@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2791: (2016-04-07 )
LSKVIALANQKGGVGKTTSSVNLSSSLAFLGKKVLLVDIDPQGNASSGVGVNKGEIEHCIYDVLVDDVAIQDVLQKTDLDNLNVIPATIQLAGAEVELVPAISREIRLKKAIDSIRDDYDYVIIDCPPSLGLLTLNALTAADSVLIPVQCEYYALEGLSQLLNTIRIVQKHLNEDLQIEGVLLTMLDARTNLGIQVIEEVKKYFQNKVFNTIIPRNVRLSEAPSHGKPILLYDAKSKGAEVYLELAKEVVAHG
Atome Classification :
(21 SA)
--------------------.........10........20........--30........40.-.-.......50.--------.-----.--.--.-----...60.---.......70......-...80.........90.....--...--100-........110....-.--.-.120.......130.......140.......150.......160.......170-.--.....--..180....-.-..190.-.--..-..-.200..--.....210.......220.......230.......240.......250.--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------LS
K
V
I
A
LANQKGGVGKTTSSVN
L
S
S
S
L
A
F
--LG
K
K
V
L
L
V
D
ID-P-Q-GNASSGVGV
N
--------
K
-----
G
--
E
--
I
-----
E
H
C
I
Y
D
---
V
L
V
D
D
V
A
I
-
Q
D
V
L
Q
K-TDLD-NLNVI
P
A
T
I
Q
LAG
A
E
V
--
E
L
V
--PA--
I
S
R
E
I
R
L
K
K
A
I
D
S
IR-D--D-Y
D
Y
V
I
I
DCPPSL
G
L
L
T
L
NALTAAD
S
V
L
I
P
V
Q
C
E
Y
Y
A
L
E
G
L
S
Q
L
L
N
T
I
R
I
V
Q
K
H--L--NED
L
Q
--
I
E
G
V
L
L
T
M
L
-D-ARTNL
G
-
I
--
Q
V
-
I
E
-
E
V
K
K
Y
F
--
Q
N
K
V
F
N
T
IIPRNVRLSEAPSHGK
P
I
L
L
Y
DAKSK
G
A
E
V
Y
L
E
L
A
K
E
V
VAHG--------
21
PsiBlast_CBE
95.20
49%
-108
- C1 -
2BEK
3
SOJ_THET2
D:
[7-245]
----------------------
R
R
I
A
L
A
N
Q
K
G
G
V
G
K
T
T
T
A
I
N
L
A
A
Y
L
A
R
--
L
G
K
R
V
L
L
V
D
L
A
-
P
-
Q
-
G
N
A
T
S
G
L
G
V
R
--------
A
-----------------
E
R
G
V
Y
H
---
L
L
Q
G
E
-
P
L
-
E
G
L
V
H
P
---
V
D
-
G
F
H
L
L
P
A
T
P
D
L
V
G
A
T
V
--
E
L
A
GA
P
T
--
A
L
R
E
--------
A
L
R
-
D
--
E
G
Y
D
L
V
L
L
D
A
P
P
S
L
S
P
L
T
L
N
A
L
A
A
A
E
G
V
V
V
P
V
Q
A
E
Y
Y
A
L
E
G
V
A
G
L
L
A
T
L
E
E
V
R
A
G
--
L
--
N
P
R
L
R
--
L
L
G
I
L
V
T
M
Y
-
D
-
G
R
T
L
L
A
-
Q
--
Q
V
-
E
A
-
Q
L
R
A
H
F
--
G
E
K
V
F
W
T
V
I
P
R
N
V
R
L
A
E
A
P
S
F
G
K
T
I
A
Q
H
A
P
T
S
P
G
A
H
A
Y
R
R
L
A
E
E
V
M
A
R
---------
22
PsiBlast_CBE
95.09
49%
-112
- C1 -
2BEK
3
SOJ_THET2
C:
[7-245]
----------------------
R
R
I
A
L
A
N
Q
K
G
G
V
G
K
T
T
T
A
I
N
L
A
A
Y
L
A
R
--
L
G
K
R
V
L
L
V
D
L
A
-
P
-
Q
-
G
N
A
T
S
G
L
G
V
R
--------
A
-----------------
E
R
G
V
Y
H
---
L
L
Q
G
E
-
P
L
-
E
G
L
V
H
P
---
V
D
-
G
F
H
L
L
P
A
T
P
D
L
V
G
A
T
V
--
E
L
A
GA
P
T
--
A
L
R
E
--------
A
L
R
-
D
--
E
G
Y
D
L
V
L
L
D
A
P
P
S
L
S
P
L
T
L
N
A
L
A
A
A
E
G
V
V
V
P
V
Q
A
E
Y
Y
A
L
E
G
V
A
G
L
L
A
T
L
E
E
V
R
A
G
--
L
--
N
P
R
L
R
--
L
L
G
I
L
V
T
M
Y
-
D
-
G
R
T
L
L
A
-
Q
--
Q
V
-
E
A
-
Q
L
R
A
H
F
--
G
E
K
V
F
W
T
V
I
P
R
N
V
R
L
A
E
A
P
S
F
G
K
T
I
A
Q
H
A
P
T
S
P
G
A
H
A
Y
R
R
L
A
E
E
V
M
A
R
---------
23
PsiBlast_CBE
94.80
49%
-108
- C1 -
2BEK
3
SOJ_THET2
B:
[7-245]
----------------------
R
R
I
A
L
A
N
Q
K
G
G
V
G
K
T
T
T
A
I
N
L
A
A
Y
L
A
R
--
L
G
K
R
V
L
L
V
D
L
A
-
P
-
Q
-
G
N
A
T
S
G
L
G
V
R
--------
A
-----------------
E
R
G
V
Y
H
---
L
L
Q
G
E
-
P
L
-
E
G
L
V
H
P
---
V
D
-
G
F
H
L
L
P
A
T
P
D
L
V
G
A
T
V
--
E
L
A
GA
P
T
--
A
L
R
E
--------
A
L
R
-
D
--
E
G
Y
D
L
V
L
L
D
A
P
P
S
L
S
P
L
T
L
N
A
L
A
A
A
E
G
V
V
V
P
V
Q
A
E
Y
Y
A
L
E
G
V
A
G
L
L
A
T
L
E
E
V
R
A
G
--
L
--
N
P
R
L
R
--
L
L
G
I
L
V
T
M
Y
-
D
-
G
R
T
L
L
A
-
Q
--
Q
V
-
E
A
-
Q
L
R
A
H
F
--
G
E
K
V
F
W
T
V
I
P
R
N
V
R
L
A
E
A
P
S
F
G
K
T
I
A
Q
H
A
P
T
S
P
G
A
H
A
Y
R
R
L
A
E
E
V
M
A
R
---------
2
PsiBlast_PDB
94.70
49%
-109
- C1 -
2BEK
3
SOJ_THET2
A:
[7-245]
----------------------
R
R
I
A
L
A
N
Q
K
G
G
V
G
K
T
T
T
A
I
N
L
A
A
Y
L
A
R
--
L
G
K
R
V
L
L
V
D
L
A
-
P
-
Q
-
G
N
A
T
S
G
L
G
V
R
--------
A
-----------------
E
R
G
V
Y
H
---
L
L
Q
G
E
-
P
L
-
E
G
L
V
H
P
---
V
D
-
G
F
H
L
L
P
A
T
P
D
L
V
G
A
T
V
--
E
L
A
GA
P
T
--
A
L
R
E
--------
A
L
R
-
D
--
E
G
Y
D
L
V
L
L
D
A
P
P
S
L
S
P
L
T
L
N
A
L
A
A
A
E
G
V
V
V
P
V
Q
A
E
Y
Y
A
L
E
G
V
A
G
L
L
A
T
L
E
E
V
R
A
G
--
L
--
N
P
R
L
R
--
L
L
G
I
L
V
T
M
Y
-
D
-
G
R
T
L
L
A
-
Q
--
Q
V
-
E
A
-
Q
L
R
A
H
F
--
G
E
K
V
F
W
T
V
I
P
R
N
V
R
L
A
E
A
P
S
F
G
K
T
I
A
Q
H
A
P
T
S
P
G
A
H
A
Y
R
R
L
A
E
E
V
M
A
R
---------
1
PsiBlast_PDB
94.59
49%
-105
* C1 *
2BEJ
2
SOJ_THET2
A:
[7-245]
----------------------
R
R
I
A
L
A
N
Q
K
G
G
V
G
K
T
T
T
A
I
N
L
A
A
Y
L
A
R
--
L
G
K
R
V
L
L
V
D
L
D
-
P
-
Q
-
G
N
A
T
S
G
L
G
V
R
--------
A
-----------------
E
R
G
V
Y
H
---
L
L
Q
G
E
-
P
L
-
E
G
L
V
H
P
---
V
D
-
G
F
H
L
L
P
A
T
P
D
L
V
G
A
T
V
--
E
L
A
GA
P
T
--
A
L
R
E
--------
A
L
R
-
D
--
E
G
Y
D
L
V
L
L
D
A
P
P
S
L
S
P
L
T
L
N
A
L
A
A
A
E
G
V
V
V
P
V
Q
A
E
Y
Y
A
L
E
G
V
A
G
L
L
A
T
L
E
E
V
R
A
G
--
L
--
N
P
R
L
R
--
L
L
G
I
L
V
T
M
Y
-
D
-
G
R
T
L
L
A
-
Q
--
Q
V
-
E
A
-
Q
L
R
A
H
F
--
G
E
K
V
F
W
T
V
I
P
R
N
V
R
L
A
E
A
P
S
F
G
K
T
I
A
Q
H
A
P
T
S
P
G
A
H
A
Y
R
R
L
A
E
E
V
M
A
R
---------
3
PsiBlast_PDB
91.76
42%
-112
- C1 -
4PFS
-
?
A:
[9-258]
--------------------
M
T
R
V
L
A
V
A
N
Q
K
G
--
A
K
T
T
T
V
A
S
I
G
A
A
L
T
E
--
Q
G
R
R
V
L
L
V
D
L
D
-
P
-
Q
-
G
C
L
T
F
S
L
G
H
D
--------
P
-----
D
--
K
--
L
-----
P
V
S
V
H
E
---
V
L
L
G
D
V
E
P
-
S
A
A
L
V
R
-
T
D
-
E
-
G
M
T
L
L
P
A
N
I
D
L
A
G
A
E
A
--
M
L
L
--
M
R
--
A
G
R
E
Y
A
L
K
R
A
L
A
K
L
D
-
G
--
D
-
F
D
V
V
I
I
D
C
P
P
S
L
G
V
L
T
L
N
G
L
T
A
A
H
D
V
I
V
P
L
Q
C
E
T
L
A
H
R
G
V
G
Q
F
L
R
T
I
S
D
V
Q
Q
I
--
T
--
N
P
D
L
K
--
L
L
G
A
L
P
T
L
Y
-
D
-
S
R
T
T
H
S
-
R
--
D
V
-
L
L
-
D
V
A
D
R
Y
--
E
L
P
V
L
A
P
P
I
P
R
T
-----------------
R
K
S
K
G
A
I
A
Y
R
E
F
A
D
A
L
L
R
H
---------
132
HHSearch
75.55
25%
-105
- C2 -
1HYQ
-
?
A:
[2-233]
---------------------
V
R
T
I
T
V
A
S
G
K
G
G
T
G
K
T
T
I
T
A
N
L
G
V
A
L
A
Q
--
L
G
H
D
V
T
I
V
D
A
D
-
I
-
T
M
A
N
L
E
L
I
L
G
M
E
--------
G
-----
L
-----------
P
V
T
L
Q
N
---
V
L
A
G
E
A
R
I
-
D
E
A
I
Y
V
--
G
P
G
-
G
V
K
V
V
P
A
G
V
S
L
E
G
L
R
---------
K
--
A
-
N
P
E
K
L
E
D
V
L
T
Q
I
M
-
E
--
S
-
T
D
I
L
L
L
D
A
P
A
G
L
E
R
S
A
V
I
A
I
A
A
A
Q
E
L
L
L
V
V
N
P
E
I
S
S
I
T
D
G
L
K
T
K
I
V
A
E
R
L
----------
G
T
K
--
V
L
G
V
V
V
N
R
I
-
T
-
T
L
G
I
---
E
--
M
A
-
K
N
-
E
I
E
A
I
L
--
E
A
K
V
I
-
G
L
I
P
E
D
P
E
V
R
R
A
A
A
Y
G
K
P
V
V
L
R
S
P
N
S
P
A
A
R
A
I
V
E
L
A
N
Y
I
A
-----------
126
HHSearch
75.45
27%
-98
- C2 -
1G3Q
2
?
A:
[1-236]
--------------------
M
G
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
--
R
G
R
K
V
L
A
V
D
G
D
-
L
-
T
M
A
N
L
S
L
V
L
G
V
D
--------
D
-----
P
-----------
D
V
T
L
H
D
---
V
L
A
G
E
A
N
V
-
E
D
A
I
Y
M
-
T
Q
F
D
-
N
V
Y
V
L
P
G
A
V
D
W
E
H
V
L
------------
K
A
D
P
R
K
L
P
E
V
I
K
S
L
K
-
D
--
K
-
F
D
F
I
L
I
D
C
P
A
G
L
Q
L
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
I
S
C
L
T
D
T
M
K
V
G
I
V
L
K
K
A
----------
G
L
A
--
I
L
G
F
V
L
N
R
Y
-
G
-
R
S
D
R
------
D
I
-
P
P
E
A
A
E
D
V
M
--
E
V
P
L
L
-
A
V
I
P
E
D
P
A
I
R
E
G
T
L
E
G
I
P
A
V
K
Y
K
P
E
S
K
G
A
K
A
F
V
K
L
A
E
E
I
E
K
L
---------
155
Fugue
75.09
23%
-84
- C2 -
3Q9L
3
MIND_ECOLI
A:
[2-258]
---------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
--
K
G
K
K
T
V
V
I
D
F
A
-
I
G
L
-
R
N
L
D
L
I
M
G
C
E
--------
R
-----
R
--
V
--
V
-----
Y
D
F
V
N
V
---
I
Q
G
D
A
T
L
N
-
Q
A
L
I
K
D
-
K
R
T
E
-
N
L
Y
I
L
P
A
S
------
Q
T
--
R
D
K
--
D
A
--
L
T
R
E
-
G
V
A
K
V
L
D
D
L
K
-
A
M
-
D
-
F
E
F
I
V
C
D
S
P
A
G
I
E
T
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
G
I
L
A
S
K
S
R
R
--
A
--
E
N
G
E
E
PI
K
E
H
L
L
L
T
R
Y
N
P
-
G
R
V
S
R
G
-
D
--
M
L
S
M
E
-
D
V
L
E
I
L
--
R
I
K
L
V
-
G
V
I
P
E
D
Q
S
V
L
R
A
S
N
Q
G
E
P
V
I
L
-
D
I
N
A
D
A
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
E
R
P
FRFIEE
5
PsiBlast_PDB
74.98
28%
-90
- C2 -
1G3R
2
?
A:
[1-233]
--------------------
M
G
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
--
R
G
R
K
V
L
A
V
D
G
D
L
T
-
M
-
A
N
L
S
L
V
L
G
V
D
--------
D
-----
P
--
D
--
V
-------
T
L
H
D
---
V
L
A
G
E
A
N
V
-
E
D
A
I
Y
M
-
T
Q
F
D
-
N
V
Y
V
L
P
G
A
V
D
W
E
------
H
V
L
--
K
A
--
D
P
R
--
K
L
P
E
V
I
K
S
L
K
-
D
--
K
-
F
D
F
I
L
I
D
C
P
A
G
L
Q
L
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
------
I
S
C
L
T
D
T
M
K
V
G
I
V
L
--
K
--
K
A
G
L
A
--
I
L
G
F
V
L
N
R
Y
---
G
R
S
D
R
D
-
I
--
P
---
P
-
E
A
A
E
D
V
--
M
E
V
P
L
L
A
V
I
P
E
D
P
A
I
R
E
G
T
L
E
G
I
P
A
V
K
Y
K
P
E
S
K
G
A
K
A
F
V
K
L
A
E
E
I
------------
148
Fugue
74.52
25%
-85
- C2 -
2OZE
3
?
A:
[15-298]
ME
K
E
E
L
K
I
L
E
E
L
R
R
I
L
S
N
K
N
E
A
I
V
I
L
N
N
Y
F
K
G
G
V
G
K
S
K
L
S
T
M
F
A
Y
L
T
D
K
--
L
N
L
K
V
L
M
I
D
K
D
-
L
-
Q
-
A
T
L
T
K
D
L
A
K
T
--------
F
-----
K
VE
L
--
P
-----
R
V
N
F
Y
E
---
G
L
K
N
G
N
L
A
-
S
S
I
V
H
L
-
T
D
---
N
L
D
L
I
P
G
T
F
D
L
M
L
L
P
K
L
T
R
S
W
--
T
F
--
E
N
E
S
R
L
L
A
T
L
L
A
P
L
K
-
S
--
D
-
Y
D
L
I
I
I
D
T
V
P
T
P
S
V
Y
T
N
N
A
I
V
A
S
D
Y
V
M
I
P
L
Q
A
E
E
E
S
T
N
N
I
Q
N
Y
I
S
Y
L
I
D
L
Q
E
Q
--
F
--
N
P
G
L
D
--
M
I
G
F
V
P
Y
L
V
-
D
-
T
D
S
A
T
I
-
K
--
S
N
-
L
E
-
E
L
Y
K
Q
H
K
E
D
N
L
V
F
Q
N
I
I
K
R
S
N
K
V
S
T
W
S
K
N
G
I
T
E
H
K
G
Y
-
D
K
K
V
L
S
M
Y
K
N
V
F
F
E
M
L
E
R
I
I
Q
L
E
N
E
KE
11
PsiBlast_PDB
74.37
27%
-95
- C2 -
4V03
2
?
A:
[2-242]
---------------------
A
E
V
I
V
I
T
S
G
K
G
G
V
G
K
T
T
L
T
A
N
I
G
T
A
L
A
K
--
L
G
K
K
V
L
L
I
D
A
D
-----
R
N
L
D
M
I
L
G
L
---------
E
-----
N
--
R
--
I
-----
V
Y
D
I
L
D
---
V
L
E
G
R
V
P
Y
-
E
K
A
L
V
K
-
D
K
R
G
L
S
L
W
L
L
P
---------
V
-----------
I
D
I
E
-
K
W
N
K
T
V
E
E
I
K
-
N
SG
N
-
Y
D
Y
I
L
V
D
S
P
A
G
I
E
K
G
F
Q
I
A
V
S
P
A
D
K
A
L
I
V
V
N
P
E
V
S
S
I
R
D
A
D
R
V
I
G
L
L
E
S
M
D
K
R
-----
N
Y
K
V
I
--
V
N
R
I
K
W
E
M
V
-
K
-
R
G
A
M
L
S
-------
V
E
-
D
I
V
D
I
L
--
K
A
E
I
I
G
-
I
I
P
E
E
P
K
L
V
D
F
T
N
R
G
E
P
I
V
L
-
D
E
K
F
P
A
S
Q
A
I
I
D
T
A
R
R
L
M
G
E
---------
127
HHSearch
74.14
25%
-89
- C2 -
2OZE
3
?
A:
[36-289]
---------------------
A
I
V
I
L
N
N
Y
F
K
G
G
V
G
K
S
K
L
S
T
M
F
A
Y
L
T
D
K
--
L
N
L
K
V
L
M
I
D
K
D
-
L
-
Q
-
A
T
L
T
K
D
L
A
K
T
--------
F
-----
K
--
V
EL
P
-----
R
V
N
F
Y
E
---
G
L
K
N
G
-
N
L
-
A
S
S
I
V
H
--
L
T
D
-
N
L
D
L
I
P
G
T
F
D
L
M
L
L
P
K
--
L
T
R
--
S
W
T
F
E
N
E
S
R
L
L
A
T
L
L
A
P
L
K
-
S
--
D
-
Y
D
L
I
I
I
D
T
V
P
T
P
S
V
Y
T
N
N
A
I
V
A
S
D
Y
V
M
I
P
L
Q
A
E
E
E
S
T
N
N
I
Q
N
Y
I
S
Y
L
I
D
L
Q
E
Q
--
F
--
N
P
G
L
D
--
M
I
G
F
V
P
Y
L
V
-
D
-
T
D
S
A
T
I
-
K
--
S
N
-
L
E
-
E
L
Y
K
Q
H
K
E
D
N
L
V
F
Q
N
I
I
K
R
S
N
K
V
S
T
W
S
K
N
G
I
T
E
H
K
G
Y
D
-
K
K
V
L
S
M
Y
K
N
V
F
F
E
M
L
E
R
---------
13
PsiBlast_PDB
73.87
25%
-96
- C2 -
4V02
2
?
A:
[2-242]
---------------------
A
E
V
I
V
I
T
S
G
K
G
G
V
G
K
T
T
L
T
A
N
I
G
T
A
L
A
K
--
L
G
K
K
V
L
L
I
D
-----------
A
A
I
G
L
R
N
L
D
M
I
L
GL
E
-----
N
--
R
--
I
-----
V
Y
D
I
L
D
---
V
L
E
G
R
V
P
Y
-
E
K
A
L
V
K
-
D
K
R
G
L
S
L
W
L
L
P
A
-------
D
V
-----------
I
D
I
E
-
K
W
N
K
T
V
E
E
I
K
-
N
SG
N
-
Y
D
Y
I
L
V
D
S
P
A
G
I
E
K
G
F
Q
I
A
V
S
P
A
D
K
A
L
I
V
V
N
P
E
V
S
S
I
R
D
A
D
R
V
I
G
L
L
E
S
M
D
K
R
-----
N
Y
K
V
I
--
V
N
R
I
K
W
E
M
V
-
K
-
R
G
A
M
L
S
-------
V
E
-
D
I
V
D
I
L
--
K
A
E
I
I
G
-
I
I
P
E
E
P
K
L
V
D
F
T
N
R
G
E
P
I
V
L
-
D
E
K
F
P
A
S
Q
A
I
I
D
T
A
R
R
L
M
G
E
---------
6
PsiBlast_PDB
73.69
28%
-89
- C2 -
1ION
2
?
A:
[2-233]
---------------------
T
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
E
--
M
G
R
K
V
L
A
V
D
G
D
L
T
-
M
-
A
N
L
S
L
V
L
G
V
D
-----------------
D
--
V
-----
N
I
T
L
H
D
---
V
L
A
G
D
A
K
L
-
E
D
A
I
Y
M
-
T
Q
F
E
-
N
V
Y
I
L
P
G
A
V
D
W
E
------
H
V
I
--
K
A
--
D
P
R
--
K
L
P
E
V
I
K
S
L
K
-
G
--
K
-
Y
D
F
I
L
I
D
C
P
A
G
L
Q
L
R
A
M
S
A
M
L
S
G
E
E
A
I
L
V
T
N
P
E
------
I
S
C
L
T
D
T
M
K
V
G
M
V
L
--
K
--
K
A
G
L
A
--
I
L
G
F
I
L
N
R
Y
---
G
R
S
E
R
D
-
I
--
P
---
P
-
E
A
A
Q
D
V
--
M
D
V
P
L
L
A
V
I
P
E
D
P
V
I
R
E
G
T
L
E
G
I
P
A
V
K
Y
K
P
E
S
K
G
A
Q
A
F
I
K
L
A
E
E
V
------------
4
PsiBlast_PDB
73.69
28%
-87
- C2 -
1G3Q
2
?
A:
[1-233]
--------------------
M
G
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
--
R
G
R
K
V
L
A
V
D
G
D
L
T
-
M
-
A
N
L
S
L
V
L
G
V
D
--------
D
-----
P
--
D
--
V
-------
T
L
H
D
---
V
L
A
G
E
A
N
V
-
E
D
A
I
Y
M
-
T
Q
F
D
-
N
V
Y
V
L
P
G
A
V
D
W
E
------
H
V
L
--
K
A
--
D
P
R
--
K
L
P
E
V
I
K
S
L
K
-
D
--
K
-
F
D
F
I
L
I
D
C
P
A
G
L
Q
L
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
------
I
S
C
L
T
D
T
M
K
V
G
I
V
L
--
K
--
K
A
G
L
A
--
I
L
G
F
V
L
N
R
Y
---
G
R
S
D
R
D
-
I
--
P
---
P
-
E
A
A
E
D
V
--
M
E
V
P
L
L
A
V
I
P
E
D
P
A
I
R
E
G
T
L
E
G
I
P
A
V
K
Y
K
P
E
S
K
G
A
K
A
F
V
K
L
A
E
E
I
------------
133
HHSearch
72.58
23%
-87
* C2 *
3Q9L
3
MIND_ECOLI
A:
[2-249]
---------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
--
K
G
K
K
T
V
V
I
D
F
A
-
I
-
G
L
R
N
L
D
L
I
M
G
C
E
--------
R
-----
R
-----
V
-----
V
Y
D
F
V
N
---
V
I
Q
G
D
A
T
L
-
N
Q
A
L
I
K
D
K
R
T
E
-
N
L
Y
I
L
P
A
S
Q
T
R
D
K
D
A
-------------
L
T
R
E
G
V
A
K
V
L
D
D
L
K
A
M
--
D
-
F
E
F
I
V
C
D
S
P
A
G
I
E
T
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
G
I
L
A
S
K
S
R
R
A
E
N
--
G
E
E
P
I
--
K
E
H
L
L
L
T
R
Y
-
N
-
P
G
R
V
S
R
-
G
DM
L
S
-
M
E
-
D
V
L
E
I
L
--
R
I
K
L
V
-
G
V
I
P
E
D
Q
S
V
L
R
A
S
N
Q
G
E
P
V
I
L
D
-
I
N
A
D
A
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
---------
16
PsiBlast_PDB
71.83
23%
-99
- C2 -
3R9J
2
MIND_ECOLI
A:
[2-249]
---------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
--
K
G
K
K
T
V
V
I
D
F
-----------
A
I
G
L
R
--------
N
L
D
L
I
M
G
--
C
--
E
-----
R
R
V
V
Y
D
F
V
N
V
I
Q
G
D
A
T
L
N
Q
A
L
I
K
D
-
K
R
T
E
-
N
L
Y
I
L
P
A
S
------
Q
T
--
R
D
K
--
D
A
--
L
T
R
E
-
G
V
A
K
V
L
D
D
L
K
-
A
M
-
D
-
F
E
F
I
V
C
D
S
P
A
G
I
E
T
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
G
I
L
A
S
---------
G
E
E
P
I
--
K
E
H
L
L
L
T
R
Y
-
N
P
G
R
V
S
R
G
D
M
--
L
S
-
M
E
-
D
V
L
E
I
L
--
R
I
K
L
V
G
-
V
I
P
E
D
Q
S
V
L
R
A
S
N
Q
G
E
P
V
I
L
-
D
I
N
A
D
A
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
---------
14
PsiBlast_PDB
71.52
23%
-93
- C2 -
3Q9L
3
MIND_ECOLI
A:
[2-249]
---------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
--
K
G
K
K
T
V
V
I
D
F
-----------
A
I
G
L
R
--------
N
L
D
L
I
M
G
--
C
--
E
-----
R
R
V
V
Y
D
F
V
N
V
I
Q
G
D
A
T
L
N
Q
A
L
I
K
D
-
K
R
T
E
-
N
L
Y
I
L
P
A
S
------
Q
T
--
R
D
K
--
D
A
--
L
T
R
E
-
G
V
A
K
V
L
D
D
L
K
-
A
M
-
D
-
F
E
F
I
V
C
D
S
P
A
G
I
E
T
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
G
I
L
A
S
K
S
R
R
--
A
E
N
G
E
E
P
I
--
K
E
H
L
L
L
T
R
Y
-
N
P
G
R
V
S
R
G
D
M
--
L
S
-
M
E
-
D
V
L
E
I
L
--
R
I
K
L
V
G
-
V
I
P
E
D
Q
S
V
L
R
A
S
N
Q
G
E
P
V
I
L
-
D
I
N
A
D
A
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
---------
150
Fugue
71.45
28%
-93
- C2 -
3K9G
12
?
A:
[26-267]
--------------------
K
P
K
I
I
T
I
A
S
I
K
G
G
V
G
K
S
T
S
A
I
I
L
A
T
L
L
S
---
K
N
N
K
V
L
L
I
D
M
D
-
T
-
Q
-
A
S
I
T
S
Y
F
Y
E
K
--------
I
-----
E
--
K
--
L
GINFT
K
F
N
I
Y
E
---
I
L
K
E
N
V
D
I
-
D
S
T
I
I
N
-
V
D
-
N
-
N
L
D
L
I
P
S
Y
L
T
L
H
N
F
S
E
--
D
K
I
--
E
----
H
K
D
F
L
L
K
T
S
L
G
T
L
Y
-
Y
--
K
-
Y
D
Y
I
V
I
D
T
N
P
S
L
D
V
T
L
K
N
A
L
L
C
S
D
Y
V
I
I
P
M
T
A
E
K
W
A
V
E
S
L
D
L
F
N
F
F
V
R
----
K
--
L
--
N
L
F
L
P
--
I
F
L
I
I
T
R
F
K
-
K
-
N
R
T
H
K
T
-
L
--
F
E
-
I
L
-
K
T
K
D
R
F
--
L
G
T
I
S
E
N
------------------------
K
D
Y
I
K
E
Y
E
N
I
L
E
I
F
L
K
K
I
--------
147
HHSearch
22.52
37%
33
- C2 -
2WOJ
5
GET3_YEAST
A:
[17-116]
---------------------
T
H
K
W
I
F
V
G
G
K
G
G
V
G
K
T
T
S
S
C
S
I
A
I
Q
M
A
L
S
Q
P
N
K
Q
F
L
L
I
S
T
D
-
P
-
A
-
H
N
L
S
D
A
F
G
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------