@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1755: (2016-03-28 )
LGLFDFSVKELHDKLVKKEISPFDLVSESFNRIESVEDKVGSFITLNKEAAFGVAEELGDAGIDPNNMLAGLPIGIKDNIVTKNLRTTAASKILENFDPIYDATVVSKLKNAQTINIGKLNMDEFAMGSSTETSYFHKTHNPWDLSRVPGGSSGGSASAVAAGEVLFSLGSDTGGSIRQPAAFCGVVGMKPTYGRVSRFGLIAFASSLDQIGPITKNVEDNAYLLEAISGLDANDSTSINQPVERFSDSLTGDIKGLRIGVPKEYLAEGVDPGVKQAVLDALKTLEKLGATWDEVSLPHSEYGVASYYILASSEASSNLSRFDGVRYGYRSPNATTLEELYTKTRSEGFGDEVKRRIMLGTYALSSGYYDAYYKKAQQARTLIKQDFINVFENYDVIIGPSSPTTAFKIDGMINDPITMYSNDILTVPINLAGVPAISVPCGFSDGLPVGLQIIGNYFEESLLYKVAHAFEQETTFHKEKPNL
Atome Classification :
(23 SA)
.........10........20........30......---..40......----..50........60-..---..-.....70........80........90........100.......110.......120....--...130......---.140.---......150.......160.......170.......180.......190.......200.......210.......220.......230-.......240---..--.....250.-......260..--....--.270.......280.......290.....-..300.......310.......320........330........-340.......350.......360.......370......-.380.......---390------------........400.......410...--------....420.-......430.......440.-......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LGLFDF
S
V
K
E
L
H
D
K
L
V
K
KEI
S
P
F
D
L
V
S
E
S
F
N
R
I
E
S
V
E
---
D
KVG
S
F
I
T
LN----
K
E
A
A
F
G
V
A
E
E
LGD--AG---ID-PNNMLAGLPIGIKDN
I
V
TKNL
R
T
T
A
A
S
K
I
L
E
NFDP
I
Y
D
A
T
V
V
S
K
LKNA
Q
T
I
N
IGKL
N
M
D
E
FA--MGSSTET
S
Y
F
HK---THNPW---DLSRVPGGSSGGSA
S
A
V
A
A
G
E
V
L
FSLGSDTGGSIRQ
P
A
A
F
CGVVGMKPTY
G
R
V
S
R
F
G
L
I
A
F
A
S
S
L
D
QIGPITKNVED
N
A
Y
L
L
E
A
I
SGLD-ANDSTSI
N
Q
P
---
V
E
--
R
F
S
D
SLTGD-IK
G
L
RIGV
P
K
E
--
Y
L
AE--GVDP
G
V
K
Q
A
V
L
D
A
L
K
T
L
E
K
LGATWDEVSL-PHSEYG
V
A
S
Y
Y
I
L
ASSEASSNL
S
R
-FDG
V
R
Y
GYRS-PN
A
T
T
L
E
E
-
L
Y
T
K
TRSEG
F
G
D
E
V
K
R
R
I
M
L
G
T
Y
ALSSG
Y
Y
D
A
Y
Y
K
K
A
Q
Q
-
A
R
T
L
I
K
Q
D
F
I
N
---
V
F-------------ENY
D
V
I
IGPSSP
T
T
A
F
K
IDGMIND--------P
I
T
MYSN
D
-
I
L
T
V
P
INLAGV
P
A
ISVPCGF-SDG
L
P
V
G
L
Q
I
I
G
N
Y
F
E
E
S
L
L
Y
K
V
A
H
A
F
E
QETTFHKEKPNL
5
PsiBlast_PDB
95.81
62%
-64
- C2 -
3IP4
-
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
50
HHSearch
95.23
61%
-60
- C2 -
3IP4
-
GATA_STAAM
A:
[2-485]
-
S
I
R
Y
E
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
-
L
D
--
E
L
Q
A
K
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
A
P
V
D
---
D
V
--
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
3
PsiBlast_PDB
95.17
62%
-63
- C2 -
2G5H
-
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
6
PsiBlast_PDB
94.89
62%
-62
- C2 -
2F2A
1
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
1
PsiBlast_PDB
94.67
62%
-64
- C2 -
2DF4
-
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
2
PsiBlast_PDB
94.49
62%
-64
- C2 -
2DQN
1
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
4
PsiBlast_PDB
92.51
62%
-63
- C2 -
2G5I
-
GATA_STAAM
A:
[7-479]
------
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
---
P
T
I
K
S
F
L
A
L
D
----
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
---
D
Q
-
M
D
G
K
L
F
G
I
P
M
G
I
K
D
N
I
I
T
N
G
L
E
T
T
C
A
S
K
M
L
E
G
F
V
P
I
Y
E
S
T
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
--
M
G
G
S
T
E
T
S
Y
F
K
K
---
T
V
N
P
F
---
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
A
I
S
G
A
D
-
V
N
D
S
T
S
--
A
P
---
V
D
DV
D
F
T
S
E
I
G
K
D
-
I
K
G
L
K
V
A
L
P
K
E
--
Y
L
G
E
--
G
V
A
D
D
V
K
E
A
V
Q
N
A
V
E
T
L
K
S
L
G
A
V
V
E
E
V
S
L
-
P
N
T
K
F
G
I
P
S
Y
Y
V
I
A
S
S
E
A
S
S
N
L
S
R
-
F
D
G
I
R
Y
G
Y
H
S
-
K
E
A
H
S
L
E
E
-
L
Y
K
M
S
R
S
E
G
F
G
K
E
V
K
R
R
I
F
L
G
T
F
A
L
S
S
G
Y
Y
D
A
Y
Y
K
K
S
Q
K
-
V
R
T
L
I
K
N
D
F
D
K
---
V
F
-------------
E
N
Y
D
V
V
V
G
P
T
A
P
T
T
A
F
N
L
G
E
E
I
D
D
--------
P
L
T
M
Y
A
N
D
-
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
C
G
Q
-
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
------
10
PsiBlast_PDB
91.85
49%
-58
- C2 -
4WJ3
-
GATA_PSEAE
A:
[2-481]
--
L
H
Q
L
T
L
A
E
I
A
R
A
L
A
D
K
Q
F
S
A
E
E
L
T
R
T
L
L
G
R
I
R
Q
L
D
---
P
Q
L
N
S
F
I
S
I
T
----
D
D
L
A
I
A
Q
A
K
A
A
D
E
--
R
R
---
A
N
G
E
N
G
A
L
L
G
A
P
I
A
H
K
D
L
F
C
T
Q
G
V
R
T
S
C
G
S
K
M
L
D
N
F
V
S
P
Y
D
A
T
V
V
E
K
L
T
A
A
G
A
V
T
L
G
K
L
N
M
D
E
F
A
--
M
G
S
S
N
Q
S
S
H
Y
G
A
---
V
K
N
P
W
---
S
L
D
R
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
R
L
L
P
A
A
T
G
T
D
T
G
G
S
I
R
Q
P
A
A
L
T
N
L
T
G
I
K
P
T
Y
G
R
V
S
R
W
G
M
I
A
Y
A
S
S
L
D
Q
G
G
P
L
A
R
T
A
E
D
C
A
L
M
L
G
V
M
A
G
F
D
-
P
K
D
S
T
S
V
E
Q
P
---
V
D
--
D
Y
L
A
A
L
Q
K
P
-
L
S
G
L
R
I
G
L
P
R
E
--
Y
F
G
A
--
G
L
D
S
R
I
A
D
A
V
L
A
V
V
E
E
L
K
T
L
G
A
T
V
K
D
I
S
L
-
P
N
M
Q
H
A
I
P
A
Y
Y
V
I
A
P
A
E
A
S
S
N
L
S
R
-
F
D
G
V
R
Y
G
Y
R
C
-
D
A
P
Q
N
L
E
D
-
L
Y
K
R
S
R
A
E
G
F
G
S
E
V
K
N
R
I
M
V
G
T
Y
A
L
S
A
G
Y
Y
D
A
Y
Y
L
Q
A
Q
K
-
I
R
R
L
I
K
N
D
F
V
S
---
A
F
-------------
A
E
V
D
V
I
L
G
P
T
T
P
N
P
A
W
K
I
G
E
K
N
D
D
--------
P
V
S
Q
Y
L
E
D
-
I
Y
T
I
T
A
N
L
A
G
L
P
G
L
S
M
P
A
G
F
-
V
D
G
L
P
V
G
V
Q
L
L
A
P
Y
F
Q
E
G
R
L
L
N
V
A
H
Q
Y
Q
Q
V
S
D
W
H
T
R
T
P
--
9
PsiBlast_PDB
91.17
53%
-57
- C2 -
3H0R
1
GATA_AQUAE
A:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
L
K
E
--
R
E
---
L
P
-----
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
7
PsiBlast_PDB
91.02
53%
-56
- C2 -
3H0L
-
GATA_AQUAE
A:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
L
K
E
--
R
E
---
L
P
-----
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
34
PsiBlast_CBE
90.96
53%
-58
- C2 -
3H0M
1
GATA_AQUAE
D:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
L
K
E
--
R
E
---
L
P
-----
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
8
PsiBlast_PDB
90.90
53%
-58
- C2 -
3H0M
1
GATA_AQUAE
A:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
L
K
E
--
R
E
---
L
P
-----
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
51
HHSearch
90.48
54%
-54
- C2 -
3H0L
-
GATA_AQUAE
A:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
-
L
K
--------
E
-
R
E
L
P
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
27
PsiBlast_CBE
90.08
53%
-58
- C2 -
3H0R
1
GATA_AQUAE
D:
[2-476]
--
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
---
E
K
V
K
A
Y
I
T
P
L
----
Y
G
K
A
L
K
Q
A
E
S
L
K
E
--
R
E
---
L
P
-----
L
F
G
I
P
I
A
V
K
D
N
I
L
V
E
G
E
K
T
T
C
A
S
K
I
L
E
N
F
V
A
P
Y
D
A
T
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
--
M
G
S
S
T
E
Y
S
A
F
F
P
---
T
K
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
V
I
S
G
W
D
-
E
K
D
S
T
S
A
K
V
P
---
V
P
--
E
W
S
E
E
V
K
K
E
-
V
K
G
L
K
I
G
L
P
K
E
--
F
F
E
Y
--
E
L
Q
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
E
G
F
E
I
K
E
V
S
L
-
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
A
S
S
N
L
A
R
-
Y
D
G
V
R
Y
G
Y
R
A
-
K
E
Y
K
D
I
F
E
-
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
F
A
L
S
A
G
Y
Y
D
A
Y
Y
L
K
A
Q
K
-
V
R
R
L
I
T
N
D
F
L
K
---
A
F
-------------
E
E
V
D
V
I
A
S
P
T
T
P
T
L
P
F
K
F
G
E
R
L
E
N
--------
P
I
E
M
Y
L
S
D
-
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
I
A
W
-
K
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
--
52
HHSearch
85.17
48%
-49
* C2 *
3KFU
-
GATA_THET8
E:
[2-466]
------
L
A
H
E
I
R
A
R
V
A
R
G
E
V
S
P
L
E
V
A
Q
A
Y
L
K
R
V
Q
E
L
D
---
P
G
L
G
A
F
L
S
L
N
----
E
-
R
L
L
E
E
A
E
A
-
V
D
----------
P
G
L
P
L
A
G
L
V
V
A
V
K
D
N
I
A
T
R
G
L
R
T
T
A
G
S
R
L
L
E
N
F
V
P
P
Y
E
A
T
A
V
A
R
L
K
A
L
G
A
L
V
L
G
K
T
N
L
D
E
F
G
--
M
G
S
S
T
E
H
S
A
F
F
P
---
T
K
N
P
F
---
D
P
D
R
V
P
G
G
S
S
G
G
S
A
A
A
L
A
A
D
L
A
P
L
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
A
F
C
G
V
Y
G
L
K
P
T
Y
G
R
V
S
R
F
G
L
I
A
Y
A
S
S
L
D
Q
I
G
P
M
A
R
S
V
R
D
L
A
L
L
M
D
A
A
A
G
P
D
-
P
L
D
A
T
S
L
D
L
P
---
P
R
---
F
Q
E
A
L
E
G
P
-
L
P
P
L
R
L
G
V
V
R
E
--
A
L
A
---
G
N
S
P
G
V
E
R
A
L
E
E
A
L
K
V
F
R
E
L
G
L
S
V
R
E
V
S
W
-
P
S
L
P
Q
A
L
A
A
Y
Y
I
L
A
P
A
E
A
S
S
N
L
A
R
-
Y
D
G
T
L
Y
G
R
R
A
--
A
G
E
E
V
E
G
-
M
M
E
A
T
R
-
A
L
F
G
L
E
V
K
R
R
V
L
V
G
T
F
V
L
S
S
G
Y
Y
E
A
Y
Y
G
R
A
Q
A
-
F
R
R
R
L
K
A
E
A
Q
A
---
L
F
-------------
R
E
V
D
L
L
L
L
P
T
T
P
H
P
A
F
P
F
G
A
R
R
D
---------
P
L
A
M
Y
R
E
D
-
L
Y
T
V
G
A
N
L
T
G
L
P
A
L
S
F
P
A
G
F
-
E
G
H
L
P
V
G
L
Q
L
L
A
P
W
G
E
D
E
R
L
L
R
A
A
L
A
F
E
E
A
T
A
R
A
H
L
K
A
P
-
13
PsiBlast_PDB
84.39
48%
-50
- C2 -
3KFU
-
GATA_THET8
E:
[5-459]
---------
E
I
R
A
R
V
A
R
G
E
V
S
P
L
E
V
A
Q
A
Y
L
K
R
V
Q
E
L
D
---
P
G
L
G
A
F
L
S
L
N
----
E
R
----
L
L
E
E
--
A
--
E
A
---
V
D
-
P
G
L
P
L
A
G
L
V
V
A
V
K
D
N
I
A
T
R
G
L
R
T
T
A
G
S
R
L
L
E
N
F
V
P
P
Y
E
A
T
A
V
A
R
L
K
A
L
G
A
L
V
L
G
K
T
N
L
D
E
F
G
--
M
G
S
S
T
E
H
S
A
F
F
P
---
T
K
N
P
F
---
D
P
D
R
V
P
G
G
S
S
G
G
S
A
A
A
L
A
A
D
L
A
P
L
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
A
F
C
G
V
Y
G
L
K
P
T
Y
G
R
V
S
R
F
G
L
I
A
Y
A
S
S
L
D
Q
I
G
P
M
A
R
S
V
R
D
L
A
L
L
M
D
A
A
A
G
P
D
-
P
L
D
A
T
S
L
D
L
P
----
P
--
R
F
Q
E
A
L
E
G
P
-
L
P
P
L
R
L
G
V
V
R
E
--
A
L
A
---
G
N
S
P
G
V
E
R
A
L
E
E
A
L
K
V
F
R
E
L
G
L
S
V
R
E
V
S
W
-
P
S
L
P
Q
A
L
A
A
Y
Y
I
L
A
P
A
E
A
S
S
N
L
A
R
-
Y
D
G
T
L
Y
G
R
R
A
--
A
G
E
E
V
E
G
-
M
M
E
A
T
R
A
L
-
F
G
L
E
V
K
R
R
V
L
V
G
T
F
V
L
S
S
G
Y
Y
E
A
Y
Y
G
R
A
Q
A
-
F
R
R
R
L
K
A
E
A
Q
A
---
L
F
-------------
R
E
V
D
L
L
L
L
P
T
T
P
H
P
A
F
P
F
-
G
A
R
R
D
--------
P
L
A
M
Y
R
E
D
-
L
Y
T
V
G
A
N
L
T
G
L
P
A
L
S
F
P
A
G
F
-
E
G
H
L
P
V
G
L
Q
L
L
A
P
W
G
E
D
E
R
L
L
R
A
A
L
A
F
E
E
A
T
A
--------
53
HHSearch
82.20
50%
-58
- C2 -
2GI3
6
GATA_THEMA
A:
[6-467]
-
D
F
R
K
L
T
I
E
E
C
L
K
L
S
E
---
E
E
R
E
K
L
P
Q
L
S
L
E
T
I
K
R
L
D
---
P
H
V
K
A
F
I
S
V
R
----
E
N
V
------
S
----------
V
E
-
K
K
G
K
F
W
G
I
P
V
A
I
K
D
N
I
L
T
L
G
M
R
T
T
C
A
S
R
I
L
E
N
Y
E
S
V
F
D
A
T
V
V
K
K
M
K
E
A
G
F
V
V
V
G
K
A
N
L
D
E
F
A
--
M
G
S
S
T
E
R
S
A
F
F
P
---
T
R
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
A
V
S
A
G
M
V
V
A
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
S
L
C
G
V
V
G
Y
K
P
T
Y
G
L
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
I
T
K
T
V
R
D
A
A
I
L
M
E
I
I
S
G
R
D
-
E
N
D
A
T
T
V
N
R
K
---
V
D
---
F
L
S
E
I
E
E
G
-
V
S
G
M
K
F
A
V
P
E
E
--
I
Y
E
H
--
D
I
E
E
G
V
S
E
R
F
E
E
A
L
K
L
L
E
R
L
G
A
K
V
E
R
V
K
I
-
P
H
I
K
Y
S
V
A
T
Y
Y
V
I
A
P
A
E
A
S
S
N
----------------------------
T
R
N
V
G
F
G
E
E
V
R
R
R
I
M
I
G
T
F
T
L
S
A
A
Y
Y
E
A
Y
F
N
K
A
M
K
-
V
R
R
K
I
S
D
E
L
N
E
---
V
L
-------------
S
Q
Y
D
A
I
L
T
P
T
S
P
V
T
A
F
K
I
G
E
I
K
D
---------
P
L
T
Y
Y
L
M
D
-
I
F
T
I
P
A
N
L
A
G
L
P
A
I
S
V
P
F
G
F
-
S
N
N
L
P
V
G
V
Q
V
I
G
R
R
F
A
D
G
K
V
F
R
I
A
R
A
I
E
K
N
S
P
Y
N
E
N
G
---
11
PsiBlast_PDB
81.36
52%
-54
- C2 -
3AL0
-
GATA_THEMA
A:
[29-464]
----------------------------
S
L
E
T
I
K
R
L
D
---
P
H
V
K
A
F
I
S
V
R
----
E
-----------
N
--
V
S
---
V
E
-
K
K
G
K
F
W
G
I
P
V
A
I
K
D
N
I
L
T
L
G
M
R
T
T
C
A
S
R
I
L
E
N
Y
E
S
V
F
D
A
T
V
V
K
K
M
K
E
A
G
F
V
V
V
G
K
A
N
L
D
E
F
A
--
M
G
S
S
T
E
R
S
A
F
F
P
---
T
R
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
A
V
S
A
G
M
V
V
A
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
S
L
C
G
V
V
G
Y
K
P
T
Y
G
L
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
I
T
K
T
V
R
D
A
A
I
L
M
E
I
I
S
G
R
D
-
E
N
D
A
T
T
V
N
R
K
---
V
D
--
F
L
S
E
I
E
E
G
--
V
S
G
M
K
F
A
V
P
E
E
--
I
Y
E
H
--
D
I
E
E
G
V
S
E
R
F
E
E
A
L
K
L
L
E
R
L
G
A
K
V
E
R
V
K
I
-
P
H
I
K
Y
S
V
A
T
Y
Y
V
I
A
P
A
E
A
S
S
N
L
A
R
-
F
D
G
V
K
Y
G
L
R
I
--
K
E
K
G
L
R
E
-
M
Y
M
K
T
R
N
V
G
F
G
E
E
V
R
R
R
I
M
I
G
T
F
T
L
S
A
A
Y
Y
E
A
Y
F
N
K
A
M
K
-
V
R
R
K
I
S
D
E
L
N
E
---
V
L
-------------
S
Q
Y
D
A
I
L
T
P
T
S
P
V
T
A
F
K
I
-
G
E
I
K
D
--------
P
L
T
Y
Y
L
M
D
-
I
F
T
I
P
A
N
L
A
G
L
P
A
I
S
V
P
F
G
F
-
S
N
N
L
P
V
G
V
Q
V
I
G
R
R
F
A
D
G
K
V
F
R
I
A
R
A
I
E
K
N
S
P
Y
N
E
-----
12
PsiBlast_PDB
80.24
51%
-56
- C2 -
2GI3
6
GATA_THEMA
A:
[30-465]
----------------------------
S
L
E
T
I
K
R
L
D
---
P
H
V
K
A
F
I
S
V
R
----
E
-----------
N
--
V
S
---
V
E
-
K
K
G
K
F
W
G
I
P
V
A
I
K
D
N
I
L
T
L
G
M
R
T
T
C
A
S
R
I
L
E
N
Y
E
S
V
F
D
A
T
V
V
K
K
M
K
E
A
G
F
V
V
V
G
K
A
N
L
D
E
F
A
--
M
G
S
S
T
E
R
S
A
F
F
P
---
T
R
N
P
W
---
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
A
V
S
A
G
M
V
V
A
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
S
L
C
G
V
V
G
Y
K
P
T
Y
G
L
V
S
R
Y
G
L
V
A
F
A
S
S
L
D
Q
I
G
P
I
T
K
T
V
R
D
A
A
I
L
M
E
I
I
S
G
R
D
-
E
N
D
A
T
T
V
N
R
K
---
V
D
--
F
L
S
E
I
E
E
G
--
V
S
G
M
K
F
A
V
P
E
E
--
I
Y
E
H
--
D
I
E
E
G
V
S
E
R
F
E
E
A
L
K
L
L
E
R
L
G
A
K
V
E
R
V
K
I
-
P
H
I
K
Y
S
V
A
T
Y
Y
V
I
A
P
A
E
A
S
S
N
----------------------------
T
R
N
V
G
F
G
E
E
V
R
R
R
I
M
I
G
T
F
T
L
S
A
A
Y
Y
E
A
Y
F
N
K
A
M
K
-
V
R
R
K
I
S
D
E
L
N
E
---
V
L
-------------
S
Q
Y
D
A
I
L
T
P
T
S
P
V
T
A
F
K
I
-
G
E
I
K
D
--------
P
L
T
Y
Y
L
M
D
-
I
F
T
I
P
A
N
L
A
G
L
P
A
I
S
V
P
F
G
F
-
S
N
N
L
P
V
G
V
Q
V
I
G
R
R
F
A
D
G
K
V
F
R
I
A
R
A
I
E
K
N
S
P
Y
N
E
-----
19
PsiBlast_PDB
78.75
31%
-48
- C2 -
1M21
1
?
A:
[13-488]
-------
V
A
D
L
Q
A
R
M
T
A
G
E
L
D
S
T
T
L
T
Q
A
Y
L
Q
R
I
A
A
L
D
RTG
P
R
L
R
A
V
I
E
L
N
PD
A
L
K
E
A
A
E
R
D
R
E
R
R
D
G
--
R
L
---
R
G
-
P
---
L
H
G
I
P
L
L
L
K
D
N
I
N
A
A
P
M
A
T
S
A
G
S
L
A
L
Q
G
F
R
P
-
D
D
A
Y
L
V
R
R
L
R
D
A
G
A
V
V
L
G
K
T
N
L
S
E
W
A
NF
R
G
N
D
S
I
S
G
W
S
A
R
G
G
Q
T
R
N
P
Y
---
R
I
S
H
S
P
C
G
S
S
S
G
S
A
V
A
V
A
A
N
L
A
S
V
A
I
G
T
E
T
D
G
S
I
V
C
P
A
A
I
N
G
V
V
G
L
K
P
T
V
G
L
V
S
R
D
G
I
I
P
I
S
F
S
Q
D
T
A
G
P
M
A
R
S
V
A
D
A
A
A
V
L
T
A
I
A
G
R
D
-
D
A
D
P
A
T
A
T
M
P
GRA
V
Y
--
D
Y
T
A
R
L
D
P
Q
G
L
R
G
K
R
I
G
L
L
Q
T
--
P
L
L
K
YR
G
M
P
P
L
I
E
Q
A
A
T
E
----
L
R
R
A
G
A
V
V
V
P
V
E
L
-
P
N
Q
G
A
W
A
E
A
E
R
T
L
L
L
Y
E
F
K
A
G
L
E
R
Y
F
N
T
H
R
A
P
L
R
S
L
A
D
L
I
A
F
N
Q
-
A
H
S
K
Q
E
L
G
L
F
G
Q
E
-----
L
L
V
E
A
D
A
T
A
G
L
A
D
P
A
Y
I
R
A
R
S
D
A
R
R
L
A
G
P
E
G
I
D
A
A
L
A
A
-------------
H
Q
L
D
A
L
V
A
P
T
T
-
G
V
A
W
P
I
R
S
E
G
D
D
F-------
P
G
E
S
Y
S
A
-------
A
A
V
A
G
Y
P
S
L
T
V
P
M
G
Q
-
I
D
G
L
P
V
G
L
L
F
M
G
T
A
W
S
E
P
K
L
I
E
M
A
Y
A
Y
E
Q
R
T
R
A
R
R
-----
15
PsiBlast_PDB
75.59
36%
-51
- C2 -
4N0I
2
GATA_YEAST
A:
[7-454]
-------------------------
L
K
E
S
I
E
R
L
S
S
F
Q
---
S
K
Y
N
I
F
T
S
I
N
-----
P
S
P
Y
S
--------------------
T
L
T
G
C
V
A
S
I
K
D
N
I
V
T
K
D
F
P
T
T
C
A
S
H
I
L
E
N
F
K
S
P
F
D
A
T
V
V
K
L
L
K
Q
A
G
V
H
I
L
G
K
T
N
L
D
E
F
G
--
M
G
S
G
G
V
H
S
I
R
G
P
---
V
I
N
P
L
YPH
E
D
K
K
I
M
G
G
S
S
S
G
A
A
A
S
V
A
C
D
L
V
D
F
A
L
G
T
D
T
G
G
S
V
R
L
P
A
C
Y
G
S
V
L
G
F
K
P
S
Y
G
R
L
S
R
F
G
V
I
A
Y
S
Q
S
L
D
T
V
G
I
L
S
K
K
I
N
V
L
R
K
V
F
H
T
L
D
K
Y
D
-
M
K
D
P
T
S
L
S
V
E
---
L
R
--
E
L
I
E
G
N
K
K
V
-
R
R
P
L
K
V
G
I
V
K
E
--
F
S
H
E
--
S
M
P
I
G
F
H
R
L
Y
L
S
L
L
E
K
L
I
N
L
G
L
E
I
Y
P
V
S
I
-
P
S
V
K
N
C
L
P
I
Y
Y
T
L
S
P
A
E
A
A
S
N
L
S
R
-
Y
D
G
I
R
Y
G
Y
R
D
-
S
E
L
D
I
K
D
G
I
L
F
A
P
T
R
S
K
-
F
G
T
E
V
K
N
R
I
I
L
G
N
Y
N
L
C
S
D
A
F
K
N
N
F
I
K
A
E
K
-
L
R
V
N
L
I
D
E
F
D
G
---
I
F
RFPNVLTNSKGNP
D
G
L
D
L
L
I
V
P
----
T
S
S
K
L
P
G
S
I
R
D
F
E
E
E
E
A
K
S
P
A
N
S
Y
I
N
D
-
V
F
T
V
P
M
S
L
A
G
L
P
S
L
S
M
P
--
L
-
K
E
K
T
P
I
G
L
Q
V
V
G
Q
Y
G
D
D
S
----------------------
49
PsiBlast_CBE
61.41
31%
-38
- C2 -
4IST
1
?
A:
[94-470]
---------------------------------------------------------------------------------
L
Y
G
V
P
I
A
V
K
D
N
I
D
Y
K
G
L
P
T
T
A
A
C
P
S
Y
L
-
Y
Q
P
T
R
D
S
Y
V
V
E
L
L
R
D
A
G
A
V
V
I
G
K
T
N
L
D
Q
F
A
--
T
G
L
V
G
T
R
S
P
Y
G
K
---
T
P
C
V
F
---
N
D
K
Y
V
S
G
G
S
S
A
G
S
A
S
V
V
G
R
G
I
V
P
L
S
L
G
T
D
T
A
G
A
G
R
V
P
A
A
L
N
N
L
I
G
L
K
P
T
K
G
A
F
S
C
R
G
V
V
P
A
C
K
S
L
D
C
V
S
V
F
A
L
N
L
S
D
A
E
I
A
F
K
V
M
N
K
P
D
L
L
E
D
E
Y
S
R
E
F
P
---------
K
N
P
I
S
Q
Y
-
P
K
D
L
T
I
A
I
P
K
E
VP
W
F
G
E
--
T
E
N
P
---
K
L
Y
T
K
A
V
A
S
L
K
N
T
G
A
K
I
V
V
V
D
F
E
P
L
L
E
L
A
R
C
L
Y
------
E
G
A
W
V
A
E
R
-
Y
C
A
T
R
-------------
D
-
F
L
A
T
N
P
P
E
S
S
L
D
E
T
V
V
N
I
I
K
G
A
V
K
F
D
A
A
--
D
A
F
--
K
F
E
Y
-
K
R
Q
G
I
L
Q
K
V
N
L
---
L
L
-------------
K
D
I
D
V
L
C
V
P
T
C
P
L
N
P
-
K
L
E
E
V
A
Q
E
--------
P
V
L
V
N
S
R
Q
G
T
W
T
N
F
V
N
L
A
D
L
A
A
L
A
V
P
S
G
F
R
S
D
G
L
P
N
G
I
T
L
I
G
K
K
F
S
D
Y
A
L
L
D
L
A
K
R
F
-------------
48
PsiBlast_CBE
60.76
31%
-37
- C2 -
4IST
1
?
B:
[94-470]
---------------------------------------------------------------------------------
L
Y
G
V
P
I
A
V
K
D
N
I
D
Y
K
G
L
P
T
T
A
A
C
P
S
Y
L
-
Y
Q
P
T
R
D
S
Y
V
V
E
L
L
R
D
A
G
A
V
V
I
G
K
T
N
L
D
Q
F
A
--
T
G
L
V
G
T
R
S
P
Y
G
K
---
T
P
C
V
F
---
N
D
K
Y
V
S
G
G
S
S
A
G
S
A
S
V
V
G
R
G
I
V
P
L
S
L
G
T
D
T
A
G
A
G
R
V
P
A
A
L
N
N
L
I
G
L
K
P
T
K
G
A
F
S
C
R
G
V
V
P
A
C
K
S
L
D
C
V
S
V
F
A
L
N
L
S
D
A
E
I
A
F
K
V
M
N
K
P
D
L
L
E
D
E
Y
S
R
E
F
P
---------
K
N
P
I
S
Q
Y
-
P
K
D
L
T
I
A
I
P
K
E
VP
W
F
G
E
--
T
E
N
P
---
K
L
Y
T
K
A
V
A
S
L
K
N
T
G
A
K
I
V
V
V
D
F
E
P
L
L
E
L
A
R
C
L
Y
------
E
G
A
W
V
A
E
R
-
Y
C
A
T
R
-------------
D
-
F
L
A
T
N
P
P
E
S
S
L
D
E
T
V
V
N
I
I
K
G
A
V
K
F
D
A
A
--
D
A
F
--
K
F
E
Y
-
K
R
Q
G
I
L
Q
K
V
N
L
---
L
L
-------------
K
D
I
D
V
L
C
V
P
T
C
P
L
N
P
-
K
L
E
E
V
A
Q
E
--------
P
V
L
V
N
S
R
Q
G
T
W
T
N
F
V
N
L
A
D
L
A
A
L
A
V
P
S
G
F
R
S
D
G
L
P
N
G
I
T
L
I
G
K
K
F
S
D
Y
A
L
L
D
L
A
K
R
F
-------------