@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1867: (2016-03-29 )
VRKFVYQFSEGSKEMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTANNKHLSEAIFDEVKIHLAELEKQTGKIFGFAENPLLVSVRSGAPFSMPGMMDTVLNLGLNDQAAEGLANLTGDARSAYDSYRRFIQMFGDVVFEIPSYHFEQALSRIKKANDYRLDTELTATDLSELIDAYKLIFSQATGTDFPQDPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASFGTAVNIQAMVFGNTGETSGTGITFTRNPSTGEKKVFGEFLLNAQGEDVVAGIRTPEPISALEERMPTVYKELLHTCELLENHYLDMQDIEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVQEGKITRQEAIMRVETKQLHQLLHPTFDESALKNGQVIATGLPASPGAATGQIFFAAKEAVQATERGIPVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCAELTINEKEKTIILPTGDTLHEGDALSLDGSSGKVYLGEIALREAQIGGHFDELMAWADTEKRLMIRVNADTPPDFKKALLFGAEGIGLCRTEHMFFDEKRIHYVRQMILAESLSERESVLTTLKEMQKADFSELFRIADGRAVNIRLLDPPLHEFLPKTKQEIEQLASAMNRTVPQITKRINELSEANPMLGHRGCRLAITFPEIYRMQTEAIIESAVTLHDEGIDVHPEIMIPLIATKSELSYIKKEMKHAIHTIFDRERVMLPYDIGTMIEIPRACVTADEIAEEAEFFSFGTNDLTQLTYGFSRDDATKFLADYYEKDILSKDPFVSIDKNGVGALVEMAVTRGRMTSEHLKMGVCGEHGGDPESIQFFHQLGLTYVSCSPYRVPIARLAAAQAALAEKHLIPTI
Atome Classification :
(21 SA)
---........----.10---.----........20........30........40........50........60........70........80........90........100.......110.......120.-..-....130.......140.......150.......160.......170.......180.......-190-........200.......210.......220.......230.......240.......250.......260.......270.......280.......290----------------------.-----------------------.......300.......310.......320.......330.......340.......350.......360.......370.......380..--.--....390.......400.......410.......420.......430.......440-........450.......460.......470.......480.......490.......500......--.510.......520.......530...-----------------------....540.......550.......560.....-..-570.......580.......590.......600.......610.......620.......630--.--......640.......650.......660.......670.......680.......690-..-.....700.......710-------.......720....-...730........740.......750.......760.......770......-.780.......790.......800..-......810.......820---........830.......840.......850.......860.......870.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---VR
K
F
V
Y
QF----SE----
G
----
S
K
E
M
K
N
LLGGKGA
N
L
A
E
MTNIGLPVPP
G
F
I
I
S
TDACNDYTAN
N
K
H
L
S
E
A
I
F
D
E
V
K
I
H
L
A
E
L
E
K
QT
G
K
I
F
GFAEN
P
L
L
V
S
VRSGAPFSMP
G
M
M
D
T
V
L
NLGL
N
D
Q
A
A
E
G
L
A
N
LT-G
D
-
A
R
S
A
Y
D
S
Y
R
R
F
I
Q
M
F
G
D
V
V
F
EI
P
S
Y
H
F
E
Q
A
L
S
R
I
K
KANDYRLDTEL
T
A
T
D
L
S
E
L
I
D
A
Y
K
L
I
F
SQ-A-T-GTDFPQ
D
P
L
E
Q
L
R
L
A
I
I
A
V
F
D
SWMN
P
R
A
V
I
Y
R
R
L
H
DIDASFG
T
A
V
N
I
Q
A
M
V
FGNTGETSG
T
G
I
T
F
TRNPSTG
E
K
K
V
F
G
E
F
L
LNAQGE
D
V
V
AGIRTPE
P
I
S
-----------------------
A
-----------------------
L
E
E
R
M
P
T
V
Y
K
E
L
L
H
T
C
E
L
L
E
N
HYLD
M
Q
D
I
E
F
T
I
EK
G
K
L
Y
V
L
QTRSGK
R
T
A
K
A
A
I
Q
T
A
V
D
F
V
Q
EGK
I
T
R
Q
E
A
I
M
R
V
E
T
K
Q
L
H
Q
L
LHPTF
D
E
S
A
--L--KNG
Q
V
I
A
TGLPASPGAAT
G
Q
I
F
F
A
A
K
E
A
V
Q
A
T
ERG
I
P
V
I
L
V
RNET
S
P
E
D
I
E
G
M
ARS--
N
A
I
L
T
AHGGM
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
I
AGC
A
E
L
T
INEKE
K
T
I
I
LPTGDTLHEGD
A
L
S
LDGSSG
K
V
Y
L
G
--
E
I
A
L
R
E
A
QIGG
H
F
D
E
L
M
A
W
ADTE
K
R
L
M
-----------------------
I
R
V
NADT
P
P
D
F
K
K
A
L
L
FGAEGIGLCR
T
E
H
M
F
F
-
D
E
-
K
R
I
H
Y
V
R
Q
M
I
L
A
E
S
L
S
E
R
E
S
V
L
T
T
L
K
E
M
Q
K
A
D
F
S
E
L
F
R
IADG
R
A
V
N
I
R
LLDP
P
L
H
E
F
L
P
K
T
K
Q
--
E
--
I
E
Q
L
A
S
A
M
N
R
T
V
P
Q
I
T
K
R
I
N
E
L
SEANPMLGHRG
C
R
L
A
IT
F
P
E
I
Y
R
M
Q
T
E
A
I
I
E
S
A
V
T
LH-DE-GIDVHP
E
I
M
I
P
L
IAT
K
S
E
-------
L
S
Y
I
K
K
E
M
K
H
A
I
H
T
-
I
FDRE-
R
V
M
LPYDI
G
T
M
I
EI
P
R
A
CV
T
A
D
E
I
A
E
E
A
E
F
F
SFGTN
D
L
T
Q
L
TYGFS
R
-
D
D
A
T
K
F
L
A
D
Y
Y
E
K
D
ILSKDP
F
V
S
-ID-KN
G
V
G
A
L
V
E
M
A
V
TRGRM
T
----
S
E
H
LKMGVCGEHGG
D
P
E
S
I
Q
F
F
H
Q
LG
L
T
Y
VSCSPY
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
A
EKHLIPTI
44
Fugue
97.85
58%
-87
- C2 -
1KBL
6
PPDK_CLOSY
A:
[1-872]
AKW
V
Y
K
----
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
-N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
-
M
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q----------------------------------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
-
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
D
I
E
T
Q
E
A
-
S
V
S
-
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-------
1
PsiBlast_PDB
97.03
57%
-88
- C2 -
1KBL
6
PPDK_CLOSY
A:
[2-860]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
--
D
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
2
PsiBlast_PDB
96.14
57%
-87
- C2 -
1KC7
6
PPDK_CLOSY
A:
[2-860]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
--
D
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
43
Fugue
95.42
58%
-83
- C2 -
1JDE
2
PPDK_CLOSY
A:
[1-873]
----
A
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
A
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
-
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
E
T
Q
--
E
-----
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
------
4
PsiBlast_PDB
95.17
57%
-85
- C2 -
1DIK
3
PPDK_CLOSY
A:
[3-861]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
A
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
------
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
6
PsiBlast_PDB
95.10
57%
-94
- C2 -
2R82
2
PPDK_CLOSY
A:
[3-861]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
E
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
D
T
G
E
K
G
I
Y
G
R
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
--
D
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
3
PsiBlast_PDB
94.93
57%
-83
- C2 -
1GGO
2
PPDK_CLOSY
A:
[2-860]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
A
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
------
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
5
PsiBlast_PDB
94.55
57%
-82
- C2 -
2DIK
2
PPDK_CLOSY
A:
[2-860]
-----
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
A
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
A
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
-
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
------
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
-------------------
8
PsiBlast_PDB
93.73
53%
-91
- C2 -
1VBG
4
PPDK1_MAIZE
A:
[3-873]
----
K
K
R
V
F
H
F
G
KGK
S
E
----
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
C
A
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
-
G
E
--
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
-
A
-
K
-
G
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
D
-----------------------
A
-----------------------
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
E
N
P
S
--
A
--
Y
K
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
E
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
--
V
G
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
D
A
E
K
L
V
T
I
-
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
I
L
G
--
K
Q
P
L
S
P
P
A
L
S
G
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
-----------------------
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
D
-
E
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
--
E
D
I
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
-
N
Q
-
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
P
Q
E
-------
L
G
H
Q
V
T
L
I
R
Q
V
A
E
K
-
V
F
A
N
V
-
G
K
T
I
G
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
-
L
D
-
Q
R
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
------------
9
PsiBlast_PDB
93.20
53%
-92
- C2 -
1VBH
3
PPDK1_MAIZE
A:
[3-873]
----
K
K
R
V
F
H
F
G
KGK
S
E
----
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
C
A
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
-
G
E
--
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
-
A
-
K
-
G
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
---------
R
T
P
E
D
L
D
-----------------------
A
-----------------------
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
E
N
P
S
--
A
--
Y
K
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
E
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
--
V
G
I
L
T
E
---
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
D
A
E
K
L
V
T
I
-
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
I
L
G
--
K
Q
P
L
S
P
P
A
L
S
G
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
-----------------------
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
D
-
E
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
--
E
D
I
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
-
N
Q
-
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
P
Q
E
-------
L
G
H
Q
V
T
L
I
R
Q
V
A
E
K
-
V
F
A
N
V
-
G
K
T
I
G
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
-
L
D
-
Q
R
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
------------
7
PsiBlast_PDB
90.15
51%
-84
- C2 -
2X0S
-
?
A:
[3-899]
----
K
K
W
V
Y
Y
F
GGGN
A
D
----
G
----
N
K
N
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
V
N
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
-
E
T
E
T
I
P
Q
E
V
A
D
Q
V
R
E
N
V
S
R
V
E
K
E
M
G
A
K
F
G
D
P
A
N
P
L
L
F
S
V
R
S
G
A
A
A
S
M
----
D
T
V
L
N
L
G
L
N
K
V
T
V
D
A
W
V
R
R
A
-
P
R
L
E
R
F
V
Y
D
S
Y
R
R
F
I
T
M
Y
A
D
I
V
M
Q
V
G
R
E
D
F
E
E
A
L
S
R
M
K
E
R
R
G
T
K
F
D
T
D
L
T
A
S
D
L
K
E
L
C
D
G
Y
L
E
L
F
E
L
-
K
-
T
-
G
C
S
F
P
Q
D
P
V
M
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
L
L
G
T
A
V
N
V
Q
A
M
V
F
G
N
I
N
D
R
S
A
T
G
V
A
F
S
R
S
P
S
T
G
E
N
F
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
N
H
S
L
S
L
R
W
A
K
A
H
GVG
E
E
E
R
R
K
RYP
S
-----------------------
M
E
E
A
M
P
E
N
Y
R
L
L
C
D
V
R
K
R
L
E
N
H
Y
R
D
M
Q
D
L
E
F
T
V
Q
D
G
R
L
W
L
L
Q
C
R
N
G
K
R
T
I
H
A
A
V
R
I
A
I
D
M
V
N
E
G
L
I
S
R
E
E
A
V
L
R
I
D
P
Y
Q
V
D
H
L
M
H
P
N
L
E
P
G
A
--
E
--
K
A
N
K
P
I
G
R
G
L
A
A
S
P
G
A
A
V
G
Q
V
V
F
D
A
E
S
A
K
E
W
S
G
R
G
K
K
V
I
M
V
R
L
E
T
S
P
E
D
L
A
G
M
D
A
A
--
C
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
D
M
V
I
R
G
K
S
F
K
L
---
N
G
S
V
F
R
E
G
D
Y
I
T
I
D
G
S
K
G
L
I
Y
A
G
--
K
L
K
L
R
S
P
D
L
K
G
S
F
Q
T
I
L
Q
W
C
Q
E
M
K
R
L
G
-----------------------
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
H
M
F
F
-
E
G
-
S
R
I
N
F
I
R
E
M
I
L
A
D
S
A
S
G
R
K
A
A
L
D
K
L
L
P
I
Q
R
A
D
F
V
G
I
L
R
A
M
R
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
V
P
H
D
A
A
--
A
--
Q
F
E
L
A
Q
K
L
G
M
P
A
E
K
V
R
N
R
V
N
A
L
H
E
L
N
P
M
L
G
H
R
G
C
R
L
G
I
T
Y
P
E
I
Y
N
M
Q
V
R
A
I
I
E
A
A
I
A
V
S
-
E
E
-
G
S
S
V
I
P
E
I
M
V
P
L
V
G
K
K
E
E
-------
L
S
L
I
R
E
E
V
V
K
T
A
E
A
-
V
I
T
K
S
-
G
K
R
V
H
Y
T
V
G
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
-
D
D
A
G
P
F
L
R
H
Y
G
N
L
G
I
Y
A
Q
D
P
F
Q
S
-
I
D
-
Q
E
G
I
G
E
L
V
R
I
A
V
T
K
G
R
R
V
----
K
P
M
L
K
M
G
I
C
G
E
H
G
G
D
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
D
R
R
-----
21
HHSearch
89.00
50%
-72
- C2 -
1KBL
6
PPDK_CLOSY
A:
[1-872]
----
A
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
M
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
P
T
F
N
P
A
A
L
K
A
--
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
--
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
D
I
E
--
T
Q
E
A
S
V
S
G
---
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
-
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
D
Q
-
T
-
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-------
23
HHSearch
85.19
46%
-77
* C2 *
1VBG
4
PPDK1_MAIZE
A:
[3-875]
----
K
K
R
V
F
H
F
----
G
K
GKSE
G
----
N
K
T
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
A
S
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
C
A
L
P
A
G
L
W
A
E
I
V
D
G
L
Q
W
V
E
E
Y
M
G
A
T
L
G
D
P
Q
R
P
L
L
L
S
V
R
S
G
A
A
V
S
M
P
G
M
M
D
T
V
L
N
L
G
L
N
D
E
V
A
A
G
L
A
A
K
S
--
G
-
E
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
V
M
D
I
P
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
L
K
N
D
T
D
L
T
A
S
D
L
K
E
L
V
G
Q
Y
K
E
V
Y
L
S
-
A
-
K
-
G
E
P
F
P
S
D
P
K
K
Q
L
E
L
A
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
G
N
M
G
N
T
S
G
T
G
V
L
F
T
R
N
P
N
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
D
-----------------------
A
-----------------------
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
A
V
K
I
A
V
D
M
V
N
E
G
L
V
E
P
R
S
A
I
K
M
V
E
P
G
H
L
D
Q
L
L
H
P
Q
F
E
N
P
S
--
A
YK
D
Q
V
I
A
T
G
L
P
A
S
P
G
A
A
V
G
Q
V
V
F
T
A
E
D
A
E
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
G
--
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
D
A
E
K
L
V
T
I
G
G
H
V
L
R
E
G
E
W
L
S
L
N
G
S
T
G
E
V
I
L
G
K
Q
P
--
L
S
P
P
A
L
S
---
G
D
L
G
T
F
M
A
W
V
D
D
V
R
K
L
K
-----------------------
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
-
A
S
D
E
R
I
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
E
D
I
--
V
S
E
L
C
A
E
T
G
A
N
Q
E
D
A
L
A
R
I
E
K
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
S
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
A
A
I
A
M
T
-
N
Q
-
G
V
Q
V
F
P
E
I
M
V
P
L
V
G
T
P
Q
E
-------
L
G
H
Q
V
T
L
I
R
Q
V
A
E
K
-
V
F
A
N
V
-
G
K
T
I
G
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
-
D
D
V
G
K
F
I
P
V
Y
L
A
Q
G
I
L
Q
H
D
P
F
E
V
-
L
D
Q
R
-
G
V
G
E
L
V
K
F
A
T
E
R
G
R
K
A
----
R
P
N
L
K
V
G
I
C
G
E
H
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
L
----------
22
HHSearch
82.00
45%
-71
- C2 -
2X0S
-
?
A:
[3-900]
----
K
K
W
V
Y
Y
F
----
G
G
----
G
NADG
N
K
N
M
K
E
L
L
G
G
K
G
A
N
L
A
E
M
V
N
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
E
T
E
-
T
I
P
Q
E
V
A
D
Q
V
R
E
N
V
S
R
V
E
K
E
M
G
A
K
F
G
D
P
A
N
P
L
L
F
S
V
R
S
G
A
A
A
S
M
----
D
T
V
L
N
L
G
L
N
K
V
T
V
D
A
W
V
R
R
A
P
R
L
-
E
R
F
V
Y
D
S
Y
R
R
F
I
T
M
Y
A
D
I
V
M
Q
V
G
R
E
D
F
E
E
A
L
S
R
M
K
E
R
R
G
T
K
F
D
T
D
L
T
A
S
D
L
K
E
L
C
D
G
Y
L
E
L
F
E
L
-
K
-
T
-
G
C
S
F
P
Q
D
P
V
M
Q
L
F
A
A
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
L
L
G
T
A
V
N
V
Q
A
M
V
F
G
N
I
N
D
R
S
A
T
G
V
A
F
S
R
S
P
S
T
G
E
N
F
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
N
-----------------------
H
S
L
S
L
R
W
A
K
A
H
GVG
E
E
E
R
R
K
RYPS
M
E
E
A
M
P
E
N
Y
R
L
L
C
D
V
R
K
R
L
E
N
H
Y
R
D
M
Q
D
L
E
F
T
V
Q
D
G
R
L
W
L
L
Q
C
R
N
G
K
R
T
I
H
A
A
V
R
I
A
I
D
M
V
N
E
G
L
I
S
R
E
E
A
V
L
R
I
D
P
Y
Q
V
D
H
L
M
H
P
N
L
E
P
G
A
EK
A
--
N
K
P
I
G
R
G
L
A
A
S
P
G
A
A
V
G
Q
V
V
F
D
A
E
S
A
K
E
W
S
G
R
G
K
K
V
I
M
V
R
L
E
T
S
P
E
D
L
A
G
M
D
A
A
C
G
--
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
D
M
V
I
--
R
G
K
S
F
K
L
N
G
S
V
F
R
E
G
D
Y
I
T
I
D
G
S
K
G
L
I
Y
A
G
K
L
K
--
L
R
S
P
D
L
---
K
G
S
F
Q
T
I
L
Q
W
C
Q
E
M
K
R
L
G
-----------------------
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
H
M
F
F
-
E
G
-
S
R
I
N
F
I
R
E
M
I
L
A
D
S
A
S
G
R
K
A
A
L
D
K
L
L
P
I
Q
R
A
D
F
V
G
I
L
R
A
M
R
G
L
P
V
T
I
R
L
L
D
P
P
L
H
E
F
V
P
H
D
A
A
--
A
--
Q
F
E
L
A
Q
K
L
G
M
P
A
E
K
V
R
N
R
V
N
A
L
H
E
L
N
P
M
L
G
H
R
G
C
R
L
G
I
T
Y
P
E
I
Y
N
M
Q
V
R
A
I
I
E
A
A
I
A
V
S
-
E
E
-
G
S
S
V
I
P
E
I
M
V
P
L
V
G
K
K
E
E
-------
L
S
L
I
R
E
E
V
V
K
T
A
E
A
V
I
T
K
S
--
G
K
R
V
H
Y
T
V
G
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
-
D
D
A
G
P
F
L
R
H
Y
G
N
L
G
I
Y
A
Q
D
P
F
----
Q
-
S
-
I
D
Q
E
G
I
G
E
L
V
R
I
A
V
T
K
G
R
R
V
K
P
M
L
K
M
G
I
C
G
E
H
G
G
D
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
D
R
R
A
----
46
Fugue
62.33
55%
-90
- C2 -
1DIK
2
?
?:
[510-874]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
-
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
------
45
Fugue
61.50
55%
-87
- C2 -
1KBL
5
PPDK_CLOSY
A:
[509-872]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
E
T
Q
E
A
-
S
V
S
-
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
L
K
-----------------------
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
-
E
A
-
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
F
V
P
H
T
E
E
--
E
--
Q
A
E
L
A
K
N
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
-
E
E
T
G
I
D
I
V
P
E
I
M
I
P
L
V
G
E
K
K
E
-------
L
K
F
V
K
D
V
V
V
E
V
A
E
Q
-
V
K
K
E
K
-
G
S
D
M
Q
Y
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
-
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
-
L
D
-
Q
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
----
R
P
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-------
48
Fugue
61.28
58%
-63
- C2 -
1KBL
1
PPDK_CLOSY
A:
[1-375]
AKW
V
Y
K
-
F
E
-------
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
-N
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
-
A
-
M
N
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q----------------------------------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
59.98
58%
-60
- C2 -
1DIK
1
?
?:
[2-380]
----
A
K
W
V
Y
K
F
----
E
E
----
G
----
N
A
S
M
R
N
L
L
G
G
K
G
C
N
L
A
E
M
T
I
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
G
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
G
K
K
F
G
D
T
E
D
P
L
L
V
S
V
R
S
A
A
R
A
S
M
P
G
M
M
D
T
I
L
N
L
G
L
N
D
V
A
V
E
G
F
A
K
K
T
-
G
N
-
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
V
M
E
V
P
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
Y
K
E
A
M
-
N
-
G
E
E
F
P
Q
E
P
K
D
Q
L
M
G
A
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
G
T
A
V
N
V
Q
T
M
V
F
G
N
K
G
E
T
S
G
T
G
V
A
F
T
R
N
P
S
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
-----------------------
Q
-----------------------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
V
V
R
I
E
A
K
S
L
D
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.92
25%
-83
- C2 -
2WQD
1
PT1_STAAU
A:
[158-536]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
N
D
L
T
P
S
D
T
A
Q
L
N
K
E
FV
Q
G
F
A
T
N
I
G
G
R
T
S
A
S
A
I
M
S
R
S
L
E
I
P
A
I
V
G
T
K
S
I
T
-------------
Q
E
V
K
Q
G
D
M
I
I
V
D
G
L
N
G
D
V
I
V
N
--
P
T
E
----------
D
E
L
I
A
Y
Q
D
K
R
E
R
Y
F
A
D
K
K
E
L
Q
K
L
RD
A
D
T
V
T
VDG
V
H
A
E
L
A
A
N
I
G
T
P
N
D
L
P
G
V
I
E
N
G
A
Q
G
I
G
L
Y
R
T
E
F
L
Y
M
-
G
-------------------
R
D
Q
M
P
T
--
E
E
E
Q
F
E
A
Y
K
E
V
L
E
A
M
G
G
K
R
V
V
V
R
T
L
D
I
G
G
D
K
E
L
---------------
S
Y
L
N
--
L
P
E
---------
E
M
N
P
F
L
G
Y
R
A
I
R
L
S
L
A
Q
Q
D
I
F
R
P
Q
L
R
A
L
L
R
A
S
V
Y
---------
G
K
L
N
I
M
F
P
M
V
A
T
I
N
E
F
R
E
A
K
A
I
L
L
E
E
K
E
N
L
K
N
E
G
H
D
-
I
S
D
-------
D
I
E
L
G
I
M
V
E
I
P
A
T
A
A
L
A
D
V
F
A
K
E
V
D
F
F
S
I
G
T
N
D
L
I
Q
Y
T
L
A
A
D
R
M
S
E
R
V
S
Y
L
Y
Q
P
Y
N
P
S
I
L
R
L
------------
V
K
Q
V
I
E
A
S
H
K
E
G
K
W
T
----------
G
M
C
G
E
M
A
G
D
E
T
A
I
P
L
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
L
K
A
R
-----------------
50
Fugue
48.11
60%
-52
- C2 -
1KBL
-
PPDK_CLOSY
A:
[376-508]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
P
T
F
N
P
A
A
--
L
--
K
A
G
E
V
I
G
S
A
L
P
A
S
P
G
A
A
A
G
K
V
Y
F
T
A
D
E
A
K
A
A
H
E
K
G
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
--
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
I
-
K
I
N
E
E
A
K
T
F
E
L
G
G
H
T
F
A
E
G
D
Y
I
S
L
D
G
S
T
G
K
I
Y
K
G
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
46.77
32%
-69
- C2 -
2XZ9
2
?
A:
[13-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
P
D
G
K
K
-
V
M
-----------------------
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
F
L
Y
M
-
D
R
-
N
S
L
P
---------
S
E
E
-----------
E
Q
F
E
A
Y
K
E
V
V
E
K
M
G
G
R
P
V
T
I
R
T
L
D
I
G
G
D
K
E
L
P
Y
L
--------------------------
D
M
P
K
E
M
N
P
F
L
G
Y
R
A
I
R
L
C
L
D
R
P
D
I
F
K
T
Q
L
R
A
I
L
R
A
S
A
-----
Y
-
G
---
N
V
Q
I
M
Y
P
M
I
S
S
V
E
E
-------
V
R
K
A
N
S
I
L
E
E
V
K
A
E
-
L
D
R
E
G
V
K
Y
D
K
E
I
K
V
G
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
-
M
N
E
--
H
V
K
E
Y
----------
Y
Q
P
-
F
H
-
P
-
A
I
L
R
L
V
K
M
V
I
D
A
A
H
K
E
------
G
K
F
A
A
M
C
G
E
M
A
G
D
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
K
A
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