@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0258: (2015-11-29 )
MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNVQELYLKSLELLGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLQTGPVTSEVTYGLERLASYIQEVDSVYDIEWAPGVKYGEIFTQPEYEHSKYSFEISDQVMLLENFEKFEREAKRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYITRIRNLARVVAKTFVAERKKLGFPLLDEETRIKLLAEED
Atome Classification :
(20 SA)
---.........10........20----.........30.---------....--.----..40-......---..50.-.......60..----..----.-...70--........-.80...-----...-.------..-90........100---...--..-----------..-------------------------110..---------....-.120....-------..---------------.130------....------.-------------------...140-----.---..-------...-----------..-150------.-------.--------------....---...160.---...--....170------.......180------------.-...----.----..------..--190....--------------...200......--------..210....----.-.-----------.220.......-----230.......240....--..-----.250.-.-.....260-......--..-270.....--..280.......290-------.--------------.-..------....300.-.---------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MSKKL
T
F
Q
E
I
I
L
T
L
Q
Q
F
WND-----QG
C
M
L
M
Q
AYDNE---------KGAG--T----M
S
P
Y
-
T
F
L
R
AI---GPEPW-NAAYVEPSRRP----AD----G-RYGE---
N
P
N
R
L
Y
Q
H
-
H
Q
-
F
Q
V
-----
V
MK-P------SP-S
N
V
Q
E
L
Y
L
K
S
L
E
L
---LGI--NP-----------
L
E
-------------------------
H
D
I
R
F
---------
V
EDN-WENPSTGS-------AG---------------L
G
W
-------
E
V
W
L------D-------------------G
M
E
IT------
Q
---
F
T
-------
Y
F
Q
-----------
Q
V-G--------G-------L--------------QTGP---
V
T
S
E
V
-
T
---
Y
G
L
--
E
R
L
A
S
Y
I
------
Q
E
V
D
SVYD--------------I-EWA----P----GV------KY--GEIFTQP--------------EYEH-S
K
Y
S
F
EI--------SD
Q
V
M
L
L
E
N
----
F
-
E
-----------
K
F
E
R
E
A
K
R
A
L
E
-----EGLVH
P
A
Y
D
Y
V
LKCS
H
T
--
F
N
-----LLDAR-G-
A
V
S
V
T
E
R--A
G
Y
I
T
R
--
I
R
-
N
L
A
R
V
V
A
K
--
T
F
V
A
E
R
K
KLGFPLL--------D--------------E-E
T
------
R
I
K
L
L
AEE-D---------------------------------------------------
2
PsiBlast_PDB
99.17
59%
-79
- C6 -
3RGL
2
SYGA_CAMJE
A:
[22-303]
----
S
N
A
M
T
F
S
Q
M
I
L
N
L
Q
N
Y
W
Q
E
-----
Q
G
C
A
I
M
Q
P
Y
D
M
P
---------
A
G
A
G
--
T
----
F
H
P
A
-
T
F
L
R
S
L
---
G
K
K
P
W
-
A
A
A
Y
V
A
P
S
R
R
P
----
T
D
----
G
-
R
Y
G
E
---
N
P
N
R
L
G
A
Y
-
Y
Q
-
F
Q
V
-----
L
I
K
-
P
------
S
P
-
D
N
I
Q
E
L
Y
L
K
S
L
E
N
---
L
G
F
--
D
L
-----------
K
S
-------------------------
H
D
I
R
F
---------
V
E
D
N
-
W
E
S
P
S
L
G
A
-------
W
G
---------------
L
G
W
-------
E
V
W
L
------
D
-------------------
G
M
E
V
T
------
Q
---
F
T
-------
Y
F
Q
-----------
Q
V
-
G
--------
G
-------
I
--------------
A
V
D
L
---
V
S
A
E
I
-
T
---
Y
G
L
--
E
R
I
A
M
Y
L
------
Q
N
V
D
N
V
Y
D
--------------
I
-
V
W
S
EFNG
E
----
K
I
------
K
Y
--
A
D
V
H
K
Q
S
--------------
E
Y
E
F
-
S
K
Y
N
F
E
V
--------
S
D
V
K
I
L
N
E
Q
----
F
-
E
-----------
N
S
Y
K
E
C
K
N
I
L
E
-----
Q
G
L
A
L
P
A
Y
D
Y
C
M
L
A
A
H
T
--
F
N
-----
L
L
D
A
R
-
G
-
A
I
S
V
A
Q
R
--
Q
D
Y
M
L
K
--
I
R
-
E
L
S
K
N
C
A
E
--
I
Y
K
K
N
L
N
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.13
59%
-76
- C6 -
3RF1
4
SYGA_CAMJJ
A:
[22-303]
----
S
N
A
M
T
F
S
Q
M
I
L
N
L
Q
N
Y
W
Q
E
-----
Q
G
C
A
I
M
Q
P
Y
D
M
P
---------
A
G
A
G
--
T
----
F
H
P
A
-
T
F
L
R
S
L
---
G
K
K
P
W
-
A
A
A
Y
V
A
P
S
R
R
P
----
T
D
----
G
-
R
Y
G
E
---
N
P
N
R
L
G
A
Y
-
Y
Q
-
F
Q
V
-----
L
I
K
-
P
------
S
P
-
D
N
I
Q
E
L
Y
L
K
S
L
E
N
---
L
G
F
--
D
L
-----------
K
S
-------------------------
H
D
I
R
F
---------
V
E
D
N
-
W
E
S
P
S
L
G
A
-------
W
G
---------------
L
G
W
-------
E
V
W
L
------
D
-------------------
G
M
E
V
T
------
Q
---
F
T
-------
Y
F
Q
-----------
Q
V
-
G
--------
G
-------
I
--------------
A
V
D
L
---
V
S
A
E
I
-
T
---
Y
G
L
--
E
R
I
A
M
Y
L
------
Q
N
V
D
N
V
Y
D
--------------
I
-
V
W
S
EFNG
E
----
K
I
------
K
Y
--
A
D
V
H
K
Q
S
--------------
E
Y
E
F
-
S
K
Y
N
F
E
V
--------
S
D
V
K
I
L
N
E
Q
----
F
-
E
-----------
N
S
Y
K
E
C
K
N
I
L
E
-----
Q
G
L
A
L
P
A
Y
D
Y
C
M
L
A
A
H
T
--
F
N
-----
L
L
D
A
R
-
G
-
A
I
S
V
A
Q
R
--
Q
D
Y
M
L
K
--
I
R
-
E
L
S
K
N
C
A
E
--
I
Y
K
K
N
L
N
-----------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
98.04
59%
-78
- C6 -
3UFG
1
SYGA_CAMJE
A:
[22-303]
----
S
N
A
M
T
F
S
Q
M
I
L
N
L
Q
N
Y
W
Q
E
-----
Q
G
C
A
I
M
Q
P
Y
D
M
P
---------
A
G
A
G
--
T
----
F
H
P
A
-
T
F
L
R
S
L
---
G
K
K
P
W
-
A
A
A
Y
V
A
P
S
R
R
P
----
T
D
----
G
-
R
Y
G
E
---
N
P
N
R
L
G
A
Y
-
Y
Q
-
F
Q
V
-----
L
I
K
-
P
------
S
P
-
D
N
I
Q
E
L
Y
L
K
S
L
E
N
---
L
G
F
--
D
L
-----------
K
S
-------------------------
H
D
I
R
F
---------
V
E
D
N
-
W
E
S
P
S
L
G
A
-------
W
G
---------------
L
G
W
-------
E
V
W
L
------
D
-------------------
G
M
E
V
T
------
Q
---
F
T
-------
Y
F
Q
-----------
Q
V
-
G
--------
G
-------
I
--------------
A
V
D
L
---
V
S
A
E
I
-
T
---
Y
G
L
--
E
R
I
A
M
Y
L
------
Q
N
V
D
N
V
Y
D
--------------
I
-
V
W
S
EFNG
E
----
K
I
------
K
Y
--
A
D
V
H
K
Q
S
--------------
E
Y
E
F
-
S
K
Y
N
F
E
V
--------
S
D
V
K
I
L
N
E
Q
----
F
-
E
-----------
N
S
Y
K
E
C
K
N
I
L
E
-----
Q
G
L
A
L
P
A
Y
D
Y
C
M
L
A
A
H
T
--
F
N
-----
L
L
D
A
R
-
G
-
A
I
S
V
A
Q
R
--
Q
D
Y
M
L
K
--
I
R
-
E
L
S
K
N
C
A
E
--
I
Y
K
K
N
L
N
-----------------------------------------------------------------------------------------------------
12
HHSearch
96.18
56%
-74
- C6 -
3RF1
4
SYGA_CAMJJ
A:
[21-308]
---
Q
S
N
A
M
T
F
S
Q
M
I
L
N
L
Q
N
Y
W
Q
E
-----
Q
G
C
A
I
M
Q
P
Y
D
M
P
---------
A
G
A
G
TF
H
----
P
A
T
F
-
L
-
R
S
-
L
---
G
K
K
P
W
-
A
A
A
Y
V
A
P
S
R
R
P
----
T
D
----
G
-
R
Y
G
E
N--
P
N
R
-
L
G
A
Y
-
Y
Q
-
F
Q
V
-----
L
I
K
-
P
------
S
P
-
D
N
I
Q
E
L
Y
L
K
S
L
E
N
---
L
G
F
--
D
L
-----------
K
S
-------------------------
H
D
I
R
F
---------
V
E
D
N
-
W
E
S
P
S
L
G
A
-------
W
G
---------------
L
G
W
-------
E
V
W
L
------
D
-------------------
G
M
E
V
T
------
Q
---
F
T
-------
Y
F
Q
-----------
Q
V
-
G
--------
G
-------
I
--------------
A
V
D
L
---
V
S
A
E
I
-
T
---
Y
G
L
--
E
R
I
A
M
Y
L
------
Q
N
V
D
N
V
Y
D
--------------
I
-
V
W
S
----
E
FNG
E
K
I
------
K
Y
--
A
D
V
H
K
Q
S
--------------
E
Y
E
F
-
S
K
Y
N
F
E
V
--------
S
D
V
K
I
L
N
E
Q
----
F
-
E
-----------
N
S
Y
K
E
C
K
N
I
L
E
-----
Q
G
L
A
L
P
A
Y
D
Y
C
M
L
A
A
H
T
--
F
N
-----
L
L
D
A
R
-
G
-
A
I
S
V
A
Q
R
--
Q
D
Y
M
L
K
--
I
R
-
E
L
S
K
N
C
A
E
--
I
Y
K
K
N
L
N
-----------------------------------------------------------------------------------------------------
15
HHSearch
60.84
19%
-43
- C6 -
1YFS
1
SYA_AQUAE
A:
[2-308]
------
S
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
-----
K
G
H
T
R
V
K
S
A
P
L
V
PENDPTLLF
V
N
A
G
MV
P
----
F
K
N
V
-
F
-
L
G
L
E
---
K
R
P
Y
K
-
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
LEQV
G
-
Y
T
S
R
HHT
F
F
E
-
M
L
G
N
-
F
S
-
F
G
D
-----
Y
F
K
-
K
------
E
A
-
I
E
Y
A
W
---
E
F
V
T
E
V--
L
K
L
--
P
K
-----------
E
K
L
Y
V
S
V
YKDD
E
E
A
Y
R
I
W
N
EHIGIPSE
R
I
W
R
L
G
E-------
E
D
N
F
-
W
Q
M
G
D
V
G
P
-------
C
G
---------------
P
S
S
-------
E
I
Y
V
------
D
RGEEYEGDER---------
Y
L
E
I
W
------
N
---
L
V
-------
F
M
Q
Y
N
---------
R
D
-
E
--------
N
-------
G
--------------
V
L
T
P
L
P
H
P
N
I
D
T
-
G
---
M
G
L
--
E
R
I
A
S
V
L
------
Q
G
K
N
S
N
F
E
--------------
I
D
I
I
F
----
P
----
L
I
------
Q
F
--
G
--
E
------------------
E
V
S
G
K
K
Y
G
-------------------------------------------------------
E
K
F
E
T
D
V
A
L
R
V
I
A
D
H
L
R
A
I
T
-----
F
A
I
S
D
-
G
-
V
I
P
S
N
E
G
--
R
G
Y
V
I
R
R
I
L
R
-
R
A
M
R
F
G
Y
K
--
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
--------
V
--------------
V
-
D
I
------
M
K
E
P
Y
P
E
L
-
E
---------------------------------------------------
14
HHSearch
60.14
23%
-30
- C6 -
3WQY
1
SYA_ARCFU
A:
[57-378]
----
K
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
-----
R
G
H
G
R
I
E
R
Y
P
V
V
ARWRTDIYL
T
I
A
S
I
A
D
----
F
Q
P
F
-
V
-
T
S
G
V
---
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
LDSV
G
-
R
T
G
R
HLT
L
F
E
-
M
M
A
H
-
H
A
-
F
N
Y
PGKEI
Y
W
K
-
N
------
E
T
-
V
A
Y
C
T
---
E
L
L
N
E
---
L
G
V
--
K
K
-----------
E
---------------------------
D
I
V
Y
---------
K
E
E
P
-
W
A
G
--
G
G
N
-------
A
G
---------------
P
C
L
-------
E
A
I
V
------
G
-------------------
G
L
E
V
A
------
T
---
L
V
-------
F
M
N
L
E
---------
E
H
-
P
--------
E
GDIEIKG
A
--------------
R
Y
R
K
M
D
N
Y
I
V
D
T
-
G
---
Y
G
L
--
E
R
F
V
W
A
S
------
K
G
T
P
T
V
Y
D
--------------
A
-
I
F
P
----
E
----
V
V
------
D
T
--
I
--
I
D
N
S
NVSFNRED
E
R
V
R
R
I
V
A
E
S
-
S
K
L
A
-
G
I
--------
M
G
E
L
R
G
E
R
L
----
N
-
Q
-----------
L
R
K
S
V
A
D
T
V
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
-----
F
M
L
G
D
-
G
-
L
V
P
S
N
A
G
--
A
G
Y
L
A
R
L
M
I
R
-
R
S
L
R
L
A
E
E
--
L
E
L
G
L
D
L
Y
D
L
V
E
M
H
--------
K
--------------
K
-
I
L
------
G
F
E
F
D
V
P
L
-
S
---------------------------------------------------
16
HHSearch
59.94
23%
-27
- C6 -
2ZTG
1
SYA_ARCFU
A:
[57-378]
----
K
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
-----
R
G
H
G
R
I
E
R
Y
P
V
V
ARWRTDIYL
T
I
A
S
I
A
D
----
F
Q
P
F
-
V
-
T
S
G
V
---
A
P
P
P
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
LDSV
G
-
R
T
G
R
HLT
L
F
E
-
M
M
A
H
-
H
A
-
F
N
Y
PGKEI
Y
W
K
-
N
------
E
T
-
V
A
Y
C
T
---
E
L
L
N
E
---
L
G
V
--
K
K
-----------
E
---------------------------
D
I
V
Y
---------
K
E
E
P
-
W
A
G
--
G
G
N
-------
A
G
---------------
P
C
L
-------
E
A
I
V
------
G
-------------------
G
L
E
V
A
------
T
---
L
V
-------
F
M
N
LE---------
E
H
-
P
--------
E
-------
G
DIEIKG
A
-------
R
Y
R
K
MDN
Y
I
V
D
T
-
G
---
Y
G
L
--
E
R
F
V
W
A
S
------
K
G
T
P
T
V
Y
D
--------------
A
-
I
F
P
----
E
----
V
V
------
D
T
--
I
--
I
D
N
S
NVSFNRED
E
R
V
R
R
I
V
A
E
S
-
S
K
L
A
-
G
I
--------
M
G
E
L
R
G
E
R
L
----
N
-
Q
-----------
L
R
K
S
V
A
D
T
V
G
V
S
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
-----
F
M
L
G
D
-
G
-
L
V
P
S
N
A
G
--
A
G
Y
L
A
R
L
M
I
R
-
R
S
L
R
L
A
E
E
--
L
E
L
G
L
D
L
Y
D
L
V
E
M
H
--------
K
--------------
K
-
I
L
------
G
F
E
F
D
V
P
L
-
S
---------------------------------------------------
17
HHSearch
59.77
21%
-40
- C6 -
3HY0
4
SYA_ECOLI
A:
[2-321]
-------
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
-----
K
G
H
Q
V
V
A
S
S
S
L
V
PHNDPTLLF
T
N
A
G
MN
Q
----
F
K
D
V
-
F
-
L
G
L
D
---
K
R
N
Y
S
-
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
LENV
G
-
Y
T
A
R
HHT
F
F
E
-
M
L
G
N
-
F
S
-
F
G
D
-----
Y
F
K
-
L
------
D
A
-
I
L
F
A
W
---
L
L
L
T
S
EKW
F
A
L
--
P
K
-----------
E
R
L
W
V
T
V
YESD
D
E
A
Y
E
I
W
E
KEVGIPRE
R
I
I
R
I
G
DNKGAPYA
S
D
N
F
-
W
Q
M
G
D
T
G
P
-------
C
G
---------------
P
C
T
-------
E
I
F
Y
------
D
HGDH
I
W
G
G
P
P
GSPEEDGDR
Y
I
E
I
W
------
N
---
I
V
-------
F
M
Q
F
N
---------
R
Q
-
A
--------
D
-------
G
--------------
T
M
E
P
L
P
K
P
S
V
D
T
-
A
---
M
G
L
--
E
R
I
A
A
V
L
------
Q
H
V
N
S
N
Y
D
--------------
I
D
L
F
R
----
T
----
L
I
------
Q
A
--
V
--
A
------------------
K
V
T
-
G
----------------
A
------------------------------------------
T
D
L
S
N
K
S
L
R
V
I
A
D
H
I
R
S
C
A
-----
F
L
I
A
D
-
G
-
V
M
P
S
N
E
N
--
R
G
Y
V
L
R
R
I
I
R
-
R
A
V
R
H
G
N
M
--
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
--------
L
--------------
I
-
D
V
------
M
G
S
A
G
E
D
L
-
K
---------------------------------------------------
4
PsiBlast_PDB
47.65
26%
-87
- C6 -
2ZZF
-
SYA_PYRHO
A:
[147-268]
------------------------------------------------------------------------------------------------------------------
M
M
A
H
-
H
A
-
F
N
Y
-----
P
G
K
-
P
IYW
M
D
E
T
V
-
E
L
A
F
E
F
F
T
K
E
L
K
M
--------
K
P
--------------------------------------
E
D
I
T
F
---------
K
E
N
P
-
W
--
A
G
G
G
N
-------
A
G
---------------
P
A
F
-------
E
V
L
Y
------
R
-------------------
G
L
E
V
A
------
T
---
L
V
-------
F
M
Q
Y
KK-------------------------------------------
K
Y
I
P
---
M
E
T
K
V
-
V
D
T
G
Y
G
L
--
E
R
L
V
W
M
S
------
Q
G
T
P
T
A
Y
D
--------------
A
-
V
L
G
----
Y
----
V
V
------
E
P
--
L
K
K
M
A
G
I
--------------
E
K
I
D
-
E
K
I
L
M
E
N
--------
S
R
L
A
G
M
F
D
I
----
E
-
D
-----------
L
G
D
L
R
Y
L
R
E
Q
V
-----
A
K
R
V
G
I
T
V
E
E
L
E
K
A
I
R
P
--
Y
E
-----
L
I
Y
A
I
-
A
-
D
H
T
K
A
L
T
--
F
M
L
A
D
G
--
V
V
-
P
S
N
V
K
A
G
Y
--
L
A
R
L
L
I
R
K
S
I
R
H
L
R
--------
E
--------------
L
-
G
L
------
E
V
P
L
S
E
I
V
-
A
---------------------------------------------------
5
PsiBlast_PDB
46.68
26%
-77
- C6 -
2ZZG
1
SYA_PYRHO
A:
[147-268]
------------------------------------------------------------------------------------------------------------------
M
M
A
H
-
H
A
-
F
N
Y
-----
P
G
K
-
P
IYW
M
D
E
T
V
-
E
L
A
F
E
F
F
T
K
E
L
K
M
--------
K
P
--------------------------------------
E
D
I
T
F
---------
K
E
N
P
-
W
--
A
G
G
G
N
-------
A
G
---------------
P
A
F
-------
E
V
L
Y
------
R
-------------------
G
L
E
V
A
------
T
---
L
V
-------
F
M
Q
Y
K
K
A
PEQDQ
V
V
V
I
-
K
--------
G
-------
E
--------------
K
Y
I
P
---
M
E
T
K
V
-
V
D
T
G
Y
G
L
--
E
R
L
V
W
M
S
------
Q
G
T
P
T
A
Y
D
--------------
A
-
V
L
G
----
Y
----
V
V
------
E
P
--
L
K
K
M
A
G
I
--------------
E
K
I
D
-
E
K
I
L
M
E
N
--------
S
R
L
A
G
M
F
D
I
----
E
-
D
-----------
L
R
Y
L
R
E
Q
V
A
K
R
-----
V
G
I
T
V
E
E
L
E
K
A
I
R
P
Y
E
L
--
I
Y
-----
A
I
A
D
H
-
T
-
K
A
L
T
F
M
L
--
A
D
G
V
V
P
--
S
N
-
V
K
A
G
Y
L
A
R
--
L
L
I
R
K
S
I
R
H
L
R
E
L
G
--------
L
--------------
E
-
V
P
------
L
S
E
I
V
A
L
H
-
I
---------------------------------------------------
36
Fugue
44.09
14%
-30
- C3 -
2BAS
1
YKUI_BACSU
A:
[26-431]
LD
P
L
D
I
L
T
N
I
D
D
V
L
P
Y
Y
Q
A
I
F
S
A
EEQKV
V
G
Y
E
V
L
G
R
I
L
A
D
----------
S
E
I
--
Q
----
S
L
G
P
-
F
F
L
D
A
G
---
I
P
E
E
Y
-
K
L
E
V
D
N
R
I
I
R
Q
----
A
L
----
D
-
R
F
L
E
---
A
D
S
D
L
L
I
F
M
N
Q
-
D
A
N
-----
L
L
-
M
L
------
D
H
-
G
E
S
F
L
E
L
L
K
E
Y
E
A
---
K
G
I
--
E
L
-----------
H
R
-------------------------
F
V
L
E
I
---------
T
E
H
N
-
F
E
G
D
I
E
Q
L
Y
H
M
L
A
Y
Y
R
T
---------------
Y
G
I
-------
K
I
A
V
------
D
NI-----------------
G
K
E
S
S
------
N
---
L
D
-------
R
I
A
-----------
L
L
-
S
PD
L
L
K
I
D
L
Q
-------
A
--------------
L
K
S
P
---
S
Y
E
H
V
-
L
---
Y
S
I
--
S
L
L
A
R
K
I
G
A
A
L
L
Y
E
D
I
E
A
N
F
Q
--------------
L
-
Q
Y
A
----
W
R
N
--
G
G
------
R
Y
FQ
G
Y
Y
L
V
S
P
SE------------
T
F
L
E
-
R
D
V
L
K
Q
R
--------
L
K
T
E
F
H
Q
F
I
----
T
-
H
-----------
E
K
K
K
L
E
T
V
Y
E
H
-----
S
E
Q
F
Y
K
R
V
H
Q
A
V
T
S
L
R
K
--
N
N
-----
L
S
S
D
D
-
D
-
F
I
K
K
L
A
E
E
L
T
D
C
S
F
R
--
I
Y
M
C
D
E
E
G
D
Q
L
--
T
G
N
V
F
K
Q
D
G
E
W
I
Y
Q
--------
P
--------------
E
-
Y
A
EKNWSW
R
P
Y
F
L
E
N
I
M
R
M
R
N
L
R
K
G
F
F
S
D
LYSDLETG
E
M
I
R
T
F
S
Y
P
M
D
DQ
M
Y
L
F
I
D
L
P
Y
S
Y
L
Y
E
QDGLI
42
Fugue
41.35
17%
-13
- C5 -
3R6O
4
?
A:
[22-323]
---
M
N
---------
L
R
I
V
S
F
A
W
Q
-----
P
G
V
L
I
D
D
D
T
V
A
P
--------------------
L
A
P
M
-
S
A
R
E
L
I
---
A
L
L
P
Q
-
I
S
P
L
I
S
D
E
L
V
P
----
L
D
----
S
-
V
A
L
G
---
A
P
--
I
P
E
P
-
G
Q
-
V
I
A
-----
L
G
F
-
N
------
Y
P
-
T
H
D
P
V
V
F
M
K
S
-------------------------
P
-------------------------
T
S
I
S
G
---------
P
R
D
A
-
V
I
A
P
R
T
-
S
-------
H
A
---------------
L
D
Y
-------
E
I
E
I
A
V
V
I
G
K
P
-------------------
G
Y
R
I
E
------
R
---
S
Q
-------
A
I
K
-----------
H
V
-
A
--------
G
-------
Y
--------------
M
L
A
N
---
D
I
T
A
R
-
D
---
V
A
L
--
P
F
G
Q
A
Q
V
------
V
R
G
K
G
Y
P
T
-----------------
F
C
----
P
T
---
G
P
------
W
L
--
F
T
T
G
S
D
T
--------------
T
F
E
T
-
F
D
F
E
L
R
I
--------
N
G
E
L
R
Q
S
G
S
----
T
-
V
-----------
D
-----------------
M
T
L
G
F
A
E
V
V
E
T
V
S
A
T
--
I
A
-----
L
--
R
A
-
G
-
D
I
I
L
T
G
T
--
P
G
G
C
G
F
--
Q
F
-
D
P
P
R
Y
L
R
P
G
D
V
I
E
A
H
S
A
K
L
G
-----------------------------
K
M
------
R
L
P
V
H
D
E
K
-
P
---------------------------------------------------
43
Fugue
38.36
14%
-24
- C4 -
3ZPJ
-
?
A:
[1-356]
------
M
T
T
L
E
E
I
N
L
L
V
E
R
G
Y
Y
E
-----
E
A
L
A
K
V
Y
E
I
E
D
P
---------
I
E
Q
V
--
Q
----
V
L
T
K
-
I
V
V
T
I
Y
Q
H
D
G
P
M
E
W
-
I
P
S
I
M
E
D
A
M
Y
I
----
A
K
----
K
L
R
D
P
A
---
N
K
A
V
A
Y
S
I
-
I
A
-
S
T
L
-----
A
I
M
-
E
------
Y
E
-
E
D
A
M
D
F
F
N
R
A
I
D
E
---
A
N
E
IE
S
P
-----------
I
E
-------------------------
K
G
M
V
L
---------
S
T
L
A
-
Y
H
L
A
I
A
G
Y
-------
P
D
---------------
N
A
L
-------
E
I
F
N
------
I
-------------------
A
F
D
T
I
------
I
G
AE
T
S
-------
Y
T
H
-----------
K
V
-
D
--------
G
I
------
L
--------------
R
I
G
D
---
L
L
E
K
A
-
G
---
D
T
L
PS
N
E
A
M
D
F
Y
------
K
M
A
F
D
I
F
D
K
L
HV
N
Q
R
A
A
I
V
E
K
K
I
-
E
L
A
----
K
----
T
V
YDVGL
P
Q
I
--
R
A
A
L
L
K
G
--------------
K
N
H
Y
-
A
L
A
I
I
K
K
K
Y------
S
G
V
M
R
L
I
G
E
----
L
-
E
V
A
L
W
M
K
R
V
NNM
E
Y
L
D
V
V
D
K
A
F
E
-------
C
C
E
S
P
R
F
T
D
V
N
V
Q
H
I
--
A
R
-----
L
L
T
E
L
-
G
N
L
R
R
A
L
K
F
--
A
K
E
I
Q
N
--
I
H
-
K
R
S
E
A
L
K
A
--
I
A
L
E
L
V
R
R
K
K
F
E
E
V
K
K
I
I
E
S
IP
D
--------------
P
-
K
I
------
R
E
E
A
L
N
E
I
-
G
TIE------------------------------------------------
41
Fugue
38.18
16%
-32
- C2 -
2Y23
4
A:
[6-312]
---------
T
K
E
V
V
V
N
V
----
D
D
-----
D
G
V
I
S
L
N
F
E
C
D
K
---------
M
T
P
K
--------
S
E
F
-
S
W
S
K
---------------------------
D
----
Y
-
V
S
T
E
---
D
S
P
R
L
E
V
E
-
S
K
G
N
K
T
-----
K
M
T
-
F
------
K
D
-
L
G
M
D
D
L
G
I
Y
S
C
D
V
---
T
D
T
--
D
G
-----------
I
A
-------------------------
S
S
Y
L
I
---------
D
E
E
E
-
L
K
R
L
L
A
L
S
-------
H
E
---------------
H
K
F
PTVPVKS
E
L
A
V
------
E
-------------------
I
L
E
K
G
------
Q
---
V
R
-------
F
W
M
-----------
Q
A
-
E
--------
K
-------
L
--------------
S
G
N
A
---
K
V
N
Y
I
-
F
---
N
E
K
--
E
I
F
----------
E
G
P
K
Y
K
M
H
--------------
I
-
D
R
N
----
T
----
G
I
------
I
E
--
M
F
M
E
K
L
Q
--------------
D
E
D
E
-
G
T
Y
T
F
Q
L
Q
D
G
K
A
T
N
H
S
T
V
V
L
V
G
D
V
----
F
-
K
-----------
K
L
Q
K
E
A
E
F
Q
R
Q
-----
E
W
I
R
K
Q
G
P
H
F
V
E
Y
L
S
W
E
--
V
T
G
EC
N
V
L
L
K
C
K
-
V
-
A
N
I
K
K
E
T
--
H
I
V
W
Y
K
--
D
E
-
R
E
I
S
V
D
E
K
--
H
G
I
C
T
L
L
I
T
E
F
S
K
K
--------
D
A
G
I
Y
E
V
I
L
KDDR
G
K
D
-
K
S
------
R
L
K
L
V
D
E
A
-----------------------------------------------------
25
HHSearch
32.20
19%
-8
- C6 -
1N9W
-
SYDND_THET8
A:
[333-414]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
---------------
R
S
F
-------
D
L
L
F
------
R
-------------------
G
L
E
I
T
------
S
---
G
G
QRIHR--
Y
E
E
L
L
E
--------
S
L
K
A
--------
K
-------
G
MDPEAFHGYL
E
V
F
K
Y
G
M
P
---
P
H
G
G
F
-
A
---
I
G
A
--
E
R
L
T
Q
K
L
------
L
G
L
P
N
V
R
Y
--------------
A
R
A
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
31.85
17%
-5
* C5 *
4YD8
-
PTHB1_HUMAN
A:
[7-373]
---
L
F
K
A
R
D
W
W
S
T
I
L
G
D
K
E
E
F
-
D
-----
Q
G
C
L
C
L
A
N
V
D
N
----------
S
G
N
G
--
Q
D
K
I
I
V
G
S
F
M
G
Y
L
R
I
F
---
S
P
H
P
A
-
K
T
---
G
D
G
A
Q
A
----
E
D
----
L
-
L
L
E
V
---
D
L
R
D
P
V
L
Q
-
V
E
-
V
G
K
-----
F
V
S
-
G
------
T
E
M
L
H
L
A
V
L
H
S
R
K
L
C
V
---
Y
S
V
--
S
G
T
LGNQ
C
Q
M
K
L
M
Y
E
-------------------------
H
N
L
Q
R
---------
T
A
C
N
M
T
Y
G
S
F
G
G
V
-------
K
G
R
D
L
I
C
I
Q
S
MD
G
M
L
M
V
F
E
Q
-------
E
S
Y
A
------
F
-------------------
G
R
F
L
P
GFLLP
G
P
---
L
A
-------
Y
S
S
-----------
R
T
-
D
--------
S
-------
F
--------------
L
T
V
S
---
S
C
Q
Q
V
E
S
---
Y
K
Y
--
Q
V
L
A
F
A
T
------
D
A
D
K
L
V
V
D
--------------
W
-
T
L
N
----
I
----
G
E
------
Q
A
--
L
D
I
C
I
V
S
--------------
F
S
A
S
-
S
V
F
V
L
G
E
--------
R
N
F
F
C
L
K
D
N
GQIR
F
M
K
-----------
K
L
D
W
S
P
S
C
F
L
P
-----
Y
C
S
V
S
E
G
T
I
N
T
L
I
G
N
H
N
-------------
N
M
L
-
H
I
Y
Q
D
V
T
--
L
K
W
A
T
Q
--
L
P
-
H
I
P
V
A
V
R
V
--
G
C
L
H
D
L
K
G
V
I
V
T
L
S
--------
D
--------------
D
G
H
L
------
Q
C
S
Y
L
G
T
D
-
P
SLFQAP---------------------------------------------
9
PsiBlast_PDB
27.46
25%
4
- C6 -
4ICK
-
AP4A_HUMAN
A:
[54-138]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------
A
---
L
R
-------
A
T
Q
-----------
E
E
-
A
--------
G
-------
I
--------------
E
A
G
Q
---
L
T
--
I
-
I
---
E
G
F
--
K
R
E
L
N
Y
V
------
A
R
N
K
P
K
T
V
--------------
I
-
Y
W
L
----
A
----
E
V
------
K
D
--
Y
D
V
E
I
R
L
--------------
S
H
E
H
-
Q
A
Y
R
W
L
G
--------
L
E
E
A
C
Q
L
A
Q
----
F
----------------
K
E
M
K
A
A
L
Q
-----
E
G
H
Q
F
L
C
S
I
E
A
L
E
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
27.13
25%
1
- C6 -
4IJX
2
AP4A_HUMAN
A:
[54-138]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------
A
---
L
R
-------
A
T
Q
-----------
E
E
-
A
--------
G
-------
I
--------------
E
A
G
Q
---
L
T
--
I
-
I
---
E
G
F
--
K
R
E
L
N
Y
V
------
A
R
N
K
P
K
T
V
--------------
I
-
Y
W
L
----
A
----
E
V
------
K
D
--
Y
D
V
E
I
R
L
--------------
S
H
E
H
-
Q
A
Y
R
W
L
G
--------
L
E
E
A
C
Q
L
A
Q
----
F
----------------
K
E
M
K
A
A
L
Q
-----
E
G
H
Q
F
L
C
S
I
E
A
L
E
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
26.24
17%
-27
- C6 -
1WYD
2
SYDND_SULTO
A:
[340-422]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
---------------
E
S
F
-------
D
L
I
Y
------
K
-------------------
F
L
E
I
V
------
S
---
G
S
T
R
N
HK
R
E
V
L
E
E
----------
A
L
-
K
K
-------
K
-------
G
LKPESFEFFLKWFD
Y
G
M
P
---
P
H
A
G
F
-
G
---
M
G
L
--
A
R
L
M
V
M
L
------
T
G
I
Q
S
V
K
E
--------------
I
V
P
F
P
----
R
----
D
K
------
K
R
--
L
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
25.53
25%
0
- C6 -
1XSB
-
AP4A_HUMAN
A:
[59-143]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------
A
---
L
R
-------
A
T
Q
-----------
E
E
-
A
--------
G
-------
I
--------------
E
A
G
Q
---
L
T
--
I
-
I
---
E
G
F
--
K
R
E
L
N
Y
V
------
A
R
N
K
P
K
T
V
--------------
I
-
Y
W
L
----
A
----
E
V
------
K
D
--
Y
D
V
E
I
R
L
--------------
S
H
E
H
-
Q
A
Y
R
W
L
G
--------
L
E
E
A
C
Q
L
A
Q
----
F
----------------
K
E
M
K
A
A
L
Q
-----
E
G
H
Q
F
L
C
S
I
E
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------