@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0315: (2015-11-30 )
MKLERQKLLAKVAYLYYMEGKSQSEIANELGIYRTTISRMLAKAREEGLVRIEISDFNPEIFQLESYFKSKYHLKDIEIVSSRKDSDTSEIEKDLAHVAAAMIRKKIKENDKVGIAWGRTLSKVVEAMRPHPVSQVSFVPLAGGPSHINARYHVNTLVYEMSRRFQGSCTFINATLVQENANLAKGILTSKYFEGLMDNWEKLDVAIVGVGGKPKSNEQQWLDLLNQDDFQCLDEEAAVGEITCRFFNHSGDPVNQHLAKRTIGITLEQLQKVPNRIAVAHGNYKAAALLAVLKKGYINHLVTDFSTALNILRLDKDTFVDTIYQKS
Atome Classification :
(20 SA)
.........10........20........30........40........50....-....60-........70........80........90........100.......110........120.......130.-..-.-....140..-..-.-.-.150.......160........170-.......180.......190.......200.......210.......220--..-.....230.......240.......250..-.....260.......270.......280.......290.......300.......310.......320.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
L
E
R
Q
K
L
L
A
K
V
A
Y
L
Y
Y
MEGK
S
Q
S
E
I
A
N
E
L
G
I
Y
R
T
T
I
S
R
M
L
A
K
A
R
EE
G
L
V
R
I
E
IS-DFNP
E
I
-
F
Q
L
E
S
Y
F
KSKYH
L
K
D
I
E
I
VSSRKDS
D
T
S
E
I
E
K
D
L
A
H
V
A
A
A
M
I
R
K
K
IKEND-
K
V
G
I
A
W
G
R
T
L
S
K
V
V
E
A
MRP-HP-VS-
Q
-
V
S
F
V
PLAGG-PS-H-
I
-
N
A
R
Y
H
V
N
T
L
V
Y
E
M
-
S
R
RFQG
S
C
T
F
I
-
N
A
T
L
VQENA
N
L
A
K
G
I
L
T
S
K
Y
F
E
G
L
MD
N
W
E
K
L
D
V
A
I
V
GVGGKPKS
N
E
Q
Q
W
L
--
D
L
-LNQD
D
F
Q
C
LDEEAAV
G
E
I
T
C
R
F
FNHSGD
P
V
-
N
Q
H
L
A
K
R
TIG
I
T
L
E
Q
L
Q
KVPN
R
I
A
V
AHGN
Y
K
A
A
A
L
L
A
V
L
K
K
G
Y
I
N
H
L
V
T
D
F
S
T
A
L
N
I
L
RLDK
D
T
F
V
D
T
I
YQKS
23
HHSearch
96.09
48%
-115
- C4 -
2GNP
1
?
A:
[8-265]
------------------------------------------------------------
N
M
-
F
K
L
E
N
Y
V
K
E
K
Y
S
L
E
S
L
E
I
I
P
N
E
F
D
D
T
P
T
I
L
S
E
R
I
S
Q
V
A
A
G
V
L
R
N
L
I
D
D
N
M
-
K
I
G
F
S
W
G
K
S
L
S
N
L
V
D
L
I
H
S
-
K
S
-
V
R
-
N
-
V
H
F
Y
P
L
A
G
G
-
P
S
-
H
-
I
-
H
A
K
Y
H
V
N
T
L
I
Y
E
M
-
S
R
K
F
H
G
E
C
T
F
M
-
N
A
T
I
V
Q
E
N
K
L
L
A
D
G
I
L
Q
S
R
Y
F
E
N
L
K
N
S
W
K
D
L
D
I
A
V
V
G
I
G
D
F
S
N
K
G
K
H
Q
W
L
--
D
M
-
L
T
E
D
D
F
K
E
L
T
K
V
K
T
V
G
E
I
C
C
R
F
F
D
S
K
G
K
E
V
-
Y
E
N
L
Q
E
R
T
I
A
I
S
L
E
D
L
K
N
I
P
Q
S
L
A
V
A
Y
G
D
T
K
V
S
S
I
L
S
V
L
R
A
N
L
V
N
H
L
I
T
D
K
N
T
I
L
K
V
L
E
E
D
G
D
----------
1
PsiBlast_PDB
95.93
46%
-114
- C4 -
2GNP
1
?
A:
[4-265]
--------------------------------------------------------
N
F
D
T
N
M
-
F
K
L
E
N
Y
V
K
E
K
Y
S
L
E
S
L
E
I
I
P
N
E
F
D
D
T
P
T
I
L
S
E
R
I
S
Q
V
A
A
G
V
L
R
N
L
I
D
D
N
M
-
K
I
G
F
S
W
G
K
S
L
S
N
L
V
D
L
I
H
S
-
K
S
-
V
R
-
N
-
V
H
F
Y
P
L
A
G
G
-
P
S
-
H
-
I
-
H
A
K
Y
H
V
N
T
L
I
Y
E
M
-
S
R
K
F
H
G
E
C
T
F
M
-
N
A
T
I
V
Q
E
N
K
L
L
A
D
G
I
L
Q
S
R
Y
F
E
N
L
K
N
S
W
K
D
L
D
I
A
V
V
G
I
G
D
F
S
N
K
G
K
H
Q
W
L
--
D
M
-
L
T
E
D
D
F
K
E
L
T
K
V
K
T
V
G
E
I
C
C
R
F
F
D
S
K
G
K
E
V
-
Y
E
N
L
Q
E
R
T
I
A
I
S
L
E
D
L
K
N
I
P
Q
S
L
A
V
A
Y
G
D
T
K
V
S
S
I
L
S
V
L
R
A
N
L
V
N
H
L
I
T
D
K
N
T
I
L
K
V
L
E
E
D
G
D
----------
43
Fugue
92.94
33%
-111
- C4 -
2W48
3
SORC_KLEPN
A:
[4-315]
--
S
D
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
-
Y
D
Y
N
E
N
-
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
E
E
-----
E
Q
L
S
A
M
G
Q
H
G
A
L
L
V
D
R
L
L
E
P
G
D
-
I
I
G
F
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
R
S
Q
-
S
R
-
Q
-
V
I
C
V
P
I
I
G
G
-
P
S
-
G
K
L
-
E
S
R
Y
H
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
P
A
I
R
D
G
A
N
W
H
--
A
F
-
Y
G
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
-
D
T
N
M
S
E
K
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
R
Y
I
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
--------------
22
HHSearch
92.42
33%
-112
- C4 -
2W48
3
SORC_KLEPN
A:
[6-315]
----
D
I
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
-
Y
D
Y
N
E
N
-
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
-----
E
E
E
Q
L
S
A
M
G
Q
H
G
A
L
L
V
D
R
L
L
E
P
G
D
-
I
I
G
F
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
-
R
S
Q
S
R
-
Q
-
V
I
C
V
P
I
I
G
G
-
P
S
-
G
-
K
L
E
S
R
Y
H
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
P
A
I
R
D
G
A
N
W
H
--
A
F
-
Y
G
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
-
D
T
N
M
S
E
K
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
R
Y
I
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
--------------
2
PsiBlast_PDB
91.70
33%
-110
- C4 -
2W48
3
SORC_KLEPN
A:
[8-315]
------
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
Y
D
Y
N
E
N
L
-
W
-
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
----
E
E
E
Q
L
S
A
M
G
Q
H
-
G
A
L
L
V
D
R
L
L
E
P
G
D
-
I
I
G
F
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
-
R
S
-
Q
S
R
Q
-
V
I
C
V
P
I
I
G
G
-
P
S
G
K
-
L
-
E
S
R
Y
H
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
P
A
I
R
D
G
A
N
W
H
--
A
F
-
Y
G
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
-
D
T
N
M
S
E
K
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
R
Y
I
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
--------------
21
PsiBlast_CBE
90.59
33%
-100
- C4 -
2W48
1
SORC_KLEPN
B:
[8-315]
------
R
L
I
V
K
I
A
Q
L
Y
Y
E
Q
D
M
T
Q
A
Q
I
A
R
E
L
G
I
Y
R
T
T
I
S
R
L
L
K
R
G
R
E
Q
G
I
V
T
I
A
I
N
Y
D
Y
N
E
N
L
-
W
-
L
E
Q
Q
L
K
Q
K
F
G
L
K
E
A
V
V
A
S
S
D
G
L
L
E
E
E
Q
L
S
A
M
G
Q
H
-
G
A
L
L
V
D
R
L
L
E
P
G
D
-
I
I
G
F
S
W
G
R
A
V
R
S
L
V
E
N
L
P
Q
-
R
S
-
Q
S
R
Q
-
V
I
C
V
P
I
I
G
G
-
P
S
G
K
-
L
-
E
S
R
Y
H
V
N
T
L
T
Y
G
A
-
A
A
R
L
K
A
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
S
Y
W
D
S
L
D
V
A
L
V
G
I
G
S
P
A
I
R
D
G
A
N
W
H
--
A
F
-
Y
G
S
E
E
S
D
D
L
N
A
R
H
V
A
G
D
I
C
S
R
F
Y
D
I
N
G
G
L
V
-
D
T
N
M
S
E
K
T
L
S
I
E
M
A
K
L
R
Q
A
R
Y
S
I
G
I
A
M
G
E
E
K
Y
S
G
I
L
G
A
L
H
G
R
Y
I
N
C
L
V
T
N
R
E
T
A
E
L
L
L
K
--------------
6
PsiBlast_PDB
88.29
28%
-110
- C4 -
4L5J
1
LSRR_ECOLI
A:
[20-317]
--------
V
A
R
I
A
W
F
Y
Y
H
D
G
L
T
Q
S
E
I
S
D
R
L
G
L
T
R
L
K
V
S
R
L
L
E
K
G
H
Q
S
G
I
I
R
V
Q
I
N
-
S
R
F
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
A
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
Q
Q
-
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
Q
D
D
A
T
I
I
R
S
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
45
Fugue
87.79
42%
-105
- C4 -
2GNP
1
?
A:
[4-265]
---------------------------------------------------------
N
F
D
T
N
M
F
K
L
E
N
Y
V
K
E
K
Y
S
L
E
S
L
E
I
I
P
N
E
F
D
D
T
P
T
I
L
S
E
R
I
S
Q
V
A
A
G
V
L
R
N
L
I
-
D
D
N
M
K
I
G
F
S
W
G
K
S
L
S
N
L
V
D
L
I
H
S
-
K
S
-
V
R
-
N
-
V
H
F
Y
P
L
A
G
G
-
P
S
-
H
-
I
-
H
A
K
Y
H
-
V
N
T
L
I
Y
E
M
S
R
K
F
H
G
E
C
T
-
F
M
N
A
T
I
V
Q
E
N
K
L
L
A
D
G
I
L
Q
S
R
Y
F
E
N
L
K
N
S
W
K
D
L
D
I
A
V
V
G
I
-
G
D
F
S
N
K
G
K
H
Q
W
--
L
D
M
L
T
E
D
D
F
K
E
L
T
K
V
K
T
V
G
E
I
C
C
R
F
F
D
S
K
G
K
E
V
-
Y
E
N
L
Q
E
R
T
I
A
I
S
L
E
D
L
K
N
I
P
Q
S
L
A
V
A
Y
G
D
T
K
V
S
S
I
L
S
V
L
R
A
N
L
V
N
H
L
I
T
D
K
N
T
I
L
K
V
L
E
E
D
G
D
----------
5
PsiBlast_PDB
86.25
28%
-107
- C4 -
4L5I
-
LSRR_ECOLI
A:
[20-317]
--------
V
A
R
I
A
W
F
Y
Y
H
D
G
L
T
Q
S
E
I
S
D
R
L
G
L
T
R
L
K
V
S
R
L
L
E
K
G
H
Q
S
G
I
I
R
V
Q
I
N
-
S
R
F
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
A
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
Q
Q
-
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
Q
D
D
A
T
I
I
R
S
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
13
PsiBlast_PDB
84.46
26%
-112
- C4 -
4L51
1
LSRR_ECOLI
A:
[18-265]
-----------------------------------------------------------
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
---
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
-
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
Q
D
D
A
T
I
I
R
S
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
4
PsiBlast_PDB
83.72
28%
-105
- C4 -
4GO1
1
LSRR_ECOLI
A:
[19-316]
--------
V
A
R
I
A
W
F
Y
Y
H
D
G
L
T
Q
S
E
I
S
D
R
L
G
L
T
R
L
K
V
S
R
L
L
E
K
G
H
Q
S
G
I
I
R
V
Q
I
N
-
S
R
F
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
A
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
Q
Q
-
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
---------------
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
L
E
H
----------
10
PsiBlast_PDB
82.47
26%
-117
- C4 -
4L4Y
-
LSRR_ECOLI
A:
[18-265]
-----------------------------------------------------------
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
--
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
-
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
----------
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
12
PsiBlast_PDB
81.32
26%
-108
- C4 -
4L50
1
LSRR_ECOLI
A:
[17-265]
----------------------------------------------------------
F
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
--
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
-
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
Q
D
D
A
T
I
I
R
S
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
26
HHSearch
81.27
29%
-113
- C4 -
3EFB
-
?
A:
[12-266]
------------------------------------------------------------
E
N
-
L
W
L
E
Q
Q
L
K
Q
K
F
G
L
K
D
V
V
V
V
S
G
N
D
E
D
-
E
E
T
Q
L
A
M
M
G
L
H
G
A
Q
L
L
D
R
L
L
E
P
G
D
-
I
V
G
F
S
W
G
R
A
V
S
A
L
V
E
N
L
P
Q
-
A
G
Q
S
R
-
Q
-
L
I
C
V
P
I
I
G
G
-
P
S
-
G
-
K
L
E
S
R
Y
H
V
N
T
L
T
Y
S
A
-
A
A
K
L
K
G
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
A
Y
W
D
N
L
D
I
A
L
V
G
I
G
S
P
-----------
A
F
-
Y
G
G
E
E
S
D
D
L
N
A
R
Q
V
A
G
D
I
C
S
R
F
F
D
I
H
G
A
M
V
-
E
T
N
M
S
E
K
T
L
S
I
E
M
N
K
L
K
Q
A
R
Y
S
I
G
I
A
M
S
E
E
K
Y
S
G
I
I
G
A
L
R
G
K
Y
I
N
C
L
V
T
N
S
S
T
A
E
L
L
L
K
--------------
11
PsiBlast_PDB
78.21
26%
-108
- C4 -
4L4Z
1
LSRR_ECOLI
A:
[18-265]
-----------------------------------------------------------
E
G
C
-
L
E
Y
E
T
Q
L
R
R
Q
F
S
L
Q
H
V
R
V
I
P
G
L
A
D
A
D
---
V
G
G
R
L
G
I
G
A
A
H
M
L
M
S
L
L
Q
P
Q
Q
-
M
L
A
I
G
F
G
E
A
T
M
N
T
L
Q
R
L
S
G
-
F
I
-
S
S
-
Q
Q
I
R
L
V
T
L
S
G
G
V
G
S
-
Y
-
M
-
T
G
I
G
Q
L
N
A
A
C
----------
S
V
N
I
I
-
P
A
P
L
R
A
S
S
A
D
I
A
R
T
L
K
N
E
N
C
V
K
D
V
L
L
A
A
Q
A
A
D
V
A
I
V
G
I
G
A
V
S
Q
Q
D
D
A
T
I
I
R
S
G
Y
-
I
S
Q
G
E
Q
L
M
I
G
R
K
G
A
V
G
D
I
L
G
Y
F
F
D
A
K
G
D
V
V
T
N
I
K
I
H
N
E
L
I
G
L
P
L
S
A
L
K
T
I
P
V
R
V
G
V
A
G
G
E
N
K
A
E
A
I
A
A
A
M
K
G
G
Y
I
N
A
L
V
T
D
Q
D
T
A
A
A
I
L
R
S
-------------
7
PsiBlast_PDB
77.29
27%
-108
- C4 -
4R9N
-
?
A:
[7-244]
-----------------------------------------------------------------
L
E
Q
K
L
E
E
K
F
G
L
E
E
-
A
I
V
V
A
T
H
D
M
S
E
E
E
A
L
N
F
L
A
K
E
A
A
Y
T
L
S
K
R
I
A
K
V
K
-
T
L
G
I
S
W
G
K
T
I
R
K
F
A
N
E
F
P
F
-
I
P
-
H
K
-
D
-
L
T
I
I
P
L
I
G
G
----------
D
L
H
S
N
Q
I
C
Y
D
L
-
K
K
K
M
K
C
H
S
K
Y
L
-
Y
A
P
A
L
V
E
D
T
E
M
K
T
D
L
S
K
N
K
Y
I
S
E
V
L
E
E
G
K
T
V
D
M
A
I
V
G
V
S
S
P
Y
N
H
S
T
M
E
E
I
--
G
Y
-
I
N
S
E
D
I
E
E
L
R
Y
K
D
V
V
G
D
I
N
S
R
F
F
T
A
D
G
K
E
A
-
K
T
E
I
N
T
H
V
I
G
L
S
L
E
E
L
K
N
I
P
T
V
V
A
L
A
N
G
L
Q
K
K
E
A
L
V
A
A
L
N
A
G
L
I
D
V
I
V
I
T
D
R
M
A
E
Y
I
L
---------------
3
PsiBlast_PDB
76.94
29%
-106
- C4 -
3EFB
-
?
A:
[12-266]
-----------------------------------------------------------
E
N
L
-
W
-
L
E
Q
Q
L
K
Q
K
F
G
L
K
D
V
V
V
V
S
G
N
D
E
D
E
E
T
Q
L
A
M
M
G
L
H
-
G
A
Q
L
L
D
R
L
L
E
P
G
D
-
I
V
G
F
S
W
G
R
A
V
S
A
L
V
E
N
L
P
Q
-
A
G
-
Q
S
R
Q
-
L
I
C
V
P
I
I
G
G
-
P
S
G
K
-
L
-
E
S
R
Y
H
V
N
T
L
T
Y
S
A
-
A
A
K
L
K
G
E
S
H
L
A
-
D
F
P
A
L
L
D
N
P
L
I
R
N
G
I
M
Q
S
Q
H
F
K
T
I
S
A
Y
W
D
N
L
D
I
A
L
V
G
I
G
S
P
-----------
A
F
-
Y
G
G
E
E
S
D
D
L
N
A
R
Q
V
A
G
D
I
C
S
R
F
F
D
I
H
G
A
M
V
-
E
T
N
M
S
E
K
T
L
S
I
E
M
N
K
L
K
Q
A
R
Y
S
I
G
I
A
M
S
E
E
K
Y
S
G
I
I
G
A
L
R
G
K
Y
I
N
C
L
V
T
N
S
S
T
A
E
L
L
L
K
--------------
24
HHSearch
76.04
22%
-97
- C4 -
3NZE
-
?
A:
[7-263]
-----------------------------------------------------------
D
T
G
-
P
E
L
E
S
Q
I
R
N
Q
Y
G
V
-
D
V
H
V
V
P
V
L
D
T
L
N
E
A
E
T
L
D
R
V
A
M
Q
A
A
R
T
I
G
P
L
V
D
S
N
A
-
I
I
G
V
A
W
G
A
T
L
S
A
V
S
R
H
L
T
R
-
K
M
-
T
H
-
D
-
S
I
V
V
Q
L
N
G
A
-
G
N
-
M
-
Q
T
T
G
I
T
Y
A
S
D
I
M
R
R
F
-
G
S
A
Y
G
A
R
V
E
Q
F
-
P
V
P
A
F
F
D
H
A
S
T
K
T
A
M
W
N
E
R
S
V
Q
R
I
L
D
L
Q
A
R
M
S
I
A
I
F
G
V
G
S
V
D
---
H
V
Y
A
G
--
G
Y
-
L
D
E
H
D
L
T
M
L
A
A
D
D
V
V
G
D
V
A
T
V
F
F
R
S
D
G
S
S
D
-
G
I
T
L
N
E
R
S
T
G
P
S
H
E
Q
L
R
Q
V
R
R
R
I
C
V
V
S
G
A
S
K
I
N
G
L
Q
G
A
L
A
A
G
L
A
T
D
L
I
L
D
E
A
S
A
R
R
L
V
S
--------------
8
PsiBlast_PDB
75.16
27%
-91
- C4 -
4OQP
7
DEOR_BACSU
A:
[15-257]
-----------------------------------------------------------------
L
G
S
I
L
E
E
K
Y
G
L
L
E
A
H
V
V
F
S
-
P
T
P
D
Y
A
G
I
T
H
D
L
S
R
Y
G
A
E
Y
M
H
E
T
V
K
D
G
D
-
I
V
G
V
S
W
G
T
T
M
Y
Q
I
A
Q
N
M
Q
P
-
K
Q
-
V
K
-
G
-
V
E
V
V
Q
L
K
G
G
-
I
S
-
H
-
S
-
R
V
N
T
Y
S
A
E
T
I
Q
L
F
-
A
E
A
F
Q
T
M
P
R
Y
L
-
P
L
P
V
V
F
D
N
A
D
V
K
R
M
V
E
K
D
R
H
I
E
R
I
I
E
M
G
K
Q
A
N
I
A
L
F
T
V
G
T
V
R
D
E
A
L
L
F
R
L
--
G
Y
-
F
N
E
E
E
-
K
A
L
L
K
K
Q
A
V
G
D
I
C
S
R
F
F
D
A
K
G
N
I
C
-
S
S
A
I
N
D
R
T
I
G
V
E
L
Q
D
L
R
L
K
E
R
S
I
L
V
A
G
G
S
R
K
V
S
S
I
H
G
A
L
T
G
K
Y
A
N
V
L
I
I
D
Q
H
T
A
R
A
L
V
N
--------------
9
PsiBlast_PDB
74.78
27%
-92
- C4 -
4OQQ
1
DEOR_BACSU
A:
[15-257]
-----------------------------------------------------------------
L
G
S
I
L
E
E
K
Y
G
L
L
E
A
H
V
V
F
S
-
P
T
P
D
Y
A
G
I
T
H
D
L
S
R
Y
G
A
E
Y
M
H
E
T
V
K
D
G
D
-
I
V
G
V
S
W
G
T
T
M
Y
Q
I
A
Q
N
M
Q
P
-
K
Q
-
V
K
-
G
-
V
E
V
V
Q
L
K
G
G
-
I
S
-
H
-
S
-
R
V
N
T
Y
S
A
E
T
I
Q
L
F
-
A
E
A
F
Q
T
M
P
R
Y
L
-
P
L
P
V
V
F
D
N
A
D
V
K
R
M
V
E
K
D
R
H
I
E
R
I
I
E
M
G
K
Q
A
N
I
A
L
F
T
V
G
T
V
R
D
E
A
L
L
F
R
L
--
G
Y
-
F
N
E
E
E
-
K
A
L
L
K
K
Q
A
V
G
D
I
C
S
R
F
F
D
A
K
G
N
I
C
-
S
S
A
I
N
D
R
T
I
G
V
E
L
Q
D
L
R
L
K
E
R
S
I
L
V
A
G
G
S
R
K
V
S
S
I
H
G
A
L
T
G
K
Y
A
N
V
L
I
I
D
Q
H
T
A
R
A
L
V
N
D
-------------