@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2552: (2016-04-04 )
VTDRLIIQGGKKLSGTLQVDGAKNSAVALIPAAILAESEVVLEGLPDISDVYTLYDILEELGGSVRYDNKTAIIDPTDMLSMPLPSGNVKKLRASYYLMGAMLGRFKKAVIGLPGGCYLGPRPIDQHIKGFEALGAKVTNEQGAIYLRADELKGARIYLDVVSVGATINIMLAAVRAKGKTVIENAAKEPEIIDVATLLTNMGAIIKGAGTDTIRITGVDHLHGCHHTIIPDRIEAGTFMVLAAASGKGIRIENVIPTHLEGIIAKLTEMGVPMDIEEDSIFIGEVENIKKVDIKTYAYPGFPTDLQQPLTALLTRAEGSSVITDTIYPSRFKHIAELERMGGKFKLEGRSAVISGPAKLQGSKVTATDLRAGAALVIAGLLAEGRTEIHGVEHIERGYSKIIEKLSAIGADITRSSTAETNI
Atome Classification :
(22 SA)
.........10.-.......20........30.....-...40........50........60........70..-.-.....80........90........100.......110.......120.......130.......140......--.---150-.--........160.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..-..-..-.-290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VT
D
R
L
I
IQGGKK-L
S
G
T
L
Q
VDGAKNS
A
V
A
L
I
P
A
A
I
LA-E
S
E
V
V
L
EGLP
D
I
S
D
V
Y
T
L
Y
D
I
L
E
ELGG
S
V
RYDN
K
T
A
I
-I-DP
T
D
M
LSMPLPSG
N
V
K
K
L
R
A
S
Y
Y
L
M
G
A
M
L
G
R
F
K
K
A
V
IGLPGGCYLG
P
R
P
I
D
Q
H
I
K
G
F
E
A
LG
A
K
VTNEQ
G
A
I
Y
L
R--A---D---E--LKG
A
R
I
Y
L
D
--
V
V
SVG
A
T
I
N
I
M
L
A
A
V
RAK
G
K
T
V
I
E
NAAKEP
E
I
I
D
V
A
T
L
L
T
N
M
G
A
I
I
KGAGT
D
T
I
R
I
TGVDHLHGCHHTIIPDRIEA
G
T
F
M
V
L
A
AASGK
G
I
R
I
ENV
I
P
T
H
L
E
G
I
I
A
K
L
T
EMGVPMDIEED
S
I
F
I
G-EV-E
N
-
I
-
K
K
V
D
I
K
T
YAYPGF
P
T
D
L
Q
Q
P
L
T
A
L
L
T
RAEGS
S
V
I
TDTI
Y
P
S
R
F
K
H
I
A
E
L
E
RMG
G
K
F
K
LEGR
S
A
V
ISGPAKLQGS
K
V
T
A
T
D
LRA
G
A
A
L
V
I
A
G
L
L
AEGRTEIH
G
V
E
H
I
E
R
G
Y
S
K
I
I
E
K
L
S
A
IGADITRSSTAETNI
2
PsiBlast_PDB
94.73
58%
-111
- C7 -
3ZH3
-
?
A:
[3-414]
---
K
I
V
I
N
G
G
L
P
-
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
I
L
A
-
D
D
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
Y
D
D
V
L
E
-
I
-
D
P
R
G
V
Q
N
I
P
M
P
Y
G
K
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
P
-------
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
--
A
---
K
---
D
T
G
L
H
G
A
S
I
Y
M
D
--
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
E
R
L
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
I
R
I
N
N
V
L
Y
E
H
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
-
E
Q
-
S
N
-
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
L
Y
T
G
G
R
D
L
R
G
A
S
V
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
----------
3
PsiBlast_PDB
94.31
51%
-104
- C7 -
3SG1
-
MURA1_BACAN
A:
[26-440]
--
E
K
I
I
V
R
G
G
K
R
-
L
N
G
T
V
R
V
E
G
A
K
N
A
V
L
P
I
I
A
A
A
L
L
A
S
D
G
K
N
V
L
S
E
V
P
V
L
S
D
V
Y
T
I
N
E
V
L
R
H
L
N
A
E
V
V
F
E
N
N
Q
V
T
-
I
-
D
A
S
K
E
L
N
I
E
A
P
F
E
Y
V
R
K
M
R
A
S
V
Q
V
M
G
P
L
L
A
R
N
G
R
A
R
I
A
L
P
G
G
C
A
I
G
S
R
P
I
D
Q
H
L
K
G
F
E
A
M
G
A
K
V
Q
V
G
N
G
F
V
E
A
Y
--
V
---
E
G--
E
--
L
K
G
A
K
I
Y
L
D
--
F
P
S
V
G
A
T
E
N
I
M
S
A
A
T
L
A
K
G
T
T
I
L
E
N
A
A
K
E
P
E
I
V
D
L
A
N
F
L
N
A
M
G
A
K
V
R
G
A
G
T
G
T
I
R
I
E
G
V
D
K
L
Y
G
A
N
H
S
I
I
P
D
R
I
E
A
G
T
F
M
V
A
A
A
I
T
G
G
D
I
L
I
E
N
A
V
P
E
H
L
R
S
I
T
A
K
M
E
E
M
G
V
K
I
I
E
E
N
E
G
V
R
V
I
-
G
P
-
D
K
-
L
-
K
A
V
D
I
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
A
L
L
L
Q
A
D
G
T
S
M
I
T
E
T
V
F
E
N
R
F
M
H
V
E
E
F
R
R
M
N
A
D
I
K
I
E
G
R
S
V
I
M
N
G
P
N
S
L
Q
G
A
E
V
G
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
S
E
G
Y
T
R
V
T
E
L
K
H
L
D
R
G
Y
V
D
F
H
K
K
L
A
A
L
G
A
T
I
E
R
--------
21
PsiBlast_CBE
93.63
51%
-105
- C7 -
3SG1
2
MURA1_BACAN
B:
[26-440]
--
E
K
I
I
V
R
G
G
K
R
-
L
N
G
T
V
R
V
E
G
A
K
N
A
V
L
P
I
I
A
A
A
L
L
A
S
D
G
K
N
V
L
S
E
V
P
V
L
S
D
V
Y
T
I
N
E
V
L
R
H
L
N
A
E
V
V
F
E
N
N
Q
V
T
-
I
-
D
A
S
K
E
L
N
I
E
A
P
F
E
Y
V
R
K
M
R
A
S
V
Q
V
M
G
P
L
L
A
R
N
G
R
A
R
I
A
L
P
G
G
C
A
I
G
S
R
P
I
D
Q
H
L
K
G
F
E
A
M
G
A
K
V
Q
V
G
N
G
F
V
E
A
Y
--
V
---
E
G--
E
--
L
K
G
A
K
I
Y
L
D
--
F
P
S
V
G
A
T
E
N
I
M
S
A
A
T
L
A
K
G
T
T
I
L
E
N
A
A
K
E
P
E
I
V
D
L
A
N
F
L
N
A
M
G
A
K
V
R
G
A
G
T
G
T
I
R
I
E
G
V
D
K
L
Y
G
A
N
H
S
I
I
P
D
R
I
E
A
G
T
F
M
V
A
A
A
I
T
G
G
D
I
L
I
E
N
A
V
P
E
H
L
R
S
I
T
A
K
M
E
E
M
G
V
K
I
I
E
E
N
E
G
V
R
V
I
-
G
P
-
D
K
-
L
-
K
A
V
D
I
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
A
L
L
L
Q
A
D
G
T
S
M
I
T
E
T
V
F
E
N
R
F
M
H
V
E
E
F
R
R
M
N
A
D
I
K
I
E
G
R
S
V
I
M
N
G
P
N
S
L
Q
G
A
E
V
G
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
S
E
G
Y
T
R
V
T
E
L
K
H
L
D
R
G
Y
V
D
F
H
K
K
L
A
A
L
G
A
T
I
E
R
--------
1
PsiBlast_PDB
92.99
58%
-114
- C7 -
3ZH4
2
?
A:
[3-414]
---
K
I
V
I
N
G
G
L
P
-
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
I
L
A
-
D
D
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
Y
D
D
V
L
E
-
I
-
D
P
R
G
V
Q
N
I
P
M
P
---
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
--
A
---
K
---
D
T
G
L
H
G
A
S
I
Y
M
D
--
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
E
R
L
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
I
R
I
N
N
V
L
Y
E
H
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
-
E
Q
-
S
N
-
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
L
Y
T
G
G
R
D
L
R
G
T
S
V
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
----------
46
HHSearch
92.79
57%
-112
- C7 -
3ZH4
2
?
A:
[1-418]
-
M
R
K
I
V
I
N
G
G
L
P
-
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
I
L
A
-
D
D
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
Y
D
D
V
L
E
-
I
-
D
P
R
G
V
Q
N
I
P
M
P
---
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
A
K
D
---
T
---
G
--
L
H
G
A
S
I
Y
M
D
--
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
E
R
L
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
I
R
I
N
N
V
L
Y
E
H
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
-
E
Q
-
S
N
-
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
L
Y
T
G
G
R
D
L
R
G
T
S
V
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
------
9
PsiBlast_PDB
90.81
44%
-99
- C7 -
1UAE
2
MURA_ECOLI
A:
[2-415]
--
D
K
F
R
V
Q
G
P
T
K
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
E
R
-
N
G
S
V
H
-
I
-
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
S
--
V
---
D
G
--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
G
Q
G
T
D
R
I
V
I
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
D
A
G
A
D
I
E
V
G
E
D
W
I
S
L
D
M
H
G
-
K
R
-
P
-
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
--------
5
PsiBlast_PDB
90.47
45%
-97
- C7 -
2RL1
2
MURA_HAEIN
A:
[2-419]
--
D
K
F
R
V
Y
G
Q
S
R
-
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
I
L
A
-
T
E
P
V
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
D
R
D
A
T
G
A
V
-
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
E
E
G
--
Y
V
K
--
A
Q
V
S
D
---
R
--
L
V
G
T
R
I
V
I
E
--
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
S
A
H
I
T
I
E
G
V
E
R
L
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
L
I
A
A
A
I
S
G
G
C
V
V
C
Q
N
T
K
A
D
T
L
D
A
V
I
D
K
L
R
E
A
G
A
Q
V
D
V
T
E
N
S
I
T
L
D
-
M
L
-
G
N
-
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
V
C
H
G
V
E
Q
L
S
G
T
E
V
I
A
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
E
R
F
S
------
31
PsiBlast_CBE
90.39
42%
-105
- C7 -
5BQ2
2
?
B:
[10-426]
--
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
D
E
K
L
N
V
E
V
-
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
E
G
G
Y
I
K
A
K
--
A
---
P
---
A
GG
L
R
G
G
H
F
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
S
D
T
I
V
I
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
H
I
S
T
G
S
N
W
I
E
L
D
-
M
K
-
G
N
R
P
-
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
--------
13
PsiBlast_PDB
90.35
43%
-99
- C7 -
1A2N
1
MURA_ECOLI
A:
[2-415]
--
D
K
F
R
V
Q
G
P
T
K
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
E
R
-
N
G
S
V
H
-
I
-
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
A
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
S
--
V
---
D
G
--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
G
Q
G
T
D
R
I
V
I
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
D
A
G
A
D
I
E
V
G
E
D
W
I
S
L
D
M
H
G
-
K
R
-
P
-
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
--------
29
PsiBlast_CBE
90.15
42%
-105
- C7 -
5BQ2
3
?
D:
[10-426]
--
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
D
E
K
L
N
V
E
V
-
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
E
G
G
Y
I
K
A
K
--
A
---
P
---
A
GG
L
R
G
G
H
F
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
S
D
T
I
V
I
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
H
I
S
T
G
S
N
W
I
E
L
D
-
M
K
-
G
N
R
P
-
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
--------
6
PsiBlast_PDB
90.10
45%
-95
- C7 -
2RL2
5
MURA_HAEIN
A:
[2-419]
--
D
K
F
R
V
Y
G
Q
S
R
-
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
I
L
A
-
T
E
P
V
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
D
R
D
A
T
G
A
V
-
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
E
E
G
--
Y
V
K
--
A
Q
V
S
D
---
R
--
L
V
G
T
R
I
V
I
E
--
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
S
A
H
I
T
I
E
G
V
E
R
L
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
L
I
A
A
A
I
S
G
G
C
V
V
C
Q
N
T
K
A
D
T
L
D
A
V
I
D
K
L
R
E
A
G
A
Q
V
D
V
T
E
N
S
I
T
L
D
-
M
L
-
G
N
-
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
V
C
H
G
V
E
Q
L
S
G
T
E
V
I
A
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
E
R
F
S
------
47
HHSearch
89.92
47%
-103
- C7 -
3R38
10
MURA1_LISMO
A:
[25-442]
-
M
E
K
I
I
V
R
G
G
K
Q
-
L
N
G
S
V
K
M
E
G
A
K
N
A
V
L
P
V
I
A
A
T
L
L
A
S
K
G
T
S
V
L
K
N
V
P
N
L
S
D
V
F
T
I
N
E
V
L
K
Y
L
N
A
D
V
S
F
V
N
D
E
V
T
-
V
-
D
A
T
G
E
I
T
S
D
A
P
F
E
Y
V
R
K
M
R
A
S
I
V
V
M
G
P
L
L
A
R
T
G
S
A
R
V
A
L
P
G
G
C
A
I
G
S
R
P
V
D
L
H
L
K
G
F
E
A
M
G
A
V
V
K
I
E
N
G
Y
I
E
A
T
--
A
---
E
---
K
--
L
V
G
A
K
V
Y
L
D
--
F
P
S
V
G
A
T
Q
N
I
M
M
A
A
T
L
A
E
G
T
T
V
I
E
N
V
A
R
E
P
E
I
V
D
L
A
N
F
L
N
Q
M
G
A
R
V
I
G
A
G
T
E
V
I
R
I
E
G
V
K
E
L
T
A
T
E
H
S
I
I
P
D
R
I
E
A
G
T
F
M
I
A
A
A
I
T
G
G
N
V
L
I
E
D
A
V
P
E
H
I
S
S
L
I
A
K
L
E
E
M
G
V
Q
I
I
E
E
--
G
I
R
V
I
-
G
P
-
D
K
-
L
-
K
A
V
D
V
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
V
I
Q
M
L
S
E
G
T
S
I
M
T
E
T
V
F
E
N
R
F
M
H
V
E
E
M
R
R
M
N
A
D
M
K
I
E
G
H
S
V
I
I
S
G
P
A
K
L
Q
G
A
E
V
A
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
A
D
G
Y
T
Q
V
T
E
L
K
Y
L
D
R
G
Y
N
N
F
H
G
K
L
Q
A
L
G
A
D
V
E
R
V
D
D
-----
4
PsiBlast_PDB
89.67
46%
-102
- C7 -
3R38
10
MURA1_LISMO
A:
[26-447]
--
E
K
I
I
V
R
G
G
K
Q
-
L
N
G
S
V
K
M
E
G
A
K
N
A
V
L
P
V
I
A
A
T
L
L
A
S
K
G
T
S
V
L
K
N
V
P
N
L
S
D
V
F
T
I
N
E
V
L
K
Y
L
N
A
D
V
S
F
V
N
D
E
V
T
-
V
-
D
A
T
G
E
I
T
S
D
A
P
F
E
Y
V
R
K
M
R
A
S
I
V
V
M
G
P
L
L
A
R
T
G
S
A
R
V
A
L
P
G
G
C
A
I
G
S
R
P
V
D
L
H
L
K
G
F
E
A
M
G
A
V
V
K
I
E
N
G
Y
I
E
A
T
--
A
---
E
---
K
--
L
V
G
A
K
V
Y
L
D
--
F
P
S
V
G
A
T
Q
N
I
M
M
A
A
T
L
A
E
G
T
T
V
I
E
N
V
A
R
E
P
E
I
V
D
L
A
N
F
L
N
Q
M
G
A
R
V
I
G
A
G
T
E
V
I
R
I
E
G
V
K
E
L
T
A
T
E
H
S
I
I
P
D
R
I
E
A
G
T
F
M
I
A
A
A
I
T
G
G
N
V
L
I
E
D
A
V
P
E
H
I
S
S
L
I
A
K
L
E
E
M
G
V
Q
I
I
E
E
--
G
I
R
V
I
-
G
P
-
D
K
-
L
-
K
A
V
D
V
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
V
I
Q
M
L
S
E
G
T
S
I
M
T
E
T
V
F
E
N
R
F
M
H
V
E
E
M
R
R
M
N
A
D
M
K
I
E
G
H
S
V
I
I
S
G
P
A
K
L
Q
G
A
E
V
A
A
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
A
D
G
Y
T
Q
V
T
E
L
K
Y
L
D
R
G
Y
N
N
F
H
G
K
L
Q
A
L
G
A
D
V
E
R
V
D
D
S
K
V
D
V
10
PsiBlast_PDB
89.27
42%
-104
- C7 -
5BQ2
2
?
A:
[10-426]
--
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
D
E
K
L
N
V
E
V
-
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
-
A
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
E
G
G
Y
I
K
A
K
--
A
---
P
---
A
G
G
L
R
G
G
H
F
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
S
D
T
I
V
I
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
H
I
S
T
G
S
N
W
I
E
L
D
-
M
K
-
G
N
R
P
-
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
--------
30
PsiBlast_CBE
89.25
42%
-104
- C7 -
5BQ2
3
?
C:
[10-426]
--
D
K
L
I
I
T
G
G
N
R
-
L
D
G
E
I
R
I
S
G
A
K
N
S
A
L
P
I
L
A
A
T
L
L
A
-
D
T
P
V
T
V
C
N
L
P
H
L
H
D
I
T
T
M
I
E
L
F
G
R
M
G
V
Q
P
I
I
D
E
K
L
N
V
E
V
-
D
A
S
S
I
K
T
L
V
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
V
L
G
P
M
L
A
R
F
G
E
A
E
V
A
L
P
G
G
A
-
I
G
S
R
P
V
D
L
H
I
R
G
L
E
A
M
G
A
Q
I
E
V
E
G
G
Y
I
K
A
K
--
A
---
P
---
A
GG
L
R
G
G
H
F
F
F
D
--
T
V
S
V
T
G
T
E
N
L
M
M
A
A
A
L
A
N
G
R
T
V
L
Q
N
A
A
R
E
P
E
V
V
D
L
A
N
C
L
N
A
M
G
A
N
V
Q
G
A
G
S
D
T
I
V
I
E
G
V
K
R
L
G
G
A
R
Y
D
V
L
P
D
R
I
E
T
G
T
Y
L
V
A
A
A
A
T
G
G
R
V
K
L
K
D
T
D
P
T
I
L
E
A
V
L
Q
K
L
E
E
A
G
A
H
I
S
T
G
S
N
W
I
E
L
D
-
M
K
-
G
N
R
P
-
K
A
V
N
V
R
T
A
P
Y
P
A
F
P
T
D
M
Q
A
Q
F
I
S
M
N
A
V
A
E
G
T
G
A
V
I
E
T
V
F
E
N
R
F
M
H
V
Y
E
M
N
R
M
G
A
Q
I
L
V
E
G
N
T
A
I
V
T
G
V
P
K
L
K
G
A
P
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
C
I
E
E
K
L
Q
L
L
G
A
K
I
R
R
--------
23
PsiBlast_CBE
87.69
45%
-102
- C7 -
3VCY
4
MURA_VIBFM
C:
[2-416]
--
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
R
-
N
G
S
V
H
-
I
-
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
E
--
V
---
D
G--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
G
M
G
T
D
T
I
T
I
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
D
V
Q
T
G
D
D
W
I
S
L
D
-
M
T
G
R
E
-
L
-
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
--------
7
PsiBlast_PDB
87.36
45%
-104
- C7 -
3VCY
4
MURA_VIBFM
A:
[2-416]
--
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
R
-
N
G
S
V
H
-
I
-
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
E
--
V
---
D
G
--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
G
M
G
T
D
T
I
T
I
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
D
V
Q
T
G
D
D
W
I
S
L
D
-
M
T
G
R
E
-
L
-
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
--------
24
PsiBlast_CBE
87.35
45%
-104
- C7 -
3VCY
4
MURA_VIBFM
B:
[2-416]
--
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
R
-
N
G
S
V
H
-
I
-
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
E
--
V
---
D
G--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
G
M
G
T
D
T
I
T
I
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
D
V
Q
T
G
D
D
W
I
S
L
D
-
M
T
G
R
E
-
L
-
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
--------
22
PsiBlast_CBE
87.06
45%
-101
- C7 -
3VCY
4
MURA_VIBFM
D:
[2-416]
--
D
K
F
R
I
Q
G
S
D
K
P
L
S
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
L
L
A
-
E
E
P
V
E
V
A
N
V
P
K
L
R
D
V
D
T
T
M
E
L
L
K
R
L
G
A
E
V
S
R
-
N
G
S
V
H
-
I
-
D
A
S
G
V
N
D
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
K
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
E
--
V
---
D
G--
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
I
T
V
M
C
A
A
T
L
A
E
G
T
T
V
L
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
N
A
I
G
A
K
V
S
G
M
G
T
D
T
I
T
I
E
G
V
E
R
L
G
G
G
Y
H
E
V
V
A
D
R
I
E
T
G
T
F
L
V
A
A
A
V
S
G
G
K
I
V
C
K
N
T
K
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
D
V
Q
T
G
D
D
W
I
S
L
D
-
M
T
G
R
E
-
L
-
K
A
V
N
I
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
S
G
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
Q
R
M
G
A
H
A
E
I
E
G
N
T
A
I
C
G
D
T
D
G
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
D
K
I
E
D
K
L
T
A
L
G
A
N
I
E
R
--------
8
PsiBlast_PDB
86.71
44%
-103
- C7 -
1NAW
2
MURA_ENTCC
A:
[2-415]
--
D
K
F
R
V
Q
G
P
T
R
-
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
L
L
A
-
E
E
P
V
E
I
Q
N
V
P
K
L
K
D
I
D
T
T
M
K
L
L
T
Q
L
G
T
K
V
E
R
-
N
G
S
V
W
-
I
-
D
A
S
N
V
N
N
F
S
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
F
G
L
E
K
L
G
A
E
I
K
L
E
E
G
--
Y
V
K
--
A
---
S
V
N
G
R
--
L
K
G
A
H
I
V
M
D
--
K
V
S
V
G
A
T
V
T
I
M
S
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
V
A
L
G
A
K
I
S
G
Q
G
T
D
R
I
T
I
E
G
V
E
R
L
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
V
A
A
A
I
S
G
G
K
I
V
C
R
N
A
Q
P
D
T
L
D
A
V
L
A
K
L
R
E
A
G
A
D
I
E
T
G
E
D
W
I
S
L
D
M
H
G
-
K
R
-
P
-
K
A
V
T
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
I
R
M
G
A
H
A
E
I
E
S
N
T
V
I
C
H
G
V
E
K
L
S
G
A
Q
V
M
A
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
--------
14
PsiBlast_PDB
83.57
40%
-102
- C7 -
2YVW
2
MURA_AQUAE
A:
[11-423]
--
D
Y
F
V
I
R
G
G
K
P
-
L
T
G
K
V
K
I
S
G
A
K
N
A
A
L
P
I
M
F
A
T
I
L
T
-
E
E
P
C
T
I
T
N
V
P
D
L
L
D
V
R
N
T
L
L
L
L
R
E
L
G
A
E
L
E
F
L
N
N
T
V
F
-
I
-
N
P
S
-
I
N
S
F
I
T
N
Q
E
I
I
R
R
M
R
A
S
V
L
S
L
G
P
L
L
G
R
F
G
R
A
V
V
G
L
P
G
G
C
S
I
G
A
R
P
I
D
Q
H
L
K
F
F
K
E
A
G
A
D
V
E
V
R
E
G
Y
V
Y
V
N
--
L
---
K
---
E
--
K
R
R
V
H
F
K
F
D
--
L
V
T
V
T
G
T
E
N
A
L
L
Y
L
A
S
V
P
E
E
S
I
L
E
N
I
A
L
E
P
E
V
M
D
L
I
E
V
L
K
K
M
G
A
H
V
K
V
E
G
R
S
A
Y
-
V
K
G
S
E
N
L
K
G
F
T
H
S
V
I
P
D
R
I
E
A
G
T
F
M
V
G
A
V
L
T
D
G
E
I
L
L
E
N
A
R
I
N
H
L
R
A
V
V
E
K
L
K
L
I
G
G
E
V
V
E
E
N
G
N
L
R
V
F
-
R
K
-
E
S
-
L
-
R
A
C
D
I
E
T
Q
V
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
L
S
V
A
K
G
K
S
R
I
K
E
N
I
F
E
H
R
F
H
H
A
Q
E
L
N
R
L
G
A
N
I
T
V
R
G
N
T
A
Y
V
E
G
V
E
R
L
Y
G
S
E
V
Y
S
T
D
L
R
A
S
A
S
L
V
L
A
G
L
V
A
Q
G
E
T
V
V
R
D
V
Y
H
L
D
R
G
Y
E
K
L
E
E
K
L
K
K
L
G
A
D
I
E
R
V
S
------
54
HHSearch
82.81
40%
-98
- C7 -
2YVW
2
MURA_AQUAE
A:
[10-424]
-
R
D
Y
F
V
I
R
G
G
K
P
-
L
T
G
K
V
K
I
S
G
A
K
N
A
A
L
P
I
M
F
A
T
I
L
T
-
E
E
P
C
T
I
T
N
V
P
D
L
L
D
V
R
N
T
L
L
L
L
R
E
L
G
A
E
L
E
F
L
N
N
T
V
F
-
I
-
N
P
S
I
-
N
S
F
I
T
N
Q
E
I
I
R
R
M
R
A
S
V
L
S
L
G
P
L
L
G
R
F
G
R
A
V
V
G
L
P
G
G
C
S
I
G
A
R
P
I
D
Q
H
L
K
F
F
K
E
A
G
A
D
V
E
V
R
E
G
Y
V
Y
V
N
--
L
---
K
---
E
--
K
R
R
V
H
F
K
F
D
LV
T
V
T
G
T
E
N
-
A
L
L
Y
L
A
S
V
-
P
E
E
S
I
L
E
N
I
A
L
E
P
E
V
M
D
L
I
E
V
L
K
K
M
G
A
H
V
K
V
E
G
R
-
S
A
Y
V
K
G
S
E
N
L
K
G
F
T
H
S
V
I
P
D
R
I
E
A
G
T
F
M
V
G
A
V
L
T
D
G
E
I
L
L
E
N
A
R
I
N
H
L
R
A
V
V
E
K
L
K
L
I
G
G
E
V
V
E
E
N
G
N
L
R
V
F
-
R
K
-
E
S
-
L
-
R
A
C
D
I
E
T
Q
V
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
L
S
V
A
K
G
K
S
R
I
K
E
N
I
F
E
H
R
F
H
H
A
Q
E
L
N
R
L
G
A
N
I
T
V
R
G
N
T
A
Y
V
E
G
V
E
R
L
Y
G
S
E
V
Y
S
T
D
L
R
A
S
A
S
L
V
L
A
G
L
V
A
Q
G
E
T
V
V
R
D
V
Y
H
L
D
R
G
Y
E
K
L
E
E
K
L
K
K
L
G
A
D
I
E
R
V
S
E
-----