@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0256: (2015-11-29 )
MTKYIKADRFFYADHVKENGYLEIKDNHFGKWIENISGQEEILDYSGYQIAPGLVDTHIHGFAGADVMDCDSEGILRMSAGLLSTGVTSFLPTTLTSDTKRLEEASKSVAAVAGKEQGAKIQGIYFEGPYFTEEYKGAQNPIYMRNPNLEEFAQWQKAAKGLITKIALAPEREGVEEFVSAITKQGVTVALGHSNGTYKEAKKAVKAGASVWVHAYNGMRGLTHREPGMVGAVYNLPNTYAELICDGHHVDPVACDILMTQKGHNHVALITDCMAAGGAPDGDYMLGELPVVVSNGTARLKDGGNLAGSILKLKDGLKNVVEWGIATPEEAVRMASYVPAVSVGIDNVCGQIKEGYAADFIVLDKHLDLVATYLDGEKRWQS
Atome Classification :
(20 SA)
.........10....-.----....20........30.....---.---..-------40........50........60....--.-----------.--------..-----------70.----..-----.----.-....80........90.......----.-100.......110--.--......120.......130.....---------------..140...-..--..150.......---160---........-----------.170.------...-.....180.......190.......200....-...210-........220.......230.......240.......250....--...260.----.....----..270.......280.......290.....----..----300.....---..-310.......320--.------------.-----.....330.......340.......350.......360....----------.----------------------..370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTK
Y
I
KAD
R
F
-
F
Y
A
D
-H----VKENG
Y
L
E
I
KDN
H
F
G
K
W
I
E
NI---S---
G
Q
-------
E
E
I
LDYSG
Y
Q
IAP
G
L
V
D
T
HIHGFAGA--D-----------V--------MD-----------C-D----SE-----
G
----
I
-
L
R
M
S
A
G
L
L
S
T
G
V
T
S
FLPTTLT
S
D
----
T
-
K
R
L
E
E
A
S
K
S
V
A
A
V--A--GKEQG
A
K
I
Q
G
I
Y
FEGPY
F
T
E
EYKG---------------AQN
P
I
Y
MR-NP--
N
L
E
E
F
A
Q
W
Q
K
A
A
---
K
-----
G
L
I
T
K
I
AL-----------AP--
E
------
R
E
G
-
V
E
E
F
V
S
A
I
T
KQ
G
V
T
V
A
L
GHSNG
T
Y
K
E
A
K
K
A
V
K-AG
A
S
V
--
W
V
H
A
YNGMRGLTHREPG
M
V
G
A
VYNL
P
N
T
Y
A
E
L
ICDGHHVD
P
V
A
C
D
--
I
L
MT-QK----GH
N
H
V
----
A
L
I
T
D
C
M
AAGGAPDGD
Y
M
LGEL
P
V
V
VSNG
T
----
A
R----LKDGG
N
L
A
---
G
S
-
I
L
K
L
K
D
G
L
K
N
V
V
E
--W------------G-----IA
T
P
E
E
A
V
R
M
A
SYVP
A
V
S
V
G
I
D
N
V
C
G
Q
I
K
EGYAA
D
F
I
V
LDK
H
----------
L
----------------------
D
L
V
A
T
Y
LDG
E
K
RWQS
1
PsiBlast_PDB
97.03
33%
-80
- C1 -
2VHL
4
NAGA_BACSU
A:
[7-384]
----
I
K
D
I
A
I
-
V
T
E
N
-
E
----
V
I
K
N
G
Y
V
G
I
N
D
---
G
K
-
I
S
T
V
---
S
---
T
E
RPKEPYS
K
E
I
Q
A
P
A
D
S
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
--
D
-----------
T
--------
M
D
-----------
A
-
S
----
F
S
-----
T
----
L
-
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
H
G
N
I
S
-
Q
A
L
V
N
A
R
E
W
K
A
A
E
--
E
--
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
---------------
A
Q
P
K
E
W
I
R
-
P
S
--
D
V
E
L
F
K
K
W
Q
Q
E
A
---
G
-----
G
L
I
K
I
V
T
L
-----------
A
P
--
E
------
E
D
Q
-
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
-
A
G
A
S
H
--
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
--
L
A
F
L
-
A
K
----
G
S
S
K
L
----
I
L
I
T
D
S
M
R
A
K
G
L
K
D
G
V
Y
E
F
G
G
Q
S
V
T
V
R
G
R
T
----
A
L
----
L
S
D
-
G
T
L
A
---
G
S
-
I
L
K
M
N
E
G
A
R
H
M
R
E
--
F
------------
T
-----
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
----------
C
----------------------
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
21
PsiBlast_CBE
96.42
33%
-77
- C1 -
2VHL
4
NAGA_BACSU
B:
[7-384]
----
I
K
D
I
A
I
-
V
T
E
N
-
E
----
V
I
K
N
G
Y
V
G
I
N
D
---
G
K
-
I
S
T
V
---
S
---
T
E
RPKEPYS
K
E
I
Q
A
P
A
D
S
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
--
D
-----------
T
--------
M
D
-----------
A
-
S
----
F
S
-----
T
----
L
-
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
H
G
N
I
S
-
Q
A
L
V
N
A
R
E
W
K
A
A
E
--
E
--
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
---------------
A
Q
P
K
E
W
I
R
-
P
S
--
D
V
E
L
F
K
K
W
Q
Q
E
A
---
G
-----
G
L
I
K
I
V
T
L
-----------
A
P
--
E
------
E
D
Q
-
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
-
A
G
A
S
H
--
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
--
L
A
F
L
-
A
K
----
G
S
S
K
L
----
I
L
I
T
D
S
M
R
A
K
G
L
K
D
G
V
Y
E
F
G
G
Q
S
V
T
V
R
G
R
T
----
A
L
----
L
S
D
-
G
T
L
A
---
G
S
-
I
L
K
M
N
E
G
A
R
H
M
R
E
--
F
------------
T
-----
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
----------
C
----------------------
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
75
HHSearch
91.30
31%
-80
- C1 -
1O12
1
?
A:
[13-375]
--
M
I
V
E
K
V
L
I
-
V
D
P
I
D
G
----
E
F
-
T
G
D
V
E
I
E
E
G
K
I
V
K
V
E
K
R
E
--------------------
C
I
P
R
G
V
L
M
P
G
F
V
D
P
H
I
H
G
V
V
G
A
--
D
-----------
T
--------
M
N
-------------------
C
-----
D
----
F
-
S
E
M
E
E
F
L
Y
S
Q
G
V
T
T
F
L
A
T
T
V
S
T
S
----
L
-
E
K
M
K
E
I
L
R
K
A
R
D
Y
--
I
--
L
E
N
P
S
T
S
L
L
G
V
H
L
E
G
P
Y
I
S
K
E
K
K
G
---------------
A
H
S
E
K
H
I
R
-
P
P
--
S
E
R
E
L
S
E
I
-------
D
-----
S
P
A
K
M
L
T
F
-----------
A
P
--
E
------
I
E
S
-
S
E
L
-
L
L
R
L
V
K
R
D
I
V
L
S
A
G
H
S
I
A
T
F
E
E
F
M
K
F
Y
K
-
E
G
V
K
R
--
I
T
H
F
P
N
G
L
K
P
L
H
H
R
E
I
G
I
T
G
A
G
L
L
L
D
D
V
K
L
E
L
I
C
D
G
V
H
L
S
R
E
M
V
K
--
L
V
Y
K
-
V
K
----
K
A
N
G
I
V
L
V
T
D
S
I
S
A
A
G
L
K
D
G
T
T
----
T
L
G
D
L
V
V
K
V
K
D
G
V
----
P
R
-----
L
E
D
G
T
L
A
---
G
S
-
T
L
F
F
S
Q
A
V
K
N
F
R
K
--
F
------------
T
-----
G
C
S
I
T
E
L
A
K
V
S
S
Y
N
S
C
V
E
L
G
L
D
-
D
R
G
R
I
A
E
G
T
R
A
D
L
V
L
L
D
E
D
----------
L
----------------------
N
V
V
M
T
I
K
E
G
E
V
V
F
R
S
72
HHSearch
90.18
29%
-59
- C1 -
2VHL
4
NAGA_BACSU
A:
[3-389]
E
S
L
L
I
K
D
I
A
I
-
V
T
E
N
-
E
----
V
I
K
N
G
Y
V
G
I
N
D
G
K
I
S
T
V
S
T
E
R
---
P
KEP
Y
S
-------
K
E
I
Q
A
P
A
D
S
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
--
D
-----------
T
--------
M
D
-----------
A
-
S
----
F
S
-----
T
----
L
-
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
----
H
-
G
N
I
S
Q
A
L
V
N
A
R
E
W
K
A
A
EE
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
---------------
A
Q
P
K
E
W
I
R
-
P
S
--
D
V
E
L
F
K
K
W
Q
Q
E
A
---
G
-----
G
L
I
K
I
V
T
L
-----------
A
P
--
E
------
E
D
Q
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
-
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
-
A
G
A
S
H
--
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
--
L
A
F
L
-
A
K
GS--
S
K
L
I
L
----
I
T
-
D
S
M
R
-
A
K
G
L
K
D
G
V
------
Y
E
F
G
G
Q
S
V
T
V
R
G
R
T
----
A
L
L
S
D
G
T
L
A--
G
S
-
I
L
K
M
N
E
G
A
R
H
M
R
E
--
F
------------
T
-----
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
----------
C
----------------------
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
23
PsiBlast_CBE
89.70
33%
-79
- C1 -
3IV8
3
NAGA_VIBCH
C:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
--
P
--
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
----
K
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-
73
HHSearch
88.92
29%
-72
* C1 *
3IV8
3
NAGA_VIBCH
A:
[3-381]
A
M
Y
A
L
T
N
C
K
I
-
Y
T
G
N
-
D
----
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
P
I
E
SL-
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
-----------
E
I
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
-----
Q
A
K
Y
P
N
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
-
P
---
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
-----
G
E
K
L
----
V
L
V
T
D
A
T
A
P
A
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
------------
V
-----
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-
2
PsiBlast_PDB
88.76
34%
-84
- C1 -
1O12
1
?
A:
[53-375]
--------------------------------------------------------------------
L
M
P
G
F
V
D
P
H
I
H
G
V
V
G
A
--
D
-----------
T
--------
M
N
-----------
C
-
D
----------------
F
-
S
E
M
E
E
F
L
Y
S
Q
G
V
T
T
F
L
A
T
T
V
S
T
S
----
L
-
E
K
M
K
E
I
L
R
K
A
R
D
Y
--
I
--
L
E
N
P
S
T
S
L
L
G
V
H
L
E
G
P
Y
I
S
K
E
K
K
G
---------------
A
H
S
E
K
H
I
R
-
P
P
--
S
E
R
E
L
S
E
I
D
S
P
A
---
K
-----
M
L
----
T
F
-----------
A
P
--
E
------
I
E
S
--
S
E
L
L
L
R
L
V
K
R
D
I
V
L
S
A
G
H
S
I
A
T
F
E
E
F
M
K
F
Y
K
-
E
G
V
K
R
--
I
T
H
F
P
N
G
L
K
P
L
H
H
R
E
I
G
I
T
G
A
G
L
L
L
D
D
V
K
L
E
L
I
C
D
G
V
H
L
S
R
E
M
V
K
--
L
V
Y
K
-
V
K
----
K
A
N
G
I
----
V
L
V
T
D
S
I
S
A
A
G
L
K
D
G
T
T
T
L
G
D
L
V
V
K
V
K
D
G
V
----
P
R
----
L
E
D
-
G
T
L
A
---
G
S
-
T
L
F
F
S
Q
A
V
K
N
F
R
K
--
F
------------
T
-----
G
C
S
I
T
E
L
A
K
V
S
S
Y
N
S
C
V
E
L
G
L
D
D
R
-
G
R
I
A
E
G
T
R
A
D
L
V
L
L
D
E
D
----------
L
----------------------
N
V
V
M
T
I
K
E
G
E
V
V
F
R
S
4
PsiBlast_PDB
88.74
33%
-77
- C1 -
3IV8
3
NAGA_VIBCH
A:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
--
P
--
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
----
K
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-
22
PsiBlast_CBE
88.65
33%
-83
- C1 -
3IV8
3
NAGA_VIBCH
D:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
--
P
--
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
-------------------------------
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-
3
PsiBlast_PDB
88.34
33%
-80
- C1 -
3EGJ
2
NAGA_VIBCH
A:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
--
P
--
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
----
K
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
--
24
PsiBlast_CBE
88.08
33%
-78
- C1 -
3IV8
3
NAGA_VIBCH
B:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
---------------
I
H
S
V
D
F
I
R
--
P
--
S
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
----
K
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-
25
PsiBlast_CBE
87.95
33%
-87
- C1 -
3EGJ
2
NAGA_VIBCH
B:
[37-377]
--------------------------------------
I
E
S
L
---
P
---
S
E
-------
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
--
M
-----------
F
--------
N
D
E----------
I
-
T
----
A
E
-----
T
----
I
-
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
----
D
-
E
N
M
R
Q
A
I
A
A
A
R
E
Y
--
Q
--
A
K
Y
P
N
Q
S
L
-
G
L
H
L
E
G
P
-------------------------------------
D
D
T
M
I
D
T
I
C
A
N
---
S
-----
D
V
I
A
K
V
T
L
-----------
A
P
--
E
------
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
-
S
G
I
T
F
--
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
--
I
A
H
K
-
I
K
----
G
E
K
L
V
-----
L
V
T
D
A
T
A
P
A
G
A
-
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
----
K
C
----
V
D
E
N
G
T
L
G
---
G
S
-
A
L
T
M
I
E
A
V
Q
N
T
V
E
--
H
V-----------
G
-----
I
A
L
-
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
----------
F
----------------------
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
--
74
HHSearch
85.56
26%
-81
- C1 -
1YRR
4
NAGA_ECOLI
A:
[1-381]
-
M
Y
A
L
T
Q
G
R
I
-
F
T
G
H
-
E
----
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
P
V
A
---
E
LP-
P
E
-------
I
E
Q
R
S
L
N
G
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
--
Q
-----------
F
--------
N
D
-----------
T
-
A
EAVS
V
E
-----
T
----
L
-
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
----
D
-
E
L
M
K
Q
G
V
R
V
M
R
E
Y
--
L
--
A
-
K
H
P
N
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
----------------
T
H
N
P
N
F
V
R
-
K
P
---
D
A
A
L
V
D
F
L
C
E
N
---
A
-----
D
V
I
T
K
V
T
L
-----------
A
P
--
E
------
M
V
--
P
A
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
-
A
G
I
T
F
--
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
--
N
A
K
R
-
L
K
----
G
-
D
K
L
----
C
L
V
T
D
A
T
A
P
A
--------
G
A
N
I
E
Q
F
I
F
A
G
K
----
T
I
Y
YRN
G
L
C
V
D
E
N
G
TLS
G
S
-
S
L
T
M
I
E
G
V
R
N
L
V
E
--
H
------------
C
-----
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
----------
F
----------------------
K
I
T
K
T
I
V
N
G
N
E
V
V
T
Q
7
PsiBlast_PDB
85.24
29%
-80
- C1 -
2P50
1
NAGA_ECOLI
A:
[47-378]
----------------------------------------------------------------
N
G
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
--
Q
-----------
F
--------
N
D
TAEA-------
V
-
S
----
V
E
-----
T
----
L
-
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
----
D
-
E
L
M
K
Q
G
V
R
V
M
R
E
Y
--
L
--
A
K
H
P
N
Q
A
L
-
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
---------------
T
H
N
P
N
F
V
R
-
K
P
--
D
-
A
A
L
V
D
F
L
C
E
N
---
A
-----
D
V
I
T
K
V
T
L
-----------
A
P
--
E
------
M
V
P
-
A
E
-
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
-
A
G
I
T
F
--
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
--
N
A
K
R
-
L
K
----
G
-
D
K
L
----
C
L
V
T
D
A
T
A
P
A
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
----
C
-----
V
D
E
N
G
T
L
S
---
G
S
-
S
L
T
M
I
E
G
V
R
N
L
V
E
H-
C
------------
G
-----
I
A
L
-
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
----------
F
----------------------
K
I
T
K
T
I
V
N
G
N
E
V
V
T
Q
5
PsiBlast_PDB
84.53
29%
-89
- C1 -
1YMY
-
NAGA_ECOLI
A:
[47-378]
----------------------------------------------------------------
N
G
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
--
Q
-----------
F
--------
N
D
TAEA-------
V
-
S
----
V
E
-----
T
----
L
-
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
----
D
-
E
L
M
K
Q
G
V
R
V
M
R
E
Y
--
L
--
A
K
H
P
N
Q
A
L
-
G
L
H
L
E
G
P
W
L
N
L
V
---------------------
P
N
F
V
R
-
K
P
--
D
-
A
A
L
V
D
F
L
C
E
N
---
A
-----
D
V
I
T
K
V
T
L
-----------
A
P
--
E
------
M
V
P
-
A
E
-
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
-
A
G
I
T
F
--
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
--
N
A
K
R
-
L
K
----
G
-
D
K
L
----
C
L
V
T
D
A
T
A
P
A
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
----
C
-----
V
D
E
N
G
T
L
S
---
G
S
-
S
L
T
M
I
E
G
V
R
N
L
V
E
H-
C
------------
G
-----
I
A
L
-
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
----------
F
----------------------
K
I
T
K
T
I
V
N
G
N
E
V
V
T
Q
8
PsiBlast_PDB
84.43
29%
-81
- C1 -
2P53
3
NAGA_ECOLI
A:
[47-378]
----------------------------------------------------------------
N
G
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
--
Q
-----------
F
--------
N
D
TAEA-------
V
-
S
----
V
E
-----
T
----
L
-
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
----
D
-
E
L
M
K
Q
G
V
R
V
M
R
E
Y
--
L
--
A
K
H
P
N
Q
A
L
-
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
---------------
T
H
N
P
N
F
V
R
-
K
P
--
D
-
A
A
L
V
D
F
L
C
E
N
---
A
-----
D
V
I
T
K
V
T
L
-----------
A
P
--
E
------
M
V
P
-
A
E
-
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
-
A
G
I
T
F
--
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
--
N
A
K
R
-
L
K
----
G
-
D
K
L
----
C
L
V
T
N
A
T
A
P
A
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
----
C
-----
V
D
E
N
G
T
L
S
---
G
S
-
S
L
T
M
I
E
G
V
R
N
L
V
E
H-
C
------------
G
-----
I
A
L
-
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
----------
F
----------------------
K
I
T
K
T
I
V
N
G
N
E
V
V
T
Q
6
PsiBlast_PDB
83.75
29%
-86
- C1 -
1YRR
4
NAGA_ECOLI
A:
[47-378]
----------------------------------------------------------------
N
G
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
--
Q
-----------
F
--------
N
D
TAEA-------
V
-
S
----
V
E
-----
T
----
L
-
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
----
D
-
E
L
M
K
Q
G
V
R
V
M
R
E
Y
--
L
--
A
K
H
P
N
Q
A
L
-
G
L
H
L
E
G
P
W
L
N
L
V
K
K
----------------
T
H
N
P
N
F
V
R
-
K
P
--
D
-
A
A
L
V
D
F
L
C
E
N
---
A
-----
D
V
I
T
K
V
T
L
-----------
A
P
--
E
------
M
V
P
-
A
E
-
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
-
A
G
I
T
F
--
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
--
N
A
K
R
-
L
K
----
G
-
D
K
L
----
C
L
V
T
D
A
T
A
P
A
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
----
C
-----
V
D
E
N
G
T
L
S
---
G
S
-
S
L
T
M
I
E
G
V
R
N
L
V
E
H-
C
------------
G
-----
I
A
L
-
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
----------
F
----------------------
K
I
T
K
T
I
V
N
G
N
E
V
V
T
Q
92
HHSearch
65.53
19%
-58
- C1 -
3HPA
1
?
A:
[30-451]
-
T
L
L
V
K
H
A
D
V
L
V
T
M
D
-
D
TR
R
-
E
L
R
D
A
G
L
Y
I
E
D
N
R
I
V
A
V
G
P
S
A
---
E
LPE
T
A
-------
D
E
V
L
D
L
R
G
H
L
V
I
P
G
L
V
N
T
H
H
H
M
Y
Q
S
L
TR
A
-----------
V
PAAQNAE
L
F
G
W
L
T
N
L
Y
K
I
W
A
H
L
-
T
----
P
E
-----
M
I
E
V
S
T
-
L
T
A
M
A
E
L
L
Q
S
G
C
T
T
S
S
D
H
L
Y
I
Y
P
----
N
G
S
R
L
D
D
S
I
G
A
A
Q
---------
R
I
G
M
R
F
H
---
A
S
R
G
A
M
S
----------------------------E
P
D
--
I
L
R
D
T
Q
R
L
I
E
T
Y
---
H
DEGRY
A
M
L
R
V
-
V
V
-----------
A
P
--
C
SPFSVS
R
D
L
-
M
R
D
A
A
V
L
A
R
E
Y
G
V
S
L
H
T
-
H
L
A
E
N
V
N
D
I
A
Y
-------
T
P
--
A
E
Y
A
E
D
-
L
--------
G
W
V
G
--------
H
D
V
W
H
A
H
C
V
Q
L
D
D
A
G
I
G
--
L
F
A
R
-
T
G
----
T
G
V
A
H
----
C
P
C
S
N
M
R
L
A
S
G
I
-------
A
P
V
K
K
M
R
L
A
G
V
----
P
V
----
G
L
G
V
D
G
S
A
---
S
N
D
G
A
Q
M
V
A
E
V
R
Q
A
L
L
L
Q
R
------------
V
G
FGPD
A
M
T
A
R
E
A
L
E
I
A
T
L
G
G
A
K
V
L
N
R
D
-
D
I
G
A
L
K
P
G
M
A
A
D
F
A
A
F
D
L
R
QPLFAGALHD
P
V
A
A
L
V
F
C
A
P
S
------------
Q
T
A
Y
T
V
V
N
G
K
V
V
V
R
E
82
HHSearch
64.78
19%
-48
- C1 -
2QS8
2
?
A:
[8-411]
-
K
T
L
I
H
A
G
K
L
-
I
D
G
K
-
S
DQ--
V
Q
S
R
I
S
I
V
I
D
G
N
I
I
S
D
I
K
K
G
F
ISS
N
---
D
F
-------
E
D
Y
I
D
L
R
D
H
T
V
L
P
G
L
M
D
M
H
V
H
F
G
Q
E
Y
--
Q
S
KA--------
Q
--------
A
P
-----------
I
-
K
----
V
E
R
E
M
Q
A
I
----
L
A
T
Q
H
A
Y
V
T
F
K
S
G
F
T
T
V
R
Q
V
G
D
S
G
L
----
V
A
I
S
L
R
D
A
I
N
S
G
K
---------
L
A
G
P
R
I
F
---
A
A
G
K
T
I
A
T
T
G
G
H
ADPTNGKAVDDYDYP
V
P
E
Q
G
V
V
N
-
G
P
Y
E
V
Y
A
A
V
R
Q
R
Y
K
D
G
---
A
-----
D
G
I
K
I
T
V
T
G
G
V
LSVAKSGQ
N
P
QF
T
------
Q
E
E
-
V
D
A
V
V
S
A
A
K
D
Y
G
M
W
V
A
V
-
H
A
H
G
-
A
E
G
M
K
R
A
I
K
-
A
G
V
D
S
--
I
E
H
G
T
F
-
M
D
L
----------------
E
A
M
D
L
M
I
E
N
G
T
Y
Y
V
P
T
I
S
A
G
E
F
V
A
E
K
S
K
IDNF
F
P
E
I
V
----
R
P
K
A
A
---
S
V
----
G
P
Q
I
S
D
T
F
R
K
A
Y
E
K
G
V
----
K
I
----
A
F
G
T
D
A
G
V
---
Q
K
-
H
G
T
N
W
K
E
F
V
Y
M
V
E
---------------
N
-----
G
M
P
A
M
K
A
I
Q
S
A
T
M
E
T
A
K
L
L
R
I
E
D
K
L
G
S
I
E
S
G
K
L
A
D
L
I
A
V
K
G
N
----------
P
IEDISVLE--------------
N
V
D
V
V
I
K
D
G
L
L
Y
E
G
-
77
HHSearch
64.37
15%
-60
- C1 -
2I9U
3
?
A:
[10-427]
-
L
K
I
F
K
G
N
L
I
-
F
T
K
T
-
S
D
K
F
T
I
M
K
D
S
Y
I
V
V
I
D
G
K
I
A
S
V
S
S
N
L
---
P
DKY
K
G
-------
N
P
I
I
D
F
R
N
N
I
I
I
P
G
M
N
D
L
H
A
H
A
S
Q
Y
K
--
N
LGIGMDKE
L
L
P
W
--------
L
N
N
Y
T
F
P
E
E
A
K
F-
L
-
N
----
V
D
-----
Y
A
K
K
T
Y
-
G
R
L
I
K
D
L
I
K
N
G
T
T
R
V
A
L
F
A
T
L
H
-----
K
-
D
S
T
I
E
L
F
N
M
L
I
K
---------
S
G
I
G
A
Y
---
V
G
K
V
N
M
D
Y
N
C
P
D
---------------
Y
L
T
E
N
Y
I
---
T
--
S
L
N
D
T
E
E
I
I
L
K
Y
KDK
S
-----
N
I
V
K
P
-
I
I
-----------
T
P
--
R
FVPSCS
N
E
L
-
M
D
G
L
G
K
L
S
Y
K
Y
R
L
P
V
Q
S
-
H
L
S
E
N
L
D
E
I
A
V
V
K
S
L
H
K
K
S
N
F
Y
G
E
V
Y
D
---------
K
F
G
L
F
G
N
-------
T
P
T
L
M
A
H
C
I
H
S
S
K
E
E
I
N
--
L
I
K
R
-
N
N
----
V
T
I
V
H
----
C
P
T
S
N
F
N
L
G
S
G
M
M
-------
P
V
R
K
Y
L
N
L
G
I
----
N
V
----
V
L
G
S
D
I
S
A
---
G
H
-
T
C
S
L
F
K
V
I
A
Y
A
I
Q
--
N
S
K
I
K
W
Q
E
S
G
KKD
M
-----
F
L
S
T
S
E
A
F
Y
M
A
T
K
K
G
G
S
F
F
G
---
K
V
G
S
F
E
E
G
Y
D
F
D
A
L
V
I
N
D
S
----------
N
LYPEDYD
L
T
E
R
L
E
R
F
I
Y
LGDDR
N
I
M
K
R
Y
V
C
G
N
E
I
F
--