@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0274: (2015-11-29 )
MTYIEILGQNAKKASQSVARLSTASKNEILRDLARNIVADTETILTENARDVAKAKDNGISEIMVDRLRLNKDRIQAIANGIYQVADLADPIGQVVSGYTNLDGLKILKKRVPLGVIAMIFESRPNVSVDAFSLAFKTGNAIILRGGKDAIFSNTALVNCMRQTLQDTGHNPDIVQLVEDTSHVVAEELMQATDYVDVLIPRGGAKLIQTVKEKSKIPVIETGVGNVHIYIDEFADLDMAAKIVINAKTQRPSVCNAAEGLVVHQAIAKGFLSQLEKMLKESNQSVEFRADEEALQLLENAVAASESDYATEFLDYIMSVKVVDSFEQAISWINKYSSHHSEAIITNNISRAEIFQDMVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYYINGTGQVRE
Atome Classification :
(20 SA)
--------------------------------------------------------.........10.....---.-..20---........30........40.....------...50........60........70.-.....-..80........90.-.--.......100-....-.....110.......120..-.....-..130.--......140.......150-......-.--.-160....----...170.......180--......-.190.......200-.........210--...-----.---....220.......230.......240.......250.-.......260.......270.....-----..280------.........290--------------..----------------------------------------------.----------------------------------------....--.300--------..---...-------...310...--------------------------------------....320.......330.......----340.......350....--...360.......370-.---------......380.......390.-......400.......410.....------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------M
T
Y
I
E
I
LGQ
N
A
K
K
A
S
Q
---
S
-
V
A
R
L---STA
S
K
N
E
I
L
R
D
L
A
R
N
I
VA
D
T
E
T
I
L
T
------E
N
A
R
D
V
A
KAKDN
G
I
S
E
I
M
V
D
R
L
RL
N
K
-
D
R
I
Q
A
-
I
A
N
G
I
Y
Q
V
A
D
L
A
D
-
P
-
I
--
G
Q
V
V
S
GYT---N
L
D
G
-
L
K
I
L
K
K
RV
P
L
G
V
I
A
M
I
--FE-SRPN
V
-
S
V
D
A
F
S
--
L
A
FKTG
N
A
I
I
L
RGGKDAI--FS
N
T
A
L
-
V
--
N
-
C
M
R
Q
T
L
Q
----DTGHNP
D
I
V
Q
L
V
ED
T
S
--
H
V
V
A
E
E
-
L
M
Q
AT
D
Y
V
D
V
L
I---PRG
G
A
K
L
I
Q
T
V
---
K
E
K-----S---KI
P
V
I
E
TGV
G
N
V
H
I
Y
IDEFADL
D
M
A
A
K
I
V
I
N
AKTQR-P-SVC
N
A
AE
G
L
V
V
H
Q
A
I
A
K
G
F
L
S
Q
L
E
K
-----
M
L
K
--------ESNQ
S
V
E
FRA
D
---------------
E
E
----------------------------------------------
A
----------------------------------------
L
Q
L
L
--
E
N
A
---------VA---ASE-------
S
D
Y
A
T
E
F
L
D
--------------------------------------
Y
I
M
S
V
K
V
V
D
S
F
E
Q
A
I
S
W
I
N
K
Y
SSH----HS
E
A
I
ITNNI
S
R
A
E
I
F
Q
--
D
M
V
D
A
A
A
V
Y
VNASTRF-T---------D
G
F
V
F
GLGAEIGI
S
T
Q
K
L
HA-RGPM
G
L
E
A
LTS
T
K
Y
Y
INGTGQVRE------
2
PsiBlast_PDB
96.28
45%
-96
- C2 -
4GHK
-
PROA_BURTA
A:
[6-423]
----------------------------------------------------------
Y
M
T
D
V
G
R
R
A
R
R
A
S
R
---
S
-
I
A
R
A
---
S
T
A
A
K
N
A
A
L
E
A
V
A
R
A
I
E
R
D
A
G
A
L
K
A
------
A
N
A
R
D
V
A
R
------
D
A
A
F
V
D
R
L
T
L
S
D
-
K
A
L
K
T
-
M
V
E
G
L
R
Q
V
A
T
L
P
D
-
P
-
I
--
G
E
M
S
N
L
K
Y
---
R
P
S
G
-
I
Q
V
G
Q
M
R
V
P
L
G
V
I
G
I
I
--
Y
E
-
S
R
P
N
V
-
T
I
D
A
A
A
--
L
C
L
K
S
G
N
A
T
I
L
R
G
G
S
E
A
L
--
E
S
N
T
A
L
-
A
--
K
-
L
I
G
E
G
L
A
----
E
A
G
L
P
Q
D
T
V
Q
V
V
E
T
A
D
--
R
A
A
V
G
R
-
L
I
T
M
T
E
Y
V
D
V
I
V
---
P
R
G
G
K
S
L
I
E
R
L
---
I
N
E
-----
A
---
R
V
P
M
I
K
H
L
D
G
I
C
H
V
Y
V
D
D
R
A
S
V
T
K
A
L
T
V
C
D
-----------
C
N
T
M
E
T
L
L
V
A
R
G
I
A
P
A
V
L
S
P
L
G
R
-----
L
Y
R
--------
E
--
K
G
V
E
L
R
V
D
---------------
A
D
----------------------------------------------
A
----------------------------------------
R
A
V
L
--
E
A
A
GVGPL----
V
D
---
A
T
D
-------
E
D
W
R
T
E
-----------------------------------------
P
V
L
A
I
K
I
V
D
G
I
D
A
A
I
E
H
I
N
E
Y
G
S
H
----
H
T
D
A
I
V
T
E
D
H
D
R
A
M
R
F
L
--
R
E
V
D
S
A
S
V
M
V
N
A
S
T
R
F
-
A
---------
D
G
F
E
F
G
L
G
A
E
I
G
I
S
N
D
K
L
H
A
-
R
G
P
V
G
L
E
G
L
T
S
L
K
Y
V
V
L
G
H
G
E
G
R
Q
------
3
PsiBlast_PDB
82.28
37%
-91
- C2 -
1VLU
1
PROA_YEAST
A:
[19-443]
--------------------------------------------------------------
I
A
K
N
A
R
K
A
G
N
---
I
-
L
K
T
I
---
S
N
E
G
R
S
D
I
L
Y
K
I
H
D
A
L
K
A
N
A
H
A
I
E
E
------
A
N
K
I
D
L
A
V
A
K
E
T
G
L
A
D
S
L
L
K
R
L
D
L
F
K
G
D
K
F
E
V
-
M
L
Q
G
I
K
D
V
A
E
L
E
D
-
P
-
V
--
G
K
V
K
M
A
R
E
---
L
D
D
G
-
L
T
L
Y
Q
V
T
A
P
V
G
V
L
L
V
I
--
F
E
-
S
R
P
E
V
-
I
A
N
I
T
A
--
L
S
I
K
S
G
N
A
A
I
L
K
G
G
K
E
S
V
N
T
F
R
E
M
A
K
-
I
V
N
D
-
T
I
A
Q
F
Q
S
----
E
T
G
V
P
V
G
S
V
Q
L
I
E
T
R
----
V
--
S
D
-
L
L
D
Q
D
E
Y
I
D
L
V
V
---
P
R
G
S
N
A
L
V
R
K
I
---
K
D
T
-----
T
---
K
I
P
V
L
G
H
A
D
G
I
C
S
I
Y
L
D
E
D
A
D
L
I
K
A
K
R
I
S
L
D
A
K
T
N
------
C
N
A
M
E
T
L
L
I
N
P
K
F
S
K
-
W
W
E
V
L
E
N
-----
L
T
L
--------
E
G
G
V
T
I
H
A
T
K
D
L
K
T
A
Y
F
D
K
L
N
E
L
GKL
T
E
----------------------------------------------
A
----------------------------------------
I
Q
C
---
K
T
V
--------------------------------
S
--------------------------------------
L
D
L
A
A
K
F
V
T
S
T
E
S
A
I
Q
H
I
N
T
H
S
S
R
----
H
T
D
A
I
V
T
E
N
K
A
N
A
E
K
F
M
--
K
G
V
D
S
S
G
V
Y
W
N
A
S
T
R
F
-
A
---------
D
-----------------------
V
G
L
D
G
L
V
S
Y
Q
Y
Q
I
R
G
D
G
Q
V
A
S
------
4
PsiBlast_PDB
77.32
28%
-86
- C2 -
4JBE
14
?
A:
[41-440]
-----------------------------------------------------------
V
E
E
C
A
R
A
A
K
S
A
A
P
---
S
-
L
S
G
A
---
P
D
T
A
I
D
A
A
L
E
S
M
A
D
R
L
L
A
H
R
D
A
V
L
A
------
A
N
A
E
D
I
A
K
A
E
A
G
G
M
S
A
G
L
L
D
R
L
T
I
T
E
-
S
R
L
T
D
-
M
A
D
Q
L
R
L
L
A
G
A
P
H
-
P
-----
Q
R
T
V
E
L
S
---
T
L
D
G
G
L
R
L
V
E
R
R
R
P
V
G
V
I
G
A
N
--
Y
E
-
A
R
P
N
V
-
T
V
D
V
A
S
--
Q
L
V
K
S
R
N
A
G
V
L
R
T
G
S
A
A
L
--
K
S
A
Q
R
L
-
L
--
E
V
V
I
R
P
A
L
T
----
D
S
G
I
D
A
N
V
V
Q
L
V
P
R
P
E
--
R
E
A
A
G
A
-
L
V
R
L
P
D
L
V
P
L
V
I
---
L
R
G
S
G
E
S
T
R
A
L
A
L
E
A
A
Q
-----
H
---
G
V
R
T
L
A
H
A
D
G
G
G
V
L
Y
V
D
E
K
A
D
R
D
T
V
R
S
L
V
V
N
S
-
L
D
R
-
L
-
G
V
C
N
R
L
N
L
L
L
I
H
D
A
V
Y
E
E
F
W
P
V
V
S
E
-----
A
L
A
--------
E
R
G
V
S
P
S
L
P
P
Y
---------------
D
H
----------------------------------------------
P
----------------------------------------
I
G
-
Y
--
E
W
A
---------
L
D
---
S
E
R
---------------
E
--------------------------------------
A
T
V
T
V
A
R
V
D
G
V
A
E
A
V
R
I
A
N
E
E
T
S
G
----
L
A
A
G
I
A
T
E
D
A
R
A
A
E
E
F
F
--
D
G
Y
Q
G
T
G
V
F
W
N
A
P
T
R
L
-
L
---------
D
G
F
K
L
L
G
V
P
E
T
G
I
N
L
D
K
V
P
G
P
R
G
P
V
T
Y
P
D
L
Y
V
R
Q
Y
A
V
L
P
V
E
R
---------
30
HHSearch
76.95
36%
-95
- C2 -
1VLU
1
PROA_YEAST
A:
[13-444]
--------------------------------------------------------
M
S
S
S
Q
Q
I
A
K
N
A
R
K
A
G
N
---
I
-
L
K
T
I
---
S
N
E
G
R
S
D
I
L
Y
K
I
H
D
A
L
K
A
N
A
H
A
I
E
E
A
N
K
I
D
L
A
V
A
K
E
T
G
L
A
----
D
S
L
L
K
R
L
D
L
F
-
K
G
-
D
K
F
E
V
-
M
L
Q
G
I
K
D
V
A
E
L
E
D
-
P
-
V
--
G
K
V
K
M
A
R
E
---
L
D
D
G
-
L
T
L
Y
Q
V
T
A
P
V
G
V
L
L
V
I
--
F
E
-
S
R
P
E
V
-
I
A
N
I
T
A
--
L
S
I
K
S
G
N
A
A
I
L
K
G
G
K
E
S
V
--
N
T
F
R
E
M
-
A
--
K
-
I
V
N
D
T
I
A
Q
F
Q
S
E
T
G
V
P
V
G
S
V
Q
L
I
E
T
-
R
-----
V
S
D
-
L
L
D
Q
D
E
Y
I
D
L
V
V
---
P
R
G
S
N
A
L
V
R
K
I
---
K
D
T
-----
T
---
K
I
P
V
L
G
H
A
D
G
I
C
S
I
Y
L
D
E
D
A
D
L
I
K
A
K
-
R
I
S
L
D
A
K
T
N
-----
C
N
A
M
E
T
L
L
I
N
P
K
F
-
S
K
W
W
E
V
L
E
N
-----
L
T
L
--------
E
--
G
G
V
T
I
-
H
A
---------------
T
K
D
L
K
T
A
Y
F
D
K
L
N
E
L
GK-------------------------------
L
----------------------------------------
T
E
A
I
Q
C
K
T
----------
V
----------------------
S
--------------------------------------
L
D
L
A
A
K
F
V
T
S
T
E
S
A
I
Q
H
I
N
T
H
S
S
R
----
H
T
D
A
I
V
T
E
N
K
A
N
A
E
K
F
M
--
K
G
V
D
S
S
G
V
Y
W
N
A
S
T
R
F
-
A
---------
D
-----------------------
V
G
L
D
G
L
V
S
Y
Q
Y
Q
I
R
G
D
G
Q
V
A
S
------
35
HHSearch
70.26
19%
-76
- C2 -
3K2W
4
?
A:
[50-488]
---------------------------------------------------------
A
D
A
E
N
A
L
E
V
A
Q
A
A
Q
K
---
A
-
W
A
K
L
---
T
A
R
T
R
Q
N
M
L
R
T
F
A
N
K
I
R
E
N
K
H
I
L
A
P
------
M
L
V
A
E
Q
G
K
L
----
L
S
V
A
E
-
M
E
--------
V
D
V
-
T
A
T
F
I
D
Y
G
C
D
N
A
L
-
T
I
E
--
G
D
I
L
P
S
-----
D
N
Q
D
-
E
K
I
Y
I
H
K
V
P
R
G
V
V
V
G
I
--
T
A
W
N
F
P
L
A
L
A
G
R
K
I
G
--
P
A
L
I
T
G
N
T
M
V
L
K
P
T
Q
E
T
P
--
L
A
T
T
E
L
-
G
--
R
-
I
A
K
E
A
--------
G
L
P
D
G
V
L
N
V
I
N
G
T
G
---
S
V
V
G
Q
-
T
L
C
E
S
P
I
T
K
M
I
T
---
M
T
G
S
T
V
A
G
K
Q
I
---
Y
K
T
S
AE--
Y
---
M
T
P
V
M
L
E
L
G
G
K
A
P
M
V
V
M
D
D
A
D
L
D
K
A
A
E
D
A
L
W
G
R
F
A
N
C
G
-
Q
V
C
T
C
V
E
R
L
Y
V
H
A
S
V
Y
D
E
F
M
A
K
F
L
P
-----
L
V
K
--------
G
----
L
K
V
-
G
D
---------------
P
M
----------------------------------------------
D
ADSQ
M
G
P
K
CN
Q
R
E
I
D
N
I
D
H
I
V
H
E
A
I
K
Q
G
A
T
V
ATGGK-----
G
C
W
Y
E
P
T
V
---------
L
V
DVK
Q
D
N
-------
I
V
V
H
E
E
T
F
G
--------------------------------------
P
I
L
P
I
V
K
V
S
S
M
E
Q
A
I
E
F
C
N
D
S
I
Y
G
----
L
S
A
Y
V
H
T
Q
S
F
A
N
I
N
Q
A
I
--
S
D
L
E
V
G
E
V
Y
I
N
R
G
M
G
E
-
Q
---------
H
Q
G
F
H
N
G
W
K
Q
S
G
F
G
G
----
E
-
D
G
K
F
G
L
E
Q
Y
L
E
K
K
T
V
Y
I
N
E
A
E
---------
36
HHSearch
69.77
18%
-78
- C2 -
2J6L
4
AL7A1_HUMAN
A:
[58-499]
--------------------------------------------------------
V
A
D
Y
E
E
T
V
K
K
A
R
E
A
W
K
---
I
-
W
A
D
I
---
P
A
P
K
R
G
E
I
V
R
Q
I
G
D
A
L
R
E
K
I
Q
V
L
G
S
------
L
V
S
L
E
M
G
K
I
----
L
V
E
G
V
-
G
E
--------
V
Q
E
-
Y
V
D
I
C
D
Y
A
V
G
L
S
R
-
M
-
I
G
-
G
P
I
L
P
S
-----
E
R
S
G
-
H
A
L
I
E
Q
W
N
P
V
G
L
V
G
I
I
--
T
A
F
N
F
P
V
A
V
Y
G
W
N
N
A
--
I
A
M
I
C
G
N
V
C
L
W
K
G
A
P
T
T
S
--
L
I
S
V
A
V
-
T
--
K
-
I
I
A
K
V
L
E
----
D
N
K
L
P
G
A
I
C
S
L
T
C
G
-
G
---
A
D
I
G
T
-
A
M
A
K
D
E
R
V
N
L
L
S
---
F
T
G
S
T
Q
V
G
K
Q
V
---
G
L
M
V
Q
E
--
R
---
F
G
R
S
L
L
E
L
G
G
N
N
A
I
I
A
F
E
D
A
D
L
S
L
V
V
P
S
A
L
F
A
A
V
G
T
A
G
-
Q
R
C
T
T
A
R
R
L
F
I
H
E
S
I
H
D
E
V
V
N
R
L
K
K
-----
A
Y
A
--------
Q
----
I
R
V
-
G
N
---------------
P
W
----------------------------------------------
D
PNVL
Y
G
P
L
HT
K
Q
A
V
S
M
F
L
G
A
V
E
E
A
K
K
E
GGTVVYGGKVMDR
P
G
N
Y
V
E
P
T
I
---------
V
T
GLG
H
D
A
-------
S
I
A
H
T
E
T
F
A
--------------------------------------
P
I
L
Y
V
F
K
F
Q
N
E
E
E
V
F
A
W
N
N
E
V
K
Q
G
----
L
S
S
S
I
F
T
K
D
L
G
R
I
F
R
W
L
GP
K
G
S
D
C
G
I
V
N
V
N
I
P
T
S
G
A
E
---------
I
G
G
A
F
G
G
E
K
H
T
G
G
G
R
----
E
-
S
G
S
D
A
W
K
Q
Y
M
R
R
S
T
C
T
I
N
Y
S
----------
34
HHSearch
69.11
20%
-76
- C2 -
3PRL
1
?
A:
[49-483]
---------------------------------------------------------
E
E
V
N
D
A
I
Q
G
A
K
D
A
Q
K
---
I
-
W
K
I
R
---
P
I
H
E
R
V
D
L
L
Y
A
W
A
D
L
L
E
E
R
K
E
I
I
G
E
------
L
I
M
H
E
V
A
K
P
----
K
K
S
A
I
-
G
E
--------
V
S
R
-
T
A
D
I
I
R
H
T
A
D
E
A
L
-
R
-
L
N
-
G
E
T
L
K
G
D
Q
FKG
G
S
S
K
-
K
I
A
L
V
E
R
E
P
L
G
V
V
L
A
I
--
S
P
F
N
Y
P
V
N
L
A
A
A
K
I
A
--
P
A
L
V
T
G
N
T
V
V
F
K
P
A
T
Q
G
S
--
L
S
G
I
K
M
-
V
--
E
-
A
L
A
D
A
--------
G
A
P
E
G
I
I
Q
V
V
T
G
R
G
---
S
V
I
G
D
-
H
L
V
E
H
P
G
I
D
M
I
T
---
F
T
G
G
T
T
T
G
E
R
I
---
S
E
K
A----
K
---
M
I
P
V
V
L
E
L
G
G
K
D
P
A
I
V
L
D
D
A
D
L
K
L
T
A
S
Q
I
V
S
G
A
F
S
Y
S
G
-
Q
R
C
T
A
I
K
R
V
F
V
Q
D
S
V
A
D
Q
L
V
A
N
I
K
E
-----
L
V
E
--------
Q
----
L
T
V
-
G
S
---------------
P
E
DDADITPVID
E
K
S
A
A
F
I
Q
G
L
I
D
D
A
L
E
N
G
A
T
L
LSGNK----------
R
----------------------------------------
Q
G
N
L
LS
P
T
L
---------
L
D
DVT
P
A
M
-------
R
V
A
W
E
E
P
F
G
--------------------------------------
P
V
L
P
I
I
R
V
K
D
A
N
E
A
I
S
L
S
N
Q
S
D
Y
G
----
L
Q
A
S
I
F
T
K
D
T
D
R
A
I
N
I
G
--
K
H
L
E
V
G
T
V
H
I
N
A
K
T
E
R
G
P
---------
D
H
F
P
F
L
G
V
K
K
S
G
L
G
V
----
Q
-
G
I
K
P
S
L
L
S
M
T
R
E
R
V
T
V
L
N
L
-----------
28
HHSearch
68.37
19%
-77
- C2 -
3R64
-
?
A:
[50-487]
---------------------------------------------------------
A
D
V
D
A
A
Y
E
A
A
K
K
A
Q
A
---
E
-
W
A
A
T
---
P
A
A
E
R
S
A
I
I
Y
R
A
A
E
L
L
E
E
H
R
E
E
I
V
E
------
W
L
I
K
E
S
G
S
T
----
R
S
K
A
N
-
L
E
--------
I
T
L
-
A
G
N
I
T
K
E
S
A
S
F
P
G
-
R
-
V
H
-
G
R
I
S
P
S
-----
N
T
P
G
-
K
E
N
R
V
Y
R
V
A
K
G
V
V
G
V
I
--
S
P
W
N
F
P
L
N
L
S
I
R
S
V
A
--
P
A
L
A
V
G
N
A
V
V
I
K
P
A
S
D
T
P
--
V
T
G
G
V
I
P
A
--
R
-
I
F
E
E
A
--------
G
V
P
A
G
V
I
S
T
V
A
G
A
G
---
S
E
I
G
D
-
H
F
V
T
H
A
V
P
K
L
I
S
---
F
T
G
S
T
P
V
G
R
R
V
---
G
E
L
A
I
N
GG
P
---
M
K
T
V
A
L
E
L
G
G
N
A
P
F
V
V
L
A
D
A
D
I
D
A
A
A
Q
A
A
A
V
G
A
F
L
H
Q
G
-
Q
I
C
M
S
I
N
R
V
I
V
D
A
A
V
H
D
E
F
L
E
K
F
V
E
-----
A
V
K
--------
N
----
I
P
T
-
G
D
---------------
P
S
----------------------------------------------
A
EGTL
V
G
P
V
IN
D
S
Q
L
S
G
L
K
E
K
I
E
L
A
K
K
E
GATVQ
V
E
G
P
I---
E
G
R
L
V
H
P
H
V
---------
F
S
DVT
S
D
M
-------
E
I
A
R
E
E
I
F
G
--------------------------------------
P
L
I
S
V
L
K
A
D
D
E
A
H
A
A
E
L
A
N
A
S
D
F
G
----
L
S
A
A
V
W
S
K
D
I
D
R
A
A
Q
F
A
--
L
Q
I
D
S
G
M
V
H
I
N
D
-----------------------------
R
----
F
-
N
G
D
W
A
I
E
E
F
T
T
D
R
W
I
G
I
K
R
S
A
E
N
L
------
26
HHSearch
65.91
19%
-77
* C2 *
3U4J
-
?
A:
[61-501]
---------------------------------------------------------
D
D
V
R
K
A
V
A
A
A
R
K
A
F
D
AG-
P
-
W
P
R
M
---
S
G
A
E
R
S
R
L
M
F
K
V
A
D
L
I
L
A
R
Q
E
E
L
A
L
------
I
E
S
L
E
V
G
K
P
----
I
A
Q
A
R
-
G
E
--------
I
G
F
-
C
A
D
L
W
S
Y
A
A
G
Q
A
R
-
A
L
E
--
G
Q
T
H
N
N
-----
I
G
D
D
-
R
L
G
L
V
L
R
E
P
V
G
V
V
G
I
I
--
T
P
W
N
F
P
F
I
I
A
S
E
R
V
P
--
W
A
I
G
S
G
C
T
V
V
L
K
P
S
E
F
T
S
--
G
T
S
I
R
L
-
A
--
E
-
L
A
R
E
A
--------
G
I
P
D
G
V
F
N
V
V
T
G
Y
G
---
D
P
A
G
Q
-
V
L
A
E
D
P
N
V
D
M
V
A
---
F
T
G
S
V
R
V
G
T
K
L
---
G
E
I
A
A
R
--
T
---
V
K
R
V
G
L
E
L
G
G
K
G
P
Q
I
V
F
A
D
A
D
L
D
A
A
A
D
G
I
A
Y
G
V
Y
H
N
A
G
-
Q
C
C
I
S
G
S
R
L
L
V
Q
E
G
I
R
D
A
L
M
E
R
L
L
D
-----
I
S
R
--------
K
----
V
A
F
-
G
D
---------------
P
L
NERTK
I
G
A
M
IS
E
A
H
A
E
K
V
H
S
Y
V
T
A
G
I
T
S
GAELLLGGERIGR-----
E
----------------------------------------
A
G
L
Y
Y
A
P
T
V
---------
F
A
GVT
P
D
M
-------
S
I
A
R
E
E
I
F
G
--------------------------------------
P
V
L
S
T
L
T
F
K
T
A
D
E
A
V
A
L
A
N
A
T
E
F
G
----
L
S
A
S
V
W
S
T
N
L
E
T
A
L
Q
T
I
--
R
R
I
R
A
G
R
C
W
I
N
S
V
I
D
G
-
T
---------
P
E
L
P
I
G
G
Y
K
K
S
G
L
G
R
----
E
-
L
G
R
Y
G
F
D
E
Y
S
Q
F
K
G
V
H
V
T
L
G
R
P
A
P
------
44
HHSearch
65.54
18%
-78
- C2 -
1O04
2
ALDH2_HUMAN
A:
[57-498]
---------------------------------------------------------
E
D
V
D
K
A
V
K
A
A
R
A
A
F
Q
LGS
P
-
W
R
R
M
---
D
A
S
H
R
G
R
L
L
N
R
L
A
D
L
I
E
R
D
R
T
Y
L
A
A
------
L
E
T
L
D
N
G
K
P
----
Y
V
I
S
Y
L
V
D
--------
L
D
M
-
V
L
K
C
L
R
Y
Y
A
G
W
A
D
-
K
-
Y
H
-
G
K
T
I
P
------
I
D
G
D
-
F
F
S
Y
T
R
H
E
P
V
G
V
C
G
Q
I
--
I
P
W
N
F
P
L
L
M
Q
A
W
K
L
G
--
P
A
L
A
T
G
N
V
V
V
M
K
V
A
E
Q
T
P
--
L
T
A
L
Y
V
-
A
--
N
-
L
I
K
E
A
--------
G
F
P
P
G
V
V
N
I
V
P
G
F
G
---
P
T
A
G
A
-
A
I
A
S
H
E
D
V
D
K
V
A
---
F
T
G
S
T
E
I
G
R
V
I
---
Q
V
A
A
G
S
S
-
N
---
L
K
R
V
T
L
E
L
G
G
K
S
P
N
I
I
M
S
D
A
D
M
D
W
A
V
E
Q
A
H
F
A
L
F
F
N
Q
G
-
Q
C
S
C
A
G
S
R
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
V
A
-----
R
A
K
--------
S
----
R
V
V
-
G
N
---------------
P
F
DSKTEQGPQVD
E
T
Q
F
K
K
I
L
G
Y
I
N
T
G
K
Q
E
GAKLLCGGGIAA------
D
----------------------------------------
R
G
Y
F
IQ
P
T
V
---------
F
G
DVQ
D
G
M
-------
T
I
A
K
E
E
I
F
G
--------------------------------------
P
V
M
Q
I
L
K
F
K
T
I
E
E
V
V
G
R
A
N
N
S
T
Y
G
----
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Y
L
S
--
Q
A
L
Q
A
G
T
V
W
V
N
C
Y
D
V
F
-
G
---------
A
Q
S
P
F
G
G
Y
K
M
S
G
S
G
R
----
E
-
L
G
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
V
K
V
P
Q
K
N
S
------
25
HHSearch
65.07
19%
-70
- C2 -
3EK1
2
?
A:
[70-503]
---------------------------------------------------------
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
---
G
-
W
A
A
K
---
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
------
I
M
T
S
E
Q
G
K
P
----
L
A
E
A
R
-
G
E
--------
V
L
Y
-
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
-
Y
--
G
D
T
I
P
A
-----
P
Q
N
G
-
Q
R
L
T
V
I
R
Q
P
V
G
V
T
A
A
I
--
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
--
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
--
L
T
A
L
A
L
-
G
--
V
-
L
A
E
K
A
--------
G
I
P
A
G
V
L
Q
I
V
T
G
K
A
---
R
E
I
G
A
-
E
L
T
S
N
D
T
V
R
K
L
S
---
F
T
G
S
T
E
V
G
R
L
L
---
M
A
Q
-----
C
APT
I
K
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
-
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
-----
K
V
K
--------
E
----
L
K
V
-
G
N
---------------
G
T
----------------------------------------------
E
PGVVIGPMIE
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
GAKLITGGKEL--
G
G
L
F
F
E
P
G
I
---------
L
T
GVT
S
D
M
-------
L
V
A
K
E
E
T
F
G
--------------------------------------
P
L
A
P
L
F
A
F
D
T
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
----
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
--
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
-
N
---------
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
----
E
-
G
S
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
K
R
---------
37
HHSearch
64.66
19%
-78
- C2 -
3PQA
2
LADH_METJA
A:
[34-464]
---------------------------------------------------------
E
E
A
K
E
A
I
D
T
A
E
K
Y
K
E
---
V
-
M
K
N
L
---
P
I
T
K
R
Y
N
I
L
M
N
I
A
K
Q
I
K
E
K
K
E
E
L
A
K
------
I
L
A
I
D
A
G
K
P
----
I
K
Q
A
R
-
V
E
--------
V
E
R
-
S
I
G
T
F
K
L
A
A
F
Y
V
K
-
E
H
R
--
D
E
V
I
P
-------
S
D
D
-
R
L
I
F
T
R
R
E
P
V
G
I
V
G
A
I
--
T
P
F
N
F
P
L
N
L
S
A
H
K
I
A
--
P
A
I
A
T
G
N
V
I
V
H
H
P
S
S
K
A
P
--
L
V
C
I
E
L
-
A
--
K
-
I
I
E
N
A
L
K
----
K
Y
N
V
P
L
G
V
Y
N
L
L
T
G
A
G
---
E
V
V
G
D
-
E
I
V
V
N
E
K
V
N
M
I
S
---
F
T
G
S
S
K
V
G
E
L
I
---
T
K
K
A----
G
---
F
K
K
I
A
L
E
L
G
G
V
N
P
N
I
V
L
K
D
A
D
L
N
K
A
V
N
A
L
I
K
G
S
F
I
Y
A
G
-
Q
V
C
I
S
V
G
M
I
L
V
D
E
S
I
A
D
K
F
I
E
M
F
V
N
-----
K
A
K
--------
V
----
L
N
V
-
G
N
---------------
P
L
----------------------------------------------
D
EKTD
V
G
P
L
IS
V
E
H
A
E
W
V
E
K
V
V
E
K
A
I
D
E
GGKLLLGGKRD--
K
A
L
F
Y-
P
T
I
---------
L
E
V
D
-
R
D
N
-------
I
L
C
K
T
E
T
F
A
--------------------------------------
P
V
I
P
I
I
R
T
-
N
E
E
E
M
I
D
I
A
N
S
T
E
Y
G
----
L
H
S
A
I
F
T
N
D
I
N
K
S
L
K
F
A
--
E
N
L
E
F
G
G
V
V
I
N
D
S
S
L
F
R
Q
---------
D
N
M
P
F
G
G
V
K
K
S
G
L
G
R
----
E
-
G
V
K
Y
A
M
E
E
M
S
N
I
K
T
I
I
I
S
K
-----------
46
HHSearch
64.39
20%
-77
- C2 -
1A4S
-
BADH_GADMC
A:
[58-498]
---------------------------------------------------------
E
E
V
D
Q
A
V
Q
S
A
Q
A
A
Y
L
---
K
-
W
S
K
M
---
A
G
I
E
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
------
L
E
V
I
N
N
G
K
T
----
I
T
E
A
E
-
Y
--------
D
I
D
A
-
A
W
Q
C
I
E
Y
Y
A
G
L
A
P
T
L
-
S
--
G
Q
H
I
Q
------
L
P
G
G
-
A
F
A
Y
T
R
R
E
P
L
G
V
C
A
G
I
--
L
A
W
N
Y
P
F
M
I
A
A
W
K
C
A
--
P
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
--
V
T
G
V
I
L
-
A
--
E
-
I
F
H
E
A
--------
G
V
P
V
G
L
V
N
V
V
Q
G
G
----
A
E
T
G
S
-
L
L
C
H
H
P
N
V
A
K
V
S
---
F
T
G
S
V
P
T
G
K
K
V
---
M
E
M
S
A
K
--
T
---
V
K
H
V
T
L
E
L
G
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
L
T
Q
G
-
Q
V
C
T
N
G
T
R
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
-----
R
T
K
--------
A
----
I
V
V
-
G
D
---------------
P
L
LTETRMGGLIS
K
P
Q
L
D
K
V
L
G
F
V
A
Q
A
K
K
E
G
A
R
V
LCGG
E
P
L
T
P
SDPKL
K
----------------------------------------
N
G
Y
F
M
S
P
C
V
---------
L
D
NCR
D
D
M
-------
T
C
V
K
E
E
I
F
G
--------------------------------------
P
V
M
S
V
L
P
F
D
T
E
E
E
V
L
Q
R
A
N
N
T
T
F
G
----
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
--
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
S
-
P
---------
V
E
V
P
F
G
G
Y
K
M
S
G
F
G
R
----
E
-
N
G
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
I
V
E
M
G
D
V
D
S
------
49
Fugue
63.47
17%
-76
- C2 -
3K9D
1
?
A:
[3-456]
---------------------------------------------------LED
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
---
A
-
Q
K
E
L
---
A
A
M
S
-
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
------
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
-
K
H
V
Y
N
-
Y
I
K
D
M
---------------
K
T
I
G
M
L
K
---
E
D
N
E
-
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
--
I
P
-
S
T
N
P
T
-
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
--
K
A
I
L
E
T
-
V
--
R
-
I
I
S
E
A
A
E
----
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
--
I
Q
G
T
D
Q
-
L
M
K
H
K
D
-
T
A
V
I
L
---
A
T
G
G
S
A
M
V
K
A
A
---
Y
S
------
S
---
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
-
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
L
S
D
--------
A
E
A
V
Q
L
G
K
F
I
L
---------------
R
P
NGSMNPAIVGKS----------------------------------
V
----------------------------------------
Q
H
I
A
--
N
L
A
G
L
T
V
P
ADAR
V
L
---
I
A
E
E
TKVGAK
I
P
Y
S
R
E
K
L
A
--------------------------------------
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
EGAG
H
T
L
I
I
H
S
E
D
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
-
G
G
I
GATTNLV
P
A
L
T
L
G
C
G
A
V
G
G
S
S
S
S
D
N
------
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
IR----
33
HHSearch
62.66
14%
-78
- C2 -
3I44
1
?
A:
[63-496]
---------------------------------------------------------
R
D
A
D
K
A
I
N
A
A
K
K
A
F
Q
---
T
-
W
K
T
T
---
S
P
H
E
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
------
T
I
S
M
E
M
G
A
P
----
I
D
M
A
L
N
A
Q
--------
T
A
T
-
G
S
S
H
I
R
N
F
I
K
A
Y
K
-
E
-
F
SF
Q
E
A
L
-------
I
E
G
N
-
E
Q
A
I
L
H
Y
D
A
I
G
V
V
G
L
I
--
T
P
W
N
W
P
M
N
Q
V
T
L
K
V
I
--
P
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
--
L
S
A
M
L
F
-
A
--
E
-
I
L
D
E
A
--------
A
L
P
S
G
V
F
N
L
I
N
G
D
G
---
A
N
V
G
S
-
Y
L
S
A
H
P
D
L
E
M
I
S
---
F
T
G
S
T
R
A
G
K
D
I
---
S
K
N
A
SN--
T
---
L
K
R
V
C
L
E
L
G
G
K
G
A
N
I
I
F
A
D
A
D
I
D
A
L
Q
-
R
G
V
R
H
C
F
Y
N
S
G
-
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
I
Y
D
K
A
I
K
T
A
K
D
-----
I
A
E
--------
K
----
T
Q
V
-
G
P
---------------
G
H
QTGN
H
I
G
P
VVS
K
E
Q
Y
D
K
I
Q
D
L
I
Q
S
G
I
D
E
GATLVTGGTGLPMGM---
E
----------------------------------------
R
G
Y
Y
VR
P
T
V
---------
F
A
DVK
P
H
M
-------
R
I
F
R
E
E
I
F
G
--------------------------------------
P
V
L
S
L
L
P
F
N
T
E
D
E
A
V
T
L
A
N
D
T
E
Y
G
----
L
T
N
Y
I
Q
S
Q
D
R
S
K
C
R
R
I
A
--
A
Q
V
R
S
G
M
V
E
V
N
G
H
E
L
--
P
---------
G
G
S
Y
F
G
G
V
K
F
S
G
R
A
R
----
E
-
G
G
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
W
------------
38
HHSearch
62.05
15%
-72
- C2 -
2W8N
6
SSDH_HUMAN
A:
[48-485]
---------------------------------------------------------
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
---
R
-
W
R
E
V
---
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
------
I
I
T
A
E
S
G
K
P
----
L
K
E
A
H
-
G
E
--------
I
L
Y
-
S
A
F
F
L
E
W
F
S
E
E
A
R
R
V
-
Y
--
G
D
I
I
H
T
-----
P
A
K
D
-
R
R
A
L
V
L
K
Q
P
I
G
V
A
A
V
I
--
T
P
W
N
F
P
S
A
M
I
T
R
K
V
G
--
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
--
F
S
A
L
A
L
-
A
--
E
-
L
A
S
Q
A
--------
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
KN
A
K
E
V
G
E
-
A
I
C
T
D
P
L
V
S
K
I
S
---
F
T
G
S
T
T
T
G
K
I
L
---
L
H
H
A
A
N
--
S
---
V
K
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
V
A
G
A
M
A
S
K
F
R
N
T
G
-
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
I
H
D
A
F
V
K
A
F
A
E
-----
A
M
K
--------
K
N
---
L
R
V
-
G
N
---------------
G
F
----------------------------------------------
E
EGTT
Q
G
P
L
IN
E
K
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
GATVVTGGKRHQL
G
K
N
F
FE
P
T
L
---------
L
C
NVT
Q
D
M
-------
L
C
T
H
E
E
T
F
G
--------------------------------------
P
L
A
P
V
I
K
F
D
T
E
E
E
A
I
A
I
A
N
A
A
D
V
G
----
L
A
G
Y
F
Y
S
Q
D
P
A
Q
I
W
R
V
A
--
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
-
S
---------
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
----
E
-
G
S
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
G
L
----------
1
PsiBlast_PDB
61.86
46%
-6
- C2 -
1O20
-
PROA_THEMA
A:
[4-415]
--------------------------------------------------------------
L
L
E
K
A
K
K
V
R
E
---
A
-
W
D
V
L
R
N
A
T
T
R
E
K
N
K
A
I
K
K
I
A
E
K
L
D
E
R
R
K
E
I
L
E
------
A
N
R
I
D
V
E
K
A
R
E
R
G
V
K
E
S
L
V
D
R
L
A
L
N
D
-
K
R
I
D
E
-
M
I
K
A
C
E
T
V
I
G
L
K
D
-
P
-
V
--
G
E
V
I
D
S
W
V
---
R
E
D
G
-
L
R
I
A
R
V
R
V
P
I
G
P
I
G
I
I
--
Y
E
-
S
R
P
N
V
-
T
V
E
T
T
I
--
L
A
L
K
S
G
N
T
I
L
L
R
G
G
S
D
A
L
--
N
S
N
K
A
I
-
V
--
S
-
A
I
R
E
A
L
K
----
E
T
E
I
P
E
S
S
V
E
F
I
E
N
T
D
--
R
S
L
V
L
E
-
M
I
R
L
R
E
Y
L
S
L
V
I
---
P
R
G
G
Y
G
L
I
S
F
V
---
R
D
N
-----
A
---
T
V
P
V
L
E
T
G
V
G
N
C
H
I
F
V
D
E
S
A
D
L
K
K
A
V
P
V
I
I
N
A
K
T
Q
R
-
P
-
G
T
C
N
A
A
E
K
L
L
V
H
E
K
I
A
K
E
F
L
P
V
I
V
E
-----
E
L
R
--------
K
--
H
G
V
E
V
R
G
C
---------------
E
K
----------------------------------------------
T
----------------------------------------
R
E
I
V
--
P
D
V
---------
V
P
---
A
T
E
-------
D
D
W
P
T
E
Y
L
D
--------------------------------------
L
I
I
A
I
K
V
V
K
N
V
D
E
A
I
E
H
I
K
K
Y
S
T
G
----
H
S
E
S
I
L
T
E
N
Y
S
N
A
K
K
F
V
--
S
E
I
D
A
A
A
V
Y
V
N
A
S
T
R
F
-
T
---------
D
G
G
Q
F
G
F
G
A
E
I
G
I
S
T
Q
R
F
H
A
-
R
G
P
V
G
L
R
E
L
T
T
Y
K
F
V
V
L
G
E
Y
H
V
R
E
------
42
HHSearch
61.32
17%
-70
- C2 -
3ROS
1
?
A:
[25-459]
--------------------------------------------------------
S
K
Q
I
D
E
A
I
N
L
A
H
A
L
Y
K
---
K
-
W
R
H
E
---
E
P
A
S
R
A
E
I
L
H
D
I
A
N
A
L
K
E
H
E
D
E
L
A
K
------
M
M
T
L
E
M
G
K
L
----
L
S
E
S
K
-
E
E
--------
V
E
L
-
C
V
S
I
C
N
Y
Y
A
D
H
G
P
-
E
M
L
--
K
P
T
K
L
------
N
S
D
L
-
G
N
A
Y
Y
L
K
Q
S
T
G
V
I
M
A
C
--
E
P
W
N
F
P
L
Y
Q
V
I
R
V
F
A
--
P
N
F
I
V
G
N
P
I
L
L
K
H
A
H
N
V
P
--
G
S
A
A
L
T
-
A
--
K
-
I
I
K
R
A
--------
G
A
P
E
G
S
L
I
N
L
Y
P
S
Y
---
D
Q
L
A
D
-
I
I
-
A
D
P
R
I
Q
G
V
A
---
L
T
G
S
E
R
G
G
S
A
V
---
A
E
A
A
G
K
--
N
---
L
K
K
S
T
M
E
L
G
G
N
D
A
F
I
V
L
D
D
A
D
P
Q
V
L
R
N
V
L
N
D
A
R
T
Y
N
D
G
-
Q
V
C
T
S
S
K
R
I
I
V
E
K
S
R
Y
D
E
V
L
H
E
L
K
N
-----
V
F
S
--------
N
----
L
K
A
-
G
D
---------------
P
L
----------------------------------------------
E
ADTTLPPMNS
E
K
A
K
E
K
L
E
A
Q
V
K
E
A
I
D
A
G
A
K
V
FYQY
P
E
I
D
S
K
G
A
F
F
R
P
T
I
---------
L
T
DIA
K
D
N
-------
P
V
F
D
K
E
V
F
G
--------------------------------------
P
I
A
E
V
F
V
V
E
D
D
N
A
A
I
Q
L
A
N
D
S
S
Y
G
----
L
G
S
S
V
I
G
S
D
I
D
R
A
K
K
V
S
--
A
Q
I
E
T
G
M
T
V
I
N
G
R
W
I
T
-
S
---------
G
E
L
P
F
G
G
I
K
K
S
G
Y
G
R
----
E
-
L
S
G
L
G
L
M
A
F
V
N
E
H
L
V
I
D
V
T
K
N
N
--------
47
Fugue
61.16
45%
-5
- C2 -
1O20
-
PROA_THEMA
A:
[2-415]
---------------------------------------------------------
D
E
L
L
E
K
A
K
K
V
R
E
A
W
D
---
V
-
L
R
N
A
---
T
T
R
E
K
N
K
A
I
K
K
I
A
E
K
L
D
E
R
R
K
E
I
L
E
------
A
N
R
I
D
V
E
K
A
R
E
R
G
V
K
E
S
L
V
D
R
L
A
L
N
D
-
K
R
I
D
E
M
I
-
K
A
C
E
T
V
I
G
L
K
D
-
P
-
V
--
G
E
V
I
D
S
W
V
---
R
E
D
G
-
L
R
I
A
R
V
R
V
P
I
G
P
I
G
I
I
--
Y
E
-
S
R
P
N
V
-
T
V
E
T
T
I
--
L
A
L
K
S
G
N
T
I
L
L
R
G
G
S
D
A
L
--
N
S
N
K
A
I
-
V
--
S
-
A
I
R
E
A
L
K
----
E
T
E
I
P
E
S
S
V
E
F
I
E
N
T
D
--
R
S
L
V
L
E
M
I
R
L
-
R
E
Y
L
S
L
V
I
---
P
R
G
G
Y
G
L
I
S
F
V
---
R
D
N
-----
A
---
T
V
P
V
L
E
T
G
V
G
N
C
H
I
F
V
D
E
S
A
D
L
K
K
A
V
P
V
I
I
N
A
K
T
Q
R
-
P
-
G
T
C
N
A
A
E
K
L
L
V
H
E
K
I
A
K
E
F
L
P
V
I
V
E
-----
E
L
R
--------
K
H
G
--
V
E
V
R
G
C
---------------
E
K
----------------------------------------------
T
----------------------------------------
R
E
I
V
--
P
D
V
---------
V
P
---
A
T
E
-------
D
D
W
P
T
E
Y
L
D
--------------------------------------
L
I
I
A
I
K
V
V
K
N
V
D
E
A
I
E
H
I
K
K
Y
S
T
G
----
H
S
E
S
I
L
T
E
N
Y
S
N
A
K
K
F
V
--
S
E
I
D
A
A
A
V
Y
V
N
A
S
T
R
F
-
T
---------
D
G
G
Q
F
G
F
G
A
E
I
G
I
S
T
Q
R
F
H
A
-
R
G
P
V
G
L
R
E
L
T
T
Y
K
F
V
V
L
G
E
Y
H
V
R
E
------
48
Fugue
60.47
18%
-76
- C2 -
1A4S
-
BADH_GADMC
A:
[1-503]
A
Q
L
V
D
S
MPSASTGSVVVTDDLNYWGG
R
R
I
K
S
K
DGAT
T
E
P
V
F
EPATGRVL
C
Q
M
V
P
C
G
A
E
E
V
D
Q
A
V
Q
S
A
Q
A
A
Y
L
----
K
W
S
K
M
---
A
G
I
E
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
------
L
E
V
I
N
N
G
K
T
----
I
T
E
A
E
-
Y
D
I
D
A
A
W
-
Q
C
I
E
Y
-
Y
A
G
L
A
P
T
L
-
S
---------
G
Q
H
I
Q
L
P
------
G
G
-
A
F
A
Y
T
R
R
E
P
L
G
V
C
A
G
I
L
A
W
N
-
Y
P
F
M
I
-
A
A
W
K
C
A
--
P
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
--
V
T
G
V
I
L
-
A
--
E
-
I
F
H
E
A
--------
G
V
P
V
G
L
V
N
V
V
Q
G
G
---
A
E
T
G
S
L
-
L
C
H
H
P
N
V
A
K
V
S
F
T
G
S
V
P
T
G
K
K
V
M
E
M
S
---
A
K
------
T
---
V
K
H
V
T
L
E
L
G
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
L
T
-
Q
G
Q
V
C
T
N
G
T
R
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
-----
R
T
K
A
I
V
V
G
DPL
L
T
E
T
R
M
G
G
L
I
S
---------------
K
P
----------------------------------------------
Q
----------------------------------------
L
D
K
V
--
L
G
F
---------
V
A
---
Q
A
K
-------
K
E
G
A
R
V
L
C
G
G
E
P
L
T
P
SDPKLKNGYFM
S
P
C
V
L
D
NCRDDMTCVKEEIFG
P
V
M
S
V
L
P
F
D
T
E
E
E
V
L
Q
R
A
N
N
T
T
F
G
----
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
--
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
------------
S
P
V
E
V
P
F
G
G
Y
K
M
S
G
F
G
R
E
N
---
G
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
I
V
E
-
M
G
---DVDSLF