@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1570: (2016-03-26 )
MKKTKIVCTIGPASESVDTLVQLIEAGMNVARLNFSHGDFEEHGARIVNIREASKKTGKQVAILLDTKGPEIRTNDMVGGKLEFQTGDVVRVSMTPVEGTKEKFSVTYGELYDDVEIGSSILLDDGLIGLEVIEKDEANRELVTKVLNPGVLKNKKGVNVPNVSINLPGITEKDAADIRFGLEQGIDFIAASFVRRATDVLEITKILEEHNATHVQIIPKIENQEGVDNIDEILQVSQGLMVARGDLGVEIPAEEVPIVQKELIRKCNKLGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGDYPVEAVKMMAKIAVRTEEVLVAQDKFALKLHENTDMTEAIGQAVGHTAKNLNVQTIVAATQSGHTARMISKYRPKSHIVAVTFNEHVYRGLALSWGVYPRLATPVSNTDEMFDLAVKESLASGVAKQGDLIIITAGVPVTESGTTNVMKIQLIGEKVVKGQGIGSKSVIGKAIVAKSNAEALEKAEEGGILIVKTTDKEILPAFEKSAAVVVEEGGLTSHAAVVGINLGIPVIVGAKDATSLVKDGEIITVDSRQGVVYNGKTATH
Atome Classification :
(21 SA)
.........10........20........30........40........50.......------.60........70........---80-........90...--.....100.-......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340...---..-----.-.-350-.......360.......370.......380.......390.......400.......410.......420-...-----....430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
T
K
I
V
C
T
IGPAS
E
S
V
D
T
L
V
Q
L
I
E
AGM
N
V
A
R
L
NFSHG
D
F
E
EHG
A
R
I
V
N
I
R
E
ASKKTG------
K
Q
V
A
I
L
L
DTKGP
E
I
RTNDMVG---
G
K
-
L
E
F
QTG
D
V
V
R
V
S
M--TPVEGT
K
E
K
-
F
S
V
T
Y
G
E
L
Y
D
D
V
EIG
S
S
I
LLDDGL
I
G
L
E
V
IEKDEA
N
R
E
L
V
T
K
VLNPGVLKNKKGVNVP
N
V
S
I
NLPGITEKD
A
A
D
I
R
F
G
L
E
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
T
D
V
L
E
I
T
K
I
L
E
EHNA
T
H
V
Q
I
I
P
KIENQEGVD
N
I
D
E
I
L
Q
V
SQ
G
L
M
V
ARGDLGVEI
P
A
E
EVP
I
V
Q
K
E
L
I
R
K
C
N
KLGK
P
V
I
T
A
T
Q
M
L
D
S
M
QRNPRPTRA
E
A
S
D
V
A
N
A
I
FDGT
D
A
I
M
LSGETAAGDY
P
V
E
A
V
K
M
M
A
K
I
A
VR
T
E
E
V
L
V
AQ
D
K
F
---
A
L
-----
K
-L-HEN-T
D
M
T
E
A
I
G
Q
A
VGHTAKN
L
N
V
Q
T
I
V
A
ATQSG
H
T
A
R
M
I
S
KYRPKS
H
I
V
A
V
TFNE
H
V
Y
R
G
LALSWGVYPRLAT-PVS-----
N
T
D
E
M
F
D
L
A
V
K
E
S
L
A
S
G
VAKQG
D
L
I
I
I
TAGVPVTESGTT
N
V
M
K
I
Q
L
IGEKVVKGQGIGS
K
S
V
IG
K
A
I
VAKS
N
A
E
A
L
E
K
AEEG
G
I
L
I
V
KTT
D
K
E
I
L
P
A
FEK
S
A
A
V
V
V
EEGGLTS
H
A
A
V
V
G
I
NLGI
P
V
I
VGAK
D
A
T
S
LVKDG
E
I
I
T
V
DSRQ
G
V
V
YNGKTATH
119
HHSearch
97.33
66%
-86
- C6 -
2E28
1
KPYK_GEOSE
A:
[2-586]
K
R
K
T
K
I
V
S
T
I
G
P
A
S
E
S
V
D
K
L
V
Q
L
M
E
A
G
M
N
V
A
R
L
N
F
S
H
G
D
H
E
E
H
G
R
R
I
A
N
I
R
E
A
A
K
R
T
G
------
R
T
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
E
N
---
G
A
-
I
E
L
K
E
G
S
K
L
V
I
S
M
--
S
E
V
L
G
T
P
E
K
-
I
S
V
T
Y
P
S
L
I
D
D
V
S
V
G
A
K
I
L
L
D
D
G
L
I
S
L
E
V
N
A
V
D
K
Q
A
G
E
I
V
T
T
V
L
N
G
G
V
L
K
N
K
K
G
V
N
V
P
G
V
K
V
N
L
P
G
I
T
E
K
D
R
A
D
I
L
F
G
I
R
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
S
D
V
L
E
I
R
E
L
L
E
A
H
D
A
L
H
I
Q
I
I
A
K
I
E
N
E
E
G
V
A
N
I
D
E
I
L
E
A
A
D
G
L
M
V
A
R
G
D
L
G
V
E
I
P
A
E
E
V
P
L
I
Q
K
L
L
I
K
K
S
N
M
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
P
T
R
A
E
A
S
D
V
A
N
A
I
F
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
Q
Y
P
V
E
A
V
K
T
M
H
Q
I
A
L
R
T
E
Q
A
L
E
H
R
D
I
L
---
S
Q
-----
R
T
K
-
E
S
Q
-
T
T
I
T
D
A
I
G
Q
S
V
A
H
T
A
L
N
L
D
V
A
A
I
V
T
P
T
V
S
G
K
T
P
Q
M
V
A
K
Y
R
P
K
A
P
I
I
A
V
T
S
N
E
A
V
S
R
R
L
A
L
V
W
G
V
Y
T
K
E
A
P
-
H
V
N
-----
T
T
D
E
M
L
D
V
A
V
D
A
A
V
R
S
G
L
V
K
H
G
D
L
V
V
I
T
A
G
V
P
V
G
E
T
G
S
T
N
L
M
K
V
H
V
I
S
D
L
L
A
K
G
Q
G
I
G
R
K
S
A
F
G
K
A
V
V
A
K
T
A
E
E
A
R
Q
K
M
V
D
G
G
I
L
V
T
V
S
T
D
A
D
M
M
P
A
I
E
K
A
A
A
I
I
T
E
E
G
G
L
T
S
H
A
A
V
V
G
L
S
L
G
I
P
V
I
V
G
V
E
N
A
T
T
L
F
K
D
G
Q
E
I
T
V
D
G
G
F
G
A
V
Y
R
G
H
A
S
V
-
1
PsiBlast_PDB
97.19
66%
-86
- C6 -
2E28
1
KPYK_GEOSE
A:
[3-585]
-
R
K
T
K
I
V
S
T
I
G
P
A
S
E
S
V
D
K
L
V
Q
L
M
E
A
G
M
N
V
A
R
L
N
F
S
H
G
D
H
E
E
H
G
R
R
I
A
N
I
R
E
A
A
K
R
T
G
------
R
T
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
E
N
---
G
A
-
I
E
L
K
E
G
S
K
L
V
I
S
M
--
S
E
V
L
G
T
P
E
K
-
I
S
V
T
Y
P
S
L
I
D
D
V
S
V
G
A
K
I
L
L
D
D
G
L
I
S
L
E
V
N
A
V
D
K
Q
A
G
E
I
V
T
T
V
L
N
G
G
V
L
K
N
K
K
G
V
N
V
P
G
V
K
V
N
L
P
G
I
T
E
K
D
R
A
D
I
L
F
G
I
R
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
S
D
V
L
E
I
R
E
L
L
E
A
H
D
A
L
H
I
Q
I
I
A
K
I
E
N
E
E
G
V
A
N
I
D
E
I
L
E
A
A
D
G
L
M
V
A
R
G
D
L
G
V
E
I
P
A
E
E
V
P
L
I
Q
K
L
L
I
K
K
S
N
M
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
P
T
R
A
E
A
S
D
V
A
N
A
I
F
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
Q
Y
P
V
E
A
V
K
T
M
H
Q
I
A
L
R
T
E
Q
A
L
E
H
R
D
I
L
---
S
Q
-----
R
-
T
-
K
E
S
Q
T
T
I
T
D
A
I
G
Q
S
V
A
H
T
A
L
N
L
D
V
A
A
I
V
T
P
T
V
S
G
K
T
P
Q
M
V
A
K
Y
R
P
K
A
P
I
I
A
V
T
S
N
E
A
V
S
R
R
L
A
L
V
W
G
V
Y
T
K
E
A
P
-
H
V
N
-----
T
T
D
E
M
L
D
V
A
V
D
A
A
V
R
S
G
L
V
K
H
G
D
L
V
V
I
T
A
G
V
P
V
G
E
T
G
S
T
N
L
M
K
V
H
V
I
S
D
L
L
A
K
G
Q
G
I
G
R
K
S
A
F
G
K
A
V
V
A
K
T
A
E
E
A
R
Q
K
M
V
D
G
G
I
L
V
T
V
S
T
D
A
D
M
M
P
A
I
E
K
A
A
A
I
I
T
E
E
G
G
L
T
S
H
A
A
V
V
G
L
S
L
G
I
P
V
I
V
G
V
E
N
A
T
T
L
F
K
D
G
Q
E
I
T
V
D
G
G
F
G
A
V
Y
R
G
H
A
S
--
27
PsiBlast_CBE
95.16
58%
-93
- C6 -
3T05
1
KPYK_STAAR
D:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
25
PsiBlast_CBE
95.15
58%
-93
- C6 -
3T07
2
KPYK_STAAR
C:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
23
PsiBlast_CBE
95.11
58%
-92
- C6 -
3T0T
2
KPYK_STAAR
B:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
24
PsiBlast_CBE
94.89
58%
-93
- C6 -
3T07
2
KPYK_STAAR
D:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
28
PsiBlast_CBE
94.88
58%
-93
- C6 -
3T05
1
KPYK_STAAR
C:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
21
PsiBlast_CBE
94.76
58%
-93
- C6 -
3T0T
2
KPYK_STAAR
D:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
22
PsiBlast_CBE
94.75
58%
-92
- C6 -
3T0T
2
KPYK_STAAR
C:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
4
PsiBlast_PDB
94.63
58%
-93
- C6 -
3T0T
2
KPYK_STAAR
A:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
L
S
D
R
T
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
29
PsiBlast_CBE
94.29
58%
-93
- C6 -
3T05
1
KPYK_STAAR
B:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
2
PsiBlast_PDB
94.27
58%
-93
- C6 -
3T05
1
KPYK_STAAR
A:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
L
S
D
R
T
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
26
PsiBlast_CBE
94.26
58%
-93
- C6 -
3T07
2
KPYK_STAAR
B:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
LSDRT
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
3
PsiBlast_PDB
93.98
58%
-92
- C6 -
3T07
2
KPYK_STAAR
A:
[22-601]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
---
A
A
Q
D
Y
K
---
K
L
L
S
D
R
T
K
-
L
-
V
E
--
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
-----
118
HHSearch
93.38
57%
-89
- C6 -
3T05
1
KPYK_STAAR
A:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
L
D
------
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
---
G
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
--
N
E
V
E
G
T
P
E
K
-
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
-
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
---
S
D
-----
R
-
T
K
L
V
E
-
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
V
V
K
K
-
G
R
K
-----
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
34
PsiBlast_CBE
85.24
51%
-84
- C6 -
4YNG
1
KPYK1_ECOLI
C:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
G
------
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
---
G
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D-
K
S
V
I
G
N
S
E
M
-
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
-
E
G
N
K
-
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
L
E
F
---
N
-----------
R
K
-
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
Q
L
V
K
-
E
I
T
-----
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
L
V
P
-
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
84.67
51%
-86
- C6 -
4YNG
2
KPYK1_ECOLI
D:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
G
------
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
---
G
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D-
K
S
V
I
G
N
S
E
M
-
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
-
E
G
N
K
-
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
L
------------------
K
-
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
Q
L
V
K
-
E
I
T
-----
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
L
V
P
-
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.50
51%
-85
- C6 -
4YNG
1
KPYK1_ECOLI
G:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
G
------
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
---
G
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D-
K
S
V
I
G
N
S
E
M
-
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
-
E
G
N
K
-
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
L
E
F
-------------------
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
Q
L
V
K
-
E
I
T
-----
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
L
V
P
-
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
84.45
51%
-84
- C6 -
4YNG
2
KPYK1_ECOLI
B:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
G
------
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
---
G
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D-
K
S
V
I
G
N
S
E
M
-
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
-
E
G
N
K
-
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
L
E
-----------------
K
-
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
Q
L
V
K
-
E
I
T
-----
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
L
V
P
-
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
84.12
51%
-86
- C6 -
4YNG
2
KPYK1_ECOLI
F:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
G
------
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
---
G
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D-
K
S
V
I
G
N
S
E
M
-
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
-
E
G
N
K
-
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
L
E
F
----------------
K
-
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
Q
L
V
K
-
E
I
T
-----
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
L
V
P
-
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
78.36
44%
-78
- C6 -
3N25
43
KPYM_RABIT
H:
[43-527]
-
R
N
T
G
I
I
C
T
I
G
P
A
S
R
S
V
E
T
L
K
E
M
I
K
S
G
M
N
V
A
R
M
N
F
S
H
G
T
H
E
Y
H
A
E
T
I
K
N
V
R
T
A
T
E
S
F
A
SDPILY
R
P
V
A
V
A
L
D
T
K
G
P
E
I
R
T
G
L
I
K
G
SGT
A
E
-
V
E
L
K
K
G
A
T
L
K
I
T
L
DN
A
Y
M
E
K
C
D
E
N
I
L
W
L
D
Y
K
N
I
C
K
V
V
D
V
G
S
K
V
Y
V
D
D
G
L
I
S
L
Q
V
--
K
Q
K
G
-
D
F
L
V
T
E
V
E
N
G
G
F
L
G
S
K
K
G
V
N
L
P
G
A
A
V
D
L
P
A
V
S
E
K
D
I
Q
D
L
K
F
G
V
E
Q
D
V
D
M
V
F
A
S
F
I
R
K
A
A
D
V
H
E
V
R
K
I
L
G
E
-
K
G
K
N
I
K
I
I
S
K
I
E
N
H
E
G
V
R
R
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
I
E
I
P
A
E
K
V
F
L
A
Q
K
M
I
I
G
R
C
N
R
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
I
K
K
P
R
P
T
R
A
E
G
S
D
V
A
N
A
V
L
D
G
A
D
C
I
M
L
S
G
E
T
A
K
G
D
Y
P
L
E
A
V
R
M
Q
H
L
I
A
R
E
A
E
A
A
M
F
H
R
K
L
F
EEL
A
R
-----
A
-
S
-
S
Q
S
-
T
D
L
M
E
A
M
A
M
G
S
V
E
A
S
Y
K
C
L
A
A
A
L
I
V
L
T
E
S
G
R
S
A
H
Q
V
A
R
Y
R
P
R
A
P
I
I
A
V
T
R
N
H
Q
T
A
R
Q
A
H
L
Y
R
G
I
F
P
V
V
C
K
D
P
V
Q
EAWAE
D
V
D
L
R
V
N
L
A
M
N
V
G
K
A
R
G
F
F
K
K
G
D
V
V
I
V
L
T
G
W
R
-
P
G
S
G
F
T
N
T
M
R
V
--------------------------------------------------------------------------------------------------------------------