@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0241: (2015-11-29 )
MKLIKLKKIVQIERKPFFITRQKLKLFRIVFNIIFVLMLFYYWSAIPLLLPRLIVVIFLLGSIFLTNKAFIAIKKRIGKTLFIRERLWYILESLKLYDSDGDRILNTAILTFDISNDNAVTISAPLFGDKWTKRLKNLEDNLVAGLGLPLLSKKELPNCVIYQLGHIEEIEQYVFNNNLTRKFFQSISSPVIKLSNTQQFSLKSNTNIGVYGRTGTGKTIALQWFLFNALAKGCGTDDSTYLGIVDGKGADLYALGKLLQEELGEQIAIGSSPQMLAKLSREFVDIMNARFEVIKQNSSLNADAYDLEMTPNFLFVDELASIRDSCGSSKQGKELWNEILQNLGLIARKGRQAGCHLLLSTQDPNAENIPVELRNQISAVLYLGNPGADRLKMAFSMCELENVPTVSDRKGEALFHADGLNSIEPVLTIVPFVDVKTKQDFLQIVRNILPNY
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.....-------...20.......--------.30---........40.....-...-50..---.-.-.-...60-........70....--------..-..80-........90....--------------------------------------....100.......110.......120.......130.....----..140.......150...-..--..--160...----...----.----170...-------------....-180.......190....-...200.......210.......220-------....-------------.-...230----------......------------.-240..--------.....250...-----------....260....-----...270....----...280.......290...---....300....------------------------------...310----------.------------------------------.--------------------------.-.-...320--.......330.------.....---------...340----.......--350.......-..360.....--------..370-------....--....-----380...-..-..-390-.......400....----.---..410.......420.......-.430........440......-.450--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK
L
I
K
L
K
K
I
V
Q
IERK
P
-------
F
F
I
T
R
Q
K
L
K
L
F
R
--------
I
V
F
---
N
I
I
F
V
L
M
L
F
Y
Y
W
S
A
I
-
P
L
L
-
L
P
R
L
---
I
-
V
-
V
-
I
F
L
L
G
-
S
I
F
LTN
K
A
F
I
A
I
K
K
--------RI-GKT
L
-
F
I
R
E
R
L
W
Y
I
L
E
S
L
K
--------------------------------------LYDSDG
D
R
I
L
N
T
A
I
L
T
F
DISND
N
A
V
T
I
SAPLF
G
D
K
W
T
K
R
L
K
N
----
L
E
D
N
L
V
A
GLGLPLLSKKE-LP--
N
C
--
V
I
Y
QLG----
H
I
E
----
E
----
I
E
Q
Y
V
F-------------NN
N
L
-
T
R
K
F
F
Q
S
ISS
P
V
I
K
LSN-
T
Q
Q
F
S
LKSNT
N
I
G
V
Y
GRTGTG
K
T
I
A
--------
L
Q
W
F
-------------
L
-
F
N
A
L
A
K----------GCGTDD------------S-
T
Y
L
G
I
--------VDGKG
A
D
L
Y
A
L
-----------
G
K
L
L
Q
E
ELGEQ-----IAIGS
S
P
Q
M
L
----
A
K
L
S
R
E
F
V
D
I
M
N
A
R
F
E
V
I
K---QNSSLNA
D
A
Y
D
------------------------------
L
EMTP
N
----------
F
------------------------------
L
--------------------------
F
-
V
-
D
E
L
A
S
I
--
R
D
SCGSS
K
--
Q
------
G
K
E
L
W
---------
N
E
I
L
Q
N
----
L
G
L
I
A
RK--G--RQAG
C
H
L
-
L
L
STQDPNAE--------NI
P
V
--------
E
L
R
N--QI
S
A
-----
V
L
Y
LGN-P
G
-
A
D
-
R
L
K
-
M
A
F
S
M
C
ELENVPTV----S---DRKG
E
A
L
F
HADGL-NSIEP
V
L
T
-
I
VP-FVDVK
T
K
Q
D
F
L
Q
I
V
R
N
I-LPNY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
84.15
18%
-91
- C5 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
-------
K
S
Y
S
P
E
S
L
E
A
M
S
--------
R
L
L
---
E
I
K
L
K
E
--
F
G
V
E
V
S
V
-
D
S
V
-
H
P
G
P
---
V
-
I
-
T
-
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
--------
D
L
-
A
R
S
L
-
A
V
I
--------
S
V
R
--------------------------------------
V
V
E
V
----
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
--
S
P
E
Y
D
E
----
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
-
I
T
--
D
------------------------------------------------------------------------
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
--------
V
N
A
M
-------------
L
-
L
S
I
L
F
K
----------
S
--
T
P
S
------------
E
-
A
R
L
I
M
--------
I
D
P
K
M
L
E
L
S
I
Y
-----------
E
G
I
P
H
L
-
L
C
P
V
-----
V
---
T
D
M
K
E
A
----
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
---
A
M
G
V
R
N
L
A
G
F
N
------------------------------
R
K
V
K
D
A
----------
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
P
T
I
V
V
--------------------------
V
-
V
-
D
E
F
A
D
M
--
M
M
I
V
G
--------------------------
K
K
V
E
E
L
----
I
A
R
I
A
Q
K
--
A
--
R
A
A
G
I
H
L
-
I
L
A
T
Q
R
P
S
V
D
--------
V
I
T
G
--------
L
I
K
A
--
N
I
P
T
-----
R
I
A
F
Q
V
-
S
S
-
K
I
-
D
S
R
-
T
I
L
D
Q
G
G
A
E
Q
L
L
-----------
G
H
G
D
M
L
Y
L
P
P
G
T
-
G
L
P
I
R
V
H
G
---
A
-
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
EDILA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
80.20
19%
-68
- C5 -
2IUT
3
FTSK_PSEAE
A:
[93-464]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
S
R
L
L
E
I
K
L
K
E
F
G
--------------------------------------
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
---------
A
G
V
K
V
S
R
-
I
S
N
----
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
GK
T
T
--
V
G
I
E
I
P
----
N
E
D
R
Q
M
V
R
----
F
S
E
V
L
S
-------------
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
-
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
--------
V
N
A
M
-------------
L
-
L
S
I
L
F
K
----------
S
--
T
P
S
------------
E
-
A
R
L
I
M
--------
I
D
P
K
M
L
E
L
S
I
Y
-----------
E
G
I
P
H
L
L
---------
C
P
V
V
T
D
M
K
E
A
----
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
---
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
P
T
I
----------
V
------------------------------
V
--------------------------
V
-
V
-
D
E
F
A
D
M
--
M
M
I
V
G
--------------------------
K
K
V
E
E
L
----
I
A
R
I
A
Q
K
--
A
--
R
A
A
G
I
H
L
-
I
L
A
T
Q
R
P
S
V
D
--------
V
I
T
G
--------
L
I
K
A
--
N
I
P
T
-----
R
I
A
F
Q
V
-
S
S
-
K
I
-
D
S
R
-
T
I
L
D
Q
G
G
A
E
Q
L
L
-----------
G
H
G
D
M
L
Y
L
P
P
G
T
---
G
L
P
I
R
V
-
H
G
A
-
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
-
G
A
P
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
80.02
17%
-68
- C5 -
2IUS
-
FTSK_ECOLI
A:
[863-1237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
A
R
L
V
E
A
R
L
A
D
F
R
--------------------------------------
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
--------
E
L
N
L
A
-
P
G
V
K
A
A
R
-
I
S
N
----
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
--
G
K
P
Y
V
G
L
E
L
P
----
N
K
K
----
R
Q
T
V
Y
L
R
E
V
L
D
-------------
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
E
-
P
V
V
A
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
--------
V
N
A
M
-------------
I
-
L
S
M
L
Y
K
----------
A
--
Q
P
E
------------
D
-
V
R
F
I
M
--------
I
D
P
K
M
L
E
L
S
V
Y
-----------
E
G
I
P
H
L
L
---------
T
E
V
V
T
D
M
K
D
A
----
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
---
A
L
G
V
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
L
--------
K
K
E
P
Y
I
----------
V
------------------------------
V
--------------------------
L
-
V
-
D
E
F
A
D
L
--
M
M
T
V
G
--------------------------
K
K
V
E
E
L
----
I
A
R
L
A
Q
K
--
A
--
R
A
A
G
I
H
L
-
V
L
A
T
Q
R
P
S
V
D
--------
V
I
T
G
--------
L
I
K
A
--
N
I
P
T
-----
R
I
A
F
T
V
-
S
S
-
K
I
-
D
S
R
-
T
I
L
D
Q
A
G
A
E
S
L
-----------
L
G
M
G
D
M
L
Y
S
G
P
N
S
---
T
L
P
V
R
V
-
H
G
A
-
F
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
73.98
18%
-98
- C5 -
4NH0
5
?
A:
[246-1147]
SANMT
L
T
S
L
L
HIDNPYNLD
P
A
V
L
W
RPRPQRNRLRVPIGLDADG
R
P
L
E
L
D
IKESAQGGMGP
H
G
L
C
I
G
A
TGSG
K
S
E
L
L
R
T
L
V
L
A
L
A
M
T
H
SPEV
L
N
F
V
L
V
D
FKGGATFLGMEGLRHVS
A
I
I
T
NLEEELP
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
GNYAS
L
R
D
Y
E
K
A
R
M
E
G
A
P
L
P
P
M
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
KPDF
A
E
L
F
V
M
I
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
-----------
L
E
E
G
K
L
R
G
L
D
--------
T
H
L
---
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
-
V
V
L
G
V
P
D
A
---
Y
-
E
-
L
-
P
P
S
P
G
-
N
G
Y
L
K
F
-------------------
A
T
E
P
-
L
V
R
F
K
A
A
Y
V
S
G
P
V
-----------------------------------------
D
E
E
S
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
G
P
E
P
H
Q
I
W
L
P
P
L
D
V
P
P
T
--
L
D
E
----
L
---------
L
P
P
L
S
P
S
A
-
A
H
--
G
Y
--
T
A
D
G
W
E
----
W
R
G
----
R
----
L
--
H
A
V
-------------
V
G
L
V
-
D
R
P
F
D
Q
R
R
D
P
Y
W
L
D
L
S
G
--------
G
A
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
M
--------
L
R
T
L
-------------
I
-
T
S
L
A
L
L
----------
H
--
T
P
Q
------------
E
-
V
Q
F
Y
C
--------
L
D
F
G
G
G
T
L
A
G
L
-----------
A
E
L
P
H
---
V
G
S
-----
V
A
T
R
L
D
A
D
R
I
----
R
R
T
V
A
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
---
E
R
G
I
D
S
M
A
T
Y
R
------------------------------
R
L
R
A
T
G
EYAGDGF
G
D
V
F
------------------------------
L
--------------------------
V
-
V
-
D
N
W
L
T
L
--
R
Q
D
------------------
Y
---------
E
A
L
E
D
S
----
I
T
Q
L
A
A
R
--
G
--
L
G
Y
G
I
H
V
-
V
L
S
S
N
--
K
W
S
--------
E
F
R
T
--------
S
I
R
D
--
L
L
G
T
-----
K
L
E
L
---
R
L
-
G
D
-
P
Y
E
-
S
E
V
D
R
K
K
A
A
N
V
P
------
E
---
N
R
P
G
R
G
L
T
R
-
D
G
Y
-----
H
F
L
T
-
A
L
P
-
R
I
D
G
D
T
S
A
E
T
L
T
E
G
I
A
T
-
T
V
K
T
I
R
E
A
W
HGPTAPPVRMLPNVLPAAQLPSAAESGTRIPIGIDEDSL
S
P
V
Y
L
D
FNTDP
H
F
L
V
F
G
D
T
ECG
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
TPQQ
A
R
L
I
F
IDYSRSLLDVATTEHQIGYAAS
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
LPPPDLT
P
E
Q
L
R
S
RSW
W
T
G
A
E
L
F
L
V
V
D
DYEMVATSDNPLRPLAELLPQARDIG
L
H
L
I
I
A
R
S
MGGAGRALYE
P
I
I
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
GNKDEGILLGN
V
K
P
H
KLPQG
R
G
Y
F
V
E
RRS
G
T
R
L
I
Q
T
A
Y
R
E
S
35
Fugue
61.84
10%
-64
* C4 *
1E32
1
TERA_MOUSE
A:
[21-458]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NR
P
N
R
L
I
V
D
E
A
I
N
E
D
N
S
V
-------
V
S
L
S
Q
P
K
M
D
E
L
Q
--------
L
F
R
---
G
-----------
D
T
V
-
L
L
K
-
G
K
K
R
---
R
-
E
-
A
-
V
C
I
V
L
-
S
D
D
T
C
S
D
E
K
I
R
M
N
R
--------
V
V
-
R
N
N
L
-
R
V
R
L
G
D
V
I
S
I
Q
P
C
P
---------------------------------------------
D
V
K
Y
G
K
R
I
H
V
L
P
I
D
D
T
V
E
G
I
T
G
N
L
F
E
V
Y
L
K
P
Y
F
L
E
----
A
Y
R
P
I
R
K
G
---
D
I
F
L
V
R
G
-
G
M
--
R
A
--
V
E
F
K
V
V
----
E
T
D
----
P
----
S
P
Y
C
I
V
-------------
A
P
D
T
-
V
I
H
C
E
G
E
P
I
K
R
E
D
E
E
E
S
-
L
N
E
V
G
Y
D
D
V
G
--
G
C
R
K
Q
L
A
Q
I
K
E
M
V
--------
E
L
P
L
-------------
R
-
H
P
A
L
F
K
----------
A
I
G
V
K
P
------------
P
-
R
G
I
L
L
--------
Y
G
P
P
G
T
G
K
T
L
I
-----------
A
R
A
V
A
N
E
T
G
A
F
-----
F
F
L
I
N
G
P
E
I
M
----
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
---
K
N
A
------------------------------------------
P
A
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
E
--
V
------
E
R
R
I
V
---------
S
Q
L
L
T
L
----
M
D
---
G
L
--
K
--
Q
R
A
H
V
I
V
-
M
A
A
T
N
R
P
N
S
I
--------
D
P
A
L
--------
R
R
F
G
--
R
F
D
R
-----
E
V
D
I
G
I
-
P
D
-
A
T
-
G
R
L
-
E
I
L
Q
I
-
H
T
K
N
M
K
L
A
----
D
---
D
V
D
L
E
Q
V
A
N
E
T
H
G
-
H
V
G
A
D
L
A
A
-
L
C
S
-
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
-
D
E
T
I
D
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
58.17
15%
-80
- C1 -
4K17
-
LR16A_MOUSE
A:
[10-669]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
R
E
L
M
E
S
I
K
D
V
I
GR
K
I
K
I
S
V
K
K
K
V
K
L
E
V
K
G
D
R
V
E
N
K
V
L
V
L
T
S
C
R
A
F
L
L
S
ARIPSKLE
L
T
F
---
S
Y
L
E
I
H
G
V
I
C
H
K
P
A
Q
M
V
V
E
-
T
E
K
C
---
N
M
S
M
K
M
V
S
P
E
D
-
V
S
E
V
L
A
H
I
G
T
C
L
R
R
I
FPGLS
P
L
R
I
M
K
K
V
S
M
E
P
S
E
R
L
A
S
L
Q
A
L
W
D
S
Q
TLAEPGPCGG
F
S
Q
M
Y
A
C
V
C
D
W
L
GFSYK
E
E
V
Q
W
D
V
D
T
I
Y
L
T
Q
D
T
R
E
L
N
L
Q
D
F
S
H
L
E
H
R
D
L
I
P
I
I
A
A
-
L
E
Y
N
Q
W
F
T
K
L
S
S
K
DLK
L
S
T
D
V
C
E
Q
I
L
R
V
V
S
R
S
N
R
-
L
E
--
E
L
--
V
L
E
N
A
G
LR
I
D
F
A
Q
----
K
----
L
A
G
A
L
A
H
NPNSGLH
T
I
N
LA
G
N
S
L
-
E
D
R
G
V
S
S
L
S
I
Q
F
A
K
L
P
K
G
L
K
H
L
N
L
-
S
K
T
S
L
S
P
K
G
V
N
S
L
C
Q
S
L
S
A
N
PLTAST
L
T
H
L
D
LSGNALRGDDL
S
H
M
Y
N
F
L
A
Q
PNTIV
H
L
D
LS
N
T
E
C
S
L
------------
E
M
V
C
S
A
L
--------
L
R
G
C
L
Q
C
L
A
V
L
N
LSRSVFSHRK
G
K
E
V
P
P
S
F
K
Q
F
-----
F
S
S
S
L
A
L
I
Q
I
NLSG
T
K
L
S
P
E
P
L
K
A
L
L
L
G
L
A
C
N
H
---
S
L
K
G
V
S
L
D
L
S
N
------------------------------
C
E
L
G
H
C
----------
L
------------------------------
R
S
GGAQVLEGCIAEIHNITSLDISDNG
L
-
E
-
S
D
L
S
T
L
--
I
V
W
L
S
K
N
R
--
S
------
I
Q
H
L
A
LGKNFNNMK
S
K
N
L
T
P
----
V
L
D
N
L
V
Q
M
-
I
--
Q
D
E
D
S
P
L
Q
S
L
S
L
A
D
S
K
L
K
--------
A
E
V
T
--------
I
I
I
N
--
A
L
G
S
NTSLT
K
V
D
I
S
G
-
N
G
M
G
D
M
G
A
K
M
L
A
K
A
L
Q
I
N
T
K
L
R
T
V
I
W
D
K
N
---
N
I
T
A
Q
G
F
Q
D
I
A
V
A
M
E
K
N
Y
T
L
R
F
M
P
I
P
M
Y
D
A
A
Q
A
L
K
T
N
P
E
K
T
E
E
A
-
L
Q
K
I
E
N
Y
L
L
R
N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
51.76
17%
-47
- C4 -
4J1Q
1
A:
[20-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H
M
E
R
L
M
L
E
P
V
W
E
K
Q
N
E
E
-------
L
S
Y
T
--------------------------------------------
E
H
---
I
-
I
-
V
-
L
F
----
E
T
E
R
S
V
T
D
S
I
A
S
H
M
--------
K
D
-
A
R
V
I
-
T
L
N
E
A
V
G
H
I
A
E
R
Y
Q
--------------------------------------
C
Y
M
Q
N
I
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
R
---
I
I
I
Q
A
I
V
P
L
E
K
------------
E
K
Q
L
F
A
G
V
S
G
L
F
K
T
A
E
I
-
E
F
--
S
K
--
L
T
A
Q
V
I
----
E
I
E
----
K
----
P
E
E
M
I
----------------
D
L
-
H
L
K
L
K
D
D
S
R
R
P
-----
F
-
D
K
Q
I
R
Y
E
A
G
Y
R
F
-
V
K
G
W
R
E
M
V
D
T
L
H
--------
M
P
W
-----------------------------------
R
D
E
------------
G
-
V
Y
L
-
I
--------
T
G
G
A
G
----
S
L
-----------
G
L
L
F
A
K
E
I
A
N
R
T
GR
S
T
I
V
L
T
G
R
S
V
L
S
----
E
D
K
E
N
E
L
E
A
L
R
S
I
G
A
E
V
V
Y
---
R
E
A
D
V
S
D
Q
H
A
V
------------------------------
R
H
L
L
E
E
----------
I
------------------------------
K
--------------------------
E
R
Y
-
G
T
L
N
G
I
--
I
H
G
A
G
S
S
K
--
D
R
F
IIHK
T
N
E
E
F
---------
Q
E
V
L
Q
P
K
V
S
G
L
L
H
V
D
E
C
--
S
--
K
D
F
P
L
D
F
-
F
I
F
F
S
S
V
S
G
C
--------
L
G
N
A
--------
G
Q
A
D
--
Y
A
A
A
-----
N
S
F
M
D
A
-
F
A
-
E
Y
-
R
R
S
-
L
A
A
S
K
K
R
F
G
S
T
I
S
F
----
N
WPL
W
E
E
G
G
M
Q
V
G
A
E
D
E
-
K
R
M
L
K
T
T
G
-
M
V
P
-
M
P
T
D
S
G
L
K
A
F
Y
Q
G
I
V
S
D
-
K
P
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
LL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.85
24%
-43
- C5 -
2IUU
1
FTSK_PSEAE
A:
[219-411]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
T
T
G
S
G
K
S
V
G
--------
V
N
A
M
-------------
L
-
L
S
I
L
F
K
----------
S
T
P
S
E
A
R
L
I
M
I
D
PKMLEL
S
-
I
Y
E
G
I
PHLLCPVV
T
D
M
K
E
A
A
N
A
L
R
-----------
W
S
V
A
E
M
E
R
R
Y
R
-----
L
M
A
A
M
G
V
R
N
L
----
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
PLF
R
R
E
S
P
D
D
E
P
P
Q
------------------------------
L
S
T
L
P
T
----------
I
------------------------------
V
--------------------------
V
-
V
V
D
E
F
A
D
M
--
M
M
I
V
G
--
K
--
K
------
V
E
E
L
--------------------
I
A
R
I
A
Q
K
--
A
--
R
A
A
G
I
H
L
-
I
L
A
T
Q
R
P
S
V
D
VITGLIKA
N
I
P
T
--------
R
I
A
F
--
Q
V
S
S
-----
K
I
D
S
R
T
-
I
L
-
D
Q
-
G
G
A
-
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
----
G
---
T
G
L
P
I
R
V
H
G
A
F
V
S
-
D
D
E
V
H
R
V
V
-
E
A
W
-
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
48.03
24%
-47
- C5 -
2IUT
2
FTSK_PSEAE
A:
[219-411]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
T
T
G
S
G
K
S
V
G
--------
V
N
A
M
-------------
L
-
L
S
I
L
F
K
----------
S
T
P
S
E
A
R
L
I
M
I
D
PKMLEL
S
-
I
Y
E
G
I
PHLLCPVV
T
D
M
K
E
A
A
N
A
L
R
-----------
W
S
V
A
E
M
E
R
R
Y
R
-----
L
M
A
A
M
G
V
R
N
L
----
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
PLF
R
R
E
S
P
D
D
E
P
P
Q
------------------------------
L
S
T
L
P
T
----------
I
------------------------------
V
--------------------------
V
-
V
V
D
E
F
A
D
M
--
M
M
I
V
G
--
K
--
K
------
V
E
E
L
--------------------
I
A
R
I
A
Q
K
--
A
--
R
A
A
G
I
H
L
-
I
L
A
T
Q
R
P
S
V
D
VIT
G
L
I
K
A
N
I
P
T
--------
R
I
A
F
--
Q
V
S
S
-----
K
I
D
S
R
T
-
I
L
-
D
Q
-
G
G
A
-
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
----
G
---
T
G
L
P
I
R
V
H
G
A
F
V
S
-
D
D
E
V
H
R
V
V
-
E
A
W
-
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
44.24
17%
-81
- C5 -
3EIE
1
VPS4_YEAST
A:
[110-194]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
Q
V
D
A
L
--
T
G
T
-----E-
A
------
S
R
R
I
K
---------
T
E
L
L
V
Q
----
M
N
G
V
G
----
N
--
D
S
Q
G
V
L
V
-
L
G
A
T
N
I
P
W
Q
----------
L
D
S
--------
A
I
R
R
--
R
F
E
R
-----
R
I
Y
I
P
L
-
P
D
-
L
A
-
A
R
T
-
T
M
F
E
I
N
V
G
D
T
P
C
V
L
----
T
---
K
E
D
Y
R
T
L
G
A
M
T
E
G
-
Y
S
G
S
D
I
A
V
-
V
V
K
-
D
A
L
M
Q
P
I
R
K
I
Q
S
A
T
H
F
K
-
D
V
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
43.07
21%
-70
- C5 -
3D8B
1
FIGL1_HUMAN
A:
[176-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
A
----------
V
------------------------------
I
--------------------------
F
-
I
-
D
E
I
D
S
L
--
L
S
Q
--------E
S
----
S
R
R
I
K
---------
T
E
F
L
V
Q
----
L
D
G
---------
S
E
D
R
I
L
V
-
V
G
A
T
N
R
P
Q
E
----------
I
D
E
--------
A
A
R
R
--
R
L
V
K
-----
R
L
Y
I
P
L
-
P
E
-
A
S
-
A
R
K
-
Q
I
V
I
N
L
M
S
K
E
Q
C
C
L
----
S
---
E
E
E
I
E
Q
I
V
Q
Q
S
D
A
-
F
S
G
A
D
M
T
Q
-
L
C
R
-
E
A
S
L
G
P
I
R
S
L
Q
T
V
R
P
I
A
-
Y
I
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
41.02
14%
-45
- C5 -
3WHK
1
PAN_PYRFU (first)
A:
[110-198]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
I
D
A
I
--
G
A
K
----------------
E
V
N
---------
R
T
L
M
Q
L
----
L
A
E
M
D
G
F
--
D
--
P
R
G
N
V
K
V
-
I
A
A
T
N
R
P
D
I
----------
L
D
P
--------
A
L
L
R
PG
R
F
D
R
-----
L
I
E
V
P
L
-
P
D
-
E
F
-
S
R
A
-
Q
I
L
Q
I
H
S
R
K
M
T
T
D
D
----
D
---
I
N
W
Q
E
L
A
R
S
T
D
E
F
-
N
G
A
Q
L
K
A
V
-
T
V
E
-
A
G
M
I
A
L
R
N
G
Q
S
S
V
K
H
E
D
-
F
V
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
40.84
13%
-70
- C5 -
3VFD
1
SPAST_HUMAN
A:
[207-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
Q
V
D
S
L
--
L
-------D-
A
------
S
R
R
L
K
---------
T
E
F
L
I
E
----
F
D
G
V
Q
----------
R
V
L
V
-
M
G
A
T
N
R
P
Q
E
----------
L
D
E
--------
A
V
L
R
--
R
F
I
K
-----
R
V
Y
V
S
L
-
P
N
-
E
E
-
T
R
L
-
L
L
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
39.94
10%
-41
- C2 -
2EUA
1
MENF_ECOLI
A:
[2-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
L
T
T
A
L
E
N
L
L
R
H
L
S
Q
-------
E
I
P
A
T
P
G
I
R
V
I
D
--------
I
P
F
P
LK
D
A
F
D
A
L
S
W
L
A
S
Q
Q
T
Y
-
P
Q
F
-
Y
W
Q
Q
RNG
D
-
E
-
E
-
A
V
V
L
G
-----
A
I
T
R
F
T
S
L
D
Q
--------
A
Q
-
R
F
L
R
-
Q
H
P
E
H
A
D
L
R
I
W
G
L
N
--------------------------------------
A
F
D
P
S
Q
G
N
L
L
L
P
R
L
E
W
R
R
C
G
G
K
A
T
L
R
L
T
L
F
S
-
E
S
S
L
Q
H
D
A
I
Q
----
A
K
E
F
I
A
-----
T
L
V
S
I
K
P
-
L
P
--
G
L
--
H
L
T
T
T
R
----
E
Q
H
----
W
----
P
D
K
T
G
W
-------------
T
Q
L
I
-
E
L
A
T
K
T
I
A
E
G
E
L
D
K
V
V
L
-
A
R
A
T
D
L
H
F
A
S
P
V
N
---------------------
A
A
A
-------------
M
-
M
A
A
S
R
R
----------
L
---
N
L
------------
N
-
C
Y
H
F
Y
--------
M
A
F
D
G
--------------------------
E
N
-----
A
F
L
G
S
S
P
E
R
L
----
W
R
R
R
D
K
A
L
R
T
E
A
L
A
G
T
V
A
N
---
N
P
D
D
K
Q
A
Q
Q
L
G
------------------------------
E
W
L
M
A
D
--------------------------------------------------------------------------
D
K
N
Q
--
R
E
N
M
L
V
V
E
--
D
------
I
C
Q
R
L
---------
Q
A
D
T
Q
T
-----
L
D
V
L
P
P
--
Q
--
V
L
R
L
R
K
V
-
Q
H
L
R
R
C
I
W
T
S
--------
L
N
K
A
--------
D
D
V
I
--
C
L
H
Q
-----
L
Q
P
T
A
A
V
A
G
-
L
P
-
R
D
L
-
A
R
Q
F
I
A
R
H
E
P
F
T
R
-----
E
---
W
Y
A
G
S
A
G
Y
L
S
L
Q
---
Q
S
E
F
C
V
S
-
L
-
R
-
S
A
K
I
S
G
N
V
V
R
L
Y
A
G
A
G
I
-
V
R
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
R
T
L
L
Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
39.88
20%
-49
- C5 -
2ZAN
2
VPS4B_MOUSE
A:
[227-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
I
D
S
L
--
C
G
S
R
S
E
N
E
SE
A
------
A
R
R
I
K
---------
T
E
F
L
V
Q
----
M
Q
G
V
G
----
V
--
D
N
D
G
I
L
V
-
L
G
A
T
N
I
P
W
V
----------
L
D
S
--------
A
I
R
R
--
R
F
E
K
-----
R
I
Y
I
P
L
-
P
E
-
A
H
-
A
R
A
-
A
M
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
38.90
31%
-33
- C5 -
1E9R
-
?
A:
[279-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
----------
W
------------------------------
L
--------------------------
F
-
I
-
D
E
L
A
S
L
--
E
K
L
--------------------------------
A
S
----
L
A
D
A
L
T
K
--
G
--
R
K
A
G
L
R
V
-
V
A
G
L
Q
S
T
S
Q
----------
L
D
D
V
YG
V
K
E
A
Q
T
L
R
A
--
S
F
R
S
-----
L
V
V
L
G
G
-
S
R
-
T
D
-
P
K
T
-
N
E
D
M
S
L
S
L
G
E
H
E
V
E
----
R
---
D
R
A
L
E
R
V
R
E
R
V
V
M
-
P
A
E
I
A
N
L
P
-
D
L
T
-
A
Y
V
G
F
A
G
N
R
P
I
A
K
V
P
L
E
-
I
K
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
38.28
18%
-70
- C5 -
2QP9
1
VPS4_YEAST
X:
[143-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
Q
V
D
A
L
--
T
G
----------------
S
E
A
S
---------
R
R
I
K
T
E
----
L
L
V
Q
M
N
G
VG-----
Q
G
V
L
V
-
L
G
A
T
N
I
P
W
Q
----------
L
D
S
--------
A
I
R
R
--
R
F
E
R
-----
R
I
Y
I
P
L
-
P
D
-
L
A
-
A
R
T
-
T
M
F
E
I
N
V
G
D
T
P
S
V
L
----
T
---
K
E
D
Y
R
T
L
G
A
M
T
E
G
-
Y
S
G
S
D
I
A
V
-
V
V
K
-
D
A
L
M
Q
P
I
R
K
I
Q
S
A
T
H
F
K
-
D
V
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
37.95
19%
-46
- C5 -
1XWI
2
VPS4B_HUMAN
A:
[105-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
I
D
S
L
--
C
G
S
R
S
E
N
----------
E
S
E
A
A
---------
R
R
I
K
T
E
----
F
L
V
Q
M
Q
G
--
V
GV
D
N
D
G
I
L
V
-
L
G
A
T
N
I
P
W
V
----------
L
D
S
--------
A
I
R
R
--
R
F
E
K
-----
R
I
Y
I
P
L
-
P
E
-
P
H
-
A
R
A
-
A
M
F
K
L
H
L
G
T
T
Q
N
S
L
----
T
---
E
A
D
F
R
E
L
G
R
K
T
D
G
-
Y
S
G
A
D
I
S
I
-
I
V
R
-
D
A
L
M
Q
P
V
R
K
V
Q
S
A
T
H
F
K
-
K
V
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
36.73
23%
-54
* C5 *
3CF2
1
TERA_MOUSE
A:
[297-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
L
D
A
I
--
A
P
K
R
E
K
T
H
----------
G
E
V
E
---------
R
R
I
V
S
Q
----
L
L
T
L
M
D
G
L-
K
--
Q
R
A
H
V
I
V
-
M
A
A
T
N
R
P
N
S
----------
I
D
P
--------
A
L
R
R
FG
R
F
D
R
-----
E
V
D
I
G
I
-
P
D
-
A
T
-
G
R
L
-
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
----
D
---
V
D
L
E
Q
V
A
N
E
T
H
G
H
-
V
G
A
D
L
A
A
L
-
C
S
E
-
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
-
E
T
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
35.75
18%
-65
- C5 -
3B9P
-
A:
[113-198]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
S
----------
I
------------------------------
I
--------------------------
F
-
I
-
D
E
V
D
S
L
--
L
S
E
R
----E-
A
------
S
R
R
L
K
---------
T
E
F
L
V
E
----
F
D
G
L
P
----------
R
I
V
V
-
L
A
A
T
N
R
P
Q
E
----------
L
D
E
--------
A
A
L
R
--
R
F
T
K
-----
R
V
Y
V
S
L
-
P
D
-
E
Q
-
T
R
E
-
L
L
L
N
R
L
L
Q
K
Q
G
S
P
L
----
D
---
T
E
A
L
R
R
L
A
K
I
T
D
G
-
Y
S
G
S
D
L
T
A
-
L
A
K
-
D
A
A
L
E
P
I
R
E
L
N
I
S
A
M
R
A
-
I
T
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------