@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2754: (2016-04-07 )
VKNIIKKTGILIMAASLAVSGFLVSPKAAQAAEAPNVNANAAIAIEESTGKILYSKDADKLMGIASMTKMMDEYLLLEAIDKGKLKWDDKVTISEYAYKVSQDTSLSNVPLRLGEEYTVQELYEAMAIYSANGAAIAISEKIAGSEKEFVDAMNKKADELNLGEHQFVNATGLNNEDLKGGQQVGGPKDENKMTARGMAKLAKHLINDYPDVLKTASTTKKEFRKGTSDQIDMTNWNWLLPGLIYGRKGVDGLKTGTTDYAGMCLTATAVQDGMRVITVVLHANGGAPGEHTSARFDETNKMLDYAFNNFKVKEVQKAGSKVKNPSTIAVDKGKEDTVGLVTKDAVKLVVPKNGNAPKLNTKVTMKEKTIEAPVKKGTEVGKMEVSLKDGDKLGYVDGKQTETIDVLTASDVEKANWFMLSTQAVGSFFTGMGNYVSDGVKGWFN
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90.......----.100.--.--.....110.......120.......130.......140.......150.......160.......170.......180...-.-...-190.-......200.......210.......220...---....230.......240......-.250.......260.......-270........280.......290.......300.......310.......320.......330---.......340........350.......360.......370.......380.......390..--.....400.......410.......420.......430.......440...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
V
K
N
I
I
K
KT
G
I
L
I
M
A
A
S
L
AVS
G
F
LVSPKAAQAAEAPNVNA
N
A
A
I
A
I
EEST
G
K
I
L
YSK
D
A
D
K
L
M
G
I
A
S
M
T
K
M
M
D
E
Y
L
L
L
E
A
IDKGKLKWDDKV
T
I
S
E
Y
A
Y
----KVSQD--T--SLSNVPLRLGEE
Y
T
V
Q
E
L
Y
E
A
M
A
IYSAN
G
A
A
I
A
I
S
E
KIAG
S
E
K
E
F
V
D
A
M
NKKADELNLGE
H
Q
F
V
NATGLN
N
E
DLKGGQQVG-G-PKD-EN
K
M
-
T
A
R
G
M
A
K
L
A
K
H
L
I
N
D
Y
P
D
V
L
K
TAST
T
K
K
E
F
RK---GTSDQIDMTNW
N
W
L
L
P
G
L
I
YGRK-GVDGLKTGTTDYA
G
M
C
L
T
A
T
A
-
V
-QDG
M
R
V
I
T
V
V
L
HANGGAPGEHTSARFDET
N
K
M
L
D
Y
AFNN
F
K
V
K
E
V
Q
K
AGSKVKNP
S
T
I
A
VDK---GKED
T
V
G
L
-
V
TK
D
A
V
K
L
V
VPKNGNAPKLN
T
K
V
T
M
KEKTIEAPVKKGTEVG
K
M
E
V
S
LKDGDKLG--YVDGKQ
T
E
T
I
D
V
L
TASDVEKA
N
W
F
M
L
S
T
Q
A
V
G
S
F
F
T
G
M
G
N
Y
V
S
D
G
V
K
GWFN
1
PsiBlast_PDB
90.13
40%
-55
- C5 -
1XP4
5
?
A:
[12-362]
------------------------------------
I
A
A
K
H
A
I
A
V
E
A
N
T
G
K
I
L
Y
E
K
D
A
T
Q
P
V
E
I
A
S
I
T
K
L
I
T
V
Y
L
V
Y
E
A
L
E
N
G
S
I
T
L
S
T
P
V
D
I
S
D
Y
P
Y
----
Q
L
T
T
N
--
S
--
E
A
S
N
I
P
M
E
-
A
R
N
Y
T
V
E
E
L
L
E
A
T
L
V
S
S
A
N
S
A
A
I
A
L
A
E
K
I
A
G
S
E
K
D
F
V
D
M
M
R
A
K
L
L
E
W
G
I
Q
D
A
T
V
V
N
T
T
G
L
N
N
E
T
L
G
D
N
I
Y
P
G
-
S
-
K
K
D
E
E
N
K
L
-
S
A
Y
D
V
A
I
V
A
R
N
L
I
K
K
Y
P
Q
V
L
E
I
T
K
K
P
S
S
T
F
A
G
---
M
T
-----
I
T
S
T
N
Y
M
L
E
G
M
P
A
Y
R
G
-
G
F
D
G
L
K
T
G
T
T
D
K
A
G
E
S
F
V
G
T
T
-
V
-
E
K
G
M
R
V
I
T
V
V
L
N
A
D
H
Q
D
N
N
P
Y
--
A
R
F
T
A
T
S
S
L
M
D
Y
I
S
S
T
F
T
L
R
K
I
V
Q
Q
G
D
A
Y
Q
D
-
S
K
A
P
V
Q
D
---
G
K
E
D
T
V
I
A
-
V
A
P
E
D
I
Y
L
-
I
E
R
V
G
N
Q
S
S
Q
S
V
Q
F
T
P
D
S
K
A
I
P
A
P
L
E
A
G
T
V
V
G
H
L
T
Y
E
D
K
D
L
I
G
Q
G
--
Y
I
-------------------------------------------------
33
HHSearch
90.05
39%
-52
- C5 -
1XP4
5
?
A:
[10-378]
----------------------------------
F
T
I
A
A
K
H
A
I
A
V
E
A
N
T
G
K
I
L
Y
E
K
D
A
T
Q
P
V
E
I
A
S
I
T
K
L
I
T
V
Y
L
V
Y
E
A
L
E
N
G
S
I
T
L
S
T
P
V
D
I
S
D
Y
P
Y
----
Q
L
T
T
N
--
S
--
E
A
S
N
I
P
M
E
-
A
R
N
Y
T
V
E
E
L
L
E
A
T
L
V
S
S
A
N
S
A
A
I
A
L
A
E
K
I
A
G
S
E
K
D
F
V
D
M
M
R
A
K
L
L
E
W
G
I
Q
D
A
T
V
V
N
T
T
G
L
N
N
E
T
L
G
D
N
I
Y
P
G
S
K
-
K
D
E
-
E
N
K
L
-
S
A
Y
D
V
A
I
V
A
R
N
L
I
K
K
Y
P
Q
V
L
E
I
T
K
K
P
S
S
T
F
A
G
--------
M
T
I
T
S
T
N
Y
M
L
E
G
M
P
A
Y
R
G
-
G
F
D
G
L
K
T
G
T
T
D
K
A
G
E
S
F
V
G
T
T
-
V
-
E
K
G
M
R
V
I
T
V
V
L
N
A
D
H
Q
D
--
N
N
P
Y
A
R
F
T
A
T
S
S
L
M
D
Y
I
S
S
T
F
T
L
R
K
I
V
Q
Q
G
D
A
Y
Q
-
D
S
K
A
P
V
Q
D
---
G
K
E
D
T
V
I
A
-
V
A
P
E
D
I
Y
L
I
E
R
V
G
N
Q
S
S
Q
-
S
V
Q
F
T
P
D
S
K
A
I
P
A
P
L
E
A
G
T
V
V
G
H
L
T
Y
E
-
D
-
K
D
L
I
G
QG
Y
I
T
T
E
-
R
P
S
F
E
M
V
A
D
K
K
I
E
--------------------------------
22
PsiBlast_CBE
87.23
31%
-56
- C5 -
3ITB
3
DACC_ECOLI
D:
[2-350]
---------------------------
A
E
Q
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
24
PsiBlast_CBE
86.85
31%
-52
- C5 -
3ITB
3
DACC_ECOLI
B:
[7-350]
--------------------------------
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
29
PsiBlast_CBE
86.29
31%
-55
- C5 -
3IT9
4
DACC_ECOLI
B:
[8-350]
---------------------------------
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
4
PsiBlast_PDB
85.99
31%
-55
- C5 -
3ITA
3
DACC_ECOLI
A:
[5-350]
------------------------------
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
3
PsiBlast_PDB
85.90
31%
-52
- C5 -
3IT9
6
DACC_ECOLI
A:
[5-350]
------------------------------
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
28
PsiBlast_CBE
85.83
31%
-58
- C5 -
3IT9
3
DACC_ECOLI
C:
[7-350]
--------------------------------
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
------------
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
27
PsiBlast_CBE
85.60
31%
-51
- C5 -
3IT9
3
DACC_ECOLI
D:
[3-350]
----------------------------
E
Q
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
6
PsiBlast_PDB
85.37
29%
-63
- C5 -
3A3J
1
DACA_HAEIN
A:
[5-342]
----------------------------------
P
Q
I
T
A
Q
T
Y
V
L
M
D
Y
N
S
G
A
I
L
T
A
L
N
P
D
Q
R
Q
Y
P
A
S
L
T
K
M
M
T
S
Y
V
V
G
V
A
L
K
Q
G
K
I
H
N
T
D
M
V
T
I
G
E
S
A
W
----
G
R
N
F
P
--
D
--
S
-
S
K
M
F
L
D
L
N
T
Q
V
S
V
A
D
L
N
R
G
V
I
V
V
S
G
N
D
A
T
V
A
L
A
E
H
I
S
G
N
V
P
N
F
V
E
T
M
N
K
Y
V
Q
Q
F
G
L
K
N
T
N
F
T
T
P
H
G
L
D
----------------
D
-
P
N
Q
Y
S
S
A
R
D
M
A
I
I
G
A
H
I
I
R
D
L
P
E
E
Y
K
I
Y
S
--
E
K
D
F
------
T
F
N
K
I
K
Q
P
N
R
N
----
G
L
L
W
D
K
T
I
N
V
D
G
M
K
T
G
H
T
S
Q
A
G
Y
N
L
V
A
S
A
T
T
-
S
N
N
M
R
L
I
S
V
V
M
----
G
V
P
T
--
Y
K
G
R
E
V
E
S
K
K
L
L
Q
W
G
F
A
N
F
E
T
F
K
T
L
E
A
G
K
E
I
---
S
E
Q
R
V
Y
Y
---
G
D
K
N
S
V
K
L
-
G
A
F
M
D
H
F
I
T
I
P
K
-
G
K
Q
S
E
V
K
A
R
Y
E
L
A
D
K
N
L
Q
A
P
L
A
K
G
Q
V
I
G
K
V
V
Y
A
L
-----------
D
G
K
D
I
A
S
A
N
L
Q
V
M
N
D
V
---------------------------------
31
HHSearch
85.24
33%
-52
- C5 -
3ITA
3
DACC_ECOLI
A:
[5-352]
------------------------------
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
AL
R
--
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
G
----------------
Q
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
---
I
-----
R
Q
P
N
R
N
R
L
L
W
S
---
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
K
T
------
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
---
V
T
Q
R
V
W
F
---
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
G
Q
L
K
N
L
-
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
-
L
N
G
K
S
----------
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
G
-----------------------------
5
PsiBlast_PDB
84.61
31%
-52
- C5 -
3ITB
4
DACC_ECOLI
A:
[5-350]
------------------------------
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
---
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
26
PsiBlast_CBE
84.57
31%
-50
- C5 -
3ITA
4
DACC_ECOLI
B:
[6-350]
-------------------------------
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
23
PsiBlast_CBE
84.28
31%
-53
- C5 -
3ITB
3
DACC_ECOLI
C:
[6-350]
-------------------------------
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
----
A
T
G
N
P
--
A
LR
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
12
PsiBlast_PDB
83.19
30%
-55
- C5 -
3MZD
2
DACA_ECOLI
A:
[13-357]
----------------------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
I
G
N
D
A
W
ATGN
P
V
F
K
G
--
S
--
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
T
H
F
---
Q
T
V
H
-
G
L
D
A
D
-
G
Q
Y
S
-
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
--
E
Y
S
I
Y
K
E
K
E
F
------
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
-
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
------
G
R
T
F
K
G
R
E
A
E
S
K
K
L
L
T
W
G
F
R
F
F
E
T
V
N
P
L
K
V
G
---
K
E
F
A
S
E
P
V
W
F
---
G
D
S
D
R
A
S
L
-
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
L
N
S
S
E
L
H
A
P
L
Q
K
N
Q
V
V
G
T
I
N
F
Q
L
-----------
D
G
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
F
----------------------------
25
PsiBlast_CBE
83.10
31%
-54
- C5 -
3ITA
3
DACC_ECOLI
D:
[3-350]
----------------------------
E
Q
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
-----------------------
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
P
----
G
Q
------------
F
S
-
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
--
E
Y
A
I
H
K
E
K
E
F
------
T
F
N
K
I
R
Q
P
N
R
N
R
L
---
L
W
S
S
N
L
-
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
-
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
------
K
T
D
R
I
R
F
N
E
S
E
K
L
L
T
W
G
F
R
F
F
E
T
V
------
T
P
I
K
P
D
A
T
F
V
T
Q
R
V
W
F
G
D
K
S
E
V
N
L
-
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
L
T
E
P
Q
L
T
A
P
L
K
K
G
Q
V
V
G
T
I
D
F
Q
L
-----------
N
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
-------------------------------
14
PsiBlast_PDB
82.74
30%
-56
- C5 -
3MZF
2
DACA_ECOLI
A:
[13-357]
----------------------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
I
G
N
D
A
W
ATGN
P
V
F
K
G
--
S
--
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
T
H
F
---
Q
T
V
H
-
G
L
D
A
D
-
G
Q
Y
S
-
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
--
E
Y
S
I
Y
K
E
K
E
F
------
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
-
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
------
G
R
T
F
K
G
R
E
A
E
S
K
K
L
L
T
W
G
F
R
F
F
E
T
V
N
P
L
K
V
G
---
K
E
F
A
S
E
P
V
W
F
---
G
D
S
D
R
A
S
L
-
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
L
N
S
S
E
L
H
A
P
L
Q
K
N
Q
V
V
G
T
I
N
F
Q
L
-----------
D
G
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
F
----------------------------
32
HHSearch
82.68
30%
-55
- C5 -
3A3J
1
DACA_HAEIN
A:
[3-344]
--------------------------------
T
P
P
Q
I
T
A
Q
T
Y
V
L
M
D
Y
N
S
G
A
I
L
T
A
L
N
P
D
Q
R
Q
Y
P
A
S
L
T
K
M
M
T
S
Y
V
V
G
V
A
L
K
Q
G
K
I
H
N
T
D
M
V
T
I
G
E
S
A
W
----
G
R
N
-
F
--
P
--
D
S
S
K
M
F
L
D
L
N
T
Q
V
S
V
A
D
L
N
R
G
V
I
V
V
S
G
N
D
A
T
V
A
L
A
E
H
I
S
G
N
V
P
N
F
V
E
T
M
N
K
Y
V
Q
Q
F
G
L
K
N
T
N
F
T
T
P
H
G
L
D
D
P
N
----------------
Q
Y
S
-
S
A
R
D
M
A
I
I
G
A
H
I
I
R
D
L
P
E
E
Y
K
I
Y
S
E
K
D
F
T
F
N
K
--------
I
K
Q
P
N
R
N
G
L
L
W
D
K
---
T
I
-
N
V
D
G
M
K
T
G
H
T
S
Q
A
G
Y
N
L
V
A
S
A
-
T
T
S
N
N
M
R
L
I
S
V
V
M
G
V
P
T
------
Y
K
G
R
E
V
E
S
K
K
L
L
Q
W
G
F
A
N
F
E
T
F
K
T
L
E
A
G
K
E
I
---
S
E
Q
R
V
Y
Y
---
G
D
K
N
S
V
K
L
-
G
A
F
M
D
H
F
I
T
I
P
K
G
K
Q
S
E
V
-
K
A
R
Y
E
L
A
D
K
N
L
Q
A
P
L
A
K
G
Q
V
I
G
K
V
V
Y
A
-
L
D
G
K
D
----------
I
A
S
A
N
L
Q
V
M
N
D
V
G
E
-------------------------------
9
PsiBlast_PDB
82.48
30%
-55
- C5 -
1Z6F
2
DACA_ECOLI
A:
[13-357]
----------------------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
I
G
N
D
A
W
ATGN
P
V
F
K
G
--
S
--
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
T
H
F
---
Q
T
V
H
-
G
L
D
A
D
-
G
Q
Y
S
-
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
--
E
Y
S
I
Y
K
E
K
E
F
------
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
-
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
------
G
R
T
F
K
G
R
E
A
E
S
K
K
L
L
T
W
G
F
R
F
F
E
T
V
N
P
L
K
V
G
---
K
E
F
A
S
E
P
V
W
F
---
G
D
S
D
R
A
S
L
-
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
L
N
S
S
E
L
H
A
P
L
Q
K
N
Q
V
V
G
T
I
N
F
Q
L
-----------
D
G
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
F
----------------------------
10
PsiBlast_PDB
82.42
30%
-57
- C5 -
3BEB
2
DACA_ECOLI
A:
[13-357]
----------------------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
I
G
N
D
A
W
ATGN
P
V
F
K
G
--
S
--
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
T
H
F
---
Q
T
V
H
-
G
L
D
A
D
-
G
Q
Y
S
-
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
--
E
Y
S
I
Y
K
E
K
E
F
------
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
-
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
------
G
R
T
F
K
G
R
E
A
E
S
K
K
L
L
T
W
G
F
R
F
F
E
T
V
N
P
L
K
V
G
---
K
E
F
A
S
E
P
V
W
F
---
G
D
S
D
R
A
S
L
-
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
L
N
S
S
E
L
H
A
P
L
Q
K
N
Q
V
V
G
T
I
N
F
Q
L
-----------
D
G
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
F
----------------------------
11
PsiBlast_PDB
80.57
30%
-55
- C5 -
3BEC
5
DACA_ECOLI
A:
[13-355]
----------------------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
I
G
N
D
A
W
ATGN
P
V
F
K
G
--
S
--
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
T
H
F
---
Q
T
V
H
-
G
L
D
A
D
-
G
Q
Y
S
-
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
--
E
Y
S
I
Y
K
E
K
E
F
------
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
-
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
------
G
R
T
F
K
G
R
E
A
E
S
K
K
L
L
T
W
G
F
R
F
F
E
T
V
N
P
L
K
V
G
---
K
E
F
A
S
E
P
V
W
F
---
G
D
S
D
R
A
S
L
-
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
L
N
S
S
E
L
H
A
P
L
Q
K
N
Q
V
V
G
T
I
N
F
Q
L
-----------
D
G
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
------------------------------
21
PsiBlast_CBE
78.30
33%
-58
- C5 -
4K91
2
?
B:
[10-327]
----------------------------------
P
Q
L
A
A
K
S
Y
V
L
M
D
G
E
S
G
Q
V
L
V
E
N
N
G
D
Q
R
L
P
P
A
S
L
T
K
L
M
T
A
Y
I
A
T
K
E
I
E
A
G
R
I
G
E
N
D
L
V
T
V
S
E
H
A
W
----
R
------
T
--
G
G
S
R
M
F
I
K
V
G
S
Q
V
S
V
S
D
L
L
H
G
I
I
I
Q
S
G
N
D
A
S
V
A
L
A
E
H
I
A
G
S
E
D
A
F
A
D
M
M
N
T
T
A
Q
K
L
G
L
T
N
S
H
F
M
D
A
T
G
L
P
N
P
D
----------------
H
Y
S
-
S
A
R
D
M
A
V
L
A
R
A
I
I
Y
G
E
P
S
--
H
Y
A
I
Y
A
Q
K
E
F
------
L
W
N
N
I
K
Q
P
N
R
N
L
L
L
----
W
R
D
K
-
T
V
D
G
L
K
T
G
H
T
D
E
A
G
Y
C
L
V
A
S
A
-
V
-
R
D
G
Q
R
M
I
A
V
V
F
G
T
N
S
------
E
Q
A
R
A
A
E
T
Q
K
L
L
T
Y
G
F
R
F
F
E
S
R
N
F
Y
K
K
G
T
E
L
T
K
G
---
L
V
W
K
---
G
S
E
H
E
V
K
A
-
G
L
A
E
D
L
T
M
T
L
P
R
-
G
Q
M
Q
K
L
Q
A
S
M
V
L
-
E
P
Q
L
M
A
P
I
Q
Q
G
Q
V
I
G
K
V
E
V
K
L
D
D
----------------------------------------------------------
20
PsiBlast_PDB
69.10
30%
-48
- C5 -
1TVF
4
?
A:
[44-342]
------------------------------------------------
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
M
T
N
K
E
Y
----
I
M
S
T
L
--
P
--
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
S
R
L
R
S
F
A
P
T
K
-
Y
-
K
D
Q
-
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
--------
D
F
T
K
QL
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
A
K
M
S
L
P
-
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
-
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
G
D
Y
K
N
L
G
G
E
K
Q
R
N
M
M
G
N
A
L
M
E
R
S
F
D
Q
Y
K
Y
V
K
I
L
S
K
G
E
Q
R
I
N
G
K
K
Y
Y
V
E
N
---
D
L
Y
D
V
L
P
S
D
F
S
K
K
D
Y
K
L
V
V
-------------------------------------------------------------------------------------------------