@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1837: (2016-03-29 )
MYVLKNGQVLNASGKLESKDVLIQNGKVNLIADSIEVTSGEEFDATGKLITPGFIDVHVHLREPGGEHKETILTGTKAAARGGYTTICSMPNTKPVPDSKEVMESIQAKIKETAKVRVLPYASITTSLGTDELVDFEALKEAGAFAFTDDGVGVQLAGTMYEAMKRAAALDMAIVAHCEDNSLIYGGVVHDGIFAEKEGLKGIPNIAESVQIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVSPHHLILDEEAIPGNDGNWKMNPPLRSKEDRAALLEGLLDGTIDFIATDHAPHAAEEKNVPMEQAAFGIVGLETAFPLLYTHFVKTNEWTLKQLIDWMTVKPAECFKLPYGKLEEGSVADIVVLDLEKEANIDPDTFYSKGKNTPFVGETCIGWPVATFAEGTLVYNEGEIK
Atome Classification :
(20 SA)
-.........10...-.....-20........30..--....--..40.---.-......50........60...--.....70........80........90-....-....100........110....-------------..--.-120...-------------....130.......140.....--------.---.150------.-.....--.160.......170.......180.---.---.---...---.190.......-----200.......210....------...220-----........230.......240.......250.......260.........270-....----..----...280.......290.......300.....----..310.-.---..---...320.......330.......340.......350.......360--.--......370.......380.......390.......400.......410.......420....-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
Y
V
LKN
G
Q
V
LNASG-KLES
K
-
D
V
L
I
QNG
K
V
N
L
I
A
D
--
S
I
E
V--TSGEE---F-DATGKLITP
G
F
I
D
V
H
V
H
L
REP--GGE
H
K
E
T
I
LTGTKAAARGG
Y
T
T
I
CSMP-NTKP-VP
D
S
K
-
E
V
M
E
S
I
Q
A
K
I
K
ET
A
K
V
-------------
R
V
--
L
-
P
Y
A
S
I
T-------------TSLGTDELV
D
F
E
A
L
K
EAG
A
F
A
F--------T---DDGV------
G
-
V
Q
L
A
G
--
T
M
Y
E
A
M
K
R
A
A
A
L
D
M
A
I
V
A
HCEDN
S
L
---
I
---
Y
---
G
G
V---VHDGIFAEKEG-----LKGI
P
N
I
A
E
S
V
Q
I
A
R
D
V
------
L
L
A
EA------AG
C
H
Y
H
V
C
H
IS
T
K
E
S
V
R
V
V
R
DAKRA
G
I
R
V
T
A
EVSP
H
H
L
I
--
L
DEEAIPGND---GNWK----MN----PPLRS
K
E
D
R
A
A
L
L
E
G
L
L
DGT
I
D
F
I
ATDHAPH----AAEEKN-V---
P
M
---
E
Q
A
A
FGIV
G
L
E
T
A
F
P
L
L
Y
T
H
FVKTN
E
W
T
L
K
Q
L
I
D
W
MTV
K
P
A
E
C
FKL--P--YGKLEEG
S
V
A
D
I
V
V
L
DLEKEANIDP
D
T
FYSKGKNTPFVGETCIGWP
V
A
T
FAE
G
T
L
V
YNEGEIK-------------------------------------
115
HHSearch
99.08
64%
-82
- C2 -
3GRI
5
PYRC_STAAW
A:
[1-422]
-
M
K
L
I
K
N
G
K
V
L
Q
N
-
G
-
E
L
Q
Q
A
-
D
I
L
I
D
G
K
V
I
K
Q
I
A
P
--
A
I
E
P
S
-
N
G
V
D
I
---
I
-
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
--
G
G
E
Y
K
E
T
I
E
T
G
T
K
A
A
A
R
G
G
F
T
T
V
C
P
M
P
-
N
T
R
P
-
V
P
D
S
V
-
E
H
F
E
A
L
Q
K
L
I
D
D
N
A
Q
V
-------------
R
V
--
L
-
P
Y
A
S
I
T
-------------
T
R
Q
L
G
K
E
L
V
D
F
P
A
L
V
K
E
G
A
F
A
F
--------
T
---
D
D
G
V
------
G
-
V
Q
T
A
S
--
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
L
---
I
---
Y
---
G
G
A
---
M
H
E
G
K
R
S
K
E
L
G
-----
I
P
G
I
P
N
I
C
E
S
V
Q
I
A
R
D
V
------
L
L
A
E
A
------
A
G
C
H
Y
H
V
C
H
V
S
T
K
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
H
H
L
L
--
L
T
E
D
D
I
P
G
N
N
---
A
I
Y
K
----
M
N
----
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
----
A
R
D
E
K
A
-
Q
---
P
M
---
E
K
A
P
F
G
I
V
G
S
E
T
A
F
P
L
L
Y
T
H
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
T
I
K
P
C
E
T
F
N
L
--
E
--
Y
G
T
L
K
E
N
G
Y
A
D
L
T
I
I
D
L
D
S
E
Q
E
I
K
G
E
D
F
L
S
K
A
D
N
T
P
F
I
G
Y
K
V
Y
G
N
P
I
L
T
M
V
E
G
E
V
K
F
E
G
-----------------------------------------
2
PsiBlast_PDB
97.88
63%
-81
- C2 -
3GRI
5
PYRC_STAAW
A:
[3-420]
---
L
I
K
N
G
K
V
L
Q
-
N
G
-
E
L
Q
Q
A
-
D
I
L
I
D
G
K
V
I
K
Q
I
A
P
--
A
I
E
P
--
S
N
G
V
D
---
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
--
G
G
E
Y
K
E
T
I
E
T
G
T
K
A
A
A
R
G
G
F
T
T
V
C
P
M
P
-
N
T
R
P
-
V
P
D
S
V
-
E
H
F
E
A
L
Q
K
L
I
D
D
N
A
Q
V
-------------
R
V
--
L
-
P
Y
A
S
I
T
-------------
T
R
Q
L
G
K
E
L
V
D
F
P
A
L
V
K
E
G
A
F
A
F
--------
T
---
D
D
G
V
------
G
-
V
Q
T
A
S
--
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
L
---
I
---
Y
---
G
G
A
---
M
H
E
G
K
R
S
K
E
L
G
-----
I
P
G
I
P
N
I
C
E
S
V
Q
I
A
R
D
V
------
L
L
A
E
A
------
A
G
C
H
Y
H
V
C
H
V
S
T
K
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
H
H
L
L
--
L
T
E
D
D
I
P
G
N
N
---
A
I
Y
K
----
M
N
----
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
----
A
R
D
E
K
A
-
Q
---
P
M
---
E
K
A
P
F
G
I
V
G
S
E
T
A
F
P
L
L
Y
T
H
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
T
I
K
P
C
E
T
F
N
L
--
E
--
Y
G
T
L
K
E
N
G
Y
A
D
L
T
I
I
D
L
D
S
E
Q
E
I
K
G
E
D
F
L
S
K
A
D
N
T
P
F
I
G
Y
K
V
Y
G
N
P
I
L
T
M
V
E
G
E
V
K
F
-------------------------------------------
116
HHSearch
96.41
63%
-80
- C2 -
3MPG
2
PYRC_BACAN
A:
[2-426]
-
N
Y
L
F
K
N
G
R
Y
M
N
E
E
G
-
K
I
V
A
T
-
D
L
L
V
Q
D
G
K
I
A
K
V
A
E
--
N
I
T
A
--
D
N
A
E
V
---
I
-
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
A
M
P
-
N
T
R
P
-
V
P
D
C
R
-
E
H
M
E
D
L
Q
N
R
I
K
E
K
A
H
V
-------------
N
V
--
L
-
P
Y
G
A
I
T
-------------
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
E
L
G
A
F
A
F
--------
T
---
D
D
G
V
------
G
-
V
Q
D
A
S
--
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
L
---
I
---
N
---
K
G
C
---
V
H
E
G
K
F
S
E
K
H
G
-----
L
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
--
L
C
E
D
D
I
P
S
A
D
---
P
N
F
K
----
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
----
T
A
E
E
K
A
-
Q
---
G
I
---
E
R
A
P
F
G
I
T
G
F
E
T
A
F
P
L
L
Y
T
N
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
T
E
K
P
A
D
T
F
G
L
--
E
--
A
G
R
L
K
E
G
R
T
A
D
I
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
W
P
V
M
T
I
V
G
G
K
I
A
W
Q
K
E
S
A
--------------------------------------
1
PsiBlast_PDB
96.00
63%
-80
- C2 -
3MPG
2
PYRC_BACAN
A:
[3-423]
--
Y
L
F
K
N
G
R
Y
M
N
E
E
G
-
K
I
V
A
T
-
D
L
L
V
Q
D
G
K
I
A
K
V
A
E
--
N
I
T
A
--
D
N
A
E
V
---
I
-
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
A
M
P
-
N
T
R
P
-
V
P
D
C
R
-
E
H
M
E
D
L
Q
N
R
I
K
E
K
A
H
V
-------------
N
V
--
L
-
P
Y
G
A
I
T
-------------
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
E
L
G
A
F
A
F
--------
T
---
D
D
G
V
------
G
-
V
Q
D
A
S
--
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
L
---
I
---
N
---
K
G
C
---
V
H
E
G
K
F
S
E
K
H
G
-----
L
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
--
L
C
E
D
D
I
P
S
A
D
---
P
N
F
K
----
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
----
T
A
E
E
K
A
-
Q
---
G
I
---
E
R
A
P
F
G
I
T
G
F
E
T
A
F
P
L
L
Y
T
N
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
T
E
K
P
A
D
T
F
G
L
--
E
--
A
G
R
L
K
E
G
R
T
A
D
I
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
W
P
V
M
T
I
V
G
G
K
I
A
W
Q
K
-----------------------------------------
21
PsiBlast_CBE
95.86
63%
-80
- C2 -
3MPG
2
PYRC_BACAN
B:
[3-423]
--
Y
L
F
K
N
G
R
Y
M
N
E
E
G
-
K
I
V
A
T
-
D
L
L
V
Q
D
G
K
I
A
K
V
A
E
--
N
I
T
A
--
D
N
A
E
V
---
I
-
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
A
M
P
-
N
T
R
P
-
V
P
D
C
R
-
E
H
M
E
D
L
Q
N
R
I
K
E
K
A
H
V
-------------
N
V
--
L
-
P
Y
G
A
I
T
-------------
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
E
L
G
A
F
A
F
--------
T
---
D
D
G
V
------
G
-
V
Q
D
A
S
--
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
L
---
I
---
N
---
K
G
C
---
V
H
E
G
K
F
S
E
K
H
G
-----
L
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
--
L
C
E
D
D
I
P
S
A
D
---
P
N
F
K
----
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
----
T
A
E
E
K
A
-
Q
---
G
I
---
E
R
A
P
F
G
I
T
G
F
E
T
A
F
P
L
L
Y
T
N
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
T
E
K
P
A
D
T
F
G
L
--
E
--
A
G
R
L
K
E
G
R
T
A
D
I
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
W
P
V
M
T
I
V
G
G
K
I
A
W
Q
K
-----------------------------------------
3
PsiBlast_PDB
86.77
42%
-75
- C2 -
3D6N
2
PYRC_AQUAE
A:
[5-422]
---
I
V
K
N
G
Y
V
I
D
P
S
Q
-
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
L
---
A
---
Y
----
G
V
---
I
N
E
G
E
V
S
A
L
L
G
-----
L
S
S
R
A
P
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
--
F
T
E
R
E
V
L
N
S
G
---
A
N
A
R
----
V
N
----
P
P
L
R
K
K
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
F
E
K
E
-
L
----
V
---
E
F
A
M
P
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
L
Y
R
K
-
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
6
PsiBlast_PDB
86.10
42%
-72
- C2 -
4BJH
6
PYRC_AQUAE
A:
[39-456]
---
I
V
K
N
G
Y
V
I
D
P
S
Q
-
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
A
C
E
D
D
K
L
---
A
---
Y
----
G
V
---
I
N
E
G
E
V
S
A
L
L
G
-----
L
S
S
R
A
P
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
A
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
--
F
T
E
R
E
V
L
N
S
G
---
A
N
A
R
----
V
N
----
P
P
L
R
K
K
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
F
E
K
E
-
L
----
V
---
E
F
A
M
P
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
L
Y
R
K
-
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
119
HHSearch
83.66
43%
-67
- C2 -
2Z00
2
?
A:
[1-426]
-
M
I
L
I
R
N
V
R
L
V
D
A
R
G
-
E
R
G
P
A
-
D
V
L
I
G
E
G
R
I
L
S
L
E
G
--
G
E
-----
A
K
Q
V
---
V
-
D
G
T
G
C
F
L
A
P
G
F
L
D
L
H
A
H
L
R
E
P
--
G
E
E
V
K
E
D
L
F
S
G
L
L
A
A
V
R
G
G
Y
T
D
L
V
S
M
P
-
N
T
K
P
-
P
V
D
T
P
-
E
A
V
R
A
L
K
E
K
A
K
A
L
G
L
A
-------------
R
L
--
H
-
P
A
A
A
L
T
-------------
E
K
Q
E
G
K
T
L
T
P
A
G
L
L
R
E
A
G
A
V
L
L
--------
T
---
D
D
G
R
------
T
-
N
E
D
A
G
--
V
L
A
A
G
L
L
M
A
A
P
L
G
L
P
V
A
V
H
A
E
D
A
G
L
---
R
---
R
---
N
G
V
---
M
N
D
G
P
L
A
D
L
L
G
-----
L
P
G
N
P
P
E
A
E
A
A
R
I
A
R
D
L
------
E
V
L
R
Y
A
L
R
R
SP
A
T
P
R
L
H
V
Q
H
L
S
T
K
R
G
L
E
L
V
R
E
A
K
R
A
G
L
P
V
T
A
E
A
T
P
H
H
L
T
--
L
T
E
E
A
L
R
T
F
D
---
P
L
F
K
----
V
A
----
P
P
L
R
G
E
E
D
R
E
A
L
L
E
G
L
L
D
G
T
L
D
A
I
A
T
D
H
A
P
H
----
T
L
A
E
K
E
-
K
---
D
L
---
L
R
A
P
F
G
I
P
S
L
E
V
A
F
P
L
L
Y
T
E
L
H
L
K
R
G
F
P
L
Q
R
L
V
E
L
F
T
D
G
P
R
R
V
L
G
L
--
P
--
P
L
H
L
E
E
G
A
E
A
S
L
V
L
L
S
P
K
E
R
P
-
V
D
P
S
A
F
A
S
K
A
R
Y
S
P
W
A
G
W
V
L
G
G
W
P
V
L
T
L
V
A
G
R
I
V
H
E
A
L
K
---------------------------------------
125
HHSearch
82.18
42%
-84
* C2 *
1XRT
1
PYRC_AQUAE
A:
[48-467]
-
K
L
I
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
-
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
L
---
A
-------
Y
----------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
-----------------------------------
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
-------------------
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
5
PsiBlast_PDB
82.00
42%
-84
- C2 -
1XRT
1
PYRC_AQUAE
A:
[50-467]
---
I
V
K
N
G
Y
V
I
D
P
S
Q
-
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
L
---
A
---
Y
--------------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
-----------------------------------
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
-------------------
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
L
Y
R
K
-
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
4
PsiBlast_PDB
81.88
42%
-87
- C2 -
1XRF
2
PYRC_AQUAE
A:
[50-467]
---
I
V
K
N
G
Y
V
I
D
P
S
Q
-
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
----------------------------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
------------------------------------
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
-----------------
M
P
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
L
Y
R
K
-
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
22
PsiBlast_CBE
81.33
42%
-86
- C2 -
1XRT
1
PYRC_AQUAE
B:
[50-467]
---
I
V
K
N
G
Y
V
I
D
P
S
Q
-
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
I
D
K
--
N
I
L
V
--
P
E
A
E
I
---
I
-
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
C
M
P
-
N
T
N
P
-
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
K
S
K
S
V
G
L
C
-------------
R
V
--
L
-
P
T
G
T
I
T
-------------
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
E
A
G
C
V
A
F
--------
T
---
D
D
G
S
------
P
-
V
M
D
S
S
--
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
L
---
A
-----------------------------------
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
-------------------------------------
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
----
Q
T
------------------
P
G
I
I
G
L
Q
T
A
L
P
S
A
L
E
L
Y
R
K
-
G
I
I
S
L
K
K
L
I
E
M
F
T
I
N
P
A
R
I
I
G
V
--
D
--
L
G
T
L
K
L
G
S
P
A
D
I
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
D
G
K
M
V
Y
K
D
-----------------------------------------
7
PsiBlast_PDB
80.74
42%
-66
- C2 -
2Z00
2
?
A:
[3-422]
---
L
I
R
N
V
R
L
V
D
A
R
G
-
E
R
G
P
A
-
D
V
L
I
G
E
G
R
I
--------
L
S
L
--
E
G
G
E
A
KQV
V
-
D
G
T
G
C
F
L
A
P
G
F
L
D
L
H
A
H
L
R
E
P
--
G
E
E
V
K
E
D
L
F
S
G
L
L
A
A
V
R
G
G
Y
T
D
L
V
S
M
P
-
N
T
K
P
-
P
V
D
T
P
-
E
A
V
R
A
L
K
E
K
A
K
A
L
G
L
A
-------------
R
L
--
H
-
P
A
A
A
L
T
-------------
E
K
Q
E
G
K
T
L
T
P
A
G
L
L
R
E
A
G
A
V
L
L
--------
T
---
D
D
G
R
------
T
-
N
E
D
A
G
--
V
L
A
A
G
L
L
M
A
A
P
L
G
L
P
V
A
V
H
A
E
D
A
G
L
---
R
---
R
---
N
G
V
---
M
N
D
G
P
L
A
D
L
L
G
-----
L
P
G
N
P
P
E
A
E
A
A
R
I
A
R
D
L
E
V
L
R
Y
A
L
R
R
S
P
------
A
T
P
R
L
H
V
Q
H
L
S
T
K
R
G
L
E
L
V
R
E
A
K
R
A
G
L
P
V
T
A
E
A
T
P
H
H
L
T
--
L
T
E
E
A
L
R
T
F
D
---
P
L
F
K
----
V
A
----
P
P
L
R
G
E
E
D
R
E
A
L
L
E
G
L
L
D
G
T
L
D
A
I
A
T
D
H
A
P
H
----
T
L
A
E
K
E
-
K
---
D
L
---
L
R
A
P
F
G
I
P
S
L
E
V
A
F
P
L
L
Y
T
E
L
H
L
K
R
G
F
P
L
Q
R
L
V
E
L
F
T
D
G
P
R
R
V
L
G
L
--
P
--
P
L
H
L
E
E
G
A
E
A
S
L
V
L
L
S
-
P
K
E
R
P
V
D
P
S
A
F
A
S
K
A
R
Y
S
P
W
A
G
W
V
L
G
G
W
P
V
L
T
L
V
A
G
R
I
V
H
-------------------------------------------
107
Fugue
75.67
28%
-72
- C2 -
4TQT
8
?
A:
[14-490]
A
S
K
V
I
K
G
G
T
V
I
T
A
D
R
-
T
F
R
A
--
D
I
L
I
E
D
G
K
I
A
A
I
G
D
--
S
L
E
----
G
D
E
V
---
I
-
D
A
S
G
C
Y
V
M
P
G
G
I
D
P
H
T
H
L
Q
M
P
FM
G
T
Y
S
S
D
D
F
D
T
G
T
A
A
A
L
A
G
G
T
T
M
V
V
D
F
V
------
L
P
D
S
E
G
N
L
L
D
A
L
Q
E
W
F
Q
K
A
G
K
A
-------------
R
T
--
D
-
Y
S
F
H
M
A
I
------------
T
G
W
N
E
R
T
F
N
E
M
A
E
V
V
K
R
G
I
N
T
F
--------
H
FMA
Y
K
G
A
------
L
-
M
V
N
D
D
--
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
M
P
L
V
H
A
E
N
G
D
I
---
V
--------
A
Q
---
L
Q
A
K
L
M
A
E
G
N
D
G
P
E
A
H
A
Y
S
R
P
P
E
V
E
G
E
A
T
N
R
A
I
------
M
I
A
D
Q
------
A
G
V
P
L
Y
V
V
H
V
S
C
E
Q
S
H
E
A
I
R
R
A
R
Q
K
G
M
R
V
F
G
E
P
L
I
Q
H
L
T
--
L
D
E
S
E
Y
H
N
R
D
---
W
D
Y
A
----
A
R
R
VMS
P
P
F
R
D
K
L
N
Q
D
S
L
W
A
G
L
A
A
G
S
L
Q
C
V
A
T
D
H
C
A
F
----
T
T
E
Q
K
R
-
Y
GIG
N
F
---
T
K
I
P
N
G
T
G
G
L
E
E
R
M
P
V
L
W
T
R
G
V
R
T
G
R
L
T
P
N
E
F
V
A
V
T
S
T
N
I
A
K
I
L
N
I
YP
Q
--
K
G
A
V
V
P
G
A
D
A
D
L
V
I
W
D
P
E
T
T
K
K
I
S
A
K
T
Q
H
S
S
I
D
Y
N
V
F
E
G
F
E
L
K
G
L
P
I
M
T
L
S
R
G
R
I
A
F
D
K
G
Q
V
T
AKPGD
G
R
F
I
E
R
E
P
NG
A
V
N
R
A
L
S
Q
W
K
E
I
V
A
P
R
K
V
E
R
S
A
124
HHSearch
74.73
25%
-64
- C2 -
3HM7
1
ALLB_BACHD
A:
[7-440]
-
D
L
I
I
R
S
S
T
V
V
T
E
T
T
--
T
Y
R
A
-
D
V
A
I
R
N
G
I
V
S
A
I
T
E
--
P
G
S
I
SS
D
D
G
P
A
---
I
-
D
G
T
G
L
H
L
F
P
G
M
V
D
V
H
V
H
F
N
E
P
--
G
R
T
E
W
E
G
F
A
S
G
S
K
S
L
A
A
G
G
V
T
T
Y
F
D
M
P
-
L
N
S
N
P
P
T
I
T
R
-
E
E
L
D
K
K
R
Q
L
A
N
E
K
S
L
V
-------------
D
Y
--
R
-
F
W
G
G
L
V
-------------
P
----
G
N
I
D
H
L
Q
D
L
H
D
G
G
V
I
G
F
--------
K
---
A
F
M
S
ECGTDD
F
Q
F
S
H
D
E
--
T
L
L
K
G
M
K
K
I
A
A
L
G
S
I
L
A
V
H
A
E
S
N
E
M
---
V
---
N
A
L
T
T
I
A
---
I
E
E
Q
R
L
T
V
K
D
Y
-----
S
E
A
R
P
I
V
S
E
L
E
A
V
E
R
I
L
------
R
F
A
Q
L
------
T
C
C
P
I
H
I
C
H
V
S
S
R
K
V
L
K
R
I
K
Q
A
K
G
E
G
V
N
V
S
V
E
T
C
P
H
Y
L
L
--
F
S
L
D
E
F
A
E
I
G
---
Y
L
A
K
----
C
A
----
P
P
L
R
E
R
Q
E
V
E
D
L
W
D
G
L
M
A
G
E
I
D
L
I
S
S
D
H
S
P
S
----
L
P
Q
M
K
T
-
G
K--
T
I
---
F
E
V
W
G
G
I
A
G
C
Q
N
T
L
A
V
M
L
T
E
G
Y
H
K
R
K
M
P
L
T
Q
I
V
Q
L
L
S
T
E
P
A
K
R
F
G
L
--
Y
PQ
K
G
T
I
Q
V
G
A
E
A
S
F
T
L
I
D
L
N
E
S
Y
T
L
N
A
S
D
L
Y
Y
R
H
P
I
S
P
Y
V
G
Q
R
F
R
G
K
V
K
H
T
I
C
Q
G
K
H
V
Y
Q
D
H
----------------------------------------
11
PsiBlast_PDB
74.06
25%
-65
- C2 -
1YNY
2
?
A:
[5-443]
----
I
R
G
G
T
V
V
T
A
A
D
-
T
Y
Q
A
--
D
V
L
I
E
G
E
R
V
V
A
I
G
H
--
Q
------
G
A
E
E
---
I
-
D
A
T
G
C
Y
V
I
P
G
G
I
D
P
H
T
H
L
D
M
P
FG
G
T
V
T
A
D
D
F
F
T
G
T
R
A
A
A
F
G
G
T
T
S
I
V
D
F
C
-
L
T
K
K
-
G
E
S
L
K
-
S
A
I
A
T
W
H
E
K
A
R
G
K
A
V
I
D
Y
G
F
H
L
M
I
AEAN
D
Q
V
--
L
E
E
L
E
S
V
I
-------------
S
S
E
G
I
T
S
L
K
V
F
M
A
Y
K
N
--
V
F
Q
A
--------
D
---
D
E
-----------------
T
L
F
K
T
L
V
K
A
K
E
L
G
A
L
V
Q
V
H
A
E
N
G
D
V
L
D
Y
L
---
T
---
K
K
A
---
L
A
E
G
N
T
D
P
I
Y
H
-----
A
Y
T
R
P
P
E
A
E
G
E
A
T
G
R
A
I
------
A
L
T
A
L
------
A
G
S
Q
L
Y
V
V
H
V
S
C
A
S
A
V
Q
R
I
A
E
A
R
E
K
G
W
N
V
Y
G
E
T
C
P
Q
Y
L
A
--
L
D
V
S
I
M
D
Q
P
D
FEG
A
K
Y
V
----
W
S
----
P
P
L
R
E
K
W
N
Q
E
V
L
W
S
A
L
K
N
G
I
L
Q
T
V
G
S
D
H
C
P
F
N
FRG
Q
K
E
L
G
R
-
G
---
D
F
---
T
K
I
P
N
G
G
P
L
I
E
D
R
L
T
I
L
Y
S
E
G
V
R
Q
G
R
I
S
L
N
Q
F
V
D
I
S
S
T
K
A
A
K
L
F
G
M
FP
R
--
K
G
T
I
A
V
G
S
D
A
D
I
V
I
F
D
P
H
V
K
R
T
L
S
V
E
T
H
H
M
N
V
D
Y
N
P
F
E
G
M
E
V
Y
G
E
V
V
S
V
L
S
R
G
S
F
V
V
R
D
K
Q
F
--------------------------------------
8
PsiBlast_PDB
73.71
28%
-68
- C2 -
3HM7
1
ALLB_BACHD
A:
[25-440]
----------------------
D
V
A
I
R
N
G
I
V
S
A
I
T
E
P
G
S
I
S
S
--
D
D
G
P
A
---
I
-
D
G
T
G
L
H
L
F
P
G
M
V
D
V
H
V
H
F
N
E
P
--
G
R
T
E
W
E
G
F
A
S
G
S
K
S
L
A
A
G
G
V
T
T
Y
F
D
M
P
L
N
S
N
P
-
P
T
I
T
R
-
E
E
L
D
K
K
R
Q
L
A
N
E
K
S
L
V
-------------
D
Y
--
R
-
F
W
G
G
L
V
-------------
P
G
-
N
I
D
H
L
Q
D
---
L
H
D
G
G
V
I
G
F
K
A
F
MSECG
T
---
D
D
----------
F
Q
F
S
H
D
E
T
L
L
K
G
M
K
K
I
A
A
L
G
S
I
L
A
V
H
A
E
S
N
E
M
---
V
---
N
---
A
L
T
T
I
A
I
E
E
Q
R
L
T
V
K
D
Y
-----
S
E
A
R
P
I
V
S
E
L
E
A
V
E
R
I
L
------
R
F
A
Q
L
------
T
C
C
P
I
H
I
C
H
V
S
S
R
K
V
L
K
R
I
K
Q
A
K
G
E
G
V
N
V
S
V
E
T
C
P
H
Y
L
L
FS
L
D
E
F
A
E
I
G
Y
L
---
A
--
K
----
C
A
----
P
P
L
R
E
R
Q
E
V
E
D
L
W
D
G
L
M
A
G
E
I
D
L
I
S
S
D
H
S
P
S
----
L
P
Q
M
K
T
G
K
---
T
I
---
F
E
V
W
G
G
I
A
G
C
Q
N
T
L
A
V
M
L
T
E
G
Y
H
K
R
K
M
P
L
T
Q
I
V
Q
L
L
S
T
E
P
A
K
R
F
G
L
YP
Q
--
K
G
T
I
Q
V
G
A
E
A
S
F
T
L
I
D
L
N
E
S
Y
T
L
N
A
S
D
L
Y
Y
R
H
P
I
S
P
Y
V
G
Q
R
F
R
G
K
V
K
H
T
I
C
Q
G
K
H
V
Y
Q
D
H
----------------------------------------
9
PsiBlast_PDB
73.67
27%
-67
- C2 -
4TQT
8
?
A:
[17-452]
---
V
I
K
G
G
T
V
I
T
A
D
R
-
T
F
R
A
--
D
I
L
I
E
D
G
K
I
A
A
I
G
D
--
S
L
E
----
G
D
E
V
---
I
-
D
A
S
G
C
Y
V
M
P
G
G
I
D
P
H
T
H
L
Q
M
P
FM
G
T
Y
S
S
D
D
F
D
T
G
T
A
A
A
L
A
G
G
T
T
M
V
V
D
F
V
------
L
P
D
S
E
G
N
L
L
D
A
L
Q
E
W
F
Q
K
A
G
K
A
-------------
R
T
D
Y
S
-
F
H
M
A
I
T
GWN
E
R
T
F
N
E
M
A
E
V
V
K
R
G
I
N
T
F
-
H
F
M
A
Y
K
--
G
A
L
M
V
--------
N
---
D
D
-----------------
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
M
P
L
V
H
A
E
N
G
D
I
---
V
A
Q
L
Q
---
A
K
L
---
M
A
E
G
N
D
G
P
E
A
H
-----
A
Y
S
R
P
P
E
V
E
G
E
A
T
N
R
A
I
------
M
I
A
D
Q
------
A
G
V
P
L
Y
V
V
H
V
S
C
E
Q
S
H
E
A
I
R
R
A
R
Q
K
G
M
R
V
F
G
E
P
L
I
Q
H
L
T
--
L
D
E
S
E
Y
H
N
R
D
---
W
D
Y
A
A
R
R
V
M
S
----
P
P
F
R
D
K
L
N
Q
D
S
L
W
A
G
L
A
A
G
S
L
Q
C
V
A
T
D
H
C
A
F
----
T
T
E
Q
K
R
-
Y
---
G
I
GNF
T
K
I
P
N
G
T
G
G
L
E
E
R
M
P
V
L
W
T
R
G
V
R
T
G
R
L
T
P
N
E
F
V
A
V
T
S
T
N
I
A
K
I
L
N
I
YP
Q
--
K
G
A
V
V
P
G
A
D
A
D
L
V
I
W
D
P
E
T
T
K
K
I
S
A
K
T
Q
H
S
S
I
D
Y
N
V
F
E
G
F
E
L
K
G
L
P
I
M
T
L
S
R
G
R
I
A
F
D
K
G
Q
V
--------------------------------------
12
PsiBlast_PDB
72.25
25%
-66
- C2 -
4KQN
2
?
A:
[4-442]
----
I
R
G
G
T
V
V
T
A
A
D
-
T
Y
Q
A
--
D
V
L
I
E
G
E
R
V
V
A
I
G
H
--
Q
L
A
A
--
A
G
A
E
E
---
I
-
D
A
T
G
C
Y
V
I
P
G
G
I
D
P
H
T
H
L
D
M
P
FG
G
T
V
T
A
D
D
F
F
T
G
T
R
A
A
A
F
G
G
T
T
S
I
V
D
F
C
-
L
T
K
K
-
G
E
S
L
K
-
S
A
I
A
T
W
H
E
K
A
R
G
K
A
V
I
D
Y
G
F
H
L
M
I
AEAN
D
Q
V
--
L
E
E
L
E
S
V
I
-------------
S
S
E
G
I
T
S
L
K
V
F
M
A
Y
K
N
--
V
F
Q
A
--------
D
---
D
E
-----------------
T
L
F
K
T
L
V
K
A
K
E
L
G
A
L
V
Q
V
H
A
E
N
G
D
V
L
D
Y
L
---
T
---
K
K
A
---
L
A
E
G
N
T
D
P
I
Y
H
-----
A
Y
T
R
P
P
E
A
E
G
E
A
T
G
R
A
I
------
A
L
T
A
L
------
A
G
S
Q
L
Y
V
V
H
V
S
C
A
S
A
V
Q
R
I
A
E
A
R
E
K
G
W
N
V
Y
G
E
T
C
P
Q
Y
L
A
--
L
D
V
S
I
M
D
Q
P
D
FEG
A
K
Y
V
----
W
S
----
P
P
L
R
E
K
W
N
Q
E
V
L
W
S
A
L
K
N
G
I
L
Q
T
V
G
S
D
H
C
P
F
N
FRG
Q
K
E
L
G
R
-
G
---
D
F
---
T
K
I
P
N
G
G
P
L
I
E
D
R
L
T
I
L
Y
S
E
G
V
R
Q
G
R
I
S
L
N
Q
F
V
D
I
S
S
T
K
A
A
K
L
F
G
M
FP
R
--
K
G
T
I
A
V
G
S
D
A
D
I
V
I
F
D
P
H
V
K
R
T
L
S
V
E
T
H
H
M
N
V
D
Y
N
P
F
E
G
M
E
V
Y
G
E
V
V
S
V
L
S
R
G
S
F
V
V
R
D
K
Q
F
--------------------------------------
10
PsiBlast_PDB
72.08
25%
-65
- C2 -
4KIR
2
?
A:
[4-442]
----
I
R
G
G
T
V
V
T
A
A
D
-
T
Y
Q
A
--
D
V
L
I
E
G
E
R
V
V
A
I
G
H
--
Q
L
S
V
--
N
G
A
E
E
---
I
-
D
A
T
G
C
Y
V
I
P
G
G
I
D
P
H
T
H
L
D
M
P
FG
G
T
V
T
A
D
D
F
F
T
G
T
R
A
A
A
F
G
G
T
T
S
I
V
D
F
C
-
L
T
K
K
-
G
E
S
L
K
-
S
A
I
A
T
W
H
E
K
A
R
G
K
A
V
I
D
Y
G
F
H
L
M
I
AEAN
D
Q
V
--
L
E
E
L
E
S
V
I
-------------
S
S
E
G
I
T
S
L
K
V
F
M
A
Y
K
N
--
V
F
Q
A
--------
D
---
D
E
-----------------
T
L
F
K
T
L
V
K
A
K
E
L
G
A
L
V
Q
V
H
A
E
N
G
D
V
L
D
Y
L
---
T
---
K
K
A
---
L
A
E
G
N
T
D
P
I
Y
H
-----
A
Y
T
R
P
P
E
A
E
G
E
A
T
G
R
A
I
------
A
L
T
A
L
------
A
G
S
Q
L
Y
V
V
H
V
S
C
A
S
A
V
Q
R
I
A
E
A
R
E
K
G
W
N
V
Y
G
E
T
C
P
Q
Y
L
A
--
L
D
V
S
I
M
D
Q
P
D
F
E
G
A
K
Y
V
----
W
S
----
P
P
L
R
E
K
W
N
Q
E
V
L
W
S
A
L
K
N
G
I
L
Q
T
V
G
S
D
H
C
P
F
N
FRG
Q
K
E
L
G
R
-
G
---
D
F
---
T
K
I
P
N
G
G
P
L
I
E
D
R
L
T
I
L
Y
S
E
G
V
R
Q
G
R
I
S
L
N
Q
F
V
D
I
S
S
T
K
A
A
K
L
F
G
M
FP
R
--
K
G
T
I
A
V
G
S
D
A
D
I
V
I
F
D
P
H
V
K
R
T
L
S
V
E
T
H
H
M
N
V
D
Y
N
P
F
E
G
M
E
V
Y
G
E
V
V
S
V
L
S
R
G
S
F
V
V
R
D
K
Q
F
--------------------------------------