@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1634: (2016-03-27 )
MAIKENAAQEVLEVQKVIDRLADNGQKALKAFESYNQEQVDNIVHAMALAGLDQHMPLAKLAVEETGRGLYEDKCIKNIFATEYIWNNIKNNKTVGVINEDLQTGVIEIAEPVGVVAGVTPVTNPTSTTLFKAIIAIKTRNPIIFAFHPSAQRCSSAAAKVVYDAAIAAGAPEHCIQWVEKPSLEATKQLMNHDKVALVLATGGAGMVKSAYSTGKPALGVGPGNVPAYIDKTAKIKRSVNDIILSKSFDQGMICASEQAVIVDKEVAKEVKAEMEANNCYFVKGAEFKKLESYVINPEKGTLNPDVVGKSPAWIANQAGFKVPEDTKILVAEIKGVGDKYPLSHEKLSPVLAFIEAANQAEAFDRCEEMLVYGGLGHSAVIHSTDKEVQKAFGIRMKACRIIVNAPSAQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVSATNLLNVKRIADRRNNMQWFKLPPKIFFEKYSTQYLQKMEGVERVFIVTDPGMVQFKYVDVVIEHLKKRGNDVSYQVFADVEPDPSDVTVYKGAELMKDFKPDTIIALGGGSAMDAAKGMWLFYEHPEASFFGLKQKFLDIRKRTFKYPKLGGKAKFVAIPTTSGTGSEVTPFAVITDKENNIKYPLADYELTPDVAIVDAQYVTTVPAHITADTGMDVLTHAIESYVSVMASDYTRGLSIRAIELVFENLRESVLTGDPDAREKMHNASALAGMAFANAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNALKPKKHALFPRYESFRADEDYARISRIIGFPAATTEEGVKSLVDEIIKLGKDVGIDMSLKGQNVAKKDLDAVVDTLADRAFMDQCTTANPKQPLVSELKEIYLEAYKGV
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280---------------------.........290.......300......-.310.......320.......330....-...340.......350.......360.......370..-.....380....---...390--.........400.......410.......420.......-.430.......440.......450.......460.......470.......-480--........490......--.--500.......510.......520.......530.......540.......550.......560.......570........580..----.....590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......-700........710.......720.......730.......740.......750......-.760.......770...-....780....--...790..--.......800.......810.......820.......830.......840.......850.......860....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAI
K
E
N
A
A
Q
E
V
L
E
V
Q
K
V
I
D
R
L
ADN
G
Q
K
A
L
K
A
F
E
SY
N
Q
E
Q
V
D
N
I
V
H
A
M
A
L
AG
L
D
QHM
P
L
A
K
L
A
V
E
E
TGRGL
Y
E
D
K
C
I
K
N
I
F
A
T
E
Y
I
W
N
NIKNN
K
T
V
G
V
I
N
E
D
L
QT
G
V
I
E
I
AEPV
G
V
VAGVTPVTNP
T
S
T
T
L
F
K
A
I
I
A
I
KTRN
P
I
I
F
A
FHP
S
A
Q
R
C
S
S
A
A
A
K
V
V
Y
D
A
A
IAAGA
P
E
H
C
I
Q
W
V
EKP
S
L
E
A
T
K
Q
L
MNHD
K
V
A
L
V
L
ATGGA
G
M
V
K
S
AYSTGKPALGVGPGNV
P
A
Y
I
D
K
T
A
K
I
K
R
S
V
N
D
I
I
LSKSFDQGMICASE
Q
A
V
I
V
D
K
E
V
A
K
E
V
K
A
EMEAN
N
C
-----------------------
Y
F
VKGA
E
F
K
K
L
E
S
Y
V
INPEKGTLNPDVV-GKSP
A
W
IANQAGFKVPED
T
K
I
L
V
A
E
IKG-VGDKYPL
S
H
E
K
L
S
P
V
L
A
F
I
E
AA
N
Q
A
E
A
F
D
R
C
E
E
M
L
V
YG-GLGHS
A
V
IHST
D
---
K
E
V
Q
----
K
A
F
G
I
R
M
K
A
C
R
I
I
V
NAPSAQGG
I
G
D
I
Y
NGFI-P
S
L
T
LGC-GSYGK
N
S
V
SQNVSATN
L
L
N
V
K
R
I
A
D
RRNN
M
Q
W
F
KL
P
P
K
I
F
F
E
K
Y
S
T
Q
Y
L
Q
K
-ME---GV
E
R
V
F
I
VTDP
G
M
V
Q
F
K
--
Y
--
V
D
V
V
I
E
H
L
K
KRGNDV
S
Y
Q
V
F
ADVEPDPSD
V
T
V
YK
G
A
E
L
M
K
DFKP
D
T
I
I
A
LGGGSAMDAAK
G
M
W
L
F
Y
EHP
E
A
-
S
F
F
G
L
K
Q
K
F
L
D
I
R
K
----
R
TFKYPKLGG
K
A
K
F
V
A
I
PTTSGTGSE
V
T
P
F
A
V
I
TDKENNIKYPLADYELTP
D
V
A
I
V
DA
Q
Y
V
T
TVP
A
H
I
TADT
G
M
D
V
L
T
H
A
I
E
S
Y
V
S
V
M
A
S
D
YTRGL
S
I
R
A
I
E
L
V
F
E
N
L
R
E
S
VLTG-D
P
-
D
A
R
E
K
MH
N
A
S
A
L
A
G
M
A
F
A
N
A
F
L
GI
N
H
S
L
A
H
KIGPEFHIPHGRA
N
A
I
L
MP
H
V
I
RYNAL-KPKKHALF
P
R
Y
E
SFRA
D
-
E
D
Y
A
R
I
S
R
I
IG--FPAA--
T
T
--
E
E
G
V
K
S
L
V
D
E
I
I
K
L
G
K
DVGI
D
M
SLKGQN
V
A
K
K
D
L
D
A
V
V
D
T
L
A
D
R
A
F
M
D
QCTTANPKQ
P
L
V
S
E
L
K
E
I
Y
L
E
A
YKGV
2
PsiBlast_PDB
94.09
44%
-75
- C1 -
3K9D
1
?
A:
[3-446]
--
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
----
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
-----------------------
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
-
N
G
S
M
N
P
A
I
V
-
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
-
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
----
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.83
44%
-75
- C1 -
3K9D
2
?
C:
[4-446]
---
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
----
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
-----------------------
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
-
N
G
S
M
N
P
A
I
V
-
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
-
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
----
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Fugue
93.47
43%
-74
- C1 -
3K9D
1
?
A:
[3-456]
------
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
-----------------------
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
-
G
S
M
N
P
A
I
V
-
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
-
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
----
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.88
44%
-74
- C1 -
3K9D
1
?
B:
[3-446]
--
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
----
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
-----------------------
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
-
N
G
S
M
N
P
A
I
V
-
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
E
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
-
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
----
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.81
47%
-81
- C1 -
3MY7
1
?
A:
[17-449]
-------------------------
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
-----------------------
H
V
L
S
K
T
D
A
D
K
V
R
K
V
L
L
--
I
D
G
A
L
N
A
K
I
V
-
G
Q
P
A
T
A
I
A
E
M
A
G
V
K
V
P
A
D
T
K
V
L
I
G
E
G
L
G
K
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
-
G
I
G
H
T
S
G
L
Y
-
T
N
---
Q
D
V
N
A
D
R
I
R
Y
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
81.22
39%
-61
- C1 -
3K9D
1
?
A:
[3-451]
------
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
RPNGSMN
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
--
P
A
D
A
R
V
L
I
A
E
E
-----------------------
T
K
-
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
-
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
---
K
E
I
I
----
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
P
A
L
T
L
G
C
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
79.78
45%
-64
- C1 -
3MY7
1
?
A:
[2-449]
----------
P
V
T
N
M
A
E
L
D
A
M
I
A
R
V
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
H
V
L
S
K
T
D
A
D
K
V
R
K
V
---------
L
L
I
D
G
A
L
N
A
K
I
V
G
Q
P
A
T
A
I
A
--
E
M
A
----
G
V
---
K
V
P
A
D
T
K
V
L
I
G
E
G
-------
L
G
K
-
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
-
G
I
G
H
T
S
G
L
Y
T
N
Q
DVN
A
D
R
I
----
R
Y
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
78.09
36%
-68
- C2 -
1RRM
4
FUCO_ECOLI
A:
[4-385]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
-
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
--
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
------
L
--------
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
---------------
F
T
G
-
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
V
E
GM
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
G
-
69
HHSearch
77.71
34%
-73
* C2 *
3BFJ
1
DHAT_KLEPN
A:
[6-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
-
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
K
G
L
R
K
D
G
--
A
--
V
D
K
T
L
H
Y
L
R
E
A
--
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
D
--
L
Y
Q
Y
A
G
I
E
--------------
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
-
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
---------------
A
N
P
-
E
K
F
A
D
I
A
E
L
M
G
--
E
N
I
T
GL
S
T
--
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
----
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
---
7
PsiBlast_PDB
76.52
33%
-74
- C2 -
3OWO
1
ADH2_ZYMMO
A:
[29-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
G
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
G
--
V
--
V
K
Q
V
A
D
L
L
K
A
Q
G
--
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
-----
A
-
T
N
G
G
E
V
K
D
Y
E
G
I
D
K
----
S
--
K
K
P
A
L
----
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
-
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
------
S
V
V
A
G
R
L
K
D
----------
V
G
V
A
M
G
--
L
D
I
A
--
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
---
59
HHSearch
75.93
33%
-74
- C2 -
3OX4
2
ADH2_ZYMMO
A:
[4-383]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
GS-
G
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
G
--
V
--
V
K
Q
V
A
D
L
L
K
A
Q
--
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
E
--
V
K
D
Y
E
G
I
D
--------------
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
-
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
---------------
V
V
A
-
G
R
L
K
D
V
G
V
A
M
G
--
L
D
I
A
NL
G
D
--
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
---
8
PsiBlast_PDB
75.93
33%
-76
- C2 -
3OX4
2
ADH2_ZYMMO
A:
[29-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
G
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
G
--
V
--
V
K
Q
V
A
D
L
L
K
A
Q
G
--
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
-----
A
-
T
N
G
G
E
V
K
D
Y
E
G
I
D
K
----
S
--
K
K
P
A
L
----
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
-
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
------
S
V
V
A
G
R
L
K
D
----------
V
G
V
A
M
G
--
L
D
I
A
--
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
---
41
PsiBlast_CBE
75.92
33%
-75
- C2 -
3BFJ
1
DHAT_KLEPN
D:
[29-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
L
L
---
G
G
K
K
A
L
L
V
T
D
K
G
L
R
--
K
DG
A
--
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
--
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
----
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
----------------
F
A
D
I
A
E
L
M
G
EN
I
T
G
L
--
S
T
--
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
---
3
PsiBlast_PDB
75.87
35%
-77
- C2 -
2BI4
3
FUCO_ECOLI
A:
[36-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
---
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
G
--
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
----
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--------------
D
F
T
G
--
E
K
Y
R
D
I
A
R
V
M
G
VK
V
E
G
M
--
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
---
5
PsiBlast_PDB
75.48
35%
-68
- C2 -
1RRM
4
FUCO_ECOLI
A:
[27-385]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
---
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
G
--
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
----
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--------------
D
F
T
G
--
E
K
Y
R
D
I
A
R
V
M
G
VK
V
E
G
M
--
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
G
-
9
PsiBlast_PDB
75.42
33%
-77
- C2 -
4FR2
1
?
A:
[40-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
M
L
---
G
M
K
K
P
V
I
V
T
D
K
F
L
E
N
L
K
--
N
GA
V
A
Q
T
L
A
S
L
K
K
S
G
--
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
D
------------
D
I
T
K
LAGI
E
T
L
K
N
P
L
----
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
-
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
----------------
A
D
P
E
R
F
A
E
L
A
R
I
M
G
EN
T
D
G
L
--
S
T
--
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
----
D
L
M
A
E
N
A
L
K
D
G
N
A
F
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
---
39
PsiBlast_CBE
75.37
33%
-76
- C2 -
3BFJ
1
DHAT_KLEPN
F:
[29-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
L
L
---
G
G
K
K
A
L
L
V
T
D
K
G
L
R
--
K
DG
A
--
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
--
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
----
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
----------------
F
A
D
I
A
E
L
M
G
EN
I
T
G
L
--
S
T
--
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
---
40
PsiBlast_CBE
75.25
33%
-74
- C2 -
3BFJ
1
DHAT_KLEPN
E:
[29-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
L
L
---
G
G
K
K
A
L
L
V
T
D
K
G
L
R
--
K
DG
A
--
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
--
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
----
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
----------------
F
A
D
I
A
E
L
M
G
EN
I
T
G
L
--
S
T
--
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
----
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
---
46
PsiBlast_CBE
75.07
33%
-73
- C2 -
3OX4
2
ADH2_ZYMMO
B:
[29-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
G
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
G
--
V
--
V
K
Q
V
A
D
L
L
K
A
Q
G
--
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
-----
A
-
T
N
G
G
E
V
K
D
Y
E
G
I
D
K
----
S
--
K
K
P
A
L
----
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
-
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
------
S
V
V
A
G
R
L
K
D
----------
V
G
V
A
M
G
--
L
D
I
A
--
N
L
GD
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
---
44
PsiBlast_CBE
74.81
33%
-70
- C2 -
3OX4
2
ADH2_ZYMMO
D:
[29-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
G
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
G
--
V
--
V
K
Q
V
A
D
L
L
K
A
Q
G
--
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
-----
A
-
T
N
G
G
E
V
K
D
Y
E
G
I
D
K
----
S
--
K
K
P
A
L
----
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
-
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
------
S
V
V
A
G
R
L
K
D
----------
V
G
V
A
M
G
--
L
D
I
A
--
N
L
GD
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
---
24
PsiBlast_CBE
74.10
35%
-75
- C2 -
2BI4
2
FUCO_ECOLI
B:
[36-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
---
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
G
--
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
----
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--------------
D
F
T
G
--
E
K
Y
R
D
I
A
R
V
M
G
VK
V
E
G
M
--
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
---
4
PsiBlast_PDB
74.07
35%
-75
- C2 -
2BL4
3
FUCO_ECOLI
A:
[36-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
---
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
G
--
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
----
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--------------
D
F
T
G
--
E
K
Y
R
D
I
A
R
V
M
G
VK
V
E
G
M
--
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
---
23
PsiBlast_CBE
73.77
35%
-73
- C2 -
2BL4
2
FUCO_ECOLI
B:
[36-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
R
R
---
G
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
C
G
--
V
--
V
A
K
V
T
D
K
M
D
A
A
G
--
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
----
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
-
A
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--------------
D
F
T
G
--
E
K
Y
R
D
I
A
R
V
M
G
VK
V
E
G
M
--
S
L
--
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
---
11
PsiBlast_PDB
44.06
32%
-44
- C2 -
1O2D
3
?
A:
[68-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
-----------
L
K
E
K
D
L
S
V
E
D
-----
L
Y
D
R
E
K
V
K
H
W
L
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
N
K
R
G
C
T
L
M
F
---
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
-
E
G
-
N
R
-
E
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
--------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.56
32%
-42
- C2 -
1VHD
3
?
A:
[58-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
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V
M
K
A
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R
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R
N
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D
F
V
V
G
L
G
G
G
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M
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A
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A
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A
V
L
-----------
L
K
E
K
D
L
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D
-----
L
Y
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H
W
L
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V
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L
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N
K
R
G
C
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---
P
V
Y
A
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Y
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Y
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M
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D
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P
S
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A
L
A
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A
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I
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-
E
G
-
N
R
-
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A
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K
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A
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A
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Q
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V
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