@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2810: (2016-04-07 )
MQTYDAGTFDVIVVGAGHAGVEAGLASGRMGAKTLMLTINLDMVAFMPCNPSVGGPAKGVVVREIDALGGEMGRNTDKTYIQMRMLNTGKGPAVRALRAQADKWDYQHEMKHTIEKEENITLRQGLVDRLVIEDGVCKGVITNSGAIYYAKTVVITTGTFSRGEIIVGELRYSSGPNNQQPSVKLSEHLEELGFELRRFKTGTPPRVKSSTIDYSKTEEQPGDDHPRAFSFDTVEMLLDQLPCWLTYTNETTHEIIQANLHRSPMFTATKKGTGARYCPSIEDKIVRFSDKPRHQIFLEPEGKNTEEVYVQGLSTSLPEEVQREMLRTIPGLENVEMMRVGYAIEYDAVMPDQLWPSLETKLVEGLFTAGQINGTSGYEEAAGQGLMAGINAARKVFEKEPVILGRDQAYIGVLIDDLVTKGTEEPYRLLTSRAEYRLLLRHDNADLRLTEIGHEIGLISDERYERFLAKQSAIEAEKERLQKTRIKPTAEVQAMLKEIGSGELKDGILAADLLRRPEITYDKIAQIVSRETFVTDEIAEQVEIQIKYEGYIQKSNLQVEKMKRMEDKKIPENIDYDAISGLATEALEKLKKIEPLSIAQASRISGVNPADISILLVYIEQGKIAKISK
Atome Classification :
(20 SA)
.........10........20........30......-..40..---------......50......----..60........70--........80........90........100.......110...-....120-.......130..--.....140.......150.......160.......170.....-..180..-.....190........200.......210.......220.......230..-------..-.-...240........-250.......260.......270.......280...------....-------------290.......300........310.......320.......330.......340.......350........360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460--.......470.......480.......490.......500.......510.......520..------.....530------.-....-..540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQTYDAG
T
F
D
V
I
V
VGAGH
A
G
V
E
A
G
LASGRMG
A
K
T
L
M
L
-
T
I
NL
D
M
---------
V
A
F
MPCNPSVGGPA----K
G
V
V
V
R
E
I
D
A
LGGE--MGRNTD
K
T
Y
I
Q
M
R
M
LNTGK
G
P
A
V
R
A
L
R
AQADKW
D
Y
Q
H
E
M
K
H
T
I
E-KEEN
I
T
L
-
R
Q
G
L
V
D
R
L
V
IED--GVC
K
G
V
ITNS
G
A
I
Y
Y
A
K
T
V
V
I
TTGTFSRG
E
I
I
V
G
E
L
R
YSSGPN-NQQPS
V
K
-
L
S
E
H
L
E
E
-
L
G
F
E
L
R
R
FKTGTPPRVKSSTIDYSKTEEQPGDDHPRAF
S
F
-
D
T
-------
V
E
-
M
-
L
L
DQL-P
C
W
L
T
YTN-
E
T
T
H
E
I
I
Q
A
N
LHRSP
M
F
T
ATKKGTGARYCPS
I
E
D
K
I
------
V
RFS-------------DKPR
H
Q
I
F
LEP-EGKN
T
E
E
V
Y
V
QGLSTSL
P
E
E
V
Q
R
E
M
L
R
TIPGLEN
V
E
M
M
R
V
G
Y
A
I
E
YDAVM-
P
D
Q
LW
P
S
L
E
T
K
L
V
E
G
L
F
TAGQINGTSG
Y
E
E
A
AG
Q
G
L
M
A
G
I
N
A
A
R
K
V
F
EKE
P
V
I
LGRD
Q
A
Y
I
G
V
L
I
D
D
L
V
TKGTE
E
P
Y
R
L
L
TSRA
E
Y
R
L
L
L
R
HDNA
D
L
R
L
TEIGHEIGLI
S
D
E
--
R
Y
E
R
F
L
A
K
Q
S
A
I
E
A
E
K
E
R
L
Q
K
TRIK
P
T
A
E
V
Q
A
M
L
K
EIGS
G
E
L
K
D
G
I
L
A
A
D
L
LRRPEI
T
Y
D
K
I
------
A
Q
I
V
SRET------F-
V
T
D
E
-
I
A
E
Q
V
E
I
Q
I
K
Y
E
G
Y
I
QKSN
L
Q
V
E
K
M
K
R
M
EDKKIPENI
D
Y
D
A
I
S
G
L
A
T
E
A
L
E
K
L
KKIEPLS
I
A
Q
A
SRISGVNPA
D
I
S
I
L
L
V
Y
IEQGKIAKISK
23
PsiBlast_CBE
96.39
51%
-65
- C4 -
2ZXH
4
MNMG_AQUAE
B:
[28-633]
--------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
-
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
--
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
T
EPVGSYW
F
P
-
K
-
G
K
E
Q
V
-
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
-
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
------------------
R
S
Y
S
V
A
T
--
L
M
T
M
N
Y
T
L
D
D
V
------
K
E
K
F
G
Y
E
V
------
P
-
Q
H
P
Y
-
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
----------
3
PsiBlast_PDB
95.27
51%
-64
- C4 -
2ZXH
3
MNMG_AQUAE
A:
[28-633]
--------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
-
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
--
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
T
EPVGSYW
F
P
-
K
-
G
K
E
Q
V
-
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
-
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
------------------
R
S
Y
S
V
A
T
--
L
M
T
M
N
Y
T
L
D
D
V
------
K
E
K
F
G
Y
E
V
------
P
-
Q
H
P
Y
-
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
----------
22
PsiBlast_CBE
94.64
51%
-62
- C4 -
2ZXI
1
MNMG_AQUAE
C:
[28-633]
--------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
-
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
--
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
T
EPVGSYW
F
P
-
K
-
G
K
E
Q
V
-
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
-
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
----------
G
--
T
R
S
Y
S
V
A
T
--
L
M
T
M
N
Y
T
L
D
D
V
------
K
E
K
F
G
Y
E
V
------
P
-
Q
H
P
Y
-
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
----------
21
PsiBlast_CBE
94.62
51%
-63
- C4 -
2ZXI
1
MNMG_AQUAE
D:
[28-633]
--------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
A
D
T
---------
I
G
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
-
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
--
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
-
W
T
EPVGSYW
F
P
-
K
-
G
K
E
Q
V
-
N
C
W
I
T
Y
T
T
-
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
------
V
K
F
P
-------------
D
K
E
R
H
Q
I
F
L
E
P
-
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
----------
G
G
D
T
R
S
Y
S
V
A
T
--
L
M
T
M
N
Y
T
L
D
D
V
------
K
E
K
F
G
Y
E
V
------
P
-
Q
H
P
Y
-
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
----------
26
PsiBlast_CBE
93.49
49%
-64
- C4 -
3CP8
1
MNMG_CHLTE
B:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
-
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
--
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
S
-------
T
S
-
V
-
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
-
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
-
A
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
LEHSLS
V
R
S
A
A
E
E
L
------
C
-
N
D
P
R
-
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
4
PsiBlast_PDB
93.25
49%
-65
- C4 -
3CP8
1
MNMG_CHLTE
A:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
-
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
--
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
S
-------
T
S
-
V
-
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
-
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
-
A
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
A
E
E
L
------
C
-
N
D
P
R
-
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
85
HHSearch
93.03
49%
-62
- C4 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
------
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
-
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
--
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
-
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
S
-------
T
S
-
V
A
N
R
N
L
V
-
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
-
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
I
N
T
L
-
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
------
L
E
H
S
L
S
V
R
S
A
AE
E
L
C
-
N
D
P
R
-
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
25
PsiBlast_CBE
93.01
49%
-67
- C4 -
3CP8
1
MNMG_CHLTE
C:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
-
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
--
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
S
-------
T
S
-
V
-
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
-
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
-
A
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
LEHSLS
V
R
S
A
A
E
E
L
------
C
-
N
D
P
R
-
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
----------
2
PsiBlast_PDB
88.10
51%
-69
- C4 -
3CES
-
MNMG_ECOLI
A:
[7-550]
--------
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
--
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
-
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
--
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
-------
A
S
-
Q
-
H
P
Q
Q
V
-
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
-
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
------
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
24
PsiBlast_CBE
88.00
49%
-63
- C4 -
3CP8
1
MNMG_CHLTE
D:
[22-580]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
L
S
A
---------
V
A
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
--
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
-
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
--
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
-
S
S
-------
T
S
-
V
-
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
------
S
R
F
P
-------------
D
K
S
S
H
H
I
F
L
E
P
-
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
-
A
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
LEHSLS
V
R
S
A
A
E
E
L
------
C
-
N
D
P
R
-
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
---------------------------------------------------------------------
27
PsiBlast_CBE
86.73
51%
-65
- C4 -
3G05
3
MNMG_ECO57
B:
[33-576]
--------
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
--
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
-
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
--
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
-------
A
S
-
Q
-
H
P
Q
Q
V
-
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
-
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
------
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
5
PsiBlast_PDB
84.95
51%
-66
- C4 -
3G05
3
MNMG_ECO57
A:
[33-576]
--------
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
--
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
-
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
--
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
-------
A
S
-
Q
-
H
P
Q
Q
V
-
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
-
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
------
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
1
PsiBlast_PDB
82.69
51%
-69
- C4 -
3CP2
1
MNMG_ECOLI
A:
[27-573]
--------
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
--
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
-
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
--
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
-----------------------
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
-------
A
S
-
Q
-
H
P
Q
Q
V
-
P
C
Y
I
T
H
T
N
------------------------------------------------------------
D
R
N
Q
H
Q
I
F
L
E
P
-
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
------
T
T
L
T
P
F
A
P
------
A
-
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
----------------------------------------------------------------------------
86
HHSearch
55.42
26%
-40
- C5 -
3G5S
8
TRMFO_THET8
A:
[1-427]
-------
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
-
E
M
R
P
K
R
MTPAHGTDR
F
A
E
I
V
C
S
N
S
L
G
G
E
G
ETN
A
K
G
L
L
Q
A
E
M
R
R
A
G
S
L
--
V
M
E
A
A
D
L
A
R
----------
V
P
A
--
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
-
G
H
P
---------------------
L
L
E
V
V
R
E
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
---------------------
T
S
E
A
-
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
--------------------------
Y
L
-
N
C
P
M
T
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
P
H
---------
F
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLVDPRTG
K
E
P
F
A
V
V
Q
L
R
Q
-
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
P
P
V
A
P
-
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
A
N
P
E
G
F
Q
P
M
-----------------------
Y
A
N
W
G
L
V
P
P
V
EG
R
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
54.62
50%
35
- C4 -
3CES
-
MNMG_ECOLI
A:
[-8-550]
-
H
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
I
D
T
---------
L
G
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
--
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
-
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
--
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
-
M
G
-------
N
A
S
Q
-
H
P
Q
Q
V
-
P
C
Y
I
T
H
T
N
-
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
------
M
R
F
A
-------------
D
R
N
Q
H
Q
I
F
L
E
P
-
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
------
T
T
L
T
P
F
A
P
------
A
L
T
D
E
Q
-
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------
89
HHSearch
48.68
25%
-53
- C4 -
3F8D
2
?
A:
[11-127]
---
K
P
G
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
E
T
P
G
-----------
G
Q
L
T
E
----
A
G
I
------------
V
D
D
Y
L
G
-----------------------
L
--
I
----
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
-
K
-
Y
E
V
P
V
-
L
L
D
I
V
E
K
I
E
N
R
-----
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
46.73
25%
-54
- C4 -
2CUL
1
?
A:
[2-156]
------
A
A
Y
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
-
T
Q
S
L
D
A
----------
V
M
M
P
F
L
P
P
K
P
P
F
P
----
P
G
S
L
------------
L
E
R
A
Y
D
-----------
P
K
D
E
---------
R
V
W
A
F
H
A
R
A
K
Y
L
L
E
-
G
L
R
P
L
H
L
-
F
Q
A
T
A
T
G
L
L
L
E
G
--
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
G
V
V
E
E
A
G
R
L
-
S
E
A
S
Y
P
D
-
L
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
45.92
19%
-12
- C3 -
4OPU
3
?
A:
[2-453]
M
K
E
L
K
---
Y
D
V
L
I
I
G
G
G
F
A
G
S
S
A
A
Y
Q
L
S
R
R
G
L
K
I
L
L
V
D
S
K
P
W
N
R
---------
I
G
D
K
P
C
-------
G
----
D
A
V
S
K
A
H
F
D
K
L
G
M
P
YP
K
G
E
E
L
E
N
K
I
N
G
I
K
L
Y
S
P
--------------------
D
M
Q
T
V
W
T
V
N
H
E
G
F
E
L
-
N
A
P
L
Y
N
Q
R
V
L
K
E
--
A
Q
D
R
G
V
-----
E
I
W
D
L
T
T
A
M
K
P
I
F
E
---
D
G
Y
V
K
G
-
A
V
L
F
N
R
R
T
-
N
E
E
L
T
V
Y
-
S
K
V
V
V
E
A
-
T
G
Y
S
-
R
S
F
R
S
K
L
P
P
E
L
P
I
T
E
-----------
D
L
D
D
K
D
A
D
V
-
A
Y
-------
R
E
-
V
-
L
L
T
K
--------
E
D
-
I
E
D
H
D
Y
L
R
I
F
I
D
Q
E
-----
T
S
P
G
G
Y
W
W
Y
F
P
-------------
K
G
K
-------------
N
K
V
N
V
G
L
G
I
Q
G
G
M
G
Y
P
S
I
H
E
Y
Y
K
K
Y
L
D
K
Y
A
P
D
V
D
K
S
K
L
L
V
-
K
G
G
A
L
V
P
T
R
R
P
L
Y
T
M
A
W
N
G
I
I
-
V
----------
I
G
D
S
G
F
T
V
N
P
V
H
G
G
G
-----
K
G
S
A
M
I
S
G
Y
C
A
A
K
A
I
L
S
A
F
E
------------------------------------------
T
G
D
F
S
A
S
G
L
W
----
D
M
N
I
C
--
Y
V
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
------------------------------
L
S
N
D
D
I
N
Y
G
M
K
------
K
K
I
I
K
E
E
D
------
L
-
L
E
A
S
----------------
E
K
G
D
L
H
L
S
V
A
D
K
A
M
--
R
V
I
S
G
L
G
R
P
S
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
R
S
P
S
S
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
---
9
PsiBlast_PDB
45.91
21%
-58
- C4 -
2CUL
1
?
A:
[3-165]
-------
A
Y
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
-
T
Q
S
L
D
A
---------
V
M
M
P
F
L
P
P
K
P
P
F
P
P
----
G
S
L
L
E
R
A
Y
D
P
---------------------------------
K
D
E
R
V
W
A
F
H
A
R
A
K
Y
L
L
E
-
G
L
R
P
L
H
L
-
F
Q
A
T
A
T
G
L
L
L
E
G
--
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
G
V
V
E
E
A
G
R
L
-
S
E
A
S
Y
P
D
-
L
L
E
D
L
S
R
-
L
G
F
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
44.87
24%
-54
- C4 -
1HYU
2
AHPF_SALTY
A:
[208-333]
---
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
-
G
E
R
F
---------------------
G
G
Q
V
----
L
D
T
----
V
----
D
---
I
E
N
----------
Y
I
S
---
V
P
-------
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
-
D
-
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
TE
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------