@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1685: (2016-03-27 )
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERASGAYFYDVDGNKYIDYLAAFGPIITGHAHPHITEAITKAAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGPSTLGIPDSAGVTKSTAEEVITVPFNDLDSFKEALAIWGDQVAAVLVEPIVGNFGMVAPEDGFLEAVNELAHVNGSLVIYDEVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGTHAGNPASILSGIACLEVLQEEGLYERFEKYGSMLKDGIEKAAAKHNIAVTVNQIVGALTVYFTEDPVTNYAEAGATNGELFGRFFKGMLEEGINLAPSKYEAWFITSAHSEADILETIQAVDTVFGKMVQDN
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.--.......300.......310.......320........330.......340......---.350-.......360.......370.......380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
H
S
M
S
K
K
L
H
D
E
A
L
L
H
I
VGGVNSPSRSNKGVGGGI
P
V
T
M
ERAS
G
A
Y
F
Y
DVDG
N
K
Y
I
D
Y
L
A
AFGPIITGHAH
P
H
I
T
E
A
I
T
K
A
AQNG
V
L
YGTPTKHE
I
T
F
A
K
M
L
K
E
AIP
S
L
E
K
V
R
FTNS
G
T
E
A
V
M
T
T
I
R
V
A
R
AYTGRD
K
I
I
K
F
A
G
C
YHG
H
F
D
L
V
L
V
EAGSGPSTLGIPDSAGVTKSTAE
E
V
I
T
VPF
N
D
L
D
S
F
K
E
A
L
A
I
W
G
D
Q
V
A
A
V
L
V
E
P
I
VGNFGMVAPED
G
F
L
E
A
V
N
E
L
A
HVNG
S
L
V
I
Y
D
E
V
I
T
A
F
R
F
M
YGGA
Q
N
YLGVIP
D
L
T
A
M
G
K
I
IGGGLPIGAYGG
R
I
D
I
M
E
KVAP-L--GPAYQAGTHAG
N
P
A
S
I
L
S
G
I
A
C
L
E
V
L
Q
EE-
G
L
Y
E
R
F
E
K
Y
G
S
M
L
K
D
G
I
E
K
A
A
AKH
N
I
A
---
V
T
V
N
-
Q
IV
G
A
L
T
V
Y
FTEDPVT
N
Y
A
EAGAT
N
G
E
L
F
G
R
F
F
K
G
M
L
EEGINLAPSK
Y
E
A
W
F
I
TSAHS
E
A
D
I
L
E
T
I
Q
A
V
D
T
V
F
G
K
M
VQDN
4
PsiBlast_PDB
91.30
50%
-101
- C1 -
2HOZ
3
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
12
PsiBlast_PDB
89.10
47%
-94
- C1 -
3BS8
1
GSA_BACSU
A:
[12-437]
--
Y
E
K
S
K
T
A
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
R
A
F
K
S
V
D
M
D
-
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
E
Y
G
T
S
F
G
A
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
P
D
S
P
G
V
P
E
G
I
A
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
Q
I
A
P
-
S
--
G
P
I
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
Q
L
T
P
D
-
S
-
Y
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
P
---
H
T
F
N
-
R
A
G
S
M
I
G
F
F
F
T
N
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
I
S
R
--
11
PsiBlast_PDB
88.68
50%
-96
- C1 -
3GSB
3
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
7
PsiBlast_PDB
88.38
50%
-96
- C1 -
3FQ7
2
GSA_SYNP6
A:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
25
PsiBlast_CBE
88.31
50%
-101
- C1 -
2HOZ
2
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
108
HHSearch
87.66
47%
-92
- C1 -
2E7U
4
GSA_THET8
A:
[1-424]
M
E
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
-
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
-------
10
PsiBlast_PDB
87.58
50%
-94
- C1 -
4GSA
2
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
128
Fugue
87.45
48%
-90
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
-
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
6
PsiBlast_PDB
87.07
50%
-98
- C1 -
2HP2
3
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
9
PsiBlast_PDB
86.93
50%
-93
- C1 -
2GSA
2
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
31
PsiBlast_CBE
86.92
50%
-97
- C1 -
2GSA
2
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
29
PsiBlast_CBE
86.89
50%
-96
- C1 -
4GSA
2
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
1
PsiBlast_PDB
86.61
50%
-95
- C1 -
3FQ8
2
GSA_SYNP6
A:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
28
PsiBlast_CBE
86.56
50%
-95
* C1 *
3FQ7
2
GSA_SYNP6
B:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
2
PsiBlast_PDB
86.49
50%
-96
- C1 -
3FQA
3
GSA_SYNP6
A:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
106
HHSearch
86.38
49%
-91
- C1 -
3FQ8
2
GSA_SYNP6
A:
[2-426]
-
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
-
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
-----
21
PsiBlast_CBE
86.27
50%
-96
- C1 -
3FQ8
2
GSA_SYNP6
B:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
5
PsiBlast_PDB
86.26
50%
-96
- C1 -
2HP1
3
GSA_SYNP6
A:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
30
PsiBlast_CBE
86.01
50%
-95
- C1 -
3GSB
3
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
8
PsiBlast_PDB
85.97
50%
-96
- C1 -
3USF
3
GSA_SYNE7
A:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
14
PsiBlast_PDB
85.83
46%
-91
- C1 -
2E7U
4
GSA_THET8
A:
[1-420]
M
E
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
-
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
---
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
-----------
23
PsiBlast_CBE
85.82
50%
-94
- C1 -
2HP2
3
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
22
PsiBlast_CBE
85.49
50%
-96
- C1 -
3FQA
3
GSA_SYNP6
B:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
13
PsiBlast_PDB
85.29
49%
-110
- C1 -
2CFB
1
GSA_THEEB
A:
[19-411]
-----------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
E
K
G
T
S
F
G
A
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
----------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
M
V
A
P
-
A
--
G
P
-----
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
L
S
R
P
-
G
S
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
E
---
V
C
G
G
-
H
I
S
G
M
F
G
L
F
F
T
A
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
----
27
PsiBlast_CBE
82.93
50%
-103
- C1 -
3USF
3
GSA_SYNE7
B:
[19-427]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
-------------------------
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
24
PsiBlast_CBE
82.25
50%
-100
- C1 -
2HP1
3
GSA_SYNP6
B:
[24-432]
------------------
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
-
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
-----------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
-
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
---
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
----
32
PsiBlast_CBE
73.68
37%
-90
- C1 -
2ZSM
4
GSA_AERPE
C:
[12-413]
-----
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
K
---
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
----------------------
33
PsiBlast_CBE
73.29
37%
-92
- C1 -
2ZSM
4
GSA_AERPE
B:
[12-413]
-----
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
K
---
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
----------------------
17
PsiBlast_PDB
72.84
37%
-90
- C1 -
2ZSM
2
GSA_AERPE
A:
[12-413]
-----
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
K
---
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
----------------------
114
HHSearch
72.11
35%
-87
- C1 -
2EPJ
1
GSA_AERPE
A:
[9-433]
--
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
---
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
----
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
--
16
PsiBlast_PDB
71.58
37%
-89
- C1 -
2ZSL
1
GSA_AERPE
A:
[12-413]
-----
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
K
---
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
----------------------
15
PsiBlast_PDB
71.44
37%
-89
- C1 -
2EPJ
1
GSA_AERPE
A:
[12-413]
-----
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
A
V
K
---
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
V
A
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
L
E
E
E
-
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
---
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
----------------------
48
PsiBlast_CBE
69.65
31%
-99
- C1 -
4AO9
3
BFAT_VARPD
B:
[69-444]
----------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
P
T
T
V
P
----------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
------
49
PsiBlast_CBE
69.41
31%
-98
- C1 -
4AO9
2
BFAT_VARPD
A:
[69-444]
----------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
P
T
T
V
P
----------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
------
46
PsiBlast_CBE
67.98
31%
-97
- C1 -
4AOA
2
BFAT_VARPD
B:
[69-444]
----------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
P
T
T
V
P
----------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
------
109
HHSearch
67.44
31%
-90
- C1 -
2YKY
11
?
A:
[53-462]
-
D
N
P
V
S
A
G
H
H
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
----
R
P
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
L
L
N
F
A
S
G
H
--------------
A
P
T
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
R
-
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
--
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
A
F
A
E
A
L
A
D
F
I
G
E
Q
R
A
--
47
PsiBlast_CBE
67.16
31%
-97
- C1 -
4AOA
3
BFAT_VARPD
A:
[69-444]
----------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
G
G
I
N
L
T
G
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
----
V
L
G
F
G
A
R
P
S
P
T
T
V
P
----------
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
-
R
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
L
F
D
P
R
T
--
G
P
L
A
H
S
G
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
T
P
-
E
A
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
---
M
Q
F
T
-
G
I
G
S
L
M
N
A
H
F
V
Q
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
------
42
PsiBlast_CBE
61.11
32%
-91
- C1 -
2YKV
10
?
C:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
34
PsiBlast_CBE
60.98
32%
-91
- C1 -
4AO4
4
?
C:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
19
PsiBlast_PDB
60.81
32%
-90
- C1 -
2YKV
10
?
A:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
43
PsiBlast_CBE
60.34
32%
-90
- C1 -
2YKV
11
?
B:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
35
PsiBlast_CBE
60.06
32%
-90
- C1 -
4AO4
6
?
B:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
38
PsiBlast_CBE
60.02
32%
-91
- C1 -
2YKY
13
?
B:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
37
PsiBlast_CBE
59.95
32%
-91
- C1 -
2YKY
10
?
C:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
36
PsiBlast_CBE
59.94
32%
-90
- C1 -
4AO4
5
?
A:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
18
PsiBlast_PDB
59.83
32%
-90
- C1 -
2YKU
9
?
A:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
40
PsiBlast_CBE
59.82
32%
-89
- C1 -
2YKX
6
?
C:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
45
PsiBlast_CBE
59.81
32%
-90
- C1 -
2YKU
9
?
B:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
39
PsiBlast_CBE
59.75
32%
-90
- C1 -
2YKY
11
?
A:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
41
PsiBlast_CBE
59.44
32%
-90
- C1 -
2YKX
4
?
B:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
20
PsiBlast_PDB
59.42
32%
-89
- C1 -
2YKX
8
?
A:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------
44
PsiBlast_CBE
59.21
32%
-88
- C1 -
2YKU
6
?
C:
[82-447]
----------------------------------
F
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
R
K
T
V
L
A
F
D
G
G
Y
H
G
--
G
L
L
N
F
A
S
G
H
A
P
T
------------
N
A
P
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
-
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
I
Y
T
R
-
Q
A
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
---
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
-------------------