@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2500: (2016-04-04 )
MKKLWLKIGLSFFILFFVVMVIVGIFSGELMKSTYLNMKENQLEDDAKILLQTTNMENLDLDKDAATIQKSLDPLGEDIDARITVIDSKGDVVADTKKDPEKLDNHMNRPEVTDILKKGESVGISIRESDSLGYSMLYVAVPVKHQSKTDGVLRISISLESVDAAVAKLWGNLALIFGIALVIIAAISVFIARKITRPVREIIEVSTDLANHKYDSRIHGKISGELQDLSISVNTLAESLETQMFEIKQNEQRLNAIVQNLVSGVMLINVDKQVIMTNRTMYQILGETEITGKPFYEVIKSFALSQLIEATFETKTIQQKEIILYFPREMILDASVSPILGENGEITGIILLLHDITQIRHLENVRSEFVTNVSHELKTPVTALKGFAETLLDGAMYDEMLLKKFLTIIKEESDRLHRLIMDILALSRIEQNPVPENVELVEVDEVIEQSARTIFEMATEKNIQVIIPEKTIPSVTIETDRDKLQQILINLLSNAINYTPVDGKVEVKLIEQEAEVIIEVTDNGIGIPAKDIDRVFERFYRVDKARSRHSGGTGLGLSIVKHLVENCGGRIEVESQEEVGSTFRVTLPKKA
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280....--..--.--290.-----......--300.........310.......320......--.330.......340...-.-...350.......360.---------..---------....370.......380.......390..-...-..400.......410.......420.......430.--......440----.-......450.......460.-----....--...470.......480.......490.......500.---.---.--....510-........520.......530.......540.......550.......560...-.-...570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
L
W
L
K
I
G
L
S
F
F
I
L
F
F
V
V
M
V
I
V
G
IFS
G
E
L
M
K
S
T
YLNMKENQLED
D
A
K
I
L
L
Q
TTNMENLDLD
K
D
A
A
T
I
Q
K
S
LDPLGEDID
A
R
I
T
V
IDSKG
D
V
VADTKK
D
P
E
K
L
D
N
HMN
R
P
E
V
T
D
I
L
KKGESV
G
I
S
I
RESDSLG
Y
S
M
L
Y
V
A
V
PVKHQSKTD
G
V
L
R
I
S
I
S
L
E
S
V
D
A
A
V
A
K
L
W
G
N
L
A
L
I
F
G
I
A
L
V
I
I
A
A
I
S
V
F
I
A
R
K
I
T
R
P
V
R
E
I
I
E
V
S
T
D
L
ANHKYD
S
R
I
H
G
K
ISGE
L
Q
D
L
S
I
S
V
N
T
L
A
E
S
L
E
T
Q
M
F
E
I
K
Q
N
E
Q
R
L
N
A
I
V
Q
N
L
VS
G
V
M
L
I
NVDK
Q
V
I
MTN
R
T
M
Y
Q
ILG--ET--E--ITGK-----
P
F
Y
E
V
I
--
K
--
S
F
A
L
S
Q
L
I
E
A
T
FETKTIQQK
E
I
I
L
Y
F
P
R
--
E
M
ILDASVSPILGENG
E
-
I
-
T
G
I
I
L
L
L
H
D
I
T
Q
I
R
H
L
E
---------
N
V
---------
R
S
E
F
V
T
N
V
S
H
E
LKT
P
V
T
A
L
K
G
F
A
E
T
L
LD
G
-
A
M
Y
-
D
E
M
L
L
K
K
F
L
T
I
I
KEE
S
D
R
L
H
R
L
I
M
D
I
L
A
L
S
R
I
EQNP--VPEN
V
E
L
V
E
----
V
-
D
E
V
I
E
Q
S
A
R
T
I
F
E
M
ATE-K
N
-----
I
Q
V
I
--
I
PEKTI
P
S
V
T
I
ET
D
R
D
K
L
Q
Q
I
L
I
N
L
L
S
NAINYTPVD
G
---
K
---
V
--
E
V
K
L
I
E--QE
A
E
V
I
I
E
VTDNGIGI
P
A
K
D
I
D
R
V
F
E
R
F
Y
R
V
D
K
ARSRHSGGT
G
L
G
L
S
I
V
K
H
L
V
E
-N-CG
G
R
I
E
V
E
S
Q
E
EVG
S
T
F
R
V
TLPKKA
2
PsiBlast_PDB
83.79
43%
-82
- C4 -
4U7O
1
?
A:
[25-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
---------
N
D
---------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
-
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
--
T
R
V
D
M
E
L
V
N
----
I
-
N
E
M
F
-
N
Y
V
L
D
R
F
D
M
I
L
K
-
K
D
DNPA
K
Y
Y
T
I
--
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
-
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
6
PsiBlast_PDB
83.29
38%
-87
- C4 -
4JAV
6
?
A:
[9-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
65
Fugue
82.25
31%
-66
* C6 *
4I5S
-
?
A:
[37-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
VT
R
E
--
Q
--
A
L
E
C
-----
N
I
L
D
I
L
DD
D
--
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
----
Y
D
E
--
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
-
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
---------
R
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
-
A
L
T
-
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
L
D
V
-------
E
L
T
N
----
F
-
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-
Q
S
-----
T
E
-
I
--
I
R
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
--
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
-
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
1
PsiBlast_PDB
81.92
43%
-83
- C4 -
4U7N
-
?
A:
[39-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
-
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
--
T
R
V
D
M
E
L
V
N
----
I
-
N
E
M
F
-
N
Y
V
L
D
R
F
D
M
I
L
K
-
K
D
DN---
Y
Y
T
I
--
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
-
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
23
PsiBlast_CBE
81.52
38%
-79
- C4 -
3DGE
2
?
B:
[14-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
DKY
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
22
PsiBlast_CBE
81.05
38%
-87
- C4 -
4JAV
6
?
B:
[9-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
8
PsiBlast_PDB
80.83
38%
-93
- C4 -
4JAU
1
?
A:
[9-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
5
PsiBlast_PDB
79.57
38%
-82
- C4 -
3DGE
3
?
A:
[14-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
21
PsiBlast_CBE
78.63
43%
-73
- C4 -
4U7O
1
?
B:
[37-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
-
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
--------
T
R
V
D
M
E
L
V
N
----
I
-
N
E
M
F
-
N
Y
V
L
D
R
F
D
M
I
L
K
-
K
D
DNPAK
Y
Y
T
I
--
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
-
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
7
PsiBlast_PDB
77.95
38%
-78
- C4 -
4JAS
2
?
A:
[13-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
45
HHSearch
77.92
41%
-83
- C4 -
2C2A
2
?
A:
[18-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
-
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
---
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-
4
PsiBlast_PDB
77.15
38%
-89
- C4 -
2C2A
2
?
A:
[9-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
D
---------
R
M
---------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
--
L
Q
I
N
R
E
K
V
D
----
L
-
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
--
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
-
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
--
3
PsiBlast_PDB
75.51
33%
-64
- C6 -
4I5S
-
?
A:
[56-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
--
V
T
RE
Q
--
A
L
E
C
-----
N
I
L
D
I
L
--
D
DD
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
----
Y
D
E
--
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
-
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
---------
R
E
---------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
-
A
L
--
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-------
S
H
L
D
V
E
L
T
N
F
T
A
F
M
-
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
S
T
----------
E
I
I
R
D
Y
P
D
K
---
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
--
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
-
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
10
PsiBlast_PDB
68.07
30%
-71
- C4 -
4Q20
-
DIVL_CAUCR
A:
[37-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------
R
L
---------
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
-
L
L
E
R
-
A
D
---
S
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
--
M
A
L
E
I
E
D
I
R
----
V
-
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
-
G
G
-----
V
T
L
A
--
V
-
E
C
E
E
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
G
---
R
---
V
--
T
L
S
A
R
R
--
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
------
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
-
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
--
11
PsiBlast_PDB
68.05
26%
-82
- C4 -
3A0R
1
?
A:
[12-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
LK
K
E
--
N
--
V
L
G
R
RLKDL
P
D
F
E
E
I
--
G
--
S
V
A
-----
E
S
V
F
E
N
K
----
E
P
V
F
L
N
F
Y
K
FG
E
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
-
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
E
R
K
R
R
E
R
L
S
I
---------
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
-
M
R
M
K
K
-
H
L
D
-
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
-----
V
L
E
F
T
E
F
-
N
----
L
-
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
-
M
N
-----
I
D
F
C
--
F
-
E
T
D
N
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
---
I
--
K
I
T
S
E
D
--
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
------
T
T
------
L
G
L
S
I
C
R
K
I
I
E
-
D
E
H
G
G
K
I
W
T
E
N
R
E
N
-
G
V
V
F
I
F
E
I
P
K
--
43
HHSearch
67.39
26%
-79
- C4 -
3A0R
1
?
A:
[9-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
--
L
K
--
K
EN
V
L
G
R
-----
R
L
K
D
L
P
--
D
--
F
E
E
I
G
S
V
A
E
S
V
F
E
N
K
E
P
--
V
F
L
N
F
Y
K
F
G
--
E
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
L
L
-
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
---------
E
E
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
-
L
D
--
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
------
V
L
E
F
T
E
F
N
----
L
-
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
-
M
N
-----
I
D
F
C
--
F
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
---
I
--
K
I
T
S
E
D
--
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------
L
G
L
S
I
C
R
K
I
I
E
D
E
-
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
-
18
PsiBlast_PDB
63.82
29%
-60
- C4 -
4BIV
2
CPXA_ECOLI
A:
[70-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
---------
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
R
-
R
S
G
-
E
S
K
E
L
E
R
----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
----
L
W
S
E
V
L
D
N
A
A
---
F
E
A
E
Q
M
G
K
S
-----
L
T
V
N
--
F
P
P
G
P
W
P
---
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
-----
K
---
I
--
E
V
G
F
A
V
--
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
-
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
14
PsiBlast_PDB
63.60
29%
-54
- C4 -
4BIW
5
CPXA_ECOLI
A:
[70-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
---------
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
R
-
R
S
G
-
E
S
K
E
L
E
R
----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
----
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
---
K
S
-----
L
T
V
N
--
F
P
P
G
P
W
P
---
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
-----
K
---
I
--
E
V
G
F
A
V
--
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
-
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
19
PsiBlast_PDB
63.42
29%
-49
- C4 -
4CB0
6
CPXA_ECOLI
A:
[70-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
---------
T
S
---------
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
R
-
R
S
G
-
E
S
K
E
L
E
R
----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
AL
V
S
E
T
I
K
A
N
Q
----
L
W
S
E
V
L
D
N
A
A
---
F
E
A
E
Q
M
G
K
S
-----
L
T
V
N
--
F
P
P
G
P
W
P
---
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
-----
K
---
I
--
E
V
G
F
A
V
--
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
-
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
12
PsiBlast_PDB
63.11
26%
-70
- C4 -
3D36
4
?
A:
[3-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
I
R
----------------------------
L
A
A
S
I
S
H
E
I
R
N
P
L
T
A
A
R
G
F
I
Q
L
I
E
E
Q
-
P
L
A
-
A
D
K
R
-
R
Q
Y
A
R
I
A
I
E
E
L
D
R
A
E
A
I
I
T
D
Y
L
T
F
A
K
----
P
--
A
P
E
T
P
E
K
L
N
----
V
-
K
L
E
I
E
R
V
I
D
I
L
R
P
L
A
----
N
-----
M
S
C
V
--
D
I
Q
A
T
L
A
P
F
S
V
I
G
E
R
E
K
F
R
Q
C
L
L
N
V
M
K
N
A
I
E
A
M
P
N
G
G
---
T
---
L
--
Q
V
Y
V
S
I
--
D
N
G
R
V
L
I
R
I
A
D
T
G
V
G
M
T
K
E
Q
L
E
R
L
G
E
P
Y
F
T
T
K
G
V
K
-----
G
T
G
L
G
M
M
V
V
Y
R
I
I
E
-
S
-
M
N
G
T
I
R
I
E
S
E
I
H
K
G
T
T
V
S
I
Y
L
P
---
52
HHSearch
58.31
41%
-66
- C4 -
3SL2
2
A:
[3-152]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
----
I
-
V
R
F
M
S
L
I
I
D
R
F
E
M
T
-
K
E
-
Q
-------
E
F
I
--
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
---
V
--
T
F
S
I
D
V
NE
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
-
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
-
9
PsiBlast_PDB
53.82
46%
-52
- C4 -
3SL2
2
A:
[16-152]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
T
K
E
-
Q
-------
E
F
I
RN
L
P
D
R
---
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
---
V
T
F
S
I
D
V
N
E
--
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
-
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
-