFT
1
SYA_AQUAE
A:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
G
E-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.92
47%
-75
- C3 -
1YFR
4
SYA_AQUAE
B:
[3-458]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
V
--
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
R
L
GE-------
E
---------
D
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
----------
K
Y
G
E
K
-----------------------------------------------
F
E
T
D
V
A
L
R
V
---------------
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
-
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
--------
P
-
V
Y
S
H
L
K
E
L
G
K
T
S
-
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------