@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2758: (2016-04-07 )
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQQAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKENLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKLIEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHGSKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITKEAPNYSIS
Atome Classification :
(46 SA)
.........10........20.....--...30......-------..40........50........60........70........80........--90........100.......110.......120.......130........140......-.150......-.-160.......170.......180.....--..190.......200.......210...-...-----.220.......230.......240.......250.......260.......270-.......280.......290.......300.......310.......320.......330.------......340.......350.......360.......370.......380.......390.......400.--------...-..--.---410.......420.......430.......440.......450....-----...460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MWETKFAKEGLTFD
D
V
L
L
VPAKSDVL--PNDV
D
L
S
V
E
MA-------PS
L
K
L
N
V
P
I
WSA
G
M
D
T
I
T
E
A
K
M
A
I
A
I
ARQG
G
I
G
V
V
HKNM
S
I
E
Q
Q
A
E
E
I
E
K
V
K--RSES
G
V
I
I
D
P
F
Y
LTPD
H
Q
V
F
A
A
E
H
L
MGKYRISGVPIVNNEKE-
R
K
L
V
G
I
LTNRD
L
R
F
I
S
D
-
Y
S
T
V
I
K
D
V
MT-K-ENLVTAPVG
T
T
L
K
Q
A
E
Q
I
L
Q
KHRIEKLP--LV
D
E
A
G
I
L
K
G
L
I
T
I
K
D
I
E
K
V
IEFPNSAK-DKH-----
G
R
L
L
A
A
A
AVGITN
D
T
F
V
R
V
E
K
L
I
E
AGV
D
A
I
V
I
DTAHGHSA
G
V
I
N
K
I
S
E
I
R
Q
T
F
K-D
V
V
I
V
AGNVA
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
VGIGPG
S
I
C
T
T
R
V
V
AGVGVP
Q
I
T
A
I
Y
D
C
A
T
V
A
R
E
------FGK
T
I
IADGG
I
K
YS
G
D
I
V
K
A
L
AAGG
N
A
V
M
L
GSMLAGTDESPGETEIFQGRQFKTYRGM
G
S
L
A
A
M
EHGSKD--------RY
F
-
Q
A
--
D
---
A
K
K
LVPEGIEGRVPYKG
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
SGMGYTGS
P
D
L
R
H
L
R
E
-----EA
A
F
V
R
MTGAGLRESHPH
D
I
Q
I
TKEAPNYSIS
1
PsiBlast_PDB
89.82
73%
-95
- C2 -
3TSB
2
?
A:
[25-510]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
E
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
--
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
-----
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G
S
K
D
--------
R
Y
F
-
Q
E
--
G
---
N
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
--
114
HHSearch
89.16
73%
-116
- C- -
1ZFJ
1
IMDH_STRPY
A:
[2-491]
N
W
D
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
N
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
-
Y
N
A
P
I
S
E
H
M
T
-
S
-
E
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
--
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
-----
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
-------------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-
4
PsiBlast_PDB
88.06
70%
-116
- C- -
1ZFJ
1
IMDH_STRPY
A:
[3-491]
-
W
D
T
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
N
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
-
Y
N
A
P
I
S
E
H
M
T
-
S
-
E
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
--
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
-----
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
-------------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-
113
HHSearch
84.93
74%
-105
- C2 -
3USB
4
?
A:
[25-493]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
E
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
--
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
-----
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
2
PsiBlast_PDB
84.86
73%
-101
- C2 -
3TSD
1
?
A:
[25-497]
M
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
E
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
--
K
-
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
--
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
-----
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
---------------
3
PsiBlast_PDB
83.96
71%
-105
- C2 -
3USB
4
?
A:
[26-493]
-
W
E
S
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
N
L
D
E
-
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
-
Y
S
I
K
I
S
D
V
M
T
-
K
-
E
Q
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
--
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
-----
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
6
PsiBlast_PDB
81.07
53%
-99
- C2 -
4FXS
3
?
A:
[5-486]
----
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
T
-------
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
E
N
N
E
---
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
-
L
T
K
S
V
A
A
V
M
T
P
K
-
E
R
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
--
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
S
S
D
--------
R
Y
F
-
Q
T
------
A
D
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
9
PsiBlast_PDB
76.80
54%
-104
- C2 -
4DQW
7
?
A:
[23-486]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
---
E
Q
-
G
E
L
V
G
I
V
T
G
R
D
L
R
V
K
P
N
-
A
G
D
T
V
A
A
I
M
T
P
K
-
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
--
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
-----------------------
21
PsiBlast_CBE
74.50
54%
-107
- C2 -
4DQW
5
?
B:
[23-486]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
---
E
Q
-
G
E
L
V
G
I
V
T
G
R
D
L
R
V
------
D
T
V
A
A
I
M
T
P
K
-
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
--
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
-----------------------
11
PsiBlast_PDB
68.82
49%
-94
- C2 -
2CU0
1
IMDH_PYRHO
A:
[11-480]
------
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
-----
G
E
L
L
V
A
A
A
V
S
P
F
D
--
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
------------------YM
K
---
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
115
HHSearch
68.41
50%
-92
- C2 -
2CU0
1
IMDH_PYRHO
A:
[10-480]
-----
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
--------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
-----
G
E
L
L
V
A
--
A
A
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
---------------------YMK
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
80
PsiBlast_CBE
68.15
39%
-91
- C2 -
1JR1
3
IMDH2_CRIGR
A:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
----
D
R
V
R
--
F
E
A
K
---------------
M
G
S
R
L
V
---------------------
I
M
T
-
K
R
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
---
K
L
P
--
I
V
N
E
N
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
76
PsiBlast_CBE
67.85
39%
-91
- C2 -
1NF7
3
IMDH2_HUMAN
A:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
-------------------------------
G
I
I
S
S
R
D
I
D
F
L
--E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
--
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
75
PsiBlast_CBE
67.84
39%
-91
- C2 -
1NF7
2
IMDH2_HUMAN
B:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
-------------------------------
G
I
I
S
S
R
D
I
D
F
L
--E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
--
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
117
HHSearch
66.63
59%
-95
- C2 -
1VRD
-
?
A:
[1-457]
------
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
K
--
K
T
----------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
-
D
E
K
-----
G
R
L
L
V
G
A
A
V
G
T
S
P
E
T
M
E
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
---------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
-----
K
A
V
F
V
K
I
T
------------------------
74
PsiBlast_CBE
66.41
39%
-98
- C2 -
1NFB
2
IMDH2_HUMAN
A:
[28-498]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
--
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
K
F
E
K
R
T
S
S
A
Q
--------------------
5
PsiBlast_PDB
66.34
58%
-95
- C2 -
1VRD
-
?
A:
[2-457]
-------
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
K
--
K
T
----------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
-
D
E
K
-----
G
R
L
L
V
G
A
A
V
G
T
S
P
E
T
M
E
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
---------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
-----
K
A
V
F
V
K
I
T
------------------------
8
PsiBlast_PDB
66.33
54%
-98
- C2 -
4AVF
-
?
A:
[3-467]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
--------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
------------------------------------------------
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
----------------------
73
PsiBlast_CBE
66.11
39%
-96
- C2 -
1NFB
2
IMDH2_HUMAN
B:
[28-498]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
T
G
R
M
G
S
-----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
--
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
K
F
E
K
R
T
S
S
A
Q
--------------------
119
HHSearch
65.52
52%
-100
- C2 -
1EEP
1
IMDH_BORBU
A:
[4-390]
----
K
I
T
K
E
A
L
T
F
D
D
V
S
L
I
P
R
K
S
S
V
L
--
P
S
E
V
S
L
K
T
Q
L
T
-------
K
N
I
S
L
N
I
P
F
L
S
S
A
M
D
T
V
T
E
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
H
K
N
M
S
I
E
A
Q
R
K
E
I
E
K
V
K
--
T
Y
K
--------------------------------------------------------------------------------------------------------------------------
D
F
P
N
A
C
K
-
D
L
N
-----
N
K
L
R
V
G
A
A
V
S
I
D
I
D
T
I
E
R
V
E
E
L
V
K
A
H
V
D
I
L
V
I
D
S
A
H
G
H
S
T
R
I
I
E
L
I
K
K
I
K
T
K
Y
P
-
N
L
D
L
I
A
G
N
I
V
T
K
E
A
A
L
D
L
I
S
V
G
A
D
C
L
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
I
C
D
V
Y
E
A
C
N
N
------
T
N
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
A
G
A
D
S
V
M
I
G
N
L
F
A
G
T
K
E
S
P
S
E
E
I
I
Y
N
G
K
K
F
K
S
-----------------------------------------------
M
V
P
Y
S
G
K
L
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
A
T
I
S
D
L
K
I
-----
N
S
K
F
V
K
I
S
H
S
----------------------
10
PsiBlast_PDB
64.94
54%
-104
- C2 -
5AHN
2
?
A:
[3-467]
----
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
---------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
----------------------
79
PsiBlast_CBE
64.28
39%
-91
- C2 -
1JR1
3
IMDH2_CRIGR
B:
[28-507]
--------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
--------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
-
D
A
K
-----
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
-
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
-----------
116
HHSearch
62.67
31%
-84
- C2 -
1ME8
3
IMDH_TRIFO
A:
[5-492]
-----
Y
N
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
CI
P
S
N
V
N
L
S
T
P
L
V
K
F
Q
KGQQ
S
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
-----------------------------------------------------------------------------------------------------------------------------
H
N
E
L
V
-
D
S
Q
-----
K
R
Y
L
V
G
A
G
I
N
T
-
R
D
F
R
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
E
G
S
S
R
A
R
N
W
------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
-----------
84
PsiBlast_CBE
62.08
40%
-95
- C2 -
4AF0
2
?
B:
[59-509]
---------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
--------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
-----
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
H
T
---GLDNAATA
R
Y
F
S
E
A
--
D
---
A
V
K
-
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
--------------------------------------------------
83
PsiBlast_CBE
61.92
40%
-94
- C2 -
4AF0
2
?
A:
[59-509]
---------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
--------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
-----
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
H
T
---GLDNAATA
R
Y
F
S
E
A
--
D
---
A
V
K
-
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
--------------------------------------------------
26
PsiBlast_CBE
61.44
70%
-105
- C2 -
4QM1
3
?
B:
[114-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
--------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
--
34
PsiBlast_CBE
61.43
70%
-106
- C2 -
4MYA
3
?
B:
[114-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
--------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
15
PsiBlast_PDB
60.97
70%
-101
- C2 -
4MYA
4
?
A:
[114-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
-------------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
19
PsiBlast_PDB
60.82
51%
-71
- C2 -
4FO4
3
?
A:
[14-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
---------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
60
PsiBlast_CBE
60.24
51%
-66
- C2 -
4FO4
3
?
B:
[14-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
IA
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
QVKIS
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
---------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
52
PsiBlast_CBE
60.19
51%
-66
- C2 -
4X3Z
3
?
B:
[14-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
---------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
53
PsiBlast_CBE
60.17
51%
-67
- C2 -
4X3Z
4
?
A:
[14-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
56
PsiBlast_CBE
59.72
51%
-65
- C2 -
4QNE
3
?
A:
[14-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
13
PsiBlast_PDB
59.65
70%
-103
- C2 -
4MY8
9
?
A:
[114-367]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G
S
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
------------------
44
PsiBlast_CBE
59.62
70%
-104
- C2 -
4MY8
7
?
B:
[114-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
---------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
55
PsiBlast_CBE
59.57
51%
-64
- C2 -
4QNE
3
?
B:
[14-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
IA
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
QVKIS
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
43
PsiBlast_CBE
59.34
70%
-108
- C2 -
4MY8
4
?
C:
[114-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
--------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
24
PsiBlast_CBE
58.76
70%
-101
- C2 -
4QM1
3
?
D:
[114-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
----------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
---------
58
PsiBlast_CBE
58.71
51%
-72
- C2 -
4IX2
3
?
C:
[14-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
IA
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
QVKIS
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
18
PsiBlast_PDB
58.68
70%
-104
- C2 -
4QM1
3
?
A:
[114-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
----------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
---------
57
PsiBlast_CBE
58.49
51%
-73
- C2 -
4IX2
3
?
D:
[14-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
IA
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
QVKIS
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
20
PsiBlast_PDB
58.48
51%
-68
- C2 -
4IX2
2
?
A:
[14-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
25
PsiBlast_CBE
58.21
70%
-103
- C2 -
4QM1
3
?
C:
[114-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
----------
59
PsiBlast_CBE
58.09
51%
-66
- C2 -
4IX2
2
?
B:
[14-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
81
PsiBlast_CBE
57.82
60%
-93
- C2 -
5AHM
3
?
A:
[110-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
-----
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
---------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
54
PsiBlast_CBE
56.46
51%
-74
- C2 -
4QQ3
3
?
A:
[14-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
D
D
V
L
L
V
P
A
-
H
S
T
V
L
P
N
T
A
D
-
L
-
R
T
R
L
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
--
G
F
I
-----
H
K
N
M
S
I
E
Q
Q
A
A
-
Q
V
H
Q
V
K
I
S
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
----------------------