@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2472: (2016-04-04 )
MSFASETKKELTHMDVSDSDAKVELAAFIRMNGAISFSSQLVIMDVQTENAAIARRMYQLLKDLYEVPIELLVRRKMKLKKNNVYIVRLKSGTRGILEDLRILEPPMTFTKSIDRGFVKKRSAKRAYLRGAFLASGSVNNPETSSYHLEIFSVYEEHNEAICALMNQFDLNARTLERKNGFITYLKEAEKITEFLSIIGATSALLHFEDVRIMRDMRNSVNRLVNCETANLNKTINAAVRQIDNIKYIQSTVGLEALPERLREIAALRIANEDVTLKELGEMLTTGQVSKSGINHRLRKLDQIAERLRSGETPAQVGLKISNS
Atome Classification :
(20 SA)
------.........10.....-...20..-......30.......-----.-----40----.--------.----.--......50--.......----.----60.-----...----------------------.---...70........80.-.......90..--......-100..-----..-...110..-....-.120.......130....----...140.--.-------.--------....150.----.----.....160--..-----...-..170-.....--.-----------.180...---....190..---------...--..200.......210......--.220....----------...230....-----------..------.240.....----..250.......260-....-------...270.......---280.......290.....-----..300--........310...-...-..320.----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MS
F
A
S
E
T
K
K
E
LTHMDV-SDSDA
K
V
-
E
L
A
A
F
I
R
MN
G
A
I
SFS-----
S
-----
Q
-----
L
--------
V
----
I
--
M
D
VQTE
N
A
--
A
I
A
R
R
M
Y
----
Q
----
L
L
K
-----
D
L
Y
----------------------
E
---
V
P
I
E
L
L
V
R
R
K
M
KLKKN-
N
V
Y
I
V
R
LKSG
T
--
R
G
I
L
E
D
-
L
R
ILE-----PP-
M
T
F
T
K
S
I
D
-
R
G
F
V
-
K
K
R
SA
K
R
A
Y
L
R
G
A
F
LASG----SVNNPET--S-------
S
--------
Y
H
L
E
I
F
S
V
----
Y
----
E
E
H
N
E
A
I
C
--
A
L
-----
M
N
Q
-FDLN
A
-
R
T
L
ER--K-----------N
G
F
I
T
Y
L
---
K
E
A
E
K
I
T
E
F
---------
L
S
I
--
I
G
A
T
S
A
L
L
H
F
E
D
V
R
I
M
R
D
M
R
N
--
S
V
N
R
L
VNC----------ETANL
N
K
T
I
N
-----------
A
A
------
V
R
QID
N
I
K
Y
----
I
Q
S
TV
G
L
E
A
L
P
E
R
L
R
-
E
I
A
A
-------
L
RIANEDV
T
L
K
E
L
---
G
E
M
L
TTGQV
S
K
S
G
I
N
H
R
L
-----
R
K
L
D
---
Q
I
A
E
R
L
RSGE-T
P
A
-
Q
V
G
-
L
K
ISNS----------
1
PsiBlast_PDB
88.18
32%
-102
- C5 -
3HYI
3
?
A:
[8-291]
-------
T
F
S
E
E
I
K
E
E
L
V
N
V
P
F
-
G
S
R
E
E
V
I
S
E
L
L
G
F
I
K
A
R
G
D
L
D
V
K
-----
S
-----
R
-----
H
--------
I
----
V
--
F
S
L
H
S
--
F
--
A
A
S
R
R
L
L
----
N
----
L
M
K
-----
Y
L
S
----------------------
K
---
P
V
S
E
I
I
V
E
K
----
K
K
R
-
Y
I
K
I
------
T
--
A
E
Y
S
E
S
-
F
M
V
I
E
-----
P
---
F
F
D
V
A
L
----
F
V
--------
S
F
L
R
G
L
F
L
S
G
G
----
S
M
T
N
P
R
Y
--
H
----------------
Y
H
L
E
I
-
N
L
----
F
----
E
E
E
T
L
A
L
T
R
K
S
L
-----
K
D
F
-
F
N
I
N
A
-
G
I
I
E
L
--
R
-----------
N
T
R
K
L
Y
I
---
K
S
I
K
D
I
L
V
F
---------
L
E
A
--
I
G
V
Q
R
K
L
E
E
I
D
R
I
V
T
E
R
K
V
I
G
--
D
V
N
R
T
V
N
F
----------
I
E
A
N
A
I
R
T
A
N
-----------
S
T
------
A
R
Q
I
R
A
I
E
L
----
I
K
E
N
M
G
L
E
N
L
P
E
D
L
R
-
R
V
A
L
-------
V
R
L
R
N
K
E
L
S
L
R
E
L
---
G
K
K
L
---
N
L
T
K
S
Q
I
Y
S
K
L
-----
K
R
I
I
---
K
I
A
E
R
F
-----------------------------
15
HHSearch
84.51
32%
-80
- C5 -
3HYI
3
?
A:
[7-293]
------
R
T
F
S
E
E
I
K
E
E
L
V
N
V
P
F
G
S
R
E
E
V
I
S
-
E
L
L
G
F
I
K
A
R
G
D
L
D
V
K
-----
S
-----
R
-------------------
H
--
I
V
F
S
L
H
S
F
--
A
A
S
R
R
L
L
----
N
----
L
M
K
-----
Y
L
S
----------------------
K
---
P
V
S
E
I
I
V
E
K
----
K
-
K
-
R
Y
I
K
I
T
A
E
Y
S
---
E
S
F
M
---------------------
V
I
E
-
P
--
F
-
F
D
V
A
L
F
V
S
F
L
R
G
L
F
L
S
G
G
----
S
M
T
N
P
R
---
Y
-------
H
--------
Y
H
L
E
I
N
L
F
----
E
----
E
E
T
L
A
L
T
R
--
K
S
-----
L
K
D
F
F
N
I
N
A
-
G
I
I
E
L
--
R
-----------
N
T
R
K
L
Y
I
---
K
S
I
K
D
I
L
V
F
---------
L
E
A
--
I
G
V
Q
R
K
L
E
E
I
D
R
I
V
T
E
R
K
V
I
G
--
D
V
N
R
T
V
N
F
----------
I
E
A
N
A
I
R
T
A
N
-----------
S
T
------
A
R
Q
I
R
A
I
E
L
----
I
K
E
N
M
G
L
E
N
L
P
E
D
L
R
-
R
V
A
L
-------
V
R
L
R
N
K
E
L
S
L
R
E
L
---
G
K
K
L
-
N
--
L
T
K
S
Q
I
Y
S
K
L
-----
K
R
I
I
---
K
I
A
E
R
F
G
D
---------------------------
36
Fugue
81.10
31%
-59
- C5 -
3HYI
3
?
A:
[7-294]
------
R
T
F
S
E
E
I
K
E
E
L
V
N
V
P
F
G
S
R
E
E
V
I
S
-
E
L
L
G
F
I
K
A
R
G
D
L
D
V
K
-----
S
-----
R
-------------------
H
--
I
V
F
S
L
H
S
F
--
A
A
S
R
R
L
L
----
N
----
L
M
K
-----
Y
L
S
----------------------
K
---
P
V
S
E
I
I
V
E
K
K
K
R
Y
I
K
I
-
T
A
E
-------------------------------
Y
S
E
S
F
M
V
-
I
E
P
F
-
F
D
V
A
L
F
V
S
F
L
R
G
L
F
L
S
G
G
----
S
M
T
N
P
R
---
Y
-------
H
--------
Y
H
L
E
I
N
L
F
E---
E
----
E
T
L
A
L
T
R
K
--
S
L
-----
K
D
F
-
F
N
I
N
A
-
G
I
I
E
L
--
R
-----------
N
T
R
K
L
Y
I
---
K
S
I
K
D
I
L
V
F
---------
L
E
A
--
I
G
V
Q
R
K
L
E
E
I
D
R
I
V
T
E
R
K
V
I
G
--
D
V
N
R
T
V
N
F
----------
I
E
A
N
A
I
R
T
A
N
-----------
S
T
------
A
R
Q
I
R
A
I
E
L
----
I
K
E
N
M
G
L
E
N
L
P
E
D
L
R
-
R
V
A
L
-------
V
R
L
R
N
K
E
L
S
L
R
E
L
---
G
K
K
L
---
N
L
T
K
S
Q
I
Y
S
K
L
-----
K
R
I
I
---
K
I
A
E
R
F
G
D
V
--------------------------
2
PsiBlast_PDB
65.70
27%
-89
- C5 -
3HYJ
3
?
A:
[8-191]
-------
T
F
S
E
E
I
K
E
E
L
V
N
V
P
F
-
G
S
R
E
E
V
I
S
E
L
L
G
F
I
K
A
R
G
D
L
D
-------------
R
-----
H
--------
I
----
V
--
F
S
L
H
S
--
F
--
A
A
S
R
R
L
L
----
N
----
L
M
K
-----
Y
L
S
----------------------
K
---
P
V
S
E
I
I
V
E
K
S
H
----
R
-
Y
I
K
I
------
T
--
A
E
Y
S
E
S
-
F
M
V
I
E
-----
P
F
-
F
D
V
A
L
F
V
--------------
S
F
L
R
G
L
F
L
S
G
G
----
S
M
T
N
P
R
Y
--
H
----------------
Y
H
L
E
I
-
N
L
----
F
----
E
E
E
T
L
A
L
T
R
K
S
L
-----
K
D
F
-
F
N
I
N
A
-
G
I
I
E
L
--
R
-----------
N
T
R
K
L
Y
I
---
K
S
I
K
D
I
L
V
F
---------
L
E
A
--
I
G
V
Q
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
63.14
18%
-103
- C5 -
1DQ3
1
NDRZ_PYRFU
A:
[136-316]
-------------------------
F
I
F
D
Y
-
W
L
A
G
F
I
A
G
D
G
C
F
D
K
Y
-----
H
-----
S
-----
H
VKGHE
Y
I
Y
D
----
R
--
L
R
I
Y
D
Y
R
I
--
E
T
F
E
I
I
N
----
D
----
Y
L
E
-----
K
T
F
----------------------
G
---
R
K
Y
S
I
Q
K
-------
D
R
-
N
I
Y
Y
I
D
I
K
A
R
N
I
T
S
H
Y
L
K
L
-
L
E
------------
G
I
D
N
G
I
P
-
P
Q
I
L
K
E
G
K
N
A
V
L
S
F
I
A
G
L
F
D
A
E
G
----
H
V
S
N
K
P
---------------------
G
I
E
L
G
M
V
----
N
----
K
R
L
I
E
D
V
T
--
H
Y
-----
L
N
A
-
L
G
I
K
A
-
R
I
R
E
K
--
L
R
KD
G
-------
I
D
Y
V
L
H
V
---
E
E
Y
S
S
L
L
R
F
---------
Y
E
L
--
I
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
59.76
20%
-39
* C4 *
4OJV
4
PDE1_YEAST
A:
[1-369]
-----------
M
V
V
F
E
I
T
I
L
G
A
-
N
G
G
P
T
E
Y
-
G
T
Q
C
F
I
-
L
K
P
A
R
T
E
D
-----
P
-----
E
-----
L
--------
I
----
A
--
V
D
G
G
A
G
M
Y
--
Q
L
R
E
M
L
V
----
Q
GDD
E
L
V
P
-----
S
F
Y
----------------------
E
HDR
E
P
I
E
F
F
I
D
S
K
L
N
I
Q
K
G
L
S
K
S
L
L
Q
S
L
K
R
Q
--
G
E
H
F
E
S
-
A
N
T
M
K
-----
K
T
-
Y
E
V
F
Q
G
I
T
-
D
Y
Y
I
-
T
H
P
--
H
L
D
H
I
S
G
L
V
V
N
S
P
----
S
I
Y
E
Q
E
N
--
S
-------
K
--------
K
-
K
T
I
W
G
L
----
P
----
H
T
I
D
V
L
Q
K
--
H
V
-----
F
N
D
-
L
I
W
P
D
-
L
T
A
E
R
--
S
-----------
R
K
L
K
L
K
C
L
N
P
K
E
V
Q
K
C
T
I
F
P
W
D
V
I
P
F
K
V
H
H
G
--
I
G
V
K
T
G
A
P
V
Y
S
T
F
Y
I
F
R
D
-
R
K
--
S
K
D
C
I
I
V
C
G
D
V
E
Q
D
R
RES
E
E
S
L
L
E
E
F
W
S
-----------
Y
V
------
A
E
N
I
P
L
V
H
L
KGIL
V
E
C
S
C
P
L
S
S
K
P
E
Q
L
Y
G
H
L
S
P
-------
I
Y
L
I
N
E
L
S
N
L
N
T
L
Y
NS
S
K
G
L
S
G
L
N
V
I
V
T
H
V
K
S
T
P
-----
A
K
R
D
P
R
L
T
I
L
E
E
L
R
F
L
A
-
E
E
R
-
N
L
G
D
L
R
I
S
I
A
LEG
H
T
L
F
L--
20
HHSearch
54.06
15%
-64
- C5 -
2CW8
2
A:
[274-432]
------------------------
V
D
E
S
L
A
-
K
L
L
G
Y
Y
V
S
E
G
Y
A
R
K
Q
-----
R
-----
N
PKN
G
W
S
--------
Y
----
S
--
V
K
L
Y
N
E
D
P
--
E
V
L
D
D
M
E
----
R
----
L
A
S
-----
R
F
F
----------------------
G
---
K
V
R
R
-------------
G
R
N
Y
V
E
I
P
K
K
I
G
-
Y
L
L
F
E
N
-
M
C
G
--------
V
-
L
A
E
N
K
R
I
P
-
E
F
V
F
T
S
P
K
G
V
R
L
A
F
L
E
G
Y
F
I
G
D
G
----
D
V
H
P
N
------------
K
---------
R
L
R
L
S
T
K
----
S
----
E
L
L
A
N
Q
L
V
--
L
L
-----
L
N
S
-
V
G
V
S
A
-
V
K
L
G
H
--
D
S----------
G
V
Y
R
V
Y
I
---
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
52.00
17%
-88
- C5 -
3C0W
6
SCE1_YEAST
A:
[31-215]
-------------------------
I
E
Q
F
E
-
A
G
I
G
L
I
L
G
D
A
Y
I
R
S
R
-----
D
-----
E
GK---
T
--------
Y
----
C
--
M
Q
F
E
W
K
N
K
--
A
Y
M
D
H
V
C
----
L
----
L
Y
D
-----
Q
W
V
----------------------
L
---
S
P
P
H
K
K
E
R
V
N
H
-
L
-
G
N
-
L
V
I
T
W
G
A
Q
T
F
K
--
H
Q
A
F
N
K
L
A
N
L
F
I
--------
V
N
N
K
K
T
I
P
-
N
N
L
V
--
E
N
Y
L
T
P
M
S
L
A
Y
W
F
M
D
D
G
----
G
K
W
D
Y
N
K
NS
T
-------
N
--------
K
S
I
V
L
N
T
Q
----
S
FT
F
-
E
E
V
E
Y
L
V
K
--
G
L
-----
R
N
K
-
F
Q
L
N
C
-
Y
V
K
I
N
--
K
-----------
N
K
P
I
I
Y
I
----
D
S
M
S
Y
L
I
F
---------
Y
N
L
--
I
K
P
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
51.98
13%
-55
- C5 -
2DCH
3
?
X:
[10-216]
-------------
H
S
S
G
L
V
P
R
G
-
S
H
M
K
V
W
D
-
Y
L
C
G
L
I
A
A
D
G
H
L
D
E
E
-----
G
-----
Y
-----
I
--------
T
----
I
--
L
Q
---
K
D
R
--
R
F
I
D
K
I
V
----
A
----
L
L
K
-----
S
A
------------------------------
E
I
K
I
S
S
L
F
Y
D
K
G
A
-
G
V
W
K
I
K
V
K
D
--------
E
R
-
L
Y
R
Y
L
-----
V
N
-
N
G
V
I
P
G
K
V
-
L
R
P
P
-
S
S
A
V
D
P
L
W
Y
I
I
G
F
I
D
G
D
G
----
W
V
E
Q
V
V
K
--
R
AGDKSYY
Y
--------
I
R
I
G
I
K
T
K
----
S
----
K
E
L
R
D
W
I
A
--
Q
T
-----
L
N
D
-
L
G
I
R
A
-
S
R
A
D
K
--
S
-----------
D
G
Y
E
V
H
I
---
D
G
V
E
A
W
R
L
V
---------
P
H
L
--
Q
N
P
T
H
L
E
R
A
Q
S
V
K
D
N
R
L
S
L
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
50.94
13%
-93
- C5 -
1DFA
-
VATA_YEAST
A:
[204-398]
------------------------
G
P
K
V
L
A
-
Y
L
L
G
L
W
I
G
D
G
L
S
D
R
A
-------------------------------
T
--
F
S
V
D
S
R
D
T
--
S
L
M
E
R
V
T
----
E
----
Y
A
------
E
K
L
----------------------
N
---
L
C
A
E
Y
K
-----------------
N
T
E
N
P
L
-
W
D
A
I
V
G
-
L
G
F
L
K
---------
D
G
V
K
N
I
P
-
S
F
L
S
T
D
N
I
G
T
R
E
T
F
L
A
G
L
I
D
S
D
G
----
Y
V
T
D
E
----
H
-------
G
--------
I
K
A
T
I
K
T
I
----
H
----
T
S
V
R
D
G
L
V
--
S
L
-----
A
R
S
-
L
G
L
V
V
-
S
V
N
A
E
--
P
A
K
V
D
MNGTKHK
I
S
Y
A
I
Y
M
---
S
G
G
D
V
L
L
N
V
---------
L
S
K
--
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
50.44
16%
-36
- C4 -
4R6H
5
MSME_BACSU
A:
[28-421]
---------
A
D
T
A
K
K
T
L
T
I
Y
---
S
T
M
S
T
D
S
-
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
-----
H
-----
S
-----
D
--------
I
----
H
--
V
S
L
H
F
P
G
N
--
D
Y
E
N
M
M
R
----
V
----
R
M
A
A
NDLP
D
L
F
D
THGWGKIRYGEYTADLRDMKW
T
---
Q
D
L
D
P
N
L
N
S
I
L
K
N
K
S
G
-
K
V
Y
A
Y
P
I
N
Q
A
K
--
D
G
L
A
Y
N
-
R
N
I
L
D
R
Y
GIA
P
P
-
E
T
M
D
D
F
I
K
-
A
L
R
T
-
I
K
E
K
S
K
G
S
I
--
V
P
F
W
F
A
G
----
Y
-
D
K
S
S
F
--
A
-------
Q
--------
Y
Y
D
Q
F
A
T
P
----
L
LITD
P
A
H
N
E
K
K
Q
--
L
I
N
GTFQ
W
S
K
-
F
T
Y
L
S
-
E
I
L
K
Q
M
Q
K
-----------
E
K
L
I
N
I
D
---
A
V
T
A
K
K
S
Q
L
---------
I
E
L
--
M
A
Q
N
K
I
A
F
T
M
Q
G
G
T
L
G
Q
D
V
A
Q
I
N
P
N
V
K
V
G
I
I
----------
P
T
P
A
I
H
P
G
D
D
P
I
W
I
G
GER
Y
T
L
A
A
------
W
K
D
S
P
Q
L
K
E
----
A
K
D
F
I
A
F
M
A
R
P
A
N
A
K
-
Q
M
A
E
A
T
SLPSG
L
T
N
V
K
A
D
I
F
Y
A
N
D
---
Y
E
Y
Y
Q
D
V
K
V
E
P
Y
F
D
R
L
Y
L
PNG
M
W
D
V
L
G
---
T
V
G
Q
E
L
A
A
D
I
L
A
P
Q
-
D
I
S
-
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
S
E
T
22
HHSearch
50.41
16%
-92
- C5 -
1MOW
29
DMO1_DESMO (first)
A:
[6-188]
-----------------------
N
V
S
G
I
S
A
-
Y
L
L
G
L
I
W
G
D
G
G
L
Y
K
L
-----
K
Y
K
GN
R
S
-----
E
--------
Y
----
R
V
V
I
T
Q
K
S
E
N
---
L
I
K
Q
F
I
A
----
P
----
R
M
Q
F
L
I
--
D
E
L
----------------------
N
---
V
K
S
K
I
Q
I
V
K
-----
G
D
-
T
R
Y
E
L
R
V
S
S
K
K
L
Y
Y
Y
F
A
N
M
-
L
E
R
----------------
I
----
R
L
-
F
N
G
N
R
F
L
A
Y
L
A
G
I
V
D
G
D
G
----
S
I
I
A
Q
I
K
--
P
-------
N
QSYKFKHQ
L
S
L
T
F
Q
V
T
Q
KTE
R
----
R
W
F
L
D
K
L
V
--
D
E
-----
I
G
V
--
G
----
Y
V
R
D
R
--
G
-----------
S
V
S
D
Y
I
L
---
S
E
I
K
P
L
H
N
F
---------
L
T
Q
--
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
50.18
15%
-65
- C5 -
2DCH
2
?
X:
[19-198]
-----------------------
S
H
M
K
V
W
D
-
Y
L
C
G
L
I
A
A
D
G
H
L
D
E
E
-----
G
-------------------------
Y
--
I
T
I
L
Q
K
D
R
--
R
F
I
D
K
I
V
----
A
----
L
L
K
-----
S
A
-----------------------
E
---
I
K
I
S
S
L
F
Y
D
----
K
G
A
-
G
V
W
K
I
K
V
K
D
E
R
L-
Y
R
Y
L
V
N
-
N
G
V
I
P
-----
G
K
-----
V
L
R
P
-
P
S
S
---
A
V
D
P
L
W
-
Y
I
I
G
F
I
D
G
D
G
----
W
V
E
Q
V
V
K
--
R
AGDKSYY
Y
--------
I
R
I
G
I
K
T
K
----
S
----
K
E
L
R
D
W
I
A
--
Q
T
-----
L
N
D
-
L
G
I
R
A
-
S
R
A
D
K
--
S
-----------
D
G
Y
E
V
H
I
---
D
G
V
E
A
W
R
L
V
---------
P
H
L
--
Q
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
49.03
13%
-85
- C5 -
2VS7
5
DMO1_DESMO
A:
[6-182]
-----------------------
N
V
S
G
I
S
A
-
Y
L
L
G
L
I
I
G
D
G
G
L
Y
K
L
K
Y
KGN
R
-----
S
-----
E
--------
Y
----
R
--
V
V
I
T
Q
K
S
E
--
N
L
I
K
Q
H
I
A
P
L
M
Q
----
F
L
I
-----
D
E
L
----------------------
N
---
V
K
S
K
I
Q
I
V
K
-----
G
D
-
T
R
Y
E
L
R
V
S
S
K
K
L
-
Y
Y
Y
F
A
--------------------
N
M
L
-
E
R
I
R
L
F
N
M
R
E
Q
I
A
F
I
K
G
L
Y
V
A
E
G
----
D
K
T
L
-
K
---------------------
R
L
R
I
W
N
K
----
N
----
K
A
L
L
E
I
V
S
--
R
W
-----
L
N
N
-
L
G
V
R
N
-
T
I
H
L
D
--
D
HRH--------
G
V
Y
V
L
N
I
----
S
L
R
D
R
I
K
F
---------
V
H
T
--
I
L
S
S
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
46.21
17%
-4
* C6 *
4BVA
3
CRYM_MOUSE
A:
[24-334]
K
R
A
P
A
F
L
S
-
A
E
E
V
Q
D
H
L
R
S
S
S
L
-
L
I
P
P
L
E
A
-
A
L
A
N
F
S
K
G
P
D
G
---------------------
G
--------
V
----
M
--
Q
P
V
R
T
V
V
P
--
V
A
K
H
R
G
F
----
L
----
G
V
M
-----
P
A
Y
----------------------
S
---
A
A
E
D
A
L
T
T
K
L
V
T
F
Y
E
S
-
H
Q
A
S
V
L
L
F
D
P
S
--
N
G
-------------------
S
L
L
A
V
M
D
G
N
V
I
T
-
A
K
R
T
A
A
V
S
A
I
A
T
K
L
L
K
P
P
----
G
S
D
V
L
C
I
--
L
-------
G
--------
A
G
V
Q
A
Y
S
H
----
Y
----
E
I
F
T
E
Q
F
----
S
-----
F
K
E
-
V
R
M
W
N
-
R
T
R
E
N
--
A
-----------
E
K
F
A
S
T
V
---
Q
G
D
---------------
V
R
V
--
C
S
S
V
Q
E
A
V
T
G
A
D
V
I
I
T
V
T
M
----
A
T
E
P
I
L
F
G
----------
E
W
V
K
P
G
A
H
I
N
-----------
A
V
GASRPD
W
R
E
L
D
D
E
L
M
----
R
Q
A
V
L
Y
V
D
S
R
E
A
A
L
K
-
E
S
G
D
-------
V
L
L
S
G
A
D
I
-
F
A
E
L
---
G
E
V
I
S
G
A
K
P
A
H
C
E
K
T
T
V
F
-----
K
S
L
G
---
M
A
V
E
D
L
V
A
A
K
-
L
V
Y
-
D
S
W
-
S
S
G
-------------
5
PsiBlast_PDB
45.83
25%
-23
- C5 -
1SFF
2
GABT_ECOLI
A:
[178-362]
---------------------
I
-
S
E
D
D
A
I
A
-
S
I
H
R
I
F
K
N
D
A
A
P
E
D
I
-----
A
-----
A
-----
I
--------
V
----
I
--
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
----
Q
----
R
L
R
-----
A
L
C
----------------------
D
----------
E
H
G
I
M
L
I
A
D
-
E
V
Q
S
G
A
G
R
T
G
T
--
L
F
A
M
E
Q
-
M
G
V
A
P
-----
D
L
-
T
T
F
A
K
S
I
A
-
G
G
F
P
-
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
LGGT
Y
A
G
N
P
I
A
--
C
-------
V
--------
A
A
L
E
V
L
K
V
----
F
----
E
Q
E
N
------
L
L
-----
Q
K
A
-
N
D
L
G
Q
-
K
L
-----
K
-----------
D
G
L
L
A
I
------
A
E
K
H
P
E
I
---------
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
45.74
15%
-10
- C3 -
4X2Z
1
A:
[9-309]
----Q
K
T
I
Y
L
T
E
D
G
V
K
Y
R
S
I
V
L
-
K
P
G
D
S
L
G
-
Q
F
G
Q
-
V
Y
A
K
N
K
I
V
F
T
-----
A
-----
D
-----
D
--------
V
EDK
E
I
--
L
Y
V
P
T
T
D
K
--
S
I
L
E
Y
Y
-----
G
----
L
D
A
-----
Q
K
Y
----------------------
V
---
I
Y
L
Q
T
L
A
Q
K
W
N
V
Q
Y
R
D
-
N
F
L
I
L
E
W
R
D
G
N
--
C
W
I
S
S
A
-
I
V
L
L
Q
-----
A
A
K
I
R
F
K
G
F
L
T
-
E
A
W
A
-
K
L
L
G
G
D
P
T
D
F
V
A
W
C
Y
A
S
C
----
T
A
K
V
G
D
--------------------------------
F
----
S
D
A
N
W
L
L
A
--
N
L
-----
A
E
H
-
F
D
A
D
------
Y
--
T
-----------
N
A
F
L
K
K
R
---
V
S
C
N
C
G
I
K
S
---------
Y
E
L
--
R
G
L
E
A
C
I
Q
P
V
R
A
T
N
-
L
L
H
F
K
T
--
Q
Y
S
N
C
P
T
C
----------
G
A
N
N
T
D
E
V
I
E
-----------
A
------------
S
L
P
Y
----
L
L
L
F
A
T
D
G
P
A
T
V
D
C
D
-
E
D
A
V
-------
G
T
V
V
F
V
G
S
T
--
N
S
---
G
H
C
Y
T
--
Q
A
A
G
Q
A
F
D
N
-
L
-----
A
K
D
R
---
K
F
G
K
--
K
S
P
Y
-
I
T
A
M
Y
T
R
-
F
A
F
K
N
E
TS--------
3
PsiBlast_PDB
45.59
25%
-25
- C5 -
1SZS
3
GABT_ECOLI
A:
[178-362]
---------------------
I
-
S
E
D
D
A
I
A
-
S
I
H
R
I
F
K
N
D
A
A
P
E
D
I
-----
A
-----
A
-----
I
--------
V
----
I
--
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
----
Q
----
R
L
R
-----
A
L
C
----------------------
D
----------
E
H
G
I
M
L
I
A
D
-
E
V
Q
S
G
A
G
R
T
G
T
--
L
F
A
M
E
Q
-
M
G
V
A
P
-----
D
L
-
T
T
F
A
K
S
I
A
-
G
G
F
P
-
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
LGGT
Y
A
G
N
P
I
A
--
C
-------
V
--------
A
A
L
E
V
L
K
V
----
F
----
E
Q
E
N
------
L
L
-----
Q
K
A
-
N
D
L
G
Q
-
K
L
-----
K
-----------
D
G
L
L
A
I
------
A
E
K
H
P
E
I
---------
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.25
25%
-24
- C5 -
1SF2
4
GABT_ECOLI
A:
[178-362]
---------------------
I
-
S
E
D
D
A
I
A
-
S
I
H
R
I
F
K
N
D
A
A
P
E
D
I
-----
A
-----
A
-----
I
--------
V
----
I
--
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
----
Q
----
R
L
R
-----
A
L
C
----------------------
D
----------
E
H
G
I
M
L
I
A
D
-
E
V
Q
S
G
A
G
R
T
G
T
--
L
F
A
M
E
Q
-
M
G
V
A
P
-----
D
L
-
T
T
F
A
K
S
I
A
-
G
G
F
P
-
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
LGGT
Y
A
G
N
P
I
A
--
C
-------
V
--------
A
A
L
E
V
L
K
V
----
F
----
E
Q
E
N
------
L
L
-----
Q
K
A
-
N
D
L
G
Q
-
K
L
-----
K
-----------
D
G
L
L
A
I
------
A
E
K
H
P
E
I
---------
G
D
V
RG
L
G
A
M
I
A
I
E
L
F
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
42.90
18%
-82
- C5 -
2DCH
-
?
X:
[23-100]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
W
D
Y
L
C
G
L
I
A
A
D
G
----
H
L
D
E
E
------------
G
---------
Y
I
T
I
L
Q
K
----
D
----
R
R
F
I
D
K
I
V
--
A
L
-----
L
K
S
-
A
E
I
K
I
S
S
L
F
Y
D
KG
A
-----------
G
V
W
K
I
K
V
---
K
-
D
E
R
L
Y
R
Y
---------
L
V
N
--
N
G
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------